Abdolreza Jamilian, Helen Jamloo, Kurosh Majidi, Meysam Zarezadeh
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Heterogeneity was evaluated using the <i>I</i>² statistic and Cochrane's Q-test, with subgroup and sensitivity analyses conducted to identify sources of heterogeneity.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Eleven meta-analyses comprising 50 data sets were included. The results indicated that mini-screws significantly increased intermolar width (ES: 2.61 mm, 95% CI: 0.29–4.92, <i>p</i> = 0.02) and skeletal width (ES: 3.33 mm, 95% CI: 1.37–5.29, <i>p</i> = 0.001). However, no significant impact was found on interpremolar width or alveolar width before and after MARPE. Micro-implants significantly reduced molar movement (ES: −1.13 mm, 95% CI: −1.99 to −0.26, <i>p</i> = 0.01). Substantial heterogeneity was noted across several outcomes (<i>I</i>² > 50%), which persisted despite subgroup analyses.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Mini-screws and micro-implants enhance skeletal and intermolar width and control molar movement in orthodontic treatment. However, their effects on other outcomes are inconsistent, warranting further high-quality studies to strengthen clinical recommendations.</p>\n \n <p><b>Trial Registration:</b> PROSPERRO (CRD42023447137).</p>\n </section>\n </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70220","citationCount":"0","resultStr":"{\"title\":\"The Impact of Mini-Screws and Micro-Implants on Orthodontic Clinical Outcomes: An Umbrella Meta-Analysis\",\"authors\":\"Abdolreza Jamilian, Helen Jamloo, Kurosh Majidi, Meysam Zarezadeh\",\"doi\":\"10.1002/cre2.70220\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>This umbrella meta-analysis aimed to answer the clinical question: Do mini-screws and micro-implants improve specific orthodontic outcomes such as intermolar width, interpremolar width, suture expansion, molar movement, and skeletal width compared to conventional anchorage methods?</p>\\n </section>\\n \\n <section>\\n \\n <h3> Materials and Methods</h3>\\n \\n <p>A systematic search was performed in PubMed, Scopus, ISI Web of Science, and Google Scholar up to October 2024. 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引用次数: 0
摘要
本荟萃分析旨在回答临床问题：与传统固支方法相比，微型螺钉和微型种植体是否能改善特定的正畸结果，如磨牙间宽度、解释磨牙宽度、缝线扩张、磨牙运动和骨骼宽度？材料与方法系统检索PubMed、Scopus、ISI Web of Science和谷歌Scholar，检索截止至2024年10月。系统回顾和荟萃分析了微型螺钉和微型种植体在正畸治疗中的应用。使用AMSTAR 2评估方法学质量，并使用随机效应模型计算效应大小（ESs）和95%置信区间（ci）。采用I²统计量和Cochrane’s q检验评估异质性，并进行亚组分析和敏感性分析以确定异质性的来源。结果纳入了11项荟萃分析，包括50个数据集。结果表明，微型螺钉显著增加了磨牙间宽度（ES: 2.61 mm, 95% CI: 0.29-4.92, p = 0.02）和骨骼宽度（ES: 3.33 mm, 95% CI: 1.37-5.29, p = 0.001）。然而，MARPE前后对释磨牙宽度和牙槽宽度没有显著影响。微种植体显著减少磨牙移动（ES:−1.13 mm, 95% CI:−1.99至−0.26,p = 0.01）。在几个结果中发现了实质性的异质性（I²> 50%），尽管进行了亚组分析，但这种异质性仍然存在。结论微型螺钉和微型种植体在正畸治疗中可提高骨和磨牙间宽度，控制磨牙运动。然而，它们对其他结果的影响是不一致的，需要进一步的高质量研究来加强临床推荐。试验注册：PROSPERRO （CRD42023447137）。
The Impact of Mini-Screws and Micro-Implants on Orthodontic Clinical Outcomes: An Umbrella Meta-Analysis
Objectives
This umbrella meta-analysis aimed to answer the clinical question: Do mini-screws and micro-implants improve specific orthodontic outcomes such as intermolar width, interpremolar width, suture expansion, molar movement, and skeletal width compared to conventional anchorage methods?
Materials and Methods
A systematic search was performed in PubMed, Scopus, ISI Web of Science, and Google Scholar up to October 2024. Systematic reviews and meta-analyses on mini-screws and micro-implants in orthodontic treatment were included. Methodological quality was assessed using AMSTAR 2, and a random-effects model was used to calculate effect sizes (ESs) and 95% confidence intervals (CIs). Heterogeneity was evaluated using the I² statistic and Cochrane's Q-test, with subgroup and sensitivity analyses conducted to identify sources of heterogeneity.
Results
Eleven meta-analyses comprising 50 data sets were included. The results indicated that mini-screws significantly increased intermolar width (ES: 2.61 mm, 95% CI: 0.29–4.92, p = 0.02) and skeletal width (ES: 3.33 mm, 95% CI: 1.37–5.29, p = 0.001). However, no significant impact was found on interpremolar width or alveolar width before and after MARPE. Micro-implants significantly reduced molar movement (ES: −1.13 mm, 95% CI: −1.99 to −0.26, p = 0.01). Substantial heterogeneity was noted across several outcomes (I² > 50%), which persisted despite subgroup analyses.
Conclusion
Mini-screws and micro-implants enhance skeletal and intermolar width and control molar movement in orthodontic treatment. However, their effects on other outcomes are inconsistent, warranting further high-quality studies to strengthen clinical recommendations.
期刊介绍：
Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.
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