类血管器官的再生修复速度加快

IF 20.4 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-08-07 DOI:10.1016/j.stem.2025.07.002

Danielle Klinger, Jeffrey A. Naftaly, Kristy Red-Horse

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引用次数: 0

摘要

Gong等人提出了一种转录因子引导的3D分化方法，可以从人iPSCs中快速生成类血管器官，增强小鼠模型中缺血肢体和移植胰岛的植入和血管重建这种方法为生成功能性血管系统建立了一个可扩展的平台，支持疾病建模和再生治疗的发展。

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查看原文本刊更多论文

Vascular organoids get a speed boost for regenerative repair

Gong et al. present a transcription factor-guided 3D differentiation that rapidly generates vascular organoids from human iPSCs, enhancing engraftment and revascularization of ischemic limbs and transplanted pancreatic islets in mouse models.¹ This approach establishes a scalable platform for generating functional vasculature, supporting both disease modeling and regenerative therapy development.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.