Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Erratum to “Agent-Specific Differences in Sustained Intraoperative Hypotension during oral 5-Aminolevulinic Acid-Guided Transurethral Resection of Bladder Tumor: A Retrospective Observational Study” [Photodiagnosis and Photodynamic Therapy 57C (2026) 105319]","authors":"Yoshifumi Katsumata , Shinkuro Yamamoto , Hideki Iwata , Hajime Kuroiwa , Hideo Fukuhara , Satoshi Fukata , Keiji Inoue , Takashi Kawano","doi":"10.1016/j.pdpdt.2026.105358","DOIUrl":"10.1016/j.pdpdt.2026.105358","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105358"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146128036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Retinal microvascular changes in patients recovered from COVID-19 compared to healthy controls: a meta-analysis” [Photodiagnosis and Photodynamic Therapy 42C (2023)103556]","authors":"Dimitrios Kazantzis, Genovefa Machairoudia, George Theodossiadis, Panagiotis Theodossiadis, Irini Chatziralli","doi":"10.1016/j.pdpdt.2026.105377","DOIUrl":"10.1016/j.pdpdt.2026.105377","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105377"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of the cycloplegic vision screener V100 and desktop autorefractometer compared to retinoscopy in children: A comparative study with literature findings","authors":"Mahmut Dogan ,&nbsp;Zekeriya Cetinkaya","doi":"10.1016/j.pdpdt.2026.105338","DOIUrl":"10.1016/j.pdpdt.2026.105338","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the cycloplegic accuracy of the Vision Screener V100 (VS) and a desktop autorefractometer (TAR) in comparison with cycloplegic retinoscopy (CR) in children, and to compare the findings with current literature.</div></div><div><h3>Methods</h3><div>This prospective observational study included 50 pediatric patients (100 eyes) with a mean age of 9.8 ± 1.7 years. Cycloplegic measurements were obtained using the VS, TAR, and CR. Agreement between methods was analyzed using intraclass correlation coefficients (ICC) and Bland–Altman plots. Differences in spherical and cylindrical values were specifically assessed.</div></div><div><h3>Results</h3><div>TAR showed excellent agreement with CR, with ICC values above 0.95 for both spherical and cylindrical measurements. In contrast, the VS demonstrated moderate correlation for spherical values (ICC ≈ 0.82) and lower correlation for cylindrical values (ICC ≈ 0.60). Bland–Altman plots revealed that TAR had narrower limits of agreement with CR, particularly for astigmatism, whereas VS showed wider variability. These findings are consistent with previous reports indicating that non-cycloplegic photoscreening devices such as the VS tend to underestimate hyperopia and show reduced reliability in astigmatism assessment.</div></div><div><h3>Conclusion</h3><div>TAR demonstrates excellent concordance with CR under cycloplegia, whereas the VS shows notably lower accuracy, especially in detecting astigmatism. Our results highlight the importance of cycloplegic evaluation for accurately assessing refractive errors in children.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105338"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hexylaminolevulinic acid in precision medicine: A review of advances in drug delivery and combination therapeutics","authors":"Lijiang Gu ,&nbsp;Pan Zhang ,&nbsp;Yibo Mei ,&nbsp;Zhongyu Wang ,&nbsp;Dalin He","doi":"10.1016/j.pdpdt.2026.105371","DOIUrl":"10.1016/j.pdpdt.2026.105371","url":null,"abstract":"<div><div>Hexylaminoacetylpropionic acid (HAL), a third-generation photosensitizer prodrug, exhibits targeted accumulation within tumor tissues and microbial biofilms. This review outlines advances in HAL-based drug delivery systems and their expanding use in various diseases, including oncology, antimicrobial therapy, and dermatologic diseases. Clinically, HAL has proven instrumental in enhancing diagnostic accuracy for bladder cancer by facilitating more complete surgical resections, while also demonstrating therapeutic efficacy against actinic keratosis and cervical intraepithelial neoplasia. These clinical advantages are complemented by novel nanocarrier systems that optimize drug delivery that improve patient tolerability. Recent findings point to an underappreciated the interplay between HAL-induced metabolic changes in tumours and anti-tumour immune responses, in which HAL-induced metabolic changes in tumours and anti-tumour immune responses, in which HAL-induced induces cell apoptosis through mitochondrial membrane permeabilization and the nuclear translocation of AIF, and enhances the efficacy of immune checkpoint blockade of key regulatory proteins reshape the tumour microenvironment and enhance immunogenicity. Thus, HAL is a candidate for combination with immune checkpoint inhibitors. However, challenges such as shallow light penetration (&lt;2 mm) and the need for long-term safety validation limit its broader clinical utility. We propose three convergent strategies to address these limitations: (i) reactive oxygen species-responsive nanocarriers for targeted delivery in hypoxic environments, (ii) biomarker-guided combinatorial regimens, and (iii) data-driven treatment personalisation using patient-specific biomarkers. Together, these advances establish a translational framework for HAL as a platform in next-generation metabolism-targeted photomedicine.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105371"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Milk-derived exosomes (MDE) for photosensitizer delivery in photodynamic therapy: A review","authors":"Kave Moloudi ,&nbsp;Nkune Williams Nkune ,&nbsp;Heidi Abrahamse ,&nbsp;Blassan P. George","doi":"10.1016/j.pdpdt.2026.105370","DOIUrl":"10.1016/j.pdpdt.2026.105370","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) is a novel light-based modality that relies on photoactivatable photosensitizers (PSs) to generate cytotoxic reactive oxygen species (ROS), but its clinical prospects are impeded by issues related to poor tumour specificity, penetration and off-target phototoxicity. Milk-derived exosomes (MDE), naturally occurring extracellular vesicles (30–150 nm in diameter) with excellent biocompatibility and low immunogenicity, have recently emerged as promising vehicles in drug delivery. MDE enhance intercellular communication by transporting proteins, lipids, and nucleic acids between cells. They have gained significant attention in recent years for their potential use in drug delivery, particularly for hydrophobic PSs, gene and protein delivery. MDE are of particular interest due to their abundance, ease of isolation, and biocompatibility. Herein we reviewed recent developments in MDE-mediated PDT, with a focus on three key areas: isolation and loading techniques, stimuli-responsive release and targeting such as pH-sensitive linkers or surface-anchored ligands (<em>e.g.</em>, folic acid), therapeutic applications and <em>in vivo</em> efficacy. Several lines of evidence showed that MDE loaded with PSs significantly enhance tumour uptake and cause severe regression <em>in vivo</em> tumour models of glioblastoma and oral cancer, following systemic or oral administration. Overall findings from this review suggest that clinical translation depends on addressing key challenges related to scalable purification, reproducible drug loading and thorough safety profile screening. Therefore, it is essential for researchers to actively standardize manufacturing processes, conduct thorough <em>in vivo</em> validation, and investigate combination therapies with modalities for enhanced therapeutic efficacy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105370"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic therapy for glans penis verrucous xanthoma: A novel, scar-free approach","authors":"XH Lu ,&nbsp;GL Ke ,&nbsp;WY Zhang ,&nbsp;T Hani ,&nbsp;VC Cleopatra ,&nbsp;J Wang ,&nbsp;Tao Yuan ,&nbsp;XL Chang ,&nbsp;CF He","doi":"10.1016/j.pdpdt.2026.105367","DOIUrl":"10.1016/j.pdpdt.2026.105367","url":null,"abstract":"<div><div>Verrucous xanthoma is an uncommon skin condition, most frequently occur in the oral cavity and other sites [<span><span>1</span></span>], and its occurrence on the glans penis is especially rare. Conventional treatment methods such as surgical excision or laser therapy often carry a risk of scarring, which may reduce glans sensitivity and negatively impact sexual function. This case report describes a successful outcome using 5-ALA PDT as a non-invasive treatment.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105367"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world outcomes of photoimmunotherapy for oral sites in head and neck cancer: A multicentre subgroup analysis","authors":"On Hasegawa ,&nbsp;Isaku Okamoto ,&nbsp;Yukiomi Kushihashi ,&nbsp;Tatsuo Masubuchi ,&nbsp;Kunihiko Tokashiki ,&nbsp;Kiyoaki Tsukahara","doi":"10.1016/j.pdpdt.2026.105360","DOIUrl":"10.1016/j.pdpdt.2026.105360","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate clinical outcomes and supportive-care needs in photoimmunotherapy (PIT) restricted to oral sites in a multicentre real-world cohort.</div></div><div><h3>Methods</h3><div>We retrospectively analysed 40 consecutive patients with unresectable, locally recurrent head and neck cancer undergoing PIT between 1 January 2021 and 31 August 2024. The oral-site subgroup comprised 12 patients receiving ≥1 illumination to the oral cavity (tongue, gingiva, buccal mucosa, floor of mouth, hard palate, or flap). The primary endpoint was objective response rate (ORR). Secondary endpoints included time-to-treatment failure (TTF), overall survival (OS), progression-free survival (PFS), and adverse events (AEs). Kaplan–Meier analyses assessed time-to-event outcomes.</div></div><div><h3>Results</h3><div>Best overall responses comprised complete response, partial response, stable disease, and progressive disease in six, four, one, and one patients, respectively, yielding an ORR of 83.3 % (95 % confidence interval [CI], 51.6–97.9) and a disease control rate of 91.7 % (95 % CI, 61.5–99.8). The median TTF, OS, and PFS were 6.0 months (95 % CI, 1.4–18.3), 22.0 months (95 % CI, 6.0–unreached), and 6.0 months (95 % CI, 1.4–10.4), respectively. AEs included pain (100 %; grade≥3, 25 %), mucositis (92 %; grade≥3, 17 %), facial oedema (75 %), laryngeal oedema (67 %; grade≥3, 8 %), dysphagia (50 %), bleeding (50 %), and fistula (33 %). Commonly required supportive interventions included anticipatory analgesia, airway protection (e.g., preventive tracheostomy), and temporary enteral nutrition.</div></div><div><h3>Conclusions</h3><div>Oral-site PIT demonstrated high antitumour activity with frequent but manageable local toxicities, necessitating proactive, multidisciplinary supportive care. This first dedicated multicentre analysis focused on oral illumination corroborates site-specific PIT evaluation and its integration within multimodal treatment strategies.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105360"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic therapy for colorectal cancer: A bibliometric and visualization analysis (1986–2025)","authors":"Xin Wen ,&nbsp;Jiayan Liu ,&nbsp;Wenbin Zhao ,&nbsp;Xu Liu ,&nbsp;Lian Liu ,&nbsp;Zhen Zeng ,&nbsp;Danfeng Wei","doi":"10.1016/j.pdpdt.2026.105368","DOIUrl":"10.1016/j.pdpdt.2026.105368","url":null,"abstract":"<div><h3>Background</h3><div>Photodynamic therapy (PDT) has emerged as a promising minimally invasive modality for the treatment of colorectal cancer (CRC), offering localized cytotoxicity and potential immune activation. However, a comprehensive overview of the global research landscape in this field is lacking. This study aims to systematically assess the global trends, collaborative networks, influential contributors, and current research status in the use of PDT for CRC via bibliometric analysis.</div></div><div><h3>Methods</h3><div>Publications from 1986 to April 2025 were retrieved from the Web of Science Core Collection via a defined search strategy. VOSviewer and CiteSpace were employed to analyze publication trends, country and institutional networks, journal impact, citation and co-citation patterns, and keyword evolution.</div></div><div><h3>Results</h3><div>A total of 828 publications were included. Global research on PDT for CRC has increased steadily since 2015, with China and the United States being the most prolific contributors. The Chinese University of Hong Kong and the University of Chicago was prominent in terms of productivity and citation impact, respectively. <em>Photodiagnosis and Photodynamic Therapy</em> was the leading journal. Keyword and citation burst analyses revealed major research themes and mapped the overall research landscape of PDT in CRC. Enhanced endoscopic visualization has facilitated the application of PDT in CRC, improving the precision of both lesion localization and therapeutic light delivery.</div></div><div><h3>Conclusion</h3><div>PDT research for CRC is undergoing rapid expansion and increasing interdisciplinary integration. Although substantial progress has been made, its clinical translation remains at a relatively early stage. This bibliometric analysis presents the research landscape of PDT for CRC and highlights key contributors and major themes. While it offers a comprehensive overview for researchers and clinicians, it does not evaluate the validity or clinical relevance of individual studies.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105368"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized comparative study of 5-Fluorouracil 4%, tirbanibulin, and photodynamic therapy for relapsing actinic keratoses","authors":"Federico Venturi ,&nbsp;Elisabetta Magnaterra ,&nbsp;Alberto Gualandi ,&nbsp;Biagio Scotti ,&nbsp;Carlotta Baraldi ,&nbsp;Aurora Alessandrini ,&nbsp;Sabina Vaccari ,&nbsp;Emi Dika","doi":"10.1016/j.pdpdt.2026.105359","DOIUrl":"10.1016/j.pdpdt.2026.105359","url":null,"abstract":"<div><h3>Background</h3><div>Actinic keratosis (AK) reflects a field cancerization process in chronically sun-damaged skin, and relapse after diclofenac therapy is a frequent clinical scenario. Field-directed treatments such as 5-fluorouracil (5-FU), tirbanibulin, and photodynamic therapy (PDT) are widely used, yet comparative data in post-diclofenac relapse and the contribution of reflectance confocal microscopy (RCM) to therapeutic monitoring remain limited.</div></div><div><h3>Objectives</h3><div>To compare the clinical efficacy, tolerability, and subclinical response of 5-FU 4%, tirbanibulin 1%, and PDT in relapsing AK of the scalp, integrating RCM imaging to assess field response.</div></div><div><h3>Methods</h3><div>A prospective randomized (1:1:1) study was conducted in 45 patients who previously achieved complete clearance with diclofenac 3% and relapsed within 12 months. Endpoints included clinical clearance at 12 weeks, RCM normalization, recurrence at 6 months, and local skin response (LSR) severity.</div></div><div><h3>Results</h3><div>Twelve-week clearance rates were 73.3% for 5-FU, 66.7% for tirbanibulin, and 80.0% for PDT (p=0.711). RCM normalization occurred in 66.7%, 60.0%, and 73.3% of patients, respectively (p=0.741). Recurrence among responders at 6 months was low and comparable (9.1%, 10.0%, and 8.3%; p=0.991). Tirbanibulin showed significantly lower LSR scores versus 5-FU and PDT (p&lt;0.001), indicating superior tolerability.</div></div><div><h3>Conclusions</h3><div>Short-term efficacy of 5-FU, tirbanibulin, and PDT was comparable, while tolerability differed markedly. Tirbanibulin demonstrated the most favorable inflammatory and cosmetic profile, whereas 5-FU and PDT may be preferred when a more intense field effect is desired. RCM detected subclinical persistence in select cases and may serve as an adjunctive imaging tool for monitoring and guiding retreatment in field cancerization.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105359"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographic, polygonal, light-brown scales and fluorescent bright-blue margins: Characteristic dermoscopic clues for granular parakeratosis","authors":"Qi Zhang ,&nbsp;Jianfang Sun ,&nbsp;Xiaopo Wang","doi":"10.1016/j.pdpdt.2026.105375","DOIUrl":"10.1016/j.pdpdt.2026.105375","url":null,"abstract":"<div><h3>Background</h3><div>Granular parakeratosis (GP) is an uncommon dermatosis characterized by scaly, erythematous to brownish eruptions in intertriginous areas. Diagnosis is challenging and traditionally requires histological confirmation. While dermoscopy and ultraviolet-induced fluorescence dermoscopy (UVFD) offer non-invasive diagnostic approaches, their characteristic findings in GP remain inadequately defined.</div></div><div><h3>Objective</h3><div>This study aimed to systematically characterize the dermoscopic and UVFD features of GP, with a secondary aim of evaluating their diagnostic utility in differentiating GP from other intertriginous dermatoses.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 21 patients with clinicopathologically confirmed GP. Dermoscopic and UVFD data from patients with inverse psoriasis (<em>n</em> = 10), tinea cruris (<em>n</em> = 23), and erythrasma (<em>n</em> = 12) were collected for comparison. Parameters included background color, vascular morphology and distribution, scale color and distribution, and UVFD fluorescence.</div></div><div><h3>Results</h3><div>Among 21 GP patients (male: female 13:8; mean age 38.4 ± 15.2 years), 71.4% reported prior exposure to disinfectants containing benzalkonium chloride. Symmetrical, erythematous to brown patches/plaques with variable scaling were observed, predominantly in axillae (61.9%), with pruritus /burning in 71.4%. Dermoscopy revealed large, geographic, polygonal, light-brown scales. Under UVFD, 81% of GP exhibited bright-blue margins. Comparative analysis distinguished GP from inverse psoriasis (uniform red background with regular vessels), tinea cruris (peripheral scaling and distinct vascular patterns), and erythrasma (coral-red fluorescence under UVFD, also seen in 60.0% of inverse psoriasis cases).</div></div><div><h3>Conclusion</h3><div>Dermoscopy and UVFD provide reliable, non-invasive diagnostic clues for the GP. The presence of light-brown geographic scales and fluorescent bright-blue margins offers a practical, non-invasive tool for accurate GP diagnosis.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105375"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}