Clinical and Experimental Dental Research最新文献

{"title":"Efficacy of Fluoride Toothpaste Fortified With Micro- and Nano-Hydroxyapatite on Remineralization and Surface Roughness of Synthetic Enamel","authors":"Porawit Kamnoedboon,&nbsp;Phakvalunch Rujiraprasert,&nbsp;Thawanrat Singthong,&nbsp;Thanaphum Osathanon,&nbsp;Chalermkwan Makornpan,&nbsp;Chawalid Pianmee,&nbsp;Naruporn Monmaturapoj,&nbsp;Dusit Nantanapiboon","doi":"10.1002/cre2.70471","DOIUrl":"10.1002/cre2.70471","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the remineralization efficacy and surface effects of 1450 ppm fluoride toothpaste fortified with synthetic hydroxyapatite (Syn-HAP) of varying particle sizes and concentrations on synthetic enamel.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Nano-sized Syn-HAP (nanoSyn-HAP) was synthesized via a mechanochemical process and characterized using X-ray diffraction (XRD) and transmission electron microscopy (TEM). Sixty disc-shaped synthetic pellets underwent artificial caries induction and were randomly divided into five groups: Untreated (negative control), commercial 1450 ppm fluoride toothpaste (FT), FT plus 5% micrometer-sized Syn-HAP (FT+5mHAP), FT plus 5% nanoSyn-HAP (FT+5nHAP), and FT plus 10% nanoSyn-HAP (FT+10nHAP). Specimens then underwent a 15-day pH cycling regimen with twice-daily treatments. Knoop microhardness was evaluated at baseline, post-caries induction, and post-treatment; surface roughness and scanning electron microscopy (SEM) were assessed at baseline and post-treatment. Data were analyzed using ANOVA and Bonferroni post-hoc tests (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>XRD confirmed a pure hydroxyapatite phase, and TEM indicated that 93% of particles were smaller than 50 nm. All toothpaste-treated groups exhibited significant microhardness recovery versus the untreated group (<i>p</i> &lt; 0.05), with no significant differences among them. The untreated and FT groups showed significantly increased roughness after 15 days (<i>p</i> &lt; 0.01), whereas all Syn-HAP groups maintained smoothness comparable to baseline, with significantly lower roughness than FT (<i>p</i> &lt; 0.01). SEM corroborated these findings, revealing smoother surfaces with particle integration in the Syn-HAP groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Under the conditions of this in vitro study, supplementing 1450 ppm fluoride toothpaste with Syn-HAP produced surface microhardness recovery that did not differ significantly from that of standard fluoride toothpaste, while significantly improving the preservation of surface smoothness. Syn-HAP-fortified formulations therefore offer a promising approach for caries management, combining effective surface hardening with superior surface integrity, although confirmation in in situ and in vivo settings is required.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An In Vitro and In Vivo Assessment of Acidogenicity of Several Alcoholic and Non-Alcoholic Beverages","authors":"Riccardo Guazzo,&nbsp;Eriberto Bressan,&nbsp;Anna Lehrkinder,&nbsp;Guglielmo Campus,&nbsp;Edoardo Stellini,&nbsp;Cristiano Tomasi,&nbsp;Peter Lingström","doi":"10.1002/cre2.70462","DOIUrl":"10.1002/cre2.70462","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study evaluated the acidogenic potential of selected alcoholic and non-alcoholic beverages using complementary in vitro (initial pH and titratable acidity) and in vivo (tooth-surface pH after exposure) methods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Two sparkling wines (traditional and tank method), red wine, white wine, an alcoholic soft drink, a non-alcoholic soft drink, pilsner beer, and orange juice were examined. In vitro, initial pH and titratable acidity were measured at room temperature (22°C). In vivo, 19 healthy adults held 10 mL of each selected beverage intraorally for 1 min, after which tooth-surface pH was recorded at predefined time points for up to 30 min using a microelectrode. Data were analyzed using ANOVA with post-hoc Tukey tests (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In vitro, the non-alcoholic soft drink had the lowest initial pH and beer the highest. Orange juice and sparkling wine produced by the traditional method showed the greatest titratable acidity. All beverages except water caused an immediate in vivo pH decrease, followed by recovery toward baseline within 10–15 min. The lowest mean tooth-surface pH was 6.2 for the traditional-method sparkling wine.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Alcoholic and non-alcoholic beverages differed substantially in their acidogenic properties. Salivary buffering promoted rapid pH recovery, but beverages with high titratable acidity, particularly traditional-method sparkling wine and orange juice, produced a more sustained acid challenge. Because this study measured short-term pH responses rather than dental hard-tissue loss, the findings should be interpreted as indicators of acidogenicity rather than direct measures of erosive damage.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13635684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Temporomandibular Disorder-Related Symptoms, Psychological Distress, and Sleep Quality Among Hospital Healthcare Staff.","authors":"Xiang Bian, Guoqiang Yan","doi":"10.1002/cre2.70428","DOIUrl":"10.1002/cre2.70428","url":null,"abstract":"<p><strong>Objectives: </strong>To examine associations between temporomandibular disorder (TMD)-related symptoms, psychological distress, and sleep quality among hospital healthcare staff, and to explore whether cumulative psychological-sleep burden was associated with pain-related TMD in a graded pattern.</p><p><strong>Materials and methods: </strong>This cross-sectional study included 193 healthcare employees from a tertiary public hospital in Beijing, China. TMD-related symptoms were assessed using self-reported symptom items from the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) Symptom Questionnaire for symptom screening rather than definitive clinical diagnosis. Psychological distress was measured using the Depression Anxiety Stress Scales-21 (DASS-21), and sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). An exploratory psychological-sleep composite burden index was constructed by summing standardized depression, anxiety, stress, and global PSQI scores. Multivariable logistic regression models evaluated associations between the composite index and pain-related TMD, adjusting for age group, sex, and occupational role. Quartile-based trend and sensitivity analyses were performed.</p><p><strong>Results: </strong>Pain-related TMD was reported by 67 participants (34.7%). Each 1-SD increase in the composite index showed a positive but borderline association with pain-related TMD (adjusted OR = 1.36, 95% CI: 1.00-1.86, p = 0.052). In quartile-based analysis, each higher burden quartile was associated with increased odds of pain-related TMD (adjusted OR = 1.37, 95% CI: 1.03-1.81, p = 0.030). After excluding headache-only cases, the quartile-based association remained significant (adjusted OR = 1.37, 95% CI: 1.02-1.85, p = 0.037). Symptom-specific analyses showed heterogeneous patterns.</p><p><strong>Conclusions: </strong>Higher cumulative psychological-sleep burden was associated with greater odds of pain-related TMD among hospital healthcare staff, particularly in quartile-based analyses. These findings support a cautious biopsychosocial interpretation and suggest that psychological distress and sleep quality may be relevant considerations in occupational oral health assessment.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":"e70428"},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, Risk Indicators, and Patient-Reported Outcomes of Labial Gingival Recession Following Orthodontic Treatment: A Retrospective Study.","authors":"Sarah Benabdallah, Parham Hazrati, Catherine Delcourt, Pierre-Alexandre Chataigner, Nassima Ramdane, Claire Averlant-Dubois, Hom-Lay Wang, Kevimy Agossa","doi":"10.1002/cre2.70483","DOIUrl":"https://doi.org/10.1002/cre2.70483","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the prevalence, distribution, and risk indicators of gingival recession (GR) following orthodontic treatment (OT) in both private and hospital-based settings, and to evaluate its impact on patient satisfaction and willingness to seek corrective treatment.</p><p><strong>Materials and methods: </strong>Clinical and radiographic records from baseline to follow-up were retrospectively analyzed. Additionally, participants completed a survey on satisfaction, perception of GR if present, and willingness to seek corrective treatment. Incident and persistent GR were analyzed separately. Bayesian mixed-effects logistic regression with weakly informative priors was used to identify risk indicators for incident GR.</p><p><strong>Results: </strong>A total of 103 patients (2030 teeth; mean age: 20.7 ± 9.7 years) were included. GR prevalence increased from 1.7% at baseline to 2.0% at appliance removal and continued to rise during the retention phase (3%-5%), with a site-specific distribution. Among 1996 teeth free of GR at baseline, 49 developed incident GR. A thin-scalloped gingival phenotype was the strongest risk indicator for incident GR (OR = 4.10; 95% CrI: 1.25-13.46). Most baseline GR persisted throughout follow-up. Satisfaction with OT remained high (mean score: 8.99 ± 1.04 on a 10-point scale) and was not significantly influenced by GR or treatment setting.</p><p><strong>Conclusions: </strong>Gingival recession occurrence after orthodontic treatment is time- and site-dependent. A thin-scalloped gingival phenotype is the main risk indicator for incident GR, whereas pre-existing recession is highly persistent. Despite its occurrence, gingival recession had limited impact on patient satisfaction.</p><p><strong>Clinical relevance: </strong>This study provides long-term, multicenter data on gingival recession following orthodontic treatment, and is the first to assess its impact on patient perception. The findings may help inform risk-based treatment planning and individualized patient counseling in orthodontic care.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":"e70483"},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Macro and Zoom Lenses for Dental Shade Selection: An In Vitro Study.","authors":"Ahmed Ali Jasim, Huda Ahmed Abdullah, Amer Abbas Mohammed, Samah Fadhil Al-Qazzaz, Mafaz Mahdi Mohsin","doi":"10.1002/cre2.70484","DOIUrl":"https://doi.org/10.1002/cre2.70484","url":null,"abstract":"<p><strong>Objective: </strong>This in vitro study evaluated the color accuracy and image sharpness of common macro and zoom lenses on a full-frame body and tested whether differences among macro-lens brands are clinically meaningful.</p><p><strong>Materials and methods: </strong>26 VITA 3D-Master shade tabs were each photographed three times under standardized, cross-polarized conditions on a Nikon D610. Three macro lenses (Nikon 105 mm, Sigma 105 mm, and Tamron 90 mm) and four zoom lenses (Nikon 24-70 mm, Nikon 24-120 mm, Sigma 24-70 mm, and Nikon 24-85 mm) were compared. RAW files were converted to CIELAB; reference L*a*b* values were obtained with a 45°/0° spectroradiometer under D65. Color difference (ΔEab, CIE76) was computed for every image. Sharpness was assessed by ISO 12233 slanted-edge SFR (MTF50) at f/16 and f/22. Linear mixed-effects models with shade tab as a random effect were fitted; equivalence was tested with two one-sided tests (TOST) at a prespecified ΔEab margin of 0.6.</p><p><strong>Results: </strong>All macro lenses produced low, clinically acceptable color errors (mean ΔEab = 1.2; SD = 0.2) with negligible inter-brand differences, and all macro-macro comparisons met the 0.6 equivalence margin. Zoom lenses showed significantly higher errors (mean = 2.95-3.35; SD = 0.42-0.50) and failed equivalence. Brand differences among macro lenses were non-significant (F = 0.92, p = 0.40), whereas macro-vs-zoom differences were highly significant (F = 792.1, p < 0.0001); 81% of pooled zoom images exceeded the ΔEab acceptability threshold of 2.7, versus none of the macro images. MTF50 confirmed superior macro sharpness, with macro-macro differences within ±5% of the Nyquist frequency.</p><p><strong>Conclusions: </strong>Dedicated macro lenses are required for accurate shade photography, with general-purpose zoom lenses producing clinically unacceptable color errors.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":"e70484"},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a New Bioadhesive Gel in the Prevention of Bacterial Biofilms on Dental Implants: An In Vitro Study.","authors":"María Baus-Domínguez, Paula Hermida-Cabrera, Javier Pascual, Fernando Vivancos-Cuadras, María-Ángeles Serrera-Figallo, José-Luis Gutiérrez-Pérez, Daniel Torres-Lagares","doi":"10.1002/cre2.70422","DOIUrl":"10.1002/cre2.70422","url":null,"abstract":"<p><strong>Objectives: </strong>Peri-implantitis is a reality that clinicians face in their daily practice. Current evidence discusses the applicability of bacteriostatic or bactericidal methods in order to minimize the colonization of bacteria, which entails controversy. In this scenario there arises a need to develop surfaces that minimize bacteria's appetite for them.</p><p><strong>Methods: </strong>An in vitro microbiological study was conducted to assess the effect of a chlorhexidine-based bioadhesive gel on the growth and adhesion of a simplified peri-implantitis-associated microbial consortium. Grade IV titanium disks with three surface types (machined, sandblasted, and ContacTi) were incubated with the consortium under anaerobic conditions for 10 days, with and without gel treatment. Microbial viability was evaluated by colony-forming unit (CFU) counts, and biofilm structure was analyzed by scanning electron microscopy. Microbial community composition was assessed using 16S rRNA gene amplicon sequencing.</p><p><strong>Results: </strong>After 10 days, gel-treated implants showed complete inhibition of cultivable microorganisms, with CFU values reduced below the detection limit on all surfaces, compared with untreated implants (p < 0.05). In untreated samples, ContacTi surfaces exhibited higher bacterial viability than machined and sandblasted surfaces. Metataxonomic analysis revealed a marked reduction in peri-implant pathogens, particularly Porphyromonas gingivalis, whose relative abundance decreased from approximately 20% in the initial inoculum to ~1% after incubation.</p><p><strong>Conclusions: </strong>The bioadhesive gel demonstrated a quantitatively significant antimicrobial effect, preventing biofilm formation on all tested implant surfaces after 10 days.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":"e70422"},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Chlorhexidine, Essential Oil-Based, and Stannous Fluoride Mouthrinses on the Color Stability and Surface Roughness of CAD/CAM Ceramics.","authors":"Fateme Ghasemian Gorji, Fariba Ezoji, Ghazaleh Ahmadizenouz, Seyedali Seyedmajidi","doi":"10.1002/cre2.70469","DOIUrl":"10.1002/cre2.70469","url":null,"abstract":"<p><strong>Objectives: </strong>The long-term esthetic performance of CAD/CAM ceramic restorations may be influenced by repeated exposure to therapeutic mouthrinses. This study evaluated the effects of chlorhexidine, essential oil-based, and stannous fluoride mouthrinses on the color stability (ΔE) and surface roughness (R_a) of glazed and polished CAD/CAM ceramics.</p><p><strong>Materials and methods: </strong>In this in vitro experimental study, 320 specimens fabricated from four CAD/CAM ceramic materials (Vita Mark II, IPS e.max CAD, CAD, Celtra Duo, and high-translucency zirconia) were randomly assigned to glazed or polished surface treatment groups and immersed daily for 20 min in chlorhexidine, essential oil-based, stannous fluoride mouthrinses, or distilled water (control) for 30 days. Color stability was assessed using spectrophotometry based on the CIE Lab* color system, and surface roughness was measured using laser profilometry. Data were analyzed using one-way ANOVA followed by Tukey's post hoc test (α = 0.05).</p><p><strong>Results: </strong>The effects of therapeutic mouthrinses on color stability and surface roughness varied according to ceramic material and surface finish. The greatest color change was observed in polished IPS e.max CAD immersed in the essential oil-based mouthrinse (ΔE = 3.69), whereas the lowest ΔE was recorded for glazed Celtra Duo immersed in stannous fluoride (ΔE = 1.59). Polished specimens consistently exhibited greater increases in surface roughness than glazed specimens across all ceramic materials. Significant differences in ΔE and/or R_a were identified according to ceramic type, mouthrinse composition, and surface finish (p < 0.05).</p><p><strong>Conclusion: </strong>The effects of therapeutic mouthrinses on CAD/CAM ceramics depend on both ceramic composition and surface finish. Essential oil-based mouthrinse produced the greatest color changes in several ceramic materials, whereas glazed surfaces generally demonstrated greater resistance to surface roughness changes than polished surfaces. These findings highlight the importance of considering both material selection and surface finishing when recommending therapeutic mouthrinse use for patients with CAD/CAM ceramic restorations.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":"e70469"},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Florid Cemento-Osseous Dysplasia and Simple Bone Cyst Association: Co-Occurrence or Evolution of the Disease? Two Case Reports and Literature Review.","authors":"Victor Voisin, Paul Galvez, Jean-Christophe Fricain, Mathilde Fénelon","doi":"10.1002/cre2.70459","DOIUrl":"10.1002/cre2.70459","url":null,"abstract":"<p><strong>Objectives: </strong>Cemento-osseous dysplasia (COD) is the most common benign fibro-osseous lesion of the jaws, typically asymptomatic and identified through characteristic radiographic features. However, its rare association with simple bone cysts (SBCs) can significantly alter its presentation, mimicking more aggressive jaw lesions. This study aims to report additional cases of COD-associated SBCs and to review the literature to evaluate whether such lesions may represent a specific manifestation of the COD spectrum.</p><p><strong>Materials and methods: </strong>Two cases of florid COD with atypical radiolucencies were described, both exhibiting cortical thinning and focal perforation, as well as bone expansion.</p><p><strong>Results: </strong>Surgical exploration was performed to rule out a more serious aggressive odontogenic pathology and revealed empty bone cavities, consistent with SBCs.</p><p><strong>Conclusions: </strong>These cases support the concept of secondary SBCs as part of the COD spectrum. A review of the literature highlights differences in age, sex, location, clinical and radiological features, as well as healing patterns compared to solitary SBCs.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":"e70459"},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison Between Skeletally-Anchored and Conventional Maxillary Protraction in Growing Class ΙΙΙ Patients: A Systematic Review and Meta-Analysis","authors":"Christianna Iris Papadopoulou,&nbsp;Nusha Paschaei,&nbsp;Giulia Brunello,&nbsp;Rebecca Jungbauer,&nbsp;Kathrin Becker","doi":"10.1002/cre2.70466","DOIUrl":"10.1002/cre2.70466","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of this systematic review was to evaluate the skeletal and dental effects of skeletally-anchored (SA) maxillary protraction compared with conventional facemask (FM) therapy in growing patients with Class III malocclusion, while controlling for the confounding effect of rapid maxillary expansion (RME).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A systematic literature search (MEDLINE, Cochrane Library, Virtual Health Library, Web of Science, Google Scholar), which involved two screening stages, was performed until January 2026 and identified prospective clinical trials comparing SA with conventional tooth-borne FM therapy. Only studies in which expansion protocols were applied uniformly across groups were included. Risk of bias was assessed with RoB 2 and ROBINS-I tools, and random effects meta-analyses were conducted for cephalometric outcomes. The certainty of the evidence was evaluated according to the grading of recommendations, assessment, development, and evaluation (GRADE) approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Five prospective trials (3 RCTs, 2 CCTs; <i>n</i> = 194 participants) met the inclusion criteria. Random-effects meta-analyses showed a modest but significant greater increase in SNA for SA (MD 0.65°; 95% CI 0.18–1.13, <i>I</i>² = 0.0%) and consistently fewer dental side effects with SA: upper-molar mesialization (−1.14 mm; −2.12 to −0.17, <i>I</i>² = 10.3%), molar extrusion (−0.74 mm; −1.07 to −0.40, <i>I</i>² = 0.0%), and maxillary incisor proclination (−2.47°; −4.14 to −0.80, <i>I</i>² = 0.0%). The mandibular plane rotation did not differ significantly (−0.38°; −1.67 to 0.91, <i>I</i>² = 45.6%). Risk of bias was assessed as “some concerns” in RCTs and “serious” in non-randomized studies. The certainty of evidence ranged from very low to moderate according to GRADE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Within the limitations of the available short-term evidence, and given the low-to-moderate certainty of the pooled estimates, SA was associated with fewer dental side effects and a statistically significant, though not clinically relevant, gain in skeletal efficacy. Future long-term, age-stratified randomized trials are needed to confirm the long-term stability of these findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Root Canal Dressings on Extraradicular pH in a Sealed Apex Model: An In Vitro Study","authors":"Alina Paganini,&nbsp;Eva Magni,&nbsp;Wadim Leontiev,&nbsp;Thomas Connert,&nbsp;Anne Géraldine Guex,&nbsp;Andreas Filippi","doi":"10.1002/cre2.70467","DOIUrl":"10.1002/cre2.70467","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Endodontic treatment is mandatory after severe dental trauma such as avulsion or intrusion. Initial intracanal dressing with calcium hydroxide should be avoided according to international guidelines due to potential periodontal ligament damage by pH elevation. However, whether an intracanal dressing is able to alter the extraradicular site remains unclear. This in vitro study quantified extraradicular pH changes through dentinal diffusion of calcium hydroxide or Ledermix in a sealed-apex model in human teeth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Thirty-five cryopreserved human premolars were prepared with or without cemental defects and received UltraCal XS, Ledermix, or saliva as an intracanal dressing. In the test groups, apices were sealed with composite resin material; the positive control remained with open apices. Teeth were stored in NaCl solution. External pH of the solution was measured on days 1, 3, 5, 7, and 14. A mixed model was applied to determine the effect of group, apical plug, cemental defect, and time on pH alterations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Calcium hydroxide in teeth without apical sealing caused a sustained external alkalinisation (± pH 12). In teeth with apical sealing, no significant external rise in pH occurred for any dressing over time compared to day 1; only one sealed specimen with calcium hydroxide dressing reached pH 9.1 transiently. The pH in Ledermix and saliva groups remained roughly neutral irrespective of sealing or cemental defects. Mixed-effects modeling identified the apical plug as the only significant factor (<i>p</i> &lt; 0.05); presence of cemental defects or days after treatment had no significant effect on pH.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In a sealed-apex model, intracanal dressings did not raise the external pH significantly by dentinal diffusion. Therefore, the results do not support the advantage of a certain intracanal dressing in endodontic treatment after severe dislocation injuries of teeth without open apices with respect to maintained physiological pH.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}