干细胞老化的特征

IF 19.8 1区 医学 Q1 CELL & TISSUE ENGINEERING
Thomas A. Rando, Anne Brunet, Margaret A. Goodell
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引用次数: 0

摘要

随着生物体衰老,体细胞干细胞逐渐失去维持组织稳态和支持再生的能力。尽管与分化的后代相比,干细胞相对不受某些细胞衰老机制的影响,但它们仍然容易受到内在和外在压力因素的影响。在这篇综述中,我们描述了衰老干细胞的五个主要特征,并研究了这些变化是如何在经过充分研究的干细胞区室中导致功能下降的。这些特征不仅提供了对衰老过程的深入了解,而且为旨在恢复干细胞功能和延长组织健康跨度的治疗策略提供了有希望的目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hallmarks of stem cell aging
As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are relatively shielded from some cellular aging mechanisms compared with their differentiated progeny, they remain vulnerable to both intrinsic and extrinsic stressors. In this review, we delineate five cardinal features that characterize aged stem cells and examine how these alterations underlie functional decline across well-studied stem cell compartments. These hallmarks not only provide insight into the aging process but also serve as promising targets for therapeutic strategies aimed at rejuvenating stem cell function and extending tissue health span.
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来源期刊
Cell stem cell
Cell stem cell 生物-细胞生物学
CiteScore
37.10
自引率
2.50%
发文量
151
审稿时长
42 days
期刊介绍: Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.
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