Photodiagnosis and photodynamic therapy最新文献

{"title":"Corneal epithelial remodeling following myopic ray-tracing-guided laser-assisted in situ keratomileusis: a clinical study.","authors":"Lei Luo, Yimeng Fan, Xindi Wang, Linjuan Yang, Shimin Tan, Yu Zhang, Qianrong Hu, Yan Cai, Jingni Yu, Zhao Liu, Qianyan Kang, Shengjian Mi","doi":"10.1016/j.pdpdt.2025.105257","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105257","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate corneal epithelial remodeling profile following ray-tracing-guided laser-assisted in situ keratomileusis (LASIK) for myopia.</p><p><strong>Methods: </strong>This retrospective study enrolled 65 eyes from 33 patients undergoing ray-tracing-guided LASIK for myopia. Corneal epithelial thickness (CET) was measured across a 9-mm diameter area using RTVue XR OCT preoperatively and at 1, 3 and 6 months postoperatively. CET was analyzed by concentric zones and sections.</p><p><strong>Results: </strong>Regionally, at 6 months, CET significantly increased in central (+4.28 μm, 7.8%), paracentral (+8.11 μm, 15.0%), midperiphery zones (+1.83 μm, 3.4%) (all P < 0.05) and unchanged in periphery zone (P = 1.000), with the most pronounced thickening in paracentral temporal and inferotemporal sections. Longitudinally, at 1 month, CET stabilized centrally (P = 1.000), significantly thickened paracentrally and thinned peripherally (both P < 0.05). From 1 to 3 months, central and paracentral zones significantly thickened (both P < 0.001). From 3 to 6 months, all zones stabilized (all P > 0.05). Notably, despite epithelial changes, neither significant regression nor increase of spherical aberration were observed at 6 months (both P > 0.05). Positive correlations were observed between changes in CET and both the amount of refractive error to be corrected and the ablation depth across all zones (all P < 0.05).</p><p><strong>Conclusions: </strong>Ray-tracing-guided LASIK induced regionally and longitudinally non-uniform corneal epithelial remodeling. Despite corneal epithelial thickness increase, the visual and refractive outcomes were favorable and stable after the surgery.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105257"},"PeriodicalIF":2.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OCT-Based Retinal Parameters and Choroidal Vascular Indices Predicting Response to Anti-TNF-α Therapy in Inflammatory Bowel Disease.","authors":"Fenying Lu, Yuechen Du, Yijie Gu, Yujie Jiao, Yue Gu, Jingjing Yu, Yimin Xia, Danqing Shen","doi":"10.1016/j.pdpdt.2025.105254","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105254","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to quantitatively analyze retinal structural parameters and choroidal vascular indices using optical coherence tomography (OCT) technology, in order to evaluate the predictive value of these ocular biomarkers for the progression to retinopathy in patients with inflammatory bowel disease (IBD), and to analyze the predictive efficacy of changes in OCT parameters for the treatment response to TNF-α inhibitor therapy in IBD patients.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 180 IBD patients treated between January 2022 and December 2023 [including 75 patients with Crohn's disease (41.67%) and 105 patients with ulcerative colitis (58.33%)]. Patients were divided into groups based on disease progression characteristics. The progression group consisted of IBD patients who developed newly detected retinopathy during follow-up (n=64), while the stable group included those without retinopathy and with maintained intestinal disease stability (n=116). All patients underwent OCT examination. Retinal parameters-including retinal nerve fiber layer (RNFL), ganglion cell inner-plexiform layer (GCIPL), and central macular thickness (CMT)-as well as choroidal vascular indices-such as choroidal vascularity index (CVI), choroidal capillary vascular density (CC-VD) and choroidal thickness in the macular central sulcus (SF-CT)] were compared between the two groups. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive performance of these parameters for diseases outcomes in IBD patients. Nomograms and calibration curves were constructed to develop a prediction model for IBD progression. Patients in the progression group received TNF-α inhibitor (adalimumab) therapy. ROC analysis was conducted to assess the predictive efficacy of retinal parameters and choroidal vascular indexes for the response to biologic therapy.</p><p><strong>Results: </strong>The area under the curve (AUC) values for predicting disease outcomes in IBD patients were 0.907 for RNFL, 0.939 for GCIPL, and 0.871 for CMT. The AUC values for CVI, CC-VD, and SF-CT in predicting disease outcomes were 0.918, 0.965 and 0.946, respectively. The nomogram indication models constructed using retinal parameters and choroidal vascular indicators demonstrated high accuracy. Moreover, GCIPL, CVI and CC-VD showed high predictive value for the response to biologic therapy in the progression group, with AUC values of 0.952, 0.941, and 0.993, respectively.</p><p><strong>Conclusion: </strong>Retinal parameters and choroidal vascular indexes based on OCT technology can effectively predict disease outcomes in patients with IBD and provide valuable guidance for evaluating the response to biologic therapy.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105254"},"PeriodicalIF":2.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response on the comment: Comment on \"Infrared spectroscopy for fast screening of diabetes and periodontitis\" authored by Ivan Bratchenko and Lyudmila Bracthenko.","authors":"Marcelo Saito Nogueira, Luis Felipe das Chagas E Silva de Carvalho","doi":"10.1016/j.pdpdt.2025.105252","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105252","url":null,"abstract":"","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105252"},"PeriodicalIF":2.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Bendazol Eye Drop Atomization in Slowing Myopia Progression in Children: A Randomized, Double-Blind, Placebo-Controlled Trial.","authors":"Airui Xie, Haobo Fan, Aiming Jiang, Juan Wen, Meiqin Shi, Jianbin Ye, Zhilin Li, Junguo Duan","doi":"10.1016/j.pdpdt.2025.105253","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105253","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the efficacy and safety of bendazol eye drop atomization in controlling the progression of myopia in children through a randomized, double-blind, placebo-controlled clinical trial.</p><p><strong>Methods: </strong>From May 2022 to August 2023, children aged 8 to 12 years with myopia were recruited from the outpatient clinic at Ineye Hospital, Chengdu University of Traditional Chinese Medicine. Participants were randomly assigned to either the intervention group or the control group. All participants wore standard monofocal spectacles. The intervention group received ultrasonic atomization of bendazol eye drops for 10 minutes daily, while the control group received atomization of a placebo solution (identical in appearance but without bendazol) following the same protocol. The intervention period lasted for 24 weeks.</p><p><strong>Results: </strong>When compared with the placebo group, the intervention group demonstrated a significantly slower increase in spherical equivalent at both 12 and 24 weeks, in addition to a significantly smaller increase in axial length at 24 weeks (all p < 0.05)..The tear film break-up time significantly increased post-intervention compared to baseline values in both groups (p < 0.05).</p><p><strong>Conclusions: </strong>Bendazol eye drop atomization effectively delayed the progression of myopia in children, as evidenced by inhibition of spherical equivalent progression and axial elongation. The treatment improved tear film stability without affecting pupil diameter and demonstrated a favorable safety profile for clinical use.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105253"},"PeriodicalIF":2.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel OCTA-Based Image Processing Method for Enhanced Microaneurysm Detection and 3D Visualization in Diabetic Retinopathy.","authors":"Nianjia Wang, Xindi Liu, Jiayi Wu, Xintong Xiang, Yujia Gao, Liang Yao","doi":"10.1016/j.pdpdt.2025.105258","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105258","url":null,"abstract":"<p><p>The early detection of microaneurysms (MA) in diabetic retinopathy (DR) is crucial for disease management. Although optical coherence tomography angiography (OCTA) offers non-invasive, high-resolution imags, it still suffers from insufficient sensitivity and limitations of two-dimensional imaging in MA's detection. This study proposes an innovative processing method based on retinal OCTA images that integrates blood flow signals with the hyperreflective features of MA in structural OCT, combined with three-dimensional reconstruction technology, to construct a retinal vascular image (3D-MA map) that enhances MA's detection rate and provides 3D visualization. Using the open-source software ImageJ, this method enables visual analysis of the spatial morphology and arteriovenous origin of MAs. The results show that the 3D-MA image preserves three-dimensional stereoscopic effects while enhancing the display of vascular abnormalities, particularly improving the recognition of MAs that are challenging to detect with OCTA alone. This study provides a powerful imaging tool for early diagnosis and mechanistic research of diabetic retinopathy.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105258"},"PeriodicalIF":2.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the efficacy of carbon dioxide laser combined with 5-aminolevulinic acid photodynamic therapy in treating high-grade vaginal squamous intraepithelial lesions following hysterectomy.","authors":"Bingying Sun, Yi Chen, Dan Cao, Ying Xu, Dan Wu","doi":"10.1016/j.pdpdt.2025.105256","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105256","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical efficacy and safety of carbon dioxide (CO₂) laser combined with 5-aminolevulinic acid (ALA)-photodynamic therapy (PDT) for treating high-grade vaginal squamous intraepithelial lesions (VaIN) following hysterectomy for cervical cancer or precancerous lesions.</p><p><strong>Methods: </strong>We retrospectively analyzed medical records of 120 women who developed high-grade VaIN after hysterectomy for cervical cancer or high-grade squamous intraepithelial lesions (HSILs). Forty patients received CO₂ laser once (laser group), 40 received PDT six times (PDT group), and 40 received CO₂ laser once and PDT three times (laser +PDT group).</p><p><strong>Results: </strong>At the 3-6-month follow-up, the cure rate (clearance rate of lesions along with HPV) in the laser +PDT group was higher than that in the laser (72.50% vs. 42.50%, P=0.007) and PDT groups (72.50% vs. 47.50%, P=0.022). The HPV clearance rate in the laser +PDT group was higher than that in the laser (75.00% vs. 45.00%, P=0.006) and PDT groups (75.00% vs. 52.50%, P=0.036). In the PDT group, a patient with pathological upgrading received partial vaginectomy. At the 9-12-month follow-up, recurrence and incidence rate of VaIN in the laser +PDT group were lower than those in the laser (12.50% vs. 37.04%, P=0.027) and PDT groups (12.50% vs. 34.78%, P=0.048). No vaginal adhesion or scar formation was observed in the PDT group.</p><p><strong>Conclusions: </strong>The efficacy of CO₂ laser combined with PDT in treating high-grade vaginal intraepithelial neoplasia after hysterectomy for cervical cancer or cervical HSIL was confirmed in terms of lesion remission and HPV clearance rates. Combination treatments can reduce recurrence rates.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105256"},"PeriodicalIF":2.6,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the efficacy of topical photodynamic therapy against cervical HPV infection.","authors":"Xiaoyun Wang, Yiquan Chen, Xiaoming Xu, Jianxia Huang, Qiong He, Zheng Huang, Jianwei Zhou","doi":"10.1016/j.pdpdt.2025.105250","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105250","url":null,"abstract":"<p><strong>Background: </strong>Persistent high-risk HPV (hr-HPV) infection is a leading cause of cervical cancer. Currently, there are no specific treatment available that can eradicate the HPV virus. Studies demonstrate that photodynamic therapy (PDT) mediated by 5-aminolevulinic acid (ALA) is highly effective for treating precancerous lesions and HPV infection of the cervix and vagina.</p><p><strong>Aims: </strong>To evaluate the efficacy of ALA PDT for patients with hr-HPV infections but without precancerous cervical lesions.</p><p><strong>Methods: </strong>Thirty-one patients with persistent hr-HPV infection for over one year were treated with topical ALA PDT. HPV tests, cytological examinations or colposcopy-guided biopsies were performed before and after treatment. Symptoms and adverse reactions related to PDT were also evaluated.</p><p><strong>Results: </strong>Six-month follow-up showed that the effective rate in treating simple HPV infection was >70%. Subgroup analysis demonstrated that the presence of vaginitis, absence of significant cervical pathological changes, Type III transformation zone, and a prior history of cervical surgery were all significantly associated with persistent HPV positivity after PDT (p < 0.05). Further multivariate analysis confirmed that vaginitis and the lack of mucosal abnormalities in cervical pathology independently predicted persistent HPV positivity after PDT. In HPV-related koilocytic atypia, Ki-67 expression extended beyond the normal proliferative zone, with positive nuclei throughout the epithelium. This may indicate a mechanism for improved HPV clearance after PDT. No severe adverse events occurred during the treatment. Post-treatment evaluation revealed no structural damage or invasive alterations to the cervix.</p><p><strong>Conclusions: </strong>ALA-PDT is a highly effective and safe non-invasive field-directed treatment option for patients with hr-HPV infection.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105250"},"PeriodicalIF":2.6,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A meta-analysis of the efficacy and safety of indocyanine green fluorescence imaging-guided laparoscopic cholecystectomy.","authors":"Jinquan Tang, Tao Wu, Liu Yang, Yong Pan, Zhirui Zou, Xiaohong Zhang","doi":"10.1016/j.pdpdt.2025.105245","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105245","url":null,"abstract":"<p><strong>Objective: </strong>To systematically evaluate the efficacy and safety of indocyanine green fluorescence imaging-guided laparoscopic cholecystectomy (FI-LC).</p><p><strong>Methods: </strong>A comprehensive search of Web of Science, PubMed, Embase, and the Cochrane Library was conducted to identify randomized controlled trials and cohort studies comparing FI-LC with conventional laparoscopic cholecystectomy (C-LC), published from database inception to June 2025. Eligible studies were assessed for quality, and a meta-analysis was performed using Stata 12.</p><p><strong>Results: </strong>Twenty-six studies involving 4,436 patients were included. Compared with C-LC, FI-LC significantly reduced operative time (weighted mean difference, WMD = -12.11, 95% CI: -19.63 to -4.60, P = 0.002) and biliary structure identification time (WMD = -4.39, 95% CI: -6.75 to -2.03, P < 0.001), had a higher success rate in identification of cystic duct (odds ratio, OR = 3.76, 95% CI: 2.66 to 5.33, P < 0.001) and identification of common bile duct (odds ratio, OR = 2.94, 95% CI: 2.31 to 3.74, P < 0.001), lowered the conversion to open surgery rate (OR = 0.22, 95% CI: 0.13 to 0.39, P < 0.001), and shortened hospital stay (WMD = -0.60, 95% CI: -0.82 to -0.38, P < 0.001). However, no statistically significant differences were found between the two groups in intraoperative blood loss, bile duct injury rates, or postoperative complications.</p><p><strong>Conclusion: </strong>Fluorescence imaging enhances surgical efficiency, reduces the risk of conversion to open surgery, and shortens hospital stay. Its safety and efficacy are superior to those of C-LC, especially in cases with complex Calot's triangle anatomy.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105245"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of a novel ultrasound biomicroscope for measuring corneal epithelial thickness and agreement with an SD-OCT based device.","authors":"Yiran Wang, Ting Wan, Qinghao Meng, Rui Ning, Xinning Yang, Shenrong Zhang, Giacomo Savini, Domenico Schiano-Lomoriello, Jinhai Huang, Shihao Chen","doi":"10.1016/j.pdpdt.2025.105246","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105246","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the accuracy of corneal epithelial thickness (ET) measurements in healthy and post transepithelial photorefractive keratectomy (post-T-PRK) eyes using a novel ultrasound biomicroscope (Insight 100, ArcScan, Colorado, USA) and to compare the agreement with the measurements provided by a spectral-domain optical coherence tomographer (RTVue-XR, Optovue, Fremont, CA).</p><p><strong>Methods: </strong>In total, 32 healthy and 38 post-T-PRK eyes were included. Three consecutive measurements of right eye were acquired with the Insight 100 VHF-UBM and RTVue-XR SD-OCT. Accuracy was analyzed using intraclass correlation coefficient (ICC), test-retest repeatability (TRT), within-subject coefficient of variation (CoV), and within-subject standard deviation (S_w). Agreement was assessed by Bland-Altman analysis and paired t-tests.</p><p><strong>Results: </strong>The precision of the normal eyes were higher than post-T-PRK eyes. Central epithelial thickness (CET) had the best repeatability and reproducibility, CoV was 0.5%∼1.71%. The S_w and TRT was 0.35µm and 0.79µm in normal eyes, 1.02µm and 1.92µm in post-T-PRK eyes. ET_superior-6mm has poor repeatability in normal eyes. However, post-T-PRK eyes have the worst repeatability at ET _inferior-3mm and ET _temporal-3mm. Agreement of CET was excellent in both groups. The widest 95% LoA range appeared at ET_superior-6mm of normal and post-T-PRK eyes, with 0.72∼8.74µm and -9.51∼7.32µm, respectively.</p><p><strong>Conclusion: </strong>The Insight 100 provides good repeatability and reproducibility for ET measurements in normal and post-T-PRK eyes. CET can be used interchangeably between Insight 100 and RTVue-XR, however, it is not recommended for other positions.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105246"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of topical photodynamic therapy with 5-aminolevulinic acid in the treatment of high-risk cervical low-grade squamous intraepithelial lesions.","authors":"Shuyu Yuan, Mengzhuo Zhang, Chunyan Zhang, Yuehui Su, Kaili Dai, Yimeng Wang, Yiduo Yu, Lijuan Zhang, Lili Cao, Ting Zhang, Mengzhen Zhang","doi":"10.1016/j.pdpdt.2025.105248","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.105248","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the clinical efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of high-risk cervical low-grade squamous intraepithelial lesion (LSIL) and to analyze the influence of different risk factors on the efficacy.</p><p><strong>Methods: </strong>The clinical data of 173 patients with persistent cervical LSIL and high-risk human papillomavirus (HR-HPV) infection were retrospectively analyzed. After treatment, HPV and TCT were reexamined every 3 months, and colposcopic biopsy was performed if necessary.</p><p><strong>Results: </strong>At 6 months of follow-up, the HPV clearance rate, complete remission (CR) rate, persistence rate, and progression rate were 73.41%, 89.60%, 8.09%, and 2.31%, respectively. The HPV clearance rate showed an upward trend with time. Moreover, the CR rates of patients with 41-50 years old group, positive HPV16/18 genotyping, and type 3 transformation zone (TZ) were 77.14%, 84.52%, and 83.33%, respectively; these rates were significantly lower compared to patients without the corresponding high-risk factors (P=0.021, 0.045, 0.042), but had no significant effect on HPV clearance rate. A subgroup analysis based on TCT results revealed no significant effect on the efficacy of ALA-PDT in the treatment of high-risk cervical LSIL. Furthermore, the 6-month CR rate and 2-year HPV clearance rate of the patients with both positive HPV16/18 genotyping and TZ3 were significantly lower than those of the patients without the two high-risk factors (73.53% vs. 94.74%, P=0.010; 78.95% vs. 97.67%, P=0.028, respectively).</p><p><strong>Conclusion: </strong>ALA-PDT is a safe and effective treatment for high-risk cervical LSIL. Its efficacy could be affected by patient age, HPV type, and cervical TZ type.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105248"},"PeriodicalIF":2.6,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}