Photodiagnosis and Photodynamic Therapy最新文献

{"title":"A meta-analysis of surgical margin status and prognosis after precise resection of liver cancer using fluorescence imaging-guided surgery","authors":"Fang Xie ,&nbsp;Qian Zhang ,&nbsp;Yuming Jia ,&nbsp;Kaijian Lei ,&nbsp;Hongru Yu ,&nbsp;Wei Zhang ,&nbsp;Li Li ,&nbsp;Daohong Kan","doi":"10.1016/j.pdpdt.2025.104663","DOIUrl":"10.1016/j.pdpdt.2025.104663","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study is to evaluate the value of intraoperative fluorescence imaging in assisting tumor localization and margin delineation during liver resection surgery, with the goal of improving the negative surgical margin rate and overall margin status.</div></div><div><h3>Methods</h3><div>A systematic search was conducted in the PubMed, Web of Science, Embase, and Cochrane Library databases for studies on the use of fluorescence imaging to aid in tumor localization and margin detection in liver cancer published between their inception and March 2025. After quality assessment of the included studies, a meta-analysis was performed using the STATA/SE 12.0 statistical software.</div></div><div><h3>Results</h3><div>A total of 10 studies comprising 1097 patients were included in this meta-analysis. Compared to conventional liver resection, fluorescence-guided hepatectomy significantly increased the R0 resection rate [Odds ratio (OR) = 2.51, 95 % confidence intervals (CI): 1.65, 3.81, <em>P</em> = 0.000], with similar results observed in subgroup analyses. In addition, the fluorescence-guided hepatectomy group showed significantly less intraoperative blood loss [Weighted mean differences (WMD) = -100.53, 95 % CI:171.38, -29.68, <em>P</em> = 0.005]. However, no statistically significant differences were observed between the two groups in terms of margin distance, operative time, intraoperative transfusion, hospital stay, or overall complication rate.</div></div><div><h3>Conclusion</h3><div>Fluorescence-guided hepatectomy can effectively increase the R0 resection rate and may contribute to reducing postoperative recurrence of liver cancer. However, further multicenter randomized controlled trials with larger sample sizes are needed to validate its impact on margin distance, operative time, intraoperative transfusion, hospital stay, and complication rates.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104663"},"PeriodicalIF":3.1,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"InnovEyes photodiagnosis of corneal parameters and photoablation in LASIK: a review of literature","authors":"Yuen Tsing Adeline Ho ,&nbsp;Sunny Chi Lik Au","doi":"10.1016/j.pdpdt.2025.104661","DOIUrl":"10.1016/j.pdpdt.2025.104661","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104661"},"PeriodicalIF":3.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of early inner retinal layer changes in hydroxychloroquine users without evident retinopathy: A comparative study","authors":"Mahmut Asfuroğlu ,&nbsp;Ahmet Selçuk Çobanoğlu ,&nbsp;Yonca Asfuroğlu ,&nbsp;Cenk Zeki Fikret ,&nbsp;Nil İrem Uçgun Zeki Fikret","doi":"10.1016/j.pdpdt.2025.104662","DOIUrl":"10.1016/j.pdpdt.2025.104662","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to examine alterations in the macular ganglion cell complex (GCC), peripapillary retinal nerve fiber layer (RNFL), and macular vasculature prior to the manifestation of evident outer retinal toxicity in patients receiving hydroxychloroquine (HCQ).</div></div><div><h3>Material-Method</h3><div>The present comparative cross-sectional study included 42 patients with no evident retinopathy who were taking &lt;5 mg/kg HCQ for rheumatoid arthritis and 41 age-matched healthy subjects. Both groups were analyzed using swept-source optical coherence tomography (SS-OCT), comprising macular GCC and peripapillary RNFL. Macular vessel density (MVD) analysis was conducted using OCT angiography.</div></div><div><h3>Results</h3><div>The superior (<em>p</em> = 0.04), inferior (<em>p</em> = 0.01), and total GCC (<em>p</em> = 0.02) values were significantly lower in the study group than in the control group. However, the RNFL and MVD measurements demonstrated no statistically significant disparities in any of the quadrants between the two groups (<em>p</em> &gt; 0.05). The subgroup analysis revealed that patients who had received HCQ for ≥ 8 years demonstrated significantly lower superior, inferior, and total GCC thickness, in addition to thinner RNFL values in superior quadrants when compared to patients who had received HCQ for a period of &lt; 8 years and the control group.</div></div><div><h3>Conclusion</h3><div>The present study demonstrated that after eight years of HCQ use at recommended doses, significant thinning of the inner retinal layers was observed in eyes exhibiting no evident retinal toxicity. It may be beneficial to include an inner retinal layer assessment in individuals chronically using HCQ as part of a comprehensive ophthalmic screening process.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104662"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical 5-aminolevulinic acid photodynamic therapy for actinic keratosis increases skin elasticity and hydration","authors":"Li-Yi Chan ,&nbsp;Wei-En Wang ,&nbsp;Ro‑Wei Wu ,&nbsp;Jen-Hung Wang ,&nbsp;Pin-Yu Chen ,&nbsp;Chung‑Hsing Chang","doi":"10.1016/j.pdpdt.2025.104660","DOIUrl":"10.1016/j.pdpdt.2025.104660","url":null,"abstract":"<div><h3>Introduction</h3><div>Photodynamic therapy (PDT) is a field-directed strategy to manage multiple actinic keratosis (AK) lesions. During the course of PDT, AK has been found to regress; meantime, lentigines, roughness, and fine lines advance on the photoaged skin. In this study, we adopted a noninvasive biophysical platform MPA580 to analyze skin indices of aging, including elasticity, hydration, sebum, transepidermal water loss (TEWL), melanin, erythema, and pH value. We aimed to provide additional quantitative evidence showing that PDT, used in a standard therapeutic regimen that is known to ameliorate AK, can also have significant anti-photoaging effects in a population of older adults with type III-IV skin.</div></div><div><h3>Materials and methods</h3><div>Eighteen volunteers, 12 males and 6 females, mean age 74 years, histopathologically diagnosed with AK were included. Two sessions of PDT were conducted with a 4-week interval. The photosensitizer, 10 % aminolevulinic acid (Ameluz®) was applied to the whole face with occlusion for 2 h, and the whole face was irradiated with a 630-nm light source for 26 min at a mean light dose of 78 J/cm². Skin biophysical assessments were sequentially performed at four time points. The first was 1 day before the first PDT, the second was 4 weeks after the baseline, the third was 8 weeks after the baseline, and the 4th was 12 weeks after the baseline.</div></div><div><h3>Results</h3><div>Cheek elasticity significantly improved at weeks 4th and 8th (<em>p</em> = 0.006 and 0.002, respectively). Cheek hydration significantly increased at the 4th week (<em>p</em> = 0.018). No significant changes were observed in terms of cheek TEWL, melanin, erythema, sebum and pH values, and all parameters on the forehead and nose tip.</div></div><div><h3>Discussion</h3><div>Topical PDT improves skin hydration and elasticity. It is a promising strategy for photorejuvenation for people aged &gt;70 years. Future studies using large cohorts and long follow-up duration should be conducted to validate our results.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104660"},"PeriodicalIF":3.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Antimicrobial Photodynamic Inactivation of Pseudomonas aeruginosa Persister Cells and Biofilms” [Photodiagnosis and Photodynamic Therapy 51 (2025) 104456]","authors":"Mona Mahmoud ,&nbsp;Peter Richter ,&nbsp;Philipp Arnold ,&nbsp;Michael Lebert ,&nbsp;Andreas Burkovski","doi":"10.1016/j.pdpdt.2025.104508","DOIUrl":"10.1016/j.pdpdt.2025.104508","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104508"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative analysis of retinal and choroidal microvascular changes after endonasal endoscopic pituitary adenoma resection: An OCTA study","authors":"Liu Chen ,&nbsp;Linhao Wang ,&nbsp;Yonggang Wu ,&nbsp;Ning Li ,&nbsp;Lin Lin ,&nbsp;Xiaolong Li ,&nbsp;Yunxian Gao ,&nbsp;Yong Zhao","doi":"10.1016/j.pdpdt.2025.104639","DOIUrl":"10.1016/j.pdpdt.2025.104639","url":null,"abstract":"<div><h3>Background</h3><div>This study used swept-source optical coherence tomography angiography (SS-OCTA) to compare retinal and choroidal vascular parameter changes before and after transsphenoidal surgery in pituitary adenoma (PA) patients, and to compare these changes with healthy controls, in order to evaluate its predictive value for visual recovery and determine the optimal timing for surgery.</div></div><div><h3>Methods</h3><div>23 PA patients (46 eyes) and 25 healthy volunteers (50 eyes) were included. The PA group was followed up at 1 week and 1 month postoperatively. Retinal and choroidal parameters in the macula(M) area and optic nerve head(ONH) area were assessed, including thickness(T), volume(V), vascular flow density (VFD), foveal avascular zone (FAZ), choroidal vascular volume (CVV) and choroidal vascular index (CVI).</div></div><div><h3>Results</h3><div>Comparison of retinal and choroidal morphology and blood flow between the case group and the control group showed significant increases in the deep capillary plexus (DCP) thickness and volume in the macula. The superficial capillary plexus (SCP) thickness, volume, large and medium choroidal vessels (LMCV) CVI (<em>p</em> = 0.032) in the optic disc area, as well as all indicators of the FAZ were significantly reduced. Compared to preoperative values, a week postoperatively, SCP-T and SCP-V in the optic disc area, and DCP FAZ perimeter all significantly decreased, while SCP VFD in the foveal avascular zone within 300 μm (FAZ300) significantly increased (<em>p</em> = 0.047). Compared to preoperative values, 1 month postoperatively, LMCV choroidal matrix density (CSI), CVI (<em>p</em> = 0.022) and DCP-T in the optic nerve area significantly decreased, while SCP-FAZ300 significantly increased (<em>p</em> = 0.0282). Tumor size was the most important factor affecting retinal and choroidal parameters.</div></div><div><h3>Conclusion</h3><div>The SCP-T, CSI, CVI, and other parameters in PA patients were significantly lower compared to healthy controls. These parameters further decreased after decompression surgery, likely due to secondary changes from optic nerve atrophy caused by tumor compression. The continulous improvement of SCP foveal avascular zone within 300 μm(FAZ300) may be related to the recovery of blood flow after the decompression, as the macular cells remain intact. These parameters—SCP-FAZ300, LMCV-CVI/CSI, and SCP-ONH T/V—collectively quantify postoperative visual acuity(VA)and visual field(VF) outcomes and guide surgical timing selection.These findings suggest that PA patients require earlier screening and treatment, and OCTA can serve as an optimal non-invasive evaluation tool.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104639"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Correlation of retinal curvature with ocular biometry in patients with myopia” [Photodiagnosis and Photodynamic Therapy 52 (2025) 104505]","authors":"Guo-Ren Xu ,&nbsp;Ming Yan ,&nbsp;Zhen Huang ,&nbsp;Ya Ye ,&nbsp;Yan-Ping Song","doi":"10.1016/j.pdpdt.2025.104605","DOIUrl":"10.1016/j.pdpdt.2025.104605","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104605"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “ALA-PDT promotes IL-1β secretion from human SZ95 sebocytes via activation of the NLRP3 inflammasome” [Photodiagnosis and Photodynamic Therapy 46 (2024) 104007]","authors":"Jian Zhang ,&nbsp;Yufeng Chang ,&nbsp;Suqing Liu ,&nbsp;Jiang Tuo ,&nbsp;Zhongyi Xu ,&nbsp;Jiayi Ying ,&nbsp;Yijian Zhu ,&nbsp;Zhengzhou Shi ,&nbsp;Christos C. Zouboulis ,&nbsp;Min Jiang ,&nbsp;Qianqian Wang ,&nbsp;Leihong Xiang","doi":"10.1016/j.pdpdt.2025.104607","DOIUrl":"10.1016/j.pdpdt.2025.104607","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104607"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Comparative analysis of optic disc and macular microvasculature in children with anisometropic amblyopia before and after treatment” [Photodiagnosis and Photodynamic Therapy volume 52 (2025) 1-10]","authors":"Jia-Hao Li ,&nbsp;Jian Zhao ,&nbsp;Chang Won Park ,&nbsp;Chen-Yu Yang ,&nbsp;Jia-Yu Ma ,&nbsp;Jing Wang ,&nbsp;Ying-Jun Li","doi":"10.1016/j.pdpdt.2025.104601","DOIUrl":"10.1016/j.pdpdt.2025.104601","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104601"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Inhibition of efflux pump encoding genes and biofilm formation by sub-lethal photodynamic therapy in methicillin susceptible and resistant Staphylococcus aureus” [Photodiagnosis and Photodynamic Therapy 102900 (2022) 102900]","authors":"Yanlan Yu ,&nbsp;Yan Zhao ,&nbsp;Yaxiong He ,&nbsp;Jiayin Pang ,&nbsp;Zengjun Yang ,&nbsp;Mengxue Zheng ,&nbsp;Rui Yin","doi":"10.1016/j.pdpdt.2025.104492","DOIUrl":"10.1016/j.pdpdt.2025.104492","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104492"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}