Shabnam Ajami, Seyyed Hadi Hosseini, Neda Babanouri, Zahra Hashemi
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The degree of pain and discomfort was measured using a visual analog scale (VAS) at the following time points: Immediately after the separator placement (T<sub>0</sub>), 2 h posttreatment (T<sub>1</sub>), 6 h posttreatment (T<sub>2</sub>), 24 h posttreatment (T<sub>3</sub>), and 48 h after separator placement (T<sub>4</sub>). The data were analyzed using SPSS (version 15.0). Different statistical tests including ANOVA, Tukey's test, and paired <i>t</i>-test were utilized. <i>p</i> < 0.05 was considered statistically significant.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Pain scores at 2 h (T1) and 6 h (T2) after separator placement differed significantly among the three groups (<i>p</i> = 0.006 and <i>p</i> = 0.025, respectively), with the Ibuprofen group experiencing significantly higher pain levels than the Bromelain and Bromelain Plus Turmeric groups. At 48 h (T4), a significant difference was observed only in chewing function (<i>p</i> = 0.024), where patients in the Bromelain group reported higher pain scores than those in the Ibuprofen group. Sex had no significant effect on pain perception (<i>P</i> < <i>0.05</i>).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Bromelain with or without turmeric might be a useful alternative to Ibuprofen for pain control following orthodontic separator placement.</p>\n </section>\n </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 2","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70124","citationCount":"0","resultStr":"{\"title\":\"Analgesic Efficacy of Bromelain and Bromelain Plus Turmeric for Pain Control After Orthodontic Separator Placement: A Triple-Blind Randomized Clinical Trial\",\"authors\":\"Shabnam Ajami, Seyyed Hadi Hosseini, Neda Babanouri, Zahra Hashemi\",\"doi\":\"10.1002/cre2.70124\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>This study aimed to compare the analgesic efficacy of Bromelain, Ibuprofen, and Bromelain plus turmeric for pain control after orthodontic separator placement.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Material and Methods</h3>\\n \\n <p>This triple-blind randomized clinical trial included 135 patients over the age of 15 who required orthodontic treatment. The patients were randomly assigned to three groups: 400 mg Ibuprofen (Group A), 200 mg Bromelain (ANAHEAL; Group B), and 150 mg Bromelain + 300 mg Turmeric (ANAHEAL PLUS; Group C). The patients took one tablet immediately after the separator was placed. Four separators were placed at the mesial and distal regions of both maxillary first molars. The degree of pain and discomfort was measured using a visual analog scale (VAS) at the following time points: Immediately after the separator placement (T<sub>0</sub>), 2 h posttreatment (T<sub>1</sub>), 6 h posttreatment (T<sub>2</sub>), 24 h posttreatment (T<sub>3</sub>), and 48 h after separator placement (T<sub>4</sub>). The data were analyzed using SPSS (version 15.0). 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引用次数: 0
摘要
目的比较菠萝蛋白酶、布洛芬、菠萝蛋白酶加姜黄对正畸隔离器放置后疼痛控制的镇痛效果。材料与方法本三盲随机临床试验纳入135例15岁以上需要正畸治疗的患者。患者被随机分为三组：400 mg布洛芬（A组），200 mg菠萝蛋白酶(ANAHEAL；B组)和150毫克菠萝蛋白酶+ 300毫克姜黄(ANAHEAL PLUS；C组)。隔离剂放置后立即服用1片。在上颌第一磨牙的中、远端分别放置4个分离器。采用视觉模拟量表（VAS）在以下时间点测量疼痛和不适程度：隔离器放置后立即（T0）、治疗后2小时（T1）、治疗后6小时（T2）、治疗后24小时（T3）和放置隔离器后48小时（T4）。数据采用SPSS（15.0版）分析。采用方差分析、Tukey检验、配对t检验等统计检验。P <； 0.05认为有统计学意义。结果三组患者在放置分离器后2 h （T1）和6 h （T2）疼痛评分差异有统计学意义（p = 0.006和p = 0.025），其中布洛芬组疼痛水平明显高于菠萝蛋白酶组和菠萝蛋白酶加姜黄组。在48 h （T4）时，仅在咀嚼功能上观察到显著差异（p = 0.024），其中菠萝蛋白酶组患者报告的疼痛评分高于布洛芬组。性别对疼痛感知无显著影响（P < 0.05）。结论菠萝蛋白酶加姜黄或不加姜黄可作为布洛芬的有效替代，用于正畸隔离器放置后的疼痛控制。
Analgesic Efficacy of Bromelain and Bromelain Plus Turmeric for Pain Control After Orthodontic Separator Placement: A Triple-Blind Randomized Clinical Trial
Objectives
This study aimed to compare the analgesic efficacy of Bromelain, Ibuprofen, and Bromelain plus turmeric for pain control after orthodontic separator placement.
Material and Methods
This triple-blind randomized clinical trial included 135 patients over the age of 15 who required orthodontic treatment. The patients were randomly assigned to three groups: 400 mg Ibuprofen (Group A), 200 mg Bromelain (ANAHEAL; Group B), and 150 mg Bromelain + 300 mg Turmeric (ANAHEAL PLUS; Group C). The patients took one tablet immediately after the separator was placed. Four separators were placed at the mesial and distal regions of both maxillary first molars. The degree of pain and discomfort was measured using a visual analog scale (VAS) at the following time points: Immediately after the separator placement (T0), 2 h posttreatment (T1), 6 h posttreatment (T2), 24 h posttreatment (T3), and 48 h after separator placement (T4). The data were analyzed using SPSS (version 15.0). Different statistical tests including ANOVA, Tukey's test, and paired t-test were utilized. p < 0.05 was considered statistically significant.
Results
Pain scores at 2 h (T1) and 6 h (T2) after separator placement differed significantly among the three groups (p = 0.006 and p = 0.025, respectively), with the Ibuprofen group experiencing significantly higher pain levels than the Bromelain and Bromelain Plus Turmeric groups. At 48 h (T4), a significant difference was observed only in chewing function (p = 0.024), where patients in the Bromelain group reported higher pain scores than those in the Ibuprofen group. Sex had no significant effect on pain perception (P < 0.05).
Conclusions
Bromelain with or without turmeric might be a useful alternative to Ibuprofen for pain control following orthodontic separator placement.
期刊介绍：
Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.
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