A comprehensive characterization of cognitive performance, clinical symptoms, and cortical activity following mild traumatic brain injury (mTBI).

IF 1.5 4区心理学 Q4 CLINICAL NEUROLOGY

Applied Neuropsychology-Adult Pub Date : 2025-09-01 Epub Date: 2023-11-28 DOI:10.1080/23279095.2023.2286493

Hannah L Coyle, Neil W Bailey, Jennie Ponsford, Kate E Hoy

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引用次数: 0

Abstract

Objective: The objective of this study was to investigate clinical symptoms, cognitive performance and cortical activity following mild traumatic brain injury (mTBI).

Methods: We recruited 30 individuals in the sub-acute phase post mTBI and 28 healthy controls with no history of head injury and compared these groups on clinical, cognitive and cortical activity measures. Measures of cortical activity included; resting state electroencephalography (EEG), task related EEG and combined transcranial magnetic stimulation with electroencephalography (TMS-EEG). Primary analyses investigated clinical, cognitive and cortical activity differences between groups. Exploratory analyses investigated the relationships between these measures.

Results: At 4 weeks' post injury, mTBI participants exhibited significantly greater post concussive and clinical symptoms compared to controls; as well as reduced cognitive performance on verbal learning and working memory measures. mTBI participants demonstrated alterations in cortical activity while at rest and in response to stimulation with TMS.

Conclusions: The present study comprehensively characterized the multidimensional effect of mTBI in the sub-acute phase post injury, showing a broad range of differences compared to non-mTBI participants. Further research is needed to explore the relationship between these pathophysiologies and clinical/cognitive symptoms in mTBI.

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轻度创伤性脑损伤(mTBI)后认知表现、临床症状和皮质活动的综合特征

目的:本研究的目的是探讨轻度创伤性脑损伤(mTBI)后的临床症状、认知表现和皮层活动。方法:我们招募了30名mTBI后亚急性期的个体和28名没有头部损伤史的健康对照者，并比较了这些组的临床、认知和皮层活动测量。包括对皮质活动的测量;静息状态脑电图(EEG)、任务相关脑电图(EEG)和经颅磁刺激联合脑电图(TMS-EEG)。初步分析调查了两组之间临床、认知和皮层活动的差异。探索性分析调查了这些措施之间的关系。结果:在损伤后4周，与对照组相比，mTBI参与者表现出明显更大的脑震荡后和临床症状;同时在语言学习和工作记忆方面的认知表现也会下降。mTBI参与者在休息时和对经颅磁刺激的反应中表现出皮层活动的改变。结论:本研究全面表征了mTBI在损伤后亚急性期的多维影响，与非mTBI参与者相比，显示出广泛的差异。需要进一步研究这些病理生理与mTBI临床/认知症状之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY

CiteScore

4.50

自引率

11.80%

发文量

134

期刊介绍： pplied Neuropsychology-Adult publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in adults. Full-length articles and brief communications are included. Case studies of adult patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.