Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Corrigendum to “Evaluation of topical photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA) for cervical intraepithelial neoplasia with human papillomavirus (HPV) infection: a retrospective comparative study versus loop electrosurgical excision procedure (LEEP)” [Photodiagnosis Photodyn Ther. (2025);54:104697]","authors":"Jue Li , Ying Huang , Jinxin Tao , Hangli Yang , Hua Zhu","doi":"10.1016/j.pdpdt.2025.104764","DOIUrl":"10.1016/j.pdpdt.2025.104764","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104764"},"PeriodicalIF":2.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations between variability of preoperative ocular biometric measurements and accuracy of intraocular lens power calculation","authors":"Zhenqiang Lin ,&nbsp;Ling Jin ,&nbsp;Yue Wu ,&nbsp;Wenxuan Wang ,&nbsp;Ying Tang ,&nbsp;Yijun Hu ,&nbsp;Duanrong Cao","doi":"10.1016/j.pdpdt.2025.105210","DOIUrl":"10.1016/j.pdpdt.2025.105210","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the relationship between variability of preoperative ocular biometric measurements and the accuracy of intraocular lens (IOL) power calculation.</div></div><div><h3>Methods</h3><div>This retrospective study included cataract patients who underwent surgery at the People’s Hospital of Baoan Shenzhen from January 2022 to December 2024. Preoperative ocular biometric parameters were measured using the Lenstar LS-900, and the coefficients of variation (CV) of corneal curvature (K1-CV, K2-CV), axial length (AL-CV), anterior chamber depth (ACD-CV) were calculated. Intented residual refractive error (IRRE) was recorded. Postoperative spherical equivalent (SE), prediction error (PE = SE - IRRE), and absolute prediction error (APE = |PE|) were evaluated at one month postoperatively. The mean, median and interquartile range of PE and APE were calculated. Patients were divided into two groups based on the number of valid axial length measurements (Group 1: &lt;3; Group 2: ≥3). Differences in age, sex, preoperative visual acuity (LogMAR VA), K1-CV, K2-CV, AL-CV, ACD-CV, PE, and APE were compared between the two groups. Spearman correlation was used to assess the relationship between biometric variability (K1-CV, K2-CV, AL-CV, ACD-CV) and refractive outcomes (PE and APE).</div></div><div><h3>Results</h3><div>A total of 118 eyes were included (Group 1: 44 eyes; Group 2: 74 eyes). Preoperative LogMAR VA was significantly worse in Group 1 than those in Group 2 (0.84 vs. 0.46, <em>p</em> &lt; 0.001), but no significant differences were observed in age, sex, ACD, AL, mean keratometry (Km), PE, or APE between the two groups. Group 1 showed a mean PE of -0.13 and mean APE of 0.61, with 27.03 %, 39.19 %, and 50.0 % of eyes within ±0.25 D, ±0.50 D, and ±1.00 D of target refraction, respectively. In comparison, Group 2 demonstrated a lower mean PE (-1.80) and APE (0.48), and higher proportions of eyes within ±1.00 D (89.19 %). Variability in biometric parameters did not differ between the two groups (<em>p</em> ≥ 0.05). A weak correlation was found between preoperative VA and APE in Group 1 (<em>r</em> = 0.314, <em>p</em> = 0.038), but no significant correlations were detected between variability in biometric parameters with PE or APE.</div></div><div><h3>Conclusions</h3><div>The number of valid axial length measurements did not significantly affect preoperative ocular biometric variability or IOL power calculation accuracy in patients with cataract. Patients with fewer valid measurements (&lt;3) had worse preoperative VA, which was weakly correlated with APE.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105210"},"PeriodicalIF":2.6,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cavity hyperreflective-content and septum's motion artifact in optical coherence tomography angiography","authors":"Shaochi Zhang ,&nbsp;Yunkao Zeng ,&nbsp;Feng Wen ,&nbsp;Xiongze Zhang","doi":"10.1016/j.pdpdt.2025.105211","DOIUrl":"10.1016/j.pdpdt.2025.105211","url":null,"abstract":"<div><h3>Purpose</h3><div>To characterize the cavity hyperreflective-content and septum's motion artifact (CHASMA) in en face optical coherence tomography angiography (OCTA) across multiple ocular fundus abnormalities.</div></div><div><h3>Methods</h3><div>This was a cross-sectional, observational study. Subjects with extravascular OCTA signals arising from the cavity’s hyperreflective-content and/or septum were enrolled. Characteristics of en face OCTA images and corresponding cross-sectional optical coherence tomography (OCT) images were evaluated. CHASMA was classified according to anatomic location.</div></div><div><h3>Results</h3><div>The images of 25 eyes from 25 subjects were analyzed. CHASMA was identified in particles within the vitreous cavity, intraretinal cyst, subretinal space and the pigment epithelial detachment (PED) cavities. The regions of CHASMA in all included OCTA images were associated with hyperreflective cavity content and/or intercavity septa on the corresponding structural OCT. CHASMA was classified as vitreous, intraretinal, subretinal and PED-CHASMA according to the anatomic locations. Fourteen eyes with vitreous opacities secondary to vitreous hemorrhage, vitreous floater were classified as vitreous CHASMA. Six eyes with cystoid macular edema and 1eye with sub‐internal limiting membrane hemorrhage were classified as intraretinal CHASMA. Two eyes with subretinal hemorrhage or bacillary detachment were classify as subretinal CHASMA and 2 eyes with hemorrhagic PED were classified as PED CHASMA.</div></div><div><h3>Conclusions</h3><div>The cavities at different fundus levels may allow for macroscopic motion of the contents and intercavity septa, producing various motion artifacts. These motion artifacts are termed CHASMA and cautions should be taken when interpreting en face OCTA images.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 105211"},"PeriodicalIF":2.6,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of photodynamic therapy and estrogen cream for menopause women with cervical low-grade squamous intraepithelial lesion with human papillomavirus infection","authors":"Wendi Yang ,&nbsp;Guoqing Jiang ,&nbsp;Yunduo Liu ,&nbsp;Lijing Zhang ,&nbsp;Yajun Li","doi":"10.1016/j.pdpdt.2025.104791","DOIUrl":"10.1016/j.pdpdt.2025.104791","url":null,"abstract":"<div><h3>Background</h3><div>In menopausal women, decreased estrogen levels lead to genital tract mucosal atrophy and reduced mucosal immune function. Low-grade squamous intraepithelial lesions (LSIL) associated with persistent or newly acquired high-risk HPV infection may progress silently to high-grade squamous intraepithelial lesions (HSIL) and eventually cervical cancer.</div></div><div><h3>Objective</h3><div><strong>:</strong> This study aimed to evaluate the efficacy and safety of photodynamic therapy combined with estrogen in the treatment of menopausal women with LSIL and high-risk HPV infection.</div></div><div><h3>Methods</h3><div>A retrospective controlled study was conducted to compare LSIL regression and HPV clearance among three treatment groups: photodynamic therapy plus estrogen, interferon gel plus estrogen, and estrogen alone. Therapeutic outcomes were assessed using ThinPrep cytology (TCT), HPV testing, and colposcopic pathology at 3, 6, and 12 months post-treatment.</div></div><div><h3>Results</h3><div>The rates of LSIL regression and HPV clearance in the photodynamic therapy plus estrogen group were significantly higher than those in both the interferon gel plus estrogen group and the estrogen-alone group at 3, 6, and 12 months (<em>p</em> &lt; 0.05). Furthermore, the interferon gel plus estrogen group showed improved outcomes compared to estrogen alone, with statistically significant differences (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Photodynamic therapy combined with estrogen cream is an effective and safe treatment approach for menopausal women with LSIL and high-risk HPV infection.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104791"},"PeriodicalIF":2.6,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal imaging and artificial intelligence: A systematic review and meta-analysis of diagnostic techniques for neurodegenerative diseases","authors":"Zohreh Ganji ,&nbsp;Farzaneh Nikparast ,&nbsp;Naser Shoeibi ,&nbsp;Ali Shoeibi ,&nbsp;Hoda Zare ,&nbsp;Nooshin Akbari Sharak","doi":"10.1016/j.pdpdt.2025.104788","DOIUrl":"10.1016/j.pdpdt.2025.104788","url":null,"abstract":"<div><h3>Background</h3><div>Artificial intelligence (AI)–driven analysis of retinal images holds promise for noninvasive, early detection of neurodegenerative disorders. We conducted a prospectively registered systematic review and meta‑analysis to quantify diagnostic accuracy of AI‑assisted retinal imaging across Alzheimer’s disease (AD), Parkinson’s disease (PD), and related conditions.</div></div><div><h3>Methods</h3><div>We searched six databases for studies (2010–2024) employing AI/ML models for binary classification of neurodegenerative disease versus healthy controls. Risk of bias was assessed using QUADAS-2. We extracted pooled area under the receiver operating characteristic curve (AUC) with 95 % confidence intervals (CIs), heterogeneity statistics, and participant numbers. Certainty of evidence was graded using GRADE criteria.</div></div><div><h3>Results</h3><div>Our analysis included ten studies (seven on AD, four on PD; 496 patients, 441 patients, and 36,990 healthy controls). The overall pooled AUC was 0.73 (95 % CI, 0.69–0.77; I²=78 %). Subgroup analyses showed an AUC of 0.72 for AD and 0.70 for PD. QUADAS-2 assessments indicated low-to-moderate risk of bias, with patient selection variability being a key concern. GRADE evaluations showed moderate to high certainty in the evidence.</div></div><div><h3>Conclusions</h3><div>AI‑assisted retinal imaging demonstrates consistent, moderate accuracy for early detection of AD and PD. Future research should standardize imaging protocols and patient selection criteria, and pursue large-scale, prospective validation.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104788"},"PeriodicalIF":2.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial verrucous epidermal nevus with pruritus: Successfully treated with photodynamic therapy","authors":"Qiying Zhang ,&nbsp;Kaili Chen ,&nbsp;Xuefeng Fu ,&nbsp;Meiyan Wang ,&nbsp;Qi Tu ,&nbsp;Yanfei Zhang","doi":"10.1016/j.pdpdt.2025.104785","DOIUrl":"10.1016/j.pdpdt.2025.104785","url":null,"abstract":"<div><div>Verrucous epidermal nevus (VEN) is uncommon and is typically present at birth. The disorder is essentially cosmetic and is found more often in females which features were brown and skin-colored verrucous papules or plaques distributed linearly along Blaschko’s lines. VEN on the face often adversely affect the patient’s self-esteem. While complete excision of the lesion is curative, it may leave disfiguring scars. The treatment of VEN on the face is challenging.</div><div>We report a case of 28-year-old woman who presented with a wart-like lesion on the left side of her face which was accompanied by pruritus. Dermoscopy and histopathological examination were performed and the patient was diagnosed with VEN. She was treated with the carbon dioxide(CO2) laser and aminolevulinate photodynamic therapy (ALA-PDT). The carbon dioxide laser was applied to remove the hypertrophic lesion and enable the transdermal absorption of aminolevulinic acid. The first step was the topical application of a cream with 20 % ALA to the lesion, after which the area was sealed for three hours to block light before PDT treatment. Subsequent PDT treatment enhanced healing and reduced potential scarring. After 4 sessions of ALA-PDT, only slight elevation of the skin at the tumor site was observed, and the lesion could be concealed with makeup, thereby achieving a superior cosmetic effect. The patient experienced a significant reduction in psychological stress with marked alleviation of the pruritis. Therefore, we consider that ALA-PDT combined with CO2 laser is both safe and effective for treating facial verrucous epidermal nevus.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104785"},"PeriodicalIF":2.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the efficacy of photodynamic therapy in treating cervical lesions and HPV infections and its influencing factors","authors":"Xueliang Hu ,&nbsp;Xuewang Guo ,&nbsp;Jing Sha ,&nbsp;Yu Dou ,&nbsp;Hui Ma ,&nbsp;Honglin Li ,&nbsp;Yanying Xu","doi":"10.1016/j.pdpdt.2025.104786","DOIUrl":"10.1016/j.pdpdt.2025.104786","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy of photodynamic therapy (PDT) in patients with human papillomavirus (HPV) infection and cervical lesions, meanwhile factors influencing the efficacy of PDT were analyzed.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed on 110 patients with HPV infection and cervical lesions. All patients underwent HPV genotyping, ThinPrep Cytology Test (TCT), and pathological examination, the changes before and after PDT treatment for 6 months were analyzed. In evaluating the therapeutic effect, if HPV is completely eliminated or cervical lesions return to normal, it was counted in the negative conversion rate; If HPV is partially eliminated or cervical lesions are downgraded but not return to normal, it was counted in the effective rate. Meanwhile, patients were grouped according to HPV vaccination history, menopausal status, transformation zone type and previous HPV infection history, and the therapeutic effects of anti-HPV and cervical lesion were compared among different groups.</div></div><div><h3>Results</h3><div>After PDT, the negative conversion rate of HPV was 45.45 % with an effective rate of 64.54 %; the negative conversion rate of TCT was 63.51 % with an effective rate of 68.91 %; and the negative conversion rate of pathology was 72.22 % with an effective rate of 79.62 %. The HPV negative conversion rate (78.57 % vs. 35.36 %) and TCT negative conversion rate (83.33 % vs. 57.14 %) in the vaccinated population were significantly higher than those in the unvaccinated population (<em>p</em> &lt; 0.05). The non-menopausal population showed significantly higher TCT negative conversion rate (72.00 % vs. 45.83 %) and effective rate (78.00 % vs. 45.83 %), as well as pathological negative conversion rate (85.36 % vs. 30.76 %) and effective rate (87.80 % vs. 46.15 %) compared with the menopausal population (<em>p</em> &lt; 0.05). Patients with type Ⅰ and Ⅱ transformation zone (TZ) show significantly better outcomes than those with TZ3 in anti-HPV treatment and cervical lesion management (<em>p</em> &lt; 0.05). Patients without a history of HPV infection had significantly higher TCT negative conversion rate (73.33 % vs. 35.89 %) and effective rate (73.33 % vs. 46.15 %) than those with a previous infection history (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>PDT shows good therapeutic effects in both HPV infection and cervical lesions. In addition, better therapeutic effects are observed in populations with a history of HPV vaccination, non-menopausal populations, populations without previous HPV infection, and those with type Ⅰ or Ⅱ cervical transformation zones.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104786"},"PeriodicalIF":2.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of corneal biomechanical parameters and corneal thickness measured by Corvis ST and AS-OCT in progressive keratoconus treated by accelerated corneal cross-linking","authors":"Luanying Wei,&nbsp;Tiantian Qi,&nbsp;Lei Luo,&nbsp;Qiang Shi,&nbsp;Shengjian Mi,&nbsp;Cheng Pei","doi":"10.1016/j.pdpdt.2025.104783","DOIUrl":"10.1016/j.pdpdt.2025.104783","url":null,"abstract":"<div><h3>Purpose</h3><div>To explore the characteristics of corneal biomechanical parameters and corneal thickness in different corneal regions in progressive keratoconus treated by accelerated “epithelium off” cross-linking (A-CXL) surgery.</div></div><div><h3>Methods</h3><div>This is a retrospective study and is self-controlled before and after surgery. A total of 39 eyes of 25 patients with progressive keratoconus were recruited and treated by A-CXL. The corneal biomechanical parameters and corneal thickness were recorded at baseline, 1-month, 3-month, and 6-month after surgery. Besides, analysis of correlations was applied to explore the association between these two features.</div></div><div><h3>Results</h3><div>Most of the biomechanical parameters, corneal thickness of different areas, as well as visual acuity, curvature and higher-order aberrations (HOAs), showed significant changes at 1 month and 3 months after surgery. Then gradually became stable and close to baseline values at 6 months postoperative. The epithelium became thicker earlier (after 1 month). The central and inferior areas of corneal stroma and the whole cornea were significantly thinnest at 3 months, other areas were thinnest at 1 month. Only several biomechanical parameters showed positive or negative correlations with corneal thickness, including the changes of them from baseline to different time after treatment.</div></div><div><h3>Conclusion</h3><div>The accelerated cross-linking not only has a significant effect, especially on the corneal central, inferotemporal, and inferonasal regions, which can prevent the progression of keratoconus. But also, can maintain the integrity of the epithelium, achieve corneal biomechanical recovery and improve visual acuity, curvature and HOAs in the short term at the same time.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104783"},"PeriodicalIF":2.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The photodynamic antimicrobial chemotherapy activities of azaBODIPY dyes and their gold nanoparticle conjugates","authors":"Temlandvo M. Magwaza,&nbsp;Nthabeleng Molupe,&nbsp;Yolande I. Openda,&nbsp;John Mack,&nbsp;Tebello Nyokong","doi":"10.1016/j.pdpdt.2025.104781","DOIUrl":"10.1016/j.pdpdt.2025.104781","url":null,"abstract":"<div><div>This synthesis and photophysicochemical properties of two 2,6-diiodinated azaBODIPY dyes with thiomethylphenyl groups at the distal positions and phenyl (<strong>1</strong>) and naphthyl (<strong>2</strong>) rings at the proximal positions are reported. The dyes were conjugated to gold nanoparticles (<strong>1</strong>-AuNPs and <strong>2</strong>-AuNPs) to enhance their aqueous solubility for biomedical applications. Iodination at the 2,6-positions resulted in an enhancement of singlet oxygen generation, with singlet oxygen quantum yield (Φ_∆) values of 0.82 and 0.55 obtained in DMSO for <strong>1</strong> and <strong>2</strong>, respectively. The photodynamic antimicrobial chemotherapy (PACT) activities of the dyes were tested with a Thorlabs M660L3 light-emitting diode (LED) against <em>Staphylococcus aureus</em> after incubation at 5 µM. Conjugation to gold nanoparticles was found to significantly enhance the PACT activities against <em>Staphylococcus aureus</em>. Log₁₀ reduction values of 8.94 were obtained for <strong>1</strong>-AuNPs after 30 min irradiation (3.0 J.cm⁻²) and <strong>2</strong>-AuNPs after 60 min (6.0 J.cm⁻²).</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104781"},"PeriodicalIF":2.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic efficacy of highly aspherical lenslets combined with low-concentration atropine: A retrospective study","authors":"Guorui Hu ,&nbsp;Zhixing Xu ,&nbsp;Zhengyang Tao ,&nbsp;Zongyue Lv ,&nbsp;Weishan Li ,&nbsp;Zefeng Kang ,&nbsp;Hongwei Deng","doi":"10.1016/j.pdpdt.2025.104779","DOIUrl":"10.1016/j.pdpdt.2025.104779","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to evaluate the efficacy of 0.01 % atropine (AT), highly aspherical lenslets (HAL), and their combination in controlling myopia progression in children and adolescents.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted involving 144 children and adolescents aged 8 to 15 years who visited Shenzhen Eye Hospital between 2022 and 2024. Patients were categorized by refractive status into SE &gt; -2.00 D (-2.00D &lt; spherical equivalent [SE] ≤ -0.25D) and SE ≤ -2.00 D (SE ≤ -2.00D in at least one eye) groups. The SE &gt; -2.00 D group was further divided into AT, HAL, and HAL+AT subgroups, while the SE ≤ -2.00 D group was divided into HAL and HAL+AT subgroups. Data collected included best-corrected visual acuity, cycloplegic SE, and axial length. The Shapiro-Wilk test was used to assess normality. Baseline differences were analyzed with parametric and non-parametric tests. Generalized estimating equations (GEE) were applied to evaluate longitudinal SE changes across groups, followed by post hoc comparisons.</div></div><div><h3>Results</h3><div>In both the SE &gt; -2.00 D and SE ≤ -2.00 D groups, the final GEE model identified statistically significant differences based on treatment group, time, baseline average spherical equivalent of both eyes (SE-mean), and age (<em>p</em> &lt; 0.05). In the SE &gt; -2.00 D group, the HAL+AT group significantly slowed myopia progression by 0.338D compared to the AT group. The HAL group also significantly slowed myopia progression by 0.235D compared to the AT group. In the SE ≤ -2.00 D group, after adjusting for potential covariates, the HAL+AT group significantly slowed myopia progression by 0.247D compared to the HAL group.</div></div><div><h3>Conclusion</h3><div>Over one year, combining HAL with 0.01 % atropine effectively controlled myopia progression in children and adolescents with varying refractive statuses.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104779"},"PeriodicalIF":2.6,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}