The in Vitro Antimicrobial Effect of Ethanolic Extracts of Aloe Vera on the H-pylori and Inhibitory Effect of Secondary Metabolites of Aloe Vera by Molecular Docking.

IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Advanced biomedical research Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI:10.4103/abr.abr_141_24

Roghayeh Farajnabi, Zahra Hojjati Bonab, Neda Shagayegh

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Abstract

Background: Helicobacter pylori is a Gram negative bacterium in the human stomach. Considering the side effects of the drug regimen and the prevalence of antibiotic resistance, in this project, the antimicrobial effect of aloe vera extracts on Helicobacter pylori was tested.

Materials and methods: Evaluation of the antimicrobial effect of aloe vera extract on Helicobacter pylori was done using diffusion methods in agar, and the diameter of the nongrowth halo was measured. The molecular interaction between the active ingredients of aloe vera and urease enzyme was investigated with Mulgroo Virtual Docker (MVD) software.

Results: The diameter of the halo of no growth at a concentration of 1000 mg/ml in aloe vera was 19 mm, and the maximum diameter of no growth was observed in the ethanolic extract.

Conclusion: According to our results, the ethanolic extract of aloe vera can be suggested as a good option as an antimicrobial supplement for Helicobacter pylori.

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通过分子对接研究芦荟醇提物对幽门螺杆菌的体外抑菌作用及对芦荟次生代谢产物的抑制作用。

背景：幽门螺杆菌是人类胃中的一种革兰氏阴性菌。考虑到药物方案的副作用和抗生素耐药性的普遍存在，本项目对芦荟提取物对幽门螺杆菌的抑菌效果进行了测试。材料与方法：采用琼脂扩散法评价芦荟提取物对幽门螺杆菌的抑菌效果，并测定非生长晕的直径。利用Mulgroo Virtual Docker （MVD）软件研究了芦荟活性成分与脲酶的分子相互作用。结果：在浓度为1000 mg/ml的芦荟中，无生长晕的直径为19 mm，乙醇提取物中无生长晕的最大直径为19 mm。结论：根据本研究结果，芦荟乙醇提取物可作为幽门螺杆菌的一种较好的抗菌补充剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced biomedical research

CiteScore

0.90

自引率

0.00%

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