Efficacy and empirical analysis of electrodesiccation combined with photodynamic therapy in the treatment of high-risk basal cell carcinoma

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-07-24 DOI:10.1016/j.pdpdt.2025.104730

Xiaojie Liu , Junru Liu , Lyuye Liu , Jipeng Yu , Dejing Gao , Tianyuan Zhou , Weibin Xing

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Abstract

Background

Basal cell carcinoma (BCC) is the most common non-pigmented cutaneous malignancy.ALA-PDT has significant advantages in the treatment of BCC, but it is limited by the size and depth of the tumor. Combination therapy can improve the efficacy of PDT in treating BCC and overcome its limitations.

Methods

A retrospective study was conducted to analyze the feasibility of ET combined with ALA-PDT in the treatment of high-risk BCC in terms of efficacy, aesthetic outcome, patient satisfaction, quality of life, and adverse reactions.

Results

High-risk BCC treated with ET combined with ALA-PDT showed a cure rate of 98.55 % and a recurrence rate of 1.45 % at 1 year or more (average follow-up of 31 months). The treatment showed excellent aesthetic results (scar score of 1.87) and high patient satisfaction (8.03). The quality of life of the treated patients significantly improved compared to the pre-treatment period (DLQI of 13.03 and 1.94 points), and the difference was statistically significant. The average healing time was 16.81 days after treatment. The main adverse reactions were moderate pain (4.90 points) and local redness and swelling, and no infection was observed.

Conclusion

ET combined with PDT showed remarkable efficacy in the treatment of high-risk BCC. The combination provides rapid healing, less scarring, and good aesthetic outcomes, which can be used as a clinical choice for treating high-risk BCC. However, it still needs to be verified in studies with larger sample sizes and longer follow-up periods.

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电干燥联合光动力疗法治疗高危基底细胞癌的疗效及实证分析。

背景：基底细胞癌（BCC）是最常见的非色素性皮肤恶性肿瘤。ALA-PDT治疗BCC有显著优势，但受肿瘤大小和深度的限制。联合治疗可提高PDT治疗BCC的疗效，克服其局限性。方法：回顾性分析ET联合ALA-PDT治疗高危BCC的疗效、美观效果、患者满意度、生活质量及不良反应的可行性。结果：ET联合ALA-PDT治疗高危BCC， 1年及以上治愈率为98.55%，复发率为1.45%（平均随访31个月）。术后美观性好（疤痕评分1.87），患者满意度高（8.03）。治疗后患者的生活质量较治疗前明显改善（DLQI分别为13.03分和1.94分），差异有统计学意义。治疗后平均愈合时间16.81 d。主要不良反应为中度疼痛（4.90分），局部红肿，未见感染。结论：ET联合PDT治疗高危基底细胞癌疗效显著。该组合可提供快速愈合，瘢痕较少和良好的美观效果，可作为治疗高危BCC的临床选择。但仍需在样本量更大、随访时间更长的研究中进行验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.