革命性的胰岛移植与预处理促进β细胞存活

IF 20.4 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-08-07 DOI:10.1016/j.stem.2025.06.011

Kewen Hu, Yajie Chen, Zhen Zhang

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引用次数: 0

摘要

胰岛移植后存活率低仍然是1型糖尿病（T1DM）治疗的一个重大挑战。Vandana等人1开发了ChemPerturb-seq，该技术与体内条形码筛选相结合，可识别可增强移植后人类β细胞和胰岛存活的小分子鸡尾酒，为治疗T1DM提供了有希望的策略。

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Revolutionizing islet transplantation with a preconditioning boost for beta cell survival

The poor survival of islets post-transplantation remains a significant challenge for type 1 diabetes mellitus (T1DM) therapy. Vandana et al.¹ develop ChemPerturb-seq, which is integrated with in vivo barcoded screening to identify small molecule cocktails that enhance human beta cell and islet survival after transplantation, offering promising strategies for T1DM.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.