Photodiagnosis and Photodynamic Therapy最新文献

{"title":"In vitro study of pulp blood flow based on laser speckle contrast imaging","authors":"WangGe Xiong ,&nbsp;NengHao Xia ,&nbsp;Yuhao Yang ,&nbsp;Xingdao He ,&nbsp;Jian Yang","doi":"10.1016/j.pdpdt.2025.105227","DOIUrl":"10.1016/j.pdpdt.2025.105227","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study is to develop an ex vivo dental pulp blood flow model and assess variations in flow velocity using laser speckle contrast imaging (LSCI). Furthermore, we seek to quantitatively examine the impact of various flow rates, dentin block thicknesses, and capillary inner diameters on LSCI detection outcomes.</div></div><div><h3>Methods</h3><div>Polypropylene capillaries were inserted into 50 isolated teeth, followed by the injection of a 1 % intralipid solution into the capillaries. A coherent light source is used to illuminate the surface of the dental crown in LSCI, and the speckle images of the crown are captured by a detector at varying flow rates. The Speckle Flow Index (SFI) was computed using a time-based algorithm. A quantitative analysis was then conducted to assess the impact of flow rate, dentin thickness, and capillary diameter on the LSCI detection outcomes.</div></div><div><h3>Results</h3><div>Utilizing the time-based algorithm, SFI values were determined for 50 isolated teeth across various flow rates, and there were significant differences between SFI values at different flow rates (p&lt;0.05). Quantitative analysis further revealed a robust positive correlation between flow velocity and SFI value, a pronounced negative correlation between total dentin thickness and SFI value, and a negative correlation between capillary diameter and SFI value.</div></div><div><h3>Conclusion</h3><div>LSCI demonstrates the capability to detect alterations in blood flow velocity within an in vitro dental pulp blood flow model, showcasing its significant potential for clinical application in assessing dental pulp vitality.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105227"},"PeriodicalIF":2.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of corneal higher-order aberrations and topographic patterns of effective optical zone at five years after FS-LASIK and SMILE for myopia","authors":"Jie Qin ,&nbsp;Jiayu Li ,&nbsp;Yushan Xu ,&nbsp;Ran Gao ,&nbsp;Bingqing Li ,&nbsp;Yu Han ,&nbsp;Fengju Zhang","doi":"10.1016/j.pdpdt.2025.105225","DOIUrl":"10.1016/j.pdpdt.2025.105225","url":null,"abstract":"<div><h3>Introduction</h3><div>To assess corneal higher-order aberrations (HOAs) at five years after femtosecond laser-assisted in situ keratomileusis (FS-LASIK) and small incision lenticule extraction (SMILE) for myopia, and to investigate correlative factors of myopic regression combined with morphology of effective optical zone (EOZ).</div></div><div><h3>Methods</h3><div>Data of 116 and 126 eyes receiving FS-LASIK and SMILE were collected in this cross-sectional study at five years postoperative, including refractive outcome, corneal topography, HOAs, epithelial thickness (ET), and Quality of Vision (QoV) questionnaire. Basing on the morphology of EOZ, curvature maps were classified into uniform, bowtie, semicircular, keyhole, and irregular patterns.</div></div><div><h3>Results</h3><div>FS-LASIK group demonstrated greater spherical aberration of total and anterior cornea at 4 and 6 mm than SMILE group (<em>P</em> &lt; 0.050). Compared to uniform group (55.37 %), semicircular group (19.42 %) exhibited greater anterior and posterior horizontal coma at 6 mm (<em>P</em> &lt; 0.050), the former was associated with horizontal decentration (<em>r</em>=-0.723, <em>P</em> &lt; 0.050). Keyhole group (10.33 %) tended to have more negative spherical aberration of total and anterior cornea at 4 mm (<em>P</em> &lt; 0.050) and more obvious focusing difficulties (<em>P</em> &lt; 0.050). In high myopia patients, keyhole pattern showed a 21.323-folds probability of myopic regression compared to uniform pattern (<em>P</em> &lt; 0.050). For every 1 μm increase in the discrepancy between central and pericentral ET, the possibility of myopic regression increased by 29.3 % (<em>P</em> &lt; 0.050).</div></div><div><h3>Conclusions</h3><div>SMILE seemed to offer advantages in less HOAs than FS-LASIK. To improve visual quality for high myopia patients, it is essential to focus on centration to achieve regular EOZ, as well as monitoring epithelial remodeling to prevent myopic regression.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105225"},"PeriodicalIF":2.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent lesion distribution after photodynamic therapy for recurrent respiratory papillomatosis","authors":"Yufei Pan ,&nbsp;Huili Huang ,&nbsp;Ke Wu ,&nbsp;Xiao Han ,&nbsp;Huiying Hu ,&nbsp;Kai Liu ,&nbsp;Yuanyuan Lu ,&nbsp;Zhenkun Yu","doi":"10.1016/j.pdpdt.2025.105223","DOIUrl":"10.1016/j.pdpdt.2025.105223","url":null,"abstract":"<div><h3>Background</h3><div>Recurrent respiratory papillomatosis (RRP) is a benign laryngeal tumor, and traditional surgical resection faces the dilemma between excessive tissue removal and high recurrence rates. Photodynamic therapy (PDT), as a \"regional clearance\" strategy, offers a novel approach to addressing this challenge. However, the anatomical distribution of recurrent lesions following PDT has not been fully elucidated.</div></div><div><h3>Objective</h3><div>To evaluate the distribution characteristics of recurrent lesions in different anatomical regions following PDT for RRP, thereby providing evidence to optimize PDT treatment protocols.</div></div><div><h3>Methods</h3><div>A retrospective study analyzed 43 RRP patients who underwent PDT (January 2021-December 2024), with 54 recurrence records examined. Postoperative laryngoscopic examinations were performed monthly to assess recurrence. An 11-region anatomical diagram was used to assess lesion distribution and calculate relative recurrence rates across anterior and posterior regions. In-situ and ectopic recurrences were statistically compared.</div></div><div><h3>Results</h3><div>The study found that the epiglottis exhibited the highest relative recurrence rate (75.00 %), indicating it is more prone to recurrence than other regions (<em>χ²</em> = 21.850, <em>P</em> = 0.016). Additionally, the recurrence rate in the posterior regions (63.16 %) was higher than that in the anterior regions (50.00 %) (<em>χ²</em> = 3.54, <em>P</em> = 0.060). Furthermore, in-situ recurrence significantly outweighed ectopic recurrence (<em>χ²</em> = 111.24, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>During PDT for RRP, statistically significant differences in relative recurrence rates were observed across anatomical regions, with in-situ recurrence being the most common pattern.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105223"},"PeriodicalIF":2.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic therapy in conjunction with Mohs micrographic surgery for basal cell carcinoma: A scenario-based review","authors":"Kevin Varghese,&nbsp;Natalie Behzadpour,&nbsp;Lauren Randall,&nbsp;Atieh Jibbe","doi":"10.1016/j.pdpdt.2025.105220","DOIUrl":"10.1016/j.pdpdt.2025.105220","url":null,"abstract":"<div><h3>Background</h3><div>Basal cell carcinoma (BCC) is the most common skin cancer. Mohs micrographic surgery (MMS) offers the highest cure rates for high-risk or recurrent BCC, while photodynamic therapy (PDT) is effective for superficial and select nodular BCC. Reports describing their combined use are limited and heterogeneous.</div></div><div><h3>Objective</h3><div>To summarize clinical scenarios in which PDT has been used in conjunction with MMS for BCC and describe reported oncologic and cosmetic outcomes.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed, Embase, and Scopus was performed to identify English-language studies reporting PDT with MMS for BCC. Eligible studies included patients treated with PDT before, during, or after MMS. Data extracted included tumor characteristics, PDT protocol, timing relative to MMS, outcomes, and adverse events. Due to substantial heterogeneity, results were narratively synthesized by clinical scenario.</div></div><div><h3>Results</h3><div>Eight studies met inclusion criteria, comprising case reports, case series, and retrospective analyses. PDT was applied preoperatively to debulk tumors, postoperatively to treat residual superficial disease, postoperatively to enhance wound healing, or in special populations such as patients with nevoid basal cell carcinoma syndrome. Across studies, recurrence rates did not significantly differ from MMS alone where assessed. Cosmetic outcomes were variably reported, with high patient satisfaction frequently noted. Adverse effects were generally mild and transient.</div></div><div><h3>Conclusion</h3><div>Evidence for PDT combined with MMS is limited to small, heterogeneous studies. Current data support selective use in specific scenarios, but further prospective, controlled studies with standardized outcome measures are needed to clarify its role in clinical practice.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105220"},"PeriodicalIF":2.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study on autologous split-thickness skin graft combined with photodynamic therapy for the treatment of keloid in the female pubic region","authors":"Wenyan Zhu ,&nbsp;Xiaoyan Wu ,&nbsp;Xuyan Weng ,&nbsp;Xiaodong Yao ,&nbsp;Xiaomei Cui ,&nbsp;Mulan Fu ,&nbsp;Xiaodong Chen","doi":"10.1016/j.pdpdt.2025.105222","DOIUrl":"10.1016/j.pdpdt.2025.105222","url":null,"abstract":"<div><h3>Objective</h3><div>Keloid, marked by abnormal fibroblast activity and excessive collagen buildup, presents a therapeutic challenge due to their high recurrence rates. The pubic region, a sensitive anatomical area, is rarely discussed in keloid treatment literature. Our study demonstrates that autologous split-thickness skin grafting combined with topical photodynamic therapy(PDT) effectively prevents the recurrence of keloids in pubic region by radically eliminating inflammation and inhibiting fibroblast proliferation.</div></div><div><h3>Methods</h3><div>This study retrospectively analyzed 32 keloid patients treated with autologous split-thickness skin grafting and photodynamic therapy (surgery+PDT group) and compared them to a control group of 29 patients who underwent surgery alone (surgery only group). The improvement rate was evaluated at baseline (month 0) and at a 12-month follow-up (month 12) using the modified Vancouver Scar Scale (mVSS) and the Patient and Observer Scar Assessment Scale (POSAS)</div></div><div><h3>Results</h3><div>The study involved 61 patients. Both treatment groups exhibited significant enhancements in mVSS and POSAS scores; however, the combination therapy group showed a statistically significant improvement in POSAS scores at 12 months compared to the surgery-only group.</div></div><div><h3>Conclusion</h3><div>Patients receiving both surgery and PDT showed a significantly higher improvement rate compared to those undergoing surgery alone.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105222"},"PeriodicalIF":2.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of lamina cribrosa thickness and optic disc vascular density in diabetic retinopathy","authors":"Doruk Can SEVÜK ,&nbsp;Ferhat Baver Polat ,&nbsp;Hüseyin Emek ,&nbsp;Çimen Baran ,&nbsp;Seyfettin Erdem ,&nbsp;Sedat Ava ,&nbsp;Uğur Keklikçi","doi":"10.1016/j.pdpdt.2025.105219","DOIUrl":"10.1016/j.pdpdt.2025.105219","url":null,"abstract":"<div><h3>Introduction</h3><div>To determine whether optic disc vascular density correlates with lamina cribrosa thickness and depth in diabetic retinopathy (DR).</div></div><div><h3>Materials Method</h3><div>A total of 85 participants, 30 controls (Group-1), 30 with nonproliferative DR (NPDR=Group-2) and 25 with proliferative DR (PDR=Group-3) were included in this prospective study. Detailed ophthalmologic examinations were performed, optic disc vascular density by optical coherence tomography angiography (OCTA), retinal nerve fiber thickness by OCT, lamina cribrosa thickness and depth by enhanced depth imaging OCT (EDI-OCT), prelaminar tissue thickness, and Bruch's membrane openings were measured and recorded. Groups were compared with ANOVA <em>t</em>-test and the relationship between the parameters was evaluated with Spearman's correlation analysis.</div></div><div><h3>Results</h3><div>No statistically significant difference was found between the groups in terms of age and gender (p=0.741, p=0.922, respectively). In EDI-OCT, lamina cribrosa depth was significantly decreased in groups 2 and 3 (p&lt;0.001). No statistically significant difference was observed between the groups in terms of lamina cribrosa thickness (p=0.115). Prelaminar tissue thickness was significantly thinner in Groups 2 and 3 (p&lt;0.001). Bruch's membrane opening was significantly higher in Groups 2 and 3 (p=0.001). It was observed that the percentage of vascular density was significantly decreased in the inside disc, peripapillary, whole optic disc and inferior hemi in the groups with DR compared to healthy subjects (p&lt;0.001), while the percentage of vascular density in the inside disc and whole optic disc images was correlated with proliferation. Retinal nerve fiber thickness and lamina cribrosa depth were significantly negatively correlated (r:-0.228 p=0.036).</div></div><div><h3>Conclusion</h3><div>There was no correlation between diabetic retinopathy and lamina cribrosa thickness. However, there was a correlation between lamina cribrosa depth, prelaminar tissue thickness and Bruch's membrane opening. By performing these correlated measurements in EDI-OCT in diabetic patients, information about whether optic disc vascularity is affected can be obtained.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105219"},"PeriodicalIF":2.6,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of corneal curvature and astigmatism measured in myopic eyes by Pentacam, Sirius and IOLMaster 700","authors":"Han Song ,&nbsp;Wei Yang ,&nbsp;Jiani Wei ,&nbsp;Xixi Wang","doi":"10.1016/j.pdpdt.2025.105218","DOIUrl":"10.1016/j.pdpdt.2025.105218","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare and evaluate the correlation and agreement of three different anterior segment analysis systems in measuring corneal curvature and astigmatism among healthy myopic subjects.</div></div><div><h3>Methods</h3><div>This study recruited myopic patients between Jan 2021 and Dec 2023 (252 myopia patients in total). After obtaining informed consent, corneal curvature and astigmatism were measured using the Pentacam, Sirius, and IOLMaster 700 anterior segment analysis systems. The degree and axis of astigmatism were incorporated into the Fourier vector formula to calculate vertical/horizontal astigmatism(J0) and oblique astigmatism in the 45°direction(J45) values. Statistical analyses were performed to assess the differences, correlations, and consistencies of the measurement results obtained from the three devices.</div></div><div><h3>Results</h3><div>No significant differences were observed in flat corneal curvature(Kf), steep corneal curvature(Ks), mean corneal curvature(Km), and J0 values measured by the Pentacam, Sirius, and IOLMaster 700 devices (<em>p</em> <em>&gt;</em> 0.05). However, a significant difference was noted in J45 values (<em>p</em> <em>&lt;</em> 0.05), J45 measured by IOLMaster 700 is significantly lower than that measured by Pentacam and Sirius. The mean values of Kf, Ks, Km, J0, and J45 measured by the three devices exhibited positive correlations (<em>p</em> <em>&lt;</em> 0.001). Bland-Altman analysis demonstrated good consistency for Kf, Ks, Km, J0, and J45 measurements across the three instruments.</div></div><div><h3>Conclusions</h3><div>The mean values of Kf, Ks, Km, J0, and J45 measured by the three anterior segment analysis systems are positively correlated and demonstrate good agreement. However, there are significant differences in J45 values, this difference may affect the axial evaluation of astigmatism, and attention should be paid to the specificity when measuring oblique astigmatism, and suggesting that the same device should be selected for evaluation and follow-up in practical clinical work.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105218"},"PeriodicalIF":2.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes of refraction and visual quality after ray-tracing guided FS-LASIK in Chinese high myopia versus low-to-moderate myopia","authors":"Yuyan Huang ,&nbsp;Jiayu Li ,&nbsp;Fengju Zhang ,&nbsp;Yanzheng Song ,&nbsp;Yushan Xu ,&nbsp;Yixin Zhang ,&nbsp;Yuxin Yang ,&nbsp;Linlu Zhang ,&nbsp;Jie Wen","doi":"10.1016/j.pdpdt.2025.105216","DOIUrl":"10.1016/j.pdpdt.2025.105216","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the changes of refraction and visual quality after ray-tracing guided femtosecond laser-assisted in situ keratomileusis (FS-LASIK) in Chinese high myopia (HM) compared to that of low-to-moderate myopia (LM).</div></div><div><h3>Methods</h3><div>38 eyes in the HM group and 34 eyes in the LM group were evaluated 6 months after ray-tracing guided FS-LASIK. The InnovEyes Sightmap device was used to acquire high-order aberrations and generate individualized 3D eye model ablation profile. The Quality of Vision and Ocular Surface Disease Index questionnaires were used to evaluate the subjective visual quality and dry eye syndrome, respectively.</div></div><div><h3>Results</h3><div>In the HM group, postoperative MRSE demonstrated an alternation from 0.19 ± 0.53 D at 1 month to 0.06 ± 0.35 D at 6 months (<em>P</em> = 0.029). Similar tendency of MRSE was observed in the LM group, changing from 0.23 ± 0.33 D to 0.04 ± 0.32 D (<em>P</em> &lt; 0.001). Visual symptoms gradually alleviated with time, especially the frequency and the severity of blurred vision (<em>P</em> = 0.007 and 0.018). None of the participants reported the bothersome of halos 6 months postoperatively. 80.95% of participants reported no dry eye discomfort 6 months after surgery. No correlations were found between preoperative MRSE and the postoperative subjective visual symptoms (all <em>P</em> &gt; 0.050). Greater spherical aberration (SA) decrease at 6-mm pupil size was correlated to lower level of starburst (<em>coef</em> = 2.40, <em>P</em> = 0.046).</div></div><div><h3>Conclusions</h3><div>Ray-tracing guided FS-LASIK demonstrated comparable efficacy and visual quality in HM compared to LM. The decline in SA may contributed to the relief of subjective visual complaints, especially the starbursts in high myopia.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105216"},"PeriodicalIF":2.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripapillary OCTA metrics in diabetic retinopathy patients with varying bevacizumab exposure: A cross-sectional study","authors":"Farideh Mousavi ,&nbsp;Salar Nikmanesh ,&nbsp;Amin Arasteh ,&nbsp;Amir Tarkavani ,&nbsp;Amir Eftekhari Milani ,&nbsp;Peyman Ghodraty","doi":"10.1016/j.pdpdt.2025.105217","DOIUrl":"10.1016/j.pdpdt.2025.105217","url":null,"abstract":"<div><h3>Objective</h3><div>To compare optic nerve head (ONH) microvasculature and retinal nerve fiber layer (RNFL) thickness of diabetic retinopathy (DR) patients with varying numbers of intravitreal bevacizumab (IVB) injections to non-diabetic controls via optical coherence tomography angiography (OCTA).</div></div><div><h3>Methods</h3><div>It is a cross-sectional study of 246 eyes of 145 patients in 4 groups: group A: healthy control subjects (53 eyes); group B: DR without any IVB treatment (103 eyes); group C: DR one week after their first IVB injection (42 eyes); and group D: DR which received at least 9 IVB injections for the past year (48 eyes). All the included eyes underwent ONH OCTA using the AngioVue system, and the peripapillary vessel density (VD) and RNFL thickness were evaluated.</div></div><div><h3>Results</h3><div>60 males and 85 females with a median age of 64.0 years were included in the study. The groups were not different in terms of age or sex. Groups C and D presented significantly lower peripapillary VDs than the controls (49.6 % and 48.9 % vs. 53.0 %, respectively, <em>p</em> &lt; 0.001). The peripapillary VD was lower in treatment-naïve DR cases than in controls, but this difference was not statistically significant (51.4 % vs. 53.0 %). The whole-image VD was lower in group B than in group A (47.8 % vs. 49.6 %, <em>p</em> = 0.007); however, when the comparison was limited to mild to moderate DRs, the difference was insignificant (<em>p</em> = 0.949). Although the peripapillary VD was lower in group D cases than in group B cases (48.9 % vs. 51.4 %, <em>p</em> = 0.020), the subgroup analysis of severe NPDR patients in groups B, C, and D revealed no significant differences among the three groups in terms of peripapillary VD. However, the nasal segment VD was significantly lower in IVB-treated cases than in treatment-naïve cases. In addition, among treatment-naïve cases, the PDR cases had lower nasal VD than the mild NPDR cases. The RNFL thickness was not significantly different among the four groups (<em>p</em> = 0.256).</div></div><div><h3>Conclusion</h3><div>Diabetic retinopathy and anti-VEGF treatment could reduce the peripapillary VD, which seems to happen primarily in the nasal segment and becomes evident in more advanced stages of DR. However, the frequency of IVB injections might not affect the peripapillary microvasculature.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105217"},"PeriodicalIF":2.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Evaluation of topical photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA) for cervical intraepithelial neoplasia with human papillomavirus (HPV) infection: a retrospective comparative study versus loop electrosurgical excision procedure (LEEP)” [Photodiagnosis Photodyn Ther. (2025);54:104697]","authors":"Jue Li ,&nbsp;Ying Huang ,&nbsp;Jinxin Tao ,&nbsp;Hangli Yang ,&nbsp;Hua Zhu","doi":"10.1016/j.pdpdt.2025.104764","DOIUrl":"10.1016/j.pdpdt.2025.104764","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104764"},"PeriodicalIF":2.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}