Advanced biomedical research最新文献

{"title":"Investigating Factors Associated with the Occurrence of Atrial Fibrillation after Non-cardiothoracic Surgery.","authors":"Alireza Nematollahi, Parvin Bahrami, Mahshid Farshidnejad","doi":"10.4103/abr.abr_386_23","DOIUrl":"10.4103/abr.abr_386_23","url":null,"abstract":"<p><strong>Background: </strong>Although the occurrence of atrial fibrillation (AF) after cardiac and thoracic surgery is common and leads to serious complications such as patients' vital organ dysfunction, pulmonary edema, myocardial infarction, and death, evidence about the occurrence and risk factors associated with post-operative atrial fibrillation (POAF) as new AF immediately after non-cardiac thoracic surgery is limited. Therefore, the present study aimed at investigating the factors related to the occurrence of POAF after non-cardiothoracic surgery.</p><p><strong>Materials and methods: </strong>The present retrospective study was conducted on 272 patients undergoing non-cardiothoracic surgeries during 2007-2020. Patients' basic and clinical information including age, sex, BMI, addiction, comorbidities, history of non-cardiac thoracic surgery, history of cardiac surgery, history of chronic kidney disease (CKD), history of ischemic heart disease (IHD), history of heart failure (HF), valvular heart disease (VHD), and the occurrence or non-occurrence of POAF was extracted from their records and then documented.</p><p><strong>Results: </strong>In the present study, 48.1% and 51.9% of patients were with and without POAF, respectively. Risk factors associated with increasing the odds of POAF occurrence included age (OR = 1.094), anemia (OR = 3.947), IHD (OR = 4.23), CKD (OR = 4.765), VHD (OR = 4.781), pulmonary diseases (OR = 7.828), hypertension (HTN) (OR = 8.336), HF (OR = 11.790), and post-thoracic surgery (OR = 49.072) (<i>P</i>-value < 0.05).</p><p><strong>Conclusion: </strong>According to the results of the present study, aging, comorbidities (i.e., anemia, pulmonary diseases, HTN, and CKD), heart diseases (i.e., IHD, VHD, and HF), and post-thoracic surgery were among the most significant risk factors associated with the increased occurrence of POAF.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"49"},"PeriodicalIF":1.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Impact of Laryngoscopy on Hemodynamic Status and the Neutrophil-to-Lymphocyte Ratio after Induction of Anesthesia with Etomidate, Propofol, and Ketamine.","authors":"Saied Morteza Heidari, Behzad Nazemroaya, Peyman Farhanian","doi":"10.4103/abr.abr_310_24","DOIUrl":"10.4103/abr.abr_310_24","url":null,"abstract":"<p><strong>Background: </strong>The neutrophil-to-lymphocyte ratio (NLR) is one of the prognostic factors reflecting the balance between systemic inflammation and immunity in the body. This study aimed to compare the impact of laryngoscopy on hemodynamic status and NLR after induction of anesthesia with etomidate, propofol, and ketamine.</p><p><strong>Materials and methods: </strong>This triple-blind, prospective clinical trial was conducted in 2022 on 90 laryngoscopy candidates. The patients were assigned to three groups of 30. For anesthesia, 0.3 mg/kg of etomidate in the first group, 2.5 mg/kg propofol in the second group, and 2 mg/kg of ketamine in the third group were injected slowly, and the patient underwent ventilation with 100% oxygen for at least 3 minutes; then, laryngoscopy, followed by intubation, was carried out. Blood samples were collected before intubation, immediately after recovery, 20 minutes later, 1 hour later, and at the end of recovery and transmitted to the laboratory.</p><p><strong>Results: </strong>Changes in systolic blood pressure (<i>P</i> = 0.02), diastolic blood pressure (<i>P</i> < 0.01), and mean arterial pressure were significantly higher in the propofol group (<i>P</i> = 0.01). The heart rate (<i>P</i> = 0.56) and oxygen saturation level (<i>P</i> = 0.62) were similar between the three groups. Changes in the mean lymphocyte (<i>P</i> < 0.001) as well as changes in the NLR (<i>P</i> < 0.001) were significantly higher in the ketamine group (<i>P</i> < 0.001). Changes in the neutrophil mean values showed no significant differences (<i>P</i> = 0.24) as the incidence of complications, such as nausea, vomiting, and headache in the three groups.</p><p><strong>Conclusion: </strong>The present study indicated that etomidate had hemodynamic stability and reduced changes in the mean values of lymphocyte, neutrophil, and NLR compared to ketamine and propofol.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"58"},"PeriodicalIF":1.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Diagnostic Value of Ultrasound and Rotterdam CT Scoring Criterion Used for Measuring Optic Nerve Sheath Diameter in the Prognosis of the Mortality and Disability Level of Patients with Head Trauma.","authors":"Farhad Heydari, Mohammad Nasr-Esfahani, Mehrdad Esmailian, Mohsen Salemi","doi":"10.4103/abr.abr_66_24","DOIUrl":"10.4103/abr.abr_66_24","url":null,"abstract":"<p><strong>Background: </strong>Considering that the measurement of optic nerve sheath diameter (ONSD) can be easily performed by ultrasound, and previous studies have addressed its possible association with brain damage, the very aim of the present study was to compare the diagnostic value of ultrasound and Rotterdam CT scoring (RCTS) criterion used for measuring ONSD in the prognosis of the mortality and disability level of patients with head trauma.</p><p><strong>Materials and methods: </strong>The prospective cohort study was performed on 142 patients with traumatic brain injury (TBI). CT scan was performed for all patients, and the results were recorded. However, the average ONSD values for both eyes were measured using ultrasound and recorded. Moreover, the patient's level of disability and outcome were evaluated and recorded based on the RCTS classification and the Glasgow coma scale.</p><p><strong>Results: </strong>The diagnostic value of RCTS had the cut-off value of greater than 2 in the prognosis of patients' mortality (sensitivity: 76.92% and specificity: 73.28%) and the cut-off value of greater than 2 in the prognosis of patients' disability level (sensitivity: 80.39% and specificity: 89.01%)(<i>P</i> value < 0.001). The ONSD value had a cut-off value > 6.9 mm in the prognosis of disability level (sensitivity: 68.63% and specificity: 82.42%) and had a cut-off value >6.8 mm in the prognosis of mortality (sensitivity: 88.46% and specificity: 40.52%) (<i>P</i> value < 0.001).</p><p><strong>Conclusion: </strong>According to the results of the present study, both RCTS and ONSD had an acceptable diagnostic value in the prognosis of the mortality and disability level of patients with TBI.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"51"},"PeriodicalIF":1.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicoradiological Findings of COVID-19-Associated Mucormycosis in a Referral Tertiary Care.","authors":"Somayeh Haji Ahmadi, Ali Zokaei, Seyyed-Ali Alaei, Kiana Shirani, Rasoul Mohammadi, Mohammad Amin Najafi","doi":"10.4103/abr.abr_372_24","DOIUrl":"10.4103/abr.abr_372_24","url":null,"abstract":"<p><strong>Background: </strong>Mucormycosis, an opportunistic fungal infection, has surged during the COVID-19 pandemic, especially with the delta variant, due to factors like steroid use and diabetes. This study examines radiological features through computed tomography (CT) and magnetic resonance imaging (MRI) findings in COVID-19-associated mucormycosis (CAM) patients.</p><p><strong>Materials and methods: </strong>This single-center cross-sectional study conducted between March 2021 and March 2022 at a tertiary care center involved COVID-19 patients over 18 diagnosed with mucormycosis through pathological and endoscopic findings. Paranasal CT scans and brain, sinus, and orbit MRIs were performed to assess various involvements, including sinus, retroantral fat, intraorbital, and bone status, as well as cavernous sinus, internal carotid artery, superior ophthalmic vein, superior ophthalmic fissure, and intraparenchymal brain involvement. Demographic and clinical data, including medical history and laboratory findings, were collected. Statistical analysis using independent t-tests, Chi-squared tests, Fisher's exact test, and logistic regression was conducted with a significance threshold of <i>P</i> < 0.05.</p><p><strong>Results: </strong>This study of 54 CAM patients in Isfahan, Iran, found a high prevalence of diabetes (68.5%) and a 24.1% mortality rate. Imaging revealed significant sinonasal (87%), brain (35.2%), and intraorbital (60%) involvement. Chest CT scans showed predominant ground glass opacity (96.3%) and lower-zone lung involvement.</p><p><strong>Conclusion: </strong>This cross-sectional study underscores the critical role of imaging in diagnosing and managing CAM. Paranasal CT and MRI scans revealed extensive sinonasal, brain, and intraorbital involvement, essential for guiding surgical interventions.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"57"},"PeriodicalIF":1.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of High-Intensity Focused Ultrasound in Urinary and Fecal Symptoms Caused by Rectocele and Cystocele.","authors":"Maryam Hajhashemi, Tahereh Khalili, Minoo Movahedi, Shiva Taheri","doi":"10.4103/abr.abr_183_24","DOIUrl":"10.4103/abr.abr_183_24","url":null,"abstract":"<p><strong>Background: </strong>High-intensity focused ultrasound (HIFU) has received increasing interest and application as a noninvasive modality for the local treatment of solid tumors. In this study, we aim to evaluate the efficacy of HIFU in rectocele and cystocele.</p><p><strong>Materials and methods: </strong>This clinical trial study was conducted on patients who have symptomatic grade 1 and 2 rectocele and cystocele. All patients randomized in two groups; one received HIFU therapy, and the other group underwent Kegel exercises on a daily basis. All patients were followed 2 and 6 months after intervention. The efficacy of HIFU therapy and Kegel exercises were measured based on the pelvic floor discomfort index questionnaire (PFDI-20) and Female Sexual Function Index (FSFI).</p><p><strong>Results: </strong>Both Kegel exercises and HIFU improved the scores of all sections of FSFI and PFDI questionnaires (<i>P</i> value < 0.05) significantly. Our data in comparison of Kegel exercises versus HIFU therapy showed no significant difference.</p><p><strong>Conclusion: </strong>Our data showed good results in both sexual function and urinocolorectal symptoms after HIFU therapy.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"54"},"PeriodicalIF":1.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selumetinib Inhibits T-Acute Lymphoblastic Leukemia Cell Proliferation by Inducing Apoptosis, Inhibiting Autophagy, and Modulating Reactive Oxygen Species Pathway.","authors":"Faeze Bagherifar, Javad Ahmadi, Pejman Hamedi-Asl, Sepide Shakeri, Amir Ayatollahi, Hussein Ayatollahi","doi":"10.4103/abr.abr_422_24","DOIUrl":"10.4103/abr.abr_422_24","url":null,"abstract":"<p><strong>Background: </strong>Early relapse and a poor prognosis are standard features of T-acute lymphoblastic leukemia (T-ALL), a hematological malignancy that presents significant treatment challenges. Glucocorticoids (GCs) are the first line of treatment for T-ALL; nevertheless, GC resistance may develop in patients with newly diagnosed and recurrent T-ALL due to abnormalities in apoptotic pathways. Here, we investigated the impact of the targeted medication, selumetinib, on the expression of proteins that regulate apoptosis in malignant T-ALL cells. We examined the Bcl-2, Bax, P53, Beclin1, and NFE2L2 expression levels as proteins directly or indirectly regulating the apoptosis pathway.</p><p><strong>Materials and methods: </strong>Jurkat cells were treated with different concentrations of selumetinib. Cell viability and IC50 values were measured using the Alamar Blue assay. Gene expression profiles of Bcl-2, Bax, P53, Beclin1, and NFE2L2 were assessed using real-time PCR.</p><p><strong>Results: </strong>The results revealed that selumetinib significantly increased P53, Bax gene expression (<i>P</i> < 0.05), and Bax/Bcl-2 ratio in a time- and dose-dependent manner. A significant decrease was also observed in Beclin1 and NFE2L2 expression (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The study presented here showed that selumetinib at higher doses induced Bax and P53 expression levels and did not affect Bcl-2 in Jurkat cells. This suggests that selumetinib may significantly induce apoptosis in apoptosis-defective T-ALL cells. Moreover, at lower doses, by reducing the expression of Beclin1 and NFE2L2, selumetinib may inhibit the autophagy-dependent survival pathway and induce apoptosis through increasing ROS in patients with newly diagnosed or relapsed ALL, respectively.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"62"},"PeriodicalIF":1.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary Artery Bypass Grafting Using Two Different Anesthetic Techniques: Postoperative Outcome.","authors":"Mojtaba Mansouri, Gholamreza Massoumi, Mohsen MirMohammad-Sadeghi, Amir Mir-Mohammad Sadeghi, Mehdi Shafizadeh","doi":"10.4103/abr.abr_192_24","DOIUrl":"10.4103/abr.abr_192_24","url":null,"abstract":"<p><strong>Background: </strong>This study was performed to investigate the effect of prescribing remifentanil, along with paracetamol and gabapentin in comparison of fentanyl and morphine, on pain relief and faster recovery of patients undergoing coronary artery bypass graft (CABG).</p><p><strong>Materials and method: </strong>A double-blind controlled randomized clinical trial study was performed on 60 CABG candidates. In the control group, the patients underwent anesthesia drugs, analgesic drugs (fentanyl and morphine), and muscle relaxant drugs (without premedication with paracetamol, gabapentin, and remifentanil). In the intervention group, in addition to the control group medications, and bolus doses of remifentanil were used as an analgesic during the operation if analgesia was needed. Also, gabapentin 300 mg orally 1 h before surgery; gabapentin 300 mg every 8 h in the ICU; paracetamol 1 g as an intravenous infusion 30 min before the induction of anesthesia; Paracetamol 1 g every 6 h in the ICU for 3 days were prescribed.</p><p><strong>Results: </strong>The pain scores mean in the intervention group on the first, second, and third days after CABG were significantly lower than the control group (<i>P</i> < 0.05). Also, the percentage of delirium in the control group was significantly higher than the intervention group in the first and second days after CABG (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>According to the results, administration of remifentanil as a short-acting intraoperative opioid, and the gabapentin to treat nerve pain along with paracetamol before and after CABG surgery could effectively control pain and hemodynamic stability of patients with the least side effects besides reducing the need for additional opioids.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"52"},"PeriodicalIF":1.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>IGF2</i> DMR0 Hypomethylation in Peripheral Blood Mononuclear Cells: A Noninvasive Prognostic Biomarker for Colorectal Cancer.","authors":"Elham Zare, Mozhdeh Saghaei, Meysam Mosallaei, Hassan Mehrad-Majd, Ali Beheshti Namdar","doi":"10.4103/abr.abr_481_25","DOIUrl":"10.4103/abr.abr_481_25","url":null,"abstract":"<p><strong>Background: </strong>Conventional colorectal cancer (CRC) screening methods are hindered by invasiveness and insufficient accuracy, emphasizing the need for noninvasive biomarkers. DNA methylation alterations occur early in tumor development, and hypomethylation of the <i>IGF2</i> DMR0 region disrupts normal imprinting, leading to IGF2 overexpression and subsequent tumor progression. Given that peripheral blood mononuclear cells (PBMCs) not only provide an indirect source of biomarkers but also mirror the methylation profile of tumor cells, we evaluated IGF2 DMR0 methylation in PBMCs from Iranian CRC patients and healthy controls.</p><p><strong>Materials and methods: </strong>PBMCs were isolated from peripheral blood specimens obtained from 62 sporadic CRC participants and 62 healthy individuals. The quantitative methylation analysis of the <i>IGF2</i> DMR0 region was conducted using the methylation quantification endonuclease-resistant DNA (MethyQESD) method.</p><p><strong>Results: </strong>The methylation level of <i>IGF2</i> DMR0 was found to be lower in CRC patients (21.44 ± 16.77%) compared to controls (24.63 ± 16.27%); however, this observed disparity did not reach statistical significance (<i>P</i>: 0.286). When stratified by tumor stage, early-stage tumors (Stages I and II) showed significantly higher methylation levels than advanced-stage tumors (Stages III and IV) (<i>P</i> < 0.001). Furthermore, Pearson correlation analysis discovered a significant negative association between tumor size and methylation level (r: -0.624, <i>P</i> < 0.001). No remarkable correlations were identified between methylation levels and other parameters such as gender, age, tumor location, or smoking status (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>Our findings proposed that hypomethylation of the <i>IGF2</i> DMR0 region is meaningfully linked with tumor progression and growth, underscoring its potential as a noninvasive prognostic biomarker for CRC.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"64"},"PeriodicalIF":1.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Ocular Residual Astigmatism on Visual and Refractive Outcomes Following Photorefractive Keratectomy.","authors":"Alireza Peyman, Amir Sadeghi, Mohammad Ghoreishi, Ali-Akbar Mortazavi, Pegah Noorshargh, Mohsen Pourazizi","doi":"10.4103/abr.abr_83_24","DOIUrl":"10.4103/abr.abr_83_24","url":null,"abstract":"<p><strong>Background: </strong>The aim of the study was to evaluate the impact of ocular residual astigmatism (ORA) on refractive and visual outcomes following photorefractive keratectomy (PRK) in myopic astigmatism patients.</p><p><strong>Materials and methods: </strong>This analytical cross-sectional study was performed on patients who underwent PRK. Patients were evaluated for refractive error, visual acuity, and keratometry before and six months after surgery. To calculate the ORA, vectorial differences between corneal plane refractive astigmatism and keratometric astigmatism were established.</p><p><strong>Results: </strong>Two hundred and six eyes from 206 patients including 117 females (56.8%), with a mean age of 32.32 ± 7.03 years were enrolled. The mean ORA was 0.79 ± 0.35 D. There was a negative correlation between cylinder magnitude (r = -0.24, <i>P</i> = 0.002), percentage of success of astigmatism surgery (r = -0.17, <i>P</i> = 0.01), and ORA. Patients with against-the-rule (ATR) astigmatism had high ORA (<i>P</i> = 0.01). The mean age was higher in patients with a high ORA; however, these differences did not reach a significant level (<i>P</i> = 0.07).</p><p><strong>Conclusion: </strong>We found comparable visual outcomes between eyes with low and high ORA that were treated with PRK. Patients with ATR astigmatism had more ORA and the success of astigmatism surgery was lower in patients with a higher ORA.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"50"},"PeriodicalIF":1.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Anti-Mullerian Hormone Levels after Laparoscopic Salpingectomy or Laparoscopic Salpingostomy in Tubal Ectopic Pregnancy.","authors":"Safoura Rouholamin, Maryam Hashemi, Najmeh Andideh","doi":"10.4103/abr.abr_298_22","DOIUrl":"10.4103/abr.abr_298_22","url":null,"abstract":"<p><strong>Background: </strong>The present study aimed to evaluate and compare the effect of salpingectomy and salpingostomy on ovarian reserve through measuring serum levels of anti-Mullerian hormone (AMH).</p><p><strong>Materials and methods: </strong>The current cross-sectional study was conducted on 64 patients with ectopic pregnancy (EP) and stable clinical conditions that required laparoscopic surgery. Serum levels of AMH were measured and compared in patients before and three months after laparoscopic surgery.</p><p><strong>Results: </strong>There was no significant relationship between AMH after surgery with maternal age, gestational age, number of pregnancies, and BHCG (<i>P</i> value > 0.05). In addition, the mean of postoperative AMH level in the salpingostomy group was significantly higher than the salpingectomy group (3.27 ± 1.44 vs. 2.80 ± 1.47; <i>P</i> value < 0.05). There was no significant difference between the mean levels of AMH before and three months after surgery in both salpingectomy and salpingostomy groups (<i>P</i> value > 0.05).</p><p><strong>Conclusion: </strong>Laparoscopic salpingostomy and salpingectomy did not change ovarian reserve assessed through measuring AMH levels in patients with EP.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"61"},"PeriodicalIF":1.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}