Photodiagnosis and photodynamic therapy最新文献

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Efficacy of 50% vs. 100% Intensity Repeated Low-Level Red-Light on Choroidal Thickness and Vasculature: A Randomized Crossover Trial. 50%与100%重复低强度红光对脉络膜厚度和脉管系统的疗效:一项随机交叉试验。
IF 2.6
Photodiagnosis and photodynamic therapy Pub Date : 2025-10-05 DOI: 10.1016/j.pdpdt.2025.105240
Shiran Zhang, Yanxian Chen, Jian Zhang, Zhuoting Zhu, Xiaotong Han, Meng Xuan, Xiaohu Ding, Ruilin Xiong, Yixiong Yuan, Yueye Wang, Cong Li, Lirong Liao, Qiuxia Yin, Yingfeng Zheng, Xiangbin Kong, Mingguang He
{"title":"Efficacy of 50% vs. 100% Intensity Repeated Low-Level Red-Light on Choroidal Thickness and Vasculature: A Randomized Crossover Trial.","authors":"Shiran Zhang, Yanxian Chen, Jian Zhang, Zhuoting Zhu, Xiaotong Han, Meng Xuan, Xiaohu Ding, Ruilin Xiong, Yixiong Yuan, Yueye Wang, Cong Li, Lirong Liao, Qiuxia Yin, Yingfeng Zheng, Xiangbin Kong, Mingguang He","doi":"10.1016/j.pdpdt.2025.105240","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105240","url":null,"abstract":"<p><strong>Purpose: </strong>It is essential to determine if 50% repeated low-level red-light therapy (RLRL) can achieve the same choroidal thickening as the standard 100% intensity, potentially reducing energy use without sacrificing efficacy in myopia control. This study aimed to investigate the daily choroidal thickness (ChT) and vasculature, as surrogate outcomes for myopia control efficacy, with the RLRL at 100% and 50% intensity.</p><p><strong>Methods: </strong>This prospective crossover randomized controlled trial recruited adults aged 18-40 years with myopia. The study consisted of two 4-week treatment phases separated by a 4-week washout period, with participants randomly assigned to either a 100%-50% or 50%-100% RLRL treatment sequence. The primary outcomes were changes in subfoveal ChT (sfChT) and mean macular ChT (mChT) measured daily using swept-source optical coherence tomography. Secondary outcomes included macular choroidal vasculature.</p><p><strong>Results: </strong>The study included 27 participants (mean age, 21.2 years). After 1 month of treatment, both 50% and 100% RLRL resulted in significant increases in sfChT, mChT, and peripapillary ChT, with no significant differences between the groups. Choroidal thickening developed gradually over the treatment period, and daily change profiles in ChT and vasculature parameters were comparable.</p><p><strong>Conclusions: </strong>This study demonstrates that both 50% and 100% RLRL produced similar choroidal thickening, suggesting that 50% RLRL may offer comparable myopia control efficacy with reduced energy usage.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105240"},"PeriodicalIF":2.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating an immunotherapeutic approach to photodynamic therapy for glioblastoma. 评价光动力治疗胶质母细胞瘤的免疫治疗方法。
IF 2.6
Photodiagnosis and photodynamic therapy Pub Date : 2025-10-04 DOI: 10.1016/j.pdpdt.2025.105244
Yeo Song Kim, Byeong Geun Kang, Seung-Ho Yang, Sin-Soo Jeun, Soon A Park
{"title":"Evaluating an immunotherapeutic approach to photodynamic therapy for glioblastoma.","authors":"Yeo Song Kim, Byeong Geun Kang, Seung-Ho Yang, Sin-Soo Jeun, Soon A Park","doi":"10.1016/j.pdpdt.2025.105244","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105244","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, characterized by poor prognosis. Although immune checkpoint inhibitors (ICIs) such as anti-PD-L1 antibodies have demonstrated clinical success in various cancers, they do not elicit a response in GBM, as it is a cold tumor with low neoantigen load and T cell exhaustion. Photodynamic therapy (PDT) which uses light at an appropriate wavelength in combination with a photosensitizer to selectively destroy tumor cells, has recently gained attention for its potential to stimulate anti-tumor immune responses. Among available photosensitizers, 5-aminolevulinic acid (5-ALA) is clinically used in GBM surgery to visualize tumor margins and improve resection outcomes. Given its approved clinical use and surgical compatibility, 5-ALA-based PDT represents a promising strategy for integration into GBM treatment protocols. This study aimed to investigate whether 5-ALA-based PDT can enhance the efficacy of anti-PD-L1 therapy in GBM. In vitro, PD-L1 expression was evaluated in GL26 and U87 glioma cell lines as well as in patient-derived GBM cells. PD-L1 was expressed in some tumor cells while no PD-L1 expression was observed in others, indicating that the level of PD-L1 expression varies among glioblastomas. In the GL26 cell line, which initially exhibited low PD-L1 expression, treatment with 5-ALA PDT significantly increased PD-L1 expression. This suggests that the therapeutic efficacy of anti-PD-L1 treatment may be enhanced following 5-ALA PDT. In vivo, heterotopic (subcutaneous) and orthotopic GBM mouse models using the GL26 cells were established. Mice received 5-ALA PDT, anti-PD-L1, or a combination of both, and tumor growth, immune cell infiltration, and overall survival were evaluated. In the heterotopic (subcutaneous) model, GL26 cells was implanted into both flanks, with PDT applied to the left side, designated as the primary tumor. The right side, which did not receive PDT, was designated as the distant tumor. In this model, the combination of 5-ALA PDT and anti-PD-L1 treatment suppressed both primary and distant tumor growth, although the effect on distant tumors was not statistically significant. Additionally, in the combination group, infiltration of T cells, B cells, CD4⁺, CD8⁺ T cells increased in the primary tumors, and CD8⁺ T cells infiltration was elevated in primary and right-side distant tumors. In the orthotopic model, combination treatment significantly improved survival. Furthermore, enhanced T cells, CD8⁺ T cells and NKT cells responses were observed in brain tumor-infiltrating lymphocytes (TILs). Apoptosis was most pronounced in the combination group. These results suggest that 5-ALA PDT enhances the anti-tumor immune response and synergizes with anti-PD-L1 therapy in both heterotopic (subcutaneous) and orthotopic GBM models. Therefore, this combination strategy not only inhibits local and distant tumor growth but also prolongs survival, supporting it","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105244"},"PeriodicalIF":2.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photobiomodulation Enhances Osteogenesis in Oral and Adipose-Derived Mesenchymal Stem cells: A Systematic Review of In Vitro Evidence. 光生物调节促进口腔和脂肪来源的间充质干细胞成骨:体外证据的系统综述。
IF 2.6
Photodiagnosis and photodynamic therapy Pub Date : 2025-10-04 DOI: 10.1016/j.pdpdt.2025.105238
Neda Hakimiha, Negin Barzegar Reyhani, Arian Haddadi, Shabnam Aghayan
{"title":"Photobiomodulation Enhances Osteogenesis in Oral and Adipose-Derived Mesenchymal Stem cells: A Systematic Review of In Vitro Evidence.","authors":"Neda Hakimiha, Negin Barzegar Reyhani, Arian Haddadi, Shabnam Aghayan","doi":"10.1016/j.pdpdt.2025.105238","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105238","url":null,"abstract":"<p><strong>Objective: </strong>Photobiomodulation (PBM), a non-invasive light-based therapy, has gained attention for enhancing osteogenic differentiation in mesenchymal stem cells (MSCs). This systematic review evaluated in vitro evidence regarding PBM effects on the osteogenic differentiation of oral- and adipose-derived human MSCs and to identify effective irradiation parameters.</p><p><strong>Methods: </strong>A systematic search was conducted across PubMed, Scopus, Web of Science, and Google Scholar for studies published up to November 30, 2024. Of 1104 initially identified articles, 19 met eligibility criteria. They were assessed for methodological quality using the QUIN tool, and Data on cell source, laser parameters, and osteogenic outcomes were extracted.</p><p><strong>Results: </strong>PBM enhanced proliferation and osteogenic differentiation in MSCs, particularly periodontal ligament stem cells (PDLSCs), dental pulp stem cells (DPSCs), and adipose-derived stem cells (ADSCs). Effective wavelengths, associated with statistically significant osteogenic outcomes, ranged from 660 to 1064 nm, with energy densities of approximately 2-6 J/cm² showing the most consistent osteogenic responses. Key markers such as ALP, RUNX2, and OCN were upregulated, with enhanced mineralization observed. Mechanistically, PBM activated Wnt/β-catenin, BMP/Smad, and PI3K/Akt signalling pathways. QUIN risk-of-bias assessment indicated low risk in most studies, although some showed medium risk due to incomplete reporting.</p><p><strong>Conclusion: </strong>PBM appears to be a promising adjunctive strategy to promote osteogenic differentiation in vitro using oral- and adipose-derived MSCs. Nevertheless, methodological heterogeneity in study designs and outcome measures highlights the need for standardized protocols. Further translational and clinical studies are warranted to optimize PBM parameters and validate its therapeutic utility in regenerative dentistry and maxillofacial applications.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105238"},"PeriodicalIF":2.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphologic and Functional Assessment of Photoreceptors in Anisometropic Amblyopia Using Adaptive Optics Scanning Laser Ophthalmoscopy. 自适应光学扫描激光验光对参差性弱视光感受器的形态学和功能评价。
IF 2.6
Photodiagnosis and photodynamic therapy Pub Date : 2025-10-03 DOI: 10.1016/j.pdpdt.2025.105241
Hang Yang, Maoxia Lv, Jie Peng, Qian Luo, Zhengzheng Wu, Yan Tong, Yanxi Xie, Jing Li, Yin Yang, Lin Zhou
{"title":"Morphologic and Functional Assessment of Photoreceptors in Anisometropic Amblyopia Using Adaptive Optics Scanning Laser Ophthalmoscopy.","authors":"Hang Yang, Maoxia Lv, Jie Peng, Qian Luo, Zhengzheng Wu, Yan Tong, Yanxi Xie, Jing Li, Yin Yang, Lin Zhou","doi":"10.1016/j.pdpdt.2025.105241","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105241","url":null,"abstract":"<p><strong>Objective: </strong>Using adaptive optics scanning laser ophthalmoscopy (AO-SLO) to investigate the cone photoreceptor structure in children with anisometropic amblyopia and to examine its correlation with contrast sensitivity function (CSF).</p><p><strong>Methods: </strong>Fifteen patients with monocular anisometropic amblyopia (amblyopic eyes, AE; fellow eyes, FE) and 15 age-matched controls (normal eyes, NE) were enrolled (45 eyes). Data on macular cone photoreceptor density, spacing, and regularity; retinal and choroidal thickness; superficial capillary plexus vessel density (SCP-VD); choroidal vascularity index (CVI); and contrast sensitivity function (CSF) were collected. Statistical analyses were performed using one-way analysis of variance (ANOVA), Pearson correlation, and multivariate linear regression.</p><p><strong>Results: </strong>Compared to the FE and NE groups, the AE group showed significantly reduced cone density (28,519.12 ± 2,853.41 vs. 35,529.21 ± 2,217.35 and 36,181.62 ± 3,081.95 cells/mm², P < 0.01), increased spacing (6.36 ± 1.64 vs. 4.22 ± 0.41 vs. 4.13 ± 0.50 μm, P < 0.01), and decreased regularity (92.99 ± 1.49% vs. 95.86 ± 1.20% vs. 95.90 ± 1.03%; P < 0.01). The Area Under the Log Contrast Sensitivity Function (AULCSF) of the AE group (1.61 ± 0.08) was significantly lower than that of the FE (1.84 ± 0.04) and NE groups (1.87 ± 0.08; P < 0.01). CSF was positively correlated with cone density (R² = 0.899, P < 0.001) and regularity (R² = 0.530, P = 0.002) and negatively correlated with cone spacing (R² = 0.539, P = 0.002). Multivariate regression analysis revealed that cone density (β = 0.701, P < 0.001) and cone regularity (β = 0.228, P = 0.026) had a positive predictive effect on AULCSF.</p><p><strong>Conclusion: </strong>Anisometropic amblyopia shows disrupted macular cone structure, including reduced density and irregular spacing, which closely relates to impaired contrast sensitivity. AO-SLO can help assess these retinal deficits in developmental visual disorders.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105241"},"PeriodicalIF":2.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compare of the scleral morphology between healthy populations and keratoconus patients using optical coherence tomography. 光学相干断层扫描对健康人群与圆锥角膜患者巩膜形态的比较。
IF 2.6
Photodiagnosis and photodynamic therapy Pub Date : 2025-10-03 DOI: 10.1016/j.pdpdt.2025.105243
Chao Wan, Longwang Wu, Zhixiang Yan, Bo Liu, Tao Yu, Ke Wang, Xiangyu He, Yuli Yang
{"title":"Compare of the scleral morphology between healthy populations and keratoconus patients using optical coherence tomography.","authors":"Chao Wan, Longwang Wu, Zhixiang Yan, Bo Liu, Tao Yu, Ke Wang, Xiangyu He, Yuli Yang","doi":"10.1016/j.pdpdt.2025.105243","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105243","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To scan and measure the scleral morphology of healthy eyes and keratoconus eyes using Optical Coherence Tomography (OCT), evaluate the differences in scleral morphology between them, and provide a more scientific basis for the precise fitting of scleral lenses.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 85 subjects who were admitted to the First Affiliated Hospital of Army Medical University from March 2024 to November 2024 and underwent OCT examination were selected as the research subjects. They were divided into a healthy group (64 cases, 120 eyes) and a keratoconus group (21 cases, 40 eyes) according to whether they had the disease. Each subject underwent anterior segment OCT examination to measure and obtain corneoscleral parameters such as the Corneoscleral Junction Angle (CSJA), Scleral Angle (SA), Sagittal Height (SH), and Scleral Toricity (ST). The differences in the above parameters at different chord lengths and in different orientations were compared, and these parameters of the two groups of subjects were also compared.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In both groups, the CSJA was the largest in the superior position and the smallest in the nasal position, and the difference was statistically significant (P&lt;0.05). The average nasal CSJA in the keratoconus group was 175.6°, while that in the healthy group was 177.0°, and the difference was statistically significant (P&lt;0.05). In the healthy group, at a chord length of 10.0 mm, the SA was the largest in the superonasal position and the smallest in the temporal position; at chord lengths of 12.8 mm, 14.0 mm, and 15.0 mm, the SA was the largest in the temporal position and the smallest in the superonasal position, and the difference was statistically significant (P&lt;0.05). In the keratoconus group, at a chord length of 10.0 mm, the SA was the largest in the superonasal position and the smallest in the temporal position; at a chord length of 12.8 mm, the SA was the largest in the temporal position and the smallest in the superonasal position; at chord lengths of 14.0 mm and 15.0 mm, the SA was the largest in the inferotemporal position and the smallest in the nasal position, and the difference was statistically significant (P&lt;0.05). At chord lengths of 10.0 mm, 12.8 mm, 14.0 mm, and 15.0 mm, the SH in the keratoconus group was greater than that in the healthy group, and the difference was statistically significant (P&lt;0.05). The ST of both groups increased with the increase of the chord length. In the healthy group, the ST increased from 0.06 mm at chord length of 10.0 mm to 0.16 mm at chord length of 15.0 mm. In the keratoconus group, the ST increased from 0.11 mm at chord length of 10.0 mm to 0.20 mm at chord length of 15.0 mm, and the difference was statistically significant (P&lt;0.05); at chord lengths of 10.0 mm, 12.8 mm, 14.0 mm, and 15.0 mm, the ST in the keratoconus group was greater than that in the healthy group, and the difference was statistically sign","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105243"},"PeriodicalIF":2.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect Effectiveness of Photobiomodulation Therapy in the Management of Myofascial Pain Dysfunction Syndrome: A Randomized Triple-Blind Clinical Trial. 光生物调节治疗肌筋膜疼痛功能障碍综合征的疗效:一项随机三盲临床试验。
IF 2.6
Photodiagnosis and photodynamic therapy Pub Date : 2025-10-01 DOI: 10.1016/j.pdpdt.2025.105239
Behzad Salari, Amin Khalghy, Sahar Mafi, Reza Fekrazad
{"title":"Effect Effectiveness of Photobiomodulation Therapy in the Management of Myofascial Pain Dysfunction Syndrome: A Randomized Triple-Blind Clinical Trial.","authors":"Behzad Salari, Amin Khalghy, Sahar Mafi, Reza Fekrazad","doi":"10.1016/j.pdpdt.2025.105239","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105239","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the effectiveness of photobiomodulation therapy (PBMT) by two wavelengths in reducing pain and enhancing jaw function in patients with myofascial pain dysfunction syndrome (MPDS).</p><p><strong>Methods: </strong>A triple-blind, randomized controlled trial was conducted in 22 patients with MPDS, who were randomly assigned to two groups (n=11). One group received photobiomodulation therapy using wavelengths of 630 and 810 nm (energy densities: 4-6 J/cm², power: 200 mW, irradiation time: 60 seconds per point), while the control group underwent sham laser treatment (device turned off), in addition to standard conservative care. The laser was administered daily for the first three days, followed by alternate-day sessions for one week, totaling 12 sessions. Pain intensity was measured using a visual analog scale (VAS), and maximum mouth opening (MMO) was recorded before treatment and at 1-, 2-, 3-, and 4-weeks post-treatment. Data were analyzed using independent and paired t-tests, and repeated measures ANOVA.</p><p><strong>Results: </strong>Both PBMT and control groups experienced significant pain reduction over time (P=0.0001). The rate of pain reduction was similar in both groups (P=0.89). Both groups showed significant MMO improvement (P=0.015), but the trend in improvement was not significantly different between them (P=0.86).</p><p><strong>Conclusion: </strong>Photobiomodulation therapy, under the tested parameters, effectively reduced pain and improved jaw function in patients with MPDS, comparable to conventional conservative care.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105239"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The corneal biomechanics of the posterior staphyloma. 后葡萄肿的角膜生物力学。
IF 2.6
Photodiagnosis and photodynamic therapy Pub Date : 2025-09-23 DOI: 10.1016/j.pdpdt.2025.105231
Xiqiong Liao, Guanshun Yu, Yi Jiang, Xiaoyu Zhuang, Shumeng Yao, Kaige Li, Shuhan Yu, Yi Wang, Qi Dai, Lin Fu
{"title":"The corneal biomechanics of the posterior staphyloma.","authors":"Xiqiong Liao, Guanshun Yu, Yi Jiang, Xiaoyu Zhuang, Shumeng Yao, Kaige Li, Shuhan Yu, Yi Wang, Qi Dai, Lin Fu","doi":"10.1016/j.pdpdt.2025.105231","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105231","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the corneal biomechanical differences of eyes with and without posterior staphyloma (PS) using Corneal Visualization Scheimpflug Technology (Corvis ST).</p><p><strong>Methods: </strong>This is a cross-sectional study. The patients were classified into the PS group and control group. Corneal biomechanical parameters were measured by Corvis ST and compared between the two groups and among different PS subtypes.</p><p><strong>Results: </strong>This study included 40 patients in the PS group and the control group respectively. The deformation amplitude at the highest concavity (HCDA), deflection amplitude at the highest concavity, max deflection amplitude (DLA max) and deformation amplitude ratio max at 2mm were significant higher in the PS group after adjusting the axial length (AL). After matching the AL, only the HCDA and DLA max were significantly greater in the PS group. There was no significant difference in corneal biomechanical parameters among the subtype PS. The A2 V, PD, Radius, HCDA, HCDLL, HCDLA, A2DLA, DLAmax, HC dArc Length, A2 dArc Length, dArc Length Max, DA Ratio Max, Integrated Radius are significantly correlated with PS. In distinguishing PS, DLA Max achieved the highest diagnostic performance, with an area under the receiver operating characteristic curve (AUROC) of 0.79 (95% CI,0.71-0.85), meanwhile, the area under the ROC curve of all data after the combination of gender and age was 0.813(95%CI:0.74-0.88).</p><p><strong>Conclusion: </strong>Eyes with posterior staphyloma (PS) exhibit greater corneal deformability, elasticity, and viscoelasticity than controls, independent of PS location. These findings suggest PS impacts the anterior ocular wall, offering insights into PS pathogenesis.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105231"},"PeriodicalIF":2.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Analysis of Anterior and Posterior Segment Parameters in the Fellow Eye of Unilateral Pseudoexfoliation Glaucoma. 单侧假脱落性青光眼同侧眼前后段参数的比较分析。
IF 2.6
Photodiagnosis and photodynamic therapy Pub Date : 2025-09-18 DOI: 10.1016/j.pdpdt.2025.105224
Zeynep Duru, Mutluay Bozoklu
{"title":"Comparative Analysis of Anterior and Posterior Segment Parameters in the Fellow Eye of Unilateral Pseudoexfoliation Glaucoma.","authors":"Zeynep Duru, Mutluay Bozoklu","doi":"10.1016/j.pdpdt.2025.105224","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105224","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate structural and microvascular changes in affected and clinically unaffected fellow eyes of patients with unilateral pseudoexfoliation glaucoma (PEG), and compared with healthy controls.</p><p><strong>Methods: </strong>In this prospective, cross-sectional study, 30 patients with unilateral PEG and 27 age-matched controls underwent ocular biometry, corneal tomography, specular microscopy, swept-source optical coherence tomography (SS-OCT), and OCT angiography (OCT-A). Central corneal thickness, anterior chamber depth and angle, lens thickness, pupil diameter, chord mu, axial length, and endothelial cell density, peripapillary retinal nerve fiber layer (RNFL), macular ganglion cell layer-inner plexiform layer (GCL-IPL), lamina cribrosa thickness (LCT) and depth (LCD), Bruch's membrane opening distance (BMO-D), subfoveal choroidal thickness (SFCT), and macular superficial capillary plexus vessel density (SCP VD) were evaluated.</p><p><strong>Results: </strong>Anterior segment parameters were largely similar across PEG, fellow, and control eyes, except for a slightly shallower anterior chamber in PEG eyes (p=0.032). PEG eyes showed significantly reduced RNFL and GCL-IPL thickness compared with fellow and control eyes, while fellow eyes were comparable to controls. LCT was thinner in PEG eyes, whereas LCD, BMO-D, and SFCT showed no differences. OCT-A revealed reduced SCP VD in inferior, nasal, and temporal quadrants of PEG eyes, with preserved foveal perfusion. Fellow eyes did not demonstrate significant vascular changes.</p><p><strong>Conclusion: </strong>PEG eyes exhibit pronounced structural and microvascular compromise, while anterior segment parameters remain mostly preserved. Clinically unaffected fellow eyes are similar to healthy controls, highlighting the asymmetric clinical manifestation of pseudoexfoliation. SS-OCT and OCT-A offer valuable insight into early glaucomatous damage in PEG.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105224"},"PeriodicalIF":2.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distribution and Determinants of Lens Biometrics in Cataract Patients: Insights from Biometrics and Implications for Surgical Precision. 白内障患者晶状体生物特征的分布和决定因素:来自生物特征的见解和对手术精度的影响。
IF 2.6
Photodiagnosis and photodynamic therapy Pub Date : 2025-09-12 DOI: 10.1016/j.pdpdt.2025.105221
Chunwen Zheng, Ruirui Ma, Xiaoning Hao, Wenwen Geng, Ling Jin, Yijun Hu
{"title":"Distribution and Determinants of Lens Biometrics in Cataract Patients: Insights from Biometrics and Implications for Surgical Precision.","authors":"Chunwen Zheng, Ruirui Ma, Xiaoning Hao, Wenwen Geng, Ling Jin, Yijun Hu","doi":"10.1016/j.pdpdt.2025.105221","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105221","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;To investigate the distribution patterns of lens-specific biometrics, including lens thickness (LT), relative lens thickness (RLT), lens position (LP), and relative lens position (RLP), and their determinants among the other ocular biometrics in patients with cataract.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;A retrospective and cross-sectional study was performed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting: &lt;/strong&gt;This study was conducted in a tertiary care ophthalmology department in Shenzhen, China, between 2022 and 2024.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Participants: &lt;/strong&gt;A total of 715 cataract patients with bilateral ocular biometric measurements using Lenstar LS-900 were recruited.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcome measures: &lt;/strong&gt;The lens-specific biometrics of the bilateral eyes were analyzed separately, with results of the left eyes to validate those of the right eyes. The eyes were divided into two sex groups, three axial length (AL) groups, and four age groups. Independent t-test and Mann-Whitney U test were performed to analyze the differences in sex groups. One-way analysis of variance and Kruskal-Wallis test were used to compare different age and axial length groups. Spearman's correlation tests were conducted to assess the correlations between each lens-specific biometric and the other ocular biometrics, including central corneal thickness (CCT), corneal curvature (CR), anterior chamber depth (ACD), AL, white-to-white corneal diameter (WTW), anterior corneal astigmatism (ACA), pupil size (PS), angle kappa, and iris center distance (ICD). Univariable and multivariable linear regression analyses were used to determine those independent determinants for lens-specific biometrics.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;LT was significantly thicker in females, older patients, and eyes of shorter AL (all P &lt; 0.05, except in the sex group of the left eyes), while RLT was increased in eyes of short AL and older patients in bilateral eyes. LP showed anterior displacement in females, older patients, and eyes of shorter AL in both right and left eyes, while RLP only showed significant differences in different AL groups (P &lt; 0.0001). ACD was correlated to all lens-specific biometrics in bilateral eyes (r = -0.77 to 0.87), while correlations of other ocular biometrics to lens-specific biometrics varied between right and left eyes. ACD was identified as the dominant determinant for all lens-specific biometrics in bilateral eyes (β = -0.70 to 0.66). AL was found to inversely predict the RLT and RLP changes in both eyes (all β = -0.01).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Distributions of lens-specific biometrics varied with sex, age, and AL, and the lens-specific biometrics were correlated to similar but also distinct determinants in bilateral eyes. Our study provides a better understanding of the significance of lensspecific biometrics in preoperative assessments and personalization of cataract surgery in patients with diverse anatomical and demographic characteristics.&lt;/p","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105221"},"PeriodicalIF":2.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Er Cr: YSGG laser, ytterbium fiber laser, and Rose Bengal-activated low-level laser therapy on roughness and shear bond strength of yttria-stabilized zirconia. Er Cr: YSGG激光、镱光纤激光和玫瑰红激活低能级激光治疗氧化钇稳定氧化锆的粗糙度和剪切结合强度。
IF 2.6
Photodiagnosis and photodynamic therapy Pub Date : 2025-08-27 DOI: 10.1016/j.pdpdt.2025.104784
Ghadeer Islem Basunbul
{"title":"Er Cr: YSGG laser, ytterbium fiber laser, and Rose Bengal-activated low-level laser therapy on roughness and shear bond strength of yttria-stabilized zirconia.","authors":"Ghadeer Islem Basunbul","doi":"10.1016/j.pdpdt.2025.104784","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104784","url":null,"abstract":"<p><strong>Aim: </strong>Effect of Er Cr: YSGG laser (ECL), ytterbium fiber laser (YFL), Rose Bengal (RB) activated low-level laser therapy (LLLT) on the surface roughness (Ra) and shear bond strength (SBS) of yttrium-stabilized tetragonal zirconia polycrystal (Y-TZP) bonded to resin cement.</p><p><strong>Materials and methods: </strong>Sixty-four 3Y-TZP discs were prepared, and subsequently, categorized into four distinct groups based on the conditioning regimen (n=16): Group 1 (SB), Group 2 (ECL), Group 3 (YFL), and Group 4 (LLLT-RB). The Ra assessment was performed on five samples from each group using a profilometer. One specimen from each group was subjected to surface topography analysis under a scanning electron microscope (SEM). A self-adhesive resin cement was built on ten samples from each group and photo polymerized, followed by artificial ageing. The SBS and failure modes were assessed using a universal testing machine and a stereomicroscope, respectively. The data was evaluated using ANOVA and a post hoc test, p = 0.05.</p><p><strong>Results: </strong>Samples surface treated with YFL attained the highest Ra scores (1334.32 ± 0.065 µm) and highest bond strength (9.34±0.29 MPa). In contrast, the 3Y-TZP discs surface treated with LLLT-RB exhibited the lowest Ra value (870.56 ± 0.076 µm) and the lowest bond values (5.76±0.34 MPa). Zirconia disc surface treated with ECL and SB groups demonstrated admixed failures. LLLT (RB), on the other hand, exhibited adhesive fractures with the highest frequency.</p><p><strong>Conclusion: </strong>Ytterbium fiber laser displayed the most satisfactory performance in terms of improving surface roughness and shear bond strength of zirconia with the resin cement, and can be used as an alternative surface pretreating regime for zirconia.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104784"},"PeriodicalIF":2.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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