Photodiagnosis and photodynamic therapy最新文献

{"title":"Pitfalls and Other Issues with the MTT Assay.","authors":"David Kessel","doi":"10.1016/j.pdpdt.2025.104700","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104700","url":null,"abstract":"<p><p>While the colorimetric assay commonly referred to as 'MTT' does provide an indication of effects of photodamage on mitochondrial enzyme levels, a careful analysis showed that the resulting data were not correlated with a clonogenic assay. While MTT data can be claimed to represent 'cytotoxicity', this is an undefined term and appears not to be necessarily correlated with the object of anti-tumor therapy: tumor eradication. Use of this assay for assessing effects of treatment on viability are therefore unreliable.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104700"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of C-33A cervical carcinoma spheroids on Japanese quail CAM: relevance in assessment of photodiagnosis and photodynamic therapy mediated by hypericin.","authors":"Mariana Máčajová, Veronika Huntošová, Barbora Kundeková, Majlinda Meta, Ivan Čavarga, Boris Bilčík","doi":"10.1016/j.pdpdt.2025.104699","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104699","url":null,"abstract":"<p><p>Cervical cancer is the most common type of cancer in women. The present study aims to establish a reliable model of human cervical cancer microtumours (C-33A) growing on the chorioallantoic membrane (CAM) of quail embryos to test the efficacy of anticancer drugs. Cultrex®, an extracellular matrix, was used as a scaffold for C-33A spheroids. Hypericin, a natural perylene quinone, was used in this study as a model photosensitizer for photodiagnosis and photodynamic therapy (PDT). Fluorescence pharmacokinetics were recorded to verify the robustness of the model. The changes in vessel growth parameters were determined after weak PDT (405 nm, 2 minutes and 285 mW/cm²) with the aim to reduce vascularisation and nutrition of the C-33A spheroids. Vasoconstriction and occlusion of small vessels and capillaries were identified in the CAM. Subsequently, histological examination revealed changes in the chorioallantoic ectoderm of the CAM. An invasion of C-33A cells into the CAM was confirmed. Furthermore, increased expression of growth factor genes was detected by qPCR, indicating angiogenesis of the CAM tissue. In summary, C-33A cells in Cultrex® grown on CAM were shown as a valuable ex ovo 3D spheroid model for photodiagnosis and PDT assays of cervical cancer.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104699"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Painless PDT using 10% aminolevulinate gel and red light: A pilot clinical trial of short-contact protocols to reduce discomfort during illumination.","authors":"Jessica S Johnson, Jackson Hanna, Amy S Nowacki, Sanjay Anand, Alan S Shen, Edward V Maytin","doi":"10.1016/j.pdpdt.2025.104698","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104698","url":null,"abstract":"<p><strong>Background: </strong>Traditional red light photodynamic therapy for actinic keratoses (AK) causes significant pain during illumination.</p><p><strong>Objective: </strong>To evaluate new short-incubation red light PDT regimens for their pain and efficacy characteristics.</p><p><strong>Methods: </strong>Patients (n = 30) with facial AK were treated with 10% ALA gel (no occlusion) and red light (635 nm), after randomization as follows [incubation time, illumination time (fluence)]: Group A [10 min, 20 min (74 J/cm²)]; Group B [20 min, 10 min (37 J/cm²)]; Group C [1 hour, 10 min (37 J/cm²)]. Pain and AK lesion counts were recorded during two PDT treatments spaced 8 weeks apart. Final lesion counts were at 3-6 months.</p><p><strong>Results: </strong>At both treatment visits, Group A and B patients experienced negligible pain that was statistically less than that of Group C patients. AK clearance after two PDT treatments was robust and similar amongst the three treatment groups (76% for Group A, 74% for Group B, and 82% for Group C). Using a non-inferiority margin of 15%, lesion reduction in Group A was statistically non-inferior to Group C after one PDT treatment.</p><p><strong>Limitations: </strong>Efficacy rates of the new short incubation protocols (done without occlusion) were not compared directly with the long (3-hour) FDA-approved protocol that is done with occlusion.</p><p><strong>Conclusion: </strong>Short-contact red light PDT regimens are essentially painless and appear to provide very good AK lesion clearance.</p><p><strong>Clinical trial registration: </strong>NCT06027619 (date of trial registration: 31 August, 2023).</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104698"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-phacoemulsification examination of intraocular pathologies that could not be detected by fundus biomicroscopy or OCT in eyes with dense cataract, to avoid intra- and post-operative complications.","authors":"Sule Gokcek Gurturk Icoz, Sevde Akcay Usta, Mehmet Icoz","doi":"10.1016/j.pdpdt.2025.104696","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104696","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate postoperative intraocular pathologies in eyes with dense cataracts that preclude fundus evaluation.</p><p><strong>Design: </strong>Retrospective study.</p><p><strong>Methods: </strong>This study was conducted on 88 eyes from 88 patients.All participants underwent uncomplicated phacoemulsification and intraocular lens implantation due to dense cataracts that prevented fundus evaluation in biomicroscopic dilated fundus examination. In the postoperative first-month follow-up, intraocular pathologies were assessed via dilated biomicroscopic fundus examination, color fundus photography, and optical coherence tomography.Potential risk factors were identified using univariate and multivariate regression analyses.</p><p><strong>Results: </strong>The mean age of the patients was 69 ± 11 (range:28-92) years, with 49 being female. Intraocular pathologies were detected in 33 patients (37%).The most frequently observed pathologies were diabetic retinopathy (n=11, 13%), followed by age-related macular degeneration (n=7, 8%), epiretinal membrane (n=6, 7%), full-thickness or lamellar macular holes (n=3, 3%), photoreceptor damage (n=2, 2%), glaucomatous changes (n=2, 2%), myopic degeneration (n=1, 1%), and vitreomacular traction (n=1, 1%).Both univariate and multivariate regression analyses revealed diabetes mellitus and the presence of pathology in the fellow eye as significant risk factors for postoperative intraocular pathologies in patients with dense cataracts (p<0.05 and p<0.001,respectively).</p><p><strong>Conclusion: </strong>A considerable proportion of intraocular pathologies were detected postoperatively in eyes with dense cataracts.Diabetes mellitus and the presence of pathology in the fellow eye were found to be significant risk factors for postoperative intraocular pathologies in both univariate and multivariate regression analyses.These findings provide valuable evidence for clinicians and patients regarding postoperative intraocular pathologies in eyes with mature cataracts.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104696"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of severe prolonged hypotension induced by 5-aminolevulinic acid during photodynamic diagnosis-assisted transurethral resection of bladder tumor.","authors":"Hideo Fukuhara, Ryu Shigehisa, Kenta Saito, Takeshi Hara, Noboru Otsuka, Yoshifumi Katsumata, Takashi Kawano, Keiji Inoue","doi":"10.1016/j.pdpdt.2025.104667","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104667","url":null,"abstract":"<p><strong>Background: </strong>To identify the risk factors of severe prolonged hypotension induced by 5-aminolevulinic acid (ALA) for non-muscle invasive bladder cancer patients undergoing photodynamic diagnosis (PDD)-assisted transurethral resection of bladder tumor (TURBT).</p><p><strong>Methods: </strong>We retrospectively performed multivariate analyses to identify the clinical risk factors for ALA-induced severe prolonged hypotension, defined as requiring: (1) prolonged vasopressor treatment, (2) frequent treatment with vasopressor, and (3) continuous noradrenaline administration (systolic blood pressure < 80 mmHg) in bladder cancer patients undergoing PDD-TURBT.</p><p><strong>Results: </strong>A total of 245 patients who underwent PDD-TURBT were included in the final analysis. Risk factors (p < 0.05) by multivariate analyses were high body mass index, concomitant atrial fibrillation, low estimated glomerular filtration rate and short ALA exposure time. Predisposing risk factors (0.05 ≤ p < 0.2) on multivariate analysis included concomitant hypertension and use of calcium channel blockers. Analyses of the effect of combination of the four risk factors on the duration of vasopressor treatment showed patients with two or three risk factors significantly more frequently received vasopressor treatment for a duration of ≥ 60 min than those without risk factors (p < 0.05).</p><p><strong>Conclusions: </strong>We identified independent risk factors and combinations of multiple factors related to ALA-induced severe prolonged hypotension in bladder cancer patients undergoing PDD-TURBT. In patients with multiple risk factors, it is advisable to maintain a longer interval between ALA administration and anesthesia to avoid severe prolonged hypotension.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104667"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior Segment Characteristics and Spatial Variations of Different Crystalline Lens Diseases.","authors":"Jianxia Fang, Ce Shi, Xinyu Ma, Siting Sheng, Jingwei Xu, Sha Zhu, Yixuan Feng, Yu Zhang, Lirui Liu, Huiling Zhao, Zhe Xu, Wen Xu","doi":"10.1016/j.pdpdt.2025.104693","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104693","url":null,"abstract":"<p><strong>Introduction: </strong>To evaluate anterior chamber and crystalline lens morphology in patients with cataracts, lens subluxation (LS), and microspherophakia (MSP) using three anterior segment (AS) imaging instruments, and to develop a novel method for assessing the spatial characteristics of crystalline lens position through anterior chamber morphology measurements.</p><p><strong>Methods: </strong>We examined 98 eyes (19 normal, 25 cataracts, 27 LS, 27 MSP) using AS optical coherence tomography (AS-OCT), ultrasound biomicroscopy (UBM), and IOLMaster700. Measurements included corneal thickness, anterior chamber parameters, and lens thickness (LT). We introduced the coefficient of variation (CV) of anterior chamber angle (ACA) and angle open distance (AOD) to quantify lens dislocation, and generated lens position alteration maps using AS-OCT and UBM to visualize the extent and distribution of lens dislocation.</p><p><strong>Results: </strong>The LS and MSP groups showed significantly greater LT compared to normal and cataract groups (P < 0.05). The nasal ACA was reduced in LS and MSP groups, with MSP showing smaller nasal AOD compared to normal group (P < 0.05). Temporal ACA was significantly lower in the LS group compared to other groups (P < 0.05). AS-OCT measurements of ACA and AOD in the MSP group exceeded UBM values. The CV measurements and lens location alterations maps effectively illustrated the extent of lens dislocation and zonular weakness.</p><p><strong>Conclusion: </strong>Each condition showed distinct AS features. The CV of ACA and AOD, along with location alteration maps from wide-field AS-OCT and UBM, might serve as valuable tools in diagnosing lens dislocation-related diseases, identifying dislocation areas, and assessing zonular weakness.</p><p><strong>Trial registration number: </strong>NCT04833491 (ClinicalTrials.gov.).</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104693"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of topical photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA) for cervical intraepithelial neoplasia with human papillomavirus (HPV) infection: a retrospective comparative study versus loop electrosurgical excision procedure (LEEP).","authors":"Jue Li, Ying Huang, Jinxin Tao, Hangli Yang, Hua Zhu","doi":"10.1016/j.pdpdt.2025.104697","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104697","url":null,"abstract":"<p><p>Cervical intraepithelial neoplasia (CIN), driven by persistent human papillomavirus (HPV) infection, necessitates effective treatments that balance oncological efficacy with fertility preservation. This retrospective study evaluated 5-aminolevulinic acid photodynamic therapy (ALA-PDT) versus loop electrosurgical excision procedure (LEEP) in 171 patients with HPV-associated CIN. Participants were stratified into LSIL-PDT (n=61), HSIL-PDT (n=42), and HSIL-LEEP (n=68) groups, with outcomes assessed at 6 months. ALA-PDT demonstrated superior lesion remission (HSIL: 83.3% vs. LEEP's 64.7%, p<0.05) and HPV clearance (78.6% vs. 60.3%, p<0.05), particularly against HPV16/18 infections (OR=0.351, 95%CI:0.132-0.93). Crucially, ALA-PDT preserved cervical integrity, with 8/103 patients achieving uncomplicated pregnancies post-treatment, compared to 6/68 LEEP-treated patients, among whom adverse outcomes (e.g., preterm birth) occurred. The study highlights ALA-PDT's dual advantage: targeted eradication of high-risk HPV strains and minimal collateral tissue damage, critical for reproductive-age patients. Innovations include validating genotype-specific efficacy and demonstrating fertility preservation without compromising oncological outcomes. These findings position ALA-PDT as a safer, precision-based alternative to traditional excisional methods, offering significant clinical implications for CIN management and long-term patient quality of life. Future research should expand cohorts to confirm durability and explore broader applications in lower genital tract pathologies.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104697"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal changes in optical coherence tomography angiography before and after surgery for acute primary angle closure glaucoma.","authors":"Ke Yin, Haomin Chen, Yanxin Zhang, Li Xinyi, Su Ruihong, Yi Yue, Yingjuan Lv, Lijie Dong, Yi Shi, Aihua Liu","doi":"10.1016/j.pdpdt.2025.104692","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104692","url":null,"abstract":"<p><strong>Purpose: </strong>This study explored changes in retinal microvasculature in patients with Acute Primary Angle Closure (APAC) before and after surgery, assessing their correlation with variations in retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness, while also examining the effects of acute intraocular pressure elevation on ocular microvasculature.</p><p><strong>Patients and methods: </strong>This was a retrospective longitudinal study that assessed 22 APAC eyes undergoing phacoemulsification, intraocular lens implantation, and trabeculectomy, along with 22 healthy fellow eyes. Optical coherence tomography angiography was used to evaluate vessel density (VD) in the optic disc and macula preoperatively, and at one week and one month postoperatively. The thicknesses of RNFL and GCIPLwere also measured.</p><p><strong>Results: </strong>Postoperatively, the superficial vascular complex (SVC) VD, including the whole image VD (wiVD) of disc and macula, continued to decrease at one month (p<0.001, p=0.001). In contrast, at the deep vascular complex (DVC) level, only disc wiVD showed significant changes at one month (p=0.007). Changes in disc and macula wiVD at the SVC level were significantly correlated with changes in RNFL and GCIPL thickness (p=0.004, p<0.001; p=0.018, p=0.002), whereas VD at the DVC level was not. The SVC disc wiVD (AUROC=92.56%) had superior diagnostic performance compared to the DVC disc wiVD (AUROC=58.06%).</p><p><strong>Conclusions: </strong>We found acute intraocular pressure elevation has lasting effects on APAC eyes. Postoperative alterations in SVC VD seem to be more sensitive indicators for APAC patients.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104692"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of the correlation between dermoscopic vascular features and the response to hemoporfin-mediated photodynamic therapy in previously untreated children with port wine stains.","authors":"Sheng Zhang, Xiuwei Wang, Yijing Chen, Yuhan Wang, Jianyou Chen, Xiaoyan Liu, Gao Lei Zhang, Wei Su","doi":"10.1016/j.pdpdt.2025.104691","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104691","url":null,"abstract":"<p><strong>Background: </strong>Port wine stains (PWS) are congenital capillary malformations that affect the quality of life for children. Hemoporfin-mediated photodynamic therapy (HMME-PDT) is a promising therapeutic modality for patients with PWS. However, the variability in the clinical efficacy of HMME-PDT has necessitated further investigations into the factors influencing the therapeutic efficacy of this modality.</p><p><strong>Objectives: </strong>To explore the correlation between dermoscopic vascular features and the efficacy of HMME-PDT in previously untreated children with PWS.</p><p><strong>Methods: </strong>Clinical data were collected from children with PWS who were treated with HMME-PDT. Correlations between clinical efficacy and gender, age, lesion location, lesion color and dermoscopic vascular features were analyzed retrospectively in previously untreated children with PWS.</p><p><strong>Results: </strong>A total of 100 previously untreated children with PWS were enrolled, including 52 males and 48 females aged between 1 and 14 years. The efficacy of HMME-PDT differed significantly in relation to lesion location and color of the PWS (P<0.05). Sausage-like vessels (66.67%), dotted and globular vessels (87.50%) and linear vessels (50.00%) were associated with excellent treatment outcomes. Reticular vessels (65.00%) showed improved outcomes. HMME-PDT was not effective in some cases with homogeneous reddish background (35.71%) features. No serious adverse events and recurrences were observed following HMME-PDT.</p><p><strong>Conclusion: </strong>The dermoscopic vascular features showed a significant correlation with the effectiveness of HMME-PDT in previously untreated children with PWS. Thus, the vascular features of PWS classified by dermoscopy can provide helpful clinical information to evaluate the efficacy of HMME-PDT and develop individualized treatment program for children with PWS.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104691"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations of retinal microvascular density in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis.","authors":"Kaibao Ji, Yi Zhao, Hongli Liu, Qinglin Zhang, Yang Yang, Wei Wan","doi":"10.1016/j.pdpdt.2025.104690","DOIUrl":"https://doi.org/10.1016/j.pdpdt.2025.104690","url":null,"abstract":"<p><strong>Background: </strong>The present study aimed to evaluate retinal microvascular alterations in patients with chronic obstructive pulmonary disease (COPD) utilizing optical coherence tomography angiography (OCTA).</p><p><strong>Methods: </strong>Pertinent articles comparing retinal vascular characteristics between eyes of COPD patients and healthy controls were systematically retrieved from PubMed, Embase, the Cochrane Library, and Web of Science from inception until June 2024. For continuous variables, mean differences with 95% confidence intervals were calculated using Review Manager Version 5.4.</p><p><strong>Results: </strong>A total of six eligible studies encompassing 530 eyes (279 eyes in the COPD group and 251 eyes in the control group) were included in the meta-analysis. The analysis revealed a significant reduction in macular whole enface vessel density (VD) measured by OCTA in COPD patients compared to controls, with pooled mean differences of -2.16 (P= 0.04) for superficial VD and -2.93 for deep VD (P= 0.01). Additionally, combined values for parafoveal and perifoveal deep VD measured by OCTA were significantly lower in COPD patients than those observed in normal controls (MD= -2.31, P= 0.003; MD= -3.79, P= 0.03 respectively). Furthermore, pooled results indicated that radial peripapillary capillary (RPC) whole image VD, RPC inside disc VD, and RPC peripapillary VD detected by OCTA were markedly decreased in the COPD cohort compared to controls (MD= -1.68, P< 0.0001; MD= -2.14, P= 0.003; MD= -1.86, P= 0.0002 respectively).</p><p><strong>Conclusion: </strong>Our findings indicate that individuals with COPD exhibit reduced vessel densities both within macular regions and at the optic nerve head area, thereby suggesting that OCTA metrics can serve as a potential auxiliary tool for diagnosing COPD due to their non-invasive nature and rapid assessment capabilities, especially if confounding diseases that can also affect retinal vessel densities are considered with care.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"104690"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}