剧情转折：TET2克隆人拯救了大脑

IF 20.4 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-08-07 DOI:10.1016/j.stem.2025.07.001

Maria A. Telpoukhovskaia, Jennifer J. Trowbridge

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引用次数: 0

摘要

虽然克隆造血（CH）与预防阿尔茨海默病（AD）有关，但对其发生机制的有限理解一直是治疗干预的障碍。在一项新的研究中，Matatall等人发现了tet2突变体（而非dnmt3a突变体）影响痴呆病理和认知的保护机制。

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Plot twist: TET2 clones save the brain

While clonal hematopoiesis (CH) is associated with protection from Alzheimer’s disease (AD), a limited understanding of the mechanisms by which this occurs has been a barrier to therapeutic intervention. In a new study, Matatall et al.¹ discover protective mechanisms by which TET2-mutant, but not DNMT3A-mutant, CH impacts dementia pathology and cognition.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.