William Abel, Christopher J Peterson, David P Lebel, Douglas J Grider
{"title":"原发性肠系膜高分化炎性脂肪肉瘤伴粘膜延伸:一种高误诊风险的病变。","authors":"William Abel, Christopher J Peterson, David P Lebel, Douglas J Grider","doi":"10.1155/cris/9162938","DOIUrl":null,"url":null,"abstract":"<p><p>Well-differentiated liposarcomas are common retroperitoneal lesions, but exceedingly rare when primary to the small bowel mesentery, with only a handful of cases reported in the literature. Presented is a patient with a primary mesenteric well-differentiated inflammatory liposarcoma with mucosal extension at high risk for misdiagnosis. A broad differential diagnosis with careful histopathologic observation, ancillary immunohistochemical studies, and fluorescent in situ hybridization for MDM2 amplification are key to make a correct diagnosis. This is especially true if such a lesion was first noted in the lamina propria on histopathology from an endoscopic mucosal biopsy.</p>","PeriodicalId":9600,"journal":{"name":"Case Reports in Surgery","volume":"2025 ","pages":"9162938"},"PeriodicalIF":0.6000,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033056/pdf/","citationCount":"0","resultStr":"{\"title\":\"Primary Mesenteric Well-Differentiated Inflammatory Liposarcoma With Mucosal Extension: A Lesion With High Risk for Misdiagnosis.\",\"authors\":\"William Abel, Christopher J Peterson, David P Lebel, Douglas J Grider\",\"doi\":\"10.1155/cris/9162938\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Well-differentiated liposarcomas are common retroperitoneal lesions, but exceedingly rare when primary to the small bowel mesentery, with only a handful of cases reported in the literature. Presented is a patient with a primary mesenteric well-differentiated inflammatory liposarcoma with mucosal extension at high risk for misdiagnosis. A broad differential diagnosis with careful histopathologic observation, ancillary immunohistochemical studies, and fluorescent in situ hybridization for MDM2 amplification are key to make a correct diagnosis. This is especially true if such a lesion was first noted in the lamina propria on histopathology from an endoscopic mucosal biopsy.</p>\",\"PeriodicalId\":9600,\"journal\":{\"name\":\"Case Reports in Surgery\",\"volume\":\"2025 \",\"pages\":\"9162938\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-04-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033056/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Case Reports in Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/cris/9162938\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Reports in Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/cris/9162938","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}
Primary Mesenteric Well-Differentiated Inflammatory Liposarcoma With Mucosal Extension: A Lesion With High Risk for Misdiagnosis.
Well-differentiated liposarcomas are common retroperitoneal lesions, but exceedingly rare when primary to the small bowel mesentery, with only a handful of cases reported in the literature. Presented is a patient with a primary mesenteric well-differentiated inflammatory liposarcoma with mucosal extension at high risk for misdiagnosis. A broad differential diagnosis with careful histopathologic observation, ancillary immunohistochemical studies, and fluorescent in situ hybridization for MDM2 amplification are key to make a correct diagnosis. This is especially true if such a lesion was first noted in the lamina propria on histopathology from an endoscopic mucosal biopsy.