Advanced biomedical research最新文献

{"title":"Investigation of Lipid Profile in Patients with Cerebrovascular Diseases: Systematic Review and Meta-Analysis.","authors":"Fatemeh Heydari, Mahboobeh Tajvidi, Seyed Mohammad Mohammadi, Naser Kamyari, Faezeh Mohammadshahi, Hadis Maleki, Negin Zeinivand, Esmat Radmanesh, Reza Pakzad","doi":"10.4103/abr.abr_360_23","DOIUrl":"https://doi.org/10.4103/abr.abr_360_23","url":null,"abstract":"<p><p>Cerebrovascular diseases are caused by issues in the brain's blood vessels, resulting in ischemic and hemorrhagic strokes. The association between serum lipid profile and ischemic or hemorrhagic stroke has shown conflicting results in some studies. We conducted a comprehensive review and meta-analysis to investigate the potential link between plasma lipid profile and cerebrovascular disease. Our study followed the guidelines of PRISMA 2021 for systematic reviews and meta-analysis, conducting a thorough analysis. We searched multiple databases, including Medline, Google Scholar, Scopus, Web of Science, and Embase, to identify studies on lipid profiles in cerebrovascular diseases. We included studies published up to June 2021. After searching various databases, 24,346 studies were found. Finally, 36 studies were included in the meta-analysis. The meta-analysis estimated the odds ratio (95% CI) for different total cholesterol levels to be 1.12 (1.02-1.22). The odds ratios (95% CI) for different LDL, HDL, and triglyceride levels were estimated to be 1.02 (0.98-1.07), <i>P</i> < 0.001, 0.97 (0.93-1.02), <i>P</i> < 0.001, and 1.01 (0.97-1.04), respectively. According to Egger's test, no noteworthy publication bias was found in the meta-analysis (coefficient: -0.26, <i>P</i>: 0.919). According to this meta-analysis, the risk of stroke increases with the increase in total cholesterol level. It was discovered that there is no notable correlation between the incidence of stroke and varying levels of LDL, HDL, or triglycerides. Further research is required to validate these findings.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"11"},"PeriodicalIF":0.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microalgae: A Treasure Trove of Anticancer Nutraceuticals and Promising Therapeutic Mechanisms.","authors":"Sajjad Masoumi, Maryam Zokaei, Ardavan Ahmadvand, Nogol Ghalamkarpour, Naghmeh Asadimanesh, Armin Azarimatin, Khashayar Fattah, Zahra Payandeh, Masoumeh Rostami, Afsaneh Farjami, Rajan Kumar Pandey, Mohsen Nabi-Afjadi","doi":"10.4103/abr.abr_101_24","DOIUrl":"https://doi.org/10.4103/abr.abr_101_24","url":null,"abstract":"<p><p>With cancer remaining a global health concern, the need for new and effective preventive and treatment methods is paramount. Microalgae have emerged as a potential source of anticancer nutraceuticals. Our research indicates that substances produced from microalgae, such as carotenoids, polyunsaturated fatty acids, phycocyanin, and polysaccharides, have shown anticancer effects in both laboratory and human investigations. Carotenoids, including astaxanthin, have shown the ability to hinder the development of tumors and trigger programmed cell death (apoptosis) in several types of cancer cells. Moreover, studies have shown that phycocyanin, a blue pigment present in some species of microalgae, has properties that help reduce inflammation and combat cancer. Potential future research directions include expanding the scope of the study to encompass a diverse range of microalgae species, identifying other compounds with anticancer properties, and investigating the mechanisms by which chemicals derived from microalgae function in the treatment and prevention of cancer. Moreover, it is important to establish scalable and sustainable procedures for the industrial production of compounds derived from microalgae. In conclusion, our evaluation reveals that microalgae have enormous potential as a source of anticancer nutraceuticals, containing a variety of bioactive substances that could eventually lead to the development of novel and effective cancer prevention and treatment methods. To realize the maximum potential of chemicals derived from microalgae, it is necessary to develop a sustainable and environmentally benign industry and to continue research in this area.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"5"},"PeriodicalIF":0.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case-Control Study of the Association of Novel Androgens (11-KT and DHT), Classical Androgens (Testosterone and DHEAS), Hormones (LH, FSH, 17-OHP, Insulin, and SHBG), Insulin Resistance (HOMA-IR), and Dyslipidemia in Polycystic Ovarian Syndrome (PCOS).","authors":"Nirmal Kumar, Neera Sharma, Smita Roy, Indu Chawla, Lokesh Kumar Sharma","doi":"10.4103/abr.abr_262_23","DOIUrl":"https://doi.org/10.4103/abr.abr_262_23","url":null,"abstract":"<p><strong>Background: </strong>The measurement of androgens (testosterone and dehydroepiandrosterone sulfate (DHEAS)) remains standard for the evaluation of polycystic ovarian syndrome (PCOS) women. However, other early novel androgen markers, 5 alpha-dihydrotestosterone (DHT) and 11-ketotestosterone (11-KT), may open a separate path of measurement, which may be more potent. The study was conducted with the objectives to analyze the association of 11-KT and DHT with established markers and with the clinical profile of PCOS patients.</p><p><strong>Materials and methods: </strong>A case-control study was conducted on 30 newly diagnosed cases of PCOS as per the Rotterdam criteria and 30 age-matched controls. The estimation of testosterone, DHEAS, 11-KT, and DHT was performed by the enzyme-linked immunoassay (ELISA) method. The assessment of biochemical and hormonal parameters was compared and correlated with 11-KT and DHT.</p><p><strong>Results: </strong>Compared to the controls, cases had significantly higher 11-KT (20.81 ± 3.53 vs. 15.83 ± 2.67 nmol/L, <i>P</i> < 0.0001) and DHT (154.39 vs. 71.02 pg/mL, <i>P</i> < 0.0001). 11-KT showed a significant positive correlation with total testosterone (TT) (r = 0.555) and DHEAS (r = 0.501). DHT also showed a significant positive correlation with TT (r = 0.487) and DHEAS (r = 0.52).</p><p><strong>Conclusion: </strong>In conclusion, novel androgen derivatives (11-KT and DHT) hold equivalent evidence for the evaluation of women with PCOS as they are raised in women with PCOS as compared to controls. Moreover, they show a good correlation with the standard markers currently used for PCOS.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"2"},"PeriodicalIF":0.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study on the Effectiveness of Unified Protocols for Transdiagnostic Treatment of Emotional Disorders and Modular Cognitive-Behavioral Therapy on Positive and Negative Affect, and Emotional Awareness in Children with Type 1 Diabetes Mellitus.","authors":"Maryam Hashemipoor Zavareh, Mansoureh Bahramipour Isfahani, Ilnaz Sajjadian","doi":"10.4103/abr.abr_239_24","DOIUrl":"https://doi.org/10.4103/abr.abr_239_24","url":null,"abstract":"<p><strong>Background: </strong>This study aims to compare the effectiveness of unified protocols for transdiagnostic treatment of emotional disorders and modular cognitive-behavioral therapy on positive and negative affect and emotional awareness in children with Type 1 Diabetes (T1D).</p><p><strong>Materials and methods: </strong>In this semi-experimental pretest-posttest study, T1D patients enrolled in two experimental groups: unified protocols for transdiagnostic treatment of emotional disorders and modular cognitive-behavioral therapy interventions in a unified process and one control group. After the completion of the therapeutic sessions, all three groups responded to the research questionnaires in the post-test phase and after a two-month follow-up and were compared.</p><p><strong>Results: </strong>The results of the repeated measures analysis of variance showed that the unified protocols for transdiagnostic treatment of emotional disorders and modular cognitive-behavioral therapy interventions had a significant effect on increasing positive affect and emotional awareness, as well as reducing negative affect in children with T1D, and the effects of the treatment remained during the follow-up stage (<i>P</i> < 0.001). A comparison between the two treatments also indicated that the modular cognitive-behavioral therapy intervention had a greater effectiveness in reducing the negative affect variable in the post-test phase compared to the unified protocols for transdiagnostic treatment (<i>P</i> < 0.01). There were no significant differences between the two therapeutic methods in other variables (<i>P</i> > 0.05).</p><p><strong>Conclusions: </strong>Based on these findings, both interventions can be used as useful treatments to improve psychological variables in children with T1D. These results underscore its potential as a potent tool for enhancing the emotional well-being of individuals with this condition, thereby contributing to an improved quality of life.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"4"},"PeriodicalIF":0.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the Diagnostic Value of DWIBS in the Diagnosis of Breast Lesions Compared to Dynamic Contrast-Enhanced MRI: A Retrospective Observational Study.","authors":"Maryam Farghadani, Safura Mozafari, Maryam Riahinejad, Mashid Haghighi, Reza Eshraghi Samani, Amir Mohammad Taravati, Koushan Rostami, Seyedeh Ghazal Shahrokh, Arezoo Sadeghian","doi":"10.4103/abr.abr_283_24","DOIUrl":"https://doi.org/10.4103/abr.abr_283_24","url":null,"abstract":"<p><strong>Background: </strong>Diffusion-weighted imaging with background body signal suppression (DWIBS) is a new imaging tool for the diagnosis of breast lesions. This study aims to compare DWIBS with contrast-enhanced magnetic resonance imaging (CE-MRI) sequences.</p><p><strong>Materials and methods: </strong>Eighty consecutive patients underwent both CE-MRI and DWIBS images. DWIBS was assessed qualitatively and quantitatively using the apparent diffusion coefficient mapping. A threshold of 1.44 × 10^-3 mm²/s was considered as a cutoff value between malignant and benign lesions. CE-MRI images were evaluated based on a combination of kinetic and morphological information and reported using Breast Imaging Reporting and Data System lexicon. Statistical analysis was performed for both sequences based on pathologic findings as a gold standard.</p><p><strong>Results: </strong>Fifty-five out of 80 lesions (69%) were benign, and 25 malignant lesions (31%) have been reported. The sensitivity, specificity, positive predictive value, and negative predictive value for CE-MRI were 100, 38, 42, and 100%, respectively, and those for DWIBS were 77, 70, 53, and 87%, respectively. By comparing DWIBS and CE-MRI data, no statistically significant difference was reported.</p><p><strong>Conclusion: </strong>DWIBS can be used as an effective alternative for breast CE-MRI in cases of contradictions of IV contrast injection.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"6"},"PeriodicalIF":0.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Densitometric Analysis using Cone Beam Computed Tomography (Cone Beam CT) and Computed Tomography (CT): Establishing the Correlation between Predicted and Actual Values.","authors":"Rashmit Kumar, Kurian Punnoose, Meenakumari Chikkanna, Srikanth Gunturu, Mosa Mohammad Alrifai, Abdulghani Saeed Al Zahrani, J Suresh Babu, C Swarnalatha, Abhishek Singh Nayyar","doi":"10.4103/abr.abr_313_24","DOIUrl":"https://doi.org/10.4103/abr.abr_313_24","url":null,"abstract":"<p><strong>Background: </strong>One of the major drawbacks of cone beam computed tomography (cone beam CT) is that unlike CT, the gray density values obtained from cone beam CT are relative, and not absolute as obtained in the case of CT. The present study was conducted with the intent to perform a comparative bone densitometric analysis using cone beam CT and CT and to determine if there was a mathematical correlation between the two.</p><p><strong>Materials and methods: </strong>The present in-vitro study included CT and cone beam CT scans of 30 dry mandibles wherein the gray density values from well-demarcated, precise anatomical areas were obtained, analyzed, and compared. Also, the dependent <i>t</i>-test and Pearson's correlation coefficient test were used for statistical analysis, while probability values (<i>P</i> values) < 0.05 were contemplated as being statistically significant.</p><p><strong>Results: </strong>Pearson's correlation between the gray density values for different combinations of point(s)/group(s) as derived on CT and cone beam CT images revealed the results to be statistically significant for each of the imaging methods used, individually and when compared in between the two methods, in all the cases (<i>P</i> < 0.001) when analyzed at 5% level of significance.</p><p><strong>Conclusions: </strong>The mean gray density values obtained with cone beam CT were found to be significantly higher than the ones derived from CT in the present study, though, a linear correlation was observed between the values obtained from cone beam CT and CT, which can be used to convert the relative values obtained with cone beam CT into absolute values derived with CT.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"8"},"PeriodicalIF":0.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Acupuncture along with Conventional Therapies on the Treatment of Allergic Rhinitis: A Clinical Trial.","authors":"Sayed Mostafa Hashemi, Farhang Mokhtarinejad, Seyed Mojtaba Abtahi Forooshani, Mehran Rezvani Habibabadi","doi":"10.4103/abr.abr_49_22","DOIUrl":"https://doi.org/10.4103/abr.abr_49_22","url":null,"abstract":"<p><strong>Background: </strong>Acupuncture is one of the most important components of modern complementary medicine. Given its mechanism of action and efficacy, researchers have been recently attracted to address its efficacy in the treatment of allergic rhinitis (AR). Therefore, the present study aimed at evaluating the effect of acupuncture along with conventional therapies on the treatment of AR.</p><p><strong>Materials and methods: </strong>The present randomized, clinical trial was performed on 51 patients with AR. All patients underwent standard AR treatment under the supervision of a specialist physician. Twenty-four patients were treated with acupuncture and 27 patients were considered as the control group. The improvement degree of AR symptoms was evaluated and recorded at baseline, 2 weeks, and 6 weeks after the treatment.</p><p><strong>Results: </strong>The results of this study revealed that a decrease in the runny nose score with a mean of 4.59 ± 3.04 and a decrease in the sneezing score with a mean of 5.30 ± 2.92 were significantly more than those of the control group with a means of 2.85 ± 1.56 and 2.78 ± 1.28, respectively (<i>P</i> value < 0.05). In addition, the frequency of nasal congestion, nasal itching, and tearing was significantly lower in the acupuncture group as compared with the control group (<i>P</i> value < 0.05).</p><p><strong>Conclusion: </strong>According to the results of the present study, although conventional AR treatments can be effective in reducing the symptoms of this disease, the use of acupuncture along with conventional AR treatments has been able to play an effective role in improving and reducing the severity of AR symptoms.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"1"},"PeriodicalIF":0.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Frequency of Clinical and Paraclinical Symptoms in Opium Addicts Hospitalized Due to Lead Poisoning in Isfahan Province.","authors":"Hamid Kalantari, Farzad Gheshlaghi, Marzieh Etezadi","doi":"10.4103/abr.abr_460_23","DOIUrl":"https://doi.org/10.4103/abr.abr_460_23","url":null,"abstract":"<p><strong>Background: </strong>Substance abuse and its consequences are major health hazards in the world. Opium addiction is a common form of substance abuse in Iran. The present study aims to examine the frequency of clinical and paraclinical symptoms of lead poisoning in opium users in the city of Isfahan.</p><p><strong>Materials and methods: </strong>The current study is a cross-sectional study on patients with oral or inhaled consumption of opium or its derivatives, presenting with one of the clinical or laboratory symptoms of lead poisoning. Information related to the age and sex of the patients, duration and manner of opium consumption, clinical symptoms, and laboratory findings of patients were extracted from their files.</p><p><strong>Results: </strong>Three hundred opium user patients poisoned with lead were evaluated. 96.3% of the patients were men. The average age of the participants was 47.67 ± 11.57 years, and the average duration of opium use was 5.34 ± 6.95 years. The most frequent clinical symptom was abdominal pain (98%), followed by constipation (11.33%), nausea (9%), and vomiting (8.33%). 33.3% of people had an increase in AST, 17.1% of people had an increase in ALT, and 88.3% of people had an increase in ALP.</p><p><strong>Conclusion: </strong>We found that the most frequent clinical symptom was abdominal pain. 33.3% of people had an increase in AST, 17.1% of people had an increase in ALT, 88.3% of people had an increase in ALP and, 4% had an increase in creatine. Further studies are recommended.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"7"},"PeriodicalIF":0.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and Perinatal Outcomes in Women with Polycystic Ovary Syndrome Undergoing Artificial Frozen-Thawed Embryo Transfer Cycles: A Retrospective Study.","authors":"Saeideh Dashti, Maryam Eftekhar, Danial Sarikhani, Nasim Tabibnejad","doi":"10.4103/abr.abr_128_24","DOIUrl":"https://doi.org/10.4103/abr.abr_128_24","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a worldwide endocrine disorder of reproductive-aged women. In addition to infertility, PCOS may lead to unfavorable maternal and prenatal outcomes in assisted reproductive technology cycles. The aim of the study was to investigate the risk of adverse maternal and perinatal outcomes using frozen-thawed embryo transfer (FET) among women with and without PCOS.</p><p><strong>Materials and methods: </strong>The data of 1064 women in the PCOS group and 1473 women in the control group were analyzed after FET. Adverse maternal and prenatal outcomes including gestational diabetes mellitus, pre-eclampsia, premature rupture of membranes, preterm birth, low birth weight, and stillbirth were compared between the two groups.</p><p><strong>Results: </strong>We did not find significant differences in the above-mentioned variables between the two groups. Gestational diabetes (7.1% vs. 11%), pre-eclampsia (12% vs. 11.8%), premature rupture of membranes (3.8% vs. 6.5%), preterm birth (13% vs. 15.9%), and low birth weight (10.9% vs. 14.7%) between PCOS and non-PCOS groups, respectively (<i>P</i> > 0.05).</p><p><strong>Conclusions: </strong>Our result showed that there are no differences between PCOS and non-PCOS women undergoing FET regarding maternal and neonatal outcomes.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"3"},"PeriodicalIF":0.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colposcopy Value in Young Child-bearing Women: Is New Recommendations Necessary?","authors":"Fahimeh Sabet, Avishan Aminizad, Fariba Behnamfar, Tajossadat Allameh, Seyedeh Ghazal Shahrokh, Rostami Koushan, Amirmohammad Taravati, Leila Mousavi Seresht","doi":"10.4103/abr.abr_208_23","DOIUrl":"10.4103/abr.abr_208_23","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer is a common malignancy in women and HPV infection is directly linked to it and can be considerably prevented through routine screenings. Despite the belief about the persistence of HPV infection in older than 30-year-old women, high-grade lesions might be detected in younger ages; therefore, the purpose of the current study is to determine the worth of HPV infection screening in younger than 30-year-old women.</p><p><strong>Materials and methods: </strong>This cross-sectional study has been executed on 100 under 30-year-old women who have undergone genotyping. Fourteen HPV subtypes including HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 were defined as high risk and the patients were categorized in HPV 16/18 or other high-risk groups. Pap smear and colposcopy were performed for both groups and interpreted as normal, low-risk and high-risk lesions and compared between the groups.</p><p><strong>Results: </strong>In terms of demographic, clinical, and sexual behavioral characteristics, the present study exhibited similarity (<i>P</i> value > 0.05). Pap smear (<i>P</i> value = 0.100) and colposcopy (<i>P</i> value = 0.711) grading did not differ between those with HPV 16/18 versus other high-risk HPV patients. Pap smear and colposcopic findings were weekly in agreement (<i>κ</i> < 0.5, <i>P</i> value < 0.001).</p><p><strong>Conclusion: </strong>Early cytological plus genotyping assessment in women at early child-bearing ages seems logical, as the cervical premalignant lesions have a slow progressing nature and can be easily treated in early stages.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"119"},"PeriodicalIF":0.7,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}