From symbiote to bad neighbor: The intestinal microbiome as a driver of CHIP

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-07-03 DOI:10.1016/j.stem.2025.06.003

Courtney M. Cowan, Eric M. Pietras

引用次数: 0

Abstract

Hematopoietic stem cells (HSCs) with mutations that can cause clonal hematopoiesis of indeterminate potential (CHIP) accumulate during aging. Agarwal et al.¹ demonstrate in Nature that intestinal barrier permeability increases with age and enables the microbial metabolite ADP-heptose to reach the bone marrow, thus driving the expansion of DNMT3A-mutant HSCs.

查看原文本刊更多论文

从共生体到坏邻居：肠道微生物组作为CHIP的驱动因素

具有突变的造血干细胞（hsc）可导致不确定潜力的克隆造血（CHIP）在衰老过程中积累。Agarwal等人1在Nature杂志上证实，肠道屏障通透性随着年龄的增长而增加，使微生物代谢物adp -庚糖能够到达骨髓，从而驱动dnmt3a突变型造血干细胞的扩增。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.