Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Hyperspectral imaging combined with residual-attention-net for spectral-spatial feature fusion in liver disease diagnosis","authors":"Yunze Li ,&nbsp;Jingjing Wang ,&nbsp;Miaoqing Zhao ,&nbsp;Jinlin Deng ,&nbsp;Chongxuan Tian ,&nbsp;Qize Lv ,&nbsp;Yifei Liu ,&nbsp;Kun Ru ,&nbsp;Wei Li","doi":"10.1016/j.pdpdt.2025.104645","DOIUrl":"10.1016/j.pdpdt.2025.104645","url":null,"abstract":"<div><div>Distinguishing well-differentiated hepatocellular carcinoma (HCC) from cirrhosis is critical for effective treatment. However, while pathological morphology remains the gold standard, it has limitations in differentiating these two conditions. This study aims to propose a novel hyperspectral image (400–1000 nm) processing method based on 3D-Residual-attention networks (3D Ra-Net) to improve the accuracy of differentiation between the two.The study employs a 3D Ra-Net model that integrates spectral features with spatial information to enhance classification accuracy. We incorporated band selection techniques, including the Norris derivative and the Successive Projections Algorithm (SPA), and optimized the data processing workflow. Experimental performance was evaluated using cross-validation, with the primary metrics of accuracy, sensitivity, and specificity for statistical analysis. The experimental results demonstrate that the 3D Ra-Net model achieved a classification accuracy of 92.11 % in distinguishing well-differentiated HCC from cirrhosis. Additionally, the model achieved an accuracy of 84.67 % in distinguishing well-differentiated HCC, poorly differentiated HCC, cirrhosis, and normal liver tissue. Sensitivity and specificity values also indicated strong diagnostic performance. The key innovation of this study lies in the development of the 3D Ra-Net model and the efficient extraction of joint spatial-spectral features. This method provides a novel, effective approach for the accurate diagnosis of HCC, offering reliable potential for clinical application in liver disease diagnosis.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104645"},"PeriodicalIF":3.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of laser therapy for infantile hemangiomas: A systematic review of clinical outcomes and treatment considerations","authors":"Alain Chaple Gil ,&nbsp;Rodrigo Caviedes ,&nbsp;Leonardo Díaz ,&nbsp;Alfredo Von Marttens ,&nbsp;Claudio Sotomayor ,&nbsp;Javier Basualdo ,&nbsp;Víctor Beltrán ,&nbsp;Gilbert Jorquera ,&nbsp;Cristian Bersezio ,&nbsp;Pablo Angel ,&nbsp;Rodrigo Cabello Ibacache ,&nbsp;Eduardo Fernández","doi":"10.1016/j.pdpdt.2025.104637","DOIUrl":"10.1016/j.pdpdt.2025.104637","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Infantile hemangiomas (IHs) are the most common benign vascular tumors in infancy. While many resolve spontaneously, treatment is often required due to ulceration, functional impairment, or aesthetic concerns. Laser therapy, either alone or in combination with beta-blockers, has become a central therapeutic option. However, optimal laser parameters, efficacy for different IH types, and safety remain under investigation. This systematic review evaluates the effectiveness and safety of various laser treatments for IHs, focusing on lesion regression, treatment protocols, recurrence, and adverse events.</div></div><div><h3>Study design/materials and methods</h3><div>A systematic search was conducted following PRISMA guidelines in PubMed, Scopus, Web of Science, Embase, and the Cochrane Library. Studies published up to January 2025 were included. This review included 20 studies comprising a total of 2856 patients. Included clinical studies evaluated laser therapy—alone or combined with pharmacological agents—and reported outcomes such as lesion regression, treatment duration, recurrence, and adverse effects.</div></div><div><h3>Results</h3><div>The 595-nm pulsed dye laser (PDL) was the most studied and showed high efficacy for superficial IHs, with improvement rates up to 85 %. The 1064-nm Nd:YAG laser was more effective for deeper lesions, achieving up to 87.57 % regression. Combination therapies (e.g., PDL with propranolol or timolol) yielded better outcomes than monotherapy, with higher regression and lower recurrence. Dual-wavelength approaches also showed promise. Adverse effects were generally mild and infrequent.</div></div><div><h3>Conclusion</h3><div>Laser therapy is effective and well-tolerated for IHs. PDL is preferred for superficial lesions and Nd:YAG for deeper or mixed types. Standardized protocols are needed, and further research should refine therapeutic parameters and clinical guidelines.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104637"},"PeriodicalIF":3.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fire needle pretreatment combined with ALA-PDT for Penile Bowen's disease: A case report","authors":"Tianming Ma ,&nbsp;Xiaoqing Xiang ,&nbsp;Yanliang Li ,&nbsp;Runqun Liu ,&nbsp;Yunyun Cao","doi":"10.1016/j.pdpdt.2025.104631","DOIUrl":"10.1016/j.pdpdt.2025.104631","url":null,"abstract":"<div><div>Bowen's disease (BD), squamous cell carcinoma (SCC) in situ, presents treatment challenges when located on the penis. Primarily concerning potential scarring and functional impairment following standard surgical excision (e.g., Mohs micrographic surgery). Aminolevulinic acid photodynamic therapy (ALA-PDT) may provide a valuable alternative, especially for this sensitive anatomical site. This report describes the successful treatment of a case of penile BD using fire needle pretreatment immediately preceding ALA-PDT. The patient achieved complete clinical and histological remission and remained disease-free at 2 years of follow-up.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104631"},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which treatment works better for Meibomian Gland Dysfunction: LipiFlow or intense pulsed light? A systematic review and network meta-analysis","authors":"Kai-Yang Chen ,&nbsp;Hoi-Chun Chan ,&nbsp;Chi-Ming Chan","doi":"10.1016/j.pdpdt.2025.104630","DOIUrl":"10.1016/j.pdpdt.2025.104630","url":null,"abstract":"<div><h3>Background</h3><div>Meibomian Gland Dysfunction (MGD) is a common cause of evaporative dry eye disease. Intense Pulsed Light (IPL) and LipiFlow thermal pulsation are two device-based treatment modalities currently used for managing MGD. This systematic review and meta-analysis aimed to assess and compare the efficacy of these interventions. It is important to underscore that none of the 12 studies included in this review directly compare LipiFlow with IPL, making indirect comparisons necessary.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed, Google Scholar, and ScienceDirect for randomized controlled trials (RCTs) assessing either IPL or LipiFlow for MGD, published up to February 2025. Study quality was appraised using the Cochrane Risk of Bias (RoB 2) tool. A random-effects meta-analysis was conducted for primary outcomes including TBUT (tear breakup time), SPEED (Standard Patient Evaluation of Eye Dryness) score, and OSDI (Ocular Surface Disease Index). A Bayesian network meta-analysis (NMA) was performed to enable indirect comparison between IPL and LipiFlow.</div></div><div><h3>Results</h3><div>Twelve RCTs involving 969 patients (1938 eyes) were included. Six studies assessed LipiFlow and six assessed IPL, but none provided a head-to-head comparison. LipiFlow significantly improved TBUT (MD: +0.67s; 95% CI: [0.08, 1.26], p=0.03) and reduced OSDI scores (MD: –6.07; 95% CI: [–10.85, –1.29], p=0.01), though changes in SPEED score were not statistically significant (p=0.15). IPL demonstrated superior efficacy in increasing TBUT (MD: +2.08s; 95% CI: [0.39, 3.71], p=0.02) and reducing SPEED scores (MD: –2.9; 95% CI: [–5.18, –0.64], p=0.01), while OSDI results were not significant. Control groups across studies varied greatly, ranging from untreated controls to warm compresses, eyelid hygiene, or mechanical expression, further complicating cross-study comparisons. However, these conclusions are based solely on indirect comparisons, which should be interpreted cautiously given the absence of head-to-head studies and the heterogeneity of control interventions.</div></div><div><h3>Conclusions</h3><div>While both IPL and LipiFlow showed improvements over controls in treating MGD, there is currently no direct comparative evidence between these modalities. As a result, any comparative conclusions must be interpreted with caution. The variability in control group interventions across studies (e.g., untreated vs. warm compresses or eyelid hygiene) introduces significant heterogeneity, reducing the certainty of indirect comparisons. Direct head-to-head RCTs are urgently needed to establish the relative efficacy of these interventions.</div></div><div><h3>Systematic Review Registration</h3><div>PROSPERO registration number: CRD42024543448</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104630"},"PeriodicalIF":3.1,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the therapeutic effect of repeated photodynamic therapy-assisted SRP treatments on class II furcation","authors":"Yikuan Wu ,&nbsp;Haoyu Li ,&nbsp;Yixiang Wang,&nbsp;Beiying Zhang,&nbsp;Chunsheng Bi,&nbsp;Xiaojun Li","doi":"10.1016/j.pdpdt.2025.104629","DOIUrl":"10.1016/j.pdpdt.2025.104629","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to evaluate whether repeated photodynamic therapy (PDT) ad-junctive to periodontal scaling and root planing (SRP) provides additional short-term clinical benefits for teeth with class II furcation involvement (FI).</div></div><div><h3>Materials and methods</h3><div>This single-center randomized controlled trial enrolled 27 patients (85 Class II FI sites), randomly allocated to receive either scaling and root planing (SRP) with adjunctive photodynamic therapy (PDT) at baseline, 1, and 2 weeks (Group A) or SRP alone (Group B). Each photodynamic therapy session involved injecting 0.1 mg/mL methylene blue as a photosensitizer into the periodontal pocket, followed by irradiation with a 660±10 nm wavelength laser at a power of 160-220 mW for 60 s. Clinical outcomes (bleeding on probing [BOP %], probing depth [PD], clinical attachment loss [CAL]) and gingival crevicular fluid (GCF) biomarkers (IL-4, IL-6) were assessed. Subgingival microbiota was analyzed via 16S rRNA sequencing, while patient-reported outcomes (PROs) included Visual Analog Scale (VAS) and oral health impact (OHIP-14).</div></div><div><h3>Results</h3><div>At the 3-month follow-up, Group A demonstrated significantly lower BOP % (33.33 % vs. 55.81 %; p&lt;0.05) and PD reduction (1.26±0.62 mm vs. 0.95±0.65 mm; p&lt;0.05) compared to Group B. However, no significant intergroup differences were observed in CAL (p&gt;0.05). Analysis of GCF revealed a significant time × group interaction in cytokine expression (p&lt;0.001), with Group A showing more favorable inflammatory modulation. Microbiological assessment indicated a marked reduction in periodontal pathogens and improved microbial diversity in Group A (p&lt;0.05). Patient-reported outcomes (PROs) demonstrated comparable therapeutic pain perception and postoperative fatigue between groups (VAS: p&gt;0.05). However, Group A showed significantly better oral health-related quality of life, as evidenced by lower OHIP-14 total scores (15.88±5.19) compared to Group B (18.12±5.09; p&lt;0.05).</div></div><div><h3>Conclusions</h3><div>Repeated PDT-assisted SRP enhances short-term soft tissue healing in Class II FI sites, modulates inflammation-related cytokines and subgingival microbiota, and reduces psychological discomfort without prolonging perceived treatment pain, duration or fatigue.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104629"},"PeriodicalIF":3.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of 5-aminolevulinic acid photodynamic therapy combined with microneedling for vulvar lichen sclerosus","authors":"Cuirong Xiao,&nbsp;Xiukuan Xu,&nbsp;Yayan Lin,&nbsp;Hong Kang,&nbsp;Honghui Zhang","doi":"10.1016/j.pdpdt.2025.104623","DOIUrl":"10.1016/j.pdpdt.2025.104623","url":null,"abstract":"<div><h3>Background</h3><div>Vulvar lichen sclerosus (VLS) is a chronic inflammatory dermatosis with limited therapeutic options for refractory or recurrent cases. This study aimed to evaluate the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with microneedling in VLS management.</div></div><div><h3>Methods</h3><div>Sixty-four VLS patients (diagnosed from January 2019 to December 2023) underwent ALA-PDT (incubation: 3 hours; irradiation: 635 nm, 100 mW/cm²) combined with microneedling (0.5 mm depth) every 2 weeks for 6 sessions. Outcomes included modified mLSSI score, ISSVD severity grading, Dermatology Life Quality Index (DLQI), dyspareunia Visual Analog Scale (VAS), adverse events, and 6-month recurrence rates.</div></div><div><h3>Results</h3><div>At 12 weeks, the total efficacy rate reached 92.19 % (59/64). mLSSI scores significantly decreased from 9.07±2.32 to 2.42±1.79 (<em>P</em> &lt; 0.001), with erosion/fissure improvement being most pronounced (86.29 % reduction). ISSVD grading showed complete resolution of severe cases (baseline: 85.94 % vs. 0 % post-treatment), with 90.63 % downgraded to mild. Subgroup analysis revealed superior outcomes in patients with disease duration &lt;1 year (baseline mLSSI: 7.68±2.29 vs. 9.97±1.87 in a long-duration group; <em>t</em> = 4.382, <em>P</em> &lt; 0.0001), particularly in skin texture recovery (90.59 % vs. 83.72 %). DLQI scores decreased by 73.74 % (15.04±2.80 to 3.95±2.02), and 88.89 % (24/27) of patients reported dyspareunia relief (VAS: 5.64±2.58 to 1.50±1.63). Recurrence occurred in 21.88 % (14/64) at 6 months, with no symptom exacerbation (<em>P</em> &gt; 0.05). Only 5 cases (7.81 %) experienced transient erythema, and no severe adverse events were observed.</div></div><div><h3>Conclusion</h3><div>ALA-PDT combined with microneedling achieves rapid and sustained symptom remission, improves quality of life, and demonstrates excellent safety in refractory VLS. Early intervention (disease duration &lt;1 year) correlates with superior therapeutic outcomes. This combination therapy represents a promising strategy for PDT-enhanced VLS management.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104623"},"PeriodicalIF":3.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography angiography study on retinochoroidal thickness and blood flow changes after posterior scleral reinforcement surgery","authors":"Yongqi Mao ,&nbsp;Hao Chen ,&nbsp;Yunhua Tang ,&nbsp;Haoming Geng ,&nbsp;Fuwen Zhang","doi":"10.1016/j.pdpdt.2025.104628","DOIUrl":"10.1016/j.pdpdt.2025.104628","url":null,"abstract":"<div><h3>Purpose</h3><div>Based on optical coherence tomography angiography (OCTA), we investigate the effects of posterior scleral reinforcement surgery on the fundus structure and function in patients with high myopia.</div></div><div><h3>Methods</h3><div>Retrospective clinical study. Forty cases (41eyes) of high myopia patients who underwent posterior scleral reinforcement surgery at Chengdu University of Traditional Chinese Medicine Affiliated Silver Eye Hospital from January 2022 to January 2025 were selected. Follow-up periods included postoperative 3 months, 6 months, and 1 year. Key indicators before and after surgery were compared, including best-corrected visual acuity (BCVA), axial length (AL), spherical equivalent (SE), retinal thickness (RT), choroidal thickness (CT), and Superficial retinal capillary plexus density (SCP), deep retinal capillary plexus density (DCP), choroidal vascularity index (CVI), choroidal stromal vascularity index (CSI).</div></div><div><h3>Results</h3><div>The study included 40 patients (41 eyes), comprising 9 male patients (9 eyes) and 31 female patients (32 eyes), with a mean age of 42.05 ± 18.71 years.At the last follow-up, patients showed significantly shortened AL (<em>P</em> &lt; 0.001), significantly improved BCVA (<em>P</em> &lt; 0.05), and significantly increased CT (<em>P</em> &lt; 0.05).SCP also exhibited significant postoperative increases (<em>P</em> &lt; 0.05). Additionally,CVI and CSI showed significant postoperative elevation (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This study demonstrates that posterior scleral reinforcement achieves axial stabilization through mechanical reinforcement, mitigates vitreous traction forces on the retina and choroid, enhances visual acuity, improves choroidoretinal microcirculation, and optimizes fundus architecture.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104628"},"PeriodicalIF":3.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro effects of laser-activated irrigation methods on apical extrusion of indocyanine green mediated photodynamic therapy","authors":"Behnam Bolhari ,&nbsp;Naghmeh Meraji ,&nbsp;Rahim Seddighi ,&nbsp;Yashar Safaraei ,&nbsp;Nasim Chiniforush","doi":"10.1016/j.pdpdt.2025.104626","DOIUrl":"10.1016/j.pdpdt.2025.104626","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to compare the effects of different laser-activated irrigation (LAI) methods on apical extrusion of indocyanine green (ICG).</div></div><div><h3>Materials and Methods</h3><div>In this in vitro study, 40 extracted single-canal premolars were instrumented and randomly assigned to 4 groups (<em>n</em> = 10) of (I) ICG (1 mg/mL) + photon-induced photoacoustic streaming (PIPS) with 2940 nm erbium laser, 20 mJ energy, and 50 µs pulse width for 30 s, (II) ICG + shockwave enhanced emission photoacoustic streaming (SWEEPS) with 2940 nm erbium laser with 20 mJ energy, and 50 µs pulse width (two 25 µs pulse widths) for 30 s, (III) ICG + 810 nm diode laser with 250 mW power for 30 s, and (IV) ICG without activation. Photoluminescence (PL) was used to quantify the ICG volume extruded through the apex, and determine the excitation wavelength of the ICG samples. To calibrate the PL results, one random ICG sample underwent inductively-coupled plasma (ICP) test to quantify the sulfur content of the extruded ICG. Considering the chemical formulation of ICG, the concentration of extruded ICG was calculated accordingly. Data were analyzed by one-way ANOVA (alpha=0.05).</div></div><div><h3>Results</h3><div>The best spectrum was obtained at 390 nm excitation wavelength with 700 V voltage and slit number=10. The study groups had no significant difference in the concentration of apically extruded ICG (<em>P</em> = 0.611).</div></div><div><h3>Conclusion</h3><div>The tested LAI protocols had no significant difference with each other or with the no activation protocol regarding the apical extrusion of ICG.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104626"},"PeriodicalIF":3.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear and non-linear association of chronic kidney disease with retina and choroid vessel density in diabetes: a prospective study","authors":"Lijian Fang ,&nbsp;Ruiheng Zhang ,&nbsp;Suoqing Zhuang ,&nbsp;Lei Wang ,&nbsp;Qiuping Wang ,&nbsp;Yong Huang ,&nbsp;Mingli Wang ,&nbsp;Yu Feng ,&nbsp;Min Xiao ,&nbsp;Chunyuan Zhou ,&nbsp;Lili Wu ,&nbsp;Sihan Zhang ,&nbsp;Lili Xue ,&nbsp;Tong Tian ,&nbsp;Yuanyuan Li ,&nbsp;Bing Cao ,&nbsp;Huaiyu Hao","doi":"10.1016/j.pdpdt.2025.104625","DOIUrl":"10.1016/j.pdpdt.2025.104625","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the association of retinal and choroidal vessel density with renal function using optical coherence tomographic angiography (OCTA).</div></div><div><h3>Method</h3><div>The present study prospectively recruited consecutive diabetes patients admitted to Beijing Liangxiang Hospital from October 2023 to March 2024. All participants underwent comprehensive ophthalmologic examinations and laboratory analysis at the first visit. Quantitative parameters of OCTA scans included retinal superficial vascular complex (SVC) and deep vascular complex (DVC) vessel densities, and choriocapillaris flow deficits (CCFD%).</div></div><div><h3>Results</h3><div>A total of 85 patients were included in the present study. After adjusting for severity of diabetic retinopathy and other confounding factors, every 1 % increased SVC within in ETDRS grid was associated with reduced incidence of CKD (OR=0.86 95 %CI:[0.73–1.01]), decreased urine albumin-to-creatinine ratio (ACR, coefficient=-0.65, 95 %CI:[-1.22, -0.08]), and increased eGFR (coefficient=1.55, 95 %CI:[0.14, 2.96]). Every 1 % increased CCFD% was significantly associated with increased incidence of CKD (OR=1.72, 95 %CI:[1.14–2.58]) and decrease eGFR (coefficient=-6.47, 95 %CI:[-9.68, -3.26]). Non-linear regression revealed that SVC vessel density was associated with eGFR among patients with advanced retinal microvasculature damage.</div></div><div><h3>Conclusions</h3><div>Retina and choroid blood flow were associated with the onset and severity of CKD. Decreased SVC and decreased CCFD% can be used for non-invasively screening CKD in diabetes patients.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104625"},"PeriodicalIF":3.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Raman spectroscopy assisted diagnosis and photodynamic therapy efficacy evaluation of actinic keratosis: Case report","authors":"Rongyi Zhu ,&nbsp;Shiyi Yang ,&nbsp;Na Yu ,&nbsp;Rongjun Zhang ,&nbsp;Minfeng Wu","doi":"10.1016/j.pdpdt.2025.104624","DOIUrl":"10.1016/j.pdpdt.2025.104624","url":null,"abstract":"<div><div>Actinic keratosis (AK), a precancerous skin lesion with malignant potential, demands timely diagnosis and effective treatment monitoring. Aminolevulinic acid photodynamic therapy (ALA-PDT) is the recommended treatment for AK, but there is currently a lack of methods to evaluate the effectiveness of treatment. Raman spectroscopy might be a promising tool for non-invasive diagnosis of AK and dynamic detection of PDT efficacy. This article reports a 77-year-old female patient with AK who received Raman spectroscopy detection and successful PDT. Utilizing a portable Raman spectrometer, distinct spectral features were identified: Raman band at 1688 cm⁻¹, attributed to elastin accumulation in AK lesions, and Raman band at 1615 cm⁻¹, associated with tyrosine, a melanin precursor. The patient underwent three sessions of ALA-PDT and Raman spectra were acquired after each session to reveal progressive changes in peak intensities. The findings demonstrate Raman spectroscopy’s dual potential: non-invasive diagnosis via elastin-related biomarkers and real-time efficacy evaluation of PDT through tyrosine-associated spectral changes, offering molecular specificity and dynamic monitoring without invasive procedures.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104624"},"PeriodicalIF":3.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}