Toward building kidney organoids with plumbing: Fusion of nephron with ureteric bud

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-07-03 DOI:10.1016/j.stem.2025.06.001

Chao Zhang, Yun Xia

引用次数: 0

Abstract

The fusion of distal nephron and ureteric bud represents a critical developmental milestone required for establishing a functional kidney plumbing system. In this issue of Cell Stem Cell, Shi et al.¹ report a protocol for generating human kidney organoids with an integrated collecting system by recapitulating this key developmental fusion event.

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构建有管道的类肾器官：肾元与输尿管芽的融合

远端肾元与输尿管芽的融合是一个重要的发育里程碑，需要建立一个功能性的肾管道系统。在这一期的《细胞干细胞》杂志上，Shi等人1报道了一项通过总结这一关键的发育融合事件，通过集成收集系统生成人类肾类器官的方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.