Case Reports in Gastroenterology最新文献

{"title":"Hyperammonemia after Liver Surgery: A Case Report of an Unanticipated Postoperative Challenge.","authors":"Dan Koning, Nathanja Schep, Jeroen Hagendoorn, Jelmer Oor, Maaike A Sikma","doi":"10.1159/000552943","DOIUrl":"10.1159/000552943","url":null,"abstract":"<p><strong>Introduction: </strong>Hepatic encephalopathy after liver surgery is an uncommon but serious complication.</p><p><strong>Case presentation: </strong>We describe an unusual case of a patient with a history of uretero-sigmoidostomy who developed severe hepatic encephalopathy following hepatectomy for liver metastases of colorectal cancer. Mechanical ventilation, ammonia-lowering drugs and continuous veno-venous hemofiltration were required in order to reverse encephalopathy. As ammonia production is principally governed via hydrolysis of urea in the gut, it is hypothesized that ammonia reabsorption via the uretero-sigmoidostomy played a pivotal role in the clinical course of this patient.</p><p><strong>Conclusion: </strong>This report highlights the need for awareness for reabsorption of ammonia in case of a uretero-sigmoidostomy in order to avoid unnecessary complications.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"252-257"},"PeriodicalIF":0.7,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13391080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticoagulation-Amplified Recurrent Esophageal Hemorrhage in Triple-Positive Antiphospholipid Syndrome: The Inescapable Anticoagulation Dilemma.","authors":"Akram Alnounou, Chelsea Zambrano, Arghyadeep Ganguly, Harry Boamah","doi":"10.1159/000552878","DOIUrl":"10.1159/000552878","url":null,"abstract":"<p><strong>Introduction: </strong>Antiphospholipid syndrome (APS) is an acquired thrombophilia. Triple-positive APS, defined by lupus anticoagulant, anticardiolipin, and anti-β2-glycoprotein I antibody positivity, usually requires long-term vitamin K antagonist therapy; direct oral anticoagulants are discouraged, and low-molecular-weight heparin is reserved for selected situations.</p><p><strong>Case presentation: </strong>A 52-year-old female with systemic lupus erythematosus and triple-positive APS on warfarin (International Normalized Ratio [INR] 2.9) presented with massive hematemesis requiring intubation. Serial esophagogastroduodenoscopy showed extensive esophageal clot burden followed by circumferential friability, sloughing, and necrotic/exudative esophagitis without varices or gastric/duodenal bleeding. Hemostatic powder was applied, fresh frozen plasma partially corrected the INR to 1.8, and anticoagulation was held. Therapeutic heparin bridging on hospital day 8 was followed by recurrent melena, hemoglobin decline from 8.3 to 5.5 g/dL, and gross hematuria; INR at rebleeding was 2.2. Hematology evaluation showed factor VIII activity 87% and negative Bethesda assay, arguing against acquired hemophilia A. Repeat endoscopy showed Los Angeles grade C esophagitis with clean-based linear ulcers and a 7-cm sliding hiatal hernia.</p><p><strong>Conclusion: </strong>Severe diffuse esophageal mucosal injury can cause recurrent major bleeding when anticoagulation is resumed before mucosal recovery. In high-risk APS, anticoagulation resumption should be individualized with hematology and gastroenterology input, and repeat endoscopy may help guide timing.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"266-275"},"PeriodicalIF":0.7,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Ultrasound-Guided Gastrojejunostomy for Efferent Limb Syndrome and Benign Gastric Outlet Obstruction in a Patient with Whipple Anatomy: A Case Report.","authors":"Toni Habib, Malek Kreidieh, Vishnu Kumar, Hassan Al Moussawi, Youssef El Douaihy, Sherif Andrawes, Jean M Chalhoub","doi":"10.1159/000552316","DOIUrl":"10.1159/000552316","url":null,"abstract":"<p><strong>Introduction: </strong>Lumen-apposing metal stents (LAMSs) have emerged as a versatile tool for managing various gastrointestinal conditions, including postsurgical complications. This case report describes the successful use of endoscopic ultrasound-guided gastrojejunostomy (EUS-GJ) with LAMS placement to treat efferent limb syndrome (ELS) causing gastric outlet obstruction (GOO) in a patient with altered anatomy after a Whipple procedure.</p><p><strong>Case presentation: </strong>An 83-year-old female with a history of pancreatic adenocarcinoma status post-Whipple procedure presented with symptoms of GOO 1 year after surgery. Imaging and endoscopy revealed acute angulation at the efferent limb takeoff resulting in mechanical obstruction of the gastrojejunal anastomosis (GJ) without evidence of malignancy. The patient was also found to have ascites concerning for a recurrent pancreatic malignancy. Due to the patient's age and poor surgical candidacy, an EUS-GJ was successfully performed using a 20 × 10 mm cautery-enhanced LAMS bypassing the obstruction in the efferent limb and resulting in immediate symptom relief. The patient gained weight after 1 month of follow-up and remained clinically well with no procedural related complications after a 30-day follow-up.</p><p><strong>Conclusion: </strong>This case highlights the potential of EUS-GJ as an effective, minimally invasive technique for managing complex postsurgical complications in patients with altered anatomy. The technique provided symptom relief while minimizing morbidity and recovery time. In patients with disease progression, EUS-GJ should be considered for the palliation of GOO caused by ELS on a case-by-case basis after discussion between the endoscopists and surgeons.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"246-251"},"PeriodicalIF":0.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13363138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148435105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report of an Asymptomatic Cecum Ulceration Colonoscopically and Radiologically Mimicking Inflammatory Bowel Disease Caused by Amebic Colitis.","authors":"Xinyuan Huang, Bing Yue, Fujing Lv, Qiaozhi Zhou","doi":"10.1159/000552574","DOIUrl":"10.1159/000552574","url":null,"abstract":"<p><strong>Introduction: </strong>Amebiasis is a disease caused by the protozoan parasite <i>Entamoeba histolytica</i> (Eh) and remains the second leading cause of death due to parasitic infections worldwide. Asymptomatic Eh infections are the most common. Infection with Eh can transition from a harmless colonic colonizer to a pathogenic form, leading to amebic colitis. The clinical presentation of amebic colitis is varied and may include abdominal pain, bloody-mucoid diarrhea, tenesmus, and low-grade fever. These symptoms are often nonspecific and can mimic many other gastrointestinal conditions, both infectious and noninfectious.</p><p><strong>Case presentation: </strong>We report a case of amebic colitis in a 62-year-old male who underwent routine colonoscopy, which revealed an ulceration in the cecum region. He was asymptomatic at presentation and had normal laboratory findings. The case was provisionally diagnosed as inflammatory bowel disease and received oral metronidazole and probiotics. At follow-up endoscopy, the ulceration had worsened. Biopsy from the margin of the ileocecal ulcer confirmed abundant amebic trophozoites. The patient was treated with metronidazole for 14 days. A follow-up colonoscopy after treatment showed that the lesions were completely healed.</p><p><strong>Conclusion: </strong>This case highlights the challenges of diagnosing amebic colitis. Amoebic colitis shows significant variation in presenting symptoms, and current diagnostic methods have limited sensitivity. The absence of obvious symptoms in this patient further increased the diagnostic difficulty. We recommend that clinicians consider invasive amebiasis in their list of differential diagnosis even in asymptomatic patients presenting with colonic ulceration.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"258-265"},"PeriodicalIF":0.7,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dobhoff Detour: A Case Report of Unintended Biliary Cannulation and Persistent Pneumobilia after Passage of a Nasogastric Feeding Tube.","authors":"Victoria A Margolis, Abigail L Ellington, Elizabeth M Armstrong, Collin H York, John M Provenza, Richard B Weinberg","doi":"10.1159/000552548","DOIUrl":"10.1159/000552548","url":null,"abstract":"<p><strong>Introduction: </strong>Dobhoff tubes are small, flexible feeding tubes commonly used for enteral nutrition in critically ill patients. Although misplacement is known to occur, to our knowledge, direct displacement into the biliary tree has not previously been reported.</p><p><strong>Case presentation: </strong>We present a case report of a patient with pneumobilia and a duodenal diverticulum noted on CT imaging at admission. After Dobhoff tube placement, an abdominal radiograph suggested a peripyloric position; however, subsequent CT imaging revealed direct cannulation of the common bile duct with termination in the right hepatic duct. This malpositioning was associated with worsening pneumobilia and prompted immediate correction of the tube position. The pneumobilia persisted but gradually decreased over time.</p><p><strong>Conclusion: </strong>We believe that the patient's duodenal diverticulum created an anatomic pathway that enabled the tube to enter the biliary system. To our knowledge, this is the first reported case of direct biliary cannulation by a nasoenteric feeding tube and underscores the importance of cross-sectional imaging when malposition is suspected.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"226-232"},"PeriodicalIF":0.7,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13345614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Necrotizing Pancreatitis and Endovascular Stenting of the Portal and Superior Mesenteric Vein: A Case Report.","authors":"Lars J M de Lange, Hanne C R Verberght, Thomas J G R De Clercq, Ulf P Neumann, Maxime J L Dewulf, Marcel C G van de Poll, Steven W M Olde Damink, Jan-Werner Poley, Sanne W de Boer, Stefan A W Bouwense","doi":"10.1159/000552618","DOIUrl":"10.1159/000552618","url":null,"abstract":"<p><strong>Introduction: </strong>Venous and arterial thrombosis are severe (vascular) complications of acute pancreatitis. They are commonly associated with necrotizing pancreatitis and are a major cause of mortality. Venous thrombosis, most frequently involving the splenic, portal or superior mesenteric veins (SMVs), occurs due to local inflammation, compression, or endothelial injury.</p><p><strong>Case presentation: </strong>We present the case of a 35-year-old male that was admitted to the intensive care unit of our academic hospital due to severe acute pancreatitis. The patient developed a retroperitoneal acute necrotic collection (ANC), which was retroperitoneally drained and finally debrided with a video-assisted retroperitoneal debridement (VARD). Besides development of the ANC, thrombosis of the portal vein (PV) and the superior mesenteric vein (SMV) developed. Post VARD procedure extensive venous bleedings occurred in the retroperitoneal cavity necessitating angiography which showed extensive venous collaterals due to the occlusion of the PV and SMV. Stenting of the SMV and PV was performed, after this procedure venous return was restored and the retroperitoneal bleeding stopped. Nearly 2 years after placement an occlusion of the stents was noted, and again variceal hemorrhage occurred necessitating relining of the stents.</p><p><strong>Conclusion: </strong>Treatment of diffuse venous collateral bleeding in the setting of acute pancreatitis associated with PV and SMV obstruction due to stenosis and/or thrombosis is complex and potentially lethal. This case illustrates that endovascular stenting of the portomesenteric veins can be an effective salvage strategy to decompress venous collaterals, restore venous outflow, and arrest life-threatening bleeding. Given the rarity and severity of this complication, robust data on indications, timing, long-term patency, rebleeding risk, and overall survival after portomesenteric stenting in acute pancreatitis are lacking, underscoring the need for systematic reporting and prospective studies to guide clinical decision-making in this high-risk population.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"233-239"},"PeriodicalIF":0.7,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13349370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenteric Hyperperfusion Syndrome following Endovascular Treatment of Chronic Mesenteric Ischemia: A Case Report.","authors":"Maksym Katelenets, Dmitry Shepovalov, George Greenberg","doi":"10.1159/000552573","DOIUrl":"10.1159/000552573","url":null,"abstract":"<p><strong>Introduction: </strong>Revascularization for chronic mesenteric ischemia is generally well tolerated, yet some patients experience acute multisystem deterioration afterward. The term reperfusion syndrome, commonly used in the context of acute ischemia, is often incorrectly applied to chronic disease.</p><p><strong>Case presentation: </strong>We present a case of hyperperfusion syndrome following successful two-vessel stenting in a patient with chronic mesenteric ischemia, complicated by ascites and supported by imaging and laboratory findings. Our report also highlights new-onset thrombocytopenia as part of the clinical picture. The syndrome resolved spontaneously with supportive care.</p><p><strong>Conclusion: </strong>Clinicians should remain alert to hyperperfusion phenomena in chronic cases, particularly after simultaneous two-vessel revascularization.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"240-245"},"PeriodicalIF":0.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13363139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148435121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Olmesartan-Induced Enteropathy Mimicking Amyloidosis in the Setting of New Multiple Myeloma Diagnosis.","authors":"Mohamad Mahdi Osman, Moises Salgado-de la Mora, Rishaan Sharma, Abdelwahab Ahmed, Sima Fansa, Talal Massad, Hussam Kawas, Mohamed El Hag, Vitaliy Rotenberg","doi":"10.1159/000552526","DOIUrl":"10.1159/000552526","url":null,"abstract":"<p><strong>Introduction: </strong>Olmesartan-induced enteropathy is an uncommon but important cause of severe chronic diarrhea and weight loss that can mimic celiac disease and infiltrative gastrointestinal disorders.</p><p><strong>Case presentation: </strong>We report a 71-year-old man on long-term olmesartan who presented with months of diarrhea, nausea/vomiting, profound weakness, and ∼100 pounds of unintentional weight loss. Esophagogastroduodenoscopy demonstrated duodenal villous blunting with lamina propria lymphoplasmacytic inflammation and rare periodic acid-Schiff-positive macrophages. An empiric 3-week gluten-free diet trial was ineffective. Celiac serologies, infectious stool studies, and HIV testing were negative. Laboratory evaluation revealed anemia, elevated creatinine, hypercalcemia, and a gamma gap; serum and urine protein electrophoresis showed an M-protein, and bone marrow biopsy confirmed multiple myeloma. Repeat duodenal biopsies again showed villous blunting, while Congo red staining was negative, arguing against gastrointestinal amyloidosis. Olmesartan-induced enteropathy was favored; olmesartan was discontinued and budesonide was started. Within 1 month, gastrointestinal symptoms resolved and the patient gained 20 pounds.</p><p><strong>Conclusion: </strong>Recognition of this drug effect is critical, particularly when concurrent hematologic disease raises concern for infiltrative etiologies.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"210-215"},"PeriodicalIF":0.7,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13341098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148403758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esophageal Stricture in a 5-Year-Old Child with Epidermolysis Bullosa: Case Report of a Rare Complication at a Very Young Age.","authors":"Onella Fernandes, Harshit Vachher, Adwait Bendre, Dhruvi Shah, Ira Shah","doi":"10.1159/000552413","DOIUrl":"10.1159/000552413","url":null,"abstract":"<p><strong>Introduction: </strong>Epidermolysis bullosa (EB) represents a group of rare inherited mechanobullous disorders characterized by extreme skin and mucosal fragility. Dystrophic EB (DEB), caused by mutations in the <i>COL7A1</i> gene, often leads to cycles of blistering, healing, and scarring with multisystem involvement, including the gastrointestinal tract. Esophageal strictures are not uncommon in recessive DEB (RDEB), appearing after the first decade of life (∼12.6 years). We describe a relatively early complication in a 5-year-old child.</p><p><strong>Case presentation: </strong>A 5-year-old girl with genetically confirmed RDEB presented with 4 months of progressive dysphagia, vomiting, and retrosternal pain, more pronounced with solids. Her disease history included severe skin fragility since birth, scarring, and autoamputation of toes. Examination showed multiple healed ulcers, mitten deformities of all limbs, dental caries, and bilateral corneal opacities. Laboratory evaluation revealed anemia (Hb 7.7 g/dL). Barium swallow demonstrated a short mid-esophageal stricture; upper gastrointestinal endoscopy confirmed focal narrowing at 14 cm from the incisors. Endoscopic balloon dilatation up to 8 mm using a controlled radial expansion was performed, and the patient was initiated on oral losartan (8 mg/day) to reduce transforming growth factors-β-mediated fibrosis and stricture recurrence. Serial dilatations were planned at 3-week intervals.</p><p><strong>Conclusion: </strong>This case represents one of the youngest reported presentations of esophageal stricture in RDEB. The combination of early endoscopic balloon dilatation and adjunct antifibrotic therapy with losartan may reduce recurrence and improve nutritional outcomes. Monitoring for early esophageal involvement in young patients with RDEB is essential for timely intervention.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"204-209"},"PeriodicalIF":0.7,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13341104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148403714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted Ileal Bile Acid Transporter Inhibition as Rescue Therapy for Tirzepatide-Induced Severe Constipation: A Case Report.","authors":"Bodhisatwa Choudhuri","doi":"10.1159/000552414","DOIUrl":"10.1159/000552414","url":null,"abstract":"<p><strong>Introduction: </strong>Constipation is a common, dose-dependent adverse effect of incretin-based anti-obesity therapies that affects patient adherence and may necessitate discontinuation, resulting in loss of metabolic benefits and weight regain. Elobixibat, an ileal bile acid transporter (IBAT) inhibitor, may offer a targeted alternative when conventional laxatives fail.</p><p><strong>Case presentation: </strong>A 56-year-old woman with obesity (95 kg; BMI 38.5 kg/m²) developed severe constipation after increasing tirzepatide to 10 mg weekly. Her bowel movements decreased from 6 to 8 times weekly (Bristol Stool Chart types 3-5) to 2-3 times weekly (types 1-2), with worst symptoms 2-3 days post-injection. Lactulose, psyllium, stimulant laxatives, and polyethylene glycol were ineffective or poorly tolerated, leading to painful perianal fissures. Tests showed hypertriglyceridemia and mild transaminitis with no obstruction on imaging. Elobixibat was started at 10 mg daily before dinner with continued tirzepatide. Bowel movement occurred 20 h after the administration. Stool frequency improved to 5-6 times weekly initially and 9-10 times weekly in the second week. Transient loose stools resolved after reducing elobixibat to 5 mg daily. By week three, bowel movements normalized to 7-8 times weekly (types 3-5) with improved defecation and resolved perianal symptoms. No serious adverse events were observed.</p><p><strong>Conclusion: </strong>Elobixibat provided effective relief, enabling the continuation of tirzepatide therapy. Therefore, a prospective evaluation is recommended. IBAT inhibition may represent a mechanism-based strategy to overcome the specific motility deficits induced by incretin therapy.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"216-225"},"PeriodicalIF":0.7,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13345612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}