Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Early history of clinical application of photosensitizing drugs in photodynamic therapy (PDT) of portwine stain (PWS) birthmarks","authors":"Kaihua Yuan ,&nbsp;Zheng Huang","doi":"10.1016/j.pdpdt.2024.104383","DOIUrl":"10.1016/j.pdpdt.2024.104383","url":null,"abstract":"<div><div>It has been known for two decades that vascular acting PDT can be used as an alternative in the treatment of portwine stain (PWS) birthmarks. The modality is only used in China at the moment and an expert consensus has been published this year. A recent review article in Lasers in Surgery and Medicine summarized the available evidence based on PubMed records of PWS treatment using pulsed dye laser (PDL) and HMME-PDT. The authors observed that HMME-PDT has emerged as the first choice for PWS treatment, particularly for young children, in many major hospitals in China. The authors also raised questions on ethics of several Chinese reports. This correspondence addresses these questions and meanwhile explains the early history of clinical application of photosensitizing drugs in PWS PDT in China.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104383"},"PeriodicalIF":3.1,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of anti-viral photodynamic therapy effects of different concentrations of 5-ALA using light irradiation on HSV-1","authors":"Farhad Farzaneh ,&nbsp;Masoud Parsania ,&nbsp;Mitra Sadeghpour Natanzi ,&nbsp;Negar Parsania ,&nbsp;Mohammad Amin Salehi ,&nbsp;Sepehr Fekrazad ,&nbsp;Hamed Bagheri ,&nbsp;Reza Fekrazad","doi":"10.1016/j.pdpdt.2024.104365","DOIUrl":"10.1016/j.pdpdt.2024.104365","url":null,"abstract":"<div><h3>Background</h3><div>Herpes simplex virus (HSV) infections are prevalent worldwide, posing challenges due to asymptomatic carriage and recurrent outbreaks. Conventional treatments, including antiviral medications, are limited by drug resistance. Photodynamic therapy (PDT) offers a promising alternative, leveraging photosensitizers to induce viral inactivation via reactive oxygen species (ROS) generation upon light activation.</div></div><div><h3>Methods</h3><div>This study investigates the efficacy of 5-aminolevulinic acid (5-ALA) as a photosensitizer in antiviral PDT against HSV-1. HSV-1 was treated with varying concentrations of 5-ALA and subjected to light irradiation at a 630 nm wavelength. Virus titers were assessed using the 50 % Tissue Culture Infectious dose (TCID50) assay. Six experimental groups were used: [<span><span>1</span></span>] Control (no 5-ALA or light), HSV-1 with 0.05 g/ml 5-ALA and 630 nm light, [<span><span>2</span></span>] HSV-1 with 0.05 g/ml 5-ALA (no light), [<span><span>3</span></span>] HSV-1 with 0.1 g/ml 5-ALA and light, [<span><span>4</span></span>] HSV-1 with 0.1 g/ml 5-ALA (no light), and [<span><span>5</span></span>] HSV-1 with light (no 5-ALA).</div></div><div><h3>Results</h3><div>Virus treatment with 0.1 g/ml 5-ALA combined with light irradiation significantly reduced HSV-1 titer compared to control groups (<em>p</em> &lt; 0.05). Specifically, the virus titer decreased from 10 ^6.3 TCID50/ml in the control group to 10 ^4.5 TCID50/ml in the treated group. However, lower concentrations of 5-ALA or light irradiation alone did not yield significant reductions in HSV-1 titer (<em>p</em> &gt; 0.05). Group 4, receiving 0.1 g/ml 5-ALA with light irradiation, exhibited a significantly greater reduction in virus titer than group 2, receiving 0.05 g/ml 5-ALA with light irradiation (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>5-ALA-mediated PDT demonstrates selective antiviral efficacy against HSV-1, particularly at higher concentrations coupled with light irradiation. These findings underscore the potential of 5-ALA-based PDT as a promising approach for HSV-1 treatment, especially in cases of drug-resistant strains and immunocompromised individuals. Optimization of dosage and treatment protocols is essential for maximizing effectiveness in clinical applications, highlighting the need for further research in this area.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104365"},"PeriodicalIF":3.1,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of riboflavin, nanocurcumin, and hydrogen peroxide under light conditions: Reduction of mature dental biofilms and enamel mineral loss","authors":"Shima Afrasiabi ,&nbsp;Ahmed Qays Khudhur AL． Gburi ,&nbsp;Ladan Ranjbar Omrani ,&nbsp;Nasim Chiniforush ,&nbsp;Zohreh Moradi","doi":"10.1016/j.pdpdt.2024.104379","DOIUrl":"10.1016/j.pdpdt.2024.104379","url":null,"abstract":"<div><h3>Background</h3><div>Biofilms are a potential harbor for many microorganisms. The aim of this study was to test the efficacy of riboflavin (Rib), nano-micelle curcumin (NC), and hydrogen peroxide (HP), alone and in combination with the respective light (light-emitting diode (LED) or 980 nm diode laser) on the reduction of <em>Streptococcus mutans</em> and <em>Lactobacillus acidophilus</em> dual-species biofilms and their effect on the enamel mineral loss.</div></div><div><h3>Materials and methods</h3><div>The biofilms were formed on saliva-coated enamel slabs. Then, the biofilms were treated with antimicrobial photodynamic therapy (PDT) based on LED, Rib, and NC photosensitizers and with HP also based on a 980 nm diode laser (<em>n</em> = 8 per group). A crystal violet assay was performed to determine the reduction of the dual-species biofilms. The enamel slabs were analyzed for calcium and phosphorus content by scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX).</div></div><div><h3>Results</h3><div>While HP-PDT showed a reduction of 37% (<em>p</em> &lt; 0.001), PDT with NC resulted in an even greater reduction of dual-species biofilms (40%, <em>p</em> &lt; 0.001) than HP- and Rib-mediated PDT. In the EDX test, no significant difference was found between the control group and the treatment groups.</div></div><div><h3>Conclusions</h3><div>The use of natural photosensitizers such as NC in PDT has an effect that may be potentially important in reducing caries-causing bacteria.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104379"},"PeriodicalIF":3.1,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of central serous retinopathy in pilots and non-pilot patients","authors":"Yan-Yan Zhao,&nbsp;Hua Wang,&nbsp;Wei Chen,&nbsp;Quan Wang,&nbsp;Yong Liu","doi":"10.1016/j.pdpdt.2024.104376","DOIUrl":"10.1016/j.pdpdt.2024.104376","url":null,"abstract":"<div><h3>Background</h3><div>Central serous chorioretinopathy (CSC) is a disqualifying condition for pilots because of the importance of good vision to their jobs. The objective of this study was to evaluate the clinical diagnosis, treatment, and aviation medical assessment principles for CSC in military pilots.</div></div><div><h3>Methods</h3><div>The clinical data and aviation medical assessments of 15 pilots with CSC who were admitted to the Air Force Medical Center between January 2003 and December 2021 were analyzed, and three typical cases were reported. The relevant literature evaluation was conducted on 32 non-pilot patients with CSC.</div></div><div><h3>Results</h3><div>The mean age of the 15 pilots was 37.47 ± 4.21 years, and they were all male. Fourteen were affected in a single eye (4 in the right eye and 10 in the left eye), while one was affected in both eyes. Two pilots were nonsmokers and did not consume alcohol; one was a smoker; four pilots consumed alcohol on a regular basis; and eight pilots were smokers and consumed alcohol on a regular basis. The mean best-corrected visual acuity (BCVA) increased from 0.83 ± 0.33 at the initial visit to 0.95 ± 0.44 at the final visit. The non-pilot group included 32 patients, 29 of whom were male and 3 of whom were female, with a mean age of 37.16 ± 10.02 years. Thirty-one patients had single-eye involvement (17 of the right eye and 14 of the left eye), while one patient had involvement of both eyes. Seventeen patients were nonsmokers and did not consume alcohol; two were smokers; four consumed alcohol on a regular basis; and nine were smokers and consumed alcohol on a regular basis. The mean BCVA increased from 0.64 ± 0.28 at the first visit to 0.90 ± 0.30 at the final visit. Patients in the pilot group had a high recurrence rate, which was associated with a low final BCVA and led to their disqualification from flying.</div></div><div><h3>Conclusion</h3><div>Pilot and non-pilot patients did not differ significantly in terms of CSC clinical data. Chronic and recurrent CSC can be a vision-threatening disease; therefore, pilots must receive accurate and timely diagnosis.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104376"},"PeriodicalIF":3.1,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical features and perfusion density in paracentral acute middle maculopathy by optical coherence tomography angiography study","authors":"Zhengfeng Liu ,&nbsp;Xuemei Pan ,&nbsp;Dan Wang ,&nbsp;Yingying Zou ,&nbsp;Peipei Liu ,&nbsp;Ying Wang ,&nbsp;Hongsheng Bi ,&nbsp;Xiaofeng Xie","doi":"10.1016/j.pdpdt.2024.104380","DOIUrl":"10.1016/j.pdpdt.2024.104380","url":null,"abstract":"<div><h3>Purpose</h3><div>To observe the clinical features of the paracentral acute middle maculopathy (PAMM) and to investigate the changes in perfusion density of superficial capillary plexus (SCP) and deep capillary plexus (DCP) in PAMM by optical coherence tomography angiography (OCTA).</div></div><div><h3>Methods</h3><div>Twelve patients (12 eyes) diagnosed with PAMM and 13 healthy participants (13 eyes) were enrolled. The clinical features of 12 PAMM patients were recorded. The perfusion density of SCP and DCP in the parafovea and perifovea (divided into Temporal, Superior, Nasal, and Inferior) was measured by OCTA in PAMM and healthy eyes. Automated macular maps, including SCP and DCP, were also performed.</div></div><div><h3>Results</h3><div>The mean age of patients was 48.08 (range 14–72) years. The best corrected visual acuity (BCVA) was from finger count (FC) to 1.0. Risk factors included hypertension, diabetes mellitus, COVID-19, etc. The patients had signs of retinal vascular disease except for one patient with isolated PAMM. A spectral-domain OCT image of the PAMM eye showed hyperreflectivity in the inner nuclear layer (INL). Compared with healthy eyes, SCP and DCP in PAMM eyes were significantly reduced in all sectors (all <em>p</em> &lt; 0.05) in the parafovea and perifovea. The average perfusion density of SCP in parafovea and perifovea in PAMM eyes were 46.94±4.34% vs 52.21±3.98 % (<em>p</em> = 0.002), 44.01±3.95% vs 50.51±3.14 (<em>p</em> = 0.000) in healthy eyes. The average perfusion density of DCP in parafovea and perifovea in PAMM eyes were 51.22±4.16% vs 57.15±3.87 % (<em>p</em> = 0.002), 47.375±6.23% vs 54.27±5.33 % (<em>p</em> = 0.002) in healthy eyes.</div></div><div><h3>Conclusion</h3><div>PAMM often accompanies concurrent ocular and systemic diseases. OCTA results confirm that the perfusion density of SCP and DCP in the parafovea and perifovea significantly reduced in PAMM patients.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104380"},"PeriodicalIF":3.1,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current trends and available evidence on low-level laser therapy for osteoradionecrosis: A scoping review","authors":"Larissa Di Carvalho Melo ,&nbsp;Bruna Bastos Silveira ,&nbsp;Mylene Martins Monteiro ,&nbsp;Juliana Amorim dos Santos ,&nbsp;Elaine Barros Ferreira ,&nbsp;Paula Elaine Diniz Reis ,&nbsp;Camila de Barros Gallo ,&nbsp;Eliete Neves Silva Guerra","doi":"10.1016/j.pdpdt.2024.104381","DOIUrl":"10.1016/j.pdpdt.2024.104381","url":null,"abstract":"<div><h3>Background</h3><div>This scoping review explored current trends and available evidence in Low-Level Laser Therapy (LLLT) in the treatment and prevention of osteoradionecrosis.</div></div><div><h3>Methods</h3><div>The search strategy was conducted in MEDLINE/PubMed, EMBASE, Web of Science, and grey literature on January 15, 2024, without language or time restrictions.</div></div><div><h3>Results</h3><div>19 studies were included. The application of LLLT protocols was 58 % for therapeutic use, 21 % for preventive use, and 21 % for a combination of both. Regarding the use of antimicrobial photodynamic therapy (aPDT), 41 % of the studies employed this technique, which utilized methylene blue as the photosensitizer. For treatments associated with photobiomodulation, 57 % reported pharmacological treatment, 29 % surgical treatment, 11 % prescribed chlorhexidine mouthwashes, and 4 % other therapies. <em>In vivo</em> studies used diode lasers emitting low incident power densities in the near-infrared wavelength (67 %) at 780 to 904 nm. In comparison, case reports also used diode lasers emitting low incident power densities in the red and near-infrared wavelength (64 %) at 660 to 904 nm. The continuous emission mode was utilized in 83 % of <em>in vivo</em> studies and 17 % of the case reports. None of the studies included in this review reported all laser parameters.</div></div><div><h3>Conclusions</h3><div>In general, studies suggested that LLLT can be used for therapeutic and preventive applications in the management of osteoradionecrosis. However, clinical studies are case reports and the variability in laser parameters across the included studies poses challenges for establishing standardized treatment protocols. The lack of comprehensive data on laser parameters underscores the need for future research to focus on standardizing LLLT protocols and conducting well-designed, large-scale clinical trials. This approach will help to better evaluate the effectiveness of LLLT and potentially integrate it more reliably into clinical practice.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104381"},"PeriodicalIF":3.1,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of aminolevulinic acid photodynamic therapy combined with antibiotics on Mycobacterium abscessus skin infections: An in vitro and in vivo study","authors":"Xiaoyu Wang ,&nbsp;Xiao Wang ,&nbsp;Zhenyu Kou ,&nbsp;Kedai Sun ,&nbsp;Yang Tan ,&nbsp;Jinyi Chen ,&nbsp;Yang He ,&nbsp;Wen Ding ,&nbsp;Hong Liu ,&nbsp;Yi Liang ,&nbsp;Lingfei Li ,&nbsp;Xia Lei","doi":"10.1016/j.pdpdt.2024.104371","DOIUrl":"10.1016/j.pdpdt.2024.104371","url":null,"abstract":"<div><h3>Background</h3><div><em>Mycobacterium abscessus</em> skin infections have emerged as a major medical issue. Traditional antibiotic treatments are challenging, prolonged, and often lead to recurrence, creating an urgent need for new therapies. This study investigates the effectiveness of aminolevulinic acid photodynamic therapy (ALA-PDT) combined with antibiotics in treatmenting <em>M. abscessus</em>, using both <em>in vitro</em> and <em>in vivo</em> methods.</div></div><div><h3>Methods</h3><div>We treated eight patients with <em>M. abscessus</em> skin infections following cosmetic surgery, using ALA-PDT (ALA concentration: 20 %; red light: 80 J/cm²) combined with oral or intravenous antibiotics,including clarithromycin, moxifloxacin and amikacin, to treat 8 patients with <em>M. abscessus</em> skin infection after medical cosmetic surgery, and assessed the treatment outcomes. Additionally, four bacterial strains (MAB-A1, MAB-A2, MAB-B1, and MAB-B2) isolated from patients were tested <em>in vitro</em> for ALA-PDT efficacy to determine the optimal ALA-PDT dosage. Furthermore, the strains’ single colony morphology, biofilm formation, and genome characteristics of were analyzed to explore the factors influencing ALA-PDT's bactericidal effects. Finally, a combined ALA-PDT and antibiotics sterilization experiment was conducted <em>in vitro</em>.</div></div><div><h3>Results</h3><div>Clinically, ALA-PDT combined with antibiotics showed strong efficacy in treating <em>M. abscessus</em> skin infections, with no recurrence observed during follow-up. <em>In vitro</em>, ALA-PDT effectively killed <em>M. abscessus</em>, although MAB-B1 and MAB-B2 required a higher ALA-PDT dose compared with MAB-A1 and MAB-A2. Compared to MAB-A1 and MAB-A2, MAB-B1 and MAB-B2 exhibited stronger biofilm formation capabilities and bacterial virulence as well as genome mutations primarily affecting fatty acid synthesis and metabolism, potentially explaining their increased ALA-PDT dosage requirement. Notably, the combination of ALA-PDT and antibiotics exerted markedly higher bactericidal effects <em>in vitro</em> compared with antibiotics alone.</div></div><div><h3>Conclusions</h3><div>ALA-PDT combined with antibiotics emerged as an effective treatment for <em>M. abscessus</em> skin infections. However, optimal dosage and antibiotic combinations should be tailored to the characteristics of specific clinical strains.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104371"},"PeriodicalIF":3.1,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Folliculotropic mycosis fungoides of the face successfully treated combining CO2 laser and conventional photodynamic therapy (c-PDT)","authors":"Biagio Scotti ,&nbsp;Bianca Maria Piraccini ,&nbsp;Alessandro Pileri","doi":"10.1016/j.pdpdt.2024.104377","DOIUrl":"10.1016/j.pdpdt.2024.104377","url":null,"abstract":"<div><div>A 57-year-old male with a three-year history of folliculotropic mycosis fungoides (FMF), previously treated systemically, received CO2 laser-assisted photodynamic therapy (PDT) following the recurrence of FMF on the face. The procedure involved a CO2 laser (SmartXide DOT Deka) and the photosensitizing agent methyl aminolevulinate (MAL) (METVIX 160 mg/g Cream, Galderma Medical), in conjunction with a red light-emitting diode lamp (Aktilite CL128, Galderma, wavelength 630 nm). The primary endpoint was the clinical remission of the lesions; the secondary one the evaluation of treatment tolerance, measured using the 11-point (0–10) Numeric Rating Scale (NRS) for burning/pain, heat, and swelling. After a single treatment session and four weeks of follow-up, the patient's facial lesions achieved complete clinical remission.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104377"},"PeriodicalIF":3.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofluorescence imaging system (BIS) Guided surgery for MRONJ: A Case Series on the Preservation of Teeth and Implants","authors":"Sang-Hee Park ,&nbsp;Yesel Kim ,&nbsp;Hong-Cheol Yoon ,&nbsp;Pil-Young Yun ,&nbsp;Jeong-Kui Ku","doi":"10.1016/j.pdpdt.2024.104370","DOIUrl":"10.1016/j.pdpdt.2024.104370","url":null,"abstract":"<div><div>The decision of surgical margin for Medication-Related Osteonecrosis of the Jaw (MRONJ) surgery is challenging. Recently, a method involving biofluorescence imaging system (BIS) has been reported for its application in MRONJ surgery to live detection of pathologic bone tissue from vital bone, which cannot be distinguished during conventional surgery. This case series aimed to assess the outcomes of adjacent teeth and implants near the lesion site in MRONJ patients who underwent BIS-guided MRONJ surgery. This retrospective study was assessed the radiographic and clinical outcomes of seven patients who underwent MRONJ surgery with BIS guidance but chose not to remove adjacent teeth or implants near the lesion. A total of seven patients (1 male, 6 females, 77.2 ± 4.7 years) were included in the study. Four implants and four teeth adjacent to the lesion were preserved. Over an average duration of 8.7 months, all subjects exhibited normal soft tissue healing and function without any complications. In conclusion, the BIS guided MRONJ surgery can be considered a minimally invasive and effective approach.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104370"},"PeriodicalIF":3.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical indocyanine green antimicrobial photodynamic therapy for refractory feline chronic gingivostomatitis: A case report","authors":"Chien Ju Hou ,&nbsp;Tzu Ying Chen ,&nbsp;Tak-Wah Wong","doi":"10.1016/j.pdpdt.2024.104373","DOIUrl":"10.1016/j.pdpdt.2024.104373","url":null,"abstract":"<div><div>Feline chronic gingivostomatitis (FCGS) is a painful and severe inflammatory mucosal disease in cats that presents significant challenges in treatment. This case study describes a novel approach for a cat with FCGS that was unresponsive to antibiotics, non-steroidal anti-inflammatory drugs, and dental extraction. The cat exhibited rapid improvement after undergoing oral indocyanine green (ICG)-mediated antimicrobial photodynamic therapy (aPDT); however, treatment was discontinued due to an episode of anaphylaxis. Subsequent oral aminolevulinic acid (ALA)-mediated aPDT proved ineffective over nine sessions. The cat was then treated with a topical approach using ICG-aPDT. ICG was prepared by dissolving 5 mg of powder in 3 mL of sterile water, which was applied to the oral gingiva, followed by irradiation with an 810 nm diode laser, delivering a total fluence of 16.8 <em>J</em>/cm² per session through the skin in two divided doses. The cat underwent biweekly aPDT, totaling 13 treatment sessions without any adverse events over four months. Gradual weight gain was observed from the first treatment. During the three-year follow-up, there was no recurrence of FCGS. This case report highlights the potential efficacy of topical ICG-aPDT as a treatment modality for FCGS.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104373"},"PeriodicalIF":3.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}