Clinical and Experimental Dental Research最新文献

{"title":"Association Between Periodontal Disease and Cumulative Coping Challenges: A Retrospective Cross-Sectional Exploratory Educational Study","authors":"David C. Johnsen,&nbsp;Lauren A. G. Erickson,&nbsp;Derek Smith,&nbsp;Carlos Garaicoa-Pazmino","doi":"10.1002/cre2.70457","DOIUrl":"10.1002/cre2.70457","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Scarce scientific evidence is available on the association of cumulative coping challenges and periodontitis. The present retrospective cross-sectional exploratory study explored a new method to depict the association between periodontal disease (extent/severity/rate of progression) and cumulative coping challenges.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A population sample was identified with an array of periodontal disease levels and coping challenges within an academic setting. In January 2026, a total of 39 student-led patient presentations were recorded using an ordinal scale based on the 2017 American Academy of Periodontology/European Federation of Periodontology framework of staging/grading and a cumulative coping challenges score, including biologic, sociologic, behavioral, demographic, and oral disability-related factors. Spearman's correlation analysis was used to correlate periodontal disease level and cumulative coping challenges.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A distinct and significant association was found between level of periodontal disease and cumulative coping challenges (Spearman's <i>ρ </i>= 0.77, 95% CI, <i>p</i> &lt; 0.01). Clusters of patients depicted that those with mild forms of periodontal disease (Stages I–II) had few coping challenges and another group with severe forms of periodontal disease (Stages III–IV) harbored higher cumulative coping challenges. No person appeared with high disease and low cumulative coping challenges, and only one person appeared with low disease and high coping challenges.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This retrospective cross-sectional exploratory study quantified risk factors from a series of cumulative coping challenges resulting in a single metric to be correlated with disease level based on the current staging/grading system for periodontal diseases. Periodontitis was observed among individuals with minimal disease and few coping challenges, and another group with severe stages and extensive coping challenges. Despite the theoretical limitation of the proposed scale, the present model has a practical use in an educational setting as an exploratory composite index.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occlusal Adjustment in Free-End Implant-Supported Restorations: Digital Scans Versus Conventional Impressions With Full- and Half-Arch Techniques","authors":"Mohammadreza Nakhaei,&nbsp;Hossein Dashti,&nbsp;Arsalan Shahri,&nbsp;Mahsa Rahmani,&nbsp;Ali Kazemian,&nbsp;Saeid Sabzevari,&nbsp;Masih Rezaee","doi":"10.1002/cre2.70454","DOIUrl":"10.1002/cre2.70454","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To quantify the occlusal adjustment required for two-unit, implant-supported polymethyl-methacrylate (PMMA) crowns with either digital or conventional impression techniques, using full-arch and half-arch workflows.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Material and Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;An acrylic maxillary–mandibular model carrying two bone-level implant analogs (sites 46–47) was mounted on a semi-adjustable articulator. Twenty impressions were made (&lt;i&gt;n&lt;/i&gt; = 5 per group): digital full-arch, digital half-arch, conventional full-arch, and conventional half-arch. PMMA crowns were designed using computer-aided design (CAD) software, milled, and surface-scanned before adjustment. Occlusal contacts were refined on the articulator with 21 µm film while recording adjustment time. Pre- and post-adjustment scans were superimposed and analyzed using three-dimensional surface analysis software to quantify mean material reduction (µm). Data were analyzed with one-way ANOVA and independent-samples &lt;i&gt;t&lt;/i&gt;-tests (&lt;i&gt;α&lt;/i&gt; = 0.05).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Digital workflows required significantly less occlusal reduction (146 ± 35 µm vs. 226 ± 35 µm; &lt;i&gt;p&lt;/i&gt; = 0.035) and shorter adjustment times (144 ± 36 s vs. 385 ± 36 s; &lt;i&gt;p&lt;/i&gt; &lt; 0.001) than conventional, with no effect of arch span (full vs. half; &lt;i&gt;p&lt;/i&gt; &gt; 0.05). Within protocols, the digital half-arch group showed the smallest adjustment (127 ± 37 µm) and fastest finishing (98 ± 33 s), whereas the conventional half-arch group required the longest time (456 ± 21 s).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Fully digital impressions reduce both the amount of occlusal adjustment and the chairside time needed to seat implant-supported crowns compared with conventional silicone impressions. Reducing the scan to a half-arch does not compromise occlusal precision, making the digital half-arch workflow an efficient alternative for posterior, free-end implant restorations.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Clinical Relevance&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In implant posterior PMMA crowns, the impact of impression/workflow choice on occlusal adjustment is unclear. This in-vitro study measured occlusal reduction and chairside time across digital versus conventional and full- versus half-arch workflows. Digital, especially half-arch, required less adjustment and shorter time. Clinically, a digital half-arch approach may streamline delivery and reduce unnecessary material removal,","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70454","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accessing Polyphenols Effect on Bond Strength and Dentin Enzymatic Degradation","authors":"Ana Catarina Rios Castro Alves,&nbsp;Adonias Antonio da Silva,&nbsp;Roberta Bruno da Silva,&nbsp;Rayan de Lima França,&nbsp;Dayse Andrade Romão,&nbsp; de Fragoso,&nbsp;Natanael Barbosa dos Santos,&nbsp; de Porto","doi":"10.1002/cre2.70449","DOIUrl":"10.1002/cre2.70449","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Polyphenols have been investigated in dental materials and restorative techniques due to their interactions with metal cations, antioxidant activity, and collagen crosslinking ability, which make them a promise for reinforcing the dental substrate and improving material adhesion. However, more studies are necessary before to support their use in clinical procedures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study evaluated the effects of quercetin and resveratrol on bond strength and the protection of dentin collagen fibrils against enzymatic degradation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Demineralized human dentin specimens were immersed for 1 min in solutions of quercetin or resveratrol (100, 250, and 500 µg/mL), 2% chlorhexidine (CHX), or 0.9% saline (control). The specimens were then incubated in collagenase for 24 h at 37°C, and changes in dry mass were measured. For microtensile bond strength testing, quercetin, resveratrol, CHX, or distilled water (DW) were applied to phosphoric acid–conditioned dentin, followed by application of Single Bond 2 (3 M/ESPE) adhesive and Z350XT resin (3 M/ESPE). Adhesive strength was measured after 24 h and after 1 year in distilled water. Data were analyzed using the Kruskal–Wallis and Dunn tests or ANOVA followed by Tukey's test (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Quercetin-treated specimens showed a significant weight increase compared with CHX (<i>p</i> &lt; 0.05). Both quercetin- and resveratrol-treated groups exhibited resistance to collagenase similar to CHX (<i>p</i> &gt; 0.05). After 1 year, only the DW group showed a significant decrease in bond strength (<i>p</i> = 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Dentin treatment with quercetin or resveratrol effectively preserved adhesive strength and protected collagen against enzymatic degradation, suggesting their potential as agents to improve the longevity of adhesive restorations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Vaping on Treatment Outcomes in Patients With Gingivitis, Periodontitis, and/or Peri-Implant Disease: A Systematic Review","authors":"Stacey May Gould,&nbsp;Catherine Anne Gilchrist,&nbsp;Hannah Dominique Gaza,&nbsp;Ibadat Kaur Sidhu,&nbsp;Kayleigh Jade Hugo,&nbsp;Rodrigo Rodrigues Amaral,&nbsp;João Martins de Mello-Neto","doi":"10.1002/cre2.70456","DOIUrl":"10.1002/cre2.70456","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This systematic review aimed to evaluate the effect of vaping on periodontal treatment outcomes for patients with gingivitis, periodontitis, and/or peri-implant disease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>An electronic database search was conducted using Ovid MEDLINE, PubMed, Scopus, and Web of Science, with no date restrictions. An electronic search was conducted through June 30, 2026. Two independent reviewers extracted data according to predefined inclusion criteria and performed screening and quality appraisal. The risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale and the Cochrane Risk of Bias tool.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seven studies were included, involving 640 participants: 168 vapers, 138 traditional cigarette smokers, and 334 non-smokers. There was no significant difference in clinical response to periodontal and peri-implant therapy between tobacco and e-cigarette users, both of whom fared worse than non-smokers. Immunological outcomes were similar between smokers and vapers, with some exceptions, such as higher TNF-α levels in e-cigarette users. No meta-analysis was performed due to the heterogeneity of the included studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Current limited evidence suggests that vaping may be associated with less favorable periodontal and peri-implant treatment outcomes compared with non-smoking, with trends resembling those observed in cigarette smokers. Further research is required to clarify the extent to which vaping affects treatment outcomes compared to cigarette smokers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Craniofacial Morphology and Dental Age Assessment in Pediatric Craniosynostosis: A Comparative Cross-Sectional Study","authors":"Nutthakarn Ratanasereeprasert,&nbsp;Yanisa Wongbanthit,&nbsp;Narin Intarak,&nbsp;Preeya Suwanwitid,&nbsp;Chutimont Teekavanich,&nbsp;Anand Marya,&nbsp;Guang Hong,&nbsp;Thantrira Porntaveetus","doi":"10.1002/cre2.70445","DOIUrl":"10.1002/cre2.70445","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To delineate the craniofacial morphometric characteristics of Thai children with syndromic (SC) and non-syndromic craniosynostosis (NSC) and to assess dental maturation relative to Chronological Age (CA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This comparative cross-sectional study evaluated 19 patients (SC: <i>n</i> = 13; NSC: <i>n</i> = 6; mean age 9.32 ± 2.67 years). Seventeen skeletal and dental cephalometric variables were analyzed against age-matched ethnic norms. Dental age (DA) was quantified using the modified Demirjian's four-tooth method, calibrated via the Thai-specific Duangto model. One-sample and Welch's <i>t</i>-tests compared DA with CA and skeletal parameters with normative data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>SC patients demonstrated significant maxillary retrusion and midface hypoplasia, characterized by reduced SNA (73.63 ± 9.52°), ANB (−7.1 ± 10.51°), and maxillary depth (79.36 ± 11.2°) compared to normative data (<i>p</i> &lt; 0.05). Additionally, the SC group exhibited a hyperdivergent growth pattern (increased FMA: 32.61 ± 6.87°), a shortened anterior cranial base (41.47 ± 4.56 mm), and compensatory mandibular incisor retroclination (IMPA: 88.38 ± 8.57°) (<i>p</i> &lt; 0.05). In contrast, the NSC phenotype was primarily localized to a shortened anterior cranial base (48.17 ± 5.66 mm, <i>p</i> &lt; 0.05), with other skeletal parameters remaining within normative ranges. When evaluating dental maturation relative to chronological age, no statistically significant differences were detected in either cohort (mean difference: SC = 0.09 ± 1.50 years, <i>p</i> &gt; 0.05; NSC = 1.23 ± 1.61 years, <i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Children with SC present with severe multi-planar skeletal discrepancies and secondary dental compensations, whereas NSC-related dysmorphology is primarily confined to the cranial base. No statistically significant differences were detected between DA and CA in either group. Because dental development does not necessarily reflect the extent of craniofacial skeletal discrepancies, treatment timing must instead rely on comprehensive, patient-specific structures and skeletal malocclusion.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13573083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Treatments With Prevalence and Incidence of Periodontitis","authors":"Anna Liisa Suominen,&nbsp;Tuomas Saxlin,&nbsp;Marja-Leena Lamidi,&nbsp;Virva Vänttinen,&nbsp;Johanna Pasanen,&nbsp;Tiina Laatikainen","doi":"10.1002/cre2.70452","DOIUrl":"10.1002/cre2.70452","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim was to evaluate how treatment supplied in public oral health care services is associated with the prevalence and incidence of periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The data for this study comprised patients aged 20 years or older who had visited publicly funded oral health care services in the Wellbeing Services County of North Karelia (Siun sote) during the years 2021–2022 (<i>N</i> = 50,469). These patients were retrospectively followed in the patient register starting from 2014. Associations of treatments received during the follow-up period (years 2014–2020) with ICD-10 diagnoses of chronic and acute periodontitis at follow-up (in 2021–2022) were analyzed by logistic regressions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The prevalence of diagnoses of both chronic and acute periodontitis in 2021–2022 was quite low. The number of years of having received different treatments in 2014–2020 was associated with the odds of being diagnosed with periodontitis in 2021–2022. In the case of chronic periodontitis, an increasing number of years with preventive and restorative treatments was particularly associated with lower prevalence and incidence. Conversely, an increasing number of years with periodontal treatments and tooth extractions, in addition to earlier diagnosis, were associated with higher prevalence and incidence. For acute periodontitis, in contrast, an increasing number of years with preventive care among all participants and periodontal treatment in incident cases appeared to slightly increase the odds, whereas more years of examinations and tooth extractions were associated with reduced odds. In addition, smoking and diagnosis of diabetes mellitus were associated with higher odds of periodontitis diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>While the association of treatments was similar for prevalence and incidence, it differed between chronic and acute periodontitis, highlighting their distinct pathophysiological profiles. Although preventive care is offered less frequently than other treatments and often for reasons unrelated to periodontal health, it shows a positive impact in reducing the risk of chronic but not acute periodontitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining Electronic Health Records to Investigate Sex Differences in Oral Diseases and Conditions","authors":"Emma Fetchko,&nbsp;Linda Sangalli,&nbsp;Ariadne Letra","doi":"10.1002/cre2.70455","DOIUrl":"10.1002/cre2.70455","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Sexual dimorphism has been shown to influence disease predisposition and/or progression, although population-based studies in dental, oral, and craniofacial (DOC) diseases and conditions are limited. This study aimed to identify sex-based differences in DOC diseases/conditions using two large health data repositories.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective cross-sectional study of health record data obtained from adult participants (&gt; 18 years old) in the NIH <i>All of Us</i> Research Program (<i>n</i> = 254,700) and the BigMouth Data Repository (<i>n</i> ≈ 4.7 million). The number of males and females presenting each selected condition in each database was recorded. Sex-specific association analysis for each condition was performed using chi-square tests (α ≤ 0.0002). Female-to-male odds ratio (OR) and confidence intervals were also calculated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant sex-related differences were found for 61/87 concepts (70%), with 33 concepts (54%) showing female bias and 28 (46%) showing male bias (<i>p </i>≤ 0.0002). Analysis of BigMouth data showed sex bias for 90/230 (39%) concepts investigated, of which 87 (97%) showed female bias and 3 (3%) showed male bias (<i>p </i>≤ 0.0002).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study provides evidence of sex bias in numerous oral and dental conditions in the populations studied. Additional studies in other populations might provide further insight into the role of sexual dimorphism in these conditions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Patient Behavior and Clinician Emotional Burden, Perceived Performance, and Decision-Making in Implant Dentistry: A Cross-Sectional Study Among Clinicians","authors":"Aspasia Pachiou,&nbsp;Viviane Laura Humm,&nbsp;Nadja Naenni,&nbsp;Eleana Kontonasaki,&nbsp;Ronald E. Jung,&nbsp;Daniel S. Thoma","doi":"10.1002/cre2.70450","DOIUrl":"10.1002/cre2.70450","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the association between patient behavior and clinician emotional burden, perceived clinical performance, interaction difficulty, and decision-making in implant dentistry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A cross-sectional online questionnaire was distributed via individual invitations to 150 dental professionals involved in implant dentistry. A total of 127 clinicians completed the survey (response rate: 84.7%). The questionnaire assessed demographic and professional characteristics, clinicians’ perceptions of patient behavior, emotional responses, and the perceived impact of patient-related factors on clinical performance and decision-making. Composite domains for emotional burden and interaction difficulty were developed, and their internal consistency was assessed using Cronbach's <i>α</i>. Associations were evaluated using Spearman's correlation and linear regression analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>More challenging patient behavior was significantly associated with increased emotional burden (<i>ρ</i> = 0.50, <i>p</i> &lt; 0.001) and interaction difficulty (<i>ρ</i> = 0.46, <i>p</i> &lt; 0.001). Similar findings were observed when patient behavior was compared with usual clinical cases (both <i>p</i> &lt; 0.001). Procedural difficulty showed only weak or non-significant associations with emotional burden and interaction difficulty. Emotional burden was strongly associated with interaction difficulty (<i>ρ</i> = 0.84, <i>p</i> &lt; 0.001), avoidance of scheduling similar patients (<i>ρ</i> = 0.47, <i>p</i> &lt; 0.001), and lower perceived clinical performance (<i>ρ</i> = 0.27, <i>p</i> = 0.002). Regression analyses confirmed that patient behavior was significantly associated with emotional burden (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Patient behavior appears to be associated with clinician emotional burden and perceived clinical performance more strongly than case difficulty in implant dentistry.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collagen Substitutes in Oral Soft Tissue Augmentation: An In Vitro–Ex Vivo Study on Expansion and Elasticity","authors":"Leonardo Mancini,&nbsp;Stephanie Wenk,&nbsp;Lorenzo Tavelli,&nbsp;Ronald E. Jung,&nbsp;Nadja Naenni,&nbsp;Daniel S. Thoma","doi":"10.1002/cre2.70448","DOIUrl":"10.1002/cre2.70448","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to evaluate the hydration-induced volumetric expansion and elasticity of collagen-based soft tissue substitutes following exposure to blood using three-dimensional (3D) analysis and high-frequency ultrasonography (HFUS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Seven commercially available collagen matrices were analyzed: Fibro-Gide (6 mm and 3 mm), Mucogain (5 mm and 3 mm), Volumax, Collagen Graft II, and Mucograft. The investigation consisted of two experimental phases. In the in vitro phase, samples were immersed in stabilized porcine blood to assess absorption index (AI), 3D volumetric changes, and ultrasonographic (HFUS) parameters, including density and elasticity. In the ex vivo phase, matrices were placed beneath envelope flaps in porcine maxillae, with optical 3D scanning performed before and after blood saturation. Statistical analysis included generalized estimating equations for repeated measures and nonparametric testing, with significance set at <i>α</i> = 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Volume stable matrices exhibited significantly greater absorption and volumetric expansion compared to non-stable matrices. Fibro-Gide 6 mm demonstrated the highest absorption index (17.0 ± 0.6 mg) and volumetric increase (268.4 ± 54.8 mm³), while Mucogain 5 mm showed the greatest vertical expansion (0.83 ± 0.08 mm). Non-stable matrices displayed reduced expansion or partial collapse. A positive, though non-significant, correlation was observed between density (HFUS) and volumetric expansion (<i>r</i> = 0.29, <i>p</i> = 0.535).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Volume-stable collagen matrices show pronounced fluid uptake and expansion. Clinically, this effect should be considered, as excessive swelling may increase flap tension and compromise wound stability, necessitating careful trimming and adequate flap release.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning Prediction of Anterior Open-Bite Development After Stabilization Splint Treatment in Temporomandibular Disorder","authors":"Jae Joon Hwang,&nbsp;Hye-Mi Jeon,&nbsp;Hye-Min Ju,&nbsp;Sung-Hee Jeong,&nbsp;Yong-Woo Ahn,&nbsp;Soo-Min Ok","doi":"10.1002/cre2.70447","DOIUrl":"https://doi.org/10.1002/cre2.70447","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To develop interpretable machine learning (ML) models for risk stratification of clinically meaningful anterior overbite decrease after stabilization splint therapy in temporomandibular disorder (TMD) patients, and to compare ML performance with conventional logistic regression.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Materials and Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This retrospective cohort included 87 TMD patients treated with stabilization splints, physical therapy, and pharmacologic therapy. Thirty-five pre-treatment cephalometric and demographic features were used. The primary outcome was overbite difference (OD = post-treatment minus pre-treatment overbite). For classification, patients were labeled as Decrease (OD &lt; −0.5 mm; &lt;i&gt;n&lt;/i&gt; = 37) versus Non-Decrease (OD ≥ −0.5 mm; &lt;i&gt;n&lt;/i&gt; = 50), combining No Change and Increase due to severe imbalance in the Increase subgroup. Six classifiers (logistic regression, random forest, extreme gradient boosting (XGBoost), Light Gradient Boosting Machine, support vector machine, k-nearest neighbors) were evaluated using stratified fivefold cross-validation and leave-one-out cross-validation. Class imbalance was handled using class-weighting and the Synthetic Minority Over-sampling Technique (SMOTE) applied within the cross-validation loop. For regression, nine algorithms were tested to predict continuous OD. Model explainability was assessed using SHapley Additive exPlanations (SHAP).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In fivefold cross-validation, XGBoost achieved the best discrimination (AUC = 0.734), outperforming logistic regression (AUC = 0.611). With SMOTE, the random forest achieved a comparable AUC (0.735) with improved sensitivity. Across regression models, cross-validated R&lt;sup&gt;2&lt;/sup&gt; values were near-zero or negative, indicating limited ability to predict the exact magnitude of overbite change from baseline variables alone. SHAP ranked pre-treatment overbite, ramus height, upper occlusal plane to SN angle, sella-to-condylion distance, and condylar positional indices among the most influential predictors for classification.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Interpretable ML enables improved risk stratification for clinically meaningful anterior overbite decrease after stabilization splint therapy in TMD patients, whereas predicting the exact magnitude of overbite change remains limited using pre-treatment cephalometrics alone. These models may support individualized counseling and closer monitoring for patients at higher risk of open-bite development duri","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70447","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}