Photodiagnosis and Photodynamic Therapy最新文献

{"title":"The effect of antimicrobial photodynamic therapy using different concentrations of phycocyanin against Streptococcus mutans","authors":"Zahra Abbasianfar ,&nbsp;Bahman Seraj ,&nbsp;Shima Afrasiabi ,&nbsp;Mohammad Javad Kharazi Fard ,&nbsp;Sara Ghadimi ,&nbsp;Nasim Chiniforush","doi":"10.1016/j.pdpdt.2024.104384","DOIUrl":"10.1016/j.pdpdt.2024.104384","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study is to investigate the effect of antimicrobial photodynamic therapy (aPDT) using three different concentrations of phycocyanin and two different laser powers on <em>Streptococcus mutans</em>.</div></div><div><h3>Materials and methods</h3><div>In this study, <em>Streptococcus mutans</em> was investigated using three different concentrations of phycocyanin (2.5, 5, and 10 mg/mL), in the presence and absence of 635 nm diode laser at two power levels (400 and 500 mW). The treatments were as follows: the control group received no treatment. The next 3 groups received only the phycocyanin at 2.5, 5, and 10 mg/mL. The remaining groups received both phycocyanin and laser treatment. Finally, bacteria were counted using the colony forming units (CFUs)/mL method. Data analysis was performed using IBM SPSS 26 software and ANOVA statistical test.</div></div><div><h3>Results</h3><div>All groups except for the phycocyanin group at a concentration of 10 mg/mL showed a statistically significant difference compared to the control group (<em>p</em>-Value &lt; 0.05). Additionally, the least effect was observed in the control and the phycocyanin at a concentration of 10 mg/mL groups, while the greatest effect was found in the group receiving phycocyanin at 2.5 mg/mL concentration and laser with a power of 500 mW (2.5 + DL500).</div></div><div><h3>Conclusion</h3><div>aPDT can be used as a complementary and non-invasive method to reduce bacterial load. The effectiveness of aPDT decreased with increasing phycocyanin concentration. Moreover, higher laser irradiation power resulted in reduced <em>Streptococcus mutans</em> bacterial load. Thus, the most pronounced effects were observed in the group receiving phycocyanin at 2.5 mg/mL concentration and 635 nm diode laser with a power of 500 mW (2.5 + DL500).</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104384"},"PeriodicalIF":3.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ability of changes in oct angiography values to predict visual field and retinal nerve layer tomography progression in patients with glaucoma progression: A prospective study","authors":"Suleyman Demir,&nbsp;Mehmet Talay Koylu,&nbsp;Alper Can Yılmaz","doi":"10.1016/j.pdpdt.2024.104382","DOIUrl":"10.1016/j.pdpdt.2024.104382","url":null,"abstract":"<div><h3>Introduction</h3><div>To investigate whether changes in optical coherence tomography angiography (OCTA) values can predict progression in the visual field (VF) and retinal nerve fiber layer (RNFL) in patients with glaucoma progression.</div></div><div><h3>Methods</h3><div>All patients in the glaucoma outpatient clinic of SBU Gulhane Medicine Faculty between 2021 and 2023 underwent RNFL, 24:2 VF, and simultaneous peripapillary OCTA. 130 eyes that progressed were included in the study. Thinning of more than 5 μ in any quadrant in the RNFL or a decrease of more than 1 dB in the MD value in the visual field within 6 months was accepted as a progression criterion. The ability of changes in OCTA thickness values and OCTA radial peripapillary capillary plexus (RPCP) analysis to predict progression in RNFL and VF was prospectively investigated.</div></div><div><h3>Results</h3><div>The mean age of the patients was 66.9 ± 11.8 years. There was progression in VF in 70 eyes and RNFL in 89 eyes between baseline and 6-month controls. The change in OCTA thickness values had insufficient ability to predict the progression of RNFL in the superior, inferior, nasal, temporal and total quadrants (<em>p</em> = 0.55, 0.40, 0.84, 0.91, 0.39, respectively). The changes in OCTA thickness values failed to predict VF MD progression in the superior, inferior,nasal,temporal,and total quadrants (<em>p</em> = 0.40, 0.11, 0.24, 0.44, 0.10, respectively). The changes in OCTA RPCP values ​​did not show superiority in the ability to predict RNFL progression in superior, inferior, nasal, temporal, and total quadrants (<em>p</em> = 0.21, 0.53, 0.39, 0.39, 0.29, respectively). The changes in OCTA RPCP values ​​did not show superiority in the ability to predict VF progression in superior, inferior, nasal, temporal, and total quadrants (<em>p</em> = 0.96, 0.29, 0.77, 0.42, 0.21, respectively).</div></div><div><h3>Conclusion</h3><div>Although OCTA is a non-invasive imaging test whose use and popularity have been increasing in recent years, our study could not show superiority compared to RNFL and VF tests in demonstrating glaucoma progression.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104382"},"PeriodicalIF":3.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior corneal elevation after small incision lenticule extraction (SMILE) in eyes of different myopia severity","authors":"Li Jiang ,&nbsp;Changting Tang ,&nbsp;Bao Shu ,&nbsp;Ying Liu ,&nbsp;Qingyan Zeng ,&nbsp;Xiaohua Lei ,&nbsp;Zhengwei Shen ,&nbsp;Yijun Hu","doi":"10.1016/j.pdpdt.2024.104392","DOIUrl":"10.1016/j.pdpdt.2024.104392","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the changes in posterior corneal elevation after small incision lenticule extraction (SMILE) surgery in eyes of different myopia severity.</div></div><div><h3>Methods</h3><div>A total of 141 eyes of 86 patients were recruited and followed at 1 month, 3 months, 6 months, and 12 months after SMILE surgery. The eyes were divided into four groups according to the spherical equivalent (SE): low myopia (LM, −3.00 D≤SE&lt;−0.50 D, 35 eyes), moderate myopia (MM, −6.00 D≤SE&lt;−3.00 D, 54 eyes) and high myopia (HM, −10.00 D≤SE&lt;−6.00 D, 52 eyes). Posterior corneal elevation was measured by Pentacam HR. Posterior corneal apex elevation (PCAE), posterior maximum elevation (PME), and posterior elevation at the thinnest point of the cornea (TPC) in the central 4-mm area were recorded and compared among different examination time points in the same group or among different groups at the same time point.</div></div><div><h3>Results</h3><div>Uncorrected distance visual acuity (UDVA) at 12 months was 20/20 or better in 100.00 % of eyes in LM group, 100.00 % in MM group and 96.15 % in HM group (<em>P</em> &gt; 0.05). There were significant reductions of post-operative PCAE compared to baseline in the LM group (<em>P</em> = 0.038) and HM group (<em>P</em>&lt;0.001), and the reduction was marginally significant in the MM group (<em>P</em> = 0.076). No statistically significant changes in PME were observed after SMILE surgery in the three groups (all <em>P</em> &gt; 0.05). TPC was significantly decreased after the surgery in the MM group (<em>P</em> = 0.022) and the HM group (<em>P</em>&lt;0.001), and was marginally significantly decreased in the LM group (<em>P</em> = 0.063). There was no significant difference in PCAE and PME among the three groups at baseline or any postoperative timepoint (all <em>P</em> &gt; 0.05). TPC was significantly different among the three groups at 3 months, 6 months and 12 months (all <em>P</em> &lt; 0.05), but not at baseline (<em>P</em> = 0.066) or 1 month (<em>P</em> = 0.080).</div></div><div><h3>Conclusion</h3><div>In the first year after SMILE surgery, PCAE was decreased in both LM and HM eyes, and TPC were decreased in MM and HM eyes, but PME was stable after the surgery.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104392"},"PeriodicalIF":3.1,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of central corneal thickness in ocular hypertension and healthy individuals","authors":"Yu Zhang","doi":"10.1016/j.pdpdt.2024.104393","DOIUrl":"10.1016/j.pdpdt.2024.104393","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to compare the central corneal thickness (CCT) between patients with ocular hypertension (OHT) and healthy individuals, and to investigate the relationship between CCT and intraocular pressure (IOP), diopter, and corneal endothelium cell count (CECC).</div></div><div><h3>Methods</h3><div>The CCT of 30 healthy subjects and 38 patients with OHT was measured using a non-contact specular microscope. IOP, diopter, and CECC were also assessed for all participants. Comparative analysis of CCT between the two groups was performed, along with correlation analysis between CCT and each parameter.</div></div><div><h3>Results</h3><div>The average CCT for all participants was 527.57 ± 35.84 µm. The average CCT was 516.07 ± 34.76 µm for healthy subjects and 536.66 ± 34.46 µm for patients with ocular hypertension, showing a significant difference between the two groups (<em>P</em> ≤ 0.05). CCT was not correlated with age (Pearson <em>r</em> = -0.098, <em>P</em> = 0.426), diopter (spherical equivalent refraction) (Pearson <em>r</em> = -0.158, <em>P</em> = 0.197), or corneal endothelium cell count (Pearson <em>r</em> = 0.065, <em>P</em> = 0.598). However, a positive correlation was found between ocular hypertension and central corneal thickness (Pearson <em>r</em> = 0.278, <em>P</em> = 0.022).</div></div><div><h3>Conclusion</h3><div>Patients with ocular hypertension of members of the Chinese Han population exhibited greater CCT compared to healthy subjects in this study. CCT showed no association with age, diopter, or corneal endothelium cell count; however, a positive correlation was observed between intraocular pressure and CCT. With CCT as the abscissa and IOP as the ordinate, the linear regression equation is <em>Y</em> = 0.05+0.021X (<em>F</em> = 5.508, <em>P</em> = 0.022). The use of non-contact tonometers for measuring CCT may impact the accuracy of diagnosing and treating glaucoma and ocular hypertension.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104393"},"PeriodicalIF":3.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of polymer-based porphyrin-incorporated reference materials for calibration of quantitative light-induced fluorescence device","authors":"Sang-Eun Park ,&nbsp;Hong-Cheol Yoon ,&nbsp;Elbert de Josselin de Jong ,&nbsp;Kwang-Mahn Kim ,&nbsp;Jae-Sung Kwon","doi":"10.1016/j.pdpdt.2024.104391","DOIUrl":"10.1016/j.pdpdt.2024.104391","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed at developing and validating polymer-based reference materials with varying amounts of porphyrin to accurately assess and calibrate quantitative light-induced fluorescence (QLF) device.</div></div><div><h3>Methods</h3><div>Reference materials with porphyrin concentrations ranging from 0 to 0.08 wt.% were prepared. The surface properties of the materials were analyzed via gloss and roughness measurements. Color analysis of the specimens was performed on black and white backgrounds with or without filters using a spectrophotometer. This approach revealed the correlations between fluorescence and color. The fluorescence emitted by the specimens was analyzed by measuring ΔR and ΔRmax values using a QLF-D Biluminator™.</div></div><div><h3>Results</h3><div>The surface gloss and roughness of the reference materials were not affected by the porphyrin content (<em>p</em> &gt; 0.005). Spectrophotometric measurements revealed significant color differences among most specimen groups depending on the background color and the presence of a filter. QLF-D imaging revealed significant differences in fluorescence (ΔR and ΔRmax) among all specimen groups regardless of the background. The fluorescence values observed on the black backgrounds were higher than those observed on the white backgrounds (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>The developed polymer-based porphyrin-incorporated materials serve as reliable reference standards for accurate assessment and calibration of QLF devices. This study demonstrates the importance of background conditions in fluorescence detection and highlights the potential of these materials as standards for QLF device calibration.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104391"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metrics of retinal vasculature detected on OCTA in carotid artery stenosis: A systematic review and meta-analysis","authors":"Kaibao Ji ,&nbsp;Yang Yang ,&nbsp;Yiqiao Xing,&nbsp;Wei Wan","doi":"10.1016/j.pdpdt.2024.104390","DOIUrl":"10.1016/j.pdpdt.2024.104390","url":null,"abstract":"<div><h3>Background</h3><div>Carotid artery stenosis (CAS) is a major cause of cerebral microcirculation dysfunction, contributing to 15–20% of ischemic strokes. Retinal vessel changes is associated with several systemic diseases, including CAS. This systematic review investigates retinal microvascular alterations measured using optical coherence tomography angiography (OCTA) in patients with CAS.</div></div><div><h3>Methods</h3><div>We comprehensively searched the electronic databases, namely PubMed, Cochrane Library, Embase, and Web of Science. Macular and optic nerve head vascular density (VD) in patients with CAS were compared to controls. Pooled data for each outcome were calculated as standardized mean difference (SMD) and 95% confidence interval. OCTA parameters were analyzed using Review Manager Version 5.4.1 software.</div></div><div><h3>Results</h3><div>Seven articles were included in this meta-analysis. Whole macular enface superficial and deep VD were significantly lower in patients with CAS than in controls (SMD = -0.97, P = 0.002; SMD = -1.05, P = 0.006, respectively). Additionally, the parafoveal superficial VD was significantly lower in the CAS group than in the healthy group (SMD = -0.71, P= 0.001). Radial peripapillary capillary (RPC) whole-image VD (SMD = -0.90, P&lt; 0.0001), RPC inside disc VD (SMD = -0.49, P = 0.02), and RPC peripapillary VD (SMD = -0.64, P = 0.0003) were also significantly lower in patients with CAS compared to healthy individuals.</div></div><div><h3>Conclusion</h3><div>These findings suggest that patients with CAS are prone to decreased VD in the macular and optic nerve head areas. Hence, OCTA shows potential as a promising tool for the early detection of cerebral microcirculation disorders due to CAS.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104390"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation therapy at 650 nm enhances osteogenic differentiation of osteoporotic bone marrow mesenchymal stem cells through modulating autophagy","authors":"Haotian Li ,&nbsp;Wenwen Yang ,&nbsp;Biao Zhu ,&nbsp;Miao Li ,&nbsp;Xinran Zhang","doi":"10.1016/j.pdpdt.2024.104389","DOIUrl":"10.1016/j.pdpdt.2024.104389","url":null,"abstract":"<div><h3>Background</h3><div>Photobiomodulatiom therapy (PBMT) has biostimulatory effects on bone marrow mesenchymal stem cells (BMSCs), which takes a pivotal role in maintaining bone mass and avoiding osteoporosis (OP). Autophagy is an important regulator for cell survival and homeostasis. Previous researchers found that BMSCs derived from osteoporotic rats (OP-BMSCs) were with the feature of reduced osteogenic differentiation and autophagy dysfunction. However, the potential regulation of PBMT in osteogenic differentiation of OP-BMSCs and its underling relationship with autophagy remain unclear.</div></div><div><h3>Methods</h3><div>650 nm red light-emitting diode (LED) was selected to initiate PBMT effects. The isolation and culture of OP-BMSCs were implemented after the establishment of the OP rat model. Firstly, the optimal dose of LED was screened on OP-BMSCs by CCK-8. Meanwhile, the osteogenic and mineralization activities were studied through the detection of Alkaline phosphatase (ALP) and alizarin red S (ARS). Then, the levels of osteogenesis and autophagy were investigated via western blot and immunofluorescence staining. Finally, the autophagy inhibitor 3-MA was applied to illustrate the underlying mechanism of the osteogenic effect of PBMT on OP-BMSCs.</div></div><div><h3>Results</h3><div>Firstly, the optimal dose of 6 J/cm² LED was selected in the subsequent experiments according to CCK-8. Then, the ALP activity and the mineralization ability of OP-BMSCs were obviously increased by PBMT. Meanwhile, Runx-2, OCN and OPN were significantly upregulated in LED group. Furthermore, the expressions of autophagic proteins increased significantly in LED group by immunofluorescence staining and western blot assay. At last, the promoted effects of PBMT on osteogenic differentiation in OP-BMSCs were distinctly reversed via inhibiting autophagy.</div></div><div><h3>Conclusion</h3><div>Our research illustrated that 650 nm LED could improve osteogenic differentiation of OP-BMSCs, suggesting a potential correlation between PBMT-mediated activation of autophagy and promotion of osteogenic differentiation.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104389"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and pre-clinical advances in the PDT/PTT strategy for diagnosis and treatment of cancer","authors":"Coralía Fabiola Cuadrado ,&nbsp;Karina J. Lagos ,&nbsp;Mirian Denise Stringasci ,&nbsp;Vanderlei Salvador Bagnato ,&nbsp;María Paulina Romero","doi":"10.1016/j.pdpdt.2024.104387","DOIUrl":"10.1016/j.pdpdt.2024.104387","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) and photothermal therapy (PTT) have demonstrated great potential to diagnose and combat localized cancers. As a matter of fact, these techniques are less invasive and have fewer side effects than traditional cancer treatments like surgery, chemotherapy or radiotherapy. This review summarizes the clinical progress in the theranostics (diagnosis and treatment) of various types of regional cancers using these two light stimuli techniques, PDT and PTT. Therefore, clinical advances in cancer diagnosis based on PDT are detailed, including fluorescence-guided PDT for intraoperative cancer detection, optical coherence tomography (OCT)-guided PDT for early cancer detection, and imaging by magnetic resonance imaging (MRI) or computed tomography (CT) assisted through PDT/PTT. Moreover, clinical studies of breast, prostate, skin, gynecologic, head, neck and other varieties of cancer have been addressed to compare the main conditions of these treatments. This work also discussed the principal advantages and drawbacks of PDT and PTT in tumor targeting and cancer therapy. Finally, the usage of nanoparticles as photosensitizers (PSs) and photothermal agents (PAs) have been analyzed. In this manner, the authors have compiled relevant updated studies so that researchers interested in these areas can access it speedily.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104387"},"PeriodicalIF":3.1,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current research status of Raman spectroscopy in glioma detection","authors":"Jie Liu ,&nbsp;Pan Wang ,&nbsp;Hua Zhang ,&nbsp;Yuansen Guo ,&nbsp;Mingjie Tang ,&nbsp;Junwei Wang ,&nbsp;Nan Wu","doi":"10.1016/j.pdpdt.2024.104388","DOIUrl":"10.1016/j.pdpdt.2024.104388","url":null,"abstract":"<div><div>Glioma is the most common primary tumor of the nervous system. Conventional diagnostic methods for glioma often involve time-consuming or reliance on externally introduced materials. Consequently, there is an urgent need for rapid and reliable diagnostic techniques. Raman spectroscopy has emerged as a promising tool, offering rapid, accurate, and label-free analysis with high sensitivity and specificity in biomedical applications. In this review, the fundamental principles of Raman spectroscopy have been introduced, and then the progress of applying Raman spectroscopy in biomedical studies has been summarized, including the identification and typing of glioma. The challenges encountered in the clinical application of Raman spectroscopy for glioma have been discussed, and the prospects have also been envisioned.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104388"},"PeriodicalIF":3.1,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and assessment of diabetic retinopathy in a densely populated suburban area of Tianjin, China – The Beichen Eye Study","authors":"Luxi Li,&nbsp;Liying Hu,&nbsp;Fei Gao,&nbsp;Yu Shi,&nbsp;Chen Chen,&nbsp;Xiuqing Zhu,&nbsp;Juping Liu,&nbsp;Xiaorong Li","doi":"10.1016/j.pdpdt.2024.104385","DOIUrl":"10.1016/j.pdpdt.2024.104385","url":null,"abstract":"<div><h3>Purpose</h3><div>The aim of this study is to explore the prevalence, associated risk factors, and the influence of urbanization on the epidemiology of diabetic retinopathy (DR) and diabetic macular edema (DME).</div></div><div><h3>Methods</h3><div>This study utilized a cross-sectional design to survey residents aged 50 and older in the Beichen community, Tianjin. Participants underwent thorough examinations, including questionnaire surveys, laboratory blood tests, eye assessments, fundus photography, and optical coherence tomography (OCT) scans. DR was diagnosed using the retinopathy severity scale from fundus photographs based on the Early Treatment Diabetic Retinopathy Study (ETDRS) classification system. DME was identified through medical history records and OCT evaluations. In this study, we analyzed and assessed the prevalence and risk factors associated with DR and DME.</div></div><div><h3>Results</h3><div>The study included 5,648 participants, and 1,182 of these were diagnosed with diabetes. Among the diabetic individuals, the prevalence of DR was 28.8%. Among the eyes of those diagnosed with DR, 37.12% had mild non-proliferative DR (NPDR), 54.81% had moderate NPDR, 6.35% (33 eyes) showed severe NPDR, and 1.73% had proliferative DR (PDR). The prevalence of DME among diabetic patients was 14.13%. Age was negatively correlated with DR (OR, 0.924), while blood glucose levels (OR, 1.123) and the duration of diabetes (OR, 1.090) were positively correlated. Additionally, blood glucose levels (OR, 1.121) and the duration of diabetes (OR, 1.070) were positively associated with DME.</div></div><div><h3>Conclusion</h3><div>In this study, the prevalence of DR and DME was high in the Beichen District of Tianjin than in other parts of China. Maintaining effective glycemic control is the most important modifiable factor in reducing the risk of DR and DME progression and minimizing the risk of vision loss.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104385"},"PeriodicalIF":3.1,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}