Photodiagnosis and photodynamic therapy最新文献

{"title":"Clinical efficacy of photodynamic therapy combined with CO₂ laser in the treatment of vulvar squamous intraepithelial lesions.","authors":"Jingyi Mu, Yunfeng Zhang, Guiqin Chen, Yongjie Li, Yue Wang","doi":"10.1016/j.pdpdt.2025.104744","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104744","url":null,"abstract":"<p><strong>Background: </strong>Comprehensive research data on the combination of 5-aminolevulinic acid (5-ALA) photodynamic therapy (PDT) and CO₂ laser treatment in the management of vulvar squamous intraepithelial lesions (VSIL) remains limited. This study evaluates the efficacy and adverse reactions associated with the combination treatment for VSIL.</p><p><strong>Methods: </strong>This study was a retrospective study. The subjects were 165 patients diagnosed with VSIL in the People's Hospital of Zhengzhou University. According to the patients' personal choice, they were divided into 5-ALA PDT group (n = 37), CO2 laser group (n = 78) and 5-ALA PDT combined with CO2 laser group (n = 50). The general condition, treatment times and adverse reactions of patients in each group were analyzed. All patients underwent HPV, TCT and colposcopy at 3 months and 6 months after treatment to evaluate the therapeutic effect, and biopsy was performed again if necessary.</p><p><strong>Results: </strong>There was no statistically significant difference in the HPV negative conversion rates and lesions complete remission (CR) rates of both vulvar low-grade squamous intraepithelial lesions (VLSIL) and vulvar high-grade squamous intraepithelial lesions (VHSIL) patients among the three groups at 3 months after treatment. Regarding VLSIL, the HPV negative conversion rates for both the 5-ALA PDT group (51.7%) and the combination group (51.9%) were significantly higher than the CO₂ laser group (27.6%) at six months post-treatment. Regarding VHSIL, the HPV negative conversion rates for the 5-ALA PDT group (62.5%) and the combination group (60.9%) were significantly higher than the CO₂ laser group (25.0%) at 6 months post-treatment. However, recurrence rates did not differ significantly among the three groups. The combination group required fewer treatment sessions compared to the single treatment groups. The CO₂ laser group experienced the mildest adverse reactions, followed by the combined treatment group, while the 5-ALA PDT group exhibited more pronounced reactions.</p><p><strong>Conclusion: </strong>The integration of 5-ALA PDT with CO₂ laser therapy not only reduces the overall treatment duration but also enhances treatment efficacy. Therefore, it is a promising option for treating VSIL.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104744"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Different 5-Aminolevulinic Acid Photodynamic Therapy Regimens in Managing HSIL/CIN2 Among Reproductive-Age Women: A Retrospective Study.","authors":"Luting Wang, Yingting Wei, Anyue Wu, Zubei Hong, Liying Gu, Lihua Qiu","doi":"10.1016/j.pdpdt.2025.104749","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104749","url":null,"abstract":"<p><strong>Background: </strong>High-grade squamous intraepithelial lesion (HSIL) is a precancerous lesion that requires timely and effective intervention. Photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) has emerged as a non-invasive, fertility-preserving alternative to excisional procedures. However, the ALA-PDT regimen remains to be optimized.</p><p><strong>Objectives: </strong>To compare the efficacy and safety of three treatment strategies-three-session PDT (3PDT), six-session PDT (6PDT), and a single CO₂ laser ablation combined with six-session PDT (Laser + 6PDT)-for the management of cervical intraepithelial neoplasia grade 2 (HSIL/CIN2) in reproductive-age women.</p><p><strong>Methods: </strong>This retrospective cohort study included 158 women aged 20-45 years with biopsy-confirmed cervical HSIL/CIN2. Participants received one of three regimens: 3PDT (n = 49), 6PDT (n = 47), or Laser + 6PDT (n = 54). Lesion regression and high-risk HPV (hrHPV) clearance were assessed at 3-6 and 9-12 months post-treatment. A subset of patients was followed up to 18-24 months. Adverse events were also recorded.</p><p><strong>Results: </strong>At the 3-6 months follow-up, the complete remission (CR) rates were 67.35% (3PDT), 74.47% (6PDT), and 79.63% (Laser + 6PDT), with hrHPV clearance rates of 67.35%, 72.34%, and 77.78%, respectively. Differences among groups were not statistically significant (P > 0.05). By 9-12 months, CR rates reached ≥90% in all groups, and hrHPV clearance exceeded 80%. At 18-24 months, hrHPV clearance reached 100% in the 6PDT group, while three patients in the 3PDT group experienced HPV recurrence. All regimens were well tolerated, with only mild adverse events reported.</p><p><strong>Conclusion: </strong>All three ALA-PDT-based regimens were effective and safe in treating HSIL/CIN2 in reproductive-age women. Although not statistically significant, six-session PDT with or without laser pretreatment showed a trend toward higher lesion remission and hrHPV clearance. Individualized treatment decisions based on disease severity, patient preference, and cost factors are recommended to optimize outcomes.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104749"},"PeriodicalIF":2.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precise diagnosis of Small Cell and Non-Small Cell Lung Cancer based on Raman spectroscopy.","authors":"Wendong Sun, Liwei Liao, Ruochen Zhu, Yuexiang Wang, Keren Chen, Gang Hou, Shuo Chen","doi":"10.1016/j.pdpdt.2025.104747","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104747","url":null,"abstract":"<p><p>Lung cancer has been the second most prevalent cancer globally and the leading cause of cancer-related mortality. Due to the similar clinical symptoms but different treatment protocols for different subtypes of lung cancer, precise diagnosis between small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) is of paramount importance for guiding treatment and improving outcomes. In this study, we explored an innovative diagnostic approach that combines Raman spectroscopy with partial least squares analysis and linear discriminant analysis (PLS-LDA) to identify the presence of lung cancer and differentiate its specific subtype. Based on biochemical analysis results, statistically significant differences between SCLC and NSCLC groups were observed in levels of amino acids, nucleic acids, and collagen. In addition, high diagnostic accuracy rates of up to 100% for in vitro cultured cell samples and 93.75% for ex-vivo tissue samples were achieved to differentiate SCLC and NSCLC. The proposed method offers great potential in the precise diagnosis of lung cancer with different histologic subtypes, benefiting timely and rational treatment for lung cancer patients.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104747"},"PeriodicalIF":2.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ytterbium fiber laser, Malachite green activated low-level laser therapy on the surface topography, contact angle, and shear bond strength of Lithium disilicate ceramic bonded to hydroxyapatite modified self-adhesive resin cement.","authors":"Eman M Alhamdan","doi":"10.1016/j.pdpdt.2025.104737","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104737","url":null,"abstract":"<p><strong>Aims: </strong>Impact of different pretreatment regimes i.e., Hydrofluoric (HF) acid, ytterbium fiber laser (YFL), Malachite green (MG) activated low level laser therapy (LLLT) on the surface topography, contact angle, and shear bond strength (SBS) of Lithium disilicate ceramic (LDC) bonded to 1% hydroxyapatite nanoparticles (HANPs) incorporated self-adhesive resin cement (SARC) MATERIAL AND METHODS: Seventy-Eight LDC discs were obtained and were arbitrarily assigned into three groups based on different surface conditioning techniques (n=26) Group 1: HF Acid, Group 2: YFL and Group 3: MG-LLLT. A contact angle measurement was performed on five samples from each group using a goniometer. A scanning electron microscope (SEM) analyzed the surface topographic changes after different pretreatments. The SARC was modified using 1% HANP, followed by the degree of conversion (DC). Twenty discs from each group were further divided into two subgroups based on the application of the type of SARC, Unmodified SARC (A) and HANP-modified SARC (B) (n=10). Both the cements were built on the LDC discs and were subjected to SBS and failure mode testing through the utilization of a universal testing machine and a stereomicroscope. The means of the contact angle and SBS were subjected to a one-way analysis of variance (ANOVA) followed by post hoc Tukey's test (p = 0.05).</p><p><strong>Result: </strong>Group 3 MG-LLLT-treated LDC discs achieved the highest contact angle (32.2 ± 1.9). Whereas Group 2 (YFL) (9.6±0.9) conditioned discs presented the lowest contact angle. The specimens categorized under Group 2B (YFL+HANPs modified SARC) (11.22±1.1 MPa) achieved the highest bond strength. Conversely, the LDC discs within Group 3A (MG-LLLT + SARC) displayed the lowest bond values (5.29 ± 0.8 MPa). Moreover, 1% HANPs incorporated SARC displayed significantly higher DC (61.6±0.72%) than that of the control (52.3±0.68) (p˂0.05).</p><p><strong>Conclusion: </strong>Ytterbium fiber laser can be used as a substitute for conditioning lithium disilicate ceramics, as it reduces the contact angle and improves the bond strength of adhesive resin cement. Hydroxyapatite nanoparticles incorporated into the self-adhesive resin cement resulted in a higher degree of conversion and shear bond strength to the lithium disilicate ceramic.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104737"},"PeriodicalIF":2.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Use of Photodynamic Therapy for Refractory Cutaneous Langerhans Cell Histiocytosis: A Case Report.","authors":"Chi-Tong Lee, Ya-Wen Tsai, Fang-Ying Wang","doi":"10.1016/j.pdpdt.2025.104748","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104748","url":null,"abstract":"<p><p>Cutaneous manifestations of Langerhans cell histiocytosis (LCH) are diverse and may mimic various dermatologic conditions, often leading to diagnostic challenges. We report a case of a 44-year-old woman who presented with multiple erythematous papules on the scalp, associated with tenderness and pruritus persisting for several months. Histopathological examination and immunohistochemical staining confirmed cutaneous LCH, consistent with her known systemic LCH involving the pituitary gland and sternum. An initial systemic chemotherapy protocol comprising weekly vinblastine and prednisolone, followed by an eight-week consolidation phase, failed to elicit a therapeutic response. Subsequent treatment with low-dose cytarabine (100 mg/m²), administered as a 5-day course every 28 days, also failed to achieve disease control. Local scalp radiotherapy yielded partial improvement but was limited by adverse effects. Due to chemoresistance and intolerance to radiotherapy, 5-aminolevulinic acid (5-ALA) based photodynamic therapy (PDT) was initiated. PDT led to marked clinical improvement of cutaneous lesions with minimal adverse effects. However, disease recurrence necessitated additional PDT sessions, which remained effective upon relapse. This case highlights the potential role of PDT as a safe and effective alternative for managing cutaneous LCH refractory to conventional therapies.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104748"},"PeriodicalIF":2.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel quantitative analysis of relative peripheral refraction changes in orthokeratology and their relationship with one-year axial elongation.","authors":"Ke Wen, Yifan Wu, Bi Yang, Longqian Liu","doi":"10.1016/j.pdpdt.2025.104739","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104739","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate changes in relative peripheral refraction (RPR) and their associations with axial length (AL) growth after one year of orthokeratology (ortho-k) therapy.</p><p><strong>Methods: </strong>This prospective cohort study included 60 myopic children aged 8-15 years. RPR and AL were measured at baseline and 12 months after ortho-k therapy. Total RPR was measured via multispectral refraction topography (MRT) in the 53° fundus field of view, and then was divided into specific annuli (0-10°, 10-20°, 20-30°, 30-40°, 40-50° and 50-53°) and quadrants (superior, inferior, temporal and nasal). Linear regression analyses quantified associations between RPR changes and AL elongation.</p><p><strong>Results: </strong>Ultimately, 80.0% of the participants were analysed. The total RPR was 0.64 ± 0.26 D at baseline and -0.35 ± 0.64 D at 12 months. Ortho-k therapy induced myopic shifts in all subregions (all p < 0.05). Additionally, hyperopic RPRs within the 50° region and in the superior, inferior and nasal parts of the retina became myopic. These myopes had an asymmetric RPR in the vertical retina both before and after ortho-k treatment but a symmetric RPR in the horizontal retina, which changed after treatment. Multivariate linear regression analyses revealed that the baseline AL and RPR changes in the 30-40° region and in the inferior retina were independently associated with AL elongation during one-year of ortho-k lens wear (all p < 0.05).</p><p><strong>Conclusions: </strong>The more myopic shifts of RPR induced by ortho-k treatment in the 30° to 40° region and in the inferior retina, the more effective control of axial elongation.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104739"},"PeriodicalIF":2.6,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting Ferroptosis of Keloid Fibroblasts: A Key Mechanism Underlying the Efficacy of 5-Aminolevulinic Acid Photodynamic Therapy for Keloids.","authors":"Jiaying Zhang, Yahui Feng, Ning Zhang, Xiaoqing Wang, Dongmei Li, Dongmei Shi","doi":"10.1016/j.pdpdt.2025.104736","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104736","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for keloid treatment and explore its molecular mechanisms.</p><p><strong>Methods: </strong>Nine keloid patients were enrolled between May 2024 and March 2025. All patients received ALA-PDT, with therapeutic efficacy systematically evaluated for keloid lesions. Keloid fibroblasts (KFs) isolated from lesions were subsequently treated with ALA-PDT. Mitochondrial dehydrogenase activity, collagen metabolism, and matrix metalloproteinase (MMP) expression were assessed in KFs at gene and protein levels. Reactive oxygen species (ROS) production and ferroptosis-associated molecular expression in ALA-PDT-treated KFs were also investigated to explore molecular mechanisms.</p><p><strong>Results: </strong>Clinically, four sessions of ALA-PDT (administered at 14-day intervals) reduced keloid lesion volume by 45%. Histopathological analysis showed significant collagen architecture remodeling. ALA-PDT disrupted keloid fibroblasts ultrastructure, evidenced by mitochondrial swelling, autophagosome formation, and membrane blebbing, with a 3.2-fold increase in morphological changes post-treatment. The inhibitory effect of ALA-PDT on KFs mitochondrial dehydrogenase activity was ALA dose-dependent. Mechanistically, ALA-PDT inhibited collagen expression via MMP upregulation. Additionally, ALA-PDT directly induced ferroptosis in KFs, evidenced by characteristic structural destruction. Further studies showed ALA-PDT significantly activated the ferroptosis signaling pathway in KFs, modulating key molecules (GPX4, ACSL4, NOX-1, SLC7A11, NCOA4). ALA-PDT also upregulated ferroptosis-associated factors (MMP-9, MMP-1, CCL-2), promoted ROS production, and induced ferroptosis in KFs.</p><p><strong>Conclusion: </strong>ALA-PDT provides an effective and safe keloid treatment. Its mechanism involves inducing ferroptosis via ROS production and modulating the extracellular matrix to restore collagen balance. By selectively targeting KFs while sparing normal fibroblasts, ALA-PDT demonstrates remarkable therapeutic precision.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104736"},"PeriodicalIF":2.6,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofluorescence imaging as a valid alternative for dental calculus detection Biofluorescence imaging as a valid alternative for dental calculus detection.","authors":"Sun-Young Lee, Hyung-Suk Lee, Eun-Song Lee, Hoi-In Jung, Baek-Il Kim","doi":"10.1016/j.pdpdt.2025.104738","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104738","url":null,"abstract":"<p><strong>Background: </strong>Dental calculus is a major contributor to periodontal disease, and its effective removal depends on accurate detection. This study aimed to evaluate the detectability of dental calculus using quantitative biofluorescence imaging (BFI) and to assess its diagnostic accuracy compared to white-light imaging (WLI) and conventional visual-tactile (VT) examination.</p><p><strong>Methods: </strong>Ten adults were enrolled, and 100 tooth surfaces from the buccal side of maxillary molars and the ligual side of mandibular anterior teeth were examined at three sites (mesial, central, distal), yielding 300 sites. After excluding 15 unsuitable sites, 285 were analyzed. Each site was imaged using WLI and BFI with a biofluorescence-enabled intraoral camera (Qraypen C®, AIOBIO, Korea). VT examination served as the reference standard, and sites were categorized as No calculus, Initial calculus, or Advanced calculus. Color difference (ΔE) and red biofluorescence intensity (ΔR) were measured. Diagnostic accuracy, including sensitivity, specificity, false-positive, and false-negative rates, was compared between imaging modalities.</p><p><strong>Results: </strong>BFI showed significantly higher ΔE values than WLI, with values increasing by calculus severity (p < 0.001). ΔR also rose with accumulation: 2.75% (No calculus), 6.06% (Initial), 15.58% (Advanced). Detection accuracy improved with WLI + BFI versus WLI alone: sensitivity (0.84 vs. 0.61), specificity (1.00 vs. 0.91), and false-negative rate (16.1% vs. 38.7%).</p><p><strong>Conclusion: </strong>Biofluorescence imaging enables more distinct detection of dental calculus than white-light imaging, with higher sensitivity and specificity. This method not only identifies calculus presence but also allows quantitative assessment of its accumulation, enhancing diagnostic accuracy.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104738"},"PeriodicalIF":2.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the efficacy of Orthokeratology and Highly Aspherical Lenslets in slowing myopia progression.","authors":"Chao Li, Fan Yang, WeiFen Gong","doi":"10.1016/j.pdpdt.2025.104733","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104733","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of Highly Aspherical Lenslets (HAL) in slowing myopia progression among schoolchildren and compare it to orthokeratology.</p><p><strong>Methods: </strong>This retrospective study included 475 myopic patients aged 6 to 15 years, with myopia ranging from -0.75 to -5.75D. Only the right eye of each subject was analyzed. Cycloplegic refraction and axial length(AL) measurements were performed at baseline and after 6 months (only AL measurements were performed in the orthokeratology group after 6 months).</p><p><strong>Results: </strong>After 6 months, HAL lenses(0.00 [-0.25,0.00]D) significantly delayed spherical equivalent refraction (SER) myopia progression compared to single vision (SV) lenses(-0.50 [-0.75,-0.25]D) in both low and moderate myopia(P<0.001). Additionally, both HAL (0.06±0.10mm) and orthokeratology(0.04±0.13mm) lenses significantly reduced AL elongation compared to SV lenses(0.25±0.16mm,(P<0.001). However, there was no statistical difference between HAL and orthokeratology lenses in AL elongation(P=0.157). In the low myopia group, HAL(0.05±0.12mm) and orthokeratology(0.09±0.15mm) lenses both significantly slowed AL elongation compared to SV lenses (0.27±0.17mm, P<0.001), with HAL lenses showing a slight advantage over orthokeratology lenses(P=0.038). In the moderate myopia group, both HAL(0.07±0.09mm) and orthokeratology(0±0.10mm) lenses significantly delayed AL elongation compared to SV lenses(0.22±0.14mm), with orthokeratology lenses having a stronger effect than HAL lenses(P<0.001).</p><p><strong>Conclusions: </strong>HAL lenses demonstrate superior efficacy to SV lenses in mitigating myopia progression in both low and moderate myopia. Both HAL and orthokeratology lenses are effective in reducing AL elongation. Specifically, HAL lenses exhibit greater effectiveness in decreasing AL elongation in cases of low myopia, whereas Ortho-K lenses show a pronounced advantage in managing AL elongation in moderate myopia.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104733"},"PeriodicalIF":2.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and empirical analysis of electrodesiccation combined with photodynamic therapy in the treatment of high-risk basal cell carcinoma.","authors":"Xiaojie Liu, Junru Liu, Lyuye Liu, Jipeng Yu, Dejing Gao, Tianyuan Zhou, Weibin Xing","doi":"10.1016/j.pdpdt.2025.104730","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104730","url":null,"abstract":"<p><strong>Background: </strong>Basal cell carcinoma (BCC) is the most common non-pigmented cutaneous malignancy.ALA-PDT has significant advantages in the treatment of BCC, but it is limited by the size and depth of the tumor. Combination therapy can improve the efficacy of PDT in treating BCC and overcome its limitations.</p><p><strong>Methods: </strong>A retrospective study was conducted to analyze the feasibility of ET combined with ALA-PDT in the treatment of high-risk BCC in terms of efficacy, aesthetic outcome, patient satisfaction, quality of life, and adverse reactions.</p><p><strong>Results: </strong>High-risk BCC treated with ET combined with ALA-PDT showed a cure rate of 98.55% and a recurrence rate of 1.45% at 1 year or more (average follow-up of 31 months). The treatment showed excellent aesthetic results (scar score of 1.87) and high patient satisfaction (8.03). The quality of life of the treated patients significantly improved compared to the pre-treatment period (DLQI of 13.03 and 1.94 points), and the difference was statistically significant. The average healing time was 16.81 days after treatment. The main adverse reactions were moderate pain (4.90 points) and local redness and swelling, and no infection was observed.</p><p><strong>Conclusion: </strong>ET combined with PDT showed remarkable efficacy in the treatment of high-risk BCC. The combination provides rapid healing, less scarring, and good aesthetic outcomes, which can be used as a clinical choice for treating high-risk BCC. However, it still needs to be verified in studies with larger sample sizes and longer follow-up periods.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104730"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}