Cell stem cell最新文献_第4页

Ovarian aging and systemic health: Mechanisms and emerging intervention strategies 卵巢老化和全身健康：机制和新兴的干预策略

IF 23.9 1区医学

Cell stem cell Pub Date : 2026-08-17 DOI: 10.1016/j.stem.2026.07.013

Ying Jing, Jing Qu, Si Wang, Guang-Hui Liu

引用次数: 0

Vitamin C attenuates primate bone marrow aging at the molecular and progenitor level 维生素C在分子和祖细胞水平上减缓灵长类动物骨髓老化

IF 23.9 1区医学

Cell stem cell Pub Date : 2026-07-16 DOI: 10.1016/j.stem.2026.06.006

Yanxia Ye, Honghao Zhang, Zijuan Xin, Wanling Sun, Lixiao Liu, Muzhao Xiong, Hongkai Zhao, Yiyuan Zhang, Jiaqi Geng, Liyun Zhao, Jingyi Li, Xiaoyu Jiang, Yuesheng Zuo, Shuai Ma, Hongjia Zhang, Si Wang, Guoguang Zhao, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Guang-Hui Liu

引用次数: 0

Human iPSC-derived engineered heart tissue model of diastolic dysfunction in heart failure with preserved ejection fraction 保存射血分数的心力衰竭患者舒张功能障碍的人ipsc工程化心脏组织模型

IF 23.9 1区医学

Cell stem cell Pub Date : 2026-07-16 DOI: 10.1016/j.stem.2026.06.007

Hidenori Tani, Kotaro Haga, Taijun Moriwaki, Uikyu Bang, Shohei Fujii, Daichi Sekiguchi, Yuki Yamamoto, Kuniko Momoi, Masatoshi Ohno, Masashi Nakamura, Tomohiko C. Umei, Yuika Morita-Umei, Yusuke Soma, Yoshikazu Kishino, Motoaki Sano, Keiichi Fukuda, Akitsu Hotta, Masaki Ieda, Shugo Tohyama

引用次数: 0

FDA-approved fulvestrant-induced CAR phase separation enables precise control of CAR T antitumor function. fda批准的氟维司汀诱导的CAR相分离能够精确控制CAR T抗肿瘤功能。

IF 23.9 1区医学

Cell stem cell Pub Date : 2026-07-10 DOI: 10.1016/j.stem.2026.06.005

Yuwei Huang,Qichen Zhang,Kun Wang,Xiaohua Ren,Hao He,Jinjiao Wang,Li Li,Zhichao Tan,Jiayong Liu,Guangya Zhu,Haopeng Wang

{"title":"FDA-approved fulvestrant-induced CAR phase separation enables precise control of CAR T antitumor function.","authors":"Yuwei Huang,Qichen Zhang,Kun Wang,Xiaohua Ren,Hao He,Jinjiao Wang,Li Li,Zhichao Tan,Jiayong Liu,Guangya Zhu,Haopeng Wang","doi":"10.1016/j.stem.2026.06.005","DOIUrl":"https://doi.org/10.1016/j.stem.2026.06.005","url":null,"abstract":"Chimeric antigen receptor (CAR) T cell therapy faces challenges, such as tumor relapse due to antigen loss and poor CAR T cell expansion in vivo. Optimal tonic signaling (spontaneous CAR signaling) is crucial for CAR T cell fitness and antitumor function, requiring precise calibration to avoid dysfunction or exhaustion. Although CAR phase separation can enhance CAR clustering and tonic signaling to improve cytotoxicity and antigen sensitivity, constitutively high signaling could lead to potential side effects, including cytokine storm and neuronal toxicity. To overcome this limitation, we developed a drug-inducible phase-separation CAR (iPhase-CAR) system utilizing FDA-approved fulvestrant and an engineered estrogen receptor α (ERα) mutant as the drug-inducible phase-separation (DiPS) module. Incorporating the DiPS module into CARs enables drug-inducible clustering of CARs on T cell membranes. iPhase-CAR T cells demonstrate superior antitumor function. This system provides quantitative, reversible promotion of CAR T effector functions, enabling precise control over therapeutic efficacy only upon administration of the FDA-approved drug.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"44 1","pages":""},"PeriodicalIF":23.9,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148415957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generation of spermatogonia from human and non-human primate pluripotent stem cells. 人类和非人类灵长类多能干细胞产生精原细胞。

IF 23.9 1区医学

Cell stem cell Pub Date : 2026-07-10 DOI: 10.1016/j.stem.2026.06.001

Eoin C Whelan,Mingyue Guo,Ryo Yokomizo,Yasunari Seita,Young Sun Hwang,Yuichiro Shirafuta,N Adrian Leu,Keren Cheng,Franziska Ahrend,Astrid D Haase,Kotaro Sasaki

{"title":"Generation of spermatogonia from human and non-human primate pluripotent stem cells.","authors":"Eoin C Whelan,Mingyue Guo,Ryo Yokomizo,Yasunari Seita,Young Sun Hwang,Yuichiro Shirafuta,N Adrian Leu,Keren Cheng,Franziska Ahrend,Astrid D Haase,Kotaro Sasaki","doi":"10.1016/j.stem.2026.06.001","DOIUrl":"https://doi.org/10.1016/j.stem.2026.06.001","url":null,"abstract":"Failures in germline development drive male infertility, but the lack of model systems that recapitulate human spermatogenesis hampers therapeutic development. Here, we develop a system to differentiate human-induced pluripotent stem cells (iPSCs) into primordial germ cell-like cells that self-organize with mouse fetal testicular cells into seminiferous tubule-like structures within a xenogeneic reconstituted testis (xrTestis). Subsequent transplantation of xrTestes into immunodeficient mice results in efficient generation of male germ cells up to meiotic onset, including spermatogonia with evidence of prepachytene PIWI-interacting RNA (piRNA) biogenesis, as well as differentiating spermatogonia and rare preleptotene spermatocytes exhibiting transcriptomic and phenotypic similarities to their in vivo counterparts. As future clinical applications will require testing in non-human primates, we apply a similar strategy to differentiate rhesus iPSCs through fetal germ cell stages into spermatogonia and differentiating spermatogonia. Together, these platforms provide a foundation for studying primate germ cell lineages and represent a step toward in vitro gametogenesis.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"321 1","pages":""},"PeriodicalIF":23.9,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148415958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From reconstruction to intervention: Engineered organoids as living therapeutic depots. 从重建到干预：工程类器官作为活生生的治疗仓库。

IF 23.9 1区医学

Cell stem cell Pub Date : 2026-07-02 DOI: 10.1016/j.stem.2026.05.015

Lu Wang,Yan Pang,Jinyao Liu

引用次数: 0

From repair to relay: Human retinal organoids re-couple a severed optic nerve. 从修复到中继：人类视网膜类器官将切断的视神经重新连接起来。

IF 23.9 1区医学

Cell stem cell Pub Date : 2026-07-02 DOI: 10.1016/j.stem.2026.05.008

Kevin Achberger,Stefan Liebau

引用次数: 0

Outside the niche: Gut microbiota relay psychological stress to hematopoietic stem cell dysfunction. 生态位外：肠道微生物群将心理压力传递给造血干细胞功能障碍。

IF 23.9 1区医学

Cell stem cell Pub Date : 2026-07-02 DOI: 10.1016/j.stem.2026.06.004

Haiyan Zhou,Yuxi Wei,Dachuan Zhang

引用次数: 0

Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone marrow axis. 心理压力通过脑-肠-骨髓轴驱动衰老样造血干细胞功能障碍。

IF 23.9 1区医学

Cell stem cell Pub Date : 2026-07-02 DOI: 10.1016/j.stem.2026.05.012

Xiaobin Tian,Binghuo Wu,Keyue Yang,Ying Wang,Yishan Li,Jingjing Guan,Kaitao Wang,Yijun Zhao,Kexin Sun,Yanjun Ling,Jiayin Zheng,Mengyun Xie,Weiming Liu,Xiaojing Ye,Changzheng Li,Linjia Jiang,Meng Zhao

{"title":"Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone marrow axis.","authors":"Xiaobin Tian,Binghuo Wu,Keyue Yang,Ying Wang,Yishan Li,Jingjing Guan,Kaitao Wang,Yijun Zhao,Kexin Sun,Yanjun Ling,Jiayin Zheng,Mengyun Xie,Weiming Liu,Xiaojing Ye,Changzheng Li,Linjia Jiang,Meng Zhao","doi":"10.1016/j.stem.2026.05.012","DOIUrl":"https://doi.org/10.1016/j.stem.2026.05.012","url":null,"abstract":"Chronic stress influences hematopoietic stem cells (HSCs). However, how psychological stress regulates HSC function remains incompletely understood. Here, we show that psychological stress impairs HSC self-renewal and lymphoid differentiation, inducing aging-like phenotypes. Stress suppresses neuronal activity in the medial prefrontal cortex (mPFC) and periaqueductal gray (PAG), leading to HSC dysfunction, whereas chemogenetic activation of these regions restores HSC function. Psychological stress or chemogenetic inhibition of the mPFC and PAG reduces the abundance of L. reuteri in the gut microbiota and lowers spermidine levels. Mechanistically, spermidine depletion suppresses mitochondrial autophagy, promotes mitochondrial peroxidative stress, and increases ferroptotic stress in HSCs. We further demonstrate that mPFC and PAG activity regulate the intestinal environment through a sympathetic pathway, reducing intestinal mucin levels, L. reuteri abundance, and spermidine levels. These findings identify a brain-gut-bone marrow axis linking psychological stress to aging-like HSC dysfunction through sympathetic regulation of intestinal microbiota and spermidine metabolism.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"11 1","pages":"1205-1222.e11"},"PeriodicalIF":23.9,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148372701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling human hypothalamic cell diversity through developmental patterning. 通过发育模式模拟人类下丘脑细胞多样性。

IF 23.9 1区医学

Cell stem cell Pub Date : 2026-07-02 DOI: 10.1016/j.stem.2026.06.003

Sol Díaz de León-Guerrero,Zhiping P Pang

引用次数: 0