Advanced biomedical research最新文献

{"title":"<i>In vitro</i> Investigation of Radiotherapy along with Gemcitabine Loaded PEG Gold Nanoparticles Against MCF-7 Breast Cancer Cells.","authors":"Ali Salarvand, Ahmad Shanei, Seyed Hossein Hejazi, Iraj Abedi, Neda Attaran Kakhki","doi":"10.4103/abr.abr_221_24","DOIUrl":"https://doi.org/10.4103/abr.abr_221_24","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is one of the major causes of cancer death in women. Usually, surgery, chemotherapy, and radiotherapy are commonly used in the treatment of breast cancer, but these methods have significant side effects and low survival rates. By developing combination therapies, side effects can be reduced so that therapeutic efficacy is maintained. The aim of this study was to examine the effects of radiotherapy combined with chemotherapy using combined gem and gold nanoparticle for the treatment of breast cancer.</p><p><strong>Materials and methods: </strong>In this study, PEGylated gold nanoparticles (PEG-GNPs) were synthesized and loaded with an anticancer agent, gemcitabine (Gem-PEG-GNPs). Then, GNPs, PEG-GNPs, and Gem-PEG-GNPs were investigated using several techniques, including UV-Vis, FTIR, DLS, and TEM analysis. After that, the efficacy of the synthesized nanoparticles for chemoradiotherapy was evaluated through <i>in vitro</i> experiments.</p><p><strong>Results: </strong>The prepared Gem-PEG-GNPs act as radiosensitizers and nanocarrier, which increases the effectiveness of radio chemotherapy and reduces side effects. Combining Gem-PEG-GNPs with X-ray irradiation increased apoptosis and decreased survival rates of MCF-7 cells. When Gem-PEG-GNPs and radiation were combined, a significant synergistic effect was observed compared to the effect of radiation alone.</p><p><strong>Conclusion: </strong>Gem-PEG-GNPs can have the potential of an effective and radiosensitizing drug delivery agent against breast cancer therapeutics.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"12"},"PeriodicalIF":0.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the PPP Syndrome: A Rare Combination of Pancreatitis, Panniculitis, and Polyarthritis.","authors":"Amin Bagheri-Ghalehsalimi, Mohammad Jafari, Amir Aria, Athar Kouchak, Mahnaz Momenzadeh","doi":"10.4103/abr.abr_324_24","DOIUrl":"https://doi.org/10.4103/abr.abr_324_24","url":null,"abstract":"<p><p>Pancreatitis, panniculitis, and polyarthritis (PPP) syndrome is a rare but serious disease that can be deadly. Its symptoms come on suddenly and unexpectedly. This disease is identified by erythematous bullous skin lesions and arthritis caused by pancreatic dysfunction. A 25-year-old man had an abdominal trauma with no past medical history. A CT scan showed pancreatic inflammation, peripancreatic edema, and mild fluid in the head of the pancreas without any collection and collection of blood in the retroperitoneum. The patient came back to the hospital 2 weeks later with a fever, abdominal pain, tender joints, redness, warmth in arms and legs, and rash on the skin. In addition, their amylase and lipase levels were increased. Based on the symptoms, the patient was referred to a rheumatologist and diagnosed with PPP syndrome with concomitant pancreatitis, panniculitis, and polyarthritis. Despite being prescribed corticosteroids and broad-spectrum antibiotics, the patient passed away. The exact pathophysiology of the additional abdominal symptoms has not yet been determined. However, some researchers have suggested that this disorder may be due to the entry of pancreatic lipase enzymes into the bloodstream. Pancreatic enzymes damage adipose tissue in the lower extremities and cause panniculitis (subcutaneous adipose tissue inflammation). The symptoms of arthritis may vary depending on the clinical case as different joints are affected and the number and symmetry of joints involved may differ. Therefore, PPP syndrome is sporadic and not easily diagnosed.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"14"},"PeriodicalIF":0.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The <i>in Vitro</i> Antimicrobial Effect of Ethanolic Extracts of Aloe Vera on the H-pylori and Inhibitory Effect of Secondary Metabolites of Aloe Vera by Molecular Docking.","authors":"Roghayeh Farajnabi, Zahra Hojjati Bonab, Neda Shagayegh","doi":"10.4103/abr.abr_141_24","DOIUrl":"https://doi.org/10.4103/abr.abr_141_24","url":null,"abstract":"<p><strong>Background: </strong>Helicobacter pylori is a Gram negative bacterium in the human stomach. Considering the side effects of the drug regimen and the prevalence of antibiotic resistance, in this project, the antimicrobial effect of aloe vera extracts on Helicobacter pylori was tested.</p><p><strong>Materials and methods: </strong>Evaluation of the antimicrobial effect of aloe vera extract on Helicobacter pylori was done using diffusion methods in agar, and the diameter of the nongrowth halo was measured. The molecular interaction between the active ingredients of aloe vera and urease enzyme was investigated with Mulgroo Virtual Docker (MVD) software.</p><p><strong>Results: </strong>The diameter of the halo of no growth at a concentration of 1000 mg/ml in aloe vera was 19 mm, and the maximum diameter of no growth was observed in the ethanolic extract.</p><p><strong>Conclusion: </strong>According to our results, the ethanolic extract of aloe vera can be suggested as a good option as an antimicrobial supplement for Helicobacter pylori.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"10"},"PeriodicalIF":0.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of IGFBP-3 in Human Diseases Relying on Different Cell Signaling Pathways.","authors":"Nima Naseri, Mohammad Reza Mofid","doi":"10.4103/abr.abr_23_23","DOIUrl":"https://doi.org/10.4103/abr.abr_23_23","url":null,"abstract":"<p><p>Insulin growth factor protein 3 (IGFBP-3) is a member of the binding protein family which is known as the main carrier of insulin-like growth factors in human serum. Through the existence of multiple IGFBP-3 binding partners such as insulin growth factors (IGFs), transmembrane receptor 219 (TMEM219) protein, retinoid X receptors (RXRs), and other proteins, in IGF-dependent and IGF-independent cell signaling pathways, IGFBP-3 exerts the various key roles associated with physiological processes such as cell growth prevention and differentiation, apoptosis induction and have several metabolic activities such as regulating blood glucose, lipid metabolism, regulating bone, and chondrocyte growth as well. Moreover, IGFBP-3 plays an important role in the pathophysiology of a variety of human diseases including ischemia, Alzheimer's disease, diabetes mellitus, asthma, and cancer. Therefore, in this current study, we intend to describe the IGFBP-3 role depending on its effect on the pathophysiology of human illnesses.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"15"},"PeriodicalIF":0.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Furosemide's Preventative Role in Contrast-Induced Nephropathy among ST-Segment Elevation Myocardial Infarction Patients undergoing Percutaneous Coronary Intervention.","authors":"Mostafa Ariafar, Parvin Ghorbani, Seyed Masoud Seyedian, Farzaneh Ahamdi, Leila Sabetnia, Elham Farhadi","doi":"10.4103/abr.abr_121_24","DOIUrl":"https://doi.org/10.4103/abr.abr_121_24","url":null,"abstract":"<p><strong>Background: </strong>ST-elevation myocardial infarction (STEMI) is regarded as a risk factor for contrast-induced nephropathy (CIN). Numerous studies have explored preventive measures for CIN such as the use of diuretics. However, the specific impact of diuretics in averting nephropathy remains uncertain. We investigated whether post-treatment with furosemide decreases CIN risk.</p><p><strong>Materials and methods: </strong>We designed a clinical trial and included 234 patients with STEMI undergoing primary percutaneous coronary intervention (PCI). Patients were divided into two groups: Group I (furosemide 0.5 mg/kg) and Group II (control). Serum creatinine and blood urea nitrogen (BUN) were measured pre- and post-surgery. CIN was described as more than either 25% or 0.5 mg/dL induction in serum creatinine from the baseline in 24 h and 72 h post-PCI.</p><p><strong>Results: </strong>CIN occurred in 33 patients (14.1%) in 24 h and 35 patients (14.9%) in 72 h. CIN incidence was not significantly different between both groups. However, BUN was significantly higher in the furosemide group (<i>P</i> < 0.05). Most patients in the furosemide group were men and smokers compared to the control group.</p><p><strong>Conclusion: </strong>A combination of low-dose furosemide plus standard hydration was not correlated with lower CIN incidence in STEMI patients who are candidates for primary PCI compared to standard hydration only. Further studies with a larger sample size in the future are needed to better understand the effects of this combination.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"16"},"PeriodicalIF":0.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Composition, Molecular Docking Analysis, and Biological Properties of <i>Salvia Mirzayanii</i>.","authors":"Rahman Mahdizadehdehosta, Hamid Shahbazmohammadi, Soheila Moein, Nepton Soltani, Kianoosh Malekzadeh, Mahmoodreza Moein","doi":"10.4103/abr.abr_220_24","DOIUrl":"https://doi.org/10.4103/abr.abr_220_24","url":null,"abstract":"<p><strong>Background: </strong>Diabetes is a dangerous metabolic disorder that is becoming more common worldwide. In the present research, we aimed to analyze the chemical composition, <i>in silico</i> molecular docking, and evaluate the biological features of <i>Salvia mirzayanii</i>.</p><p><strong>Materials and methods: </strong>The constituents found in the aqueous extract of <i>S. mirzayanii</i> leaves were identified using gas chromatography-mass spectrometry (GC-MS). The major compounds of <i>S. mirzayanii</i> extract were subjected to molecular docking analysis. Screening for potential antioxidant abilities was conducted using radical scavenging assays. Alpha-amylase and α-glucosidase inhibitory kinetic studies were performed to evaluate the <i>in vitro</i> antihyperglycemic potential of <i>S. mirzayanii</i>. The <i>in vivo</i> function of <i>S. mirzayanii</i> extract was evaluated by examining the gene expression of phosphoenolpyruvate carboxykinase (PEPCK), glucose 6-phosphatase (G6Pase), and glucose transporter-4 (GLUT4) in diabetic rats.</p><p><strong>Results: </strong>The major compounds in aqueous extract of <i>S. mirzayanii</i> were 1,8-cineole (51.6 + 2.7%), linalool acetate (22.0 + 1.9%), a-terpinyl acetate (9.3 + 0.7%), and aromadendrene (5.6 + 0.6). <i>In silico</i> studies indicated that 1,8-cineole was a more potent inhibitor of α-amylase and α-glucosidase enzymes. The liquid extract of <i>S. mirzayanii</i> showed considerable radical scavenging activity against 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and effective inhibition of α-amylase (IC₅₀ = 0.01 ± 0.02) and α-glucosidase (IC₅₀ = 0.11 ± 0.01). The highest antihyperglycemic activity was observed with a 600 mg/kg dose of the plant's aqueous extract.</p><p><strong>Conclusions: </strong>Altogether, our findings show the possibility of applying the aqueous extract of <i>S. mirzayani</i> leaves as a potential therapeutic compound.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"18"},"PeriodicalIF":0.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Analysis of Functional Outcomes between Lateral and Posterolateral Approaches in Total Hip Arthroplasty.","authors":"Farzad Amouzadeh Omrani, Sina Afzal, Mojtaba Baroutkoub, Sohrab Salimi, Hasan Barati, Sina Azadnajafabad, Saeed Kokly, Mohammad Mehdi Omidian","doi":"10.4103/abr.abr_195_24","DOIUrl":"https://doi.org/10.4103/abr.abr_195_24","url":null,"abstract":"<p><strong>Background: </strong>Total hip arthroplasty (THA) stands as the definitive gold standard treatment for degenerative hip disorders. Various approaches have been proposed for THA, each with its own set of advantages and disadvantages. This study aimed to compare the initial functional outcomes of the lateral and posterolateral approaches to determine the approach with superior functional outcomes.</p><p><strong>Materials and methods: </strong>Through a retrospective cohort study, THA candidates over a 1-year period were analyzed. Patients who underwent surgery via the lateral or posterolateral approaches were included. Demographic characteristics of patients and postoperative outcomes were compared. Patients were followed up for 1 and 6 months to evaluate their functional outcomes using the Harris Hip Score (HHS).</p><p><strong>Results: </strong>A total of 50 THA candidates, divided into two groups of lateral (N = 25) and posterolateral (N = 25) approaches, were evaluated in this study. Comparison of demographic data revealed a significant difference in height and body mass index between the two groups (<i>P</i> < 0.05), whereas age and weight showed no significant difference (<i>P</i> > 0.05). The mean HHS and range of motion significantly improved in each group after 6 months (<i>P</i> < 0.001). No significant difference was observed between the lateral and posterolateral approaches in terms of HHS and hip range of motion (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>The results of this study demonstrate no significant difference between the outcomes of the lateral and posterolateral approaches for THA. The choice of the optimal THA approach remains contingent on the surgeon's experience and the patient's preference.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"13"},"PeriodicalIF":0.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of Quercetin in Mitigating Myocardial Ischemia-Reperfusion Injury: A Review Study.","authors":"Shirin Azizidoost, Maryam Adelipour, Habib Haybar, Zahra Shabaninejad, Mojtaba Rashidi","doi":"10.4103/abr.abr_166_24","DOIUrl":"https://doi.org/10.4103/abr.abr_166_24","url":null,"abstract":"<p><p>Myocardial ischemia-reperfusion injury (IRI) is introduced as a typical cardiovascular disorder with enhancing worldwide occurrence. It is generally persuaded via normal blood flow restoration to the ischemic myocardium after a recanalization period and instantly results in myocardial damage. Current investigations displays that flavonoids have the capability to function as cardioprotective agents versus IRI, which are faced in the myocardium. In this comprehensive review, we aim to delineate the therapeutic effects of quercetin in the context of myocardial IRI, shedding light on its potential as a cardioprotective agent. An up-to-date review of the literature on the cardioprotective impact of quercetin in myocardial IRI was conducted through Embase, all databases correlated to Science Direct, and Pubmed using the terms \"myocardial ischemia\", \"reperfusion injury\" and \"quercetin\". Quercetin exhibits protective effects against IRI through its anti-inflammatory, antioxidant, antiapoptotic, and calcium overload-reducing activities. The present review can emerge as a reference for planning a daily diet to prohibit or alleviate injuries following myocardial IRI and emerging flavonoids as a new window for clinical application.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"17"},"PeriodicalIF":0.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review on Important Risk Factors and Possible Involved Mechanisms of Medicinal Plants on Nonalcoholic Fatty Liver Disease.","authors":"Amir Reza Rouhi-Boroujeni, Fatemeh Aliakbari, Ehsan Bakhshian-Dehkordi, Lotfolah Afzali, Hojjat Rouhi-Boroujeni","doi":"10.4103/abr.abr_94_23","DOIUrl":"https://doi.org/10.4103/abr.abr_94_23","url":null,"abstract":"<p><p>Nonalcoholic fatty liver disease (NAFLD) is one of the most common diseases in the industrialized world. Hyperlipidemia, obesity, hypertension, and diabetes are known to be major risk factors for NAFLD, and chemical drugs are rarely effective in treating this disease and may cause significant complications. It is believed that medicinal plants with antioxidant properties and several other mechanisms have high preventive and therapeutic effects. This study was conducted with the aim of determining the effective mechanisms of plants on NAFLD and its risk factors. First, efficient plants and disease risk factors were identified; then, by reviewing scientific information sources and 6523 articles, the positive effects of plants on each risk factors were investigated. This information was recorded in checklist 1. Another 1100 articles (a total of 7623 articles) were systematically reviewed, and the mechanisms of the selected factories regarding the above risk factors were recorded in Checklist No. 2. Plants, their scientific names, family names, the used parts, and their possible mechanisms were identified in the case of 43 effective plants, and their molecular and genetic mechanisms were recorded. According to the results, 33 plants affect all four risk factors, eight of which affect three factors and two affect only two factors. In general, most of the mechanisms were in the prevention and treatment of NAFLD. Identification of plants and their effective mechanisms in NAFLD will reduce the incidence of this disease and produce new potent and selective herbal medicines that inhibit each of the risk factors.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"20"},"PeriodicalIF":0.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental Factors Associated to Functional Abdominal Pain Disorders in the Pediatric Age Group: A Case-Control Study.","authors":"Ensieh Taheri, Peiman Nasri, Fatemeh Famori, Majid Khademian, Hosein Saneian, Soroor Arman, Roya Kelishadi, Arefe Khaksar Jalali","doi":"10.4103/abr.abr_465_23","DOIUrl":"https://doi.org/10.4103/abr.abr_465_23","url":null,"abstract":"<p><strong>Background: </strong>Functional abdominal pain disorder (FAPD) is one of the most common reasons for medical visits in child and adolescents. While exact mechanisms remain incompletely understood, it is believed that psychosocial and parental factors contribute to the pathophysiology of FAPDs. Some research suggests a dyadic and reciprocal relationship between children and their parents in this context.</p><p><strong>Materials and methods: </strong>This is a case-control study that performed in pediatrics gastrointestinal clinics. All 4-16 years old children with abdominal pain, who were referred to pediatric clinics, were recruited consecutively. Individuals with abdominal pain complaint were classified as FAPD using Rome IV criteria. NEO Five-Factor Inventory was completed by all parents, both parents.</p><p><strong>Results: </strong>The mean and standard deviation age of the children in the case and control groups were 2.45 ± 8.10 and 3.04 ± 7.68, respectively, and there was no significant difference between the groups. However, the personality trait of neuroticism (<i>P</i> = 0.002) was significantly higher in the group of children with abdominal pain. The personality traits of extraversion and consciousness were more frequent in the control group than in the case group. Fathers' authoritarian behaviors and the frequency of mothers who showed more obsessive behaviors and had more control over their nutrition and weight were more common in the group of children who had abdominal pain.</p><p><strong>Conclusion: </strong>Parent's personality may be affected through different ways on FAPD in children. Diluting the adverse personality of parents alongside changing the relationship with their offspring is crucial to prevent or treatment of FAPD.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"14 ","pages":"9"},"PeriodicalIF":0.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}