Photodiagnosis and photodynamic therapy最新文献

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Photobiomodulation therapy facilitates transplantation of dental pulp stem cells for spinal cord injury.
Photodiagnosis and photodynamic therapy Pub Date : 2025-03-14 DOI: 10.1016/j.pdpdt.2025.104559
Xinran Zhang, Wenwen Yang, Biao Zhu, Lin Su, Haotian Li
{"title":"Photobiomodulation therapy facilitates transplantation of dental pulp stem cells for spinal cord injury.","authors":"Xinran Zhang, Wenwen Yang, Biao Zhu, Lin Su, Haotian Li","doi":"10.1016/j.pdpdt.2025.104559","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104559","url":null,"abstract":"<p><strong>Background: </strong>While dental pulp stem cells (DPSCs) show therapeutic potential for spinal cord injury (SCI), post-traumatic oxidative stress and mitochondrial dysfunction critically compromise grafted cell survival. Photobiomodulation therapy (PBMT) is a noninvasive approach that may enhance regenerative efficacy. This study investigates whether PBMT improves the survival and neural differentiation of transplanted DPSCs in SCI models.</p><p><strong>Methods: </strong>In vitro, the anti-apoptotic effects of PBMT were investigated in H<sub>2</sub>O<sub>2</sub>-induced DPSCs injury model via TUNEL staining, flow cytometry, biochemical assays and transmission electron microscopy. In vivo, spinal cord restoration was evaluated using behavioral tests and histological staining, and the survival status and neural differentiation of grafted DPSCs were respectively tracked through bioluminescence imaging and immunofluorescent staining in DPSCs co-expressing luciferin and green fluorescent protein (Luc-GFP-DPSCs) transplanted SCI mice with/without PBMT.</p><p><strong>Results: </strong>PBMT demonstrated protective effects by relieving apoptosis and oxidative stress in engrafted DPSCs in vitro. Furthermore, PBMT-assisted DPSCs transplantation significantly promoted cell survival and neural differentiation, achieving superior functional recovery compared to transplantation alone.</p><p><strong>Conclusions: </strong>PBMT facilitates DPSCs transplantation in SCI through mitigation of oxidative apoptosis and enhancement of grafted cell survival and differentiation.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104559"},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The clinical value of reflectance confocal microscopy in monitoring treatment of actinic keratosis: A systematic review.
Photodiagnosis and photodynamic therapy Pub Date : 2025-03-01 DOI: 10.1016/j.pdpdt.2025.104539
Jinrui Zhang, Haolong Ran, Yongyao Zhao, Xiyu Liang, Zhiqian Gu, Yanning Xue
{"title":"The clinical value of reflectance confocal microscopy in monitoring treatment of actinic keratosis: A systematic review.","authors":"Jinrui Zhang, Haolong Ran, Yongyao Zhao, Xiyu Liang, Zhiqian Gu, Yanning Xue","doi":"10.1016/j.pdpdt.2025.104539","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104539","url":null,"abstract":"<p><strong>Background: </strong>Actinic keratosis (AK) is a precancerous skin lesion that can progress to squamous cell carcinoma (SCC). Early diagnosis and effective treatment are crucial, but current treatment evaluation methods lack consistency. Reflectance confocal microscopy (RCM) has emerged as a promising non-invasive tool for monitoring treatment outcomes in AK, but the absence of standardized evaluation protocols limits its clinical applicability.</p><p><strong>Objective: </strong>This study aims to establish standardized RCM imaging features for evaluating treatment responses in AK, thereby enhancing the consistency and clinical utility of RCM in treatment monitoring.</p><p><strong>Methods: </strong>A systematic review was conducted following the PRISMA 2020 guidelines. Studies that evaluated the treatment of AK using RCM were included. A comprehensive literature search was performed across MEDLINE, Embase, and the Cochrane Library up to October 2024. Data on study design, treatment modalities, RCM imaging features, and scoring systems were extracted. A meta-analysis was not performed due to heterogeneity in study designs and outcome measures.</p><p><strong>Conclusion: </strong>This review identifies key RCM imaging features of AK, including keratinocyte atypia and architectural disarray, and highlights the lack of a standardized scoring system for evaluating treatment outcomes. The findings underscore the need for a universally accepted protocol to improve the consistency and reliability of RCM in clinical practice. Standardization of RCM evaluation will enhance its utility in both clinical monitoring and future research on AK treatment.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104539"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fundus Changes in Healthy Adults After High Altitude Exposure.
Photodiagnosis and photodynamic therapy Pub Date : 2025-03-01 DOI: 10.1016/j.pdpdt.2025.104542
Jiaxin Li, Yunzhu Kong, Peiyu Wang, Chen Chen, Yan Shao, Juping Liu, Xiaorong Li
{"title":"Fundus Changes in Healthy Adults After High Altitude Exposure.","authors":"Jiaxin Li, Yunzhu Kong, Peiyu Wang, Chen Chen, Yan Shao, Juping Liu, Xiaorong Li","doi":"10.1016/j.pdpdt.2025.104542","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104542","url":null,"abstract":"<p><strong>Background: </strong>To quantify the changes of long-term high altitude (HA) exposure of fundus in healthy adults. The aim is to provide a reference for the prevention and treatment of high altitude ophthalmopathy.</p><p><strong>Methods: </strong>30 eyes of 15 healthy participants exposed to high altitude were recruited in this study. Swept-source optical coherence tomography/Swept-source optical coherence tomography angiography (SS-OCT/SS-OCTA) was used to analyze fundus changes in participants before and after plateau exposure. Fundus metrics included best corrected visual acuity (BCVA), the thickness of the retina (ReT), Inner ReT, Outer ReT, nerve fiber layer thickness (RNFLT), and ganglion cell internal plexiform layer thickness (GCIPLT), vascular density (VD), the size of the perfusion area (PA), choroidal vessel volume (CVV), and choroidal vascularity index (CVI) in all quadrants of the macula. All metrics were analyzed by generalized estimating equations (GEE).</p><p><strong>Results: </strong>Compared with baseline data, all participants who worked at high altitude for more than one year showed no change in visual acuity (P>0.05) and a decreased in ReT, Outer ReT, GCIPLT and VD in all quadrants (P>0.05). In addition, Inner ReT and RNFLT show an upward trend (P>0.05). PA was significantly increased in the overall retina, Inner retina, superficial capillary plexus (SCP), and middle capillary plexus (ICP) (P<0.05).</p><p><strong>Conclusion: </strong>The systemic adaptive changes due to high altitude exposure may cause varying degrees of structural and functional changes in the fundus. The current findings require large-scale longitudinal studies to obtain more definitive data on this topic.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104542"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Antimicrobial Photodynamic Inactivation of Pseudomonas aeruginosa Persister Cells and Biofilms" [Photodiagnosis and Photodynamic Therapy 51 (2025) 104456].
Photodiagnosis and photodynamic therapy Pub Date : 2025-02-17 DOI: 10.1016/j.pdpdt.2025.104508
Mona Mahmoud, Peter Richter, Philipp Arnold, Michael Lebert, Andreas Burkovski
{"title":"Corrigendum to \"Antimicrobial Photodynamic Inactivation of Pseudomonas aeruginosa Persister Cells and Biofilms\" [Photodiagnosis and Photodynamic Therapy 51 (2025) 104456].","authors":"Mona Mahmoud, Peter Richter, Philipp Arnold, Michael Lebert, Andreas Burkovski","doi":"10.1016/j.pdpdt.2025.104508","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104508","url":null,"abstract":"","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104508"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Inhibition of efflux pump encoding genes and biofilm formation by sub-lethal photodynamic therapy in methicillin susceptible and resistant Staphylococcus aureus" [Photodiagnosis and Photodynamic Therapy 102900 (2022) 102900].
Photodiagnosis and photodynamic therapy Pub Date : 2025-02-04 DOI: 10.1016/j.pdpdt.2025.104492
Yanlan Yu, Yan Zhao, Yaxiong He, Jiayin Pang, Zengjun Yang, Mengxue Zheng, Rui Yin
{"title":"Corrigendum to \"Inhibition of efflux pump encoding genes and biofilm formation by sub-lethal photodynamic therapy in methicillin susceptible and resistant Staphylococcus aureus\" [Photodiagnosis and Photodynamic Therapy 102900 (2022) 102900].","authors":"Yanlan Yu, Yan Zhao, Yaxiong He, Jiayin Pang, Zengjun Yang, Mengxue Zheng, Rui Yin","doi":"10.1016/j.pdpdt.2025.104492","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104492","url":null,"abstract":"","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104492"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Annals of photodynamic therapy: Publish and/or perish? 光动力疗法年鉴》:发表和/或毁灭。
Photodiagnosis and photodynamic therapy Pub Date : 2024-11-09 DOI: 10.1016/j.pdpdt.2024.104398
David Kessel
{"title":"Annals of photodynamic therapy: Publish and/or perish?","authors":"David Kessel","doi":"10.1016/j.pdpdt.2024.104398","DOIUrl":"10.1016/j.pdpdt.2024.104398","url":null,"abstract":"","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104398"},"PeriodicalIF":0.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction to 18th International Photodynamic Association World Congress. 第 18 届国际光动力协会世界大会简介。
Photodiagnosis and photodynamic therapy Pub Date : 2024-04-01 DOI: 10.1016/j.pdpdt.2024.104079
Dr. Lothar Lilge
{"title":"Introduction to 18th International Photodynamic Association World Congress.","authors":"Dr. Lothar Lilge","doi":"10.1016/j.pdpdt.2024.104079","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2024.104079","url":null,"abstract":"","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":"88 3","pages":"104079"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140779344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigations on correlations between changes of optical tissue properties and NMR relaxation times. 关于光学组织特性变化与核磁共振弛豫时间之间相关性的研究。
Photodiagnosis and photodynamic therapy Pub Date : 2024-02-01 Epub Date: 2024-01-10 DOI: 10.1016/j.pdpdt.2024.103968
Maximilian Aumiller, Asmerom Arazar, Ronald Sroka, Olaf Dietrich, Adrian Rühm
{"title":"Investigations on correlations between changes of optical tissue properties and NMR relaxation times.","authors":"Maximilian Aumiller, Asmerom Arazar, Ronald Sroka, Olaf Dietrich, Adrian Rühm","doi":"10.1016/j.pdpdt.2024.103968","DOIUrl":"10.1016/j.pdpdt.2024.103968","url":null,"abstract":"<p><strong>Background: </strong>Accurate light dosimetry is a complex remaining challenge in interstitial photodynamic therapy (iPDT) for malignant gliomas. The light dosimetry should ideally be based on the tissue morphology and the individual optical tissue properties of each tissue type in the target region. First investigations are reported on using NMR information to estimate changes of individual optical tissue properties.</p><p><strong>Methods: </strong>Porcine brain tissue and optical tissue phantoms were investigated. To the porcine brain, supplements were added to simulate an edema or high blood content. The tissue phantoms were based on agar, Lipoveneous, ink, blood and gadobutrol (Gd-based MRI contrast agent). The concentrations of phantom ingredients and tissue additives are varied to compare concentration-dependent effects on optical and NMR properties. A 3-tesla whole-body MRI system was used to determine T<sub>1</sub> and T<sub>2</sub> relaxation times. Optical tissue properties, i.e., the spectrally resolved absorption and reduced scattering coefficient, were obtained using a single integrating sphere setup. The observed changes of NMR and optical properties were compared to each other.</p><p><strong>Results: </strong>By adjusting the NMR relaxation times and optical tissue properties of the tissue phantoms to literature values, recipes for human brain tumor, white matter and grey matter tissue phantoms were obtained that mimic these brain tissues simultaneously in both properties. For porcine brain tissue, it was observed that with increasing water concentration in the tissue, both NMR-relaxation times increased, while µ<sub>a</sub> decreased and µ<sub>s</sub>' increased at 635 nm. The addition of blood to porcine brain samples showed a constant T<sub>1</sub>, while T<sub>2</sub> shortened and the absorption coefficient at 635 nm increased.</p><p><strong>Conclusions: </strong>In this investigation, by changing sample contents, notable changes of both NMR relaxation times and optical tissue properties have been observed and their relations examined. The developed dual NMR/optical tissue phantoms can be used in iPDT research, clinical training and demonstrations.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"103968"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139433248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizer. 使用氯素 e6 光敏剂进行光动力疗法期间的肿瘤荧光和氧合监测。
Photodiagnosis and photodynamic therapy Pub Date : 2024-02-01 Epub Date: 2024-01-10 DOI: 10.1016/j.pdpdt.2024.103969
Kanamat Efendiev, Polina Alekseeva, Kirill Linkov, Artem Shiryaev, Tatiana Pisareva, Aida Gilyadova, Igor Reshetov, Arina Voitova, Victor Loschenov
{"title":"Tumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizer.","authors":"Kanamat Efendiev, Polina Alekseeva, Kirill Linkov, Artem Shiryaev, Tatiana Pisareva, Aida Gilyadova, Igor Reshetov, Arina Voitova, Victor Loschenov","doi":"10.1016/j.pdpdt.2024.103969","DOIUrl":"10.1016/j.pdpdt.2024.103969","url":null,"abstract":"<p><strong>Background: </strong>The study is aimed at developing a method for monitoring photodynamic therapy (PDT) of a tumor using chlorin-type photosensitizers (PSs). Lack of monitoring of chlorin e6 (Cе6) photobleaching, hemoglobin oxygenation and blood flow during light exposure can limit the PDT effectiveness.</p><p><strong>Materials and methods: </strong>Phototheranostics includes spectral-fluorescence diagnostics of Ce6 distribution in the NIR range and PDT with simultaneous assessment of hemoglobin oxygenation and tumor blood flow. Fluorescence diagnostics and PDT were performed using the single laser λ<sub>exc</sub>=660 ± 5 nm.</p><p><strong>Results: </strong>Combined spectroscopic PDT monitoring method allowed simultaneous estimation of Ce6 photobleaching, hemoglobin oxygenation and tumor vascular thrombosis during PDT without interrupting the therapeutic light exposure.</p><p><strong>Conclusion: </strong>The developed method of tumor phototheranostics using chlorin-type PSs may make it possible to personalize the duration of therapeutic light exposure during PDT.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"103969"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139428123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Hemoporfin-mediated photodynamic therapy for the treatment of port-wine stain: A multicenter, retrospective study" [Photodiagnosis Photodyn Ther. 2023 Jun;42:103545]. 对 "Hemoporfin 介导的光动力疗法用于治疗葡萄酒色斑:2023 Jun;42:103545] 的更正。
Photodiagnosis and photodynamic therapy Pub Date : 2024-02-01 Epub Date: 2023-12-26 DOI: 10.1016/j.pdpdt.2023.103931
Xiaofeng Zhang, Chen Yuan, Xuemin Xiao, Rui Yin, Hongzhao Lei, Yan Li, Shumao Zheng, Sijian Wen, Dongsheng Li, Xuejun Wang, Zhong Lu, Yunfeng Zhang, Weihui Zeng, Sijin He, Yuzhen Li, Dan Jian, Jun Yang, Hua Zhong, Dawei Han, Xiaoying Chen, Junfeng Zhou, Yantao Cai, Xi Peng, Zhiming Li, Xueying Liu, Tong Lin, Ruzhi Zhang, Guang Li, Yin Zhuang, Ling Liu, Yan Yan, Baoxi Wang
{"title":"Corrigendum to \"Hemoporfin-mediated photodynamic therapy for the treatment of port-wine stain: A multicenter, retrospective study\" [Photodiagnosis Photodyn Ther. 2023 Jun;42:103545].","authors":"Xiaofeng Zhang, Chen Yuan, Xuemin Xiao, Rui Yin, Hongzhao Lei, Yan Li, Shumao Zheng, Sijian Wen, Dongsheng Li, Xuejun Wang, Zhong Lu, Yunfeng Zhang, Weihui Zeng, Sijin He, Yuzhen Li, Dan Jian, Jun Yang, Hua Zhong, Dawei Han, Xiaoying Chen, Junfeng Zhou, Yantao Cai, Xi Peng, Zhiming Li, Xueying Liu, Tong Lin, Ruzhi Zhang, Guang Li, Yin Zhuang, Ling Liu, Yan Yan, Baoxi Wang","doi":"10.1016/j.pdpdt.2023.103931","DOIUrl":"10.1016/j.pdpdt.2023.103931","url":null,"abstract":"","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"103931"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139050027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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