Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Long-Term retrospective analysis of retinal pigment epithelium atrophy and secondary hyperplasia following verteporfin photodynamic therapy","authors":"Sung-Ting Hsu ,&nbsp;Lee-Jen Chen ,&nbsp;Wei-Chun Chan ,&nbsp;Yung-Jen Lai ,&nbsp;Fang-Yi Chiu ,&nbsp;Ning Chiu ,&nbsp;Hsiang-Ling Tsai","doi":"10.1016/j.pdpdt.2025.104576","DOIUrl":"10.1016/j.pdpdt.2025.104576","url":null,"abstract":"<div><h3>Purpose</h3><div>To identify risk factors for retinal pigment epithelium (RPE) atrophy associated with verteporfin photodynamic therapy (PDT), with or without secondary RPE hyperplasia, and to evaluate long-term visual outcomes.</div></div><div><h3>Materials and methods</h3><div>This retrospective study analyzed 197 eyes of 180 patients who underwent verteporfin PDT between 2000 and 2023. Baseline demographic and clinical characteristics were evaluated.</div></div><div><h3>Results</h3><div>Among 197 eyes that underwent one or more sessions of PDT, PDT-induced RPE atrophy was observed in 2 eyes (2.4 %) with wet age-related macular degeneration (wet AMD) or polypoidal choroidal vasculopathy (PCV) and in 1 eye (3.8 %) with central serous chorioretinopathy (CSC). In contrast, 18 eyes (22.2 %) with myopic choroidal neovascularization (mCNV) developed PDT-induced RPE atrophy. Subgroup analysis revealed that in the mCNV group, patients with PDT-induced RPE atrophy were significantly younger (36.5 ± 13.7 years vs. 46.3 ± 12.8 years; <em>P</em> &lt; 0.001) and underwent more PDT sessions (2.6 ± 1.8 vs. 1.5 ± 0.8; <em>P</em> &lt; 0.001) than those without atrophy. Five patients developed secondary RPE hyperplasia, all from the mCNV group.</div></div><div><h3>Conclusion</h3><div>Verteporfin PDT rarely induces RPE atrophy in patients with wet AMD, PCV, and CSC. However, in patients with myopic CNV, PDT may occasionally cause alterations in the RPE, including both atrophy and secondary hyperplasia. While PDT-induced RPE atrophy was not a statistically significant predictor of best-corrected visual acuity at the final follow-up in the mCNV and wet AMD/PCV groups in the linear regression analysis, it was a significant factor in the CSC group.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104576"},"PeriodicalIF":3.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of photodynamic therapy mediatied by 5-aminolevulinic acid for the treatment of cervical intraepithelial neoplasia 3(CIN 3): A single-center, prospective, cohort study","authors":"Qin Han ,&nbsp;Tongxia Wang ,&nbsp;Zhangxin Wu ,&nbsp;Jiaxin Shi ,&nbsp;Xue Zhang ,&nbsp;Hongyan Guo","doi":"10.1016/j.pdpdt.2025.104573","DOIUrl":"10.1016/j.pdpdt.2025.104573","url":null,"abstract":"<div><h3>Background</h3><div>Cervical intraepithelial neoplasia grade 3(CIN 3) is a precancerous lesion condition with high progression rate and is advised to be treated immediately. Because traditional treatments have limited effects or complications, here we evaluated the efficacy and safety of topical 5-aminolevulinic acid (ALA)–based photodynamic therapy (PDT).</div></div><div><h3>Methods</h3><div>This study consisted of 56 female patients diagnosed with CIN3. A 20 % 5-ALA jelly formation was topically applied to the cervix, followed by 635 nm PDT at 7-14 days intervals. Cytology, human papillomavirus (HPV) genotyping, colposcopy, and pathology were assessed after treatment.</div></div><div><h3>Results</h3><div>Among the 56 patients in our study, 26.8 % (15/56) patients had disease remission after just one course PDT, 69.6 % (39/56) patients had partial remission to CIN2, which suggested a response to the therapy and should be treated with more course. The total pathological regression rate was 89.3 %(50/56). Although6 patients did CKC finally, none of the pathology suggest cervical cancer and 2 of them were LSIL. The HPV clearance rate during the 6-month follow-up was 51.8 %. 4 patients had recurrent disease during the 2-year follow-up time point. The most common adverse event was increased vaginal discharge, other side effects include abdominal pain, vulvar pruritus, and vaginal bleeding. No severe adverse effect was observed during the treatment.</div></div><div><h3>Conclusion</h3><div>ALA-PDT is a treatment option for CIN 3 which meet certain conditions, with the main goal to preserve the struction and founction of cervix.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104573"},"PeriodicalIF":3.1,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rose Bengal photodynamic antimicrobial therapy as an adjunct treatment for Pseudomonas aeruginosa infectious necrotizing scleritis","authors":"Salomon Merikansky ,&nbsp;Carolina Mercado ,&nbsp;Heather Durkee ,&nbsp;Rudolf Kobus ,&nbsp;Juan Carlos Navia ,&nbsp;Alejandro Arboleda ,&nbsp;Mariela C. Aguilar ,&nbsp;Jaime D. Martinez ,&nbsp;Harry W. Flynn ,&nbsp;Darlene Miller ,&nbsp;Jean-Marie Parel ,&nbsp;Guillermo Amescua","doi":"10.1016/j.pdpdt.2025.104575","DOIUrl":"10.1016/j.pdpdt.2025.104575","url":null,"abstract":"<div><div>Purpose To report the utility of Rose Bengal Photodynamic Antimicrobial Therapy (RB-PDAT) as an adjunct treatment in rapidly progressing Infectious Necrotizing Scleritis (INS) secondary to <em>Pseudomonas aeruginosa</em>. Methods Retrospective chart review was conducted on consecutive patients with scleritis and culture-proven <em>Pseudomonas aeruginosa</em> who underwent RB-PDAT. Results Six patients with <em>Pseudomonas aeruginosa</em> INS were included. All patients achieved complete resolution of the infection. The mean time to resolution after RB-PDAT was 17 days (range; 6–30 days), with a total treatment course average of 36 days (range; 22–60 days). One patient with pan-resistant Pseudomonas sclerokeratitis required two RB-PDAT treatments due to persistent stromal melting. All patients received a standardized regimen of oral fluoroquinolone, topical tobramycin, and ciprofloxacin/moxifloxacin. The patient with pan-resistant <em>Pseudomonas aeruginosa</em> required treatment with topical imipenem as well. None of the patients required enucleation. Conclusion RB-PDAT is a feasible option to halt the progression of infectious necrotizing scleritis caused by <em>Pseudomonas aeruginosa</em>, especially in cases of impending perforation.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104575"},"PeriodicalIF":3.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of optic disc parameters, circumpapillary retinal nerve fiber layer (cpRNFL) and ganglion cell complex (GCC) in refractive error using SS-OCT: Magnification-corrected analysis","authors":"Jingyu Mu ,&nbsp;Jing Wei ,&nbsp;Zengrui Zhang ,&nbsp;Haoming Geng ,&nbsp;Fengyuan Yu ,&nbsp;Junguo Duan","doi":"10.1016/j.pdpdt.2025.104580","DOIUrl":"10.1016/j.pdpdt.2025.104580","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To observe and analyze the characteristics of optic disc parameters, circumpapillary retinal nerve fiber layer (cpRNFL), and macular ganglion cell complex (GCC) thickness in children and adolescents aged 4–17 years with refractive errors using magnification-corrected swept-source optical coherence tomography (SS-OCT).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This cross-sectional study included 286 refractive error subjects (286 eyes) aged 4–17 years. The participants were divided into three groups based on spherical equivalent (SE):non-myopia group (-0.5D &lt; SE &lt; +2.0D, 77eyes), low myopia group (-3.0D &lt; SE ≤ -0.5D, 164 eyes), and moderate-to-high myopia group (SE ≤ -3.0D, 45 eyes). SS-OCT was used to evaluate optic disc parameters, cpRNFL and macular GCC thickness, with magnification correction applied to adjust these parameters. Multivariable linear regression was performed to analyze the correlation between optic disc parameters, cpRNFL and macular GCC thickness with age, gender, intraocular pressure (IOP), axial length (AL), keratometry (K), and anterior chamber depth (ACD) before and after magnification correction.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The mean age of the participants was 9.64 ± 2.62 years. After magnification correction, the mean cpRNFL, macular GCC thickness, optic disc area, and rim area were 116.87 ± 11.13 μm, 115.90 ± 6.77 μm, 2.04± 0.58 mm², and 1.32 ± 0.50 mm², respectively. Multivariable linear regression models, adjusted for age, gender, and other ocular parameters, revealed the following findings, before magnification correction, the mean cpRNFL thickness was positively correlated with SE (β = 1.33) and negatively correlated with AL (β = -3.60, both &lt;em&gt;P&lt;/em&gt; &lt; 0.05),after magnification correction, no significant correlations were found between cpRNFL thickness and SE or AL (both &lt;em&gt;P&lt;/em&gt; &gt; 0.05).For macular GCC thickness, both before and after magnification correction, a positive correlation with SE (β range:0.677 to 1.011) and a negative correlation with AL (β range:2.667to -1.929) were observed (both &lt;em&gt;P&lt;/em&gt; &lt; 0.05).For optic disc area and rim area, no significant correlations with SE or AL were observed before magnification correction. However, after magnification correction, both optic disc area and rim area were negatively correlated with SE (β = -0.058 and -0.057, respectively) and positively correlated with AL (β = 0.169and 0.182, both &lt;em&gt;P&lt;/em&gt; &lt; 0.05).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;In the children and adolescents, after magnification correction, macular GCC thickness demonstrated a negative correlation with increasing myopic degree and AL elongation, while optic disc and rim areas showed positive correlations. However, no significant correlation was observed in cpRNFL thickness. Given that ocular development and remodeling are still ongoing in children and adolescents, interpretation of disc-related parameters and macular GCC thickness requires c","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104580"},"PeriodicalIF":3.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic therapy for flat warts arising on a tattoo","authors":"Federica Li Pomi ,&nbsp;Andrea d'Aloja ,&nbsp;Mario Vaccaro ,&nbsp;Francesco Borgia","doi":"10.1016/j.pdpdt.2025.104574","DOIUrl":"10.1016/j.pdpdt.2025.104574","url":null,"abstract":"<div><div>Cutaneous warts are common benign lesions caused by human papillomavirus (HPV). While treatments such as cryotherapy, laser therapy, and electrosurgery can be effective, they may be unsuitable for warts over tattooed skin due to the risk of pigmentary alterations and scarring. Photodynamic therapy (PDT) is a non-invasive treatment that selectively targets HPV-infected keratinocytes, minimizing damage to surrounding tissue. However, no studies have specifically evaluated PDT for warts on tattooed skin. We report the case of a 25-year-old male with multiple flat warts over a long-standing tattoo on his forearm, successfully treated with three sessions of conventional PDT using 10 % aminolevulinic acid (ALA) ointment (Biosynth AG, Staad, Switzerland). Irradiation was applied with diode red light at 630 nm in wavelength (S630, Alpha Strumenti, Milan, Italy). The light source was positioned at 50 mm from the skin surface, which gave a skin irradiance of about 160 mW/cm². The light exposure period was 8 min, resulting in a total light dose of 75 J/cm². The procedure was well tolerated by the patient, who complained of only a mild burning sensation during light exposure. At three-month follow-up, complete wart clearance was observed, with no tattoo distortion or recurrence at one year. This case highlights the potential of PDT as a first-line treatment for warts in cosmetically sensitive areas, offering effective viral clearance while preserving tattoo integrity. Further studies are warranted to validate its efficacy in larger cohorts and establish standardized treatment protocols for tattooed skin.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104574"},"PeriodicalIF":3.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) for assessing thyroid-associated ophthalmopathy activity","authors":"Huihui Wu ,&nbsp;Qinglu Song ,&nbsp;Ye Zhang ,&nbsp;Ruiwen Cheng ,&nbsp;Yuanyuan Li ,&nbsp;Mengru Su ,&nbsp;Xiaowen Zhang ,&nbsp;Xinghong Sun","doi":"10.1016/j.pdpdt.2025.104578","DOIUrl":"10.1016/j.pdpdt.2025.104578","url":null,"abstract":"<div><h3>Purpose</h3><div>To explore the role of retinal and choroidal parameters obtained via optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in predicting thyroid-associated ophthalmopathy (TAO) activity, providing a scientific basis for improved clinical diagnosis and treatment.</div></div><div><h3>Method</h3><div>This study included 90 active TAO patients (178 eyes), 69 inactive TAO patients (138 eyes), and 66 healthy individuals (132 eyes). It compared choroidal and retinal parameters and magnetic resonance imaging structural differences, analyzed correlations between these parameters, and developed a predictive model for TAO activity.</div></div><div><h3>Results</h3><div>Compared to control and inactive groups, active group had thicker subfoveal choroidal thickness (SFCT) and reduced luminal area, stromal area, and total choroidal area. Active group showed reduced vessel density in the foveal and nasal regions versus inactive group, and in the foveal, superior, and nasal regions versus controls. Foveal avascular zone (FAZ) area was larger in active group than in both control and inactive groups. Active group also had larger inner diameters and signal intensity ratio (SIR) of the extraocular muscles than inactive group. SFCT correlated with proptosis, and FAZ correlated with proptosis, maximum extraocular muscle diameter, and SIR. The multivariate model achieved area under the curve values of 0.836 in overall TAO population and 0.855 in hyperlipidemia subgroup, outperforming the univariate model.</div></div><div><h3>Conclusion</h3><div>Retinal and choroidal parameters, obtained via OCT/OCTA, are keys to developing TAO activity predictive models, with enhanced accuracy in TAO patients with hyperlipidemia.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104578"},"PeriodicalIF":3.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on “Hematoporphyrin derivative-photodynamic therapy (HpD-PDT) for extensive vulvar and vaginal Bowen's disease: A case report”","authors":"Jiayuan Zhang ,&nbsp;Atsushi Tomokiyo","doi":"10.1016/j.pdpdt.2025.104581","DOIUrl":"10.1016/j.pdpdt.2025.104581","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104581"},"PeriodicalIF":3.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory multimodal nonlinear microscopy: Coherent anti-stokes Raman scattering, second harmonic generation, and differential interference contrast for oral squamous cell carcinoma diagnosis","authors":"Hangzhe Song ,&nbsp;Xiaoxiao Li ,&nbsp;Tao Yang ,&nbsp;Lifu Shao ,&nbsp;Zhigang Sun ,&nbsp;Penglong Cao ,&nbsp;Rui Li ,&nbsp;Juntao Ma","doi":"10.1016/j.pdpdt.2025.104577","DOIUrl":"10.1016/j.pdpdt.2025.104577","url":null,"abstract":"<div><h3>Objective</h3><div>We applied multimodal nonlinear optical microscopy and Raman Spectroscopy to rapidly image Oral Squamous Cell Carcinoma (OSCC), comparing results with Hematoxylin-Eosin (H&amp;E) stained to explore supplementary diagnostic methods.</div></div><div><h3>Study Design</h3><div>With ethical approval and patient informed consent, we processed primary tumor resection tissues, preparing frozen sections. Slice 1 was stained with H&amp;E-stained, while Slice 2 was unstained and imaged using Coherent anti-Stokes Raman Scattering (CARS), Second-Harmonic Generation (SHG), Differential Interference Contrast (DIC), and Raman spectroscopy. These were analyzed alongside H&amp;E-stained sections to assess diagnostic capabilities.</div></div><div><h3>Results</h3><div>Raman spectroscopy revealed distinct differences at 646, 798, 1006, 1091, 1157, 1190, 1450, 1520, and 1660 cm^-1. CARS imaging showed unique cancer nest structures, and SHG highlighted collagen fiber distribution.</div></div><div><h3>Conclusions</h3><div>Multimodal nonlinear imaging, combining CARS, SHG, and DIC, shows potential as a supplementary diagnostic tool for oral squamous cell carcinoma, aiding in the characterization of pathological features and providing valuable clinical diagnostic information.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104577"},"PeriodicalIF":3.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Fourier transform infrared spectroscopy on Breast cancer diagnosis combined with multiple algorithms: A systematic review","authors":"Yeniewa Kerie Anagaw ,&nbsp;Gizachew Kassahun Bizuneh ,&nbsp;Melaku Getahun Feleke ,&nbsp;Liknaw Workie Limenh ,&nbsp;Derso Teju Geremew ,&nbsp;Minichil Chanie Worku ,&nbsp;Melese Legesse Mitku ,&nbsp;Misganaw Gashaw Dessie ,&nbsp;Biset Asrade Mekonnen ,&nbsp;Wondim Ayenew","doi":"10.1016/j.pdpdt.2025.104579","DOIUrl":"10.1016/j.pdpdt.2025.104579","url":null,"abstract":"<div><h3>Introduction</h3><div>Fourier transform infrared (FT-IR) spectroscopy is an innovative diagnostic technique for improving early detection and personalized care for breast cancer patients. It allows rapid and accurate analysis of biological samples. Therefore, the purpose of this study was to assess the diagnostic accuracy of FT-IR spectroscopy for breast cancer, based on a comprehensive literature review.</div></div><div><h3>Methods</h3><div>An online electronic database systematic search was conducted using PubMed/Medline, Cochrane Library, and hand databases from March 28, 2024, to April 10, 2024. We included peer-reviewed journal articles in which FT-IR spectroscopy was used to acquire data on breast cancers and manuscripts published in English. All eligible studies were assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool.</div></div><div><h3>Results</h3><div>Serum, breast biopsies, blood plasma, specimen, and saliva samples were included in this study. This study revealed that breast cancer diagnosis using FT-IR spectroscopy with diagnostic algorithms had a sensitivity and specificity of approximately 98 % and 100 %, respectively. Almost all studies have used more than one algorithm to analyze spectral data. This finding showed that the sensitivity of FT-IR spectroscopy reported in six included studies was greater than 90 %.</div></div><div><h3>Conclusion</h3><div>Employing multivariate analysis coupled with FT-IR spectroscopy has shown promise in differentiating between healthy and cancerous breast tissue. This review revealed that FT-IR spectroscopy will be the next gold standard for breast cancer diagnosis. However, to draw definitive conclusions, larger-scale studies, external validation, real-world clinical trials, legislative considerations, and alternative methods such as Raman spectroscopy should be considered.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104579"},"PeriodicalIF":3.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography findings of macula and neural changes in cryptococcal meningitis","authors":"Simin Gu ,&nbsp;Yaqi Cheng ,&nbsp;Huini Zhang,&nbsp;Jiayi Lin,&nbsp;Tao Wang,&nbsp;Shiqi Ling","doi":"10.1016/j.pdpdt.2025.104572","DOIUrl":"10.1016/j.pdpdt.2025.104572","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the structures and neural changes in cryptococcal meningitis (CM) patients compared with healthy controls.</div></div><div><h3>Design</h3><div>Retrospective, cross-sectional, cohort study.</div></div><div><h3>Methods</h3><div>Seventy-six eyes of 39 CM patients were included in this observational clinical cohort study. Thirty eyes of 16 CM patients with papilledema were included in Group 1, and 46 eyes of 23 CM patients without papilledema were included in Group 2. Another 80 eyes of 40 healthy participants were included in Group 3 as controls. Optical coherence tomography (OCT) images were obtained from all the participants via a DRI OCT Triton 3D device with its prototype IMAGEnet 6 for OCT software.</div></div><div><h3>Results</h3><div>Compared with those of the controls, the peripapillary retinal nerve fiber layer thickness (pRNFLT), peripapillary GCL++ thickness [pGCL++T, including the RNFL, ganglion cell layer (GCL), and inner plexiform layer (IPL)], peripapillary GCL+ thickness (pGCL+T, including the RNFL and IPL) and peripapillary choroidal thickness (pCT) were dramatically increased in CM patients with papilledema but decreased in those from CM patients with no papilledema. There was a similar trend in macular GCL++ thickness (mGCL++T) and macular GCL+ thickness (mGCL+T) in CM absent from optic swelling when compared with healthy controls.</div></div><div><h3>Conclusion</h3><div>Papilledema may or may not be present depending on the timing of the evaluation, and the ophthalmologic manifestations of CM with papilledema can be well observed. However, changes in the optic nerve head (ONH) and peripapillary structures in CM patients with no papilledema can be detected by optical coherence tomography. Parameters such as pRNFLT, pGCL++T, pGCL+T and pCT may provide useful evidence for the early detection of structures and neural impairments in patients with CM.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104572"},"PeriodicalIF":3.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}