IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-10-01 Epub Date: 2025-08-21 DOI: 10.1097/FBP.0000000000000852

Rolffy Ortiz-Andrade, Lilian Dolores Chel-Guerrero, Myrna Déciga-Campos

{"title":"Haloperidol potentates the antinociceptive effect of buprenorphine and tramadol in rats.","authors":"Rolffy Ortiz-Andrade, Lilian Dolores Chel-Guerrero, Myrna Déciga-Campos","doi":"10.1097/FBP.0000000000000852","DOIUrl":"10.1097/FBP.0000000000000852","url":null,"abstract":"This study aimed to evaluate the pharmacological effects of haloperidol on the antinociceptive effects of buprenorphine and tramadol in rats. Dose-response curves were constructed for the individual administration of haloperidol, buprenorphine, and tramadol in rats subjected to the formalin (1%) test. All the compounds demonstrated dose-dependent antinociceptive effects when administered individually. Pharmacological interactions were assessed using an isobolographic method. The doses required to achieve 50% of the maximal antinociceptive effect (ED50) for each drug were combined at a fixed 1 : 1 ratio to establish a combination series of haloperidol + buprenorphine and haloperidol + tramadol. The results showed that buprenorphine achieved a higher maximal antinociceptive effect (98%) compared with tramadol (85%) and haloperidol (84.9%) when administered individually. Isobolographic analysis revealed that the experimental values (Zexp) for haloperidol + buprenorphine (Zadd = 27.6 ± 5.5 vs. Zexp = 5.47 ± 1.2) and haloperidol + tramadol (Zadd = 4987.68 ± 651.5 vs. Zexp = 1678.23 ± 89.8) were significantly lower than the theoretical values (Zadd), indicating synergistic interactions. On the basis of the experimental data, haloperidol potentiated the antinociception in the following order: haloperidol + buprenorphine, followed by haloperidol + tramadol. These findings suggest that such drug combinations could have potential applications in the ongoing research of treatments for chronic pain, depression-related pain, and cancer-associated pain.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"36 7","pages":"517-525"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testing family-of-origin sensitization: Parent-adolescent conflict, emotional reactivity, and adolescent internalizing psychopathology. 原生家庭敏感化测试：亲子冲突、情绪反应和青少年内化精神病理。

IF 3.7 2区心理学

Development and Psychopathology Pub Date : 2025-10-01 Epub Date: 2024-12-04 DOI: 10.1017/S0954579424001779

Shou-Chun Chiang, Sunhye Bai

{"title":"Testing family-of-origin sensitization: Parent-adolescent conflict, emotional reactivity, and adolescent internalizing psychopathology.","authors":"Shou-Chun Chiang, Sunhye Bai","doi":"10.1017/S0954579424001779","DOIUrl":"10.1017/S0954579424001779","url":null,"abstract":"Building on the sensitization hypothesis, the present work aimed to examine how parent-adolescent conflict might be associated with heightened emotional reactivity to peer conflicts, which in turn shape the development of adolescent internalizing psychopathology. Participants were 108 Taiwanese adolescents between the ages of 18 and 19 (Mage = 18.53, SDage = 0.39; 64% female) who completed baseline assessments, 14-day daily surveys, and 6-month follow-up assessments. Emotional reactivity was measured by calculating the daily association between peer conflict and positive and negative emotions. Results indicated that greater baseline parent-adolescent conflict was associated with higher negative emotional reactivity to peer conflicts, which then predicted increased depressive symptoms and anxiety symptoms 6 months later. Moreover, greater positive emotional reactivity to peer conflicts (i.e., more declines in positive emotions in response to peer conflicts) predicted increased depressive symptoms. Thus, the findings of the current study support and extend the sensitization hypothesis and suggest that parent-adolescent conflict may contribute to family-of-origin sensitization in non-familial, interpersonal contexts. The results have key implications for understanding adolescent developmental psychopathology associated with family conflicts and emotional reactivity.","PeriodicalId":11265,"journal":{"name":"Development and Psychopathology","volume":" ","pages":"2172-2180"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interpersonal violence moderates sustained-transient threat co-activation in the vmPFC and amygdala in a community sample of youth. 社区青少年样本中的人际暴力调节了大脑前部皮层和杏仁核中持续-瞬时威胁的共同激活。

IF 3.7 2区心理学

Development and Psychopathology Pub Date : 2025-10-01 Epub Date: 2024-11-26 DOI: 10.1017/S0954579424001743

Nadia Bounoua, Jane E Joseph, Zachary W Adams, Kathleen I Crum, Christopher T Sege, Lisa M McTeague, Greg Hajcak, Colleen A Halliday, Carla Kmett Danielson

{"title":"Interpersonal violence moderates sustained-transient threat co-activation in the vmPFC and amygdala in a community sample of youth.","authors":"Nadia Bounoua, Jane E Joseph, Zachary W Adams, Kathleen I Crum, Christopher T Sege, Lisa M McTeague, Greg Hajcak, Colleen A Halliday, Carla Kmett Danielson","doi":"10.1017/S0954579424001743","DOIUrl":"10.1017/S0954579424001743","url":null,"abstract":"The increased risk for psychopathology associated with interpersonal violence exposure (IPV, e.g., physical abuse, sexual assault) is partially mediated by neurobiological alterations in threat-related processes. Evidence supports parsing neural circuitry related to transient and sustained threat, as they appear to be separable processes with distinct neurobiological underpinnings. Although childhood is a sensitive period for neurodevelopment, most prior work has been conducted in adult samples. Further, it is unknown how IPV exposure may impact transient-sustained threat neural interactions. The current study tested the moderating role of IPV exposure on sustained vmPFC-transient amygdala co-activation during an fMRI task during which threat and neutral cues were predictably or unpredictably presented. Analyses were conducted in a sample of 212 community-recruited youth (M/SDage = 11.77/2.44 years old; 51.9% male; 56.1% White/Caucasian). IPV-exposed youth evidenced a positive sustained vmPFC-transient amygdala co-activation, while youth with no IPV exposure did not show this association. Consistent with theoretical models, effects were specific to unpredictable, negative trials and to exposure to IPV (i.e., unrelated to non-IPV traumatic experiences). Although preliminary, these findings provide novel insight into how childhood IPV exposure may alter neural circuity involved in specific facets of threat processing.","PeriodicalId":11265,"journal":{"name":"Development and Psychopathology","volume":" ","pages":"2151-2160"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating How High Perceived Economic Inequality Exacerbates Intergroup Competition, Zero-Sum Beliefs, and Perceived Intergroup Prejudice. 调查高度感知的经济不平等如何加剧群体间竞争、零和信念和感知的群体间偏见。

IF 2.9 2区心理学

Personality and Social Psychology Bulletin Pub Date : 2025-10-01 Epub Date: 2024-03-27 DOI: 10.1177/01461672241234787

Jaclyn A Lisnek, Nava Caluori, Jazmin L Brown-Iannuzzi, Shigehiro Oishi

{"title":"Investigating How High Perceived Economic Inequality Exacerbates Intergroup Competition, Zero-Sum Beliefs, and Perceived Intergroup Prejudice.","authors":"Jaclyn A Lisnek, Nava Caluori, Jazmin L Brown-Iannuzzi, Shigehiro Oishi","doi":"10.1177/01461672241234787","DOIUrl":"10.1177/01461672241234787","url":null,"abstract":"Rising economic inequality is associated with more prejudice. Little empirical data, however, investigate how inequality affects individuals' psychological processing and, in turn, exacerbates perceptions of prejudice in people's geographic area. We hypothesized that higher perceived economic inequality triggers beliefs that unequal economies are zero-sum and leads to beliefs that people are in competition for limited resources, which may ultimately exacerbate perceived prejudice. Through nine experiments (Studies 1-5 in the manuscript and three additional studies in the Supplement), we provide evidence that higher perceived inequality increases perceived prejudice against a wide range of outgroups. Furthermore, zero-sum beliefs and perceived competition serially mediate this relationship (Studies 2 and 3). In Study 4, we investigate nuance in this hypothesized model by testing whether higher perceived economic inequality exacerbates perceived racial/ethnic prejudice among a large, diverse sample and find a similar pattern of results. Finally (Study 5), we demonstrate that assuaging competition beliefs mitigates perceived prejudice.","PeriodicalId":19834,"journal":{"name":"Personality and Social Psychology Bulletin","volume":" ","pages":"1942-1961"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nostalgia, Ritual Engagement, and Meaning in Life. 怀旧、仪式参与和人生意义。

IF 2.9 2区心理学

Personality and Social Psychology Bulletin Pub Date : 2025-10-01 Epub Date: 2024-03-20 DOI: 10.1177/01461672241235740

Yige Yin, Tonglin Jiang, Tim Wildschut, Constantine Sedikides

引用次数: 0

Ostracism Experiences of Sexual Minorities: Investigating Targets' Experiences and Perceptions by Others. 性少数群体遭受排斥的经历：调查目标的经历和他人的看法。

IF 2.9 2区心理学

Personality and Social Psychology Bulletin Pub Date : 2025-10-01 Epub Date: 2024-04-03 DOI: 10.1177/01461672241240675

Christiane M Büttner, Selma C Rudert, Sven Kachel

引用次数: 0

Interaction effect of lithium and crocin on memory performance and behavioral functions in rats exposed to chronic unpredictable mild stress. 锂和藏红花素对慢性不可预测轻度应激大鼠记忆性能和行为功能的相互作用。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-10-01 Epub Date: 2025-09-03 DOI: 10.1097/FBP.0000000000000848

Delaram Khastoo, Fatemeh Jafari, Batool Ghorbani Yekta, Mahsa Ale-Ebrahim, Soheila Fazli-Tabaei, Salar Vaseghi

{"title":"Interaction effect of lithium and crocin on memory performance and behavioral functions in rats exposed to chronic unpredictable mild stress.","authors":"Delaram Khastoo, Fatemeh Jafari, Batool Ghorbani Yekta, Mahsa Ale-Ebrahim, Soheila Fazli-Tabaei, Salar Vaseghi","doi":"10.1097/FBP.0000000000000848","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000848","url":null,"abstract":"Chronic unpredictable mild stress (CUMS) is an approved method for the induction of depression in rodents. Lithium, as one of the oldest psychiatric drugs, can induce beneficial effects on mood state under stressful conditions. On the other hand, crocin (active component of Saffron) has antioxidant, procognitive, and mood-enhancer effects. In this study, we aimed to investigate the interaction effect of lithium and crocin on mood disturbances and cognitive impairments induced by CUMS. CUMS was performed for 3 weeks. Lithium (100 mg/kg, i.p.), or crocin (30 mg/kg, i.p.), or combination of both was injected during CUMS period (21 injections). Open field test, hot plate, forced swimming test, shuttle box, and Morris water maze were used to evaluate locomotor activity, pain perception, depressive-like behavior, passive avoidance memory, and spatial memory, respectively. The results showed that lithium decreased locomotion and climbing, increased pain threshold and immobility, and impaired passive avoidance and spatial memory in control rats. CUMS also showed all these effects, with more intensity. However, lithium partly reversed the effect of CUMS on locomotion and spatial memory, and completely restored the effect of CUMS on immobility and passive avoidance memory. Also, lithium did not change the effect of CUMS on pain threshold and climbing. Crocin alone, and in combination with lithium significantly reversed all the effects of CUMS. In conclusion, for the first time, the results of the present research showed that the combination of lithium and crocin leads to stronger therapeutic effects on mood disturbances and cognitive impairments induced by chronic stress.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"36 7","pages":"484-499"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal mind-mindedness and infant oxytocin are interrelated and negatively associated with postnatal depression. 母亲的心智和婴儿的催产素相互关联，并与产后抑郁呈负相关。

IF 3.7 2区心理学

Development and Psychopathology Pub Date : 2025-10-01 Epub Date: 2024-10-04 DOI: 10.1017/S0954579424001585

K Lindley Baron-Cohen, P Fearon, E Meins, R Feldman, P Hardiman, C Rosan, P Fonagy

{"title":"Maternal mind-mindedness and infant oxytocin are interrelated and negatively associated with postnatal depression.","authors":"K Lindley Baron-Cohen, P Fearon, E Meins, R Feldman, P Hardiman, C Rosan, P Fonagy","doi":"10.1017/S0954579424001585","DOIUrl":"10.1017/S0954579424001585","url":null,"abstract":"Previous studies show that maternal mind-mindedness positively impacts children's social development. In the current studies, we examine the relation between mind-mindedness during parent-child interaction, oxytocin (OT), and postnatal depression in a sample of mothers (N = 62, ages 23-44) and their infant (ages 3-9 months). In Study 1, infant salivary OT was positively correlated with mothers' appropriate mind-related comments, and negatively correlated (at trend level) with maternal depression scores. Mothers experiencing symptoms of depression used fewer appropriate mind-related comments than controls. Study 2 was a double-blind, placebo-controlled, experimental study, in which the same women who participated in Study 1 were administered nasal OT. This did not significantly influence levels of mind-mindedness. Study 2 warrants a larger trial to investigate the effect of OT on mind-mindedness further. Study 1 is the first to demonstrate an association between maternal mind-mindedness and variation in children's OT levels. Since both OT and mind-mindedness have been repeatedly implicated in processes of maternal-infant attachment, this association highlights the centrality of mothers' caregiving representations in facilitating the parent-child relationship and children's early development.","PeriodicalId":11265,"journal":{"name":"Development and Psychopathology","volume":" ","pages":"2026-2037"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promotive factors associated with reduced anxiety and depression across three years in a prospective clinical cohort of adolescents: Examining compensatory and protective models of resilience. 青少年前瞻性临床队列中与三年内焦虑和抑郁减少相关的促进因素：检验复原力的补偿和保护模式。

IF 3.7 2区心理学

Development and Psychopathology Pub Date : 2025-10-01 Epub Date: 2024-10-07 DOI: 10.1017/S0954579424001469

Ingunn Ranøyen, Jan L Wallander, Stian Lydersen, Per Hove Thomsen, Thomas Jozefiak

{"title":"Promotive factors associated with reduced anxiety and depression across three years in a prospective clinical cohort of adolescents: Examining compensatory and protective models of resilience.","authors":"Ingunn Ranøyen, Jan L Wallander, Stian Lydersen, Per Hove Thomsen, Thomas Jozefiak","doi":"10.1017/S0954579424001469","DOIUrl":"10.1017/S0954579424001469","url":null,"abstract":"The rates of anxiety and depression increase across adolescence, many experience recurrence after treatment, yet longitudinal studies examining promotive factors are scarce. We prospectively examined the role of the promotive factors structured style, personal and social competencies, family functioning, and social resources in homotypic and heterotypic continuity and discontinuity of anxiety and depression across three years in a clinical sample. Participants were adolescents with anxiety or depressive disorders aged 13-18 years at T1 (N = 717, 44% initial participation rate) and aged 16-21 years at T2 (N = 549, 80% follow-up participation rate). At T1, diagnoses were collected from medical records and participants responded to questionnaires. At T2, semi-structured diagnostic interviews were conducted. Higher levels of all promotive factors were associated with reduced probability of anxiety or depression three years later. The promotive factors were not associated with homotypic continuity of anxiety, whereas personal competence beliefs, social competence, and, less strongly, family functioning were associated with reduced homotypic continuity of depression and heterotypic continuity from depression to anxiety. Analyses with interaction terms did not indicate moderation by the promotive factors. Our findings suggest that bolstering promotive factors may be vital for increasing treatment success and preventing recurrence of anxiety and depression in the transition toward adulthood.","PeriodicalId":11265,"journal":{"name":"Development and Psychopathology","volume":" ","pages":"1903-1918"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timing sensitivity of prenatal cortisol exposure and neurocognitive development. 产前皮质醇暴露与神经认知发育的时间敏感性

IF 3.7 2区心理学

Development and Psychopathology Pub Date : 2025-10-01 Epub Date: 2024-11-06 DOI: 10.1017/S0954579424001287

Sean R Womack, Hannah R Murphy, Molly S Arnold, Zoe T Duberstein, Meghan Best, Xing Qiu, Richard K Miller, Emily S Barrett, Thomas G O'Connor

{"title":"Timing sensitivity of prenatal cortisol exposure and neurocognitive development.","authors":"Sean R Womack, Hannah R Murphy, Molly S Arnold, Zoe T Duberstein, Meghan Best, Xing Qiu, Richard K Miller, Emily S Barrett, Thomas G O'Connor","doi":"10.1017/S0954579424001287","DOIUrl":"10.1017/S0954579424001287","url":null,"abstract":"Prenatal glucocorticoid exposure has been negatively associated with infant neurocognitive outcomes. However, questions about developmental timing effects across gestation remain. Participants were 253 mother-child dyads who participated in a prospective cohort study recruited in the first trimester of pregnancy. Diurnal cortisol was measured in maternal saliva samples collected across a single day within each trimester of pregnancy. Children (49.8% female) completed the Bayley Mental Development Scales, Third Edition at 6, 12, and 24 months and completed three observational executive function tasks at 24 months. Structural equation models adjusting for sociodemographic covariates were used to test study hypotheses. There was significant evidence for timing sensitivity. First-trimester diurnal cortisol (area under the curve) was negatively associated with cognitive and language development at 12 months and poorer inhibition at 24 months. Second-trimester cortisol exposure was negatively associated with language scores at 24 months. Third-trimester cortisol positively predicted performance in shifting between task rules (set shifting) at 24 months. Associations were not reliably moderated by child sex. Findings suggest that neurocognitive development is sensitive to prenatal glucocorticoid exposure as early as the first trimester and underscore the importance of assessing developmental timing in research on prenatal exposures for child health outcomes.","PeriodicalId":11265,"journal":{"name":"Development and Psychopathology","volume":" ","pages":"1707-1720"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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