Beyond transplantation: Gene-edited pig liver supports function in a human host

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-07-03 DOI:10.1016/j.stem.2025.06.005

Hidetaka Hara, Yi Wang

引用次数: 0

Abstract

A recent study in Nature demonstrates that a gene-edited pig liver can function in a brain-dead human for short-term support. This highlights the potential of xenogeneic liver transplantation as bridge therapy and opens new directions in regenerative medicine and cross-species organ engineering.

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超越移植：基因编辑的猪肝支持人类宿主的功能

最近发表在《自然》杂志上的一项研究表明，基因编辑的猪肝可以在脑死亡的人身上短期发挥作用。这突出了异种肝移植作为桥梁治疗的潜力，为再生医学和跨物种器官工程开辟了新的方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.