Advanced biomedical research最新文献_第2页

Comparative Evaluation of Simplified and Modified Histologic Criteria in the Diagnosis of Chronic Autoimmune Hepatitis. 简化和修改的组织学标准在慢性自身免疫性肝炎诊断中的比较评价。

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Advanced biomedical research Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.4103/abr.abr_294_23

Mohammad H Sanei, Babak Tamizifar, Elahe Mardani, Amir Ghaderi, Elnaz Tarigholeslami, Maryam Sanei

{"title":"Comparative Evaluation of Simplified and Modified Histologic Criteria in the Diagnosis of Chronic Autoimmune Hepatitis.","authors":"Mohammad H Sanei, Babak Tamizifar, Elahe Mardani, Amir Ghaderi, Elnaz Tarigholeslami, Maryam Sanei","doi":"10.4103/abr.abr_294_23","DOIUrl":"https://doi.org/10.4103/abr.abr_294_23","url":null,"abstract":"Background: The present study aimed at comparing simplified and modified histologic criteria alone and along with other indicators in the diagnosis of chronic autoimmune hepatitis (AIH).Materials and methods: In this cross-sectional study, 48 cases were selected from slides and paraffin blocks of patients suspected of chronic AIH according to clinical and laboratory data, including serology and autoantibody findings and viral hepatitis test results. Then, scores equal to 1 (compatible hepatitis), 2 (typical hepatitis), ≤6 (probable hepatitis), and ≥7 (definite hepatitis) were calculated based on the simplified histologic criteria, modified histologic criteria, and these two criteria, along with other indicators including antinuclear antibodies (Ab), smooth muscle Ab or liver-kidney microsomal Ab or soluble liver antigen (Ag) and serum immunoglobulin G (IgG) and absence of viral hepatitis.Results: The results of this study revealed that based on the simplified histologic criteria, 43.8% and 56.3% of these cases were assigned a score of 1 and 2 points, respectively. However, calculating the total score using the simplified criteria along with other indicators showed that 60.4% and 39.6% of cases were assigned a score ≤6 and ≥7 points, respectively. Moreover, the modified histologic criteria indicated that 25% and 75% of cases were assigned a score of 1 and 2 points, respectively.Conclusion: According to the findings of the present study, the modified histologic criteria compared to the simplified histologic criteria identified a higher percentage of patients assigned a score of 2 points. Moreover, modified histologic criteria, along with other indicators, were more accurate in detecting definite AIH (score ≥7 points).","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"21"},"PeriodicalIF":0.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upper Extremity Peripheral Nerve Ultrasonography, as a Diagnostic Aid in Amyotrophic Lateral Sclerosis. 上肢周围神经超声检查在肌萎缩侧索硬化症中的诊断价值。

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Advanced biomedical research Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.4103/abr.abr_399_23

Keivan Basiri, Hanieh Paydari, Fatemeh Abbasi, Behnaz Ansari

{"title":"Upper Extremity Peripheral Nerve Ultrasonography, as a Diagnostic Aid in Amyotrophic Lateral Sclerosis.","authors":"Keivan Basiri, Hanieh Paydari, Fatemeh Abbasi, Behnaz Ansari","doi":"10.4103/abr.abr_399_23","DOIUrl":"https://doi.org/10.4103/abr.abr_399_23","url":null,"abstract":"Background: Amyotrophic lateral sclerosis (ALS) is a life-threatening progressive motor neuron disease whose diagnosis is challenging because of lacking specific diagnostic means. The current study aims to assess the value of upper extremity peripheral nerves ultrasonography in ALS detection.Materials and methods: In this case-control study, 30 ALS subjects were assessed regarding the cross-sectional area (CSA) of the proximal (at distal part of arm or the proximal of elbow) and distal (at wrist level) median and ulnar nerves, assessed via ultrasonography. Similarly, 30 age- and gender-matched healthy controls were evaluated. The receiver operating curve (ROC) was depicted to determine a cut-point for ALS-associated peripheral nerve involvement.Results: Proximal CSA and the proximal-to-distal ratio of the median nerve was remarkably lower in both upper extremities of the ALS subjects compared to the controls (P value < 0.05), while the distal median nerve CSAs did not differ between the groups (P value > 0.05). Distal ulnar nerve CSA in the right hand (P value = 0.007) and the proximal ulnar nerve CSA in the left hand (P value = 0.001) were remarkably lower in the cases than the controls, but the other measurements did not differ (P value > 0.05). There was no significant cut-points to differentiate ALS-affected peripheral nerves from the healthy controls (P value > 0.05).Conclusion: Based on this study, CSA of the proximal median nerve in the cubital fossa seems a rational and valuable means to diagnose ALS; but the distal parts of the median nerve and the ulnar nerve in its all length remained a matter of debate.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"22"},"PeriodicalIF":0.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetic Distress among Patients with Type II: A Descriptive Study. II型糖尿病患者的糖尿病窘迫：一项描述性研究。

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Advanced biomedical research Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.4103/abr.abr_328_24

Mahmoud Mohammed Ahmed, Rian Mahmood Ibrahim, Nasir Muwfaq Younis

{"title":"Diabetic Distress among Patients with Type II: A Descriptive Study.","authors":"Mahmoud Mohammed Ahmed, Rian Mahmood Ibrahim, Nasir Muwfaq Younis","doi":"10.4103/abr.abr_328_24","DOIUrl":"https://doi.org/10.4103/abr.abr_328_24","url":null,"abstract":"Background: Diabetes is a complicated, long-term condition that necessitates difficult patient self-management. This self-management includes regular medication adherence, daily insulin injections for certain patients, and daily decisions about food, exercise, and blood glucose monitoring. The objective of the study was to evaluate diabetic distress in individuals with type II diabetes.Materials and methods: A descriptive cross-sectional study was conducted from February 2024 to May 2024 in a purposive sample of 89 patients attending the outpatient clinic of the Al-Wafia Specialized Center for Diabetes and Endocrinology, a teaching hospital in Mosul. With the help of the literature, a patients' information form containing questions was used to gather data for a questionnaire designed to assess patients' awareness of diabetic distress. The frequencies of the study variables were shown using descriptive statistics. A Chi-square test was used to perform a bivariate analysis. Significant P values were those that were less than 0.05. SPSS, version 25, was used to perform the statistical analyses.Results: The study outcomes showed that, with a mean of 3.636, 39% of the study sample had moderate or high levels of diabetic distress. There was no correlation found between any demographic factor and diabetic distress, except for the participant age (0.190**).Conclusion: This study concluded that among the enrolled 89 diabetic patients most of them had diabetic distress. The statistical association between overall knowledge and sociodemographic variables indicated that there is no statistically significant difference between patients' knowledge and their sociodemographic information, except with the age group.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"23"},"PeriodicalIF":0.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Neutrophil-Activating Protein of Helicobacter pylori on Th Cytokines and Airway Inflammation in Allergic Asthma. 幽门螺杆菌中性粒细胞活化蛋白对变应性哮喘Th细胞因子和气道炎症的影响。

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Advanced biomedical research Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.4103/abr.abr_570_24

Alireza Khaleghi Khorrami, Rasoul Shokri, Seyyed Shamsadin Athari, Sanaz Mahmazi

{"title":"Effects of Neutrophil-Activating Protein of Helicobacter pylori on Th Cytokines and Airway Inflammation in Allergic Asthma.","authors":"Alireza Khaleghi Khorrami, Rasoul Shokri, Seyyed Shamsadin Athari, Sanaz Mahmazi","doi":"10.4103/abr.abr_570_24","DOIUrl":"https://doi.org/10.4103/abr.abr_570_24","url":null,"abstract":"Background: The study conclusively demonstrated that Helicobacter pylori (H. pylori) neutrophil-activating protein (HP-NAP) has the ability to switch a pro-allergic Th2 response to a Th1 response. Furthermore, it investigated the effects of HP-NAP on TH1 and TH2 cytokines, as well as airway inflammation in a rat model of allergic asthma, and compared these effects with those of H. pylori.Materials and methods: H. pylori and HP-NAP were prepared based on a previous study. Sixty male Blab/c mice were used for histopathological and immunological studies, divided into six groups of 10. Five mice from each group were selected for histopathological studies, and five were selected for measuring changes in TH cytokine levels and eosinophil count. The study was conducted over 31 days.Results: Histological staining was performed on six selected groups. After treatment with HP-NAP, the recipient treatment group demonstrated a significant decrease in interleukin (IL)-4, IL-5, and total immunoglobulin E (IgE) levels, along with a significant increase in IL-2 and interferon-gamma (IFN-γ) levels. Furthermore, the number of eosinophils in the bronchoalveolar lavage fluid (BALF) of mice treated with HP-NAP significantly decreased compared to the positive control samples.Conclusion: Our research findings conclude that HP-NAP can significantly reduce serum levels of IgE, IL-5, and IL-4, while increasing levels of IL-2 and IFN-γ, compared to H. pylori. HP-NAP can be a useful therapeutic agent for preventing and treating allergic asthma.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"28"},"PeriodicalIF":0.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bowenoid Papulosis of the Genitalia in an Older Individual: A Case Report. 老年人生殖器鲍氏样丘疹病1例报告。

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Advanced biomedical research Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.4103/abr.abr_286_24

Reza Kazemi, Faezeh Jandaghi, Maryam Derakhshan, Moein Bighamian, Farzaneh Montazeri

引用次数: 0

The Effect of Pre-emptive Dose of Dexamethasone on Pain, Nausea, Frequency of Vomiting, and Postoperative Restlessness in Patients Undergoing Septorhinoplasty: A Randomized Control Clinical Trial Study. 先发制人剂量地塞米松对鼻中隔成形术患者疼痛、恶心、呕吐频率和术后不安的影响：一项随机对照临床试验研究

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Advanced biomedical research Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.4103/abr.abr_84_24

Parvin Sajedi, Amir Mohammad Travati

{"title":"The Effect of Pre-emptive Dose of Dexamethasone on Pain, Nausea, Frequency of Vomiting, and Postoperative Restlessness in Patients Undergoing Septorhinoplasty: A Randomized Control Clinical Trial Study.","authors":"Parvin Sajedi, Amir Mohammad Travati","doi":"10.4103/abr.abr_84_24","DOIUrl":"https://doi.org/10.4103/abr.abr_84_24","url":null,"abstract":"Background: This study was conducted with the aim of determining the effect of pre-emptive dose of dexamethasone on pain, nausea, frequency of vomiting, and restlessness after septorhinoplasty.Materials and methods: In this clinical trial study, 70 patients' candidates for septorhinoplasty were divided into two groups of 35 and before induction of anesthesia, 0.1 mg/kg of dexamethasone was injected intravenously in the first group and the same volume of normal saline in the second group. Postoperative nausea severity and frequency of vomiting, pain intensity, patient restlessness, painkiller, and antinausea medication usage up to 24 hours after surgery were evaluated and compared in two groups.Results: There was a significant difference between the two groups in the mean of pain intensity at the time of recovery (0.031). Also, 6 hours (P = 0.016), 12 hours (P=<0.001), 18 hours (P = 0.013), and 24 (P = 0.009) hours after the operation, the control group had higher pain intensity. In recovery, 9 (28.1%) of the dexamethasone group and 22 (66.7%) of the control group had restlessness (P = 0.002). Severity of nausea from PACU until 24 hours after surgery showed that the dexamethasone group had less nausea at the PACU (P ˂ 0.001); three subjects from this group have vomited and seven subjects from the control group vomited after surgery, and differences were not significant (P = 0.3).Conclusion: Intravenous dexamethasone 0.1 mg/kg before induction of anesthesia reduced the intensity of pain, nausea, restlessness, and the need for painkillers and antinausea drugs, without causing serious hemodynamic disorders. It seems that the use of this drug with the mentioned dose in septorinoplasty patients is associated with a reduction in postoperative complications.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"29"},"PeriodicalIF":0.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Evaluation of Patient-reported Outcomes in Proximal Humeral Fracture: Deltoid-Splitting versus Deltopectoral Approaches. 肱骨近端骨折患者报告结果的比较评价：三角肌裂入路与三角胸肌裂入路。

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Advanced biomedical research Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.4103/abr.abr_457_23

Hasan Barati, Mojtaba Baroutkoub, Sohrab Salimi, Sina Afzal, Farzad Amouzadeh Omrani, Hamid Nikfarjam, Reza Tavakoli Darestani

{"title":"Comparative Evaluation of Patient-reported Outcomes in Proximal Humeral Fracture: Deltoid-Splitting versus Deltopectoral Approaches.","authors":"Hasan Barati, Mojtaba Baroutkoub, Sohrab Salimi, Sina Afzal, Farzad Amouzadeh Omrani, Hamid Nikfarjam, Reza Tavakoli Darestani","doi":"10.4103/abr.abr_457_23","DOIUrl":"https://doi.org/10.4103/abr.abr_457_23","url":null,"abstract":"Background: Proximal humeral fractures (PHF) are common orthopedic injuries often associated with osteoporosis. Surgical approaches for PHF fixation, such as the deltopectoral and deltoid-splitting methods, have been a subject of debate. Additionally, patient satisfaction with these approaches has not been extensively studied among Iranian patients.Materials and methods: A cross-sectional study was conducted on patients treated for PHF at a referral orthopedic center in Tehran, Iran, from 2019 to 2021. Two surgical techniques, deltopectoral and deltoid-splitting, were compared. Patient-reported outcomes in terms of patient satisfaction, including quality of life (SF-36), pain relief (VAS score), and shoulder function (Constant score), were assessed at six- and 12-month intervals postsurgery. Statistical analyses were performed to determine the differences between the two approaches.Results: Among 148 patients, the majority were male (72.3%), 104 (70.3%) and 44 (29.7%) of patients were operated by deltopectoral and deltoid-splitting approaches, respectively. Patients' quality of life scored higher in the deltoid-splitting group both in six and one year following the surgical procedure; however, the observed differences did not reach statistical significance (P values 0.121 and 0.736, respectively). While there were slight variations in shoulder function and pain relief between the surgical approaches, none of these differences reached statistical significance.Conclusion: This study suggests that both deltopectoral and deltoid-splitting surgical approaches for PHF treatment offer comparable patient satisfaction and functional outcomes. Surgeons can consider their expertise and patient-specific factors when selecting the appropriate approach for PHF fixation.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"24"},"PeriodicalIF":0.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Prevalence of Hypomagnesemia and the Related Risk Factors in Patients Admitted to a Referral Heart Hospital in Isfahan. 伊斯法罕一家转诊心脏医院入院患者低镁血症患病率及相关危险因素的评估

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Advanced biomedical research Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.4103/abr.abr_106_24

Mahdi Soudmandi, Mehrnoush Dianatkhah, Mahnaz Momenzadeh, Zahra Teimouri-Jervekani

{"title":"Evaluation of the Prevalence of Hypomagnesemia and the Related Risk Factors in Patients Admitted to a Referral Heart Hospital in Isfahan.","authors":"Mahdi Soudmandi, Mehrnoush Dianatkhah, Mahnaz Momenzadeh, Zahra Teimouri-Jervekani","doi":"10.4103/abr.abr_106_24","DOIUrl":"https://doi.org/10.4103/abr.abr_106_24","url":null,"abstract":"Background: Magnesium is one of the most abundant cations in the body and plays a vital role in the function of the cardiovascular system. Hypomagnesemia can cause severe and dangerous cardiovascular complications. Also, since drugs that can lead to hypomagnesemia are commonly prescribed to cardiac patients, we decided to investigate the prevalence of hypomagnesemia in the population of cardiac patients to be aware of the prevalence of this condition as an important risk factor for cardiovascular events.Materials and methods: This study is a retrospective cross-sectional study of an analytical-observational type with a fundamental-applied approach, in which by recording the information of patients in pre-designed forms, the prevalence of hypomagnesemia in them and also the prevalence of hypomagnesemia separation of different heart diseases and the relationship of hypomagnesemia with age, sex, glomerular filtration rate (GFR), and drugs used have been evaluated.Results: A total of 982 patients were included in the study, of which 636 were men and 346 were women. The average age of the patients in this study was 63 years. Hypomagnesemia was observed in 138 patients (14%), and the prevalence of hypomagnesemia in patients with ventricular arrhythmias was 40%. It was also observed that only 47% of the patients with hypomagnesemia received magnesium, and the rest were not treated.Conclusion: This study highlights the importance of magnesium status and its relationship with various clinical factors in the studied population. This emphasizes the need to increase attention to hypomagnesemia, especially among vulnerable groups such as women and older adults.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"25"},"PeriodicalIF":0.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Prevalence, Survival, and Molecular Type of Breast Cancer Patients with Brain Metastases. 乳腺癌脑转移患者的患病率、生存率和分子类型调查。

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Advanced biomedical research Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.4103/abr.abr_262_24

Amir Aria, Mehran Sharifi, Setayesh Sindarreh

{"title":"Investigation of Prevalence, Survival, and Molecular Type of Breast Cancer Patients with Brain Metastases.","authors":"Amir Aria, Mehran Sharifi, Setayesh Sindarreh","doi":"10.4103/abr.abr_262_24","DOIUrl":"https://doi.org/10.4103/abr.abr_262_24","url":null,"abstract":"Background: This study aims to investigate the factors associated with breast cancer brain metastasis (BCBM) in individuals suffering from breast cancer (BC).Materials and methods: This cross-sectional study conducted on 200 patients with metastatic breast cancer (MBC) including 52 brain and 148 other organ metastases. The demographic, medical, clinical, laboratory, and therapeutic approach characteristics were compared between the groups.Results: Headache (61.5%), weakness and lethargy (26.9%), dizziness (15.4%), blurred vision/blindness (15.4%), and convulsions (15.4%) were the major initial symptoms of BCBM. Radiotherapy (71.2%), injectable (34.6%), and oral chemotherapy (26.9%) were the major applied therapeutic strategies to manage brain metastasis (BM). The overall survival of the patients from cancer diagnosis to death accounted for 33 months (95%CI: 27.52-38.47), while this period after BM diagnosis was limited to 6 months (95%CI: 5.15-6.84). The rate of hormone therapy was remarkably higher among the metastasis in other organs than the brain (P value = 0.005), while targeted therapy was performed in higher rates for BM (P value = 0.001). The evaluation of BC-related tumor markers revealed that human epidermal growth factor 2 (HER2) (P value < 0.001) positivity was remarkably higher among BCBM, while positive estrogen receptor (ER) (P value = 0.004) and progesterone receptor (PR) (P value = 0.013) were statistically more in the other group.Conclusion: Based on the findings of this study, the BC patients with BM had a remarkable short survival, had a higher rate of perineural invasion, and were mostly positive for HER2. Radiotherapy, chemotherapy, and surgery were the most common approaches to these patients.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"26"},"PeriodicalIF":0.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Incidence of Tibial Mal Rotation after Closed Tibial Intra-Medullary Nailing and its Effects on Clinical Outcomes of the Patients: A Prospective Study. 闭式胫骨髓内钉术后胫骨畸形旋转发生率的评估及其对患者临床预后的影响：一项前瞻性研究。

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Advanced biomedical research Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI: 10.4103/abr.abr_355_24

Hamid Mousavi, Alireza Hosseini, Koushan Rostami, Seyedeh Ghazal Shahrokh, Amir Mohammad Taravati, Saeid Jafari, Mojtaba Abuali

{"title":"Evaluation of Incidence of Tibial Mal Rotation after Closed Tibial Intra-Medullary Nailing and its Effects on Clinical Outcomes of the Patients: A Prospective Study.","authors":"Hamid Mousavi, Alireza Hosseini, Koushan Rostami, Seyedeh Ghazal Shahrokh, Amir Mohammad Taravati, Saeid Jafari, Mojtaba Abuali","doi":"10.4103/abr.abr_355_24","DOIUrl":"https://doi.org/10.4103/abr.abr_355_24","url":null,"abstract":"Background: Incidence of tibial malrotation (more than 10° of tibial rotation in comparison with contralateral tibia) following intramedullary fixation originally ranged from 0% to 6% and different complications were reported including: Cosmetic appearance concerns, impaired gait specially crouch gait when more than 30° of malrotation happens, foot adopting a pes planus position.Materials and methods: This prospective study was performed from January 2022 to June 2024. A total of 245 patients with tibial mid-diaphyseal fractures underwent closed intra medullary nailing and basic data including age of the patients, their genders, BMI and surgery durations and post-operative outcome variables including lower extremity functional scale (LEFS), six minute walk test (6 MWT) and SF 36 questionnaire were collected.Results: From 245 of the patients 237 of them were included in the study and basic data including age of the patients, their genders, BMI and surgery durations were not significantly different between two groups (P value > 0.05). Post-operative outcome variables including LEFS, 6 MWT and SF 36 questionnaire was measured and no significant difference between two groups is reported (P value > 0.05).Conclusion: Age, gender, BMI, and surgical time had no meaningful relationship with incidence of tibial malrotation after closed tibial intra medullary nailing. Clinical outcomes are not significantly different between two groups, which it means that tibial torsion will not affect clinical outcomes of the patients.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"19"},"PeriodicalIF":0.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0