Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Optical coherence tomography angiography study on retinochoroidal thickness and blood flow changes after posterior scleral reinforcement surgery","authors":"Yongqi Mao ,&nbsp;Hao Chen ,&nbsp;Yunhua Tang ,&nbsp;Haoming Geng ,&nbsp;Fuwen Zhang","doi":"10.1016/j.pdpdt.2025.104628","DOIUrl":"10.1016/j.pdpdt.2025.104628","url":null,"abstract":"<div><h3>Purpose</h3><div>Based on optical coherence tomography angiography (OCTA), we investigate the effects of posterior scleral reinforcement surgery on the fundus structure and function in patients with high myopia.</div></div><div><h3>Methods</h3><div>Retrospective clinical study. Forty cases (41eyes) of high myopia patients who underwent posterior scleral reinforcement surgery at Chengdu University of Traditional Chinese Medicine Affiliated Silver Eye Hospital from January 2022 to January 2025 were selected. Follow-up periods included postoperative 3 months, 6 months, and 1 year. Key indicators before and after surgery were compared, including best-corrected visual acuity (BCVA), axial length (AL), spherical equivalent (SE), retinal thickness (RT), choroidal thickness (CT), and Superficial retinal capillary plexus density (SCP), deep retinal capillary plexus density (DCP), choroidal vascularity index (CVI), choroidal stromal vascularity index (CSI).</div></div><div><h3>Results</h3><div>The study included 40 patients (41 eyes), comprising 9 male patients (9 eyes) and 31 female patients (32 eyes), with a mean age of 42.05 ± 18.71 years.At the last follow-up, patients showed significantly shortened AL (<em>P</em> &lt; 0.001), significantly improved BCVA (<em>P</em> &lt; 0.05), and significantly increased CT (<em>P</em> &lt; 0.05).SCP also exhibited significant postoperative increases (<em>P</em> &lt; 0.05). Additionally,CVI and CSI showed significant postoperative elevation (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This study demonstrates that posterior scleral reinforcement achieves axial stabilization through mechanical reinforcement, mitigates vitreous traction forces on the retina and choroid, enhances visual acuity, improves choroidoretinal microcirculation, and optimizes fundus architecture.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104628"},"PeriodicalIF":3.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro effects of laser-activated irrigation methods on apical extrusion of indocyanine green mediated photodynamic therapy","authors":"Behnam Bolhari ,&nbsp;Naghmeh Meraji ,&nbsp;Rahim Seddighi ,&nbsp;Yashar Safaraei ,&nbsp;Nasim Chiniforush","doi":"10.1016/j.pdpdt.2025.104626","DOIUrl":"10.1016/j.pdpdt.2025.104626","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to compare the effects of different laser-activated irrigation (LAI) methods on apical extrusion of indocyanine green (ICG).</div></div><div><h3>Materials and Methods</h3><div>In this in vitro study, 40 extracted single-canal premolars were instrumented and randomly assigned to 4 groups (<em>n</em> = 10) of (I) ICG (1 mg/mL) + photon-induced photoacoustic streaming (PIPS) with 2940 nm erbium laser, 20 mJ energy, and 50 µs pulse width for 30 s, (II) ICG + shockwave enhanced emission photoacoustic streaming (SWEEPS) with 2940 nm erbium laser with 20 mJ energy, and 50 µs pulse width (two 25 µs pulse widths) for 30 s, (III) ICG + 810 nm diode laser with 250 mW power for 30 s, and (IV) ICG without activation. Photoluminescence (PL) was used to quantify the ICG volume extruded through the apex, and determine the excitation wavelength of the ICG samples. To calibrate the PL results, one random ICG sample underwent inductively-coupled plasma (ICP) test to quantify the sulfur content of the extruded ICG. Considering the chemical formulation of ICG, the concentration of extruded ICG was calculated accordingly. Data were analyzed by one-way ANOVA (alpha=0.05).</div></div><div><h3>Results</h3><div>The best spectrum was obtained at 390 nm excitation wavelength with 700 V voltage and slit number=10. The study groups had no significant difference in the concentration of apically extruded ICG (<em>P</em> = 0.611).</div></div><div><h3>Conclusion</h3><div>The tested LAI protocols had no significant difference with each other or with the no activation protocol regarding the apical extrusion of ICG.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104626"},"PeriodicalIF":3.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear and non-linear association of chronic kidney disease with retina and choroid vessel density in diabetes: a prospective study","authors":"Lijian Fang ,&nbsp;Ruiheng Zhang ,&nbsp;Suoqing Zhuang ,&nbsp;Lei Wang ,&nbsp;Qiuping Wang ,&nbsp;Yong Huang ,&nbsp;Mingli Wang ,&nbsp;Yu Feng ,&nbsp;Min Xiao ,&nbsp;Chunyuan Zhou ,&nbsp;Lili Wu ,&nbsp;Sihan Zhang ,&nbsp;Lili Xue ,&nbsp;Tong Tian ,&nbsp;Yuanyuan Li ,&nbsp;Bing Cao ,&nbsp;Huaiyu Hao","doi":"10.1016/j.pdpdt.2025.104625","DOIUrl":"10.1016/j.pdpdt.2025.104625","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the association of retinal and choroidal vessel density with renal function using optical coherence tomographic angiography (OCTA).</div></div><div><h3>Method</h3><div>The present study prospectively recruited consecutive diabetes patients admitted to Beijing Liangxiang Hospital from October 2023 to March 2024. All participants underwent comprehensive ophthalmologic examinations and laboratory analysis at the first visit. Quantitative parameters of OCTA scans included retinal superficial vascular complex (SVC) and deep vascular complex (DVC) vessel densities, and choriocapillaris flow deficits (CCFD%).</div></div><div><h3>Results</h3><div>A total of 85 patients were included in the present study. After adjusting for severity of diabetic retinopathy and other confounding factors, every 1 % increased SVC within in ETDRS grid was associated with reduced incidence of CKD (OR=0.86 95 %CI:[0.73–1.01]), decreased urine albumin-to-creatinine ratio (ACR, coefficient=-0.65, 95 %CI:[-1.22, -0.08]), and increased eGFR (coefficient=1.55, 95 %CI:[0.14, 2.96]). Every 1 % increased CCFD% was significantly associated with increased incidence of CKD (OR=1.72, 95 %CI:[1.14–2.58]) and decrease eGFR (coefficient=-6.47, 95 %CI:[-9.68, -3.26]). Non-linear regression revealed that SVC vessel density was associated with eGFR among patients with advanced retinal microvasculature damage.</div></div><div><h3>Conclusions</h3><div>Retina and choroid blood flow were associated with the onset and severity of CKD. Decreased SVC and decreased CCFD% can be used for non-invasively screening CKD in diabetes patients.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104625"},"PeriodicalIF":3.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Raman spectroscopy assisted diagnosis and photodynamic therapy efficacy evaluation of actinic keratosis: Case report","authors":"Rongyi Zhu ,&nbsp;Shiyi Yang ,&nbsp;Na Yu ,&nbsp;Rongjun Zhang ,&nbsp;Minfeng Wu","doi":"10.1016/j.pdpdt.2025.104624","DOIUrl":"10.1016/j.pdpdt.2025.104624","url":null,"abstract":"<div><div>Actinic keratosis (AK), a precancerous skin lesion with malignant potential, demands timely diagnosis and effective treatment monitoring. Aminolevulinic acid photodynamic therapy (ALA-PDT) is the recommended treatment for AK, but there is currently a lack of methods to evaluate the effectiveness of treatment. Raman spectroscopy might be a promising tool for non-invasive diagnosis of AK and dynamic detection of PDT efficacy. This article reports a 77-year-old female patient with AK who received Raman spectroscopy detection and successful PDT. Utilizing a portable Raman spectrometer, distinct spectral features were identified: Raman band at 1688 cm⁻¹, attributed to elastin accumulation in AK lesions, and Raman band at 1615 cm⁻¹, associated with tyrosine, a melanin precursor. The patient underwent three sessions of ALA-PDT and Raman spectra were acquired after each session to reveal progressive changes in peak intensities. The findings demonstrate Raman spectroscopy’s dual potential: non-invasive diagnosis via elastin-related biomarkers and real-time efficacy evaluation of PDT through tyrosine-associated spectral changes, offering molecular specificity and dynamic monitoring without invasive procedures.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104624"},"PeriodicalIF":3.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgery combined with endoscopic photodynamic therapy for simultaneous double primary early carcinomas of the esophagus and cardia: a case report","authors":"Zhu-Xin Chen,&nbsp;Hao Chen,&nbsp;Hong Wei,&nbsp;Ling Chen,&nbsp;Guo-Qing Shi","doi":"10.1016/j.pdpdt.2025.104616","DOIUrl":"10.1016/j.pdpdt.2025.104616","url":null,"abstract":"<div><h3>Background</h3><div>Known as double primary cancers or duplicated cancers, are the simultaneous occurrence of two or more primary malignancies with different histological type. The location and stage of each tumor determine the degree of complexity of treatment. Conventional methods pose great difficulties since a single modality is usually inadequate to reach total eradication.</div></div><div><h3>Case Summary</h3><div>This paper addresses a 66-year-old male patient diagnosed with an esophageal tumor whose presence had been observed for more than one month without any particular symptoms or signs. The patient presented an unusual example of dual primary early carcinoma involving the cardia and the upper esophagus. Given single-modality techniques were insufficient for total eradication, the tumor in the upper esophagus, which was proximally to the neck, presented special difficulties for conventional treatment. We followed a thorough treatment schedule combining endoscopic photodynamic therapy with surgical resection. With no appreciable disease progression or complications noted over a 32-month follow-up period, this strategy produced good clinical results.</div></div><div><h3>Conclusion</h3><div>In this case, surgical intervention and photodynamic therapy worked well, providing new optionsfor treating similar clinical situations.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104616"},"PeriodicalIF":3.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palpebral Bowen’s disease: a report of two cases successfully treated with photodynamic therapy","authors":"Sabina Vaccari ,&nbsp;Alice N. Rossi ,&nbsp;F. Pepe ,&nbsp;F. Cassini ,&nbsp;M. Roda ,&nbsp;Emi Dika","doi":"10.1016/j.pdpdt.2025.104622","DOIUrl":"10.1016/j.pdpdt.2025.104622","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) has been shown to be a safe and highly effective treatment for Bowen’s disease. We report two cases of patients with palpebral Bowen’s disease successfully treated with PDT. Although surgery remains the preferred treatment for challenging sites such as the periocular area, PDT in select cases may represent a good therapeutic option.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104622"},"PeriodicalIF":3.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of small incision Lenticule extraction and Transepithelial photorefractive keratectomy in terms of visual quality and accommodation in Myopic patients","authors":"Yunfei Han ,&nbsp;Yangyang Liu ,&nbsp;Beibei Xu ,&nbsp;Lihua Zhang ,&nbsp;Linlin Xu","doi":"10.1016/j.pdpdt.2025.104619","DOIUrl":"10.1016/j.pdpdt.2025.104619","url":null,"abstract":"<div><h3>Background</h3><div>To investigate the differences of surgical results, visual quality and accommodative function between small incision lenticule extraction (SMILE) and transepithelial photorefractive keratectomy (tPRK).</div></div><div><h3>Methods</h3><div>Prospective study analyzing 279 eyes of 143 myopic patients. Included 71 patients 140 eyes undergoing SMILE and 72 patients 139 eyes undergoing tPRK. Measures included visual acuity, refractive error, total and corneal higher order aberrations (HOAS), and accommodative function at baseline and 1 and 3 months postoperatively.</div></div><div><h3>Results</h3><div>At 3 months postoperatively, both SMILE and tPRK demonstrated comparable safety and efficacy profiles. The safety index (SI) was 1.19 ± 0.18 for SMILE versus 1.15 ± 0.15 for tPRK (<em>P</em> = 0.12), while the efficacy index (EI) showed 1.24 ± 0.19 for SMILE versus 1.22 ± 0.18 for tPRK (<em>P</em> = 0.12). Notably, SMILE induced greater vertical coma aberrations and trefoil aberrations compared to tPRK, regardless of pupil diameter. Despite this, total higher-order aberrations (HOAs) decreased in the SMILE group but increased in the tPRK group, though the inter-group difference was not statistically significant (<em>P</em> = 0.16). Regarding accommodative function, both procedures improved postoperative parameters. At 1 month, SMILE demonstrated superior performance in relative accommodation (PRA) and monocular accommodative amplitude (MMA) compared to tPRK (<em>P</em> &lt; 0.05 for both). No statistically significant differences were observed in other parameters between the groups at any follow-up time point.</div></div><div><h3>Conclusion</h3><div>Both SMILE and tPRK are effective and safe for correcting mild to high myopia. SMILE induces more corneal aberrations but shows earlier enhancement of accommodative reserve compared to tPRK.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104619"},"PeriodicalIF":3.1,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical efficacy of intravascular laser irradiation of blood (ILIB): A narrative review of randomized controlled trial","authors":"Leonardo Díaz ,&nbsp;Alain Chaple Gil ,&nbsp;Alfredo Von Marttens ,&nbsp;Javier Basualdo ,&nbsp;Claudio Sotomayor ,&nbsp;Alexis Vera Becerra ,&nbsp;Víctor Beltrán ,&nbsp;Gilbert Jorquera ,&nbsp;Rodrigo Caviedes ,&nbsp;Eduardo Fernández","doi":"10.1016/j.pdpdt.2025.104618","DOIUrl":"10.1016/j.pdpdt.2025.104618","url":null,"abstract":"<div><h3>Background</h3><div>Intravascular Laser Irradiation of Blood (ILIB) is a systemic application of photobiomodulation therapy (PBMT), proposed to modulate oxidative stress, inflammation, and mitochondrial function. Although its clinical use is expanding across various medical conditions, a consolidated evaluation of its therapeutic relevance remains lacking.</div></div><div><h3>Objective</h3><div>This review aimed to synthesize available evidence from randomized controlled trials (RCTs) on the clinical efficacy and safety of ILIB, with particular focus on outcomes related to pain, inflammation, oxidative stress, and quality of life.</div></div><div><h3>Methods</h3><div>a narrative literature review guided by PRISMA principles and the PROPS contextual framework. Eight RCTs involving 340 participants were identified through searches in five electronic databases and gray literature. Studies were eligible if they investigated ILIB—via intravascular or transcutaneous application—and reported clinical or biochemical outcomes compared to sham, placebo, or standard care.</div></div><div><h3>Results</h3><div>Eight RCTs comprising 340 participants were included, addressing conditions such as cardiovascular disease, diabetic neuropathy, osteoarthritis, spinal cord injury, chronic endometritis, cellulite, and pediatric dental anxiety. ILIB demonstrated consistent reductions in pain (30–55 %), inflammatory cytokines (e.g., IL-6, TNF-α), and oxidative stress markers, along with significant improvements in mitochondrial activity and quality-of-life indicators (SF-36, WOMAC). No serious adverse events were reported. RoB analysis indicated four studies with low risk and four with some concerns.</div></div><div><h3>Conclusions</h3><div>ILIB appears to be a safe and promising intervention with systemic biological effects and multidimensional clinical benefits. Future clinical research should prioritize standardized dosimetry protocols and long-term, patient-centered outcomes to guide broader integration into evidence-based care.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104618"},"PeriodicalIF":3.1,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delving into transfer learning within U-Net for refined retinal vessel segmentation: An extensive hyperparameter analysis","authors":"G. Prethija ,&nbsp;Jeevaa Katiravan","doi":"10.1016/j.pdpdt.2025.104620","DOIUrl":"10.1016/j.pdpdt.2025.104620","url":null,"abstract":"<div><div>Blood vessel segmentation poses numerous challenges. Firstly, blood vessels often lack sufficient contrast against the background, impeding accurate differentiation. Additionally, the overlapping nature of blood vessels complicates separating individual vessels. Moreover, variations in the thickness of vessels and branching structures further augment complications to the segmentation process. These hurdles demand robust algorithms and techniques for effective blood vessel segmentation in medical imaging applications. The U-Net and its alternates have demonstrated exceptional performance related to conventional traditional Convolutional Neural Network (CNN). This study proposes a novel approach for retinal vessel segmentation through transfer learning. We proposed models such as VGG16 U-Net, VGG19 U-Net, ResNet50 U-Net, MobileNetV2 U-Net and DenseNet121 U-Net that employ pretrained models as encoders in U-Net architecture. We investigated the performance of pretrained models on DRIVE datasets with the optimizers Adam, Stochastic Gradient Descent <strong>(</strong>SGD) and RMSProp. The results revealed that models with Adam optimizer have shown better results. The evaluated results demonstrated that ResNet50 U-Net achieved the highest specificity of 0.9875, MobileNetV2 U-Net achieved a recall of 0.8056 and DenseNet121 U-Net attained an accuracy of 0.9689. VGG16 U-Net and MobileNetV2 U-Net have attained a dice coefficient of 0.849.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104620"},"PeriodicalIF":3.1,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canal disinfectants: Potassium titanyl phosphate laser, magnesium oxide nanoparticles, and aloe-emodin PDT on smear layer removal and bond strength of glass fiber post to root dentin","authors":"Mai Mohammed Alhamdan","doi":"10.1016/j.pdpdt.2025.104615","DOIUrl":"10.1016/j.pdpdt.2025.104615","url":null,"abstract":"<div><h3>AIM</h3><div>To assess the influence of different root canal disinfectants i.e., Potassium titanyl phosphate laser (KTPL), Aloe-emodin (AE) mediated Photodynamic therapy (PDT), Magnesium oxide (MgO) nanoparticles (NPs) on smear layer (SL) removal and push out bond strength (PBS) of Glass fiber post (GFP) to the canal dentin.</div></div><div><h3>MATERIAL AND METHOD</h3><div>Forty-eight extracted premolars, having a single root and a solitary canal were included. A root canal procedure was performed on each tooth and subsequently, post-space preparation was executed using peeso-reamers leaving approximately 4 mm of gutta percha in the canal. According to the type of disinfection used the samples were categorized into 4 groups (<em>n</em> = 11). Group 1 (2.5 % NaOCl + EDTA), Group 2 (KTPL+ EDTA), Group 3 (AE mediated PDT+ EDTA), and Group 4 (MgONPs+ EDTA). Cementation of fiber posts was performed using a self-adhesive resin cement. Scanning electron microscope (SEM) assessed the SL removal from the canals (<em>n</em> = 2). Failure mode and PBS were assessed with a stereomicroscope and universal testing machine respectively(<em>n</em> = 10). One-way analysis of variance and Tukey posthoc test at p-value  ≤ 0.05 were used to compare the mean scores of PBS and SL removal.</div></div><div><h3>RESULT</h3><div>The cervical region in Group 4 (MgONPs + EDTA) samples showed the highest PBS scores (10.41±0.38 MPa) and the maximum level of SL removal (1.55±0.10). Conversely, Group 3 at the apical third of the root (AE mediated PDT ₊EDTA) displayed the least efficacy for SL removal (2.81±0.09) and lowest PBS(7.69±0.19 MPa).</div></div><div><h3>CONCLUSION</h3><div>MgO nanoparticles, when paired with Ethylenediaminetetraacetic acid as a final irrigant, offer a promising alternative to conventional root canal sterilants.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104615"},"PeriodicalIF":3.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}