Cell stem cellPub Date : 2026-01-08DOI: 10.1016/j.stem.2025.12.015
Salome Stierli,Adrian Salas-Bastos,Sofia Micheli,Isabel Ballwein,Andrea Kelemen,Julia Lehmann,Benjamin Loos,Whitney Shannon Jordaan,Sebastian A Stifter,Myriam Gwerder,Ravidu Nakandalage,Janine Stadler,Melanie Greter,Lukas Sommer
{"title":"A peripheral glial niche orchestrates the early stages of skin wound healing.","authors":"Salome Stierli,Adrian Salas-Bastos,Sofia Micheli,Isabel Ballwein,Andrea Kelemen,Julia Lehmann,Benjamin Loos,Whitney Shannon Jordaan,Sebastian A Stifter,Myriam Gwerder,Ravidu Nakandalage,Janine Stadler,Melanie Greter,Lukas Sommer","doi":"10.1016/j.stem.2025.12.015","DOIUrl":"https://doi.org/10.1016/j.stem.2025.12.015","url":null,"abstract":"Skin repair is a complex, dynamic process involving multiple cell types. Using multiplex imaging, spatial transcriptomics, and single-cell RNA sequencing, we show that peripheral nerves-containing repair glia-form a pro-reparative niche closely interacting with macrophages and proliferating fibroblasts in acute skin wounds. Repair glia function as critical early-stage regulators of wound healing by initiating the inflammatory response through secretion of monocyte chemoattractant proteins, such as CCL2, which recruit monocyte-derived macrophages. Accordingly, depletion of repair glia as well as glia-specific deletion of CCL2 reduces the number of macrophages, leading to impaired fibroblast proliferation and diminished fibroblast-to-myofibroblast transition. These findings identify repair glia as early regulators of the immune response, orchestrating the spatiotemporal progression of wound healing.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"86 1","pages":""},"PeriodicalIF":23.9,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell stem cellPub Date : 2026-01-08DOI: 10.1016/j.stem.2025.12.009
Da Wang,Yufan Zhang,Yan Liu
{"title":"Pineal gland organoids illuminate human melatonin and circadian regulation.","authors":"Da Wang,Yufan Zhang,Yan Liu","doi":"10.1016/j.stem.2025.12.009","DOIUrl":"https://doi.org/10.1016/j.stem.2025.12.009","url":null,"abstract":"Human pineal development and neuroendocrine regulation remain incompletely understood at the molecular and functional levels. Kiral et al.1 establish human pineal gland organoids (hPGOs) that recapitulate pinealocyte maturation, noradrenergic responsiveness, and melatonin synthesis, providing a platform for investigating circadian dysfunction and disease-associated sleep disturbances.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"47 1","pages":"4-6"},"PeriodicalIF":23.9,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell stem cellPub Date : 2026-01-08DOI: 10.1016/j.stem.2025.12.012
Junsung Nam,Roy Simamora,Fikri Birey
{"title":"Reverse engineering the beat: Assembloid modeling of sympathetic control of the heart.","authors":"Junsung Nam,Roy Simamora,Fikri Birey","doi":"10.1016/j.stem.2025.12.012","DOIUrl":"https://doi.org/10.1016/j.stem.2025.12.012","url":null,"abstract":"Liu et al.1 generate human sympathetic ganglion organoids and assemble them with heart-forming organoids to build functionally connected sympathetic-cardiac organoids in vitro. Their platform captures autonomic development, neuromodulation of heart function, and metabolic injury, opening new opportunities to study human autonomic disorders and cardiometabolic disease.2.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"29 1","pages":"1-3"},"PeriodicalIF":23.9,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell stem cellPub Date : 2026-01-08DOI: 10.1016/j.stem.2025.12.011
Monika Haoui,Pradeep Reddy,Juan Carlos Izpisua Belmonte
{"title":"Anti-aging strategies and ex vivo organ rejuvenation.","authors":"Monika Haoui,Pradeep Reddy,Juan Carlos Izpisua Belmonte","doi":"10.1016/j.stem.2025.12.011","DOIUrl":"https://doi.org/10.1016/j.stem.2025.12.011","url":null,"abstract":"Aging is characterized by a progressive decline in physiological function, driven by interconnected molecular hallmarks that increase the risk of chronic diseases. To extend health span, interventions targeting these hallmarks, including lifestyle modifications, pharmacological agents, and genetic strategies, have been developed. Among these, partial reprogramming, the transient expression of Yamanaka factors, has emerged as a powerful approach to reverse age-related cellular damage and restore youthful epigenetic and transcriptional signatures without erasing cell identity. This perspective highlights the therapeutic possibilities arising from the convergence of partial reprogramming with the innovative technology of ex vivo machine perfusion. These platforms offer a unique opportunity to apply rejuvenation therapies directly to suboptimal donor organs outside the body before transplantation. Combining these strategies could significantly improve organ quality, expand the donor pool, enhance transplantation outcomes, and advance regenerative medicine.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"49 1","pages":"13-28"},"PeriodicalIF":23.9,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell stem cellPub Date : 2026-01-03DOI: 10.1016/j.stem.2025.12.019
Nathalie Saurat, Andrew P. Minotti, Maliha T. Rahman, Trisha Sikder, Chao Zhang, Daniela Cornacchia, Johannes Jungverdorben, Gabriele Ciceri, Doron Betel, Lorenz Studer
{"title":"Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration","authors":"Nathalie Saurat, Andrew P. Minotti, Maliha T. Rahman, Trisha Sikder, Chao Zhang, Daniela Cornacchia, Johannes Jungverdorben, Gabriele Ciceri, Doron Betel, Lorenz Studer","doi":"10.1016/j.stem.2025.12.019","DOIUrl":"https://doi.org/10.1016/j.stem.2025.12.019","url":null,"abstract":"","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"24 1","pages":""},"PeriodicalIF":23.9,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145894478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell stem cellPub Date : 2025-12-22DOI: 10.1016/j.stem.2025.12.001
Madison R Glass,Nana Matoba,Alvaro A Beltran,Niyanta K Patel,Tala M Farah,Karthik Eswar,Shivam Bhargava,Karen Huang,Ian Curtin,Sara Ahmed,Mary Srivastava,Emma Drake,Liam T Davis,Meghana Yeturi,Kexin Sun,Michael I Love,Jeremy M Simon,Tanya St John,Natasha Marrus,Juhi Pandey,Annette Estes,Stephen Dager,Robert T Schultz,Kelly Botteron,Alan Evans,Sun Hyung Kim,Martin Styner,Robert C McKinstry,D Louis Collins,Heather Volk,Kelly Benke,Lonnie Zwaigenbaum,Heather Hazlett,Adriana S Beltran,Jessica B Girault,Mark D Shen,Joseph Piven,Jason L Stein,
{"title":"Human cortical organoids recapitulate inter-individual variability in infant brain-growth trajectories.","authors":"Madison R Glass,Nana Matoba,Alvaro A Beltran,Niyanta K Patel,Tala M Farah,Karthik Eswar,Shivam Bhargava,Karen Huang,Ian Curtin,Sara Ahmed,Mary Srivastava,Emma Drake,Liam T Davis,Meghana Yeturi,Kexin Sun,Michael I Love,Jeremy M Simon,Tanya St John,Natasha Marrus,Juhi Pandey,Annette Estes,Stephen Dager,Robert T Schultz,Kelly Botteron,Alan Evans,Sun Hyung Kim,Martin Styner,Robert C McKinstry,D Louis Collins,Heather Volk,Kelly Benke,Lonnie Zwaigenbaum,Heather Hazlett,Adriana S Beltran,Jessica B Girault,Mark D Shen,Joseph Piven,Jason L Stein, ","doi":"10.1016/j.stem.2025.12.001","DOIUrl":"https://doi.org/10.1016/j.stem.2025.12.001","url":null,"abstract":"Induced pluripotent stem cell (iPSC)-derived human cortical organoids (hCOs) model neurogenesis on an individual's genetic background. The degree to which hCO phenotypes recapitulate the brain growth of the participants from whom they were derived is not well established. We generated up to 3 iPSC clones from each of 18 participants in the Infant Brain Imaging Study, who underwent longitudinal brain imaging during infancy. We identified consistent hCO morphology and cortical cell types across clones from the same participant. hCO cross-sectional area and production of hem/choroid plexus were associated with in vivo cortical growth rates. Cell-cycle-associated gene expression in early progenitors at the crux of fate-decision trajectories was correlated with cortical growth rates from 6 to 12 months of age and was enriched for microcephaly and neurodevelopmental disorder genes. Our data suggest the hCOs capture inter-individual variation in cortical cell types that influences infant cortical surface area expansion.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"45 1","pages":""},"PeriodicalIF":23.9,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145813558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Human PSC-derived organoids model sympathetic ganglion development and its functional crosstalk with the heart","authors":"Yantong Liu, Jinkui Zhu, Xiaoxiang Lu, Xuran Zhuang, Jianfeng Wei, Linlin Jiang, Wei Zhou, Wei Pang, Yao Yin, Ziling Chen, Yajing Cao, Qinzhi Zhang, Sisi Chen, Siyuan Chu, Xinrui Zhang, Yangfei Xiang","doi":"10.1016/j.stem.2025.11.003","DOIUrl":"https://doi.org/10.1016/j.stem.2025.11.003","url":null,"abstract":"The sympathetic ganglia are essential components of the nervous system that regulate various aspects of involuntary body functions. Recapitulating sympathetic ganglion development with three-dimensional (3D) organoids is challenging and has not been achieved. Here, we report a method to differentiate human pluripotent stem cells into 3D neural organoids that resemble peripheral sympathetic ganglia, producing both neurons and glial cells of the ganglia in a self-organized manner. We developed an organoid system to construct functional connections between the sympathetic ganglia and one of their peripheral targets, the heart, by fusing human sympathetic ganglion organoids (hSGOs) and heart-forming organoids. Notably, this system enables the evaluation of signaling controls (i.e., nerve growth factor [NGF] signaling) on human sympathetic-to-cardiac innervation and reveals the reciprocal impacts between the sympathetic and cardiac lineages during their co-development. Our study provides a physiologically relevant platform for understanding the development of human sympathetic ganglia, their crosstalk with peripheral targets, and related diseases.","PeriodicalId":9665,"journal":{"name":"Cell stem cell","volume":"29 1","pages":""},"PeriodicalIF":23.9,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145732400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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