Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Quantitative analysis of retinal and choroidal microvascular changes after endonasal endoscopic pituitary adenoma resection: An OCTA study","authors":"Liu Chen ,&nbsp;Linhao Wang ,&nbsp;Yonggang Wu ,&nbsp;Ning Li ,&nbsp;Lin Lin ,&nbsp;Xiaolong Li ,&nbsp;Yunxian Gao ,&nbsp;Yong Zhao","doi":"10.1016/j.pdpdt.2025.104639","DOIUrl":"10.1016/j.pdpdt.2025.104639","url":null,"abstract":"<div><h3>Background</h3><div>This study used swept-source optical coherence tomography angiography (SS-OCTA) to compare retinal and choroidal vascular parameter changes before and after transsphenoidal surgery in pituitary adenoma (PA) patients, and to compare these changes with healthy controls, in order to evaluate its predictive value for visual recovery and determine the optimal timing for surgery.</div></div><div><h3>Methods</h3><div>23 PA patients (46 eyes) and 25 healthy volunteers (50 eyes) were included. The PA group was followed up at 1 week and 1 month postoperatively. Retinal and choroidal parameters in the macula(M) area and optic nerve head(ONH) area were assessed, including thickness(T), volume(V), vascular flow density (VFD), foveal avascular zone (FAZ), choroidal vascular volume (CVV) and choroidal vascular index (CVI).</div></div><div><h3>Results</h3><div>Comparison of retinal and choroidal morphology and blood flow between the case group and the control group showed significant increases in the deep capillary plexus (DCP) thickness and volume in the macula. The superficial capillary plexus (SCP) thickness, volume, large and medium choroidal vessels (LMCV) CVI (<em>p</em> = 0.032) in the optic disc area, as well as all indicators of the FAZ were significantly reduced. Compared to preoperative values, a week postoperatively, SCP-T and SCP-V in the optic disc area, and DCP FAZ perimeter all significantly decreased, while SCP VFD in the foveal avascular zone within 300 μm (FAZ300) significantly increased (<em>p</em> = 0.047). Compared to preoperative values, 1 month postoperatively, LMCV choroidal matrix density (CSI), CVI (<em>p</em> = 0.022) and DCP-T in the optic nerve area significantly decreased, while SCP-FAZ300 significantly increased (<em>p</em> = 0.0282). Tumor size was the most important factor affecting retinal and choroidal parameters.</div></div><div><h3>Conclusion</h3><div>The SCP-T, CSI, CVI, and other parameters in PA patients were significantly lower compared to healthy controls. These parameters further decreased after decompression surgery, likely due to secondary changes from optic nerve atrophy caused by tumor compression. The continulous improvement of SCP foveal avascular zone within 300 μm(FAZ300) may be related to the recovery of blood flow after the decompression, as the macular cells remain intact. These parameters—SCP-FAZ300, LMCV-CVI/CSI, and SCP-ONH T/V—collectively quantify postoperative visual acuity(VA)and visual field(VF) outcomes and guide surgical timing selection.These findings suggest that PA patients require earlier screening and treatment, and OCTA can serve as an optimal non-invasive evaluation tool.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104639"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Correlation of retinal curvature with ocular biometry in patients with myopia” [Photodiagnosis and Photodynamic Therapy 52 (2025) 104505]","authors":"Guo-Ren Xu ,&nbsp;Ming Yan ,&nbsp;Zhen Huang ,&nbsp;Ya Ye ,&nbsp;Yan-Ping Song","doi":"10.1016/j.pdpdt.2025.104605","DOIUrl":"10.1016/j.pdpdt.2025.104605","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104605"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “ALA-PDT promotes IL-1β secretion from human SZ95 sebocytes via activation of the NLRP3 inflammasome” [Photodiagnosis and Photodynamic Therapy 46 (2024) 104007]","authors":"Jian Zhang ,&nbsp;Yufeng Chang ,&nbsp;Suqing Liu ,&nbsp;Jiang Tuo ,&nbsp;Zhongyi Xu ,&nbsp;Jiayi Ying ,&nbsp;Yijian Zhu ,&nbsp;Zhengzhou Shi ,&nbsp;Christos C. Zouboulis ,&nbsp;Min Jiang ,&nbsp;Qianqian Wang ,&nbsp;Leihong Xiang","doi":"10.1016/j.pdpdt.2025.104607","DOIUrl":"10.1016/j.pdpdt.2025.104607","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104607"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Comparative analysis of optic disc and macular microvasculature in children with anisometropic amblyopia before and after treatment” [Photodiagnosis and Photodynamic Therapy volume 52 (2025) 1-10]","authors":"Jia-Hao Li ,&nbsp;Jian Zhao ,&nbsp;Chang Won Park ,&nbsp;Chen-Yu Yang ,&nbsp;Jia-Yu Ma ,&nbsp;Jing Wang ,&nbsp;Ying-Jun Li","doi":"10.1016/j.pdpdt.2025.104601","DOIUrl":"10.1016/j.pdpdt.2025.104601","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104601"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Inhibition of efflux pump encoding genes and biofilm formation by sub-lethal photodynamic therapy in methicillin susceptible and resistant Staphylococcus aureus” [Photodiagnosis and Photodynamic Therapy 102900 (2022) 102900]","authors":"Yanlan Yu ,&nbsp;Yan Zhao ,&nbsp;Yaxiong He ,&nbsp;Jiayin Pang ,&nbsp;Zengjun Yang ,&nbsp;Mengxue Zheng ,&nbsp;Rui Yin","doi":"10.1016/j.pdpdt.2025.104492","DOIUrl":"10.1016/j.pdpdt.2025.104492","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104492"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Comparative analysis of internal limiting membrane peeling versus internal limiting membrane flap insertion for treating idiopathic macular holes” [Photodiagnosis and photodynamic therapy vol. 49 (2024): 104311. doi:10.1016/j.pdpdt.2024.104311]","authors":"Xueying Ma,&nbsp;Jie Sun,&nbsp;Qiaohong Liang,&nbsp;Yuerong Kong,&nbsp;Hong Yang,&nbsp;Xiaogang Huang","doi":"10.1016/j.pdpdt.2025.104596","DOIUrl":"10.1016/j.pdpdt.2025.104596","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104596"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation and orthodontic root resorption: A systematic review and meta-analysis","authors":"Jing Yang,&nbsp;Qianqian Zhang,&nbsp;Dehua Zheng,&nbsp;Fengchun Hou","doi":"10.1016/j.pdpdt.2025.104659","DOIUrl":"10.1016/j.pdpdt.2025.104659","url":null,"abstract":"<div><h3>Objectives</h3><div>Orthodontically induced inflammatory root resorption (OIIRR) is a common adverse effect of orthodontic treatment, characterized by the reduction in root length and volume. Photobiomodulation (PBM), a non-invasive method, has gained attention for its potential in controlling OIIRR. This review aims to analyze and summarize randomized controlled trials (RCTs) to evaluate the impact of PBM on root resorption during orthodontic treatment in humans.</div></div><div><h3>Methods</h3><div>A systematic search was conducted using relevant keywords in the Cochrane Library, PubMed, EMBASE, Web of Science, and ScienceDirect for studies published up to January 2025. Studies were selected based on predefined inclusion and exclusion criteria. The Cochrane Risk of Bias tool (RoB 2) was used to assess the risk of bias in the included RCTs. A meta-analysis was performed using RevMan software (version 5.4), and subgroup analyses were conducted to identify sources of heterogeneity.</div></div><div><h3>Results</h3><div>Eight studies with a total of 185 participants were included in the analysis. The forest plot results demonstrated that LED interventions led to statistically significant improvements in root resorption (MD = –0.15, [95 % CI –0.19, –0.10], <em>p</em> &lt; 0.00001). While LLLT studies indicated a trend toward reduced root resorption, the results did not reach statistical significance (SMD = –1.69, [95 % CI –3.52, 0.14], <em>p</em> = 0.07). The overall change in root length was not statistically significant, except for the canine tooth, where a significant reduction in resorption was observed (MD = –0.49, 95 % CI [–0.95, –0.03], <em>p</em> = 0.04). Subgroup analysis indicated that a wavelength of 850 nm or longer, a fluence exposure greater than 10 J/cm², irradiance less than 25 mW/cm², treatment durations exceeding two minutes, and more than six treatment sessions were associated with a beneficial effect in reducing orthodontically induced inflammatory root resorption.</div></div><div><h3>Conclusion</h3><div>In conclusion, while photobiomodulation (PBM) appears to have a beneficial effect on orthodontically induced root resorption, the current body of evidence is limited, with a low number of studies and considerable heterogeneity. These findings are exploratory and require validation through high-quality trials with robust designs, standardized methods, and longer follow-ups.</div></div><div><h3>Registration</h3><div>PROSPERO registration number - CRD42023444677.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104659"},"PeriodicalIF":3.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid differentiation of patients with lung cancers from benign lung nodule based on dried serum Fourier-transform infrared spectroscopy combined with machine learning algorithms","authors":"Huanyu Li,&nbsp;Lixue Dai,&nbsp;Shaomei Guo,&nbsp;Hongluan Wang,&nbsp;Lei Lei,&nbsp;Jie Yu,&nbsp;Xiaoyun Li,&nbsp;Jun Wang","doi":"10.1016/j.pdpdt.2025.104653","DOIUrl":"10.1016/j.pdpdt.2025.104653","url":null,"abstract":"<div><div>Lung cancer (LC) is associated with poor 5-year survival rates when diagnosed at advanced stages. While low-dose computed tomography (LDCT) screening enables earlier detection, its high false-positive rate, primarily due to benign lung nodules (BLN), necessitates more accurate diagnostic tools. This study developed a rapid and precise LC discrimination method by integrating Fourier transform infrared (FTIR) spectroscopy of dried serum samples with machine learning algorithms. We analyzed dried serum from 58 LC patients, 37 BLN patients, and 36 healthy controls. Five machine learning models, linear discriminant analysis (LDA), support vector machine (SVM), random forest, multilayer perceptron (MLP), and LightGBM, were optimized using FTIR spectral data (1800–900 cm⁻¹ band). All algorithms successfully differentiated the three groups, with LDA achieving the highest accuracy (93.9 %). These results demonstrate that dried serum FTIR spectroscopy coupled with machine learning, particularly LDA, offers a promising approach for distinguishing LC from BLN, potentially augmenting LDCT screening to reduce unnecessary interventions.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104653"},"PeriodicalIF":3.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of Mohs micrographic surgery with or without photodynamic therapy for locally advanced basal cell carcinoma","authors":"Freddy Gahimbare ,&nbsp;Xurong Liu ,&nbsp;Jipang Zhan ,&nbsp;Yanyu Du,&nbsp;Renliang He,&nbsp;Lian Zhang","doi":"10.1016/j.pdpdt.2025.104633","DOIUrl":"10.1016/j.pdpdt.2025.104633","url":null,"abstract":"<div><h3>Background</h3><div>Locally advanced basal cell carcinoma (laBCC) is a more severe subtype of BCC, characterized by large, deeply invasive tumors that often occur in cosmetically or functionally sensitive areas. Mohs micrographic surgery (MMS) is the standard treatment, offering high cure rates through layer-by-layer excision with microscopic margin control. However, MMS alone may not entirely prevent recurrence in aggressive or infiltrative subtypes. Photodynamic therapy (PDT) is a non-invasive treatment modality that may enhance outcomes when used adjunctively. This study evaluated whether combining MMS with PDT offers advantages over MMS alone for laBCC.</div></div><div><h3>Method</h3><div>A retrospective cohort study was conducted with 63 patients diagnosed with laBCC, categorized by histological subtype into aggressive and non-aggressive groups. Patients were not randomized; they received either MMS alone or MMS followed by PDT based on clinical decision-making at treatment time. Clinical outcomes were analyzed, including recurrence, recurrence-free survival (RFS), and surgical margins.</div></div><div><h3>Results</h3><div>MMS group exhibited a low recurrence rate of 4.4 %, against 22.2 % for MMS+PDT group. Non-aggressive tumours such as superficial, nodular, and adenoid types, treated with MMS and PDT had a 16.7 % recurrence rate, compared to 25 % for aggressive tumours, including Infiltrating, Basosquamous, and morphea form types. This suggests that non-aggressive cases may respond better to PDT. Additionally, the mean recurrence-free survival(mRFS) time was about 54 months (95 % CI: 50- 57.3 months) for non-aggressive tumours, while aggressive tumours had a mean survival of 52.3 months (95 % CI: 51–56.2 months), indicating a potential trend favouring non-aggressive tumours.</div></div><div><h3>Conclusion</h3><div>MMS combined with PDT show favourable outcomes in non-aggressive BBC.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104633"},"PeriodicalIF":3.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of erosive pustular dermatosis of the scalp using aminolevulinic acid photodynamic therapy: A report of 2 cases","authors":"Yumeng M. Li,&nbsp;Fabrizio Galimberti","doi":"10.1016/j.pdpdt.2025.104656","DOIUrl":"10.1016/j.pdpdt.2025.104656","url":null,"abstract":"<div><div>Erosive pustular dermatosis (EPD) of the scalp is an inflammatory condition that is characterized by skin atrophy, erosions, and keratotic crusts and primarily affects elderly patients. The lesions of EPD develop over time and can lead to scarring alopecia. There are no established clinical guidelines or consensus on treatment for EPD, but some authors report success with photodynamic therapy using aminolevulinic acid as the sensitizer (ALA-PDT). This report presents 2 cases of male patients, 91 and 86 years of age, with EPD that did not resolve despite prior treatment with topical steroids or retinoids but was successfully treated using ALA-PDT. In both patients, ALA-PDT resulted in improvement of EPD of the scalp after 2 sessions, with visible progress by 6 weeks after the second ALA-PDT session. The ALA-PDT treatments were well tolerated. The cases presented here demonstrate that ALA-PDT can be a potential therapeutic option for EPD of the scalp.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104656"},"PeriodicalIF":3.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}