Clinical and Experimental Dental Research最新文献

{"title":"Modified Coronally Advanced Tunnel Technique With Porcine Dermal Matrix for Recession Treatment: 12-Month Follow-Up","authors":"Erik Würflein,&nbsp;Sebastian Ollinger,&nbsp;Anton Sculean,&nbsp;Kirstin Vach,&nbsp;Victoria Constanze Landwehr,&nbsp;Katja Nelson,&nbsp;Betül Dursun,&nbsp;Susanne Nahles,&nbsp;PD Gerhard Iglhaut,&nbsp;Tobias Fretwurst","doi":"10.1002/cre2.70199","DOIUrl":"https://doi.org/10.1002/cre2.70199","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To assess the efficacy of the modified coronally advanced tunnel technique (MCAT) with a porcine dermal matrix (PDM) after a 12-month follow-up. There are no other Clinical trials evaluating a PDM over the period of 12 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Patients with recession type (RT) 1 and RT 2 gingival recessions were treated with the MCAT and a novel PDM. Plaster casts (preoperative and 12 months postoperative) were scanned using a 3Shape Lab Scanner E3. The resulting STL files were imported and superimposed in the open-source software GOM Inspect for analysis. Measurements included recession depth, mean root and total root coverage (mRC and cRC), mean recession reduction (mRR), and gingival thickness. Statistical analysis was performed using mixed linear models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 77 teeth (19 patients) were included in the study. Healing was uneventful in all patients. The mean preoperative recession depth was 1.26 mm ± 0.86 mm. mRC was 69.47% ± 61.90%, cRC was 29.79%, mRR was 0.87<span> ±</span> 0.83 mm, and gingival thickness gain was 0.23 ± 0.24 mm, with comparable results for RT 1 and RT 2. Neither tooth type nor jaw type had any effect on root coverage.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The modified coronally advanced tunnel technique in combination with the analyzed porcine dermal matrix demonstrated stable results for root coverage and gingival thickness after 12 months of follow-up.</p>\u0000 \u0000 <p><b>Trial Registration:</b> Deutsches Register Klinischer Studien/German Clinical Trial Register (DRKS); DRKS00023201.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70199","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Neopterin and Interleukin-6 Detection in Saliva and Plasma in Oral and Oropharyngeal Cancer Patients: A Prospective Study","authors":"Lenka Šašková,&nbsp;Peter Tvrdý,&nbsp;Bohuslav Melichar,&nbsp;Josef Tomandl,&nbsp;Jana Zapletalová,&nbsp;Michal Mozol'a,&nbsp;Petr Michl,&nbsp;David Král,&nbsp;Richard Pink","doi":"10.1002/cre2.70202","DOIUrl":"https://doi.org/10.1002/cre2.70202","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The incidence of oral and oropharyngeal cancer is continually rising and affects increasingly younger patients. Consequently, many studies focus on early diagnosis using appropriate biomarkers. Neopterin and interleukin-6 (IL-6) are promising predictive and prognostic markers of immune response activation, both systemic and local, due to the anatomical proximity of malignancies to the salivary glands.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>We collected oral fluid samples from 50 patients before and after the surgical resection of squamous cell carcinoma of the oral cavity and oropharynx. Additionally, blood samples were withdrawn from 20 of these patients and levels of neopterin and IL-6 were estimated using ELISA commercial kits. All gathered data were subsequently statistically analyzed for evaluation and compared to values from a control group of healthy individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In patients with oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC), there was a significant decrease in neopterin and IL-6 levels in saliva following the surgical removal of the malignancy. These postoperative levels approached those of the control group. There was no significant decrease in neopterin and IL-6 levels in plasma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Detection of neopterin and IL-6 in saliva is a reliable diagnostic method for early detection of OSCC and its recurrence, as well as for monitoring therapeutic success, compared to plasma. Neopterin and IL-6 appear to be promising prognostic and predictive markers of the disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchrotron-Based Analysis of Conical Implant–Abutment Connections Under Mechanical Load: How Embedding Materials Influence the Microgap and Implant Shoulder Deformation","authors":"Florian Kernen,&nbsp;Katja Nelson,&nbsp;Simon Zabler,&nbsp;Alexander Rack,&nbsp;Fumihiko Watanabe,&nbsp;Tobias Fretwurst,&nbsp;Sina Wenger","doi":"10.1002/cre2.70179","DOIUrl":"https://doi.org/10.1002/cre2.70179","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Dental implants have become a reliable solution for oral rehabilitation, but their long-term success can be compromised by factors such as mechanical overload. To ensure the mechanical durability of implants, standardized testing in accordance with the DIN EN ISO 14801 is conducted, in which titanium implants (Young's modulus of approximately 100 GPa) are embedded in brass, a material with similarly high stiffness. However, the mechanical properties of brass differ significantly from those of alveolar bone, potentially affecting test outcomes. This study examines how different embedding materials affect the mechanical behavior of dental implants, specifically microgap changes and deformation at the IAC under load.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Two conical dental implants were embedded in either methyl methacrylate-based adhesive (PMMA) or brass. A 250 N load was applied at a 45° angle to the implants. Synchrotron-based microcomputed tomography (µCT) was used to assess microgap formation and 3D deformation at the implant shoulder before and under load application. Deformation was analyzed using Avizo Fire software to estimate volumetric changes at the implant shoulder.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed that implants embedded in brass exhibited larger microgap changes (53 μm) and greater deformation at the implant shoulder (32 μm) compared to those embedded in PMMA (microgap: 40 μm).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings suggest that brass, with higher stiffness than PMMA or bone, does not accurately replicate the mechanical conditions of bone, leading to a difference in microgap behavior and deformation at the implant shoulder, suggesting a difference in the wear mechanism and stress-strain distribution in the surrounding bone. These results question the use of brass in mechanical implant testing and highlight the need for more realistic embedding materials to improve the predictive value of implant testing.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70179","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional Relationship Between Dental Diseases and Sleep Disturbances in Pediatric Patients","authors":"Yaqiong Zhang,&nbsp;Wenqi Yang,&nbsp;Qi Sun,&nbsp;Fangkai Han,&nbsp;Minjun Dong","doi":"10.1002/cre2.70191","DOIUrl":"https://doi.org/10.1002/cre2.70191","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Certain dental diseases in pediatric patients may disturb their sleep, affect their oral health-related quality of life, and result in a negative influence on cognition and behavior. On the other hand, sleep disturbances may also increase the risk or participate in development and progression of dental diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This narrative review aimed to overview of the bidirectional relationship between common dental diseases and sleep disturbances, as well as the potential mechanisms behind.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>PubMed, Web of Science, and Google Scholar were searched using the keywords “dental disease,” “sleep disturbances,” and “children,” and only articles published in English were included.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Evidence provided by previous studies has indicated that common dental diseases, including dental caries, temporomandibular disorders, and dentofacial deformities, induced sleep disturbances in children and adolescents. On the other hand, common sleep disturbances such as sleep disordered breathing, obstructive sleep apnea, as well as other sleep problems, including sleep bruxism and sleep profile impairments, have a strong link to oral health conditions in pediatric patients. Alteration of oral microorganism colonization, impairment in the immune system, persistent inflammation, and chronic pain have contributed to sleep disorders triggered by these dental diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Upon identification of dental caries, gingivitis, periodontitis, as well as other dental problems, a checkup on a child's sleep is important, as this may subsequently affect his/her initiation, maintenance, duration, and quality of sleep. Dentists and orthodontists could play a critical role in early detection, prevention, and intervention of the dental health-related sleep disturbances.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RANKL, OPG, and CTS-K Release in Bone Response to Immediate Nonfunctional Loading of a Single Implant in Mandibular Molar Sites During Osseointegration Establishment","authors":"Xiaowen Hu,&nbsp;Yijie Fan,&nbsp;Xuexia Chen","doi":"10.1002/cre2.70193","DOIUrl":"https://doi.org/10.1002/cre2.70193","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To verify that osseointegration maturation under immediate restoration is correlative with active release of cytokines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>The participants needing the restoration of a single missing mandibular molar were randomized into immediate restoration (IR) and conventional restoration group (CR). All eligible patients were recalled for collecting peri-implant crevicular fluid (PICF) samples according to the scheduled follow-up time point during osseointegration and functional loading. Detection of receptor activator of nuclear factor-KB ligand, osteoprotegerin, and cathepsin K in PICF was conducted to statistically analyze their difference between IR and CR groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During the osseointegration period, the overall level of these cytokines in the IR group was statistically higher than that of the corresponding cytokine in the CR group. During functional loading, the overall level of the each cytokine in CR was statistically different from that of the corresponding cytokine during osseointegration, but the overall level of each cytokine was not statistically different between the two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The rapid osseointegration maturation under immediate restoration is probably correlative with active release of cytokines related with bone metabolism.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144814785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Immediate Dentin Sealing With Various Universal Adhesives on Shear Bond Strength of Dual-Cure Resin Cement","authors":"Malin Janson,&nbsp;Li Sun,&nbsp;Anja Liebermann,&nbsp;Christoph Matthias Schoppmeier","doi":"10.1002/cre2.70186","DOIUrl":"https://doi.org/10.1002/cre2.70186","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study evaluated the effect of universal adhesives (UAs) applied as Immediate Dentin Sealing (IDS) on the shear bond strength (SBS) of dual-cure resin cement, both immediately and after thermocycling aging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A total of 180 bovine incisors were prepared and randomly assigned to six groups (<i>n</i> = 15): NOC (control), Clearfil Universal Bond Quick (CUBQ), G-Premio Bond (GPB), Peak Universal Bond (PUB), Adhese Universal (AU), and Scotchbond Universal Plus (SBUP). Specimens were cemented with dual-cure resin cement (Panavia V5) and subjected to SBS testing at 24 h and after thermocycling (10,000 cycles, 5°C–55°C). SBS was measured using a universal testing machine, and failure modes were assessed microscopically. Statistical analysis was conducted using a Generalized Linear Model with Bonferroni correction (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant differences were found among UAs (<i>p</i> &lt; 0.001) and after aging (<i>p</i> &lt; 0.001). SBUP and GPB had the highest SBS before and after thermocycling, while NOC had the lowest. Thermocycling reduced SBS in all groups, with CUBQ and AU showing the largest declines. Failure mode analysis showed predominantly adhesive failures in NOC, while IDS groups had more cohesive and mixed failures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>IDS technique with universal adhesives significantly enhances bond strength to dentin compared to conventional cementation. SBUP and GPB showed superior bonding performance, likely due to their monomer formulations containing 10-MDP and acetone, which are known to improve chemical adhesion to dentin and promote effective resin infiltration. Thermocycling led to a reduction in SBS across all groups, highlighting the impact of aging on adhesive durability, underscoring the importance of selecting UAs with lasting adhesive strength for long-term bonding.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motivation for Smoking Cessation in Patients With Oral Squamous Cell Carcinoma—A One-Time Survey","authors":"Lennart Johannes Gruber,&nbsp;Matthias Maximilian Bühler,&nbsp;Antonie Spillner,&nbsp;Stefan Andreas,&nbsp;Philipp Kauffmann,&nbsp;Henning Schliephake,&nbsp;Susanne Wolfer","doi":"10.1002/cre2.70154","DOIUrl":"https://doi.org/10.1002/cre2.70154","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Tobacco smoking is one major risk factor in the development of oral squamous cell carcinoma (OSCC). Continuation of smoking after diagnosis and treatment is associated with an increase in recurrence rate and incidence of second tumors, with a shorter lon g-term survival and poorer response to therapy. In the current German guideline for the treatment of OSCC, there is no clear recommendation to participate in structured smoking cessation programs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A total of 202 patients with histologically confirmed OSCC completed a one-time assessment of their smoking behavior using three standardized questionnaires during regular tumor follow-up. In addition to sociodemographic data, patients were asked retrospectively about their smoking habits and motivation to quit smoking before and after diagnosis and treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A serious smoking cessation attempt before diagnosis of OSCC were stated in 54.8% of the participants. This number increased up to 82.2% after OSCC diagnosis. However, only 48.5% managed to quit smoking after diagnosis. Professional support was with only 21.92% (<i>n</i> = 16) rarely used. Motivation to quit was significantly lower before (2.75 ± 2.41) than after OSCC diagnosis (7.27 ± 2.41) (<i>p</i> = 0.001) and significantly higher among the participants who finally managed to quit (9.38 ± 1.68) than among those who continued smoking (4.79 ± 3.43) (<i>p</i> = 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The diagnosis of OSCC appears to be an important teachable moment for smoking cessation. To maximize this effect, an early and standardized implementation of systematic smoking cessation programs into the therapeutic concept of patients with OSCC is strongly recommended.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare Tumors of Oral Cavity: A Case Report and Literature Review on Secretory Carcinoma of Minor Salivary Glands","authors":"Emilio Salerno,&nbsp;Silvio Abati,&nbsp;Gianluigi Arrigoni,&nbsp;Daniela Finocchiaro,&nbsp;Giorgio Gastaldi,&nbsp;Alessandra Lissoni,&nbsp;Andrea Galli,&nbsp;Matteo Trimarchi","doi":"10.1002/cre2.70200","DOIUrl":"https://doi.org/10.1002/cre2.70200","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The primary objective of this study is to report and analyze two rare cases of secretory carcinoma (SC) of the minor salivary glands, focusing on their diagnostic and therapeutic work-up. The study aims to enhance scientific knowledge about SC, which is crucial for developing targeted therapies and ensuring precise diagnosis, especially differentiating it from acinic cell carcinoma (ACC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The study involved a detailed examination of two patients diagnosed with SC of the minor salivary glands. Clinical examinations, histological investigations, and immunohistochemical analyses were conducted. The treatment approach included surgical excision of the lesions followed by regular follow-ups to monitor for recurrence. Immunohistochemical analysis was performed to identify the presence of markers such as GATA3, SOX-10, NTRK, mammaglobin, and others.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Two cases are shown: a case of a 76-year-old male with a lesion in the hard palate was initially misdiagnosed as leukoplakia. After surgical excision and histological examination, the lesion was identified as SC. The patient underwent follow-up examinations, including MRI and CT scans, which showed no recurrence, and another case of a 39-year-old female with a nodule in the superior left vestibule underwent surgery to remove the nodule. Histological and immunohistochemical analyses confirmed SC, showing a high proliferation index and presence of the ETV6–NTRK3 gene fusion. Follow-up imaging showed no signs of disease recurrence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The study underscores the importance of precise diagnosis and differentiation of SC from ACC. Surgical excision followed by regular monitoring is effective in managing SC. Immunohistochemical and molecular analyses are crucial for accurate diagnosis. The findings contribute to the growing body of evidence on SC and highlight the potential for developing more targeted therapies. Further research is needed to establish clear guidelines for follow-up duration and treatment protocols.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70200","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144773888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Study of the Quality of Online Information on Periodontal Surgery","authors":"William Weng Nian Mak,&nbsp;Sushil Kaur,&nbsp;Maurice J. Meade","doi":"10.1002/cre2.70195","DOIUrl":"https://doi.org/10.1002/cre2.70195","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the quality of online information provided by dental-related websites regarding periodontal surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The term “Gum Surgery” was entered into three search engines (Google, Yahoo, and Bing). The content of websites satisfying selection criteria was assessed with five validated quality of information tools (DISCERN, The Patient Education Materials Assessment Tool [PEMAT], Journal of the American Medical Association [JAMA] benchmarks, and HONCode and @TRUST certification). The Simple Measure of Gobbledygook (SMOG) was used to evaluate the readability of content.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 55 websites satisfied selection criteria. The mean (SD) DISCERN score for all website categories was 2.89 (0.57). The quality of information related to the risks of each treatment scored poorly in most websites. The healthcare portals obtained the highest mean PEMAT score of 71.74%, a statistically significant outcome. Healthcare portal websites also recorded the highest mean (SD) JAMA score of 3.72 (0.75) out of 4. The mean (SD) SMOG score was 9.56 (1.07). Cohen's <i>κ</i> inter-rater reliability for DISCERN and PEMAT scores were 0.75 and 0.79, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The information available online about periodontal surgery was variable and difficult to read, falling short of established standards for accuracy, reliability, and credibility. Vital information was often omitted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144773724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of 3D-Printed Polylactic Acid as a Bone Substitute: An Animal Study in a Rat Model","authors":"Velayudhan Ashok,&nbsp;Mohanraj Karthik Ganesh,&nbsp;Subhabrata Maiti,&nbsp;Deepak Nallaswamy,&nbsp;Artak Heboyan","doi":"10.1002/cre2.70201","DOIUrl":"https://doi.org/10.1002/cre2.70201","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Bone repair and regeneration are important processes for treating bone defects and injuries. However, traditional bone grafts like autografts and allografts have limitations, such as complications at the donor site and immune rejection. As a result, there is growing interest in using polylactic acid (PLA), a biodegradable and biocompatible material, as a synthetic bone substitute. This study aims to evaluate the effectiveness of 3D-printed PLA scaffolds as bone substitutes using a rat model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>PLA scaffolds with dimensions of 2 × 2 × 4 mm and 2 × 2 × 8 mm were fabricated using the CUBEX-TRIO 3D printer. Twelve male Wistar rats were divided into four groups based on defect size (4 and 8 mm) and observation period (4 weeks and 8 weeks). The surgical procedures involved creating discontinuity defects in the rats' zygoma and implanting PLA scaffolds that were stabilized with a bio-membrane. Bone regeneration was assessed through radiographic analysis and histological examination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Radiographic analysis confirmed the formation of bone in the grafted regions. Histological analysis revealed connective tissue formation at the defect edges and scaffold surface at both 4 and 8 weeks. In the 4 mm defect group, the transformation of connective tissue into chondrocytes and endochondral ossification was observed at 8 weeks, indicating successful bone regeneration. However, in the 8 mm defect group, bone formation was not as evident, suggesting limitations in the osteoinductive potential of PLA scaffolds for larger defects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The 3D-printed PLA scaffolds show promise as bone substitutes for small to moderate-sized defects due to their effective biocompatibility and osteoinductive potential. Further studies are needed to optimize their performance for larger defects, potentially enhancing their clinical application in bone repair and regeneration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144773725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}