50%与100%重复低强度红光对脉络膜厚度和脉管系统的疗效:一项随机交叉试验。

IF 2.6
Shiran Zhang, Yanxian Chen, Jian Zhang, Zhuoting Zhu, Xiaotong Han, Meng Xuan, Xiaohu Ding, Ruilin Xiong, Yixiong Yuan, Yueye Wang, Cong Li, Lirong Liao, Qiuxia Yin, Yingfeng Zheng, Xiangbin Kong, Mingguang He
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引用次数: 0

摘要

目的:有必要确定50%重复低强度红光治疗(RLRL)是否能达到与标准100%强度相同的脉络膜增厚,在不牺牲近视控制效果的情况下潜在地减少能量消耗。本研究旨在研究每日脉络膜厚度(ChT)和脉管系统,作为近视控制效果的替代结果,RLRL为100%和50%强度。方法:本前瞻性交叉随机对照试验招募18-40岁近视患者。该研究包括两个为期4周的治疗阶段,中间有4周的洗脱期,参与者被随机分配到100%-50%或50%-100% rrrl治疗序列。主要结果是使用扫描源光学相干断层扫描每天测量的中央凹下ChT (sfChT)和平均黄斑ChT (mChT)的变化。次要结果包括黄斑脉络膜血管。结果:该研究包括27名参与者(平均年龄21.2岁)。治疗1个月后,50%和100% RLRL均导致sfChT、mChT和乳头周围ChT显著增加,组间无显著差异。脉络膜增厚在治疗期间逐渐发展,并且ChT和血管参数的日变化曲线具有可比性。结论:本研究表明,50% RLRL和100% RLRL均产生相似的脉络膜增厚,表明50% RLRL在减少能量消耗的情况下可能具有相当的近视控制效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy of 50% vs. 100% Intensity Repeated Low-Level Red-Light on Choroidal Thickness and Vasculature: A Randomized Crossover Trial.

Purpose: It is essential to determine if 50% repeated low-level red-light therapy (RLRL) can achieve the same choroidal thickening as the standard 100% intensity, potentially reducing energy use without sacrificing efficacy in myopia control. This study aimed to investigate the daily choroidal thickness (ChT) and vasculature, as surrogate outcomes for myopia control efficacy, with the RLRL at 100% and 50% intensity.

Methods: This prospective crossover randomized controlled trial recruited adults aged 18-40 years with myopia. The study consisted of two 4-week treatment phases separated by a 4-week washout period, with participants randomly assigned to either a 100%-50% or 50%-100% RLRL treatment sequence. The primary outcomes were changes in subfoveal ChT (sfChT) and mean macular ChT (mChT) measured daily using swept-source optical coherence tomography. Secondary outcomes included macular choroidal vasculature.

Results: The study included 27 participants (mean age, 21.2 years). After 1 month of treatment, both 50% and 100% RLRL resulted in significant increases in sfChT, mChT, and peripapillary ChT, with no significant differences between the groups. Choroidal thickening developed gradually over the treatment period, and daily change profiles in ChT and vasculature parameters were comparable.

Conclusions: This study demonstrates that both 50% and 100% RLRL produced similar choroidal thickening, suggesting that 50% RLRL may offer comparable myopia control efficacy with reduced energy usage.

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