Clinical and Experimental Dental Research最新文献

{"title":"An Emulation Model Combining Caries and Periodontitis Risk Assessment With Student Performance Report: An Exploratory Project","authors":"David Johnsen,&nbsp;Aditi Jain,&nbsp;Carlos Garaicoa-Pazmino,&nbsp;Justine Kolker,&nbsp;Megumi Williamson,&nbsp;Wei Shi","doi":"10.1002/cre2.70135","DOIUrl":"https://doi.org/10.1002/cre2.70135","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Patient risk assessments for caries and periodontitis are hourly activities for dentists. The present study tested a caries and periodontitis risk assessment format based on managing the person using a critical thinking emulation model including levels of patient capacity and disease management. Additionally, we explored factors in student analysis contributing to the designation of higher/lower-risk determinants for caries and periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Third-year dental students assessed patient risk for recurring disease in periodontics and cariology exercises. The risk assessment thought process becomes the learning outcome, learning guide, and assessment instrument. Students demonstrated the risk assessment analysis with a patient using PowerPoint presentations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Students applied over 95% of procedural steps (e.g., exam, history) with a range of judgmental steps (65%–100%) in risk level, interprofessional practice, disease progression, compliance, among others. Designation of higher and lower-risk determinants for periodontitis risk assessment (<i>n</i> = 38), students identified differences in patient risk based on whether the patient had diabetes or smoked (<i>p</i> = 0.013 to &lt; 0.001). For caries risk assessment (<i>n</i> = 40), students identified differences between lower- and higher-risk patients for patient compliance (<i>p</i> = 0.001), behavior control (<i>p</i> = 0.006), diet control (<i>p</i> &lt; 0.001), and prognosis (<i>p</i> = 0.005).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The combined learning guide warrants further exploration in guiding dental students' risk analysis for periodontitis and caries by emulating the thinking process of a master clinician. Future work includes probing analysis with binary conclusions, interventions for high-risk people with recurring disease, and the association of treatment and health.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Methods Used to Detect Cracked Teeth","authors":"Veronica Kindaro,&nbsp;Huon Molland,&nbsp;Sara Shirbegi,&nbsp;Paul Renner,&nbsp;Unni Krishnan","doi":"10.1002/cre2.70138","DOIUrl":"https://doi.org/10.1002/cre2.70138","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Cracked tooth diagnosis is challenging due to the unknown diagnostic accuracy of tools, resulting in misdiagnosis and suboptimal treatment outcomes. The primary objective of this study was to determine the diagnostic accuracy of four commonly used visual tests in diagnosing cracked teeth based on clinical appearance, independent of patient symptoms. The secondary objective was to assess if clinical experience influences the ability to accurately identify the presence of a crack. The tertiary objective was to assess the ability of the index tests to accurately determine the location of the crack.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>The test sample included 30 teeth extracted due to a suspected crack. Index tests included macrophotography, surgical microscope, transillumination, and DIAGNOcam. Microcomputed tomography (micro-CT) served as the gold standard. Four examiners of varying experience assessed images of each tooth paired with each index test. The examiner's findings were compared against micro-CT to determine the diagnostic accuracy of index tests. The relationship between clinical experience and diagnostic accuracy was explored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Transillumination demonstrated the highest accuracy (65.3%) and sensitivity (68.8%) for diagnosing cracks. Macrophotography and high-magnification microscope had the highest specificity of 92.9%. Positive predictive value (PPV) was greatest with high-magnification microscope (96.7%). The low-magnification microscope demonstrated the lowest accuracy (52.2%). Intra-rater reliability was moderate to substantial, and inter-rater reliability was fair. Experienced dentists were more accurate in detecting cracked teeth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Visual diagnostic methods cannot definitively diagnose cracks. Further studies are required to explore the impact of a combination of tools in diagnosing cracked teeth.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological Evaluation of Subcutaneous Tissue Reactions to a Novel Bilayer Polycaprolactone/Silk Fibroin/Strontium Carbonate Nanofibrous Membrane for Guided Bone Regeneration: A Study in Rabbits","authors":"Lida Kheiri,&nbsp;Arash Golestaneh,&nbsp;Mehdi Mehdikhani,&nbsp;Sayed Mohammad Razavi,&nbsp;Niloofar Etemadi","doi":"10.1002/cre2.70140","DOIUrl":"https://doi.org/10.1002/cre2.70140","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The selection of appropriate biomaterial for guided bone regeneration is challenging. The blending of polymers is a simple method to retain their characteristics and to compensate for the drawbacks of each component. The release of Sr⁺² (strontium) ions from the polycaprolactone/strontium carbonate (PCL/SrC) nanocomposite is the main reason of enhanced osteogenesis. The most important reasons of clinical failure after using biomaterials include infections and lack of tissue-integration. Modifications of silk fibroin (SF)–based membranes improved new bone formation in animal studies without inflammatory reaction. The aim of the present study was to compare biological response of the subcutaneous connective tissue to a novel bilayer PCL (60 wt%)/SF (20 wt%)/SrC (20 wt%) membrane to a commercially available collagenous membrane.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Eighteen male New Zealand rabbits were randomly divided into three groups, and all received subcutaneously the following materials: novel bilayer membrane, commercial membrane, and empty defect as control group, which were tested after 7, 14, and 28 days. The type and severity of inflammation, granulation tissue, and fibrous tissue were assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The connective tissue surrounding the implanted samples of each group exhibited the presence of similar cells close to the control groups. Statistical analyses showed no significant differences between the specimens in each time period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In general, the novel bilayer nanocomposite membrane was a biocompatible material and produces a similar subcutaneous response compared to commercially available membrane. Besides, it demonstrated promise for guided bone regeneration technique for treating the osseous defects of oral and maxillofacial region.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-Dependent Changes in Effects of Butyrate on Human Gingival Fibroblasts","authors":"Haruki Otani,&nbsp;Jumpei Washio,&nbsp;Aoi Kunitomi,&nbsp;Satoko Sato,&nbsp;Yuki Abiko,&nbsp;Shiori Sasaki,&nbsp;Kazumasa Ohashi,&nbsp;Satoru Yamada,&nbsp;Nobuhiro Takahashi","doi":"10.1002/cre2.70120","DOIUrl":"https://doi.org/10.1002/cre2.70120","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Butyrate is one of major metabolites of periodontitis-associated bacteria and often detected in periodontal pockets. Butyrate has been considered to affect human gingival fibroblasts (HGFs); however, there was no information on its long-term effect as occurs in periodontitis. Therefore, this study aimed to evaluate the time-dependent effects of butyrate on HGFs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>The effects of butyrate on HGF proliferation, apoptosis, cell morphology, glucose metabolic activity, butyrate metabolic activity, and cell migration ability were evaluated by cell counting, DNA electrophoresis, cell staining, pH-stat system, HPLC, and scratch test, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>HGF proliferation was temporarily inhibited by 5–10 mM butyrate (<i>p</i> &lt; 0.05); however, it resumed at 24 h with morphological changes from spindle to slightly widened (<i>p</i> &lt; 0.05). HGFs cultured with 10 mM butyrate for 12–24 h shifted the glucose metabolic pathway from oxidative phosphorylation to glycolysis (<i>p</i> &lt; 0.05), and increased butyrate consumption, which returned to control levels over 24 h. HGF migration ability tended to decrease at 72 h.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>HGF cell proliferation and glucose/butyrate metabolism were temporarily inhibited by butyrate and then recovered in a time-dependent manner, accompanied by changes in cell morphology. These time-dependent effects may help to understand the role of butyrate in the pathology of periodontitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Color Stability and Surface Roughness of Interim Crowns Fabricated by Conventional, Milling and 3D Printing Methods","authors":"Zahra Hashemzade,&nbsp;Mohammad Alihemmati,&nbsp;Seyed Mohammad Reza Hakimaneh,&nbsp;Sayed Shojaedin Shayegh,&nbsp;Mohammad Amin Bafandeh,&nbsp;Zahra Mohammadi","doi":"10.1002/cre2.70119","DOIUrl":"https://doi.org/10.1002/cre2.70119","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Manufacturing temporary restorations is part of the treatment process in fixed prostheses, which is accomplished by different methods. The aim of this study is to compare the color stability and surface roughness of provisional crowns made by 3D printing, conventional and milling methods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this semi-experimental study, 60 provisional crowns were created by conventional, milling, and 3D printing methods (20 samples for each method). Half of the samples in each group were treated with BisCover surface sealant after construction. The surface roughness was checked using a laser profilometer. To determine the color stability, an evaluation was done using a spectrophotometer on the first day and the second and fourth weeks after exposure to the tea solution, and ∆<i>E</i> was calculated using L*a*b* values. Statistical analysis was performed at a significance level of 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The surface roughness in the conventional group was significantly higher than in the milling group (<i>p</i> &lt; 0.05). The surface-treated samples had less surface roughness and more color stability than other samples (<i>p</i> &lt; 0.05). ∆E in the 3D printing group was higher than other groups in all time intervals (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The milling method can be considered the best method of making provisional crowns in terms of color stability and surface smoothness. Also, the use of sealing materials can have a significant effect on improving color stability and surface smoothness in provisional crowns made by any method.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Translucency in Different Thicknesses of Monolithic Zirconia Crowns","authors":"Azita Mazaheri,&nbsp;Ezatollah Jalalian,&nbsp;Arash Zarbakhsh,&nbsp;Mahshad Mazidabadi Farahani,&nbsp;Maryam Sayyari","doi":"10.1002/cre2.70132","DOIUrl":"https://doi.org/10.1002/cre2.70132","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Achieving optimal esthetics in dental restorations remains challenging, particularly with zirconia crowns, which, despite their durability, often exhibit less translucency than natural teeth. This study aimed to evaluate how varying thicknesses of monolithic zirconia crowns affect their translucency.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this experimental laboratory study, an initial model (a brass die) was scanned, and two dies, one black (9005 RAL), and one white (9010 RAL), were created from Resin according to the scanned file. Next, 30 zirconia crowns (ZrO₂, Arum, High Translucent) were fabricated in three thicknesses: 0.5, 0.8, and 1.5 mm. The color and translucency of the samples were assessed under standard lighting conditions (D65) using a spectroradiometer, and the color parameters <i>L</i>*, <i>b</i>*, and <i>a</i>* were recorded. The translucency of each sample was measured using the CIEDE2000 and CIE-Lab formulae. Data were analyzed using one-way ANOVA and the Tamhane test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Statistically significant changes in the color and translucency of the samples were observed with varying thicknesses (<i>p</i> &lt; 0.001). Specifically, the translucency parameter (TP), <i>L</i>*, and <i>b</i>* values decreased as the thickness increased, whereas <i>a</i>* values remained relatively stable. The average TP values for CIE-Lab ranged from 11.51 at 0.5 mm to 6.54 at 1.5 mm, and for CIEDE2000, they ranged from 8.19 at 0.5 mm to 4.82 at 1.5 mm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Within the limitations of this in vitro study, it can be concluded that reducing the thickness of monolithic zirconia restorations increases their translucency. Thinner zirconia restorations demonstrate a higher TP, which may offer improved esthetic integration in clinical applications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Casein Phosphopeptide Amorphous Calcium Phosphate and Proanthocyanidin on Bond Strength of Universal Adhesives to Caries-Affected Dentin in Primary Teeth: An In Vitro Study","authors":"Ali Nozari,&nbsp;Farnaz Haji Abbas Oghli,&nbsp;Fatemeh Parvizi,&nbsp;Zahra Jowkar,&nbsp;Maryam Pakniyat Jahromi,&nbsp;Seyed Ahmadreza Hamidi","doi":"10.1002/cre2.70131","DOIUrl":"https://doi.org/10.1002/cre2.70131","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to assess the impact of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and proanthocyanidin (PA) on the microshear bond strength (μSBS) of universal adhesives to caries-affected dentin (CAD) in primary teeth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>160 human primary second molars with occlusal caries were utilized, with CAD-exposed dentin surfaces. The teeth were categorized into four groups based on CAD pretreatment: no pretreatment, CPP-ACP for 3 min, PA for 1 min, and PA for 1 min followed by CPP-ACP for 3 min. Each group subdivided into four based on adhesive system (Gluma Bond Universal or All-Bond Universal) and application mode (etch and rinse; E&amp;R or self-etch; SE). Following composite resin restoration, μSBS measurements were taken after 24 h of water storage.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PA pretreatment showed the highest μSBS compared to controls and other methods (<i>p</i> &lt; 0.001). Conversely, CAD pretreatment with CPP-ACP + PA led to lower μSBS than the control (<i>p</i> = 0.009). Universal adhesive choice significantly influenced μSBS (<i>p</i> &lt; 0.001), with Gluma Bond Universal outperforming All-Bond Universal (<i>p</i> &lt; 0.001). The E&amp;R method demonstrated superior bond strength over SE (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>CAD pretreatment, particularly with PA, significantly impacted bond strength, with Gluma Bond Universal and the E&amp;R method proving optimal for enhancing μSBS to CAD. These findings offer valuable insights for refining adhesive protocols in pediatric dentistry, potentially improving clinical outcomes in restorative procedures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Increase in Masticatory Efficiency Between Removable Partial Dentures Retained With Clasps and Retained With Attachments","authors":"Linda J. Dula,&nbsp;Kujtim Sh. Shala,&nbsp;David Stubljar,&nbsp;Andrej Starc,&nbsp;Shera Kosumi","doi":"10.1002/cre2.70130","DOIUrl":"https://doi.org/10.1002/cre2.70130","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to evaluate and compare the masticatory efficiency of removable partial dentures (RPDs) retained with clasps versus those retained with attachments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A total of 107 patients fitted with 138 RPDs participated in the study; 87 RPDs (63.0%) were clasp-retained, and 51 RPDs (37.0%) were attachment-retained. Subjects chewed 5.0 g of peanuts for 30 s, and masticatory efficiency was measured using a spectrophotometer at an absorption rate of 590 µm. Measurements were taken before insertion, immediately after, and 1 and 3 months post-insertion of RPDs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The analysis revealed progressive masticatory efficiency improvements for both clasp-retained and attachment-retained RPDs over time, with significant enhancements observed at the 3-month post-insertion mark. Initially, clasp-retained RPDs showed slightly higher efficiency than attachment-retained RPDs; however, attachment-retained RPDs demonstrated superior efficiency after 3 months (<i>p</i> = 0.001). Consistent improvements were noted across different denture support types, with Triangular and Quadrangular supports showing the most notable gains by 3 months (<i>p</i> ≤ 0.006). GLMM analysis underscored the significant impact of time on masticatory efficiency (<i>F</i>(3, 511) = 4.926, <i>p</i> = 0.002), with no significant effects attributed to RPD type or support type alone, nor any significant interaction effects, indicating a universal improvement in masticatory function over time regardless of RPD design.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>RPD insertion significantly improves masticatory efficiency, particularly evident 3 months post-insertion, with attachment-retained RPDs outperforming clasp-retained types. Improvements in masticatory function over time are consistent across all RPD designs, unaffected by denture type or support structure. This emphasizes the role of denture design in both immediate adaptation and long-term treatment success, suggesting that time significantly contributes to enhanced masticatory efficiency regardless of RPD design, highlighting the importance of tailored prosthetic rehabilitation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analgesic Efficacy of Bromelain and Bromelain Plus Turmeric for Pain Control After Orthodontic Separator Placement: A Triple-Blind Randomized Clinical Trial","authors":"Shabnam Ajami,&nbsp;Seyyed Hadi Hosseini,&nbsp;Neda Babanouri,&nbsp;Zahra Hashemi","doi":"10.1002/cre2.70124","DOIUrl":"https://doi.org/10.1002/cre2.70124","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to compare the analgesic efficacy of Bromelain, Ibuprofen, and Bromelain plus turmeric for pain control after orthodontic separator placement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>This triple-blind randomized clinical trial included 135 patients over the age of 15 who required orthodontic treatment. The patients were randomly assigned to three groups: 400 mg Ibuprofen (Group A), 200 mg Bromelain (ANAHEAL; Group B), and 150 mg Bromelain + 300 mg Turmeric (ANAHEAL PLUS; Group C). The patients took one tablet immediately after the separator was placed. Four separators were placed at the mesial and distal regions of both maxillary first molars. The degree of pain and discomfort was measured using a visual analog scale (VAS) at the following time points: Immediately after the separator placement (T₀), 2 h posttreatment (T₁), 6 h posttreatment (T₂), 24 h posttreatment (T₃), and 48 h after separator placement (T₄). The data were analyzed using SPSS (version 15.0). Different statistical tests including ANOVA, Tukey's test, and paired <i>t</i>-test were utilized. <i>p</i> &lt; 0.05 was considered statistically significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Pain scores at 2 h (T1) and 6 h (T2) after separator placement differed significantly among the three groups (<i>p</i> = 0.006 and <i>p</i> = 0.025, respectively), with the Ibuprofen group experiencing significantly higher pain levels than the Bromelain and Bromelain Plus Turmeric groups. At 48 h (T4), a significant difference was observed only in chewing function (<i>p</i> = 0.024), where patients in the Bromelain group reported higher pain scores than those in the Ibuprofen group. Sex had no significant effect on pain perception (<i>P</i> &lt; <i>0.05</i>).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Bromelain with or without turmeric might be a useful alternative to Ibuprofen for pain control following orthodontic separator placement.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Osseodensification on Implant Stability and Marginal Bone Levels: A Randomized Control Clinical Trial","authors":"Ioanna Politi,&nbsp;Bahman Honari,&nbsp;Lewis Winning,&nbsp;Ioannis Polyzois","doi":"10.1002/cre2.70126","DOIUrl":"https://doi.org/10.1002/cre2.70126","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To compare the implant stability quotient values (ISQ) of implants placed using implant-specific drills (CD) and osseodensification drills (OD) at three different time points and to determine the effect of both drilling techniques on marginal bone levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>38 subjects were recruited and ISQ values and radiographic marginal bone levels were recorded after surgery (T1), and also at 3 (T2) and 4–5 months (T3). Clinical and radiographic marginal bone levels were also recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At T1, mean ISQ values ranged from 65.5 to 81 for the CD group and 29 to 80 for the OD group. For the CD group, ISQ values were 72.20 ± 2.6 (95% CI) at T1, 75.0 ± 2.0 at T2, and 74.8 ± 2.3 at T3. The corresponding ISQ values for the OD group were 68.1 ± 5.6, 71.9 ± 1.6, and 72.2 ± 2.4, respectively. Implants placed using CD drills showed greater stability at 3 months but not at placement or at 4–5 months. No statistically significant differences were identified regarding marginal bone levels between the two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>There was a notable increase in implant stability over time for both treatment modalities. At T2, implants inserted into osteotomies made with standard drills exhibited significantly greater stability compared to those placed using OD drills. However, the clinical relevance of this difference is questionable, as it was not observed at T3. Marginal bone levels were comparable for both groups over all time points.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: NCT05376020</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}