Stripe out for brain evolution: Astrocytes go human

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-03-06 DOI:10.1016/j.stem.2025.02.008

Lara López-González, Víctor Borrell

引用次数: 0

Abstract

Evolution of the human brain involved neuron and glial cell changes. In this issue of Cell Stem Cell, Ciuba et al.¹ identify an epigenetic mechanism central in the evolution of human astrocytes, where small enhancer modifications increased transcription factor binding, orchestrating transcriptomic changes that influence astrocyte structure and function.

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大脑进化：星形胶质细胞走向人类

人类大脑的进化涉及神经元和神经胶质细胞的变化。在这一期的《细胞干细胞》中，Ciuba等人发现了人类星形胶质细胞进化的一种重要的表观遗传机制，其中小的增强子修饰增加了转录因子的结合，协调了影响星形胶质细胞结构和功能的转录组变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.