Clinical and Experimental Dental Research最新文献

{"title":"Effect of Low-Intensity Electrical Stimulation on External Apical Root Resorption and Periodontal Indices Following En-Masse Retraction of Upper Anterior Teeth in Young Adults: A Randomized Controlled Trial","authors":"Rashad I. Shaadouh, Mohammad Y. Hajeer, Mohammad Khursheed Alam, Samer T. Jaber","doi":"10.1002/cre2.70188","DOIUrl":"https://doi.org/10.1002/cre2.70188","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate external apical root resorption (EARR) and periodontal indices during en-masse retraction of maxillary anterior teeth stimulated with low-intensity electrical currents.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Design</h3>\u0000 \u0000 <p>A two-arm randomized controlled trial.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Young adult patients who visited the Department of Orthodontics at Damascus University between November 2023 and March 2024 and met predefined inclusion criteria were randomly allocated into two groups using block randomization. The study included 34 patients, with 17 assigned to the electrically stimulated en-masse retraction (ESER) group and 17 to the conventional en-masse retraction (CER) group. The force for the en-masse retraction technique in both groups was 250 g per side. The force was applied through bilateral closed-coil nickel-titanium springs anchored to an orthodontic mini-screw on each side. In the ESER group, each upper anterior tooth was subjected to a continuous electrical stimulation of 15–20 µA for 5 h daily, utilizing an intraoral removable electrical stimulation device. EARR was assessed using digital panoramic radiographs. Four periodontal indices were also used to assess periodontal status. Blinding was confined to data analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-four patients (26 females and 8 males) were analyzed with a mean age of 21.12 ± 2.41 years. At the end of the en-masse retraction phase, no significant difference in EARR was observed between the two groups (<i>p</i> > 0.05). The observed root resorption in the ESER and CER ranged between 0.27 and 0.64 and 0.32 and 0.71 mm, respectively. Also, insignificant differences were found in all periodontal indices studied at all measurement points between the two groups (<i>p</i> > 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Low-intensity electrical stimulation had no significant effect on root resorption during the en-masse retraction of the six upper anterior teeth. Both groups exhibited comparable slight root resorption without any significant difference between them. Additionally, low-intensity electrical stimulation did not affect the periodontal status during en-masse retraction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trail Registration</h3>\u0000 \u0000 <p>Clinical Trials database (NCT06873490).</p>\u0000 ","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70188","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144773889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Silver Diamine Fluoride Application Methods on Dentin Microhardness and Durability Under pH Cycling: An In Vitro Study","authors":"Farideh Darabi,&nbsp;Parmida Farzam,&nbsp;Mehrsima Ghavami-Lahiji","doi":"10.1002/cre2.70190","DOIUrl":"https://doi.org/10.1002/cre2.70190","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study investigated the effects of various application methods of silver diamine fluoride (SDF) on dentin microhardness and its durability under a 14-day acid challenge. The primary goal was to identify an optimal conservative SDF application protocol for clinical dentistry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Mid-coronal dentin disc samples from human premolars were prepared through two horizontal cuts and polished. Samples were randomly divided into three groups of ten: (1) SDF-NR (SDF applied for 3 min, excess removed with cotton); (2) SDF-R-R (SDF applied, rinsed, and polished after 24 h); (3) SDF-R (SDF applied for 3 min, then rinsed). Vickers microhardness was measured at three stages: initial, post-demineralization, and post-SDF application. In the second phase, a control group (no SDF) and a test group (SDF-R) underwent a 14-day pH-cycling regimen, with final hardness changes evaluated at a significance level of 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant microhardness increases were observed in all groups following SDF application compared to demineralized conditions (<i>p</i> = 0.001). Although the decrease in microhardness after acid challenge in the SDF group was less than in the control group, this difference was not statistically significant (<i>p</i> = 0.423).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Different SDF application methods significantly enhance dentin microhardness post-demineralization. Nevertheless, the acid challenge revealed minimal differences between the control and test group, indicating that reapplication of SDF may be necessary for sustained effectiveness.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70190","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Antimicrobial Properties of Different Dental Cleaning Tablets Against S. aureus Grown on Two Denture Base Materials","authors":"Sindi Vishaj,&nbsp;Alissa Villhauer,&nbsp;Mandi Morris,&nbsp;Donald M. Belles,&nbsp;Daher Antonio Queiroz,&nbsp;Maria D. Gonzalez,&nbsp;Ransome van der Hoeven","doi":"10.1002/cre2.70189","DOIUrl":"https://doi.org/10.1002/cre2.70189","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to evaluate the antimicrobial efficacy of three commercially available denture cleaning tablets Efferdent, Polident, and Val-clean against <i>Staphylococcus aureus</i> biofilms formed on two denture base materials: milled polymethyl methacrylate (PMMA) and 3D printed denture resin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Eighty samples were fabricated, with 40 specimens per denture base material: CAD/CAM milled PMMA (Lucitone Digital Fit LT; Dentsply Sirona, Charlotte, NC, USA) and 3D printed resin (Denture Base Resin; Formlabs Inc., Somerville, MA, USA). Each group was divided into four subgroups (<i>n</i> = 10), Efferdent, Polident, Val-clean, and deionized water (control). Surface roughness was measured using a digital profilometer (Digiprofilo I; Digiwork Instruments, Concord, ON, Canada). Samples were exposed to <i>S. aureus</i> in tryptic soy broth (TSB) and subsequently treated with the cleaning solutions. Colony-forming units (CFUs) were quantified using serial dilution plating. To distinguish bactericidal from bacteriostatic effects, normalized <i>S. aureus</i> cultures were incubated with the cleaning agents for 16 h, followed by optical density measurements, LIVE/DEAD staining (Invitrogen, Carlsbad, California), and TSB agar plating. Statistical analysis was performed using one-way ANOVA and Dunnett's multiple comparisons test, with significance set at <i>p</i> &lt; 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significant difference in surface roughness was observed between the 3D printed and milled samples before treatment (<i>p</i> &lt; 0.0001). Significantly fewer CFUs were observed in all cleaning solution groups compared to the control (<i>p</i> &lt; 0.05). All denture cleaning solutions demonstrated bactericidal activity against <i>S. aureus</i>, as indicated by the absence of CFU growth on agar plates and the lack of viable cells in LIVE/DEAD staining posttreatment. Both denture materials demonstrated comparable microbial adhesion and response to the cleaning agents.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Efferdent, Polident, and Val-clean denture tablets are effective bactericidal agents against <i>S. aureus</i> in vitro, regardless of the denture base material used. These findings support their use in daily denture hygiene routines, particularly in reducing bacterial colonization on removable prostheses.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Clinical Efficacy of the Application for Articulation Therapy-Thai (AAT-T) for Thai Children With Cleft Lip and Palate","authors":"Benjamas Prathanee,&nbsp;Sumita Duangprasert,&nbsp;Sasalaksamon Chanachai,&nbsp;Patorn Piromchai","doi":"10.1002/cre2.70194","DOIUrl":"https://doi.org/10.1002/cre2.70194","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Mobile applications are becoming essential for speech therapy, especially in areas with limited access to professional speech therapists. This technological intervention is especially pertinent during pandemics, which further restrict access to traditional therapeutic modalities. The objective of this study was to develop and evaluate a mobile application for articulation therapy, specifically designed for pediatric patients with articulation disorders associated with cleft palate.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>The articulation exercises incorporated in the application encompassed 27 Thai initial and final consonant sounds, presented through video demonstrations and tabular reading materials. These materials included nonsense syllables, words, phrases, and sentences. The content validity was assessed using the Item-Objective Congruence (IOC) index. Face validity and functional satisfaction were evaluated by a panel comprising four speech-language pathologists (SLPs), five children with cleft palate with or without cleft lip (CP ± L) and their respective caregivers, and an expert in application design. The clinical efficacy of the application for speech correction was subsequently assessed in a cohort of 19 children diagnosed with CP ± L.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The Application for Articulation Therapy-Thai (AAT-T) was finalized after four iterative revisions. The IOC index for the application ranged from 0.80 to 1.00, indicating strong content validity. Functional satisfaction scores ranged from 76% to 100%, suggesting high user acceptability. Nineteen children participated in the clinical efficacy assessment; however, one child was withdrawn due to the inability to complete 6-month follow-up. The results demonstrated that AAT-T significantly reduced articulation errors in connected speech (mean difference = 2.33, SD = 2.40, 95% CI = 1.14–3.53, <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The AAT-T application emerged as an accessible, engaging, and motivational tool for articulation practice. Its efficacy in speech correction was demonstrated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computer-Assisted Implant Surgery: Implications for Teaching, Learning, and Educational Strategies","authors":"Lin Jing Uei,&nbsp;Xin Hui Yeo,&nbsp;Yiu Yan Leung,&nbsp;George Pelekos,&nbsp;Bilal Al Nawas,&nbsp;Nikos Mattheos","doi":"10.1002/cre2.70197","DOIUrl":"https://doi.org/10.1002/cre2.70197","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This white paper aimed to discuss educational strategies for teaching and learning of computer-assisted implant surgery (CAIS) within the wider dental curriculum, including the pedagogy, technologies, and challenges.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A review of the available literature up to February 2025 was conducted, compiling existing evidence related to the application of CAIS in dental education, both through simulation and in clinical care. The findings were further integrated with expert opinions and current best practices in dental education in a panel discussion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Guided CAIS demonstrated potential to enhance implant placement accuracy and increase confidence among novice surgeons. Dynamic CAIS (d-CAIS) could support broader cognitive and surgical skill development, whereas static CAIS (s-CAIS) showed limited utility as a comprehensive educational instrument. The sequence of learning between guided and non-guided techniques appears to be less critical than ensuring proficiency in both. Competence development with d-CAIS is incremental, unlike s-CAIS, where progress might be faster but involves mainly procedural skills. Key challenges remain for the implementation of CAIS in educational structures such as limited faculty expertise, high costs of digital equipment, limited interoperability of digital systems, and ethical or legal concerns regarding autonomy of technologies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>CAIS has shown to be a valuable tool in teaching implant dentistry; its proper integration into dental education enhances the learners' experience and offers significant benefits for developing overall surgical competences. Current educational research is limited and primarily focused on the accuracy of implant placement, while practice of CAIS entails a very wide set of parameters encompassing the clinician, the workflow, the institution or clinic, and the patient. Future studies targeting educational interventions with a wider array of outcome measures would be required to help design effective educational strategies with CAIS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70197","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Crossover Clinical Trial Investigating 16-Branched Filament Toothbrush Effects on Dental Plaque Removal","authors":"Nozomi Niki,&nbsp;Makoto Fukui,&nbsp;Ichika Sone,&nbsp;Kosuke Kataoka,&nbsp;Moeno Takeshita,&nbsp;Keisuke Kato,&nbsp;Daisuke Hinode","doi":"10.1002/cre2.70192","DOIUrl":"https://doi.org/10.1002/cre2.70192","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Self-care using an appropriate toothbrush is important for oral health management. The aim of this clinical trial in older adults was to evaluate the effectiveness of a prototype toothbrush with 16-branched filament ends (16-BFE) in dental plaque removal compared to a toothbrush with super tapered filament (STF).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Fifty older adults in Japan (13 males and 37 females, mean age 70.8 ± 8.7 years) with 20 or more teeth were enrolled in this study. Participants were divided into Group A (26 subjects) and Group B (24 subjects) and a randomized crossover clinical trial was conducted. Intervention Study I was performed for 3 min using a prototype 16-BFE toothbrush. Dental plaque accumulation areas and gingival abrasion areas were measured before and after brushing by staining with MIRA-2-Ton. Intervention Study II was conducted in the same manner using an STF toothbrush. Crossover design was as follows: Group A was followed by an intervention study from I to II, while Group B was from II to I, with a washout period of 2 or 3 months. Analysis was performed using a modified PCR method (six sections of one tooth surface).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The average dental plaque removal rate using a 16-BFE toothbrush was 22.4%, which was a significant reduction compared to 18.5% of the STF toothbrush (<i>p</i> &lt; 0.05). There was only one small area out of 1700 areas examined regarding gingival abrasion when using a 16-BFE toothbrush.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These results suggested that the 16-BFE toothbrush provided a more effective way in dental plaque removal when compared to the STF toothbrush and was less harmful to the gingiva. Even though 16-BFE showed a significant improvement, clinical relevance and long-term effects needed to be further investigated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tooth Graft and Platelet-Rich Fibrin Mixture for Oral Bone Reconstruction and Preservation: A Scoping Review","authors":"Mina Shekarian,&nbsp;Fateme Aghajani,&nbsp;Zahra Sadat Mohajer Hejazi,&nbsp;Pedram Iranmanesh,&nbsp;Bahamin Mousa Akbari-Bezenjani,&nbsp;Abbasali Khademi","doi":"10.1002/cre2.70160","DOIUrl":"https://doi.org/10.1002/cre2.70160","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This scoping review aimed to evaluate effectiveness of using tooth graft (TG) mixture with platelet-rich fibrin (PRF), examining their roles in oral bone reconstruction and preservation, and evaluating the clinical and histopathological outcomes associated with this approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Articles were searched in Scopus, Medline, Web of Science, ProQuest, and Google Scholar up to November 2024. The search was guided by the PCC framework: Population: alveolar bone and calvaria bone defects; Concept: the use of a TG mixture with PRF as a bone graft material; Context: clinical and histopathological outcomes of oral bone reconstruction and preservation. Two independent researchers carried out the screening, study selection, and data extraction processes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Use of the PRF and TG mixture for socket preservation is superior to using each of these biomaterials individually. However, in the context of bone reconstruction, although all studies confirm new bone formation, the superiority of this mixture over the separate use of each biomaterial remains uncertain. Additionally, all studies confirm the increase in bone density and new bone formation aimed at implant placement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The majority of studies have reported that the PRF and TG mixture enhances both the quality and quantity of bone.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70160","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Endoscope-Assisted Subgingival Debridement Versus Repeated Root Surface Debridement or Access Flap Periodontal Surgery in Step 3 Periodontal Therapy: A Systematic Review and Meta-Analysis","authors":"King-Lun Dominic Ho,&nbsp;Melissa Rachel Fok,&nbsp;Kar Yan Li,&nbsp;Georgios Pelekos,&nbsp;Wai Keung Leung","doi":"10.1002/cre2.70196","DOIUrl":"https://doi.org/10.1002/cre2.70196","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Periodontitis is a multifactorial inflammatory disease leading to the progressive destruction of the tooth-supporting apparatus. The management of residual periodontal pockets remains a challenge for Step 3 periodontal therapy. This systematic review aims to evaluate the potential and efficacy of the periodontal endoscope in managing residual periodontal pockets during Step 3 periodontal therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A comprehensive search was conducted in Medline, PubMed, Cochrane Library, Embase, Scopus, and Web of Science databases up to December 2024. Studies included were randomized controlled trials (RCTs) comparing periodontal endoscope-assisted subgingival debridement (EASD) with repeated root surface debridement (RSD) and access flap periodontal surgery (AFPS). Data extraction and risk of bias assessment were performed independently by two reviewers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Five RCTs were included, involving 155 subjects and 4072 sites. EASD showed a significantly higher periodontal probing depth (PPD) reduction compared to repeated RSD, with a weighted mean difference (WMD) of 0.5 mm (95% CI: 0.19–0.81) at 3-month postoperation. At 6-month postoperation, the WMD of PPD and clinical attachment level (CAL) changes were 0.84 mm (95% CI: 0.60–1.09) and 0.89 mm (95% CI: 0.45–1.34), respectively, in favor of EASD. EASD showed a significantly higher prevalence ratio (20%) of pocket resolution (PPD ≤ 4 mm) compared to repeated RSD at 6-month postoperation. No significant differences were observed between EASD and AFPS in the changes of CAL, PPD and prevalence of pocket resolution (PPD ≤ 4 mm). The overall certainty of the evidence was deemed to be “low” for EASD versus repeated RSD comparisons and “moderate” for EASD versus AFPS comparisons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>EASD demonstrated superior clinical outcomes compared to repeated RSD in managing residual periodontal pockets. Further high-quality research is necessary to validate these findings and explore the long-term benefits of EASD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70196","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Pain After Root Canal Preparation With Different Instruments in Primary Teeth: A Systematic Review and Meta-Analysis","authors":"Kavalipurapu Venkata Teja,&nbsp;Kaligotla Apoorva Vasundhara,&nbsp;Gianrico Spagnuolo,&nbsp;Mariangela Cernera,&nbsp;Niccolò Giuseppe Armogida,&nbsp;Flavia Iaculli,&nbsp;Carlo Rengo","doi":"10.1002/cre2.70180","DOIUrl":"https://doi.org/10.1002/cre2.70180","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This systematic review and meta-analysis aimed to evaluate the effectiveness of different instrumentation systems in reducing postoperative pain following root canal preparation in primary teeth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>The present study was conducted in accordance with PRISMA guidelines and registered on PROSPERO (CRD42020135904). The review aimed to determine whether there is a difference in postoperative pain incidence using various instrumentation systems (manual and mechanical) for root canal preparation of primary teeth during pulpectomy. An extensive database search was performed using specific MeSH terms to include clinical studies up to November 2024. Based on eligibility criteria, the selected articles were subjected to quality assessment and the risk of bias was conducted using the Cochrane Risk of Bias (RoB 2) tool. In addition, meta-analyses were conducted on homogeneous studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 11 studies were included for qualitative assessments, and 7 studies underwent quantitative analysis. The results review indicated that mechanical instrumentation systems yielded better overall pain reduction compared to manual systems. The meta-analysis further demonstrated statistically significant pain reduction at 6 (<i>p</i> &lt; 0.01, 95% CI: 1.46) and 12 h (<i>p</i> &lt; 0.01, 95% CI: 2.15). However, no notable pain reduction or significance were observed at other time points (<i>p</i> = 0.41, 95% CI: 1.66; <i>p</i> = 0.23, 95% CI: 1.67; <i>p</i> = 0.61, 95% CI: 1.25). The overall risk of bias was low for the included studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Rotary NiTi instrumentation systems were superior in reducing Postoperative pain incidence in primary teeth undergoing pulpectomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Relevance</h3>\u0000 \u0000 <p>Mechanical instrumentation is not only advantageous in decreasing overall treatment time, but also in reducing pain incidence after pulpectomy, which nowadays represents an important and widely used procedure to preserve primary teeth.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study Investigating the Value of Using a Novel Mobile Application as an Adjunct to the Traditional Method of Diagnosing Periodontal Diseases","authors":"Brian Maloney,&nbsp;Bahman Honari,&nbsp;Ioannis Polyzois","doi":"10.1002/cre2.70178","DOIUrl":"https://doi.org/10.1002/cre2.70178","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Periodontal disease is a prevalent condition in the general population. An updated classification system in 2018 introduced major changes to how this disease is classified and has implications for management. Research has demonstrated challenges in reaching periodontal diagnoses with this new system, prompting the need for the development of resources to assist clinicians.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This novel research aims to determine the level of accuracy and reliability in the assignment of case definitions of periodontal diseases according to the 2018 classification using a specialized mobile application.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Newly qualified dentists were recruited and assigned five random cases to classify according to the 2018 classification system. The collected data were analyzed to determine intra- and inter-examiner accuracy and consistency.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overall accuracy of staging was 84%. The correct grade was assigned in 96% of cases. The extent was accurate in 97%. Localized disease was more reliably diagnosed than generalized forms of the condition. When accounting for stage, grade, and extent, examiners demonstrated 76% accuracy. Inter-examiner agreement was 62.5%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>There was a high level of diagnostic accuracy and consistency in periodontal disease diagnosis when diagnostic software was used as an adjunct to assigning case definitions. Dedicated software like “PerioBrain” has the potential to improve diagnostic accuracy. Further research is warranted to investigate the use of this application in a clinical setting and for didactic teaching of a student cohort.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}