Clinical and Experimental Dental Research最新文献

{"title":"Effects of the Presence of Adjacent Tooth and Material Type on the Marginal and Internal Adaptation of Endocrowns Fabricated by the Digital Impression Technique","authors":"Mehran Falahchai,&nbsp;Fatemeh Razavi Ardekani,&nbsp;Naghme Musapoor,&nbsp;Yasamin Babaee Hemmati,&nbsp;Hamid Neshandar Asli","doi":"10.1002/cre2.70077","DOIUrl":"https://doi.org/10.1002/cre2.70077","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To assess the effects of the presence of adjacent tooth and material type on the marginal and internal adaptation of endocrowns fabricated by the digital impression technique.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>An endodontically treated molar tooth was used for the fabrication of endocrowns in this in vitro study. Five groups of specimens (<i>n</i> = 17) were evaluated based on the material type and presence of adjacent tooth: three groups of monolithic zirconia (Zir), lithium disilicate (LDS), and zirconia-reinforced lithium silicate (ZLS) in the presence of adjacent teeth, and two groups of zirconia endocrowns, one in the absence of an adjacent anterior tooth (second premolar; Zir-no ant.) and one in the absence of a posterior adjacent tooth (second molar; Zir-no post.). Marginal and internal adaptation of endocrowns was evaluated by the silicone replica technique. Data were analyzed by ANOVA with Tukey test for pairwise comparisons and generalized estimating equation with Bonferroni correction for pairwise comparisons (α = 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The largest marginal gap was found in the ZLS, followed by the LDS and Zir groups (<i>p</i> &lt; 0.05). The Zir group showed significantly higher internal adaptation than the ZLS group (<i>p</i> &lt; 0.05); LDS had no significant difference with the ZLS and Zir groups (<i>p</i> &gt; 0.05). The Zir group showed larger marginal and internal gaps than the Zir-no ant. and Zir-no post. groups (<i>p</i> &lt; 0.05); the latter two groups had no significant difference (<i>p</i> &gt; 0.05). All groups showed the largest gap at the pulpal and the smallest gap at the marginal and cervical areas (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Zirconia endocrowns showed the highest marginal and internal adaptation. Digital impression technique in absence of anterior or posterior adjacent tooth would result in higher marginal and internal adaptation of endocrowns.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Electrical Heat Carrier Temperature on Bacterial Leakage of Endodontically Treated Teeth Using a Bioceramic Sealer","authors":"Mir Ahmad Nabavi,&nbsp;Mahmood Reza Kalantar Motamedi,&nbsp;Pedram Fattahi,&nbsp;Saber Khazaei","doi":"10.1002/cre2.70059","DOIUrl":"10.1002/cre2.70059","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of this study is to investigate the effect of electrical heat carrier temperature on bacterial leakage of root canals obturated with the continuous wave of condensation (CWC) technique and a bioceramic sealer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This ex vivo experimental study was conducted on 92 extracted single-rooted teeth. The teeth were subjected to endodontic treatment and obturated with the Endoseal MTA bioceramic sealer by the CWC technique using two different temperature settings of the electrical heat carrier: 120°C (group G120, <i>n</i> = 41) and 200°C (group G200, <i>n</i> = 41). A positive and a negative control group were also considered (<i>n</i> = 5 each). Bacterial leakage was assessed over a 40-day period using a bacterial leakage model. The incidence of bacterial leakage was compared between the experimental groups using the log-rank test. The significance level was set at 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median survival rate was 39.0 (25.0) days in the G120 group and 34.0 (25.0) days in the G200 group. Despite a slightly higher survival rate in the G120 group, the difference between the two experimental groups was not statistically significant (<i>p</i> = 0.612).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The tested temperatures of the electrical heat carrier (120°C and 200°C) did not have a significant effect on bacterial leakage of root canals obturated by the CWC technique and the Endoseal MTA bioceramic sealer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Expression of Hard Tissue Proteins in Hypomineralized Second Primary Molars in Comparison to Normal Teeth","authors":"Sharon Jessica,&nbsp;Ramya Sekar,&nbsp;Snehashish Ghosh,&nbsp;Safal Dhungel,&nbsp;Kavitha B.,&nbsp;Mahesh Ramakrishnan,&nbsp;Shazia Fathima Jh,&nbsp;Monisha Prasad,&nbsp;Jaiganesh I.,&nbsp;Sindhu Subramani","doi":"10.1002/cre2.70079","DOIUrl":"10.1002/cre2.70079","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to identify the proteins in hypomineralized second primary molars (HSPMs) and correlate their function in Amelogenesis. HSPM is a qualitative defect of the enamel of the second primary molars with no clear etiology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Total protein quantification was performed using the Bradford Protein Assay, followed by the electrophoretic separation of samples using 2D-Gel electrophoresis to identify the proteins.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results from the Bradford Protein Assay unveiled a five-fold increase in the protein content in HSPM. Proteins such as Dentin sialo-phosphoprotein (DSPP), Keratin, type I, Serum Albumin, Anti-thrombin III, Alpha-1-Antitrypsin, Histone H3.2, Actin, Heat shock Protein, Vimentin, Desmoglein-3, Glyceraldehyde-3-phosphate dehydrogenase, Inosine-5'-monophosphate dehydrogenase 2, Zinc Alpha 2 glycoprotein, Lysozyme C, Prothrombin, Vit-D binding Protein, Apolipoprotein A-1, Defensin 1, Immunoglobulin Gamma, Immunoglobulin Kappa, and Alpha-Amylase were all upregulated (<i>p</i> &lt; 0.05) in HSPM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This investigation conclusively demonstrates that HSPM-affected teeth have higher protein content than healthy teeth. The study also supports the theory of proteolytic inhibition attributed to reduced protease activity and heightened protease inhibitor activity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Choice of Flavor of Fluoride Varnish on Behavior in Dental Visits in Schoolchildren","authors":"R. Karim,&nbsp;C. H. Splieth,&nbsp;J. Schmoeckel","doi":"10.1002/cre2.70069","DOIUrl":"10.1002/cre2.70069","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the effect of choosing the taste of a fluoride varnish on the behavior and acceptance of the children during the dental visit.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>This single-blinded, randomized controlled trial (NCT05285228) involved 70 healthy children aged 5–10 years who presented for a dental recall visit including the indication of an application of fluoride varnish to the specialized pediatric university dental service. The control group received the fluoride varnish (Profluorid varnish, VOCO Germany) with an allocated taste, whereas the test group had to choose the taste of the fluoride varnish just before the dental check-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The vast majority of the children (<i>n</i> = 53, 75.7%) felt <i>happy/very happy</i> (Facial image scale) regarding the taste of the fluoride varnish, with no significant difference between both groups (<i>p</i> = 0.188). Dental behavior (Frankl behavior rating scale) was assessed generally as <i>positive/definitely positive</i> (<i>n</i> = 58, 82.2%). Interestingly, children with a history of previous negative dental behavior in the test group showed a tendency of more positive behavior than in the control group (66.6% vs. 33.4%, <i>p</i> = 0.244).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Sense of control performed via choosing the flavor of the fluoride varnish increases the chance for positive behavior during the dental visit, especially in children with a history of negative dental behavior. Concurrently, it improves the child's taste acceptance, which is important for dental caries prevention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>The study protocol was registered on Cli ClinicalTrials.gov (NCT05285228).</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Force Degradation of Intermaxillary Latex Elastics: Comparative In Vitro and In Vivo Study","authors":"Lucie Ptáčková,&nbsp;Barbora Ličková,&nbsp;Wanda Urbanová,&nbsp;David Sluka,&nbsp;Klaudia Portašíková,&nbsp;Soňa Chamlarová,&nbsp;Iva Voborná,&nbsp;Ivana Dubovská","doi":"10.1002/cre2.70072","DOIUrl":"10.1002/cre2.70072","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to compare the force degradation of intermaxillary elastics (IE) in vitro and in vivo while stretching the IE to a precise diameter.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>IE 3/16″ medium Dentaurum from five different batches of packaging were analyzed. The in vivo study involved 10 volunteers, of which 100 IE were examined. To achieve three times the original diameter of the elastic, the distance between the upper canine and the lower dental arch was measured. Buttons were then placed in the mouth accordingly, and IE and passive aligners were inserted for five sessions of 48 h each. To investigate in vitro, 100 IE were placed in an incubator set at 37°C in a humid environment and stretched three times their diameter. The force of the elastics was measured in both investigations using a force meter at 0, 2, 8, 24, and 48 h.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In all patients except one, the three times diameter distance extended from the upper canine to the lower second premolar. The force degradation in vivo at 2, 8, 24, and 48 h was 20.58%, 26.78%, 34.81%, and 38.56% and in vitro was 16.38%, 22.83%, 28.32%, and 30.78%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The amount of stretching of IE varies for each patient when using standard insertion points. The force of IE decreases exponentially, the force degradation in vivo being higher. The clinician must consider the force decrease when advising the patient of the time interval to change the elastics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Multimodality Treatment Including Stabilization Splint and Low-Level Laser Therapies on Managing Temporomandibular Disorders: A Pilot Randomized Controlled Trial","authors":"Zahra Afshari,&nbsp;Nazieh Abdollah Kookhi,&nbsp;Mahdi Shamali,&nbsp;Majid Sedaghat Monfared,&nbsp;Sara Tavakolizadeh","doi":"10.1002/cre2.70038","DOIUrl":"10.1002/cre2.70038","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Temporomandibular disorder (TMD) encompasses various clinical issues affecting the temporomandibular joint, masticatory muscles, and surrounding structures. Common symptoms include pain, joint and muscle tenderness, and limited jaw movement. Diverse treatment options have been utilized to manage TMD. However, evidence of the combined modality treatment approach is scarce. This pilot trial aimed to evaluate the effectiveness of combining stabilization splint therapy (SST) with low-level laser therapy (LLLT) in managing TMD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>This pilot parallel randomized clinical trial included 30 patients with TMD. Patients were randomly allocated equally into three treatment groups: SST, LLLT, and combined treatment (CT). Outcomes, including pain and functional limitations, were measured at baseline, 1, 2, 3, and 4 weeks after the start of each treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>CT was significantly more effective in reducing pain in patients with TMD compared to LLLT and SST. Although patients in the LLLT group reported significantly reduced pain, they still had higher pain scores compared to the SST group at certain time points, indicating that LLLT was not as effective as SST. Most functional limitations were improved over time, more consistently within the CT group, but without significant differences between the three groups. Patients were more satisfied with CT compared to LLLT and SST.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The superior results of the CT group over the SST and LLLT groups were evident in this pilot trial's outcomes. The combined modality treatment approach seems to yield the greatest improvement for TMD patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Correlation Between Langerhans Cells Population and Prognosis of Tongue Squamous Cell Carcinoma","authors":"Narges Ghazi,&nbsp;Nasrollah Saghravanian,&nbsp;Pooya Saeedi,&nbsp;Mohammad Mahdi Maboudinezhad","doi":"10.1002/cre2.70080","DOIUrl":"10.1002/cre2.70080","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Objective</h3>\u0000 \u0000 <p>Tongue squamous cell carcinoma (TSCC) is the most prevalent oral cancer. Despite considerable advancements in treatment, the 5-year survival rate remains relatively unchanged. Langerhans cells (LCs) play an important role in antitumor immunity. Therefore, we attempt to evaluate the correlation between the LC count and disease prognosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Histopathologic slides from 24 cases, with at least 2 years of follow-up, were selected and categorized into early-stage (12 cases) and advanced-stage (12 cases) groups. An additional 12 slides of normal tissue comprised the control group. Immunohistochemical staining with the CD1a marker was performed to analyze the density of LCs. Statistical analysis assessed the impact of CD1a immune expression on patient survival and other variables such as age, gender, stage, and histopathological grade.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Comparison of CD1a+ cell counts across the three groups revealed a significant decrease in the advanced group. Furthermore, a lower count of CD1a+ cells correlated with poorer disease-free survival (DFS) (<i>p</i> &lt; 0.001) and overall survival (OS) (<i>p</i> = 0.049). Although the CD1a+ cell count did not independently affect OS significantly (<i>p</i> = 0.210), it did show a significant impact on DFS as an independent variable (<i>p</i> = 0.002).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The significant correlation between CD1a expression and patients' prognosis and survival rates suggests that CD1a+ cells could serve as a crucial prognostic factor in the management and treatment of TSCC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marginal Fit and Fracture Resistance of Vertical Versus Horizontal Margins in Monolithic Zirconia Crowns","authors":"Mohamed A. Salama,&nbsp;Mohamed F. Aldamaty,&nbsp;Moamen A. Abdalla,&nbsp;Elsayed Ali Omar,&nbsp;Mohammed H. AbdElaziz,&nbsp;Ahmed Yaseen Alqutaibi","doi":"10.1002/cre2.70064","DOIUrl":"10.1002/cre2.70064","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The use of vertical margin design in all-ceramic restoration has generated inquiries regarding its clinical efficacy under diverse dynamic oral conditions. This research aims to assess the marginal fit and fracture resistance of monolithic zirconia crowns featuring vertical margin design as opposed to those with conventional horizontal margin design.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Two metal dies were employed to generate replicated resin dies mimicking mandibular first molar preparation. The metal dies were precision-engineered with two margin designs: vertical margin design presenting a shoulderless configuration (Featheredge) and horizontal margin design (Radial Shoulder). Forty zirconia crowns were produced on the replicated resin dies using two varieties of monolithic zirconia, with twenty crowns in each category: pre-shaded and multilayered zirconia. Both sets were further subdivided into two groups based on the finish line configuration utilized (n = 10). The vertical marginal gap of the zirconia crowns was gauged before and after thermocycling (5-55oC/5000 cycles), followed by loading the crowns until fracture occurred. Statistical analysis was performed using one-way analysis of variance (ANOVA), accompanied by Bonferroni's post hoc test and independent <i>t</i>-test for pairwise comparisons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The Shoulder subgroup of BruxZir exhibited the highest mean marginal gap value (120.06 ± 10.15 µ), while the Featheredge subgroup of BruxZir displayed the lowest value (49.72 ± 6.53 µ). Among the BruxZir group, the Featheredge subgroup showcased the highest mean fracture resistance value (4251.57 ± 279.90 N), whereas the Shoulder subgroup recorded the lowest value (1721.60 ± 225.16 N).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Monolithic zirconia crowns with vertical margin design (Featheredge) demonstrated statistically enhanced performance compared to conventional horizontal margin design, as evidenced by lower marginal gap values and increased fracture resistance tolerance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Evaluation of the Antibacterial Properties of an Experimental Herbal Gel Against Cariogenic Bacteria","authors":"Marco Sánchez-Tito,&nbsp;Lidia Yileng Tay,&nbsp;Francisco Zea-Gamboa,&nbsp;Raúl Cartagena-Cutipa,&nbsp;Alysson Flores-Gómez,&nbsp;Bruno Spigno-Paco,&nbsp;Brando Raul Mendoza Salinas,&nbsp;Jose Elias Zuñiga Calcina,&nbsp;Ingrit Elida Collantes Díaz","doi":"10.1002/cre2.70076","DOIUrl":"10.1002/cre2.70076","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Recently, products with antibacterial properties derived from medicinal plants have increased as an alternative to conventional drugs. Thus, this study aimed to formulate and evaluate the antibacterial activity of an experimental gel based on <i>Grindelia tarapacana</i> essential oil in a bacterial consortium.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>The composition of the essential oil (EO) was determined using gas chromatography-mass spectrometry (GC-MS). The antibacterial activity of the EO against <i>Streptococcus mutans</i> ATCC 25175, <i>Streptococcus sanguinis</i> ATCC 10556, and <i>Streptococcus salivarius</i> ATCC 13419 was evaluated using an Agar disc diffusion and minimum inhibitory concentration methods. Five formulations of the experimental gel were prepared at 0.25%, 0.5%, 1%, 1.5%, and 2% (v/v). The antibacterial susceptibility test was evaluated using an Agar-Well diffusion assay against a bacterial consortium of <i>S. mutans</i>, <i>S. sanguinis</i>, and <i>S. salivarius</i>. The physical properties, pH, spreadability, gel morphology, phase separation, and drug release were evaluated. The experimental gels were compared with a chlorhexidine gel. Data were analyzed with one-way ANOVA and Kruskal–Wallis tests with a significant level of 5%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The major components of the EO were bornyl acetate, α-isomethyl-<i>E</i>-nerolidol, germacrene B, <i>E</i>-nerolidol, α-cedrene-epoxide, fokienol, and 10-epi-γ-eudesmol. All formulations were effective in inhibiting bacterial growth. The 2% concentration presented inhibition zones (18.14 ± 1.01 mm) similar to those observed for the chlorhexidine gel (<i>p</i> &gt; 0.05). All formulations were stable, without signs of separation, with adequate physical properties, and no significant differences were observed regarding the drug content with the chlorhexidine gel (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The experimental gels based on <i>G. tarapacana</i> EO presented good physicochemical properties and were highly effective in inhibiting the growth of a cariogenic bacterial consortium.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Occlusal Scheme and Bone-Level Implant Number and Position on Stress Distribution in Kennedy Class II Implant-Assisted Removable Partial Dentures: A 3D Finite Element Analysis","authors":"Solmaz Barati,&nbsp;Safoura Ghodsi,&nbsp;Somayeh Zeighami","doi":"10.1002/cre2.70078","DOIUrl":"10.1002/cre2.70078","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To assess the effect of occlusion and implant number/position on stress distribution in Kennedy Class II implant-assisted removable partial denture (IARPD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>IARPDs were designed in six models: with one implant (bone level with a platform of 4 mm and length of 10 mm) at the site of (I) canine, (II) between first and second premolars, (III) first molar, (IV) second molar, or two implants at the sites of (V) canine-first molar, and (VI) canine-second molar. A conventional RPD served as control. Loads were applied according to the group function (GF) (500N load was applied to the left canine/premolar/molar teeth in the ratio of 1:1:2) or canine guidance (CG) (125N load was to the canine tooth) occlusions. Maximum displacement and Von Mises Stress in different components were analyzed by finite element analysis (FEA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The control model showed the highest displacement followed by the IARPD with a canine implant in both occlusal schemes. In GF, the maximum and minimum jaw stress were recorded in IARPDs with canine implants (16.45 MPa) and canine-first molar implants (13.47 MPa), respectively. In CG, the maximum and minimum jaw stress was recorded in IARPD with first/second premolar implant (15.91 MPa) and canine-first molar implants (12.38 MPa), respectively. The highest stress in resin, framework, and implant(s) was noted in IARPD with canine implant in both schemes. The lowest stress in the implant(s) was recorded in IARPD with canine-second molar implants in GP and IARPD with canine-first molar implants in CG.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Dental implants reduced the total displacement of IARPDs, increased stress in mechanical components, and did not affect stress distribution in biological components. Insertion of two implants decreased implant stress. The GP scheme caused greater stress on mechanical components.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11746924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}