Refractory angular cheilitis treated with photodynamic therapy (PDT): an observational pilot study

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-09-23 DOI:10.1016/j.pdpdt.2025.105228

Cinzia Casu , Valentino Natoli , Angelo Michele Inchingolo , Germano Orrù

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引用次数: 0

Abstract

Background/Objectives

The aim of this observational pilot study is to identify whether photodynamic therapy, performed with two different protocols, can be effective in the clinical resolution of recurrent or refractory angular cheilitis, previously treated with gold standard topical pharmacological therapy without results.

Methods

The selected patients were treated with: 1) 1 % phenothiazine chloride protocol; 2) curcumin-based photosensitizer protocol. Patients were observed at 1 week, 1 month and 3 months follow up.

Results

Data were collected from 10 treated patients who met our inclusion criteria, 7 women and 3 men, 1 of them smoker, with a mean age of 51,4 years, the youngest being 38 years and the oldest 81 years. Healing occurred in 9 out of 10 cases. One case showed incomplete healing, one case showed recurrence after one month.

Conclusions

Photodynamic therapy for the treatment of refractory or recurrent angular cheilitis could be considered a valid therapeutic alternative, with limited side events.

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用光动力疗法（PDT）治疗难治性角性舌炎：一项观察性初步研究。

背景/目的：本观察性初步研究的目的是确定两种不同方案的光动力疗法是否能有效地临床解决复发性或难治性角性口炎，以前用金标准局部药物治疗没有结果。方法：选择的患者采用：1)1%氯吩噻嗪方案；2)基于姜黄素的光敏剂方案。随访1周、1个月、3个月。结果：我们收集了符合纳入标准的10例治疗患者的数据，其中7名女性，3名男性，1名吸烟者，平均年龄54.1岁，最小38岁，最大81岁。10例中有9例愈合。1例愈合不完全，1例1个月后复发。结论：光动力疗法治疗难治性或复发性角唇炎可被认为是一种有效的治疗选择，没有副作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.