发布求助
文献互助 智能选刊 最新文献

Cell stem cell最新文献

筛选
英文 中文
Unmasking cancer’s hidden nerve route with patient-derived organoids 用病人来源的类器官揭示癌症隐藏的神经通路
IF 23.9 1区 医学
Cell stem cell Pub Date : 2025-10-02 DOI: 10.1016/j.stem.2025.08.008
Kevin M. Waters, Akil Merchant, De-Chen Lin
{"title":"Unmasking cancer’s hidden nerve route with patient-derived organoids","authors":"Kevin M. Waters, Akil Merchant, De-Chen Lin","doi":"10.1016/j.stem.2025.08.008","DOIUrl":"https://doi.org/10.1016/j.stem.2025.08.008","url":null,"abstract":"Chan et al.<span><span><sup>1</sup></span></span> show that enteric neurons influence lipid metabolism in gastric cancer organoids, affecting dependencies on key enzymes. Using CRISPR screening and metabolic analysis, their work highlights how microenvironmental signals impact tumor metabolism and potential treatment targets in gastric cancer.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"10 1","pages":""},"PeriodicalIF":23.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mind, mood and new neurons: Probing adult hippocampal neurogenesis in neuropsychiatry and beyond 心智、情绪和新神经元：在神经精神病学及其他领域探索成人海马神经发生
IF 23.9 1区 医学
Cell stem cell Pub Date : 2025-10-02 DOI: 10.1016/j.stem.2025.09.005
Giorgia Tosoni, Evgenia Salta
{"title":"Mind, mood and new neurons: Probing adult hippocampal neurogenesis in neuropsychiatry and beyond","authors":"Giorgia Tosoni, Evgenia Salta","doi":"10.1016/j.stem.2025.09.005","DOIUrl":"https://doi.org/10.1016/j.stem.2025.09.005","url":null,"abstract":"In this issue of <em>Cell Stem Cell</em>, Márquez-Valadez, Gallardo-Caballero, and Llorens-Martín<span><span><sup>1</sup></span></span> report that adult hippocampal neurogenesis (AHN) is differentially disrupted in neuropsychiatric disorders. Their findings highlight the role of the neurogenic niche and lifestyle, supporting the view of human AHN as a dynamic process sensitive to biology and behavior.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"9 1","pages":""},"PeriodicalIF":23.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stem cell research in space: Advancing regenerative medicine beyond Earth 太空中的干细胞研究：在地球之外推进再生医学
IF 23.9 1区 医学
Cell stem cell Pub Date : 2025-10-02 DOI: 10.1016/j.stem.2025.09.001
Maedeh Mozneb, Madelyn Arzt, Jemima Moses, Sean Escopete, Lauren Wiegand, Arun Sharma
{"title":"Stem cell research in space: Advancing regenerative medicine beyond Earth","authors":"Maedeh Mozneb, Madelyn Arzt, Jemima Moses, Sean Escopete, Lauren Wiegand, Arun Sharma","doi":"10.1016/j.stem.2025.09.001","DOIUrl":"https://doi.org/10.1016/j.stem.2025.09.001","url":null,"abstract":"Spaceflight provides a unique environment that profoundly influences stem cell biology. Experiments aboard the International Space Station (ISS) and in simulated microgravity have revealed altered stem cell proliferation, differentiation, and stress responses, unveiling possibilities for modeling impacts of spaceflight and harnessing microgravity for biomanufacturing. Stem cell-derived organoids and tissue models flown in space are yielding insights into development, disease, and aging mechanisms, while in-space biomanufacturing efforts demonstrate accelerated stem cell expansion and tissue formation for potential translational and clinical applications. Finally, as humanity prepares for long-duration lunar and Martian missions, space-based stem cell research offers transformative biomedical applications but also raises new technical, regulatory, workforce development, and ethical challenges.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"157 1","pages":""},"PeriodicalIF":23.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Raising the bar for human post-implantation embryo models 提高人类胚胎植入后模型的门槛
IF 23.9 1区 医学
Cell stem cell Pub Date : 2025-10-02 DOI: 10.1016/j.stem.2025.09.002
{"title":"Raising the bar for human post-implantation embryo models","authors":"","doi":"10.1016/j.stem.2025.09.002","DOIUrl":"https://doi.org/10.1016/j.stem.2025.09.002","url":null,"abstract":"The generation of stem-cell-based embryo models has ushered in a new era for human embryology, but improving their reproducibility and lineage fidelit…","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"18 1","pages":""},"PeriodicalIF":23.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Building the start: Unlocking advanced stem cell-based embryo models 建立开端：解锁先进的基于干细胞的胚胎模型
IF 23.9 1区 医学
Cell stem cell Pub Date : 2025-10-02 DOI: 10.1016/j.stem.2025.08.016
Zekun Wu, Hongan Ren, Leqian Yu
{"title":"Building the start: Unlocking advanced stem cell-based embryo models","authors":"Zekun Wu, Hongan Ren, Leqian Yu","doi":"10.1016/j.stem.2025.08.016","DOIUrl":"https://doi.org/10.1016/j.stem.2025.08.016","url":null,"abstract":"Two recent studies from the Silva and Hanna groups optimized chemical induction and culture conditions to derive extraembryonic lineages directly from embryonic stem cells (ESCs) without transgenes, enabling mouse stem cell-based embryo models (SCBEMs) to reproducibly advance to the E8.5–E8.75 stage.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"114 1","pages":""},"PeriodicalIF":23.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From sentinels to engineers: The future of microglia in brain regeneration 从哨兵到工程师：小胶质细胞在大脑再生中的未来
IF 23.9 1区 医学
Cell stem cell Pub Date : 2025-10-02 DOI: 10.1016/j.stem.2025.09.004
Muzhen Qiao, Peng Jiang
{"title":"From sentinels to engineers: The future of microglia in brain regeneration","authors":"Muzhen Qiao, Peng Jiang","doi":"10.1016/j.stem.2025.09.004","DOIUrl":"https://doi.org/10.1016/j.stem.2025.09.004","url":null,"abstract":"Recent studies highlight microglial replacement as a promising therapeutic approach for neurological disease. Wu et al.<span><span><sup>1</sup></span></span> demonstrated that transplanted bone marrow-derived cells halted ALSP progression, while Mader et al.<span><span><sup>2</sup></span></span> introduced a strategy that avoids systemic bone marrow ablation toxicity and reduces immune rejection, collectively validating this strategy’s therapeutic potential.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"7 1","pages":""},"PeriodicalIF":23.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From form to function: New heights in kidney organoids 从形态到功能：肾类器官的新高度
IF 23.9 1区 医学
Cell stem cell Pub Date : 2025-10-02 DOI: 10.1016/j.stem.2025.09.003
Jonathan Levinsohn, Katalin Susztak
{"title":"From form to function: New heights in kidney organoids","authors":"Jonathan Levinsohn, Katalin Susztak","doi":"10.1016/j.stem.2025.09.003","DOIUrl":"https://doi.org/10.1016/j.stem.2025.09.003","url":null,"abstract":"In this issue of <em>Cell Stem Cell</em>, Huang et al.<span><span><sup>1</sup></span></span> address the challenge of creating organoids that more closely replicate kidney spatial patterning and function. They develop region-specific progenitor assembloids mimicking native architecture. After transplantation into mice, which further promotes differentiation, they demonstrate functional and disease modeling capability.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"126 1","pages":""},"PeriodicalIF":23.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A mineralizing pool of Gli1-expressing progenitors builds the tendon enthesis and demonstrates therapeutic potential 矿化池的gli1表达祖细胞建立肌腱终结和显示治疗潜力
IF 23.9 1区 医学
Cell stem cell Pub Date : 2025-09-30 DOI: 10.1016/j.stem.2025.09.010
Fei Fang, Yang Xiao, Elazar Zelzer, Kam W. Leong, Stavros Thomopoulos
{"title":"A mineralizing pool of Gli1-expressing progenitors builds the tendon enthesis and demonstrates therapeutic potential","authors":"Fei Fang, Yang Xiao, Elazar Zelzer, Kam W. Leong, Stavros Thomopoulos","doi":"10.1016/j.stem.2025.09.010","DOIUrl":"https://doi.org/10.1016/j.stem.2025.09.010","url":null,"abstract":"(Cell Stem Cell <em>29</em>, 1669–1684.e1–e6; December 1, 2022)","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"104 1","pages":""},"PeriodicalIF":23.9,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting lysozyme 2 in endocardium promotes rapid recovery by modulating remote injury signals 靶向溶菌酶2在心内膜通过调节远程损伤信号促进快速恢复
IF 23.9 1区 医学
Cell stem cell Pub Date : 2025-09-17 DOI: 10.1016/j.stem.2025.08.015
Chenghao Fan, Shen Song, Yu Han, Dongcheng Cai, Anteng Shi, Fangfang Wan, Jie Feng, Jiajun Zhong, Yifan Xie, Fei Xu, Jiangping Song, Shengshou Hu, Yu Nie, Hui Zhang
{"title":"Targeting lysozyme 2 in endocardium promotes rapid recovery by modulating remote injury signals","authors":"Chenghao Fan, Shen Song, Yu Han, Dongcheng Cai, Anteng Shi, Fangfang Wan, Jie Feng, Jiajun Zhong, Yifan Xie, Fei Xu, Jiangping Song, Shengshou Hu, Yu Nie, Hui Zhang","doi":"10.1016/j.stem.2025.08.015","DOIUrl":"https://doi.org/10.1016/j.stem.2025.08.015","url":null,"abstract":"Adult mammalian hearts are non-regenerative, and a majority of studies examining repair and potential regeneration post-myocardial infarction (MI) have focused on cardiomyocyte (CM) proliferation and infarcted zones. Here, we observed aberrantly high expression of lysozyme 2 (<em>Lyz2</em>) in injured mouse hearts at both local injury sites and at remote zones, with sustained <em>Lyz2</em> expression conspicuous in endocardial cells of non-regenerative hearts. Although traditionally conceptualized as a myeloid marker, we demonstrate that LYZ2 functions as an injury-specific, positive regulator of lysosomal degradation capacity that mediates pathogenic degradation of the extracellular matrix. We observed an anti-apoptotic benefit to CMs upon disrupting LYZ2/LYZ function in mice and in a human endomyocardium experimental model. Harnessing these insights, we show that both <em>Lyz2</em> knockout (KO) and pharmacological inhibition of lysosomal degradation confer rapid functional recovery in injured non-regenerative hearts. Thus, targeting a remote injury response in a non-CM cell type rapidly promotes post-MI recovery of non-regenerative hearts.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"37 1","pages":""},"PeriodicalIF":23.9,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145072419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatially patterned kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling 空间模式的肾脏组装体概括了祖细胞的自组装，并实现了高保真的体内疾病建模
IF 23.9 1区 医学
Cell stem cell Pub Date : 2025-09-17 DOI: 10.1016/j.stem.2025.08.013
Biao Huang, Pedro Medina, Jincan He, Zipeng Zeng, Sunghyun Kim, Janet Romo, Kari Koppitch, Chennan C. Zhang, Georgina Gyarmati, Yohan Park, Ruslan Bohovyk, Pierre-Emmanuel Yoann N’Guetta, Jinjin Guo, Tianyi Ma, Megan E. Schreiber, Cong Xu, Jessica Pham, Riana K. Parvez, Jackson Su, Mateo W. Xia, Zhongwei Li
{"title":"Spatially patterned kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling","authors":"Biao Huang, Pedro Medina, Jincan He, Zipeng Zeng, Sunghyun Kim, Janet Romo, Kari Koppitch, Chennan C. Zhang, Georgina Gyarmati, Yohan Park, Ruslan Bohovyk, Pierre-Emmanuel Yoann N’Guetta, Jinjin Guo, Tianyi Ma, Megan E. Schreiber, Cong Xu, Jessica Pham, Riana K. Parvez, Jackson Su, Mateo W. Xia, Zhongwei Li","doi":"10.1016/j.stem.2025.08.013","DOIUrl":"https://doi.org/10.1016/j.stem.2025.08.013","url":null,"abstract":"Current kidney organoids do not recapitulate the kidney’s complex spatial patterning and function, limiting their applications. The human kidney comprises one million nephrons, derived from nephron progenitor cells, that connect to an arborized ureteric progenitor cell-derived collecting system. Here, we develop spatially organized mouse and human kidney progenitor assembloid (KPA) models in which the nephrons undergo extensive development and fuse to a centrally located collecting system, recapitulating kidney progenitor self-assembly processes observed <em>in vivo</em>. KPAs show dramatically improved cellular complexity and maturity and exhibit several aspects of major kidney functions <em>in vitro</em> and <em>in vivo</em>. Modeling human autosomal dominant polycystic kidney disease (ADPKD) with genome-edited, <em>in vivo</em>-grown human KPAs recapitulated the cystic phenotype and the molecular and cellular hallmarks of the disease and highlighted the crosstalk among cyst epithelium, stroma, and macrophages. The KPA platform opens new avenues for high-fidelity disease modeling and lays a strong foundation for kidney regenerative medicine.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"52 1","pages":""},"PeriodicalIF":23.9,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145072418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信