Primary Neuroendocrine Tumor of the Breast: A Rare Case.

IF 0.6 Q4 SURGERY
Case Reports in Surgery Pub Date : 2025-04-21 eCollection Date: 2025-01-01 DOI:10.1155/cris/5595521
She's Magnolia C Ycong, Hannah Lois R Kangleon-Tan, Kristoff Armand E Tan
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引用次数: 0

Abstract

Primary neuroendocrine tumors (NETs) predominantly affect postmenopausal women. This case study focused on a 54-year-old woman who presented with a painless right breast lump. While the lump exhibited estrogen and progesterone receptor (PR) positivity, it lacked human epidermal growth factor receptor 2 expression. Further evaluation revealed positivity for the neuroendocrine markers chromogranin A (CGA) and synaptophysin (SYN). It also revealed a 3% positive Ki-67 proliferation index. Treatment for neuroendocrine breast cancer (NEBC) mirrors that of standard invasive breast cancer: breast conservation or mastectomy combined with sentinel lymph node biopsy or axillary dissection. The patient underwent a right mastectomy with sentinel lymph node biopsy, followed by hormonal therapy based on her tumor's immunohistochemical profile. Due to the low incidence and limited research on primary NETs, their exact origin remains shrouded in mystery. Accurate diagnosis, specific treatment options, and long-term prognosis remain significant challenges in managing this rare form of breast cancer.

乳腺原发性神经内分泌肿瘤一例罕见。
原发性神经内分泌肿瘤(NETs)主要影响绝经后妇女。本病例研究集中于一位54岁的女性,她表现为右侧乳房无痛性肿块。虽然肿块显示雌激素和孕激素受体(PR)阳性,但缺乏人表皮生长因子受体2的表达。进一步评估显示神经内分泌标记物嗜铬粒蛋白A (CGA)和突触素(SYN)呈阳性。Ki-67增殖指数3%阳性。神经内分泌乳腺癌(NEBC)的治疗方法与标准浸润性乳腺癌相同:保留乳房或乳房切除术结合前哨淋巴结活检或腋窝清扫。患者接受了右侧乳房切除术和前哨淋巴结活检,随后根据肿瘤的免疫组织化学特征进行激素治疗。由于原发性NETs发病率低,研究有限,其确切起源仍然是一个谜。准确的诊断、具体的治疗方案和长期预后仍然是治疗这种罕见乳腺癌的重大挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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60
审稿时长
13 weeks
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