RANKL, OPG, and CTS-K Release in Bone Response to Immediate Nonfunctional Loading of a Single Implant in Mandibular Molar Sites During Osseointegration Establishment

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research Pub Date : 2025-08-12 DOI:10.1002/cre2.70193

Xiaowen Hu, Yijie Fan, Xuexia Chen

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引用次数: 0

Abstract

Objectives

To verify that osseointegration maturation under immediate restoration is correlative with active release of cytokines.

Material and Methods

The participants needing the restoration of a single missing mandibular molar were randomized into immediate restoration (IR) and conventional restoration group (CR). All eligible patients were recalled for collecting peri-implant crevicular fluid (PICF) samples according to the scheduled follow-up time point during osseointegration and functional loading. Detection of receptor activator of nuclear factor-KB ligand, osteoprotegerin, and cathepsin K in PICF was conducted to statistically analyze their difference between IR and CR groups.

Results

During the osseointegration period, the overall level of these cytokines in the IR group was statistically higher than that of the corresponding cytokine in the CR group. During functional loading, the overall level of the each cytokine in CR was statistically different from that of the corresponding cytokine during osseointegration, but the overall level of each cytokine was not statistically different between the two groups.

Conclusions

The rapid osseointegration maturation under immediate restoration is probably correlative with active release of cytokines related with bone metabolism.

Abstract Image

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RANKL， OPG和CTS-K释放在骨整合建立过程中对下颌磨牙部位单种植体即刻无功能负荷的骨反应

目的验证即刻修复下骨整合成熟与细胞因子的活性释放相关。材料与方法将需要修复单颗缺失下颌磨牙的受试者随机分为立即修复组（IR）和常规修复组（CR）。所有符合条件的患者在骨整合和功能负荷期间根据预定的随访时间点被召回收集种植体周围沟液（PICF）样本。检测PICF中核因子- kb配体受体激活剂、骨保护素、组织蛋白酶K，统计分析IR组与CR组间差异。结果在骨整合期间，IR组这些细胞因子的总体水平均高于CR组。功能负荷时CR中各细胞因子的总体水平与骨整合时相应细胞因子的总体水平有统计学差异，但两组间各细胞因子的总体水平无统计学差异。结论即刻修复下骨整合的快速成熟可能与骨代谢相关细胞因子的活性释放有关。

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来源期刊

Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.60%

发文量

165

审稿时长

26 weeks

期刊介绍： Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.