Case Reports in Gastroenterology最新文献_第3页

Diarrhea, Weight Loss, and an Elevated Gastrin: A Case Report. 腹泻、体重减轻和胃泌素升高：1例报告。

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-06-11 eCollection Date: 2025-01-01 DOI: 10.1159/000545714

Ryan G Alexander, John C Cheville, Geoffrey B Thompson, Glenn L Alexander

{"title":"Diarrhea, Weight Loss, and an Elevated Gastrin: A Case Report.","authors":"Ryan G Alexander, John C Cheville, Geoffrey B Thompson, Glenn L Alexander","doi":"10.1159/000545714","DOIUrl":"10.1159/000545714","url":null,"abstract":"Introduction: Hypergastrinemia in a patient with refractory reflux, steatorrhea, or peptic ulcer disease with a gastric pH <4 is concerning for Zollinger-Ellison syndrome (ZES), but antral G-cell hyperplasia can also present in this manner and is distinguished from ZES based on negative radiographic studies and secretory stimulation testing with a typical gastrin response to a standardized test meal.Case presentation: A 51-year-old female with a history of a Nissen fundoplication for refractory reflux presented with a 3-month history of heartburn, diarrhea, and 55-pound weight loss. Evaluation included negative upper and lower endoscopies with biopsies and negative MR enterography. A 48-h fecal fat study revealed 501 g of stool and 51 g of fat per 24 h. A serum gastrin level off PPI was elevated at 589 pg/mL with a gastric pH of 2 on gastric aspirate. An EUS, DOTATATE PET scan, and secretin stimulation test were negative for ZE. A standardized test meal with serial gastrin monitoring demonstrated an 8-fold increase in serum gastrin. Open abdominal exploration and intraoperative ultrasound showed no evidence of a gastrinoma and an antrectomy and Billroth II anastomosis was performed in treatment of G-cell hyperplasia. Pathology demonstrated a moderately increased G-cell population. Postoperatively, her hypergastrinemia and steatorrhea resolved and she regained 60 pounds.Conclusion: Antral G-cell hyperplasia should be considered in patients with symptoms suggestive of gastrinoma with negative secretin stimulation testing and imaging studies. A standardized test meal demonstrates a substantial increase in serum gastrin levels and antrectomy is the treatment of choice for refractory symptoms.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"19 1","pages":"428-433"},"PeriodicalIF":0.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calculus Cholecystitis Complicated with Variations of Extrahepatic Bile Duct: Clinical Experience and Aeromedical Analysis of 3 Cases in Aviation Pilots. 航空飞行员结石性胆囊炎合并肝外胆管病变3例临床体会及航空医学分析。

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-06-09 eCollection Date: 2025-01-01 DOI: 10.1159/000546233

Wen-Bing Li, Zeng Xue, Wei Shi, Lu-Bing Wang, Xiao-Jun He, Cheng Wang, Gang Zhao, Ling-Hong Kong, Meng Pu, Cheng-Li Liu, Ya-Lin Kong

{"title":"Calculus Cholecystitis Complicated with Variations of Extrahepatic Bile Duct: Clinical Experience and Aeromedical Analysis of 3 Cases in Aviation Pilots.","authors":"Wen-Bing Li, Zeng Xue, Wei Shi, Lu-Bing Wang, Xiao-Jun He, Cheng Wang, Gang Zhao, Ling-Hong Kong, Meng Pu, Cheng-Li Liu, Ya-Lin Kong","doi":"10.1159/000546233","DOIUrl":"10.1159/000546233","url":null,"abstract":"Introduction: For aviation personnel, calculous cholecystitis often requires surgical treatment because of the potential risks to flight safety whether symptomatic or asymptomatic. Although much effort has been put on the precaution of gallstone formation, the incidence of long-term post-cholecystectomy syndrome (PCS) seems more apparent in the limited number of cases undergoing cholecystectomy. The purpose of article was to elucidate the possible mechanism of gallstone formation and the development of long-term PCS caused by variations of bile duct, as well as choice of surgical treatments, just in this particular group of aviation personnel.Case presentation: Seven aviation pilots who underwent laparoscopic cholecystectomy in recent 5 years were reviewed, and 3 cases who developed long-term PCS because of variations of bile duct were presented. Variations of bile duct included existence of accessory extrahepatic bile, absence of common bile duct, and absence of cystic duct. Long-term PCS was characterized as epigastric dull pain and diarrhea or sparse stool, and became aggravated when resuming trainings of flight stimulations. Dietary adjustment and oral antispasmodic or cholagogic drug therapy, combined with relieving apprehensions after surgery, helped them recover well and resume flight.Conclusion: Variation of bile duct may be an important potential risk for gallstone formation and development of long-term PCS with the cause of probable decrement of bile drainage under the physiological environment of aviation.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"19 1","pages":"412-422"},"PeriodicalIF":0.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First Description of Sprue-Like Enteropathy due to Azilsartan: A Case Report. 阿兹沙坦引起的云杉样肠病1例报告。

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-06-06 eCollection Date: 2025-01-01 DOI: 10.1159/000545217

Luisa Stoeckli, Markus Koster, Tugce Tuerkmen-Uthayanan, Sergio Cogliatti, Stephan Brand

{"title":"First Description of Sprue-Like Enteropathy due to Azilsartan: A Case Report.","authors":"Luisa Stoeckli, Markus Koster, Tugce Tuerkmen-Uthayanan, Sergio Cogliatti, Stephan Brand","doi":"10.1159/000545217","DOIUrl":"10.1159/000545217","url":null,"abstract":"Introduction: Sartan-induced enteropathy is an uncommon side effect of treatment with angiotensin II receptor antagonists (ARBs), which has predominantly been described for olmesartan.Case presentation: For the first time, we describe sartan-induced enteropathy as an adverse drug reaction associated with azilsartan in a 74-year-old male patient who was admitted to the hospital twice within 5 months because of excessive non-bloody diarrhea and weight loss. In this case, histopathological findings of intraepithelial lymphocytosis and intestinal villous atrophy resembled celiac disease; however, celiac disease-specific antibodies remained negative, and a gluten-free diet did not result in significant clinical recovery, while symptoms stopped rapidly after stopping azilsartan. When the patient was seen 5 months later, he was free of clinical symptoms, and histological changes disappeared after stopping azilsartan.Conclusion: This case illustrates sprue-like enteropathy as a potential side effect of azilsartan, emphasizing to consider this differential diagnosis in ARB-treated patients with chronic diarrhea. The causality of our findings was confirmed by drug de-challenge and re-challenge resulting in typical histological changes.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"19 1","pages":"403-411"},"PeriodicalIF":0.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Recurrent Gallstone Ileus Treated with Enterolithotomy Alone. 单纯肠内取石术治疗复发性胆结石性肠梗阻1例。

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-06-05 eCollection Date: 2025-01-01 DOI: 10.1159/000545980

Kisho Noda, Hirofumi Ohno, Keiko Naito, Katsudai Shirakabe, Hirotada Muramatsu, Hiraku Funakoshi

引用次数: 0

Infliximab-Induced Immune Thrombocytopenic Purpura in an Ulcerative Colitis Patient. 溃疡性结肠炎患者英夫利昔单抗诱导的免疫性血小板减少性紫癜。

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-06-04 eCollection Date: 2025-01-01 DOI: 10.1159/000545922

Mark Lai, Timothy Phan, Ola Niewiadomski, Nik Ding

引用次数: 0

Successful Closure of Chronic Colonic Double Perforation Caused by a Plastic Biliary Stent with Over-the-Scope Clip. 塑料胆道支架镜外夹成功闭合慢性结肠双穿孔。

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-05-29 eCollection Date: 2025-01-01 DOI: 10.1159/000545561

Manuel Lehner, Henriette Heinrich, Benjamin Baumgartner, Tobias Heye, Marius Zimmerli

引用次数: 0

Gluten-Associated Neurological Disorders: A Cases Series. 谷蛋白相关神经系统疾病：病例系列。

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-05-29 eCollection Date: 2025-01-01 DOI: 10.1159/000544765

Vismaya S Bachu, Farinaz Ghodrati, Brent L Fogel, Guy A Weiss

引用次数: 0

Hypoalbuminemia and Generalized Edema as the Presenting Symptoms of Celiac Disease in a Two-Year-Old Girl: A Case Report. 低白蛋白血症和全身性水肿是2岁女童乳糜泻的主要症状：1例报告

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.1159/000545732

Michael R Weaver, William C Schultz, Ahmed Rafay Afzal, Kara L Oliver, Osama F Almadhoun

{"title":"Hypoalbuminemia and Generalized Edema as the Presenting Symptoms of Celiac Disease in a Two-Year-Old Girl: A Case Report.","authors":"Michael R Weaver, William C Schultz, Ahmed Rafay Afzal, Kara L Oliver, Osama F Almadhoun","doi":"10.1159/000545732","DOIUrl":"10.1159/000545732","url":null,"abstract":"Introduction: Celiac disease (CD) is a systemic, immune-mediated enteropathy that occurs following dietary consumption of gluten in genetically susceptible individuals. The global prevalence of celiac disease is estimated to be approximately 1.4%, with variation based on age, sex, and geographic location. CD typically presents early in life with diarrhea, abdominal pain, abdominal distention, weight loss, and impaired growth. In severe cases, patients with CD can present in a state of celiac crisis (CC), classically characterized with profuse diarrhea and life-threatening metabolic derangements.Case presentation: In this report, we discuss a 23-month-old girl in a state of CC who presented atypically with hypoalbuminemia, generalized edema, and constipation.Conclusion: Even in the presence of atypical symptoms, such as edema or constipation, CD should be considered as a differential diagnosis in pediatric patients with severe gastrointestinal disturbances. Additionally, we propose a revised definition of CC that is specific to the pediatric population.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"19 1","pages":"373-380"},"PeriodicalIF":0.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MALToma Discovered on a Hemorrhagic Shock Associated with Gastric Dieulafoy's Lesion: A Case Report. 胃粘膜瘤并发出血性休克1例报告。

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-05-20 eCollection Date: 2025-01-01 DOI: 10.1159/000545012

Elina Lam, Raoul Muteganya, Nathalie Nagy, Marianna Arvanitakis, Angelique Covas, Emmanuel Toussaint

{"title":"MALToma Discovered on a Hemorrhagic Shock Associated with Gastric Dieulafoy's Lesion: A Case Report.","authors":"Elina Lam, Raoul Muteganya, Nathalie Nagy, Marianna Arvanitakis, Angelique Covas, Emmanuel Toussaint","doi":"10.1159/000545012","DOIUrl":"10.1159/000545012","url":null,"abstract":"Introduction: Dieulafoy's lesion is a rare but severe cause of digestive bleeding and can rarely present as a hemorrhagic shock which is associated with a severe prognosis. MALToma is a B-cell lymphoma of the mucosa-associated lymphoid tissue. It was reported that MALToma can be revealed by a Dieulafoy's lesion. Due to the lack of specific endoscopic or clinical characteristics, several endoscopies may be needed to establish the diagnosis of MALToma.Case presentation: A 61-year-old male patient presented to the emergency department with melena and hematemesis. The patient was transferred to the intensive care unit due to hemorrhagic shock. The endoscopic work-up showed large gastric folds which were later confirmed as MALToma in anatomo-pathologic analysis. The echoendoscopy showed a vessel going through the entire gastric wall which endoscopically corresponded to a red non-bleeding lesion, confirming Dieulafoy's lesion as the origin of the bleeding. The patient received an endoscopic treatment and was rapidly discharged from the intensive care unit. The evolution was spontaneously favorable, and there was no repeat active bleeding.Conclusion: A gastric MALToma was discovered thanks to a hemorrhagic shock on a Dieulafoy's lesion which has not yet been described in the literature.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"19 1","pages":"366-372"},"PeriodicalIF":0.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Celiac Disease as a Cause of Malabsorption: A Clinic-Pathological Series of Five Cases. 乳糜泻作为吸收不良的病因：临床病理五例分析

IF 0.5

Case Reports in Gastroenterology Pub Date : 2025-05-14 eCollection Date: 2025-01-01 DOI: 10.1159/000545589

Archana Chirag Buch, Sargam Dhaliwal, Mangesh Londhe, Tejaswini Rajesh Shrirao

{"title":"Celiac Disease as a Cause of Malabsorption: A Clinic-Pathological Series of Five Cases.","authors":"Archana Chirag Buch, Sargam Dhaliwal, Mangesh Londhe, Tejaswini Rajesh Shrirao","doi":"10.1159/000545589","DOIUrl":"https://doi.org/10.1159/000545589","url":null,"abstract":"Introduction: Celiac disease (CD) also called gluten-sensitive enteropathy is a noninfectious and an autoimmune cause of malabsorption. It can be difficult to diagnose because of wide range of gastrointestinal and extraintestinal symptoms.Case presentation: Here, we present 5 cases of CD out of total 160 patients assessed for malabsorption at a tertiary care facility in western Maharashtra between 2022 and 2023. The male-to-female ratio was 1.5:1, and the age of patients ranged from 2 to 60. Chronic diarrhea was the most prevalent symptom, followed by weight loss and stomach pain. In each case, laboratory results showed elevated tissue transglutaminase IgA (tTG-IgA), along with varied levels of calcium and vitamin D deficiency. Two cases had normal endoscopic findings, one had whitish granular mucosa, while 2 cases had duodenal fold scalloping. Histopathological analysis verified the diagnosis, classifying the cases as Marsh types 3a, 3b, and 3c. There was no relationship between the severity of the histopathology and tTG-IgA levels.Conclusion: This case series of 5 cases takes into account the prevalence of CD as a cause of malabsorption in western India. It also emphasizes the significance of taking CD into account in patients with malabsorption and the necessity of following a multidisciplinary approach encompassing nutritional assessment, clinical evaluation, histopathology, and serology for an accurate diagnosis and course of treatment.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"19 1","pages":"358-365"},"PeriodicalIF":0.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0