Advanced biomedical research最新文献

{"title":"Design and Development of Mobile Application for Managing Poisoned Patients.","authors":"Shafeajafar Zoofaghari, Athar Omid, Asieh Maghami-Mehr, Farshad Lolasi","doi":"10.4103/abr.abr_430_23","DOIUrl":"10.4103/abr.abr_430_23","url":null,"abstract":"","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"107"},"PeriodicalIF":0.7,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indications of Amniocentesis and its Early and Late Complications.","authors":"Payman Rezagholi, Mohammad A Rasouli, Shamsi Zare","doi":"10.4103/abr.abr_408_23","DOIUrl":"10.4103/abr.abr_408_23","url":null,"abstract":"<p><strong>Background: </strong>Currently, it is recommended to arrange screening for all women who are referred for prenatal care before the 20^th week of gestation. Congenital and genetic diseases lead to disability and death in 3% of babies. Prenatal diagnosis is the only way to prevent the birth of babies with genetic disorders. This study was conducted with the aim of investigating the indications of amniocentesis as well as its early and late complications.</p><p><strong>Materials and methods: </strong>This retrospective study was conducted on 216 patients who were referred to the Perinatology Clinic of Sanandaj Besat Hospital in 2019-2020 and were candidates for amniocentesis. After collecting the data, analysis of data was done in SPSS software (version 21).</p><p><strong>Results: </strong>In the investigation of complications caused by amniocentesis, spontaneous abortion occurred in five cases (2.31%), amniotic fluid leakage in nine cases (4.6%), spotting in seven cases (3.24%), chorioamnionitis in one case (0.46%), and premature birth in 35 cases (16.2%). In this study, there were no reports of skin and eye complications.</p><p><strong>Conclusion: </strong>Based on the results of this research, the most common early and late complications were amniotic fluid leakage and childbirth before 37 weeks of gestation, respectively.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"103"},"PeriodicalIF":0.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Complications in Children Post COVID-19: A Systematic Review.","authors":"Alireza Ahmadi, Mohammad Reza Sabri, Mehdi Ghaderian, Bahar Dehghan, Chehreh Mahdavi, Niloofar Mohkamkar","doi":"10.4103/abr.abr_319_23","DOIUrl":"10.4103/abr.abr_319_23","url":null,"abstract":"<p><p>Cardiovascular involvements are one of the most important and threatening problems of SARS-CoV-2 infection and can cause a wide range of clinical manifestations in children. Therefore, a review of previous studies is necessary to prevent the occurrence of cardiovascular complications and reduce the risk of mortality in this age group of patients. To investigate the cardiovascular complications in children with COVID-19, international authoritative databases including PubMed, Scopus, Embase, Web of Science, Google Scholar, and Persian databases were searched using the main concepts, all articles were published between January 2020 and November 2022. According to the results of the present study, no deaths due to cardiovascular involvement were reported in the studied healthy children with COVID-19. In addition, in electrocardiogram (ECG) findings, supraventricular arrhythmias (SVA) and ventricular arrhythmias (VA) and in echo findings, left ventricular dysfunction (LVD) have had the most consequences.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"94"},"PeriodicalIF":0.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Antidepressant and Anxiolytic Effects of Escitalopram, Crocin, and their Combination in Rats.","authors":"Mehran Joodaki, Maryam Radahmadi, Hojjatallah Alaei","doi":"10.4103/abr.abr_259_23","DOIUrl":"10.4103/abr.abr_259_23","url":null,"abstract":"<p><strong>Background: </strong>Chronic stress can lead to anxiety and depression. Escitalopram is a selective serotonin reuptake inhibitor (SSRI), and crocin is a natural compound derived from saffron. Both of them are used to treat these disorders in clinical and traditional medicine, respectively. This study compared the antidepressant and anxiolytic effects of escitalopram, crocin, and their combination in rats.</p><p><strong>Materials and methods: </strong>Rats were divided into nine groups: control, sham, rest-depression, depression-rest, depression-crocin, depression-escitalopram10, depression-escitalopram20, depression-escitalopram10-crocin, and depression-escitalopram20-crocin. Forced swimming and open field tests (FST and OFT, respectively) were used to evaluate depression, anxiety, and locomotor activity.</p><p><strong>Results: </strong>In the FST, the immobility time on day 28 significantly decreased in all depressed groups that received escitalopram, crocin, and their combination compared to the rest-depression group. Whereas, conversely, the time spent at the center in the OFT was significantly higher in similar comparisons. The total distance traveled by the OFT was significantly lower in all depressed groups, except for the depression-escitalopram10 and depression-escitalopram20 groups. The total distance traveled was significantly higher in the depression-escitalopram20 compared to the rest-depression group.</p><p><strong>Conclusion: </strong>Crocin, both doses of escitalopram and their combination, reduced depression. A high dose of escitalopram, with and without crocin, was partially more effective than a low dose of escitalopram in reversing depression. There was anxiety-like behavior observed after inducing depression with and without a recovery period. Whereas, crocin alone and both doses of escitalopram, with and without crocin, decreased anxiety-like behaviors in subjects with depression. This effect may be attributed to a modulation of brain neurotransmitter ratios.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"99"},"PeriodicalIF":0.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-cemented Total Hip Arthroplasty in a Rare Case with Black Hip, A Case Report.","authors":"Ramin Shayan-Moghadam, Hasan Zolghadr, Erfan Babaei-Nejad, Hossein Shafiee","doi":"10.4103/abr.abr_199_23","DOIUrl":"10.4103/abr.abr_199_23","url":null,"abstract":"<p><p>Alkaptonuria is a metabolic disorder characterized by homogentisic acid accumulation in connective tissue. Ochronotic arthropathy, a rare condition reported in alkaptonuria, mostly affects the knee joint. In this study we reported a 57-year-old male patient presented with bilateral hip pain. During the operation, black bone tissue and tendons were observed. We examined the patient for alkaptonuria after the operation and the diagnosis was confirmed. In fact, alkaptonuria was not detected until the operation. Therefore, our study suggests that orthopedic surgeons be suspicious of atypical arthropathy in order to avoid being overwhelmed by the appearance of black cartilage during surgery.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"95"},"PeriodicalIF":0.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Extended-Release Bupropion and Duloxetine on Pelvic Pain and Sexual Function among Patients with Chronic Prostatitis/Chronic Pelvic Pain.","authors":"Shokufe Jaafari, Mitra Molaeinezhad, Mohammad J Tarrahi, Mohsen R Moosaei, Katayoun Sahfiei, Hamid Afshar","doi":"10.4103/abr.abr_202_23","DOIUrl":"10.4103/abr.abr_202_23","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare the efficacy of the two antidepressants, duloxetine and bupropion, on pelvic pain in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).</p><p><strong>Materials and methods: </strong>This single-blind clinical trial was conducted on 68 CP/CPPS patients. The patients with CP/CPPS received either an extended-release formulation of 150 mg/day bupropion (bupropion group) or duloxetine 30 mg/day for 12 weeks (duloxetine group). The pain, depression (using the Hospital Anxiety and Depression Scale (HADS)), quality of life (QoL), and sexual dysfunction scores were evaluated and compared before the intervention and after 4, 12, and 16 weeks of intervention in both groups.</p><p><strong>Results: </strong>The pain score in the duloxetine group was significantly lower than the bupropion group after 12 and 16 weeks of intervention (<i>P</i> value <0.05). The mean HADS and QoL scores at baseline and after 4, 12, and 16 weeks of intervention had insignificant differences between the two groups (<i>P</i> value >0.05) but improved in both groups. After 4 and 12 weeks of intervention, sexual dysfunction scores in the duloxetine group were higher than those in the bupropion group (<i>P</i> value <0.05).</p><p><strong>Conclusions: </strong>Depression and anxiety scores were significantly reduced in both groups. Sexual function was improved in the bupropion group compared with the duloxetine group, while pain scores improved significantly in the duloxetine group. Therefore, proposing the appropriate treatment based on the experienced complications of CP/CPPS is the key element of the management of these patients; however, further studies are required to compare the long-term effects of these two regimens on CP/CPPS patients' concerns.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"98"},"PeriodicalIF":0.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Functional Promoter Variants in Interleukin-18 on Susceptibility to Rheumatoid Arthritis in Iranian Population.","authors":"Mahboubeh Ramezanzadeh, Fatemeh Khodabandehloo, Samira Alesaeidi, Seyyed Hossein Mousavi, Shahryar Sadeghi, Naeim Ehtesham, Meysam Mosallaei, Ebrahim Hazrati","doi":"10.4103/abr.abr_29_24","DOIUrl":"10.4103/abr.abr_29_24","url":null,"abstract":"<p><strong>Background: </strong>Interleukin-18 (IL-18) is recognized for its pro-inflammatory properties and plays a central role in the progression of rheumatoid arthritis (RA). The specific single-nucleotide polymorphisms (SNPs), rs1946518 (-607C>A) and rs187238 (-137G<i>>C</i>), that are found in the IL-18 promoter region can potentially impact the expression of the IL-18 gene. This study aimed to investigate the correlation between these two polymorphisms and RA in the Iranian population.</p><p><strong>Materials and methods: </strong>In this study, we conducted a case-control analysis with a total of 275 subjects consisting of 135 patients with RA and 140 controls. The high-resolution melting (HRM) method, performed through real-time polymerase chain reaction, was utilized for genotyping these polymorphisms.</p><p><strong>Results: </strong>Regarding the rs1946518 polymorphism, the frequency of AA and CA genotypes and allele A was significantly greater in the control group compared to the RA group (AA vs CC; OR: 0.42; 95%CI [0.198-0.872], CA vs CC; OR: 0.57; 95%CI [0.324-1.001], A vs C; OR: 0.58; 95%CI [0.401-0.836] (<i>P</i> < 0.05). There was no statistically significant difference in the frequency of genotypes and allele frequencies between the control and patient groups in terms of the rs187238 polymorphism (<i>P</i> > 0.05). The level of both the C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) was notably elevated in the patient group with CC genotype in rs1946518 (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>In the rs1946518 polymorphism, the AA and AC genotypes and the A allele demonstrated protective effects in RA. Besides, the CC genotype was associated with some laboratory characteristics in the RA group.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"100"},"PeriodicalIF":0.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Resistance Pattern, Predisposing Factors, and Outcome of Serratia Infection in Patients Treated at a Secondary-Care Hospital in Oman: A 5-Year Retrospective Study.","authors":"Mohan B Sannathimmappa, Vinod Nambiar, Kaouthar Hilal Salim Hamood Al Siyabi, Aisha Shabbir Hussain, Yusra Abid Shah, Yamini Marimuthu, Salima Al-Maqbali, Madhavi Annamanedi, Elham Said Al-Risi, Rajeev Aravindakshan","doi":"10.4103/abr.abr_381_23","DOIUrl":"10.4103/abr.abr_381_23","url":null,"abstract":"<p><strong>Background: </strong><i>Serratia</i> has emerged as an important nosocomial opportunistic pathogen, often associated with serious infections. We investigated the antimicrobial resistance trends, predisposing factors, and infection outcomes associated with <i>Serratia species</i> isolated in a secondary-care hospital in Oman.</p><p><strong>Materials and methods: </strong>A retrospective study was conducted at a secondary-care hospital in the northern region of Oman after receiving approval from the research ethics and approval committee of Oman. The relevant data of patients diagnosed with <i>Serratia</i> infection during 2017-2021 was extracted from the Sohar Hospital health records. We statistically analyzed the data using the statistical software STATA version 14.</p><p><strong>Results: </strong>A total of 257 non-duplicate <i>Serratia strains</i> were studied. <i>S. marcescens</i> was the predominant (79.4%) isolated species. <i>Serratia</i> strains were more frequently isolated from males (51.4%). The most affected were older people aged > 60 years (29.4%), infants (28%), and patients treated at critical care units. <i>Serratia</i> has demonstrated high resistance to beta-lactams. The susceptibility rates of <i>Serratia</i> strains to tigecycline, ciprofloxacin, trimethoprim-sulfamethoxazole, gentamicin, amikacin, piperacillin-tazobactam, imipenem, and meropenem was high. Septicemia, pneumonia, mechanical ventilation, and hemodialysis were the independent risk factors for increased mortality among studied subjects (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>Our study results recommend empirical therapy with trimethoprim-sulfamethoxazole, piperacillin-tazobactam, aminoglycosides, and ciprofloxacin as first-line drugs for Serratia infection. The emergence of ESBL producers and carbapenem-resistant strains is worrisome. Regular updating of physicians' knowledge about antimicrobial profiles, antibiotic prescription policies, and infection control measures is necessary to combat antimicrobial resistance and improve outcomes.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"101"},"PeriodicalIF":0.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Vitamin D Supplementation on the Treatment of Pulmonary Tuberculosis Patients in Different Polymorphisms of the Vitamin D Receptor.","authors":"Hoda Bavi, Seyed Ahmad Hosseini, Alireza Ekrami, Seyed Mohammad Alavi, Amal Saki Malehi","doi":"10.4103/abr.abr_76_24","DOIUrl":"10.4103/abr.abr_76_24","url":null,"abstract":"<p><strong>Background: </strong>Vitamin D leads to the activation of macrophages and limitation of intracellular growth of Mycobacterium tuberculosis. Vitamin D receptor (VDR) gene polymorphisms can facilitate the development of tuberculosis (TB). Therefore, the present study aimed to investigate the effect of vitamin D supplementation on response to treatment in patients with pulmonary TB for different VDR polymorphisms.</p><p><strong>Materials and methods: </strong>This semiexperimental study was carried out over a 2-year period on 73 patients (37 females; 36 males) who suffered from pulmonary TB. Vitamin D supplement at a daily dose of 800 IU was administered to the patients for 8 weeks. The serum levels of vitamin D were measured by electrochemiluminescence immunoassay. The polymerase chain reaction with a sequence-specific primers technique was used to determine the polymorphisms FOK1, Bsm 1, Apa 1, and Taq1 of VDR gene.</p><p><strong>Results: </strong>The mean serum levels of vitamin D increased significantly after the intervention (44.88 ng/ml vs 27.70 ng/ml, <i>P</i> < 0.001). Those with FF genotype of Fok1 polymorphism had a higher chance of a positive response to treatment compared to the other genotypes (<i>P</i> = 0.044, 95% CI). Bsm1, Apa1, and Taq1 polymorphisms increased the treatment response, which was not statistically significant.</p><p><strong>Conclusion: </strong>The results of this study showed that individuals harboring FF genotype of Fok1 polymorphism had a higher chance of a positive response to treatment with vitamin D compared with other genotypes. Therefore, vitamin D supplement can be an appropriate treatment considering the genetic characteristics of TB patients.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"102"},"PeriodicalIF":0.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between Air Pollution and Serum Vitamin D Levels: A Systematic Review and Meta-Analysis.","authors":"Bahar Golastani, Parinaz Poursafa, Maryam Zarean, Maryam Yazdi, Motahar Heidari-Beni, Roya Kelishadi","doi":"10.4103/abr.abr_101_23","DOIUrl":"10.4103/abr.abr_101_23","url":null,"abstract":"<p><strong>Background: </strong>Elevated levels of atmospheric pollutants might disrupt the metabolism of vitamin D in the skin. Studies showed inconsistent results about the impact of air pollution on the serum vitamin D level. This study aims to systematically review the influence of air pollution on vitamin D levels.</p><p><strong>Materials and methods: </strong>The Medline database (PubMed), Web of Science, Scopus, and Google Scholar were systematically searched up to the end of July 2020. All observational, English-language, and human studies that assessed the effect of air pollution on vitamin D levels were included.</p><p><strong>Results: </strong>Among 432 studies, 26 papers were included in the systematic review and five studies in the meta-analysis. Exposure to air pollution was associated with lower vitamin D levels (pooled mean difference (MD) = -8.04, 95% confidence interval (CI): -10.34, -5.75). There was some evidence of heterogeneity between studies (I² = 91.39%).</p><p><strong>Conclusion: </strong>The findings revealed a reverse correlation between vitamin D levels and air pollution. Air pollutants have an impact on the penetration of solar ultraviolet B (UVB) to the Earth's surface. Consequently, the occurrence of vitamin D deficiency could be linked to air pollution.</p>","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"96"},"PeriodicalIF":0.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}