Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Photodynamic therapy for long-term management of oral leukoplakia: A 10-year follow-up case report","authors":"Zhixin Yang,&nbsp;Jiongke Wang,&nbsp;Mingjia Hu,&nbsp;Xin Zeng,&nbsp;Tiannan Liu,&nbsp;Qianming Chen","doi":"10.1016/j.pdpdt.2025.105242","DOIUrl":"10.1016/j.pdpdt.2025.105242","url":null,"abstract":"<div><div>Oral leukoplakia (OLK) is a prevalent oral potentially malignant disorder. Long-term management of OLK poses significant clinical challenges due to its high recurrence rate and substantial risk of malignant transformation. Conventional therapies include topical and systemic pharmacotherapy, surgical treatment, and laser therapy. However, photodynamic therapy (PDT) offers distinct advantages such as minimal invasiveness, mild adverse effects, repeatability, and no negative impact on aesthetics or function. To date, the application of PDT in the long-term management of OLK has been rarely reported in the literature. In this case, a non-smoking female exhibited non-homogeneous leukoplakia located in the high-risk area of the ventral tongue, conferring substantial malignant transformation potential. A disease course timeline illustrates over 10 years of management encompassing 109 clinical encounters. The patient had poor response to pharmacological treatments and experienced postoperative recurrence after surgical intervention. However, after the introduction of PDT, the condition was effectively controlled. Analysis of the 25 PDT sessions administered to date revealed an efficacy rate of 92% for complete or partial regression. We have also summarized the methods and principles for the long-term management of OLK with PDT. Over more than 10 years of follow-up, this case has not developed malignant transformation, and the condition remains stable, highlighting the significant clinical value of PDT in the management of OLK.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105242"},"PeriodicalIF":2.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of clinical characteristics of multifocal electroretinogram and microperimetry in patients with high myopia","authors":"Xiaofan Yin ,&nbsp;Peiyan Shi ,&nbsp;Jinling Ge","doi":"10.1016/j.pdpdt.2025.105237","DOIUrl":"10.1016/j.pdpdt.2025.105237","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the role of microperimetry (MP) and multifocal electroretinogram (mfERG) in evaluating macular function in high myopia</div></div><div><h3>Methods</h3><div>From January to June 2025, data from 42 patients (76 eyes) undergoing both MP and mfERG at Jinan Mingshui Eye Hospital were retrospectively analyzed. The impact of axial length, atrophic macular degeneration (Atrophic, Tractional, Neovascular, ATN) grade, and age on the results was compared</div></div><div><h3>Results</h3><div>MP and mfERG results in pathological myopia were significantly lower than the normal range. Significant differences in light sensitivity and best-corrected visual acuity (BCVA) were found across different axial lengths, ATN grades, and age groups (<em>P</em> &lt; 0.05). For amplitude density, Ring3 and Ring4 showed significant differences among axial lengths (<em>P</em> &lt; 0.05), while Rings 1–5 exhibited significant differences among ATN grades and age groups (<em>P</em> &lt; 0.05). Further clarification is needed for latency differences among these variables</div></div><div><h3>Conclusion</h3><div>MP and mfERG are valuable tools for assessing macular function changes in high myopia.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105237"},"PeriodicalIF":2.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photocatalytic antimicrobial effect of titanium dioxide coated clear-aligners on Streptococcus mutans and evaluation the physico-mechanical characteristics","authors":"Maryam Pourhajibagher ,&nbsp;Rashin Bahrami ,&nbsp;Mohammadreza Moeininejad ,&nbsp;Roghayeh Ghorbanzadeh ,&nbsp;Abbas Bahador","doi":"10.1016/j.pdpdt.2025.105235","DOIUrl":"10.1016/j.pdpdt.2025.105235","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluated the photocatalytic antimicrobial effect of titanium dioxide (TiO₂)-coated clear aligners against <em>Streptococcus mutans</em> and assessed the impact of TiO₂ coating on surface microhardness and optical transparency.</div></div><div><h3>Materials and methods</h3><div>Clear aligner samples (10 × 10 × 2 mm) were coated with different concentrations of TiO₂ (1 %, 2 %, and 4 %) via submerging. Uniformity of particle distribution and surface microhardness were measured using scanning electron microscope (SEM) and Vickers hardness testing, respectively. Optical transparency was assessed via ultraviolet-visible spectrophotometry. After incubation in artificial saliva, samples were exposed to ultraviolet A (UVA) at 320 nm for 1 min with an energy density of 18.75 J/cm²). Biofilm inhibition was evaluated by crystal violet colorimetric assay, measuring optical density at 595 nm. Expression of <em>gtfB</em> gene was analyzed via quantitative real-time polymerase chain reaction.</div></div><div><h3>Results</h3><div>SEM images confirmed uniform nanoparticle distribution with no surface damage. The combination of TiO₂ coating and UVA exposure significantly reduced biofilm formation, with the 4 % TiO₂ group demonstrating the highest inhibitory effect compared to the control group (<em>P</em> &lt; 0.001). Additionally, expression of the <em>gtfB</em> gene was significantly downregulated in this group (–6.35 ± 0.30). Surface microhardness showed a non-significant increase with higher TiO₂ concentrations, suggesting enhanced wear resistance without compromising material properties. However, the 4 % TiO₂ coating resulted in a significant reduction in optical transparency compared to other groups (<em>P</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>While 4 % TiO₂ coating with UVA activation achieved the strongest antibiofilm effect, it compromised optical transparency. The 2 % TiO₂ coating preserved aesthetics and still provided substantial antimicrobial activity, making it the more practical clinical option.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105235"},"PeriodicalIF":2.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light transmission and thermal impact of different photobiomodulation therapy devices on the Achilles tendon of human volunteers: A comparative study","authors":"Ernesto Cesar Pinto Leal-Junior ,&nbsp;Fernando Hess ,&nbsp;Luana Barbosa Dias ,&nbsp;Matheus Marinho Aguiar Lino ,&nbsp;Caroline dos Santos Monteiro Machado ,&nbsp;Paulo Henrique Gusmão Nogueira Martins ,&nbsp;Heliodora Leão Casalechi ,&nbsp;Shaiane Silva Tomazoni","doi":"10.1016/j.pdpdt.2025.105234","DOIUrl":"10.1016/j.pdpdt.2025.105234","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between light transmission and thermal effects of different photobiomodulation therapy devices on deeper tissues remains unclear.</div></div><div><h3>Aim</h3><div>To compare light transmission and thermal effects of three photobiomodulation therapy devices on the in situ Achilles tendon of healthy adults.</div></div><div><h3>Methods</h3><div>A clinical exploratory study was conducted. Eighteen male volunteers (<em>n</em> = 36 tendons) underwent irradiation with three photobiomodulation therapy devices: a high-powered single-wavelength (HPSW, 9,000 mW), a low-powered single-wavelength (LPsW, 100 mW), and a low-powered multi-wavelength (LPmW, 450 mW). Tissue thickness, transmitted power, skin temperature, and thermal discomfort were assessed.</div></div><div><h3>Results</h3><div>Achilles tendon thickness did not differ across conditions (<em>p</em> &gt; 0.05). The LPmW device exhibited the highest transmitted power (141.1 μW ± 33.5) compared with the HPSW (39.7 μW ± 27.0) and LPsW (23.9 μW ± 10.5) devices (<em>p</em> &lt; 0.0001), as well as the lowest increase in skin temperature (<em>p</em> &gt; 0.05). The HPSW device induced the greatest thermal discomfort (<em>p</em> &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>These findings suggest that the LPmW device delivers greater transmitted power while causing a smaller increase in skin temperature compared with the LPsW and HPSW devices in the resting human Achilles tendon, making it a potentially safer and more efficient option for deeper tissue treatment.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105234"},"PeriodicalIF":2.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiating primary open-angle, exfoliative, and primary angle-closure glaucoma in moderate-stage cases using blood-based inflammatory indices and structural metrics","authors":"Atılım Armağan Demirtaş ,&nbsp;Berna Yüce ,&nbsp;Bediz Özen","doi":"10.1016/j.pdpdt.2025.105233","DOIUrl":"10.1016/j.pdpdt.2025.105233","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to evaluate the discriminative utility of systemic hematological inflammatory markers—namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR)—in differentiating between primary open-angle glaucoma (POAG), exfoliative glaucoma (XFG), and primary angle-closure glaucoma (PACG) in moderate-stage cases, as well as from healthy controls. In addition, the discriminative performance of structural (cup-to-disc ratio [C/D] and retinal nerve fiber layer [RNFL] thickness) parameters was also assessed.</div></div><div><h3>Methods</h3><div>A retrospective study was conducted, including 166 participants aged 40–70 years (55 POAG, 51 XFG, 30 PACG, 30 controls). All subjects underwent comprehensive ophthalmologic evaluation, optical coherence tomography, and standard automated perimetry. Systemic inflammatory markers were calculated from complete blood counts. Differences between groups were evaluated, and ROC analyses were performed for each parameter.</div></div><div><h3>Results</h3><div>No significant differences in age, gender, or intraocular pressure were observed between groups. C/D ratio was significantly higher in all glaucoma subtypes compared to controls (<em>p</em> = 0.001), while RNFL thickness was lower in glaucoma patients but did not differ significantly between subtypes (<em>p</em> = 0.057). Inflammatory indices did not show significant intergroup differences (p &gt; 0.05), but ROC analysis demonstrated modest diagnostic value in specific comparisons. LMR had the highest AUC (0.635) in distinguishing POAG from controls. NLR showed moderate performance in differentiating POAG from XFG (AUC=0.621) and XFG from PACG (AUC=0.627).</div></div><div><h3>Conclusions</h3><div>Systemic inflammatory indices such as NLR and LMR demonstrated modest but measurable discriminative value in differentiating glaucoma subtypes with moderate-stage and controls. Structural parameters (C/D ratio and RNFL thickness) confirmed expected differences between glaucoma and control eyes but did not reliably distinguish among glaucoma subtypes.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105233"},"PeriodicalIF":2.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of 5-azacitidine and photodynamic therapy using spirulina platensis on cell death in CAL27 oral squamous cell carcinoma Cells","authors":"Alireza Ranjbar ,&nbsp;Sima Shahabi ,&nbsp;Mojgan Alaeddini ,&nbsp;Hadiseh Mohammadpour ,&nbsp;Mahshid Hodjat ,&nbsp;Sogol Saberi","doi":"10.1016/j.pdpdt.2025.105232","DOIUrl":"10.1016/j.pdpdt.2025.105232","url":null,"abstract":"<div><h3>Background</h3><div>Oral squamous cell carcinoma (OSCC) remains a major clinical challenge with high mortality and limited treatment responsiveness. Epigenetic therapy with 5-azacitidine (5-aza), a DNA methyltransferase inhibitor, and photodynamic therapy (PDT) using natural photosensitizers have independently shown promise in enhancing cancer cell death.</div></div><div><h3>Objective</h3><div>This study investigates the synergistic effect of combining 5-aza and Spirulina-based PDT on OSCC cells.</div></div><div><h3>Methods</h3><div>Human OSCC (CAL27) and normal gingival fibroblast (HGF) cells were treated with 5-aza, Spirulina extract-based PDT, or their combination. Cytotoxicity was evaluated by MTT assay; migration by wound healing; invasion by MMP2/9 gene expression; apoptosis by flow cytometry; and DNA fragmentation by comet assay.</div></div><div><h3>Results</h3><div>The combination therapy significantly reduced CAL27 cell viability while sparing normal HGF cells. Cell migration and invasion were markedly suppressed, with downregulation of MMP2 and MMP9. Apoptosis rates and DNA damage were significantly higher in the combined treatment group than in either monotherapy.</div></div><div><h3>Conclusion</h3><div>Spirulina-based PDT enhances the antitumor efficacy of 5-aza in OSCC by inducing synergistic cytotoxic, apoptotic, and anti-invasive effects. These findings support the therapeutic potential of combining epigenetic and oxidative stress-based modalities in OSCC management.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105232"},"PeriodicalIF":2.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical management of macular telangiectasia type 2-associated macular hole with internal limiting membrane deficiency and imaging assessment of müller cell function","authors":"Nianjia Wang ,&nbsp;Jiayi Wu ,&nbsp;Xintong Xiang ,&nbsp;Ke Wu ,&nbsp;Yujia Gao ,&nbsp;Liang Yao ,&nbsp;Yuping Zheng","doi":"10.1016/j.pdpdt.2025.105236","DOIUrl":"10.1016/j.pdpdt.2025.105236","url":null,"abstract":"<div><div>This study presents a rare case of macular telangiectasia type 2 (Mac Tel 2) with a secondary full-thickness macular hole, in which an unexpected internal limiting membrane (ILM) deficiency was discovered intraoperatively. Swept-source OCT angiography (SS-OCTA) volumetric data were utilized to construct 3D models for the assessment of Müller cell function. Although ILM flap surgery achieved initial anatomical closure and visual improvement, the hole reopened after six years, with corresponding vision decline. Intraoperative ICG staining revealed patchy ILM absence, indicating severe Müller cell dysfunction. 3D vascular and structural analysis demonstrated topographic collapse correlating with loss of cytoskeletal support from Müller cells, explaining the temporary surgical success and subsequent recurrence. The findings suggest that long-term closure of Mac Tel 2-associated macular holes depends on underlying disease progression rather than surgical technique alone. For eyes with advanced Müller cell degeneration, alternative closure materials should be considered. This case highlights the critical role of vascular and structural 3D imaging in evaluating cellular function and predicting surgical outcomes.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105236"},"PeriodicalIF":2.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ex vivo assessment of blue laser-activated berberine-loaded nanoniosomes in enhancing photodynamic therapy against Streptococcus mutans biofilm on tooth enamel","authors":"Maryam Pourhajibagher ,&nbsp;Ehsan Kazemi Moghaddam ,&nbsp;Mohammadreza Moeininejad ,&nbsp;Bahman Rahimi Esboei ,&nbsp;Abbas Bahador","doi":"10.1016/j.pdpdt.2025.105229","DOIUrl":"10.1016/j.pdpdt.2025.105229","url":null,"abstract":"<div><div>Background: Dental caries is a biofilm-mediated disease primarily caused by Streptococcus mutans, which produces extracellular polysaccharides via glucosyltransferases such as GtfB, promoting biofilm formation and cariogenicity. Photodynamic therapy (PDT) has gained attention as a promising alternative to conventional antimicrobials. This study investigates the efficacy of blue laser-activated berberine-loaded nanoniosomes (nNios@Ber) in enhancing PDT against S. mutans biofilms formed on tooth enamel.</div><div>Materials and Methods: An <em>ex vivo</em> model using human tooth enamel slabs was employed to cultivate S. mutans biofilms. Berberine was encapsulated in nanoniosomes (nNios@Ber) to improve stability and delivery. Following determination of minimum inhibitory concentration (MIC) of nNios@Ber, biofilms were treated with various concentrations of nNios@Ber combined with blue laser irradiation (405 ± 10 nm) to activate PDT. Additionally, quantitative real-time PCR was used to quantify <em>gtfB</em> gene expression.</div><div>Results: The MIC of nNios@Ber against <em>S. mutans</em> was found to be 15.6 μg/mL. All PDT-treated groups showed significant reductions in biofilm viability and a dose-dependent downregulation of <em>gtfB</em> expression. Specifically, <em>gtfB</em> expression decreased by 4.8-, 5.7-, and 7.4-fold in the 2 × MIC, 4 × MIC, and 8 × MIC nNios@Ber plus blue laser groups, respectively (<em>P</em> &lt; 0.05). Neither nNios@Ber nor laser alone produced statistically significant effects (<em>P</em> &gt; 0.05). These findings confirm that nNios@Ber’s anti-biofilm efficacy is enhanced when photoactivated by blue laser.</div><div>Conclusion: Blue laser-activated nNios@Ber significantly inhibit S. mutans biofilm formation and virulence gene expression, offering an effective and targeted approach for caries management. This photoactivated nNios@Ber enhances the photodynamic activity, providing a promising adjunct or alternative to conventional antimicrobial agents such as CHX in oral healthcare.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105229"},"PeriodicalIF":2.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory angular cheilitis treated with photodynamic therapy (PDT): an observational pilot study","authors":"Cinzia Casu ,&nbsp;Valentino Natoli ,&nbsp;Angelo Michele Inchingolo ,&nbsp;Germano Orrù","doi":"10.1016/j.pdpdt.2025.105228","DOIUrl":"10.1016/j.pdpdt.2025.105228","url":null,"abstract":"<div><h3>Background/Objectives</h3><div>The aim of this observational pilot study is to identify whether photodynamic therapy, performed with two different protocols, can be effective in the clinical resolution of recurrent or refractory angular cheilitis, previously treated with gold standard topical pharmacological therapy without results.</div></div><div><h3>Methods</h3><div>The selected patients were treated with: 1) 1 % phenothiazine chloride protocol; 2) curcumin-based photosensitizer protocol. Patients were observed at 1 week, 1 month and 3 months follow up.</div></div><div><h3>Results</h3><div>Data were collected from 10 treated patients who met our inclusion criteria, 7 women and 3 men, 1 of them smoker, with a mean age of 51,4 years, the youngest being 38 years and the oldest 81 years. Healing occurred in 9 out of 10 cases. One case showed incomplete healing, one case showed recurrence after one month.</div></div><div><h3>Conclusions</h3><div>Photodynamic therapy for the treatment of refractory or recurrent angular cheilitis could be considered a valid therapeutic alternative, with limited side events.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105228"},"PeriodicalIF":2.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epithelial remodeling associated with corneal power and corneal higher-order aberrations after ray-tracing guided FS-LASIK for myopia","authors":"Jiayu Li ,&nbsp;Yuyan Huang ,&nbsp;Yanzheng Song ,&nbsp;Yushan Xu ,&nbsp;Yixin Zhang ,&nbsp;Jie Wen ,&nbsp;Zecheng Wang ,&nbsp;Fengju Zhang","doi":"10.1016/j.pdpdt.2025.105230","DOIUrl":"10.1016/j.pdpdt.2025.105230","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate epithelial remodeling, corneal power distribution and corneal higher-order aberrations (HOAs) after ray tracing-guided femtosecond laser-assisted in situ keratomileusis (RG FS-LASIK) for myopia.</div></div><div><h3>Methods</h3><div>66 eyes from 33 patients were included in this 6-month observational case series. Epithelial thickness (ET), total corneal refractive power (TCRP), corneal HOAs, corneal volume (CV), and Quality of Vision questionnaire were assessed. Concentrical TCRP gradient was calculated (△Km_n = Km_n+1 - Km_n).</div></div><div><h3>Results</h3><div>ET in 0–2 mm only increased by 2.97 ± 4.57 μm with the myopic correction of - 6.24±1.78 D. No difference between steep and flat meridians was identified (<em>P</em> &gt; 0.050). Km maintained a rate of decline in 1–3 mm and gently raised across 4–6 mm. ET thickening in 2–5 mm showed positive associations with TCRP gradient (<em>r</em> of △Km₃, △Km₄, and △Km₅ were 0.304, 0.399, and 0.357; all <em>P</em> &lt; 0.050). And greater mean and inferior remodeling in this annulus were related to increased spherical aberration and vertical coma at 6 mm (<em>r</em> = 0.414 and −0.505; both <em>P</em> &lt; 0.001), correspondingly severer focusing difficulties and milder double vision occurred (<em>coef</em> = 8.665 and 3.612, both <em>P</em> &lt; 0.050). CV₃ consumption correlated negatively with △Km₁ and △Km₂ (<em>r</em> = −0.522 and −0.475, both <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Epithelial thickening was minimal in central zone and comparable between astigmatism axes after RG FS-LASIK. Though the visual symptoms were subtle, pronounced paracentral remodeling associated with novel ablation profile and postoperative development of corneal HOAs still requires continuous monitoring.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105230"},"PeriodicalIF":2.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}