Clinical and Experimental Dental Research最新文献

{"title":"Stress Distribution Pattern in Mandibular Overdenture Designs Supported by Three Dental Implants: A 3D Finite Element Analysis","authors":"Negin Aminianpour,&nbsp;Marzieh Alikhasi,&nbsp;Mostafa Shabanpour Kasari,&nbsp;Hashem Yousefi,&nbsp;Hakimeh Siadat","doi":"10.1002/cre2.70060","DOIUrl":"https://doi.org/10.1002/cre2.70060","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The purpose of this study was to assess the implant-supported overdenture stress distribution pattern in cancellous and cortical bone, dental implants, and prosthetic components, and its displacement by using finite element analysis (FEA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>An edentulous model of the mandible was designed with three dental implants placed at the sites of canine teeth and the midline. Six groups were designed with isolated (ball and locator) and splinted (conventional bar and a CAD/CAM milled bar with cast and screw ball) attachments with and without a cantilever using SolidWorks 2022 software. The stress distribution pattern in the surrounding bone, implants, and prosthetic components (attachments, caps, housings, and screws) was evaluated following the application of 150 N force vertically and 105 N load with a 30° angle relative to the first molar site using Abaqus/CAE 2021 software. The implant-supported overdenture displacement was also evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The ball attachment caused the highest stress in the attachments (363 and 896 MPa) and housings (375 and 1187 MPa) under vertical and oblique loadings, and cancellous bone (6 MPa under vertical loading). The pattern of stress distribution was variable following vertical and oblique loading in the cortical bone and dental implants in different groups. The locator attachment resulted in lower stress distribution in bone, implants, and prosthetic components. In splinted groups, the cantilever designs caused lower stress in bone, implants, and prosthetic components in comparison with designs without a cantilever. The conventional and milled bar did not show any mechanical difference.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Considering the stress distribution patterns, the locator attachment is preferred to the ball isolated attachment, and the cantilever design is preferred among the splinted types. Isolated attachments were more effective in controlling the displacement. Also, conventional and milled bars did not show any superiority over each other.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prosthetic Soft Tissue Management in Esthetic Implant Restorations, Part II: Post-surgical Considerations and Impression Techniques. A Narrative Review","authors":"Faezeh Atri,&nbsp;Kimia Nokar","doi":"10.1002/cre2.70097","DOIUrl":"https://doi.org/10.1002/cre2.70097","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This two-part review article delineates various techniques to enhance esthetic outcomes in anterior implant treatments. Part I concentrates on presurgical measures, case selection, implant placement, and restoration timing. Part II discusses postsurgical steps, the temporary restoration phase, the emergence profile contour, abutment types, and impression techniques.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A comprehensive search was conducted using Medline/PubMed, Embase, Scopus, and the Cochrane Library. The primary keywords included: “Dental Implants,” “Dental Prosthesis, Implant-Supported,” “Esthetics, Dental,” “Dental Impression Techniques,” and “Tissue Management.”</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Initially, 1472 studies were identified, from which 187 were selected based on publication year and title relevance. After removing duplicates, 84 abstracts were reviewed in full text, culminating in 59 studies being thoroughly analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The decision to deliver an immediate restoration following implant insertion depends on the primary stability. However, in cases where delayed restoration is chosen, it is essential to consider the potential collapse of the soft tissue. A temporary restoration phase could be beneficial to aid in rebuilding the soft tissue. After achieving the desirable level of soft tissue, several techniques are available to achieve a precise transfer of molded gingival architecture, including customized impression coping, injection of soft material around the provisional restoration in the master cast, and digital impression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Localization Accuracy of Electrically Evoked Dental Sensations","authors":"Nuha Ab Ashaibi,&nbsp;Andrew Graham Mason,&nbsp;Mark Prichard Hector,&nbsp;Pauline Maillou","doi":"10.1002/cre2.70012","DOIUrl":"https://doi.org/10.1002/cre2.70012","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Dental pain of odontogenic origin can be difficult to accurately locate to a specific tooth. This study aimed to determine how effectively volunteers could locate electrical stimuli applied to teeth in both the anterior and posterior regions of the upper arch.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This study was approved by the University of Dundee Research Ethics Committee (No. UREC15068). Experiments were performed on 19 healthy consenting volunteers (2 male and 17 female). Customized tooth electrodes were temporarily attached to five teeth, allowing single 1-ms electrical stimuli at two intensities (pain threshold [T] and suprathreshold [1.25T]) to be delivered randomly to any one of three teeth (three test teeth and two controls). Volunteers were asked to indicate the location of the stimulus by pointing with their fingers. This was repeated 18 times (nine times with two different stimulus intensities) in a random order using a counterbalancing scheme. Three sessions were required to include all test teeth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overall accuracy of localization anteriorly was 67% at intensity T and 66% at 1.25T. For the right and left posterior teeth, the accuracy was 55% and 47% at T and 44% and 42% at 1.25T, respectively. No statistically significant differences were detected at T (<i>p</i> = 0.35, Bonferroni-corrected Mann–Whitney <i>U</i> test, <i>α</i> = 0.01) and at 1.25T (<i>p</i> = 0.28, Bonferroni-corrected Mann–Whitney <i>U</i> test, <i>α</i> = 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Odontogenic pain was poorly localized even under highly controlled experimental conditions. Pain in posterior teeth may be more difficult to correctly locate compared to anterior teeth, particularly at higher intensities.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Time Pressure on the Quality of Fillings and Arousal Levels of Dentists","authors":"Kaisa M. Leinonen,&nbsp;Jukka Leinonen,&nbsp;Mohammed Al-Haroni,&nbsp;Jan-Are K. Johnsen","doi":"10.1002/cre2.70106","DOIUrl":"https://doi.org/10.1002/cre2.70106","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>We investigated the impact of time pressure on dentists' arousal levels and the immediate quality of composite resin fillings using two filling techniques in a simulated clinical setting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Forty-two dentists and dental students were randomized to fill an identical Class II cavity either with the bulk-fill base technique or the conventional incremental technique. The task was performed first under timing and then under time pressure. Arousal levels were investigated with a 100 mm visual analog scale (VAS) and a wireless wrist-mounted triaxial accelerometer. The surface porosity and marginal gaps on the approximal surfaces of the fillings were evaluated using a stereomicroscope and specific probes according to the FDI criteria for restoration evaluation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Time pressure significantly increased arousal overall (<i>F</i> = 14.98, <i>p</i> &lt; 0.05), and there was a significant effect of the experimental group on participants' arousal levels under time pressure (<i>F</i> = 7.78, <i>p</i> &lt; 0.05); Dunn–Bonferroni tests indicated significantly lower arousal levels (<i>p</i> &lt; 0.05) for the bulk-fill base technique (<i>M</i> = 4.53, SD = 2.17) compared to the conventional incremental technique (<i>M</i> = 6.68, SD = 1.86). The bulk-fill base technique showed superior quality under time pressure (X² = 4.71, <i>p</i> = 0.030). Less experienced operators achieved better quality with the bulk-fill base technique (Χ² = 5.62, <i>p</i> = 0.018), while operator experience did not correlate with arousal levels under time pressure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Employing the bulk-fill base technique under time pressure led to reduced operator arousal levels and improved the immediate quality of fillings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Relevance</h3>\u0000 \u0000 <p>The bulk-fill base technique shows promise in being resistant to common work environment factors in dentistry, such as time pressure and stress, without compromising the quality of fillings. Utilizing innovative techniques, such as the bulk-fill base technique, in a clinical setting can contribute to mitigating the operator's stress and enhancing the quality of care provided.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secretomes of Gingival Fibroblasts From Periodontally Diseased Tissues: A Proteomic Analysis","authors":"Anne Kari Smedås,&nbsp;Lovise Gangeskar Paris,&nbsp;Niyaz Al-Sharabi,&nbsp;Einar K. Kristoffersen,&nbsp;Mariano Sanz,&nbsp;Kamal Mustafa,&nbsp;Dagmar Fosså Bunæs,&nbsp;Siddharth Shanbhag","doi":"10.1002/cre2.70103","DOIUrl":"https://doi.org/10.1002/cre2.70103","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Cell secretomes represent a promising strategy for periodontal and bone regeneration. The objective of this study was to characterize the secretome of human gingival fibroblasts (GF) from periodontally diseased tissues (GF-perio) using proteomics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Conditioned media of GF-perio from periodontitis patients (<i>n</i> = 6, 48-h serum-free culture) were subjected to liquid chromatography with tandem mass spectrometry. Global profiles, differentially expressed proteins (DEPs), and functional/gene-set enrichment (FEA) were analyzed using bioinformatics. Selected bone regeneration-related proteins were additionally measured using a multiplex immunoassay. Conditioned media of GF from periodontally healthy subjects were used as a reference.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 1833 proteins were detected in GF-perio secretomes, including several growth factors, cytokines, chemokines, and extracellular matrix proteins important for wound healing and regeneration. Key bone-related cytokines (FGF2, MCP1, GPNMB, MMP2, IL6, IL8) were confirmed by an immunoassay. Compared to the reference group, 127 exclusive proteins and 73 DEPs (<i>p</i> &lt; 0.05) were identified in the GF-perio group. FEA revealed significant enrichment of “exosome” and “cytoplasm” related cellular components in GF-perio secretomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The secretome of GF from periodontally diseased tissues may hold therapeutic potential, with several proteins important for wound healing and regeneration, especially those related to exosome functions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Traumatic Dental Injuries on Oral Health-Related Quality of Life Among Primary School Children in Dar es Salaam","authors":"Gloria Leo,&nbsp;Kasusu Nyamuryekung'e,&nbsp;Febronia Kokulengya Kahabuka","doi":"10.1002/cre2.70105","DOIUrl":"https://doi.org/10.1002/cre2.70105","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Traumatic dental injuries (TDIs) are a significant concern in pediatric populations, affecting children's oral health-related quality of life (OHRQoL) and overall development. This study aims to examine TDI prevalence, types, risk factors, and impacts on OHRQoL among Tanzanian school children.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Employing a cross-sectional analytical approach, the study assessed TDIs in school children aged 8–10 in Ilala district, Tanzania, using a multistage cluster sampling technique. Data collection employed structured questionnaires and clinical examinations, applying Ellis and Davey's classification and the Child Perception Questionnaire (CPQ 8–10) for TDIs and OHRQoL assessments, respectively. Statistical analyses included frequency distributions, chi-square, Mann–Whitney and Kruskal–Wallis tests, and binary logistic regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 501 participants, 25.1% reported previous oral trauma with a TDI prevalence of 37.5%. Crown fractures were the most common injury (79.8%), with significant associations found between TDI prevalence and inadequate lip coverage (<i>p</i> = 0.037) and overjet (<i>p</i> &lt; 0.001). Over 60% experienced an oral impact, notably in oral symptoms (52.5%), emotional well-being (25.1%), and functional limitation (22.8%) domains. Children with TDIs showed higher OHRQoL impacts on emotional and social well-being domains.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The high prevalence of TDIs among Tanzanian school children significantly impacts their OHRQoL, emphasizing the need for comprehensive pediatric dental care approaches that encompass preventive strategies and address the multifaceted aspects of oral health.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Xylitol and Fluoride Varnish on Biofilm and Saliva in Orthodontic Patients: A Triple-Blind Randomized Clinical Trial","authors":"Neda Babanouri,&nbsp;Sarina Sahmeddini,&nbsp;Setayesh Khadang,&nbsp;Abdollah Bazargani","doi":"10.1002/cre2.70062","DOIUrl":"https://doi.org/10.1002/cre2.70062","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Fixed orthodontic appliances are associated with higher levels of plaque and saliva bacteria, which contribute to dental caries. The effects of combining xylitol and fluoride, both used in caries prevention, are uncertain. Thus, this study assessed the combined impact of fluoride and xylitol varnish on bacteria in saliva and biofilms around orthodontic brackets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A single-center, four-arm, parallel-group, triple-blind, randomized clinical trial was conducted. A total of 120 patients who required fixed orthodontic treatment were included. Patients were sorted into one of the following groups at random: fluoride, xylitol, combined fluoride and xylitol, and control. Biofilm and saliva sampling was performed at two intervals: T0 (first session of bracket bonding, before application of the varnish) and T1 (6 weeks after application of the varnish). The number of <i>Streptococcus mutans</i> and <i>Lactobacillus</i> was counted using the CFU method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The relative number of <i>S. mutans</i> and <i>lactobacilli</i> in saliva and biofilm significantly decreased following the application of fluoride and combined fluoride/xylitol varnish (<i>p</i> &lt; 0.05) and were more effective than xylitol varnish. There was no significant difference between fluoride and combined fluoride/xylitol varnishes regarding changes in <i>S. mutans</i> and <i>Lactobacillus</i> colonies in saliva and dental biofilms. Additionally, there was no significant difference between xylitol and the two other active varnishes regarding reduction in biofilm <i>S. mutans</i> and <i>Lactobacillus</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>There was no significant difference between fluoride and combined fluoride/xylitol varnishes regarding changes in the studied bacteria in saliva and dental biofilms, and they were more effective than xylitol varnish.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>The Iranian Registry of Clinical Trial identifier: IRCT20181121041713N4; https://fa.irct.ir/trial/58543</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Tooth Development in Patients With Unilateral Cleft Lip and Palate","authors":"Marie Schwarting,&nbsp;Heinrich Wehrbein,&nbsp;Irene Schmidtmann,&nbsp;Christina Erbe,&nbsp;Susanne Wriedt","doi":"10.1002/cre2.70086","DOIUrl":"https://doi.org/10.1002/cre2.70086","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of this study was to investigate tooth development in patients with unilateral cleft lip and palate (UCLP) and unilateral cleft lip and alveolus (UCLA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A retrospective case–control study was carried out; 180 panoramic radiographs (OPGs) from non-syndromic patients (160 UCLP, 20 UCLA) treated at the University Medical Center Mainz (2019–2022) were analyzed. Patients were matched to a control group by calendar age, gender, and ethnicity. Inclusion criteria were verified through clinical data, photographs, and radiographs. No follow-up was conducted for this study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The cleft group showed a significantly lower dental age compared to the control group (10.72 ± 2.65 vs. 11.41 ± 2.79; <i>p</i> = 0.017), with a mean difference of 0.69 years (95% CI: 0.13–1.25 years). Tooth development was slower on the cleft side (<i>p</i> = 0.001), and maxillary teeth lagged behind mandibular teeth (<i>p</i> &lt; 0.001). The difference in the control group was somewhat smaller, with a mean difference of 0.11 degrees of mineralization in the control group compared to 0.25 degrees of mineralization in the cleft group. In UCLP patients, significant mineralization differences were noted for the lateral incisors (<i>p</i> = 0.004), the central incisor (<i>p</i> = 0.047), and canine (<i>p</i> = 0.030).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Patients with unilateral clefts show delayed tooth development and dental age, particularly in the affected quadrant. In everyday treatment, attention should be paid to a later start of orthodontic tooth movement to avoid damaging the slower developing roots.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Success of a Mineral Trioxide Aggregate and a Pre-Mixed Bioceramic in Mature Teeth With Irreversible Pulpitis With Full Pulpotomy: A Randomized Clinical Trial","authors":"Sarang Suresh,&nbsp;Feroze A. Kalhoro,&nbsp;Priya Rani,&nbsp;Mahwish Memon","doi":"10.1002/cre2.70090","DOIUrl":"https://doi.org/10.1002/cre2.70090","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of this study is to compare the clinical and radiographic success of MTA versus EBRRM in pulpotomy of permanent teeth with irreversible pulpitis without apical periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Clinical and radiographic assessments were conducted at baseline, 6 days, 6 weeks, and 6 months. After administration of anesthesia and coronal pulp removal, pulp was capped with MTA or Endo Sequence Bioceramic Root Repair, followed by restoration with a glass ionomer and resin composite.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overall success rate for pulpotomy was 71.9%, with MTA and the bioceramic showing success rates of 32.8% and 39.1%, respectively. There was no significant relationship with the type of cavity and failure of pulpotomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>MTA and EBBRRM are both practical choices for pulpotomy and there is no notable difference between them in the success rate and pain level. EBBRRM may be more effective in Class 1 cavities than in Class 2 cavities.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxicity of Different Concentrations of Silver Nanoparticles and Calcium Hydroxide for MC3T3-E1 Preosteoblast Cell Line","authors":"Farzaneh Afhkami,&nbsp;Paniz Ahmadi,&nbsp;Golriz Rostami","doi":"10.1002/cre2.70075","DOIUrl":"https://doi.org/10.1002/cre2.70075","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>With the advances in nanotechnology, nanomaterials are increasingly used in various fields due to their antibacterial properties; therefore, assessing the benefits and risks associated with the application of medicaments is imperative. This study evaluated the cytotoxicity of different concentrations of silver nanoparticles (AgNPs) and calcium hydroxide (CH) for MC3T3-E1 preosteoblast cell line.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>The MC3T3-E1 preosteoblast cells were exposed to triple antibiotic paste (TAP), AgNPs, CH, and different concentrations of AgNPs mixed with CH in 1:1, 1:2, and 1:3 ratios for 24, 48, and 72 h. Cytotoxicity was evaluated by the methyl thiazolyl tetrazolium (MTT) assay, and also the colony formation assay (CFA) was performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At 24 h, the TAP and AgNPs groups showed the highest and the CH-AgNPs/1:3 group had the lowest cell viability percentage in comparison to the other experimental groups. At 48 h, the TAP group showed the highest and the CH-AgNPs/1:3 group showed the lowest cell viability. At 72 h, the AgNPs and CH groups showed the highest viability, while the lowest viability was noted in the CH-AgNPs/1:3 and CH-AgNPs/1:2 groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>AgNPs showed the least cytotoxic effects in all periods. The addition of AgNPs to CH increases the cytotoxic effects of CH on experimental cells. After 48 and 72 h, CH-AgNPs/1:1 showed significantly higher cell viability in comparison to higher concentrations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}