IF 3.4 2区心理学

Emotion Pub Date : 2025-08-01 Epub Date: 2025-01-30 DOI: 10.1037/emo0001489

Gregory John Depow, Victoria Oldemburgo de Mello, Michael Inzlicht

{"title":"A positive empathy intervention to improve well-being on Instagram.","authors":"Gregory John Depow, Victoria Oldemburgo de Mello, Michael Inzlicht","doi":"10.1037/emo0001489","DOIUrl":"10.1037/emo0001489","url":null,"abstract":"With more than half the global population on social media, there is a critical need to understand how to engage it in a way that improves rather than worsens user well-being. Here, we show that positive empathy is a promising tool. Participants who received brief positive empathy instructions before 10 min of browsing their own Instagram feed showed greater affective well-being (Studies 1-4) and life satisfaction (Study 4) at posttest relative to participants who were instructed to browse as usual. The positive empathy intervention showed an average effect size on well-being of about a quarter of a standard deviation (mean Cohen's d = 0.25). We included unique active control groups in each study. We found using positive empathy on social media was about as beneficial to well-being as watching a nature video (Study 1, N = 298) and was better than instructions to focus on positive content (Study 2, N = 302), empathize with all emotions (Study 3, N = 301), or reappraise one's own emotions (Study 4, N = 426). We used structural equation modeling to demonstrate the effect of the intervention on subjective well-being is mediated by changes in positive emotion sharing, appreciative joy, and self-compassion. These experiences form a latent factor we term positive empathy. Our results show that a brief intervention successfully manipulates positive empathy on Instagram, which increases well-being. (PsycInfo Database Record (c) 2025 APA, all rights reserved).","PeriodicalId":48417,"journal":{"name":"Emotion","volume":" ","pages":"1207-1224"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene-environment interplay linking friends' antisociality with different developmental trajectories of antisocial behavior during adolescence. 青少年反社会行为发展轨迹与朋友反社会行为的基因-环境相互作用。

IF 3.1 2区心理学

Developmental Psychology Pub Date : 2025-08-01 Epub Date: 2025-04-28 DOI: 10.1037/dev0001970

Mara Brendgen, Frank Vitaro, Yao Zheng, Alain Girard, Ginette Dionne, Michel Boivin

{"title":"Gene-environment interplay linking friends' antisociality with different developmental trajectories of antisocial behavior during adolescence.","authors":"Mara Brendgen, Frank Vitaro, Yao Zheng, Alain Girard, Ginette Dionne, Michel Boivin","doi":"10.1037/dev0001970","DOIUrl":"10.1037/dev0001970","url":null,"abstract":"This study investigated gene-environment correlations and interactions underlying the association between distinct developmental trajectories of adolescents' antisocial behavior and their friends' antisociality. Participants were 398 twin pairs (53% girls; 87% European descent) followed from age 13 to 19 years. Self-reported antisocial behavior was obtained from the twins and from their friends. Latent class growth modeling identified three antisocial behavior trajectories: nonantisocial, stable-low, and persistent-high. Biometric modeling revealed significant genetic influence on the probabilities of following either the nonantisocial or the persistent-high antisocial behavior trajectory. In contrast, the probability of following the stable-low trajectory was almost entirely explained by environmental influences. All three trajectories were correlated with friends' antisociality and these correlations were entirely explained by shared underlying environmental-not genetic-pathways. Moreover, friends' antisociality moderated the relative influence of genetic factors on the probability of following the persistent-high trajectory, as well as the relative influence of environmental factors on the probability of following the stable-low trajectory. The discussion stresses the importance of distinguishing distinct developmental trajectories of antisocial behavior during adolescence and the differential moderating role played by friends' antisociality. (PsycInfo Database Record (c) 2025 APA, all rights reserved).","PeriodicalId":48464,"journal":{"name":"Developmental Psychology","volume":" ","pages":"1578-1593"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Childhood language development and alexithymia in adolescence: an 8-year longitudinal study. 儿童时期的语言发展与青春期的亚历山大症：一项为期 8 年的纵向研究。

IF 3.1 2区心理学

Development and Psychopathology Pub Date : 2025-08-01 Epub Date: 2024-10-04 DOI: 10.1017/S0954579424001007

Ka Shu Lee, Caroline Catmur, Geoffrey Bird

{"title":"Childhood language development and alexithymia in adolescence: an 8-year longitudinal study.","authors":"Ka Shu Lee, Caroline Catmur, Geoffrey Bird","doi":"10.1017/S0954579424001007","DOIUrl":"10.1017/S0954579424001007","url":null,"abstract":"Alexithymia (difficulties identifying and describing feelings) predicts increased risks for psychopathology, especially during the transition from childhood to adolescence. However, little is known of the early contributors to alexithymia. The language hypothesis of alexithymia suggests that language deficits play a primary role in predisposing language-impaired groups to developing alexithymia; yet longitudinal data tracking prospective relationship between language function and alexithymia are scarce. Leveraging data from the Surrey Communication and Language in Education cohort (N = 229, mean age at time point 1 = 5.32 years, SD = 0.29, 51.1% female), we investigated the prospective link between childhood language development and alexithymic traits in adolescence. Results indicated that boys with low language function at ages 4-5 years, and those who later met the diagnostic criteria for language disorders at ages 5-6 years, reported elevated alexithymic traits when they reached adolescence. Parent-reported child syntax abilities at ages 5-6 years revealed a dimensional relationship with alexithymic traits, and this was consistent with behavioral assessments on related structural language abilities. Empirically derived language groups and latent language trajectories did not predict alexithymic traits in adolescence. While findings support the language hypothesis of alexithymia, greater specificity of the alexithymia construct in developmental populations is needed to guide clinical interventions.","PeriodicalId":11265,"journal":{"name":"Development and Psychopathology","volume":" ","pages":"1165-1175"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profiles of self-regulation and their association with behavior problems among sexually abused children. 性虐待儿童的自我调节能力及其与行为问题的关系。

IF 3.1 2区心理学

Development and Psychopathology Pub Date : 2025-08-01 Epub Date: 2024-10-04 DOI: 10.1017/S0954579424001196

Laetitia Mélissande Amédée, Chantal Cyr, Martine Hébert

{"title":"Profiles of self-regulation and their association with behavior problems among sexually abused children.","authors":"Laetitia Mélissande Amédée, Chantal Cyr, Martine Hébert","doi":"10.1017/S0954579424001196","DOIUrl":"10.1017/S0954579424001196","url":null,"abstract":"This study aimed to delineate profiles of self-regulation among sexually abused children and their association with behavior problems using a person-centered approach. A sample of 223 children aged six to 12, their parents, and teachers were recruited in specialized intervention centers. Latent profile analysis revealed four profiles: (1) Dysregulated, (2) Inhibited, (3) Flexibly Regulated, and (4) Parent Perceived Self-Regulation. Children from the Flexibly Regulated profile showed relatively low behavior problems, and those from the Dysregulated profile were characterized by high behavior problems. Children from the Parent Perceived Self-Regulation profile showed overall good adaptation, although teachers reported higher behavior problems than parents. Children from the Inhibited profile, characterized by the highest level of inhibition but low parent-rated emotion regulation competencies and executive functions, showed the highest level of internalizing behavior problems, indicating that high inhibition does not necessarily translate to better adaptation. Results also show a moderation effect of sex. Being assigned to the Inhibited profile was associated with decreased externalizing behaviors in boys and increased internalizing behaviors in girls. This study underscores the complexity of self-regulation in sexually abused children and supports the need to adopt a multi-method and multi-informant approach when assessing these children.","PeriodicalId":11265,"journal":{"name":"Development and Psychopathology","volume":" ","pages":"1374-1386"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bidirectional relation of self-regulation with oppositional defiant disorder symptom networks and moderating role of gender. 自我调节与对立违抗障碍症状网络的双向关系及性别的调节作用。

IF 3.1 2区心理学

Development and Psychopathology Pub Date : 2025-08-01 Epub Date: 2024-11-19 DOI: 10.1017/S095457942400172X

Wenrui Zhang, Lu Qiao, Miaomiao Wang, Zaihua Liu, Peilian Chi, Xiuyun Lin

{"title":"Bidirectional relation of self-regulation with oppositional defiant disorder symptom networks and moderating role of gender.","authors":"Wenrui Zhang, Lu Qiao, Miaomiao Wang, Zaihua Liu, Peilian Chi, Xiuyun Lin","doi":"10.1017/S095457942400172X","DOIUrl":"10.1017/S095457942400172X","url":null,"abstract":"Emotion regulation, as a typical \"top-down\" emotional self-regulation, has been shown to play an important role in children's oppositional defiant disorder (ODD) development. However, the association between other self-regulation subcomponents and the ODD symptom network remains unclear. Meanwhile, while there are gender differences in both self-regulation and ODD, few studies have examined whether their relation is moderated by gender. Five hundred and four children (age 6-11 years; 207 girls) were recruited from schools with parents and classroom teachers completing questionnaires and were followed up for assessment six months later. Using moderation network analysis, we analyzed the relation between self-regulation and ODD symptoms, and the moderating role of gender. Self-regulation including emotion regulation, self-control, and emotion lability/negativity had broad bidirectional relations with ODD symptoms. In particular, the bidirectional relations between emotion regulation and ODD3 (Defies) and between emotion lability/negativity and ODD4 (Annoys) were significantly weaker in girls than in boys. Considering the important role of different self-regulation subcomponents in the ODD symptom network, ODD is better conceptualized as a self-regulation disorder. Each ODD symptom is associated with different degrees of impaired \"bottom-up\" and \"top-down\" self-regulation, and several of the associations vary by gender.","PeriodicalId":11265,"journal":{"name":"Development and Psychopathology","volume":" ","pages":"1616-1627"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between language experience variables and the time course of spoken word recognition. 语言经验变量与口语识别时间进程的关系。

IF 2.2 2区心理学

Journal of Experimental Psychology-Learning Memory and Cognition Pub Date : 2025-08-01 Epub Date: 2025-02-13 DOI: 10.1037/xlm0001433

Margarethe McDonald, Tania S Zamuner

{"title":"The relationship between language experience variables and the time course of spoken word recognition.","authors":"Margarethe McDonald, Tania S Zamuner","doi":"10.1037/xlm0001433","DOIUrl":"10.1037/xlm0001433","url":null,"abstract":"During spoken word recognition, words that are related phonologically (e.g., dog and dot) and words that are related semantically (e.g., dog and bear) are known to become active within the first second of word recognition. The time course of activation and resolution of these competing words changes as a function of linguistic knowledge. This preregistered study aimed to examine how a less commonly used linguistic predictor, percent lifetime language exposure, affects the time course of target and competitor activation in an eye-tracking visual world paradigm. Lifetime exposure was expected to capture variability in the representations and processes that contribute to individual differences in spoken word recognition. Results show that when putting lifetime exposure to French on a scale, more lifetime exposure was related to target fixations and slightly related to early phonological coactivation, but not related to semantic coactivation. These analyses demonstrate how generalized additive mixed models might help examine time course data with more continuous linguistic variables. Exploratory analyses looked at the amount of variance captured by three linguistic experience predictors (lifetime French exposure, recent French exposure, French vocabulary) on indices of target, phonological, and semantic fixations and identified vocabulary size as most frequently explaining significant variance, but the pattern of results did not differ from those of lifetime language exposure. These findings suggest that lifetime language exposure may not fully capture subtle differences in linguistic experience that affect lexical coactivation such as those brought upon by differences in exposure trajectories across the lifetime or differences in the setting of language exposure. (PsycInfo Database Record (c) 2025 APA, all rights reserved).","PeriodicalId":50194,"journal":{"name":"Journal of Experimental Psychology-Learning Memory and Cognition","volume":" ","pages":"1303-1323"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitivity to immature skill deficits. Food sharing experiments in squirrel monkeys (Saimiri boliviensis) and common marmosets (Callithrix jacchus). 对未成熟技能缺陷的敏感性。松鼠猴（Saimiri boliviensis）和普通狨猴（Callithrix jacchus）食物分享实验。

IF 1.1 4区心理学

Journal of Comparative Psychology Pub Date : 2025-08-01 Epub Date: 2025-02-13 DOI: 10.1037/com0000399

Sandro Sehner, Erik P Willems, Adrian Baumeyer, Leyla Davis, Carel P van Schaik, Judith M Burkart

{"title":"Sensitivity to immature skill deficits. Food sharing experiments in squirrel monkeys (Saimiri boliviensis) and common marmosets (Callithrix jacchus).","authors":"Sandro Sehner, Erik P Willems, Adrian Baumeyer, Leyla Davis, Carel P van Schaik, Judith M Burkart","doi":"10.1037/com0000399","DOIUrl":"10.1037/com0000399","url":null,"abstract":"Sharing food with immature individuals is costly and should therefore only occur when the benefits outweigh the costs. Accordingly, sharing typically decreases when immature individuals get older and become more proficient independent foragers. Providers would gain more if they could adjust food sharing not only to immature age but also to their skill level. Such sensitivity to others' skill deficits is expected to be rare, but may be found in species with high prosociality and other-regarding preferences, such as cooperative breeders. Here, we compared the food-sharing patterns of cooperatively breeding common marmosets (Callithrix jacchus) and closely related but independently breeding squirrel monkeys (Saimiri boliviensis) under two conditions. In the baseline condition, food was easily accessible whereas in the experimental condition, individuals had to solve a puzzle to access the food. We found that the cooperatively breeding marmosets, but not the independently breeding squirrel monkeys, shared more when immatures lacked the skill to obtain the food from the apparatuses. Skill sensitivity might be associated with the presence of other-regarding preferences and a strong proclivity to proactively share food during baseline conditions. This proclivity has evolved in marmosets, but not squirrel monkeys, in the context of cooperative breeding and may facilitate the emergence of skill recognition, information donation, and teaching. (PsycInfo Database Record (c) 2025 APA, all rights reserved).","PeriodicalId":54861,"journal":{"name":"Journal of Comparative Psychology","volume":" ","pages":"178-191"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Meta-Analysis of the Psychometric Properties of the ICD-11 Compatible Personality Inventory for DSM-5-Brief Form Plus, Modified (PID5BF+M). 针对 DSM-5 的 ICD-11 兼容型人格量表--简表增强版，修订版 (PID5BF+M) 的心理测量特性的元分析。

IF 1.8 3区心理学

Scandinavian journal of psychology Pub Date : 2025-08-01 Epub Date: 2025-02-28 DOI: 10.1111/sjop.13100

Saeid Komasi, Bo Bach

{"title":"A Meta-Analysis of the Psychometric Properties of the ICD-11 Compatible Personality Inventory for DSM-5-Brief Form Plus, Modified (PID5BF+M).","authors":"Saeid Komasi, Bo Bach","doi":"10.1111/sjop.13100","DOIUrl":"10.1111/sjop.13100","url":null,"abstract":"The ICD-11 compatible, Personality Inventory for DSM-5-Brief Form Plus, Modified (PID5BF+M), has recently been developed to assess the constructs of the ICD-11 and DSM-5 maladaptive trait models. This meta-analysis aimed to evaluate the pooled estimates of the structural validity (model fit indices, factor loadings, and internal consistency of individual scales), discriminant validity (factor intercorrelations), and criterion validity (standardized mean differences between clinical and nonclinical samples) of the PID5BF+M. A systematic search for scientific articles published between January 2013 and November 2024 was conducted in PubMed, PsycNET, and Google Scholar. The pooled estimates were calculated using the random effects method following the PRISMA guidelines. The quality of individual studies, heterogeneity, and publication bias were checked. Five high-quality reports including 21 independent samples (3056 patients and 17,361 nonpatients) were entered into the meta-analysis. The six-factor structure of the PID5BF+M was supported by the pooled estimates of model fit (RMSEA = 0.03, CFI = 0.98, TLI = 0.96, and SRMR = 0.01), moderate to very strong factor loadings (from 0.43 to 0.74), and an acceptable internal consistency (ω between 0.70 and 0.79 for all factors with a median of 0.75). The factor intercorrelations were weak to moderate (from 0.05 to 0.38) and the mean scores of most factors (except antagonism) were higher in the patients. The PID5BF+M is an applicable scale to measure maladaptive personality constructs with acceptable structural, discriminant, and criterion validity. Mental health professionals and researchers can use the scale, taking into account some methodological considerations of the present meta-analysis. The study protocol was preregistered in PROSPERO-CRD42024507164.","PeriodicalId":21435,"journal":{"name":"Scandinavian journal of psychology","volume":" ","pages":"482-492"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bidirectional two-sample mendelian randomization analysis identifies a causal relationship between major depressive disorder and allergic diseases. 双向双样本泯灭随机分析确定了重度抑郁症与过敏性疾病之间的因果关系。

IF 3.1 2区心理学

Health Psychology Pub Date : 2025-08-01 Epub Date: 2025-03-27 DOI: 10.1037/hea0001487

Qi Zhang, Ya-Kui Mou, Jia-Jia Yun, Ting Yang, Xiao-Yu Song, Zhen Wang, De-Qin Geng, Xi-Cheng Song, Chao Ren

{"title":"Bidirectional two-sample mendelian randomization analysis identifies a causal relationship between major depressive disorder and allergic diseases.","authors":"Qi Zhang, Ya-Kui Mou, Jia-Jia Yun, Ting Yang, Xiao-Yu Song, Zhen Wang, De-Qin Geng, Xi-Cheng Song, Chao Ren","doi":"10.1037/hea0001487","DOIUrl":"10.1037/hea0001487","url":null,"abstract":"Background: Several studies have indicated an association between major depressive disorder (MDD) and allergic diseases (ADs), but the exact causal relationship remains inconclusive. Thus, this study aimed to explore the causal relationship between MDD and ADs employing bidirectional two-sample Mendelian randomization (MR).Method: The summary statistics for MDD were sourced from the Psychiatric Genomics Consortium. Single nucleotide polymorphisms (SNPs) associated with allergic asthma (AAS), allergic rhinitis (AR), and atopic dermatitis, were extracted from the FinnGen Consortium. The inverse variance weighted was primarily used in this MR analysis, with other methods as supplements. Several sensitivity analyses were performed to evaluate heterogeneity and horizontal pleiotropy. A reverse MR analysis was also conducted.Results: The inverse variance weighted method demonstrated a nominally significant association between MDD and an increased risk of AR (OR = 1.191, 95% confidence interval [CI] [1.006, 1.411], p = .042); after removing the two outlier Single nucleotide polymorphisms, a causal relationship was found between genetic susceptibility to MDD and AAS (OR = 1.418, 95% CI [1.207, 1.666], p = .000022). These results passed the heterogeneity and horizontal pleiotropy tests. However, MDD did not cause atopic dermatitis according to our results (OR = 1.049, 95% CI [0.903, 1.219], p = .53). Furthermore, reverse MR analysis unsupported ADs cause MDD.Conclusion: This MR study suggested a nominally significant causal relationship between MDD and increased risk of AR, and a specific condition-based causal relationship between MDD and AAS. In the future, these results need to be validated further. (PsycInfo Database Record (c) 2025 APA, all rights reserved).","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":"810-820"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leptin-dopamine interactions: unveiling the common link between type-2 diabetes and neuropsychiatric comorbidities. 瘦素-多巴胺相互作用：揭示2型糖尿病和神经精神合并症之间的共同联系。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-07-02 DOI: 10.1097/FBP.0000000000000820

Allyson Gill, Madison Gill, Rahul Mittal, Khemraj Hirani, Ajay Sharma

{"title":"Leptin-dopamine interactions: unveiling the common link between type-2 diabetes and neuropsychiatric comorbidities.","authors":"Allyson Gill, Madison Gill, Rahul Mittal, Khemraj Hirani, Ajay Sharma","doi":"10.1097/FBP.0000000000000820","DOIUrl":"10.1097/FBP.0000000000000820","url":null,"abstract":"Clinical evidence highlights the central nervous system as a key target in type-2 diabetes-related complications, yet the mechanisms underlying the increased prevalence of mood disorder issues, mainly depression, in patients with diabetes remain poorly understood. Leptin, an adiposity hormone known for its role in energy homeostasis, has been shown to improve insulin sensitivity and regulate blood glucose levels in diabetic populations. Beyond its metabolic effects, leptin also has the potential to mitigate psychiatric complications such as depression and anxiety. Notably, leptin receptors are predominantly expressed on dopamine (DA) neurons in the brain, hinting that leptin may orchestrate DA activity by serving as its endogenous modulator. This review examines the role of leptin as a potential common link between type-2 diabetes and mood disorders, particularly through its effects on DA function. This article proposes defective leptin signaling as a vital mechanism contributing to psychiatric complications and compromised DA functions in type-2 diabetes, highlighting leptin as a promising therapeutic target for addressing metabolic and psychiatric comorbidities.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"217-225"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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