Bárbara Faria Sa de Barbosa, José Leôncio Ferreira Neto, Francisca Jennifer Duarte de Oliveira, Juliana Sales Osterno Leitão, Moan Jéfter Fernandes Costa, Pedro Henrique Sette-de-Souza, Pierre Basílio Almeida Fechine, Victor Pinheiro Feitosa, Boniek Castillo Dutra Borges
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引用次数: 0
摘要
目的通过对范围的回顾，对这些用于释放抗菌活性化合物的纳米结构粘土进行了详细的描述和表征。材料和方法系统的方法包括在PubMed/MEDLINE， Lilacs, Web of Science, Scopus， ScienceDirect和Embase数据库中进行搜索。两名独立和校准的研究人员（kappa: 0.94）根据PRISMA指南和乔安娜布里格斯研究所范围审查方法学小组（JBI）协议执行所有系统步骤。审稿人开发了一个数据提取表来收集关键信息。结果采用指定策略进行初始检索，共检索到文献782篇。在彻底审查稿件后，在排除重复和适用资格标准后，选出了五份。蒙脱土和高岭土纳米管是主要的纳米结构粘土。十六烷基吡啶氯是最常见的活性剂，其抗菌性能显著。树脂基复合材料是预防龋齿复发最常用的直接修复材料。结论虽然文献中发表的初步研究数量有限，但蒙脱土和高岭土纳米管是一种很有前景的纳米载体，可用于直接修复牙体材料中抗菌活性化合物的制备。
Nanostructured Clays Used as Carriers for Controlled Delivery of Antibacterial Compounds From Direct Restorative Dental Materials: A Scoping Review
Objective
Through a scoping review, this study meticulously mapped and characterized these nanostructured clays used to release antibacterial active compounds from direct restorative dental materials.
Material and Methods
The systematic approach involved searches in the PubMed/MEDLINE, Lilacs, Web of Science, Scopus, ScienceDirect, and Embase databases. Two independent and calibrated researchers (kappa: 0.94) performed all systematic steps according to the PRISMA guideline and the Joanna Briggs Institute Scoping Review Methodology Group (JBI) protocol. The reviewers developed a data extraction table to gather key information.
Results
A total of 782 articles were retrieved in the initial search using the specified strategies. After thoroughly reviewing the manuscripts, five were selected following the exclusion of duplicates and application of eligibility criteria. Montmorillonite and halloysite nanotubes emerged as the predominant nanostructured clay. Cetylpyridinium chloride was the most common active agent, notable for its antibacterial properties. Resin-based composites were the most frequently studied direct restorative material for the prevention of recurrent caries.
Conclusion
Although the number of primary studies published in the literature was limited, montmorillonite and halloysite nanotubes appear to be promising nanocarriers for antibacterial active compounds in direct restorative dental materials.
期刊介绍：
Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.
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