Advanced biomedical research最新文献

{"title":"The Association between Triglycerides to High-density Lipoprotein Cholesterol (TG/HDL-C) Ratio and 10-year Prospective Risk of Type 2 Diabetes Mellitus: Yazd Healthy Heart Project.","authors":"Mohammad Poorebrahimi, Seyed Reza Mirjalili, Sepideh Soltani, Pedro Marques-Vidal, Seyedeh Mahdieh Namayandeh, Mohammadtaghi Sarebanhassanabadi","doi":"10.4103/abr.abr_221_25","DOIUrl":"https://doi.org/10.4103/abr.abr_221_25","url":null,"abstract":"<p><strong>Background: </strong>Although the link between dyslipidemia and type 2 diabetes mellitus (T2DM) is well-established, the predictive value of the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio remains unclear. Most existing evidence comes from East Asian populations, highlighting the need for data from more diverse groups. This study investigates the association between TG/HDL-C ratio and T2DM risk in a broader population and aims to identify a practical cut-off point for predicting T2DM incidence.</p><p><strong>Materials and methods: </strong>Cohort study using data from the Yazd Healthy Heart Project (YHHP). Two thousand people aged 20 to 74 were followed for an average of 9.9 years. After excluding individuals with diabetes and missing data, 1,107 participants remained. Multivariate Cox proportional hazard models were applied to examine the relationship between TG/HDL-C ratio and T2DM incidence.</p><p><strong>Results: </strong>In the crude analysis, individuals in the highest quartile of TG/HDL-C ratio had a higher risk of T2DM compared to the lowest quartile, with hazard ratios (HR) of 2.52 (95% CI: 1.33-4.70) in males and 4.05 (95% CI: 2.17-7.57) in females. Adjusted HRs for the highest quartile versus lowest were 1.28 (95% CI: 0.45-3.57) in males and 6.74 (95% CI: 1.43-31.8) in females, with a significant trend in females (<i>P</i> = 0.018) but not in males (<i>P</i> = 0.080). A TG/HDL-C ratio ≥2.46 showed good sensitivity and specificity for predicting T2DM.</p><p><strong>Conclusions: </strong>Increased TG/HDL-C ratio was associated with higher risk of new-onset T2DM, especially in females, supporting its potential role as a biomarker for T2DM risk.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"16"},"PeriodicalIF":1.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained Lung Inflation in Preterm Infants with Signs of Respiratory Distress: A Randomized Controlled Trial.","authors":"Majid Mohammadizadeh, Mehrnaz Moeini, Behzad Barekatain","doi":"10.4103/abr.abr_526_23","DOIUrl":"https://doi.org/10.4103/abr.abr_526_23","url":null,"abstract":"<p><strong>Background: </strong>The role of sustained lung inflation (SI) in neonatal resuscitation at birth as a substitute for, or an adjuvant to positive pressure ventilation (PPV) has been previously examined. This study was conducted to examine the effect of applying SI in preterm infants, who did not need PPV at birth but showed signs of respiratory distress within the first minutes of life, on their mortality and some common morbidities.</p><p><strong>Materials and methods: </strong>In this double-blind randomized clinical trial, seventy-four preterm infants with gestational age 28-33 6/7 weeks and birth weight more than 1000 g in whom signs of respiratory distress appeared within five to ten minutes after birth were randomly assigned to receive nCPAP alone (nCPAP-only group) or a 10-second sustained inflation with 20 cmH₂O pressure followed by nCPAP (SI group).</p><p><strong>Results: </strong>The need for surfactant administration was significantly less (<i>P</i> = 0.003) and the length of hospital stay was significantly shorter in the SI group (<i>P</i> = 0.005), but the duration of nCPAP was significantly longer in this group (<i>P</i> = 0.003). There was no statistically significant difference between the two groups in terms of the need for and duration of mechanical ventilation and also, other secondary outcomes.</p><p><strong>Conclusions: </strong>Applying SI within the first minutes after birth in preterm infants with early signs of respiratory distress can reduce the need for exogenous surfactant and the length of hospital stay. Further studies on the role of this modality in the management of RDS in neonates, especially its effect on long-term cardiopulmonary and neurodevelopment outcomes, are recommended.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"10"},"PeriodicalIF":1.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study of the Effect of Novel Dual Trigger and Delayed HCG With Dual Trigger in Poor Responder Poseidon Group 4 Patients in Antagonist IVF Cycles.","authors":"Elham Naghshineh, Farnoosh Farahbod, Hatav G Tehrani, Ferdous Mehrabian","doi":"10.4103/abr.abr_286_25","DOIUrl":"https://doi.org/10.4103/abr.abr_286_25","url":null,"abstract":"<p><strong>Background: </strong>Decreased Ovarian Reserve (DOR) is a significant challenge in infertility treatment. This study, which compared the effects of Novel Dual Trigger and Delayed Human Chorionic Gonadotropin (HCG), holds promise for improving IVF outcomes.</p><p><strong>Materials and methods: </strong>This was a randomized, double-blinded clinical trial on 90 infertile women. An antagonist regimen was used, which included approximately 300 units of gonadotropins, consisting of 150 units of Human menopausal gonadotropin (hMG) and 150 units of Synal-F. After administering a dose of Strotide injection followed by Decapeptyl and Ovitrelle injections, 12 hours later, a single HCG 5000-unit injection was administered, and 36 hours later, the puncture procedure was performed.</p><p><strong>Results: </strong>Although the frequency of chemical pregnancy, Implantation rate, and ongoing pregnancy was higher in the Novel double trigger with delayed HCG group, and the frequency of zero oocytes and fetus was lower in this group, this difference was not statistically significant.</p><p><strong>Conclusion: </strong>This study showed that using Novel Dual Trigger and Delayed HCG, compared to Dual Trigger, did not significantly differ in the number of oocytes, embryos, or secondary pregnancy outcomes. These findings suggest that the Novel Dual Trigger and Delayed HCG methods could be equally effective in improving IVF outcomes for poor responder patients, providing a potential alternative for ovarian stimulation in these cases and instilling optimism for the future of IVF treatments.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"3"},"PeriodicalIF":1.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12970769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the 5-Year Incidence of Dyslipidemia in the Obese and Nonobese Adult Population: Results of the Yazd Health Study (YaHS).","authors":"Parisa Peigan, Masoud Mirzaei, Pedro Marques-Vidal, Mohammadtaghi Sarebanhassanabadi","doi":"10.4103/abr.abr_140_25","DOIUrl":"https://doi.org/10.4103/abr.abr_140_25","url":null,"abstract":"<p><strong>Background: </strong>Dyslipidemia is a disease and conditions associated with obesity, which is a chronic health problem. The study aimed to determine the 5-year incidence of dyslipidemia in obese and nonobese participants in Central Iran.</p><p><strong>Materials and methods: </strong>Using multistage cluster sampling, 9964 participants aged 20-70 years in Yazd, Iran, were recruited between 2014 and 2015. Those with dyslipidemia were excluded, and nondyslipidemia individuals were included in the study. After a 5-year follow-up, the obese and nonobese participants were evaluated for incident dyslipidemia. We used logistic regression to estimate the 5-year incidence rates of dyslipidemia.</p><p><strong>Results: </strong>During the study's follow-up, dyslipidemia was diagnosed in 4.4% of participants (n = 355). The increase in the incidence of dyslipidemia in obese women was 86.1% (179 people) more than in obese men, with 32.7% (n = 48). The adjusted odds ratios (ORs) (95% confidence intervals [CIs]) for dyslipidemia in obese men and women were 1.32 (0.90-1.94) and 2.81 (1.78-4.43). The results of the logistic regression analysis showed that obesity was associated with a higher risk of dyslipidemia in the participants after adjusting for confounding factors. However, there was no difference in the findings between those under 60 and those over 60.</p><p><strong>Conclusions: </strong>The cohort study indicated that during a 5-year period, obesity was linked to a higher incidence of dyslipidemia in the adult population. Thus, by combining effective policies with obesity prevention initiatives, it is possible to reduce the incidence of dyslipidemia, cardiovascular illnesses, and the mortality associated with these conditions.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"6"},"PeriodicalIF":1.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12970758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and Opportunities in the Development of Dengue Vaccines: A Comprehensive Review.","authors":"Razieh Moghadasi, Yasaman Yadollahi Fars, Hamid Nasri, Mahnaz Momenzadeh","doi":"10.4103/abr.abr_643_24","DOIUrl":"https://doi.org/10.4103/abr.abr_643_24","url":null,"abstract":"<p><p>The dengue virus is the cause of dengue fever, a disease that is prevalent in many regions around the world. Dengue fever is a significant public health concern, particularly in tropical and subtropical areas. The virus has four distinct serotypes and is transmitted to humans through the bites of infected Aedes mosquitoes, which can result in potentially fatal infections. There is currently no specific antiviral treatment for this disease; management mainly involves supportive care for those experiencing symptoms. Therefore, prevention is one of the most effective strategies for controlling this infection. The most effective measure for preventing the disease is vaccination. In recent years, substantial efforts have been made to develop a vaccine effective against all four serotypes of the virus. To date, only one vaccine has been approved, while several others are in phase II and III clinical trials to confirm their efficacy. The development of a dengue vaccine faces several challenges, such as the need for effectiveness against all serotypes, issues related to antibody-dependent enhancement, cross-reactive immune responses, and age-related efficacy limitations. This paper examines the key strategies for vaccine development and the latest advancements in creating an effective dengue vaccine.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"8"},"PeriodicalIF":1.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12970765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing a Vaccine for the Monkeypox Virus Using Immunoinformatics and Structural Tools.","authors":"Razieh Dowran, Behzad Dehghani, Mohammad Javad Rasaee, Mehdi Norouzi, Seyed Mohammad Jazayeri","doi":"10.4103/abr.abr_27_25","DOIUrl":"https://doi.org/10.4103/abr.abr_27_25","url":null,"abstract":"<p><strong>Background: </strong>Monkeypox virus (MPXV) causes mpox, and vaccination is the most effective method of prevention. This project utilized immunoinformatics tools to design a multiepitope subunit vaccine against Mpox.</p><p><strong>Materials and methods: </strong>Seven MPXV antigens (B18R, B21R, D2L, E8L, N3R, I1L, and N2R) were selected based on a literature review, and their sequences were retrieved with the signal peptides and transmembrane domains omitted. B cell, T cell, MHC-I, and MHC-II epitopes were evaluated, followed by tertiary structure and homology modeling. The physicochemical properties of the construct were assessed, molecular docking was conducted with murine Toll-like receptors, and codon optimization was performed.</p><p><strong>Results: </strong>Three sequences were excluded: B18R lacked appropriate epitopes, N2R was predicted to be an allergen by AllergenFP software, and I1L lacked antigenicity. The final vaccine construct incorporated segments from four genes, along with two adjuvants and two T-helper molecules linked by short sequences. The designed protein had a pI of 7.96, a molecular weight of approximately 16 kDa, an energy value of -723.06, a codon frequency distribution of 100, and a codon adaptation index of 0.88. The construct was subsequently cloned and inserted into a pET-28a(+) vector to generate a recombinant plasmid.</p><p><strong>Conclusions: </strong>Using immunoinformatics techniques, a novel multiepitope vaccine construct for MPXV was successfully designed.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"5"},"PeriodicalIF":1.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12970770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Variations in the Diet Quality Index Over Five Years Improve Renal Function and Lipid Profiles Among Patients with Type 2 Diabetes Mellitus? Results from the Prospective Azar Cohort Study.","authors":"Zahra Shahveghar Asl, Faezeh Ghalichi, Elnaz Faramarzi, Alireza Ostadrahimi, Mehrdad Jamali, Zohreh Ghoreishi","doi":"10.4103/abr.abr_197_25","DOIUrl":"https://doi.org/10.4103/abr.abr_197_25","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) is associated with complications, including chronic kidney disease (CKD) and dyslipidemia. This prospective study investigated the longitudinal relationship between changes in diet quality, assessed using the Diet Quality Index-International (DQI-I), and alterations in kidney biomarkers and lipid profiles among patients with T2DM over 5 years.</p><p><strong>Materials and methods: </strong>A cohort of 102 patients with T2DM participated. Diet quality was evaluated at baseline and after 5 years using a validated, 130-item semiquantitative food frequency questionnaire (FFQ). Concurrently, fasting blood samples were collected to measure biomarkers: Fasting blood sugar (FBS), creatinine (Cr), blood urea nitrogen (BUN), glomerular filtration rate (GFR), cholesterol, triglycerides (TG), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL). Regression models analyzed associations between changes in DQI-I scores and changes in these biomarkers.</p><p><strong>Results: </strong>DQI-I scores demonstrated a statistically significant increase over the 5-year period. However, these improvements in diet quality showed no significant association with favorable changes in kidney biomarkers (Cr, BUN, GFR) or lipid profiles (TG, LDL, HDL, cholesterol). The findings indicate that while dietary quality improved, this did not translate into significant effects on lipid metabolism or kidney function parameters.</p><p><strong>Conclusion: </strong>Despite observed improvements in overall diet quality, no significant improvements in lipid profiles or kidney biomarkers were detected. These results underscore the complexity of managing T2DM and its associated complications through dietary modification alone. Future research employing larger sample sizes and extended durations is warranted to elucidate further the long-term impact of dietary changes on renal function and lipid homeostasis in T2DM populations.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"1"},"PeriodicalIF":1.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12970763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal Distribution and Upregulation of Tenascin-C mRNA Expression in the Liver of 90% Hepatectomy Rats are Related to Post-hepatectomy Liver Failure.","authors":"Xinlan Ge, Ke Pan, Qiyue Yang, Lijie Gao, Chonghui Li","doi":"10.4103/abr.abr_325_24","DOIUrl":"https://doi.org/10.4103/abr.abr_325_24","url":null,"abstract":"<p><strong>Background: </strong>Post-hepatectomy liver failure (PHLF) is the most serious complication after extended hepatectomy, with a high perioperative mortality rate. Matricellular protein tenascin-C (TNC) has been related to blood flow change and inflammation. We aimed to explore the hepatic changes of TNC and its relationship with PHLF.</p><p><strong>Materials and methods: </strong>Rats were divided into seven groups: Sham operation, 90% partial hepatectomy (90PH) as a PHLF model, 85% (85PH), and 68% (68PH) hepatectomy without or with lipopolysaccharide (LPS) treatment. The distribution of TNC protein, the mRNA expression of TNC and other endothelial response genes, and the cellular TNC located in the rat livers were evaluated by immunostaining, quantitative real-time polymerase chain reaction, and RNAscope assay.</p><p><strong>Results: </strong>TNC mRNA in the liver tissue was significantly upregulated after hepatectomy and reached the highest level in the 90PH rats compared with those in the 85PH and 68PH rats. This upregulation was closely correlated with the changes of severe liver injury, inhibited liver regeneration, and upregulation of KLF2, ET-1, eNOS, and TM-1 in 90PH rat livers. We found a robust disturbance of hepatic TNC protein distribution in 90PH rat livers with an obvious reduction in hepatic sinusoids but an increase around large blood vessels, which were consistent with the severe liver injury of the 90PH rats. It was also found for the first time that treatment with the endotoxin LPS tremendously exacerbated the above changes of TNC.</p><p><strong>Conclusion: </strong>The distribution and expression of TNC mRNA changed dramatically and contributed to the occurrence of PHLF.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"2"},"PeriodicalIF":1.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12970764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrodermal Activity Responses as Predictor of Physiological and Emotional Responses to Different Visual Stimuli.","authors":"Dindar S Bari","doi":"10.4103/abr.abr_86_24","DOIUrl":"https://doi.org/10.4103/abr.abr_86_24","url":null,"abstract":"<p><strong>Background: </strong>Electrodermal activity (EDA) responses are characterized by fast fluctuations in skin conductance responses (SCRs), skin potential responses (SPRs), and skin susceptance responses (SSRs) triggered by various distinct stimuli. SCRs to various visual stimuli have been investigated in some studies, but not on SSRs and SPRs. This study evaluated the three EDA (SCRs, SSRs, and SPRs) scores to various visual (emotional) stimuli.</p><p><strong>Materials and methods: </strong>EDA responses following five different visual stimuli were recorded from 40 healthy participants (20 male and 20 female) aged in the range 18-25 years (mean 19.75 years) simultaneously recorded at the same skin site. Visual stimuli were funny, sad, scary, nature, and romantic.</p><p><strong>Results: </strong>The obtained results indicated that the different visual stimuli caused significant (<i>P</i> < 0.005) variations in the EDA responses as a result of activation of the sympathetic nervous system and sweat secretion. In addition, the amplitudes of EDA waveforms were higher for funny and scary pictures compared to other pictures.</p><p><strong>Conclusions: </strong>EDA responses could be an important physiological measure, and EDA instruments might be used in diverse psychophysiological applications, including emotion recognition.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"7"},"PeriodicalIF":1.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12970766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorating Effect of <i>Lavandula Angustifolia</i> on Experimental Autoimmune Encephalomyelitis Symptoms by Modulation of Immune Responses.","authors":"Merat Mahmoodi, Abdollah Jafarzadeh, Azita Aghaei, Mahnaz Ramezani, Nahid Zainodini, Farnaz Sedghy, Fatemeh Pouya","doi":"10.4103/abr.abr_511_24","DOIUrl":"https://doi.org/10.4103/abr.abr_511_24","url":null,"abstract":"<p><strong>Background: </strong>Migration of autoreactive T cells into the brain and production of inflammatory cytokines play an undeniable role in the neuronal damage in multiple sclerosis (MS), and its animal model, experimental autoimmune encephalomyelitis (EAE). We investigated the immunomodulatory properties of <i>Lavandula angustifolia</i> (lavender), a medicinal plant, in an EAE model.</p><p><strong>Materials and methods: </strong>EAE was induced in C57BL/6 mice using the MOG35-55 peptide. Mice were divided into control and lavender-treated groups, receiving phosphate-buffered saline or lavender extract (50 or 100 mg/kg), respectively. Clinical symptoms and body weight were recorded throughout the study, and leukocyte infiltration in brain tissues was evaluated postmortem. Lymphocyte proliferation and cytokine production were assessed using MTT and ELISA assays.</p><p><strong>Results: </strong>Lavender-treated mice showed a considerable amelioration in clinical symptoms and weight loss (<i>P</i> < 0.0001), along with reduced brain leukocyte infiltration (<i>P</i> < 0.001). Additionally, lavender extract suppressed autoreactive lymphocyte proliferation (<i>P</i> < 0.01) and decreased levels of IFN-γ (<i>P</i> < 0.0001), IL-6 (<i>P</i> < 0.01 for low dose; <i>P</i> < 0.001 for high dose), and IL-17 (<i>P</i> < 0.05 for low dose; <i>P</i> < 0.01 for high dose). Conversely, TGF-β levels increased significantly in the treated groups (<i>P</i> < 0.0001).</p><p><strong>Conclusions: </strong>Our results cleared the immunomodulatory effects of lavender in the EAE model. Thus, this herb could be a new candidate for the reduction of damage induced by dysregulation of the immune system in MS and similar autoimmune situations.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"15 ","pages":"4"},"PeriodicalIF":1.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12970768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}