Photodiagnosis and photodynamic therapy最新文献

{"title":"Changes of Refraction and Visual Quality after Ray-tracing Guided FS-LASIK in Chinese High Myopia versus Low-to-Moderate Myopia.","authors":"Yuyan Huang, Jiayu Li, Fengju Zhang, Yanzheng Song, Yushan Xu, Yixin Zhang, Yuxin Yang, Linlu Zhang, Jie Wen","doi":"10.1016/j.pdpdt.2025.105216","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105216","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the changes of refraction and visual quality after ray-tracing guided femtosecond laser-assisted in situ keratomileusis (FS-LASIK) in Chinese high myopia compared to that of low-to-moderate myopia.</p><p><strong>Methods: </strong>38 eyes in the high myopia (HM) group and 34 eyes in the low-to-moderate myopia (LM) group were evaluated 6 months after ray-tracing guided FS-LASIK. The InnovEyes Sightmap device was used to acquire high-order aberrations and generate individualized 3D eye model ablation profile. The Quality of Vision and Ocular Surface Disease Index questionnaires were used to evaluate the subjective visual quality and dry eye syndrome, respectively.</p><p><strong>Results: </strong>In the HM group, postoperative MRSE demonstrated an alternation from 0.19 ± 0.53 D at 1 month to 0.06 ± 0.35 D at 6 months (P = 0.029). Similar tendency of MRSE was observed in the LM, changing from 0.23 ± 0.33 D to 0.04 ± 0.32 D (P < 0.001). Visual symptoms gradually alleviated with time, especially the frequency and the severity of blurred vision (P = 0.007 and 0.018). None of the participants reported the bothersome of halos 6 months postoperatively. 80.95% of participants reported no dry eye discomfort 6 months after surgery. No correlations were found between preoperative MRSE and the postoperative subjective visual symptoms (all P > 0.05). Greater spherical aberration (SA) decrease at 6-mm pupil size was correlated to lower level of starburst (coef = 2.40, P = 0.046).</p><p><strong>Conclusions: </strong>Ray-tracing guided FS-LASIK demonstrated comparable efficacy and visual quality in high myopia compared to low-to-moderate myopia. The decline in SA may contributed to the relief of subjective visual complaints, especially the starbursts in high myopia.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105216"},"PeriodicalIF":2.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripapillary OCTA Metrics in Diabetic Retinopathy Patients With Varying Bevacizumab Exposure: A Cross-Sectional Study.","authors":"Farideh Mousavi, Salar Nikmanesh, Amin Arasteh, Amir Tarkavani, Amir Eftekhari Milani, Peyman Ghodraty","doi":"10.1016/j.pdpdt.2025.105217","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105217","url":null,"abstract":"<p><strong>Objective: </strong>To compare optic nerve head (ONH) microvasculature and retinal nerve fiber layer (RNFL) thickness of diabetic retinopathy (DR) patients with varying numbers of intravitreal bevacizumab (IVB) injections to non-diabetic controls via optical coherence tomography angiography (OCTA).</p><p><strong>Methods: </strong>It is a cross-sectional study of 246 eyes of 145 patients in 4 groups: group A: healthy control subjects (53 eyes); group B: DR without any IVB treatment (103 eyes); group C: DR one week after their first IVB injection (42 eyes); and group D: DR which received at least 9 IVB injections for the past year (48 eyes). All the included eyes underwent ONH OCTA using the AngioVue system, and the peripapillary vessel density (VD) and RNFL thickness were evaluated.</p><p><strong>Results: </strong>60 males and 85 females with a median age of 64.0 years were included in the study. The groups were not different in terms of age or sex. Groups C and D presented significantly lower peripapillary VDs than the controls (49.6% and 48.9% vs. 53.0%, respectively, p<0.001). The peripapillary VD was lower in treatment-naïve DR cases than in controls, but this difference was not statistically significant (51.4% vs. 53.0%). The whole-image VD was lower in group B than in group A (47.8% vs. 49.6%, p=0.007); however, when the comparison was limited to mild to moderate DRs, the difference was insignificant (p=0.949). Although the peripapillary VD was lower in group D cases than in group B cases (48.9% vs. 51.4%, p=0.020), the subgroup analysis of severe NPDR patients in groups B, C, and D revealed no significant differences among the three groups in terms of peripapillary VD. However, the nasal segment VD was significantly lower in IVB-treated cases than in treatment-naïve cases. In addition, among treatment-naïve cases, the PDR cases had lower nasal VD than the mild NPDR cases. The RNFL thickness was not significantly different among the four groups (p=0.256).</p><p><strong>Conclusion: </strong>Diabetic retinopathy and anti-VEGF treatment could reduce the peripapillary VD, which seems to happen primarily in the nasal segment and becomes evident in more advanced stages of DR. However, the frequency of IVB injections might not affect the peripapillary microvasculature.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105217"},"PeriodicalIF":2.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Evaluation of topical photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA) for cervical intraepithelial neoplasia with human papillomavirus (HPV) infection: a retrospective comparative study versus loop electrosurgical excision procedure (LEEP)\" [Photodiagnosis Photodyn Ther. (2025);54:104697].","authors":"Jue Li, Ying Huang, Jinxin Tao, Hangli Yang, Hua Zhu","doi":"10.1016/j.pdpdt.2025.104764","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104764","url":null,"abstract":"","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104764"},"PeriodicalIF":2.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoinactivation of Planktonic Cutibacterium acnes subsp. elongatum: A Study on Wavelength-Dependent Effects.","authors":"Robin Haag, Moritz Mack, Oksana Gurow, Rukia Schablout, Alexander Oberderfer, Jörg Moisel, Martin Hessling","doi":"10.1016/j.pdpdt.2025.105213","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105213","url":null,"abstract":"<p><p>Bacterial inflammatory skin conditions, especially those caused by Cutibacterium acnes (C. acnes), are among the most common skin diseases globally. While C. acnes is a gram-positive bacterium found in healthy human skin, its overgrowth or reduced phylotype diversity have been associated with inflammatory conditions such as acne vulgaris. Traditional treatments often apply antibiotics. Alternatives, like photodynamic therapy (PDT) and intense pulsed light (IPL) therapy, apply visible light irradiation. These therapies utilize photosensitizers, such as coproporphyrin III (CP III), to generate reactive oxygen species (ROS) under specific wavelengths that inactivate bacteria. Compounds like aminolevulinic acid (ALA) enhance therapeutic effectiveness. In this study planktonic cultures of C. acnes subsp. elongatum were irradiated at wavelengths matched to the CP III absorbance spectrum, including rarely applied green and yellow light: 405 nm (violet), 496 nm (cyan), 547 nm (lime), 594 nm (yellow/amber), and 636 nm (red). To target flavins, another group of photosensitizers, C. acnes was irradiated at 456 nm (blue), resulting in bacterial reductions comparable to violet light. Results revealed a lethal dose to inactivate 90% (LD90) of 83.3 J/cm² at 405 nm. Higher doses were required for longer wavelengths with lower CP III absorbance. The addition of ALA improved the 636 nm LD90 dose from 2666 J/cm² to 1369 J/cm². This efficacy was comparable to green or yellow irradiation. These findings suggest that certain wavelengths, even without additives, may offer a competitive and simpler therapeutic option for irradiation therapies. Convolution of the applied LED spectra with the CP III absorbance spectra indicates a mathematical relationship between applied wavelength and bacterial reduction.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105213"},"PeriodicalIF":2.6,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzymatic and mechanical disruption before successive photodynamic therapy targets the extracellular matrix of Candida albicans.","authors":"Amanda Bellini, Luana Mendonça Dias, César Augusto Abreu-Pereira, Ana Luíza Gorayb-Pereira, Marlise Inêz Klein, Ana Cláudia Pavarina","doi":"10.1016/j.pdpdt.2025.105214","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105214","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether pretreatment strategies targeting the extracellular matrix (ECM), such as DNase I and low-frequency ultrasound, enhance the efficacy of successive antimicrobial photodynamic therapy (aPDT) against Candida albicans biofilms and to assess the effects on biofilm components.</p><p><strong>Methods: </strong>Forty-eight-hour C. albicans (ATCC 90028) biofilms were treated under four conditions: (I) aPDT [Photodithazine (PDZ) (25 mg/L) for 20 min + Light-Emitting Diode (LED) (660 nm, 18 J/cm²)], (II) DNase+aPDT [5 min with 20 U/mL DNase I before aPDT], (III) sonication+aPDT [7 W, 170-190 J before aPDT], (IV) Dn+So+aPDT. Ten successive aPDT applications were performed. Colony-forming units per milliliter (CFU/mL) was assessed after each application. After applications 1, 5, and 10, total and insoluble dry weight, soluble/insoluble proteins, water-soluble polysaccharides (WSP), alkali-soluble polysaccharides (ASP), and extracellular DNA (eDNA) were quantified. Biofilm architecture was analyzed by scanning electron microscopy (SEM).</p><p><strong>Results: </strong>All groups showed significant CFU/mL reduction after ten aPDT applications compared to untreated control: aPDT (5.7 log₁₀), Dn+aPDT (5.5 log₁₀), So+aPDT (5.3 log₁₀), Dn+So+aPDT (5.3 log₁₀) (p<0.05). Insoluble proteins decreased after the first application (46%), and soluble proteins after the fifth and tenth (45%; p≤0.032). WSP and eDNA were significantly reduced (p≤0.047). No significant differences were observed for total/insoluble dry weight, proteins, and ASP. SEM revealed wall deformities and fewer clusters.</p><p><strong>Conclusion: </strong>Successive aPDT applications reduced CFU/mL, WSP, and eDNA in C. albicans biofilms regardless of pretreatment strategy.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105214"},"PeriodicalIF":2.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic therapy using talaporfin sodium and semiconductor laser induces dose and time dependent cytocidal effect for human glioma derived stem cells.","authors":"Megumi Ichikawa, Jiro Akimoto, Srivalleesha Mallidi, Hiroaki Wakimoto, Michihiro Kohno, Tayyaba Hasan","doi":"10.1016/j.pdpdt.2025.105215","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105215","url":null,"abstract":"<p><p>One of the key factors contributing to the poor prognosis of glioblastoma is the treatment resistance of glioma stem cells (GSCs). In this study, the efficacy of photodynamic therapy (PDT) using talaporfin sodium (NPe6), a second-generation photosensitizer, in combination with a semiconductor laser approved for clinical use in Japan was evaluated. The evaluation was performed in a patient-derived glioma stem cell (GSC) line, MGG8, which was established from human glioblastoma tissue. Under favorable oxygenation conditions, NPe6-PDT induced a dose- and fluence-dependent suppression of mitochondrial metabolic activity in MGG8 cells. Both apoptosis and necrosis occurred in a time-dependent manner. Secondary reactive oxygen species (ROS) levels were also increased following PDT, indicating sustained intracellular oxidative stress. Given that GSC resistance is partly attributed to hypoxic microenvironments that diminish treatment-induced oxidative damage, these findings suggest that strategies to enhance tissue oxygenation could improve the therapeutic efficacy of NPe6-PDT against GSCs. To our knowledge, this is the first study to investigate NPe6-PDT in patient-derived GSCs and provides a foundation for future translational research.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105215"},"PeriodicalIF":2.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multi-Task Deep Learning Pipeline Integrating Vessel Segmentation and Radiomics for Multiclass Retinal Disease Classification.","authors":"Feng Yan, Yanxia Liu, Qingsong Zhao, Guangguo He","doi":"10.1016/j.pdpdt.2025.105209","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105209","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to develop a robust, multi-task deep learning framework that integrates vessel segmentation and radiomic analysis for the automated classification of four retinal conditions- diabetic retinopathy (DR), hypertensive retinopathy (HR), papilledema, and normal fundus-using fundus images.</p><p><strong>Materials: </strong>AND.</p><p><strong>Methods: </strong>A total of 2,165 patients from eight medical centers were enrolled. Fundus images underwent standardized preprocessing including histogram equalization, normalization, resizing, and augmentation. Whole vessel and artery-vein segmentations were conducted using five deep learning models: U-Net, Attention U-Net, DeepLabV3+, HRNet, and Swin-Unet. From the segmented vascular maps, 220 radiomic features were extracted using PyRadiomics and Mahotas toolkits. The arteriovenous ratio (AVR) was also computed from artery and vein masks. ICC analysis was used to assess reproducibility across centers, with features below ICC < 0.75 excluded. Feature selection was performed using Least Absolute Shrinkage and Selection Operator (LASSO), Recursive Feature Elimination (RFE), and Mutual Information (MI). The combined AVR and radiomic features were input into four classifiers- Extreme Gradient Boosting (XGBoost), Categorical Boosting (CatBoost), Random Forest (RF), and Ensemble. Models were trained and validated on stratified splits and externally tested on an independent cohort of 769 patients. Evaluation metrics included accuracy, area under curve (AUC), recall, and receiver operating characteristics (ROC) analysis.</p><p><strong>Results: </strong>Swin-Unet outperformed all models with external Dice Similarity Coefficient (DSC) of 92.4% for whole vessel and 89.8% for artery-vein segmentation. Classification using the LASSO-Ensemble combination achieved test accuracy of 93.7%, external test accuracy of 92.3%, and AUC of 95.2%. AVR estimates were consistent with clinical expectations and contributed significantly to class discrimination.</p><p><strong>Conclusion: </strong>This multi-task pipeline demonstrates the potential of combining transformer-based segmentation with radiomics for accurate, interpretable retinal disease classification, showing strong generalizability for future clinical applications.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105209"},"PeriodicalIF":2.6,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining Scar Quality: A Synergistic Approach with Micro-needling and Photodynamic Therapy using Methylene Blue as a Photosensitizer: A Randomized Clinical Trial.","authors":"Mahshid Sabetghadam, Behzad Imani, Amir Derakhshan Far, Fatemeh Shahbazi, Zahra Farahani Nik","doi":"10.1016/j.pdpdt.2025.104787","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104787","url":null,"abstract":"<p><strong>Background: </strong>Hypertrophic and keloid scars are challenging to treat and can cause both aesthetic and functional problems. Traditional treatments such as laser therapy and corticosteroids have limited effectiveness and high recurrence rates. However, the emergence of photodynamic therapy (PDT) combined with micro-needling, especially when using methylene blue as a photosensitizer (PS) at different concentrations, offers a promising approach for scar treatment.</p><p><strong>Objective: </strong>This study evaluates the effectiveness of combining PDT, micro-needling, and methylene blue at 1% and 0.1% concentrations to improve the quality of hypertrophic and keloid scars.</p><p><strong>Methods: </strong>Novel Study Design: a randomized, double-blind clinical trial was conducted on 37 patients with 94 hypertrophic and keloid scars. Patients were divided into four groups based on scar type and methylene blue concentration. Each group underwent five treatment sessions, and scars were assessed using the Japan Scar Scale (JSS) and the Patient and Observer Scar Assessment Scale (POSAS).</p><p><strong>Results: </strong>Significant Improvements: after five treatment sessions, we observed substantial improvements in various scar parameters. The Evaluation part of Japan Scar Scale (JSS) scores decreased from an average of 14.69 ± 2.81 at baseline to 4.69 ± 0.92 after six months, indicating a significant reduction in scar severity. The patient-observer scar assessment scale results show a notable improvement in Flexibility and thickness, with a 71% reduction in stiffness and a 69% reduction in pain. Overall, patient satisfaction increased by 60%, and visible improvements in pigmentation and vascularity were reported. The use of 1% methylene blue led to better outcomes than 0.1%, possibly due to enhanced light penetration and reactive oxygen species (ROS) generation. Importantly, no severe side effects were observed, and patient compliance remained high throughout the study.</p><p><strong>Conclusion: </strong>Combining PDT and micro-needling using 1% methylene blue improves scar quality and prevents it from worsening, particularly for keloid scars. Further studies are recommended to confirm these findings and explore long-term effects.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104787"},"PeriodicalIF":2.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Er Cr: YSGG laser, ytterbium fiber laser, and Rose Bengal-activated low-level laser therapy on roughness and shear bond strength of yttria-stabilized zirconia.","authors":"Ghadeer Islem Basunbul","doi":"10.1016/j.pdpdt.2025.104784","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104784","url":null,"abstract":"<p><strong>Aim: </strong>Effect of Er Cr: YSGG laser (ECL), ytterbium fiber laser (YFL), Rose Bengal (RB) activated low-level laser therapy (LLLT) on the surface roughness (Ra) and shear bond strength (SBS) of yttrium-stabilized tetragonal zirconia polycrystal (Y-TZP) bonded to resin cement.</p><p><strong>Materials and methods: </strong>Sixty-four 3Y-TZP discs were prepared, and subsequently, categorized into four distinct groups based on the conditioning regimen (n=16): Group 1 (SB), Group 2 (ECL), Group 3 (YFL), and Group 4 (LLLT-RB). The Ra assessment was performed on five samples from each group using a profilometer. One specimen from each group was subjected to surface topography analysis under a scanning electron microscope (SEM). A self-adhesive resin cement was built on ten samples from each group and photo polymerized, followed by artificial ageing. The SBS and failure modes were assessed using a universal testing machine and a stereomicroscope, respectively. The data was evaluated using ANOVA and a post hoc test, p = 0.05.</p><p><strong>Results: </strong>Samples surface treated with YFL attained the highest Ra scores (1334.32 ± 0.065 µm) and highest bond strength (9.34±0.29 MPa). In contrast, the 3Y-TZP discs surface treated with LLLT-RB exhibited the lowest Ra value (870.56 ± 0.076 µm) and the lowest bond values (5.76±0.34 MPa). Zirconia disc surface treated with ECL and SB groups demonstrated admixed failures. LLLT (RB), on the other hand, exhibited adhesive fractures with the highest frequency.</p><p><strong>Conclusion: </strong>Ytterbium fiber laser displayed the most satisfactory performance in terms of improving surface roughness and shear bond strength of zirconia with the resin cement, and can be used as an alternative surface pretreating regime for zirconia.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104784"},"PeriodicalIF":2.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Two Different Types of Daily Disposable Monofocal Contact Lenses on Ocular Wavefront Aberrations: (Impact of Daily Disposable Contact Lenses on Ocular Wavefront Aberrations).","authors":"Konuralp Yakar","doi":"10.1016/j.pdpdt.2025.104780","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104780","url":null,"abstract":"<p><strong>Background: </strong>To compare the effect of two daily disposable soft contact lenses on ocular wavefront aberrations.</p><p><strong>Methods: </strong>This study included 34 eyes from 17 patients aged 18 to 40 years (mean age: 27.12±8.3 years) with identical myopic refractive errors in both eyes without astigmatism and requesting contact lens use. Initially, wavefront aberrations; total, tilt, high, total coma, total trefoil, total 4.foil, sphere, high astigmatism, RMS (3mm/5mm) were measured using Nidek OPD Scan II aberrometer/topograph in both eyes without contact lenses. Acuvue Oasys with HydraLuxe 1-Day (senofilcon A) daily disposable contact lenses were applied to the right eye, while Precision 1 (verofilcon A) daily disposable contact lenses were applied to the left eye based on refractive errors. Wavefront aberration measurements were repeated 60 min later with contact lenses, and aberrations were compared to baseline and fellow eyes' measurements. The magnitudes of aberration changes after contact lens application were analyzed.</p><p><strong>Results: </strong>Both types of daily disposable contact lenses reduced total wavefront aberrations. Acuvue Oasys with HydraLuxe 1-Day contact lenses showed a significant increase in total trefoil aberration (p=0.048). Precision 1 contact lenses showed a significant increase (p=0.034) only in total tilt aberrations compared to baseline. No significant differences were found between the lenses regarding changes in all wavefront aberrations.</p><p><strong>Conclusion: </strong>Both daily disposable lenses effectively reduced total wavefront aberrations, though they increased certain subtypes of high-order aberrations in young adult myopes.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104780"},"PeriodicalIF":2.6,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}