Case Reports in Surgery最新文献

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A Twist in the Tale: Rare Diagnosis of Lipomatosis of the Appendix. 故事的一个转折:阑尾脂肪瘤病的罕见诊断。
IF 0.6
Case Reports in Surgery Pub Date : 2026-09-29 eCollection Date: 2026-01-01 DOI: 10.1155/cris/5436727
David Aini, Nicholas Markovic, Emily Rienzo, Arthur Topilow, Glenn Parker
{"title":"A Twist in the Tale: Rare Diagnosis of Lipomatosis of the Appendix.","authors":"David Aini, Nicholas Markovic, Emily Rienzo, Arthur Topilow, Glenn Parker","doi":"10.1155/cris/5436727","DOIUrl":"10.1155/cris/5436727","url":null,"abstract":"<p><p>A 66-year-old white male with a history of diverticulosis and prediabetes presented with right lower quadrant (RLQ) abdominal pain lasting 1 month. On physical examination, the abdomen was soft without tenderness or palpable masses. CT imaging showed an enlarged appendix with a diameter of 1 cm with no surrounding inflammation. A laparoscopic appendectomy was performed, and the patient's symptoms resolved within 3 weeks. Histopathology revealed lipomatosis of the appendix, an extraordinarily rare diagnosis which has only been reported five times prior to our case. This case study aims to increase available information on this disease to aid future diagnosis and treatment.</p>","PeriodicalId":9600,"journal":{"name":"Case Reports in Surgery","volume":"2026 ","pages":"5436727"},"PeriodicalIF":0.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traumatic Ruptured Hepatic Cyst Managed by Laparoscopic Fenestration Assisted With Indocyanine Green (ICG) Fluorescence: A Case Report. 腹腔镜开窗辅助吲哚菁绿(ICG)荧光治疗外伤性肝囊肿1例
IF 0.6
Case Reports in Surgery Pub Date : 2026-09-29 eCollection Date: 2026-01-01 DOI: 10.1155/cris/2283895
Rikuto Uryu, Hirofumi Hirao, Kazuyuki Nagai, Satoshi Ogiso, Shinya Okumura, Tomoaki Yoh, Kei Yamane, Etsuro Hatano
{"title":"Traumatic Ruptured Hepatic Cyst Managed by Laparoscopic Fenestration Assisted With Indocyanine Green (ICG) Fluorescence: A Case Report.","authors":"Rikuto Uryu, Hirofumi Hirao, Kazuyuki Nagai, Satoshi Ogiso, Shinya Okumura, Tomoaki Yoh, Kei Yamane, Etsuro Hatano","doi":"10.1155/cris/2283895","DOIUrl":"10.1155/cris/2283895","url":null,"abstract":"<p><p>Nonparasitic hepatic cysts are common and generally asymptomatic. However, complications such as infection, hemorrhage, or rupture of the cyst necessitate therapeutic intervention. We report a rare case of traumatic rupture of a large hepatic cyst managed laparoscopically with the assistance of indocyanine green (ICG) fluorescence. A 57-year-old woman had been followed for 2 years for a large cystic lesion in segments 4 (S4) and 8 (S8) of the liver, suspected to be a mucinous cystic neoplasm (MCN). As the S4 cyst grew to 15 cm, surgical resection was planned. However, she presented to our emergency department after blunt abdominal trauma sustained from a fall at home. Computed tomography (CT) revealed rupture of the S4 cyst with massive ascites. Although initially managed conservatively with little abdominal symptoms, she developed worsening abdominal pain and progressive anemia 2 days postadmission, raising concern for cyst-related hemorrhage and possible bile leakage. Emergent laparoscopic surgery revealed hemoperitoneum and bleeding from the ruptured cyst wall. ICG was administered intravenously immediately after anesthesia induction to visualize the communication between the cyst and the biliary tract by fluorescence imaging. Then, laparoscopic fenestration was performed under ICG guidance. The patient was discharged on postoperative day (POD) 6 without any complications. We successfully treated a rare case of traumatic hepatic cyst rupture by laparoscopic fenestration with ICG imaging. ICG fluorescence was a helpful adjunct for intraoperative assessment of the potential bile duct in the cyst, ensuring the safety of the operative procedure.</p>","PeriodicalId":9600,"journal":{"name":"Case Reports in Surgery","volume":"2026 ","pages":"2283895"},"PeriodicalIF":0.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modified Primary PSARP for an Adult Patient With Imperforate Anus With Rectoperineal Fistula in a Low-Resource Setting: Case Report. 改良原发性PSARP治疗低资源环境下肛门闭锁伴直肠会阴瘘的成人患者:病例报告。
IF 0.6
Case Reports in Surgery Pub Date : 2026-09-28 eCollection Date: 2026-01-01 DOI: 10.1155/cris/3272170
Awol Yemane Legesse, Hale Teka, Mekonen Hafte, Sia Nyandemo, Sherif Emil
{"title":"Modified Primary PSARP for an Adult Patient With Imperforate Anus With Rectoperineal Fistula in a Low-Resource Setting: Case Report.","authors":"Awol Yemane Legesse, Hale Teka, Mekonen Hafte, Sia Nyandemo, Sherif Emil","doi":"10.1155/cris/3272170","DOIUrl":"10.1155/cris/3272170","url":null,"abstract":"<p><p>Anorectal malformations (ARMs) are congenital anomalies that include a variety of anomalies. An imperforate anus is the most typical presentation of all the ARMs. It can present with a fistula of the vestibule, vagina, fourchette, and perineum. Though in developed countries, it is diagnosed early and managed during the first few months of life, in low-resource settings, patients present with ARM later in life. Our case presented a 24-year-old with an imperforate anus and rectoperineal fistula. This is the oldest patient to be reported in the literature with an imperforate anus. Modified posterior sagittal anorectoplasty was done. The technique employed is perineum-preserving anal transposition. The procedure was successful. During 6 months of follow-up, the reconstruction appeared smooth; she could control flatus and stool. She can differentiate between gas and stool. No constipation and no soiling. In low-resource settings, patients present late during adulthood. Modified (perineum-sparing) posterior sagittal anorectoplasty with anal transposition is an appropriate option for adult patients with ARMs.</p>","PeriodicalId":9600,"journal":{"name":"Case Reports in Surgery","volume":"2026 ","pages":"3272170"},"PeriodicalIF":0.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Where Sepsis Meets Haemorrhage: A Case Report of Spontaneous Splenic Rupture Following Perforated Diverticulitis. 败血症与出血:穿孔性憩室炎后自发性脾破裂1例报告。
IF 0.6
Case Reports in Surgery Pub Date : 2026-09-24 eCollection Date: 2026-01-01 DOI: 10.1155/cris/5579279
Shasha Haycock, Annie Jiao Wang, Kristy Mansour, Khang Duy Ricky Le, Andrew MacLeod
{"title":"Where Sepsis Meets Haemorrhage: A Case Report of Spontaneous Splenic Rupture Following Perforated Diverticulitis.","authors":"Shasha Haycock, Annie Jiao Wang, Kristy Mansour, Khang Duy Ricky Le, Andrew MacLeod","doi":"10.1155/cris/5579279","DOIUrl":"10.1155/cris/5579279","url":null,"abstract":"<p><p>Atraumatic splenic rupture is an extremely rare cause of deterioration in the context of concurrent abdominal pathology. This case report describes rapid deterioration and shock in a mid-50s-year-old man with acute complicated sigmoid diverticulitis 3 days into admission without history of abdominal trauma. This was associated with a rapid haemoglobin (Hb) drop from 119 to 37 g/L, which necessitated activation of the massive transfusion protocol. An atraumatic splenic rupture was subsequently diagnosed on urgent exploratory laparotomy. The patient underwent splenectomy followed by a Hartmann's procedure for treatment of perforated sigmoid diverticulitis. This case highlights the importance of maintaining a broad differential diagnosis and consideration of concurrent pathologies for deteriorating patients with common acute infectious abdominal pathologies, including appendicitis or diverticulitis, as missed diagnosis of atraumatic splenic rupture may be fatal due to profound haemorrhage.</p>","PeriodicalId":9600,"journal":{"name":"Case Reports in Surgery","volume":"2026 ","pages":"5579279"},"PeriodicalIF":0.6,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13602168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Surgical Management of an Advanced Abdominal Pregnancy in a Resource-Limited Setting. 在资源有限的情况下,成功的手术治疗晚期腹部妊娠。
IF 0.6
Case Reports in Surgery Pub Date : 2026-09-23 eCollection Date: 2026-01-01 DOI: 10.1155/cris/1054912
Pietro Pasquini, Faraja Bernard Mwidete, Agnes Mlawa, Giacomo Antonini
{"title":"Successful Surgical Management of an Advanced Abdominal Pregnancy in a Resource-Limited Setting.","authors":"Pietro Pasquini, Faraja Bernard Mwidete, Agnes Mlawa, Giacomo Antonini","doi":"10.1155/cris/1054912","DOIUrl":"10.1155/cris/1054912","url":null,"abstract":"<p><strong>Introduction: </strong>Abdominal pregnancy (AP) is a rare ectopic pregnancy (EP), often misdiagnosed, with no standardized treatment due to limited literature. Most APs result in early pregnancy loss, making advanced AP cases even rarer. We present a case of advanced AP in a limited resource setting.</p><p><strong>Case presentation: </strong>A 23-year-old woman with a previous cesarean delivery presented with a 2-month history of amenorrhea, chest pain, and lower abdominal pain. Despite a positive pregnancy test, pelvic ultrasound showed no intrauterine or EP but revealed a paracecal mass, raising suspicion of an appendiceal abscess. Because of financial constraints, no further diagnostic investigations were performed, and urgent exploratory laparotomy was undertaken. Surgery revealed abortive material, including fetal bone fragments consistent with a 21-23-week pregnancy. Ischemic placental tissue infiltrated the serosa and deeper layers of the cecum and distal ileum, with active bleeding, deperitonealization, and partial bowel obstruction. An ileocecal resection with ileocolic anastomosis was therefore performed. Recovery was uneventful, with no complications at 30-day and 18-month follow-up.</p><p><strong>Conclusion: </strong>High clinical suspicion for AP is crucial, especially in cases with inconclusive imaging. A tailored surgical approach to manage placental invasion can lead to positive outcomes even in complex cases of advanced AP.</p>","PeriodicalId":9600,"journal":{"name":"Case Reports in Surgery","volume":"2026 ","pages":"1054912"},"PeriodicalIF":0.6,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13601727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delayed Right Hemidiaphragm Rupture After Blunt Trauma Repaired With Prolene Mesh: A Case Report. 聚丙烯补片修复钝性创伤后迟发性右半膈破裂1例。
IF 0.6
Case Reports in Surgery Pub Date : 2026-09-23 eCollection Date: 2026-01-01 DOI: 10.1155/cris/3439339
Zahra Sadin, Aghajanzadeh Manochehr, Sadin Mohammadreza, Alavi Foumani Ali, Fakhr Mousavi Ali Asghar, Mosaffaee Omid, Ramezani Naghi, Farzin Mohaya
{"title":"Delayed Right Hemidiaphragm Rupture After Blunt Trauma Repaired With Prolene Mesh: A Case Report.","authors":"Zahra Sadin, Aghajanzadeh Manochehr, Sadin Mohammadreza, Alavi Foumani Ali, Fakhr Mousavi Ali Asghar, Mosaffaee Omid, Ramezani Naghi, Farzin Mohaya","doi":"10.1155/cris/3439339","DOIUrl":"https://doi.org/10.1155/cris/3439339","url":null,"abstract":"<p><p>Traumatic diaphragmatic rupture (TDR) is a rare but serious injury. It most commonly results from high-impact blunt trauma. Right-sided ruptures are particularly uncommon due to the protective effect of the liver. Delayed presentation can cause diagnostic challenges, as the injury may remain clinically silent for years before complications such as organ herniation. We report a case of a 65-year-old male who presented with progressive dyspnea, right-sided chest pain, and right upper quadrant abdominal discomfort 4 years after a severe motor vehicle accident. Chest radiography revealed a heterogeneous opacity in the right hemithorax, and contrast-enhanced CT confirmed right hemidiaphragmatic rupture with intrathoracic herniation of the liver. The patient underwent urgent surgical repair. A large diaphragmatic defect was identified and repaired with a Prolene mesh in a tension-free fashion. The postoperative course was uneventful, with complete resolution of symptoms. This case highlights the importance of maintaining clinical suspicion for delayed diaphragmatic rupture in patients with a remote history of blunt trauma, even when initial imaging was normal. Contrast-enhanced CT remains the diagnostic standard, and Prolene mesh repair is a surgical solution for large diaphragmatic defects.</p>","PeriodicalId":9600,"journal":{"name":"Case Reports in Surgery","volume":"2026 ","pages":"3439339"},"PeriodicalIF":0.6,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13598677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unexpected Link Between Myasthenia Gravis and Lung Adenocarcinoma: A Case Report. 重症肌无力与肺腺癌的意外联系1例。
IF 0.6
Case Reports in Surgery Pub Date : 2026-09-21 eCollection Date: 2026-01-01 DOI: 10.1155/cris/6576971
Biruke Temesgen, Fitsum A Gemechu, Michael A Negussie, Liya T Tena, Mesfin Ayalew Tsegaye, Seyoum Kassa
{"title":"Unexpected Link Between Myasthenia Gravis and Lung Adenocarcinoma: A Case Report.","authors":"Biruke Temesgen, Fitsum A Gemechu, Michael A Negussie, Liya T Tena, Mesfin Ayalew Tsegaye, Seyoum Kassa","doi":"10.1155/cris/6576971","DOIUrl":"10.1155/cris/6576971","url":null,"abstract":"<p><strong>Introduction: </strong>While myasthenia gravis (MG) is commonly associated with thymic abnormalities and other autoimmune diseases, its association with malignancies, particularly lung adenocarcinoma, is exceptionally rare.</p><p><strong>Case presentation: </strong>A 65-year-old male presented with bilateral eyelid drooping, double vision, and fatigable limb weakness, alongside a 4-month history of a non-productive cough. Neurological examination revealed bilateral ptosis, sluggish pupillary reactions, and internuclear ophthalmoplegia. Investigations demonstrated elevated anti-acetylcholine receptor (AChR) antibody levels and nerve conduction studies (NCSs) consistent with MG. Imaging revealed a right middle lobe pulmonary nodule, confirmed as adenocarcinoma via fine-needle aspiration. The patient showed symptomatic improvement with pyridostigmine and prednisolone and underwent surgical resection followed by chemotherapy.</p><p><strong>Discussion: </strong>Paraneoplastic neurologic syndromes (PNSs), though rare, can manifest as MG in association with malignancies. While MG is typically linked to thymoma, this case illustrates its coexistence with pulmonary adenocarcinoma, a seldom-reported phenomenon. Cross-reactivity between autoantibodies targeting neuronal and muscle AChRs may underlie the pathophysiology, emphasizing the need to evaluate underlying malignancies in atypical MG presentations.</p><p><strong>Conclusion: </strong>Seropositive MG can present as a paraneoplastic syndrome in association with adenocarcinoma of the lung, highlighting the importance of investigating underlying malignancies in atypical or newly diagnosed autoimmune conditions.</p>","PeriodicalId":9600,"journal":{"name":"Case Reports in Surgery","volume":"2026 ","pages":"6576971"},"PeriodicalIF":0.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13594766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gallbladder Hypoplasia With Intestinal Malrotation in a Patient With Apert Syndrome: A Case Report. Apert综合征患者胆囊发育不全伴肠道旋转不良1例报告。
IF 0.6
Case Reports in Surgery Pub Date : 2026-09-18 eCollection Date: 2026-01-01 DOI: 10.1155/cris/5588836
Lavanya Easwaran, Sage A Vincent, Jose L Diaz-Miron
{"title":"Gallbladder Hypoplasia With Intestinal Malrotation in a Patient With Apert Syndrome: A Case Report.","authors":"Lavanya Easwaran, Sage A Vincent, Jose L Diaz-Miron","doi":"10.1155/cris/5588836","DOIUrl":"10.1155/cris/5588836","url":null,"abstract":"<p><p>Gallbladder agenesis and hypoplasia are rare diseases that are often asymptomatic but can present as biliary colic in the 5<sup>th</sup> or 6<sup>th</sup> decade of life. The incidence of gallbladder agenesis and hypoplasia has not been well documented in the pediatric population, and concomitant congenital anomalies can result in a complex clinical presentation. This is a case report of a 20-year-old male with Apert disease with a 6-month history of chronic right upper quadrant (RUQ) pain with imaging that demonstrated both gallbladder hypoplasia and malrotation without volvulus. He underwent both a cholecystectomy and a Ladd's procedure upon intraoperative identification of a hypoplastic gallbladder and had complete resolution of pain. The etiology of this patient's abdominal pain cannot be conclusively identified due to the multiple procedures performed, but prior studies indicate that it may be more attributed to the gallbladder hypoplasia. This case highlights the difficulty of both gallbladder hypoplasia diagnosis and its surgical management. Gallbladder hypoplasia is exceedingly rare, and a high clinical suspicion is needed to diagnose its presence in patients with genetic predispositions for biliary disease. While there is no gold standard for its management, initial recommendations are to proceed with conservative treatment with antispasmodics before operative intervention. In the case of operative intervention, surgeons must understand the high risks of operating in these patients due to the degree of fibrosis.</p>","PeriodicalId":9600,"journal":{"name":"Case Reports in Surgery","volume":"2026 ","pages":"5588836"},"PeriodicalIF":0.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Synchronous Laparoscopic Surgery for Sigmoid Colon Cancer Inaccessible by Colonoscopy and Left Adrenal Pheochromocytoma. 结肠镜及左肾上腺嗜铬细胞瘤乙状结肠同步腹腔镜手术1例。
IF 0.6
Case Reports in Surgery Pub Date : 2026-09-16 eCollection Date: 2026-01-01 DOI: 10.1155/cris/7531559
Yasuhito Tsubokawa, Takaharu Kato
{"title":"A Case of Synchronous Laparoscopic Surgery for Sigmoid Colon Cancer Inaccessible by Colonoscopy and Left Adrenal Pheochromocytoma.","authors":"Yasuhito Tsubokawa, Takaharu Kato","doi":"10.1155/cris/7531559","DOIUrl":"https://doi.org/10.1155/cris/7531559","url":null,"abstract":"<p><p>We report the case of a 65-year-old man with sigmoid colon cancer who presented with left lower abdominal pain. Preoperative computed tomography (CT) revealed a tumor in the left adrenal gland. As the patient had no clinical symptoms suggestive of catecholamine excess, the lesion was initially suspected to be a left adrenal metastasis; however, endocrinological evaluation was performed to establish the differential diagnosis. According to the Endocrine Society Clinical Practice Guidelines, the patient was diagnosed with a left adrenal pheochromocytoma. To reduce overall surgical invasiveness and shorten the hospital stay, synchronous laparoscopic resection of the sigmoid colon cancer and the adrenal tumor was planned. The procedure was performed using five ports commonly utilized for left-sided colectomy, with an additional epigastric port, resulting in a total of six ports. Postoperatively, the patient developed adhesive small bowel obstruction, which resolved with conservative management, and he was discharged on postoperative day 19. Simultaneous laparoscopic resection of sigmoid colon cancer and left adrenal pheochromocytoma is extremely rare. The present case provides valuable insight suggesting that safe one-stage surgery may be feasible through meticulous perioperative planning and the use of a transperitoneal approach with a shared operative field. Further accumulation of similar cases is warranted to establish optimal treatment strategies.</p>","PeriodicalId":9600,"journal":{"name":"Case Reports in Surgery","volume":"2026 ","pages":"7531559"},"PeriodicalIF":0.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13579527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatocellular Carcinoma Arising From Well-Differentiated Hepatocellular Neoplasm of Uncertain Malignant Potential in a Patient With Abernethy Malformation. 肝细胞癌由分化良好的肝细胞肿瘤引起,恶性潜能不确定。
IF 0.6
Case Reports in Surgery Pub Date : 2026-09-16 eCollection Date: 2026-01-01 DOI: 10.1155/cris/5595846
Keiichi Kinowaki, Jacqueline E Birkness-Gartman, Ihab Kamel, Linda Chu, Robert A Anders, Christopher R Shubert, Kiyoko Oshima
{"title":"Hepatocellular Carcinoma Arising From Well-Differentiated Hepatocellular Neoplasm of Uncertain Malignant Potential in a Patient With Abernethy Malformation.","authors":"Keiichi Kinowaki, Jacqueline E Birkness-Gartman, Ihab Kamel, Linda Chu, Robert A Anders, Christopher R Shubert, Kiyoko Oshima","doi":"10.1155/cris/5595846","DOIUrl":"10.1155/cris/5595846","url":null,"abstract":"<p><p>Abernethy malformation is a rare congenital extrahepatic mesocaval shunt (CEMS) in which mesenteric venous blood bypasses the liver completely (type I) or partially (type II) and drains directly into the vena cava. In complete CEMS (type I), the intrahepatic portal vein is absent. The resulting lack of portal flow is associated with the development of hepatic nodules, such as focal nodular hyperplasia (FNH), hepatocellular adenoma (HCA), and hepatocellular carcinoma (HCC). These lesions have a higher risk of malignant transformation than conventional adenomas. The term hepatocellular neoplasm of uncertain malignant potential (HUMP) has been proposed for borderline lesions between HCA and well-differentiated HCC, diagnosed based on atypical histological, genetic, or clinical features suggesting a possible malignant potential. However, the exact risk of malignant transformation is unknown. We present the case of a 32-year-old man with Type I Abernethy malformation who developed malignant transformation of a HUMP over a 15-year period. Serial hepatic resections performed at other institutions demonstrated histological progression from HUMP to HCC with subsequent lung metastasis. This gradual transformation has been documented in several surgical specimens. This case highlights the need for careful recognition of HUMP in patients with Abernethy malformation, as timely liver transplantation may be essential to prevent malignant transformation and achieve curative outcomes.</p>","PeriodicalId":9600,"journal":{"name":"Case Reports in Surgery","volume":"2026 ","pages":"5595846"},"PeriodicalIF":0.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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