{"title":"RANKL， OPG和CTS-K释放在骨整合建立过程中对下颌磨牙部位单种植体即刻无功能负荷的骨反应","authors":"Xiaowen Hu, Yijie Fan, Xuexia Chen","doi":"10.1002/cre2.70193","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>To verify that osseointegration maturation under immediate restoration is correlative with active release of cytokines.</p>\n </section>\n \n <section>\n \n <h3> Material and Methods</h3>\n \n <p>The participants needing the restoration of a single missing mandibular molar were randomized into immediate restoration (IR) and conventional restoration group (CR). All eligible patients were recalled for collecting peri-implant crevicular fluid (PICF) samples according to the scheduled follow-up time point during osseointegration and functional loading. Detection of receptor activator of nuclear factor-KB ligand, osteoprotegerin, and cathepsin K in PICF was conducted to statistically analyze their difference between IR and CR groups.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>During the osseointegration period, the overall level of these cytokines in the IR group was statistically higher than that of the corresponding cytokine in the CR group. During functional loading, the overall level of the each cytokine in CR was statistically different from that of the corresponding cytokine during osseointegration, but the overall level of each cytokine was not statistically different between the two groups.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The rapid osseointegration maturation under immediate restoration is probably correlative with active release of cytokines related with bone metabolism.</p>\n </section>\n </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70193","citationCount":"0","resultStr":"{\"title\":\"RANKL, OPG, and CTS-K Release in Bone Response to Immediate Nonfunctional Loading of a Single Implant in Mandibular Molar Sites During Osseointegration Establishment\",\"authors\":\"Xiaowen Hu, Yijie Fan, Xuexia Chen\",\"doi\":\"10.1002/cre2.70193\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>To verify that osseointegration maturation under immediate restoration is correlative with active release of cytokines.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Material and Methods</h3>\\n \\n <p>The participants needing the restoration of a single missing mandibular molar were randomized into immediate restoration (IR) and conventional restoration group (CR). All eligible patients were recalled for collecting peri-implant crevicular fluid (PICF) samples according to the scheduled follow-up time point during osseointegration and functional loading. Detection of receptor activator of nuclear factor-KB ligand, osteoprotegerin, and cathepsin K in PICF was conducted to statistically analyze their difference between IR and CR groups.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>During the osseointegration period, the overall level of these cytokines in the IR group was statistically higher than that of the corresponding cytokine in the CR group. During functional loading, the overall level of the each cytokine in CR was statistically different from that of the corresponding cytokine during osseointegration, but the overall level of each cytokine was not statistically different between the two groups.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>The rapid osseointegration maturation under immediate restoration is probably correlative with active release of cytokines related with bone metabolism.</p>\\n </section>\\n </div>\",\"PeriodicalId\":10203,\"journal\":{\"name\":\"Clinical and Experimental Dental Research\",\"volume\":\"11 4\",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70193\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Experimental Dental Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cre2.70193\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Dental Research","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cre2.70193","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
RANKL, OPG, and CTS-K Release in Bone Response to Immediate Nonfunctional Loading of a Single Implant in Mandibular Molar Sites During Osseointegration Establishment
Objectives
To verify that osseointegration maturation under immediate restoration is correlative with active release of cytokines.
Material and Methods
The participants needing the restoration of a single missing mandibular molar were randomized into immediate restoration (IR) and conventional restoration group (CR). All eligible patients were recalled for collecting peri-implant crevicular fluid (PICF) samples according to the scheduled follow-up time point during osseointegration and functional loading. Detection of receptor activator of nuclear factor-KB ligand, osteoprotegerin, and cathepsin K in PICF was conducted to statistically analyze their difference between IR and CR groups.
Results
During the osseointegration period, the overall level of these cytokines in the IR group was statistically higher than that of the corresponding cytokine in the CR group. During functional loading, the overall level of the each cytokine in CR was statistically different from that of the corresponding cytokine during osseointegration, but the overall level of each cytokine was not statistically different between the two groups.
Conclusions
The rapid osseointegration maturation under immediate restoration is probably correlative with active release of cytokines related with bone metabolism.
期刊介绍：
Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.
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