Case Reports in Gastroenterology最新文献_第7页

Peroral Endoscopic Tumor Resection for Esophageal Leiomyoma with Accumulation of Fluorine-18-Fluorodeoxyglucose: A Case Report. 经口内镜切除伴氟-18-氟脱氧葡萄糖积累的食管平滑肌瘤1例

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-03-12 eCollection Date: 2025-01-01 DOI: 10.1159/000543564

Takayuki Sawa, Osamu Dohi, Naoto Iwai, Katsuma Yamauchi, Mayuko Seya, Hajime Miyazaki, Hayato Fukui, Hiroaki Kitae, Tsugitaka Ishida, Yoshito Itoh

{"title":"Peroral Endoscopic Tumor Resection for Esophageal Leiomyoma with Accumulation of Fluorine-18-Fluorodeoxyglucose: A Case Report.","authors":"Takayuki Sawa, Osamu Dohi, Naoto Iwai, Katsuma Yamauchi, Mayuko Seya, Hajime Miyazaki, Hayato Fukui, Hiroaki Kitae, Tsugitaka Ishida, Yoshito Itoh","doi":"10.1159/000543564","DOIUrl":"10.1159/000543564","url":null,"abstract":"Introduction: Esophageal leiomyomas are relatively common benign esophageal submucosal tumors (SMTs). Generally, benign tumors do not accumulate fluorine-18-fluorodeoxyglucose (FDG), but it is not rare for FDG to accumulate in uterine, duodenal, or esophageal leiomyomas. In our case, we performed peroral endoscopic tumor resection (POET) for an esophageal leiomyoma with FDG accumulation.Case presentation: A 40-year-old female with a history of surgery for right breast cancer underwent fluorine-18-fluorodeoxyglucose-positron emission tomography for surveillance examination and had no specific symptoms or notable clinical findings. A subepithelial tumor with intense FDG uptake (SUVmax, 5.49) was detected in the middle thoracic esophagus. The lesion appeared as a low-absorption area on contrast-enhanced CT and was confirmed to have an equivalent signal level as muscle tissue on MRI T2WI. Endoscopic examination revealed SMT 25 cm from the incisors. Endoscopic ultrasonography (EUS) revealed a 20 mm low-luminance mass, mainly located in the second and third layers. The histopathology diagnosis by EUS-fine-needle aspiration was leiomyoma. We decided to treat it with POET because malignancy could not be ruled out. The tumor was excised en bloc using POET without severe complications. The tumor diameter was 19 × 15 mm, and disordered spindle cells were observed. Desmin and αSMA were positive, and S100 protein was negative on immunohistochemical study. Therefore, the pathological diagnosis was a leiomyoma.Conclusion: In the present case, glucose transporter 1 expression was negative; however, we examined why the leiomyoma accumulated FDG. We suggest that awareness of leiomyoma with the accumulation of FDG exists in clinical practice.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"19 1","pages":"146-152"},"PeriodicalIF":0.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Turmeric-Induced Hepatotoxicity with Hyperferritinemia. 姜黄致肝毒性伴高铁蛋白血症1例。

IF 0.6

Case Reports in Gastroenterology Pub Date : 2025-03-10 eCollection Date: 2025-01-01 DOI: 10.1159/000543842

Nina R Spitofsky, Albert A Huang, Aria Jalalian, Stefanie Gallagher, Scott Fink

{"title":"A Case of Turmeric-Induced Hepatotoxicity with Hyperferritinemia.","authors":"Nina R Spitofsky, Albert A Huang, Aria Jalalian, Stefanie Gallagher, Scott Fink","doi":"10.1159/000543842","DOIUrl":"10.1159/000543842","url":null,"abstract":"Introduction: We present the first published case of turmeric-associated drug-induced liver injury (DILI) accompanied by significant ferritin elevation.Case presentation: Our patient, a 59-year-old female with DILI caused by long-term ingestion of oral turmeric supplements, presented with painless jaundice on an annual exam. The patient's liver function tests exhibited a hepatocellular pattern and hyperferritinemia (>2,000 ng/dL). Additional testing was negative except for heterozygosity for the H63D allele associated with hemochromatosis. A liver biopsy indicated acute hepatitis without fibrosis or stainable iron.Conclusion: Upon discontinuation of the supplement, liver enzymes normalized within a month. This case highlights the potential for hepatotoxicity and hyperferritinemia from curcumin toxicity, particularly when combined with additives like black pepper that enhance its bioavailability. Awareness of this phenomenon, particularly in heterozygous carriers of hemochromatosis, is crucial for diagnosis and optimal management.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"19 1","pages":"140-145"},"PeriodicalIF":0.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Pneumothorax in a Pediatric Patient with Crohn's Disease Receiving Ustekinumab Treatment: Case Report. 接受乌斯特金单抗治疗的克罗恩病儿童患者复发性气胸：病例报告

IF 0.6

Case Reports in Gastroenterology Pub Date : 2025-03-05 eCollection Date: 2025-01-01 DOI: 10.1159/000543991

Marta Freixas Bermejo, Luis Riera Soler, Laura García Martínez, Oscar Segarra Cantón

引用次数: 0

A Rare Case Report of Colonic Pseudolipomatosis with Distinct Endoscopic and Histological Features. 具有明显内镜及组织学特征的结肠假性脂肪瘤病1例报告。

IF 0.6

Case Reports in Gastroenterology Pub Date : 2025-02-27 eCollection Date: 2025-01-01 DOI: 10.1159/000543951

Qi Zhao, Hai-Tao Yu, Qun-Ying Wang, Wei Zhang, Wen-Zhu Dong

{"title":"A Rare Case Report of Colonic Pseudolipomatosis with Distinct Endoscopic and Histological Features.","authors":"Qi Zhao, Hai-Tao Yu, Qun-Ying Wang, Wei Zhang, Wen-Zhu Dong","doi":"10.1159/000543951","DOIUrl":"10.1159/000543951","url":null,"abstract":"Introduction: Colonic pseudolipomatosis is a rare benign lesion with distinct endoscopic and histological features. The etiology and pathogenesis of colonic pseudolipomatosis have not been fully clarified and are still controversial to some extent. It is particularly noteworthy that this lesion must be differentiated from real pathological entities to avoid further unnecessary auxiliary examinations and overtreatments.Case presentation: We report a case of a 61-year-old woman who underwent regular postoperative follow-ups of rectal cancer. The colonoscopy showed multiple slightly elevated whitish plaques with irregular shapes in almost all of the colon. The plaques were biopsied to further define the focal nature. Further histopathological examination revealed numerous scattered or clustered adipocyte-like vacuoles in lamina propria. Immunohistochemistry results were negative for anti-CD34 and anti-protein S-100, supporting the diagnosis of pseudolipomatosis.Conclusion: Colonic pseudolipomatosis is a rare and benign self-limiting condition that should not be mistaken for a pathological entity, especially active inflammation or malignant tumor. Endoscopic lesions commonly regress spontaneously without complications and appropriate management is necessary because it requires no further investigations or treatments.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"19 1","pages":"127-133"},"PeriodicalIF":0.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aseptic Abscess Syndrome: A Case Report of a Rare Extraintestinal Manifestation of Inflammatory Bowel Disease. 无菌性脓肿综合征：一例罕见的炎症性肠病肠外表现。

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-02-27 eCollection Date: 2025-01-01 DOI: 10.1159/000543761

Clive Jude Miranda, Nariman Hossein-Javaheri, Gina Marie Sparacino, Yousef Soofi, Farhan Azad, Nikki Duong

引用次数: 0

Effectiveness of Triamcinolone Injections in Preventing Scar Deformity following Endoscopic Submucosal Dissection for Pharyngeal Cancer. 曲安奈德注射预防咽癌内镜下粘膜下剥离术后瘢痕畸形的疗效。

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.1159/000543878

Yugo Suzuki, Shinji Ito, Tsuyoshi Ishii, Minoru Oda, Shu Hoteya

{"title":"Effectiveness of Triamcinolone Injections in Preventing Scar Deformity following Endoscopic Submucosal Dissection for Pharyngeal Cancer.","authors":"Yugo Suzuki, Shinji Ito, Tsuyoshi Ishii, Minoru Oda, Shu Hoteya","doi":"10.1159/000543878","DOIUrl":"https://doi.org/10.1159/000543878","url":null,"abstract":"Introduction: Endoscopic submucosal dissection (ESD) is an effective treatment for superficial pharyngeal cancer. However, pharyngeal deformity caused by postoperative ulcer contraction is a major concern and can result in a poor quality of life. While local steroid injections have been shown to prevent strictures after ESD for esophageal cancer, their effectiveness in preventing deformities following ESD for pharyngeal cancer remains unclear.Case presentation: A 60-year-old woman with superficial pharyngeal cancer in the left pyriform sinus underwent ESD. After ESD, 80 mg of triamcinolone acetonide was injected into the ulcer bed to prevent scar contracture. The patient experienced mild pharyngeal pain, which resolved within a few days. Histopathological examination confirmed the lesion was well-differentiated SCC, with negative resection margins and no lymphovascular invasion. Follow-up endoscopy at 6 weeks showed granulation tissue in the surgical wound, which completely healed without pharyngeal deformity by 14 weeks post-ESD.Conclusion: This case demonstrated that the injection of triamcinolone in an ulcer that developed after ESD may be an effective method of preventing pharyngeal deformity caused by scar contracture.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"19 1","pages":"113-119"},"PeriodicalIF":0.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11857159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Intra-Abdominal Desmoid Tumor with Edematous Loose Collagen Fibers. 腹内硬纤维瘤伴疏松胶原纤维水肿。

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.1159/000543498

Mao Iino, Shoji Oura

{"title":"An Intra-Abdominal Desmoid Tumor with Edematous Loose Collagen Fibers.","authors":"Mao Iino, Shoji Oura","doi":"10.1159/000543498","DOIUrl":"10.1159/000543498","url":null,"abstract":"Introduction: Diagnostic physicians tend to judge a low-dense area on computed tomography (CT) as central necrosis when it has no contrast enhancement and locates in the center of large tumors.Case presentation: An 80-year-old woman was referred to our hospital due to the detection of an abdominal mass on ultrasound (US). CT showed a well-demarcated oval mass, 11 cm in size, with a central low-density area. US showed high internal echoes and enhanced posterior echoes. Magnetic resonance imaging (MRI) showed the low-density area on CT to be hypo-intense on T1-weighted images and hyper-intense on T2-weighted images. MRI further showed the central part of the tumor to be hyper-intense both on diffusion-weighted images and apparent diffusion coefficient images. Under the tentative diagnosis of a gastrointestinal stromal tumor with central necrosis, the patient underwent tumor resection, revealing the tumor to be a jejunal submucosal tumor. Pathological study showed collagen fibers with heterogeneous density and sparse proliferation of spindle cells. The center of the tumor had marked edema in addition to sparse collagen fibers. Immunostaining showed that the atypical cells were diffusely positive for β catenin and negative for S100 protein, desmin, and DOG1, leading to the diagnosis of desmoid tumor (DT).Conclusions: Physicians should note that intra-abdominal DT can have edematous loose collagen fibers and may show central necrosis-like findings on CT.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"19 1","pages":"107-112"},"PeriodicalIF":0.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11857155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-Induced Liver Injury Associated with Turmeric and Piperine: A Case and Review. 姜黄和胡椒碱相关的药物性肝损伤：一个病例和回顾。

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-02-24 eCollection Date: 2025-01-01 DOI: 10.1159/000543679

Atul Shrestha, Sarah Elliott, Joshua Haron Abasszade, Kyle Wu, Thomas Worland, Ian Simpson, Anouk Dev

{"title":"Drug-Induced Liver Injury Associated with Turmeric and Piperine: A Case and Review.","authors":"Atul Shrestha, Sarah Elliott, Joshua Haron Abasszade, Kyle Wu, Thomas Worland, Ian Simpson, Anouk Dev","doi":"10.1159/000543679","DOIUrl":"10.1159/000543679","url":null,"abstract":"Introduction: Turmeric is a common spice used in traditional Chinese and Ayurvedic medicine for a variety of purported health benefits. Recent concerns have arisen regarding turmeric-induced liver injury linked to formulations with enhanced bioavailability, often including piperine found in black pepper.Case presentation: We explore a case of a 40-year-old female with increasing fatigue, pruritus, and dark urine following consumption of turmeric and black pepper \"wellness shots\" leading to a significant drug-induced liver injury.Conclusion: This case underscores the critical need to recognise herbal remedies, such as turmeric, as potential sources of hepatotoxicity. Despite a reputation of safety, limited regulation and testing of turmeric may mean potential adverse effects are under-recognised. Understanding the mechanisms behind turmeric and black pepper's hepatotoxicity, including the role of potential genetic predispositions, requires further investigation for its safe use.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"19 1","pages":"96-106"},"PeriodicalIF":0.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory Bowel Disease in a Patient Returning from Colombia: Association with Dipeptidyl Peptidase 4 Inhibitor? 从哥伦比亚回来的炎症性肠病患者：与二肽基肽酶4抑制剂有关？

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-02-21 eCollection Date: 2025-01-01 DOI: 10.1159/000543680

Ahmed B Bayoumy, Gwen M C Masclee, Nanne K H de Boer, Andra Neefjes-Borst, Dirk Jan Stenvers

{"title":"Inflammatory Bowel Disease in a Patient Returning from Colombia: Association with Dipeptidyl Peptidase 4 Inhibitor?","authors":"Ahmed B Bayoumy, Gwen M C Masclee, Nanne K H de Boer, Andra Neefjes-Borst, Dirk Jan Stenvers","doi":"10.1159/000543680","DOIUrl":"10.1159/000543680","url":null,"abstract":"Introduction: Recent-onset colitis poses a diagnostic challenge, necessitating a thorough evaluation to identify potential infectious and non-infectious etiologies. We considered inflammatory bowel disease (IBD) secondary to dipeptidyl peptidase 4 (DPP-4) inhibitor-induced colitis.Case presentation: This case report details the presentation and management of a patient with persistent dysentery, refractory to conventional treatments, ultimately attributed to IBD possibly secondary to long-term DPP-4 inhibitor use. Following an episode of suspected amebiasis, the patient experienced prolonged bloody diarrhea with an endoscopic image compatible with ulcerative colitis. Extensive infectious diagnostics were negative. Ultimately, the cessation of sitagliptin therapy resulted in rapid symptom resolution and normalization of eosinophilia, as well as endoscopic improvement. However, after a few weeks, the patient was readmitted with diarrhea after continued cessation of sitagliptin.Conclusion: This case underscores the importance of considering IBD secondary to DPP-4 inhibitor use in the evaluation of patients with recent-onset IBD. Further research is needed to elucidate the pathophysiological mechanisms underlying the relationship between DPP-4 inhibitors and IBD.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"19 1","pages":"89-95"},"PeriodicalIF":0.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe Acute Pancreatitis Complicated by Multiple Intra-Abdominal Hemorrhages. 重症急性胰腺炎并发多发性腹腔出血。

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-02-19 eCollection Date: 2025-01-01 DOI: 10.1159/000543626

Cong-Yu Wang, Yin Gu, Rui-Peng Yan, Xin Li, Fei He, Xiang-Lan Feng, Gen Zhang, Yun-Feng Cui

{"title":"Severe Acute Pancreatitis Complicated by Multiple Intra-Abdominal Hemorrhages.","authors":"Cong-Yu Wang, Yin Gu, Rui-Peng Yan, Xin Li, Fei He, Xiang-Lan Feng, Gen Zhang, Yun-Feng Cui","doi":"10.1159/000543626","DOIUrl":"10.1159/000543626","url":null,"abstract":"Introduction: Intra-abdominal hemorrhage is a rare yet life-threatening complication of acute pancreatitis (AP), with a higher prevalence in cases of severe acute pancreatitis (SAP). This condition is primarily caused by vessel wall erosion and rupture of pseudoaneurysms (PSAs). However, SAP cases involving multiple sequential arterial hemorrhages are extremely rare. This condition is primarily brought on by the process of vessel wall degeneration and the development of PSAs. Nonetheless, SAP necessitating multiple episodes of arterial bleeding is very uncommon.Case presentation: Here is the case history of a 31-year-old man already being treated for SAP. His condition was then complicated by massive, frequent intra-abdominal bleeding. The patient initially presented to the hospital with SAP. He was transferred to the intensive care unit for proper management. Massive intra-abdominal bleeds occurred on the 31st, 45th, and 60th days during hospitalization. The maximum blood loss was 1,500 mL. In each of the instances, digital subtraction angiography (DSA) embolization was carried out after the bleeding source had been verified. In order to manage SAP, continuous percutaneous drainage and staged pancreatic necrosectomy were undertaken for 6 months. No recurrence of intra-abdominal hemorrhage was detected. Infection of the abdominal cavity was properly controlled. The patient left the hospital in good condition.Conclusion: Spontaneous bleeding in the abdominal cavity is a severe and life-threatening complication of SAP. This is often caused by vessel wall erosion. In such cases, DSA plays a crucial role in diagnosis and management. Besides precisely locating the bleeding source, one can perform a much-needed embolization immediately. Consequently, the disease is under total control, and the patient is much more likely to survive.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"19 1","pages":"79-88"},"PeriodicalIF":0.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0