Photodiagnosis and photodynamic therapy最新文献

{"title":"Photobiomodulation as a Potential Adjunct to Improve the Predictability of Mandibular Incisor Autotransplantation to the Maxillary Lateral Incisor Site in Orthodontic Patients.","authors":"Rashin Bahrami","doi":"10.1016/j.pdpdt.2026.105694","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2026.105694","url":null,"abstract":"","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105694"},"PeriodicalIF":2.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation and the Wnt/β-Catenin Pathway in Apexogenesis: Rationale and Evidence Gaps.","authors":"Rashin Bahrami, Zahra Kiyamehr, Maryam Pourhajibagher, Abbas Bahador","doi":"10.1016/j.pdpdt.2026.105693","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2026.105693","url":null,"abstract":"<p><p>Apexogenesis is a vital pulp therapy that preserves vascularized pulp in immature teeth and relies on dental pulp stem cells (DPSCs) and stem cells from the apical papilla (SCAPs) for continued root growth and apical closure. Wnt/β-catenin signaling has an established role in odontoblast differentiation, reparative dentinogenesis, and root development, although normal root development requires regulated rather than simply increased Wnt activity. Photobiomodulation therapy (PBMT) is proposed to act through mitochondrial photoreception, and in vitro studies report increased expression of odontogenic/osteogenic markers and angiogenic factors (VEGF, TGF-β2) in DPSCs and SCAPs. Because these markers overlap with Wnt/β-catenin targets, a link between PBMT and this pathway has been hypothesized but not tested in these cells. This review addresses three questions: the role of Wnt/β-catenin signaling in root development and dentin repair; the mechanism that could link PBMT to this pathway; and the in vitro evidence for PBMT effects on DPSCs and SCAPs and its consistency. The evidence is heterogeneous and limited. Increased odontogenic/osteogenic differentiation was the most consistent finding. Reported effects on \"proliferation\" were inconsistent and were estimated mainly by MTT, a metabolic assay that does not measure cell division; no study used a clonogenic assay, and only one performed direct cell counts. No superior wavelength or fluence was identified. No study has examined PBMT-induced modulation of Wnt/β-catenin signaling in DPSCs or SCAPs, and the markers involved are not pathway-specific. Therapeutic benefit in apexogenesis therefore remains unproven; direct mechanistic studies, light-delivery studies through dentin, and animal models are priorities.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105693"},"PeriodicalIF":2.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic capability of perimetry and optical coherence tomography based retinal thickness measurements in diabetic patients with no or mild retinopathy.","authors":"Nasrin Moghadas Sharif, Faezeh Noferesti, Maliheh Karimpour, Ata Asiaei","doi":"10.1016/j.pdpdt.2026.105692","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2026.105692","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare and evaluate the diagnostic potential of visual field parameters and different retinal layers thicknesses among diabetic patients with and without diabetic retinopathy and non-diabetic controls.</p><p><strong>Methods: </strong>A total of 174 participants were enrolled and divided equally into three groups of 58 subjects: (1) healthy controls, (2) diabetic patients without diabetic retinopathy (NoDR), and (3) diabetic patients with mild non-proliferative diabetic retinopathy (NPDR). Retinal layer thicknesses (eight layers × five macular sectors) and visual field (mean deviation, MD; pattern standard deviation, PSD) were compared using one-way ANOVA with Tukey post-hoc testing. Pearson correlations between MD/PSD and retinal layer thickness were computed to test structure-function association.</p><p><strong>Results: </strong>Temporal NFL thickness was markedly greater in NPDR (25.14 ± 8.62 µm) than in NoDR (19.43 ± 4.17 µm) or controls (19.34 ± 5.15 µm; P < 0.001), and this difference persisted after age adjustment (P < 0.001). MD showed good diagnostic performance for NoDR vs control (AUC 0.766) and NPDR vs control (AUC 0.876), outperforming PSD (AUC 0.646 and 0.719, respectively); the NoDR-vs-control MD difference remained significant after age adjustment (P = 0.011) but was substantially attenuated, and the PSD group difference was fully explained by age (age-adjusted P = 0.80). No meaningful correlation was found between MD/PSD and any retinal layer thickness (all |r| < 0.21).</p><p><strong>Conclusion: </strong>Temporal NFL thickening in NPDR and reduced visual field MD represent the most robust structural and functional abnormalities in this study.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105692"},"PeriodicalIF":2.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation on the impact of outdoor exercise on retinal cone photoreceptor mosaic using adaptive optics scanning laser ophthalmoscopy.","authors":"Jinglin Huang, TianHao Qu, Yanming Huang, Yuanyuan Liu, Siyue Chen, Yun Zhu, Chen Liu, Jiqiu Li, Zhiyong Sun, Wei Zhou, Hua Yan","doi":"10.1016/j.pdpdt.2026.105691","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2026.105691","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the impact of exercise and sunlight exposure on the cone photoreceptor mosaic using adaptive optics scanning laser ophthalmoscopy (AOSLO) and to identify associated factors.</p><p><strong>Methods: </strong>This cross-sectional, observational study involved 114 participants (204 eyes) from Tianjin University of Sport who completed comprehensive evaluations, including epidemiological questionnaires, ophthalmic examinations, and AOSLO examinations. Exercise and sunlight exposure were analyzed as the main independent factors, and their joint effect was assessed with mixed-effects models. The high-exercise group was defined as ≥2 hours of exercise per day continuously for 3 years, and the high-sunlight group as ≥2 hours of sunlight exposure per day. Participants were then classified four groups in a 2 × 2 design: high exercise + low sunlight, high sunlight + low exercise, high exercise + high sunlight, and low exercise + low sunlight (reference group). The reference group was used to estimate the effects of exercise, sunlight, and their combination.</p><p><strong>Results: </strong>In independent factors analysis, there was no significant difference in the cone morphology between the high-exercise group and the high-sunlight-exposure group compared with control groups, respectively (P > 0.01). In the joint effect analysis, high-exercise and high-sunlight-exposed significantly increased cone density at the eccentricity 1.5°-2.5° (β= 3252.516, 2389.211, 1853.936, P=0.001, 0.002, 0.003). Axial length mediated this association (P<0.001).</p><p><strong>Conclusions: </strong>Compared to those receive less exercise and sunlight, participants accustomed to more than 2 hours of daily outdoor exercise had higher cone density. This suggests that outdoor exercise is related to cone photoreceptor health, whereas either sunlight exposure alone or exercise alone failed to produce the combined effect of outdoor exercise.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105691"},"PeriodicalIF":2.6,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate and residual antimicrobial effects of adjunctive photodynamic therapy on Enterococcus faecalis-infected human root canals.","authors":"Antonio José Pecinali Santos, Catherine Bandiera Zaleski, José Antônio Poli de Figueiredo, Sílvia Dias de Oliveira, Maximiliano Schünke Gomes","doi":"10.1016/j.pdpdt.2026.105690","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2026.105690","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the immediate and residual antimicrobial effects of adjunctive photodynamic therapy (PDT) associated with chemo-mechanical preparation (CMP) in Enterococcus faecalis-infected human root canals, with particular emphasis on whether PDT provides a persistent antimicrobial effect after treatment.</p><p><strong>Materials and methods: </strong>Sixty-four extracted single-rooted human teeth were infected with E. faecalis and randomly assigned to four experimental groups according to treatment protocol and evaluation time: CMP-immediate (n=10), CMP-15d (n=10), CMP+PDT-immediate (n=10), and CMP+PDT-15d (n=10). Positive controls consisted of infected, untreated specimens evaluated immediately (n=4) or after 15 days (n=4), whereas negative controls consisted of non-infected specimens subjected to the corresponding experimental procedures (n=16). Microbiological samples were collected before treatment and either immediately or 15 days after treatment. Antimicrobial efficacy was assessed by CFU/mL counts and expressed as percentage bacterial reduction. Root canal surface contamination was evaluated by scanning electron microscopy (SEM). Percentage bacterial reduction and SEM contamination scores were analyzed using the Kruskal-Wallis test followed by Dunn's multiple-comparisons test (α=0.05).</p><p><strong>Results: </strong>All treatment protocols produced marked bacterial reduction (>99%) compared with baseline. Although the CMP+PDT groups showed numerically greater bacterial reduction and a higher frequency of specimens with undetectable bacterial growth than the CMP groups, these differences were not statistically significant (p>0.05). No residual antimicrobial benefit attributable to PDT was detected after the 15-day observation period. SEM analysis confirmed significantly lower contamination scores in treated specimens than in untreated controls but showed no consistent differences between CMP alone and CMP+PDT.</p><p><strong>Conclusions: </strong>Adjunctive PDT did not provide a statistically significant additional antimicrobial benefit over conventional chemo-mechanical preparation, either immediately after treatment or after 15 days. No residual antimicrobial effect attributable to PDT was detected.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105690"},"PeriodicalIF":2.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choroidal Microvascular Alterations on Ultra-Widefield Swept-Source OCTA in Type 2 Diabetes: Associations with Outer Retinal Structural Changes and Systemic Risk Markers.","authors":"Shurong Guo, Zhenping Li, Tai Zhang, Qihang Zhou, Fanying Jiang, Yunjiao Zhao, Wanqing He, Fan Yang, Yuqing Lan","doi":"10.1016/j.pdpdt.2026.105689","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2026.105689","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize choroidal microvascular alterations in diabetes without diabetic retinopathy (NDR) or mild non-proliferative diabetic retinopathy (NPDR) and evaluate associations with retinal structural changes and systemic risk markers.</p><p><strong>Methods: </strong>This retrospective cross-sectional study included 209 healthy controls, 203 patients with NDR, and 199 treatment-naïve patients with mild NPDR. Ultra-widefield swept-source optical coherence tomography angiography (UWF-SS-OCTA) quantified choroidal and retinal parameters. Systemic markers, including blood pressure, HbA1c, lipid profiles, and renal markers, were assessed in diabetic participants. Correlation analyses assessed associations of choroidal microvascular parameters with retinal structural changes in the overall population and diabetic participants. Multivariable regression evaluated associations with systemic risk markers, with NDR-specific sensitivity analyses.</p><p><strong>Results: </strong>Choriocapillaris vascular density (CC-VD) and choroidal vascularity index (CVI) were reduced in NDR versus controls, whereas retinal vascular density decreased only in NPDR (all p < 0.05). Outer retinal thickness and volume increased in NDR. In the overall cohort, both were inversely correlated with CC-VD and CVI (r = -0.25 to -0.30, all p < 0.001), with associations remaining significant in diabetic participants. Systolic blood pressure ≥140 mmHg and urinary albumin excretion rate >20 μg/min were independently associated with lower CC-VD (β = -1.03 and -1.36, respectively), whereas cystatin C >1.09 mg/L was associated with lower CVI (β = -0.92; all p < 0.05). These systemic associations persisted in NDR-specific analyses.</p><p><strong>Conclusion: </strong>UWF-SS-OCTA revealed reduced CC-VD and CVI in diabetes without clinically apparent DR. Associations with outer retinal thickening and systemic risk markers suggest links among choroidal microvascular alterations, retinal structural changes, and systemic risk.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105689"},"PeriodicalIF":2.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epivascular Glia and Macular Pigment Changes after Faricimab or Aflibercept during the Loading Phase in Diabetic Macular Edema: A Prospective Non-randomized Pilot Study.","authors":"Gilda Cennamo, Michele Rinaldi, Erica Caporale, Fabiana Iorio, Davide Tramontano, Ciro Costagliola","doi":"10.1016/j.pdpdt.2026.105687","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2026.105687","url":null,"abstract":"<p><strong>Purpose: </strong>To explore short-term changes in epivascular glia (EVG), macular pigment optical density (MPOD), visual acuity, and retinal thickness after faricimab or aflibercept in treatment-naive eyes with center-involving diabetic macular edema (DME).</p><p><strong>Methods: </strong>This prospective, non-randomized pilot study included 30 eyes with DME and EVG on en face optical coherence tomography. Fifteen eyes received three monthly injections of faricimab 6 mg and 15 received aflibercept 2 mg. The primary exploratory outcome was complete EVG regression after loading. Secondary outcomes included best-corrected visual acuity (BCVA), central macular thickness (CMT), MPOD, fluid resolution, and resolution of traction-related abnormalities.</p><p><strong>Results: </strong>Complete EVG regression occurred in 12/15 eyes (80.0%) with faricimab and 6/15 (40.0%) with aflibercept (Fisher's exact p=0.060). Resolution of traction- related abnormalities occurred in 11/15 (73.3%) and 5/15 eyes (33.3%), respectively (p=0.066). Post-loading CMT was 274.5 ± 61.3 versus 328.7 ± 72.4 µm (unadjusted p=0.035), MPOD was 0.46 ± 0.07 versus 0.39 ± 0.08 (unadjusted p=0.017), and BCVA was 0.27 ± 0.14 versus 0.36 ± 0.16 logMAR (p=0.112).</p><p><strong>Conclusions: </strong>EVG and traction- related outcomes were numerically more favorable with faricimab but were not statistically significant. Exploratory anatomical and MPOD differences require confirmation in larger randomized studies.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105687"},"PeriodicalIF":2.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics, Risk Factors, and Prognosis of Intrapapillary Hemorrhage and Peripapillary Subretinal Hemorrhage: A Systematic Review.","authors":"Yiran Jia, Haiying Zhou, Libin Jiang, Hai-Long He","doi":"10.1016/j.pdpdt.2026.105684","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2026.105684","url":null,"abstract":"<p><strong>Purpose: </strong>To systematically summarize the clinical characteristics, anatomical risk factors, imaging findings, pathophysiological mechanisms, and prognosis of intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage (IHAPSH) and peripapillary subretinal hemorrhage (PPSH), and to provide evidence-based guidance for diagnosis and management.</p><p><strong>Methods: </strong>Following PRISMA guidelines, PubMed, Web of Science, Elsevier, China National Knowledge Infrastructure (CNKI), and Wanfang were searched from inception to June 2026. Observational studies, case series, and case reports of IHAPSH, PPSH, or isolated optic disc hemorrhage were included. Data on demographics, anatomical features, precipitating factors, imaging findings, management, and outcomes were qualitatively synthesized.</p><p><strong>Results: </strong>Twenty-one studies involving 176 patients (181 eyes) were included. IHAPSH/PPSH predominantly affected young and middle-aged myopic Asian individuals. Myopia, small crowded optic discs, and optic disc tilt were consistently reported, suggesting they are the principal predisposing factors. In contrast, Valsalva-related triggers were infrequent, and vitreoretinal traction was rarely identified on imaging, arguing against either as the primary pathogenic mechanism. Across all evaluable eyes, myopia was present in 98.34%, small optic discs in 94.91%, optic disc tilt in 95.52%, identifiable Valsalva triggers in 12.78%, and vitreoretinal traction in 2.80%. The most common presentations were optic disc hemorrhage with peripapillary subretinal hemorrhage (40.80%) and hemorrhage with vitreous hemorrhage (36.20%), predominantly involving the nasal peripapillary region. Peripapillary hyperreflective ovoid mass-like structures (PHOMS) were frequently observed, whereas optic disc drusen were uncommon. The disease was typically unilateral, self-limiting, and associated with spontaneous hemorrhage resolution, favorable visual outcomes, and rare recurrence.</p><p><strong>Conclusions: </strong>IHAPSH and PPSH are benign, self-limiting hemorrhagic disorders closely associated with myopia-related optic disc abnormalities and transient hemodynamic triggers. Myopia, crowded optic discs, and optic disc tilt appear to be the major predisposing factors. Recognition of their characteristic clinical and imaging features is essential for accurate diagnosis and avoidance of unnecessary interventions.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105684"},"PeriodicalIF":2.6,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SkinFusionNet: Multi-backbone spatial fusion for robust and explainable melanoma classification.","authors":"Faysal Ahmmed, Resadus Salehin Rafsan, Muhtadi Mansib, Airin Akther, Ainea Esrat Esika, Mohaimen-Bin-Noor","doi":"10.1016/j.pdpdt.2026.105668","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2026.105668","url":null,"abstract":"<p><p>Automated melanoma detection from dermoscopic images remains a critical yet unresolved challenge due to substantial dataset heterogeneity, artifact contamination, and limited model generalization across clinical sources. Existing deep learning methods commonly rely on single-dataset training, single-backbone architectures, or post-hoc interpretability, which restrict robustness and clinical trustworthiness. In this work, we present a novel multi-backbone spatial fusion framework that integrates DenseNet121, EfficientNetV2-B1, and ResNet152V2 to learn complementary mid-level representations from heterogeneous data. The proposed approach uniquely performs spatial feature fusion rather than prediction-level ensembling, enabling richer lesion-aware feature integration. A domain-informed preprocessing pipeline, combining advanced hair removal, illumination correction in LAB space, and adaptive contrast enhancement, further reduces artifact-induced bias. The model is trained on a large merged cohort of approximately 30,000 images from five public datasets using focal loss and evaluated through bootstrap validation. Comprehensive explainability analysis using Grad-CAM++ and Score-CAM confirms consistent lesion-focused attention. The proposed system achieves 94.46% test accuracy with stable performance across bootstrap resamples (95% CI: 93.66%-95.30%), demonstrating enhanced robustness, reliability, and clinical applicability for automated melanoma classification.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105668"},"PeriodicalIF":2.6,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Raman spectroscopy aided evaluation of basal cell carcinoma diagnosis: A case report.","authors":"Minfeng Wu, Shiyi Yang, Zhe Zheng, Shaojun Fang, Na Yu, Rongyi Zhu, Rongjun Zhang","doi":"10.1016/j.pdpdt.2026.105608","DOIUrl":"10.1016/j.pdpdt.2026.105608","url":null,"abstract":"<p><p>Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer, and primarily diagnosed by invasive and time-consuming histopathological biopsy, highlighting the need for rapid, non-invasive adjunctive tools. We report the case of a 93-year-old patient presenting with a suspicious scalp lesion who underwent dermoscopy, Wood's lamp examination, and in vivo Raman spectroscopy prior to biopsy. Conventional clinical examinations suggested a malignant lesion but were unable to determine the specific tumor type, whereas Raman spectra displayed high similarity to former BCC cases and clear separation from actinic keratosis cases by principal component analysis. Characteristic Raman peaks associated with collagen (936 and 1657 cm⁻¹), glycine (1204 cm⁻¹), and phospholipids (1445 cm⁻¹) were identified, consistent with molecular alterations reported in BCC. Although the initial histopathological assessment suggested a benign lesion, subsequent expert review together with immunohistochemical analysis confirmed BCC, aligning with the Raman spectroscopy findings. This case further demonstrates the potential of Raman spectroscopy to complement conventional histopathology and assist in the identification of diagnostically challenging BCC cases.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105608"},"PeriodicalIF":2.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}