Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Posterior pole shape and its association with axial length and high myopia","authors":"Ze-xu Wang ,&nbsp;Bin Wei ,&nbsp;Yi-chong Duan ,&nbsp;Dan-na Zhang ,&nbsp;Xiaorong Wu ,&nbsp;Qin Gong ,&nbsp;Rui Li","doi":"10.1016/j.pdpdt.2026.105526","DOIUrl":"10.1016/j.pdpdt.2026.105526","url":null,"abstract":"<div><h3>Purpose</h3><div>To quantify retinal curvature as a geometric descriptor of posterior pole configuration and to evaluate association with axial length and high myopia.</div></div><div><h3>Methods</h3><div>This dual-center observational study included 142 participants (284 eyes). Retinal curvature was derived from three-dimensional reconstruction of the Bruch’s membrane surface using wide-field swept-source optical coherence tomography angiography after axial length–based magnification correction. Curvature was summarized across predefined macular regions. Eye-level associations of high myopia (HM) and axial length with retinal curvature were evaluated using generalized estimating equations adjusted for age, sex, and imaging center. Interocular analyses were performed using linear regression models relating interocular axial length differences (ΔAL) to corresponding differences in retinal curvature.</div></div><div><h3>Results</h3><div>In eye-level analyses, HM was associated with lower RC5 (β = −0.041; 95% CI, −0.071 to −0.012; q = 0.021), RC6 (β = −0.088; 95% CI, −0.114 to −0.063; q &lt; 0.001), and superior retinal curvature (RCS; β = −0.066; 95% CI, −0.097 to −0.035; q &lt; 0.001). Per 1-mm greater axial length, lower values were observed for RC5 (β = −0.026; 95% CI, −0.038 to −0.014; q &lt; 0.001), RC6 (β = −0.046; 95% CI, −0.058 to −0.033; q &lt; 0.001), RCS (β = −0.030; 95% CI, −0.043 to −0.018; q &lt; 0.001), and RCT (β = −0.019; 95% CI, −0.032 to −0.006; q = 0.014). In interocular analyses, ΔAL was positively associated with ΔRC3 (β = 0.120; 95% CI, 0.079 to 0.160; q &lt; 0.001) and ΔRCS (β = 0.041; 95% CI, 0.007 to 0.075; q = 0.026), but inversely associated with ΔRC6 (β = −0.087; 95% CI, −0.127 to −0.048; q &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Retinal curvature provides a region-specific geometric characterization of posterior pole configuration. In myopic eyes, curvature demonstrates spatially heterogeneous associations with axial length and high myopia, with more pronounced variation in outer regions. These findings support the use of curvature-based metrics to describe spatial variation in posterior pole geometry.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"59 ","pages":"Article 105526"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148059306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Retinal doughnut”: A characteristic analysis of the retinal large Gaussian curvature annular region","authors":"Jingying Liu ,&nbsp;Guoren Xu ,&nbsp;Zhen Huang ,&nbsp;Ming Yan ,&nbsp;Ya Ye ,&nbsp;Yanping Song","doi":"10.1016/j.pdpdt.2026.105532","DOIUrl":"10.1016/j.pdpdt.2026.105532","url":null,"abstract":"<div><h3>Purpose</h3><div>To quantitatively analyze the characteristics of the retinal large Gaussian curvature annular region (RLCA) in myopic patients using ultra-widefield swept-source optical coherence tomography (SS-OCT).</div></div><div><h3>Methods</h3><div>Patients with myopia underwent 24 mm × 20 mm macular OCTA, and retinal curvature (RC) maps were generated. Key RLCA parameters, mean radius (r_mean) and radial distance (R) from the maximum RC point (RCmax) to the fovea, were quantified and correlated with axial length (AL), RCmax, and central macular retinal curvature (RCc).</div></div><div><h3>Results</h3><div>A total of 68 patients (136 eyes) were included in this study. The r_mean exhibited a significant negative correlation with both RCmax and RCc. In contrast, no statistically significant correlation was observed between the r_mean and AL. Furthermore, R showed significant negative correlations with AL, RCmax, and RCc. Notably, r_mean was strongly and positively correlated with R. Additionally, RCmax demonstrated a significant negative correlation with AL but a significant positive correlation with RCc.</div></div><div><h3>Conclusions</h3><div>The retinal morphology in the “retinal doughnut” region may be associated with the inherent morphological development of the eye to a large extent. Specifically, the smaller eyes exhibited larger RCc and RCmax values along with a smaller r_mean, whereas the larger eyes showed the opposite pattern. Nevertheless, AL may be associated with local morphological changes within this region, which are mainly reflected in the RCmax area.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"59 ","pages":"Article 105532"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148102420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"5-Aminolevulinic Acid photodynamic therapy treats HPV-associated diseases by promoting M1 macrophage polarization through STEAP3/p53/SLC7A11-mediated ferroptosis","authors":"Rui Xu ,&nbsp;Aijia Ding ,&nbsp;Bichun Xu ,&nbsp;Jing Shen ,&nbsp;Junpeng Li ,&nbsp;Hui Liu ,&nbsp;Yuan Deng ,&nbsp;Youfan Zhang ,&nbsp;Yue Zheng ,&nbsp;Kang Zeng","doi":"10.1016/j.pdpdt.2026.105523","DOIUrl":"10.1016/j.pdpdt.2026.105523","url":null,"abstract":"<div><h3>Background</h3><div>Human papillomavirus (HPV) infection is a major driver of various malignancies, accounting for approximately 90% of cervical cancer cases and 70% of oropharyngeal cancer cases worldwide, yet therapies for persistent lesions remain limited. 5-aminolevulinic acid photodynamic therapy (ALA-PDT) eliminates HPV-infected cells via reactive oxygen species (ROS)-mediated apoptosis and immune modulation, but its immune regulatory mechanisms remain undefined.</div></div><div><h3>Methods</h3><div>Macrophage polarization and ferroptosis were characterized through quantitative polymerase chain reaction (qPCR) analysis of phenotype markers, quantification of lipid peroxidation (MDA), ROS, and Bodipy-based fluorescence imaging. Transcriptomic profiling was employed to delineate ferroptosis-associated pathways underlying macrophage polarization. The STEAP3/p53/SLC7A11 axis was validated by Western blot (WB) and qPCR. The effects of macrophage-conditioned medium on HPV16-positive SiHa cells were evaluated using a CCK-8 assay and a Transwell migration assay.</div></div><div><h3>Results</h3><div>ALA-PDT triggered macrophage M1 polarization with upregulated pro-inflammatory markers and induced macrophage ferroptosis, evidenced by elevated ferroptosis markers. Transcriptomic analysis revealed activation of ferroptosis pathways (STEAP3, p53, SLC7A11) in PDT-treated macrophages. Ferrostatin-1, a ferroptosis inhibitor, reversed PDT-induced reduction of M1 polarization. Conditioned medium from PDT-treated macrophages significantly reduced the relative metabolic activity and migration of SiHa cells.</div></div><div><h3>Conclusion</h3><div>ALA-PDT induces ferroptosis-dependent macrophage M1 polarization via the STEAP3/p53/SLC7A11 axis, potentiating macrophage-mediated elimination of HPV-infected cells. This ferroptosis-immunity interplay not only disrupts viral persistence but also provides a therapeutic paradigm to overcome HPV-driven immune suppression.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"59 ","pages":"Article 105523"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148007718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertransmission as a biomarker for predicting postoperative microstructure and function of idiopathic macular hole","authors":"Huifang Yue ,&nbsp;Yuexin Shi ,&nbsp;Zeqi Fan ,&nbsp;Ximei Zhang","doi":"10.1016/j.pdpdt.2026.105516","DOIUrl":"10.1016/j.pdpdt.2026.105516","url":null,"abstract":"<div><h3>Purpose</h3><div>To observe choroidal hypertransmission in idiopathic macular hole (IMH) before and after surgery using spectral-domain optical coherence tomography (SD-OCT), and to assess its correlation with retinal microstructure and visual outcomes to determine whether hypertransmission can serve as a biomarker for predicting IMH prognosis.</div></div><div><h3>Methods</h3><div>This retrospective, observational study included patients diagnosed with IMH at Shanxi Eye Hospital between January 2019 and December 2020, who successfully achieved hole closure after vitrectomy, and had complete follow-up data. SD-OCT was used to assess baseline and postoperative retinal structures, and best-corrected visual acuity (BCVA) was recorded. The follow-up time was 3–52 months.</div></div><div><h3>Results</h3><div>Fifty-four eyes (53 patients) were enrolled. On preoperative SD-OCT, 41 eyes (75.9 %) showed hypertransmission, with no differences in duration, MH stage, base diameter, pre- and postoperative BCVA, or restoration of the external limiting membrane (ELM) and ellipsoid zone (EZ) between patients with and without preoperative hypertransmission (<em>p</em> &gt; 0.05). With or without hypertransmission on postoperative SD-OCT were 17 and 37 eyes showed significant differences in duration (<em>p</em> = 0.001), base diameter (<em>p</em> = 0.001), and baseline BCVA (<em>p</em> = 0.029), as well as in the intraoperative inner limiting membrane procedure (<em>p</em> = 0.012) and tamponade (<em>p</em> = 0.021). Multivariate regression analysis showed that only base diameter was associated with postoperative hypertransmission (<em>p</em> = 0.024, odds ratio [OR] = 1.004, 95 %CI 1.001–1.008). The ELM (17/20) and EZ (17/51) lines in 17 eyes with postoperative hypertransmission were not restored at the final follow-up.</div></div><div><h3>Conclusions</h3><div>Larger base diameter, poorer retinal microstructure, and visual acuity were associated with postoperative hypertransmission, indicating its potential as a biomarker for poor prognosis in patients with IMH.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"59 ","pages":"Article 105516"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precise staging of diabetic retinopathy through machine learning analysis of leakage source characteristics: A Radiomics-driven approach integrating OCT-A and FFA","authors":"Esmat Ramezanzadeh ,&nbsp;Hoda Zare ,&nbsp;Naser Shoeibi ,&nbsp;Mohammad Hossein Moattar ,&nbsp;Mehrdad Motamed Shariati ,&nbsp;Maryam Dourandeesh ,&nbsp;Mohammad Hossein Bahreyni Toosi ,&nbsp;Meysam Tavakoli","doi":"10.1016/j.pdpdt.2026.105522","DOIUrl":"10.1016/j.pdpdt.2026.105522","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Evaluating retinal fundus image for diabetic retinopathy (DR) assessment is used to reduce the risk of blindness among diabetic patients. To do this, DR staging is one of the challenging tasks in screening DR that includes the assessment of disease severity or progression. We introduce a novel Radiomics and machine learning algorithm (MLA) framework that analyzes localized vascular leakage sources in Optical coherence tomography angiography (OCT-A) images, using fundus fluorescein angiography (FFA) as reference, to noninvasively stage DR. By extracting 23 optimized features from leakage-prone regions and employing X-Gradient (XGboost), Adaptive Boost, and Multilayer Perceptron (MLP) classifiers, our approach achieves unprecedented accuracy in differentiating moderate NPDR to early proliferative diabetic retinopathy.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Method&lt;/h3&gt;&lt;div&gt;We developed a novel radiomic and MLA framework to extract features (vascular, image-based, and clinical) from leakage source regions in OCT-A images identified by corresponding FFA images. XGboost, Adaptive Boost, MLP classifier were created to evaluate their diagnostic accuracy for different DR stages. MLA performance was comprehensively evaluated via multiple metrics (accuracy, precision, recall, AUC, sensitivity, specificity) and visualized through confusion matrices (CMs) and receiver operating characteristic (ROC) curves to ensure robust clinical applicability.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Result&lt;/h3&gt;&lt;div&gt;A dataset of 99 patients and 179 images was included. For staging in DR, the highest accuracy (96.6 ± 1.4% [95% CI: 93.9 − 99.3%]) and AUC (98.9 ± 0.5%) were observed for the XGBoost classifier with all image-based features alone. The MLP performed better with vascular and clinical features. (Accuracy: 92.5 ± 3.2%92.5[95% CI: 86.2 − 98.8%], AUC: 95.2%) Entropy, Haralick, GLCM, eccentricity, vessel branch, vessel density, tortuosity (combining geometric analysis and wavelet transform), fractal dimension analysis (combining box counting and wavelet-based), and fast blood sugar emerged as particularly significant discriminative features across DR stages.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Our approach identifies distinctive vascular and textural biomarkers—including hybrid fractal dimension, vessel tortuosity, and Haralick features—that effectively differentiate DR stages while providing new pathophysiological insights into microvascular remodeling in leakage-prone areas. By bridging non-invasive OCT-A with leakage-specific assessment, this method offers a clinically viable tool for early detection, progression prediction, and personalized DR management. Although limited by macular-centric scans and exclusion of very early/advanced stages, our findings establish a foundation for future multi-center studies with wider fields of view. This work represents a significant advance toward AI-enhanced ophthalmology, paving the way for actionable diagnostic paradigms in diabeti","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"59 ","pages":"Article 105522"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147990503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fiber balloon catheter for uniform light delivery in intraductal photodynamic therapy of bile duct tumors","authors":"Yiwen Lu ,&nbsp;Gaoqi Liu ,&nbsp;Meng Zhao ,&nbsp;Le Jiang ,&nbsp;Rongqian Wu ,&nbsp;Yi Lyu ,&nbsp;Xiaogang Zhang ,&nbsp;Lihui Pang ,&nbsp;Rongfeng Wang","doi":"10.1016/j.pdpdt.2026.105519","DOIUrl":"10.1016/j.pdpdt.2026.105519","url":null,"abstract":"<div><h3>Background</h3><div>Intraductal photodynamic therapy (PDT) is a promising minimally invasive treatment for bile duct tumors, but clinical efficacy is limited by uneven intraductal light distribution and light dose attenuation induced by intraluminal blood and bile.</div></div><div><h3>Objective</h3><div>To develop an optical transmission device for intraductal PDT of bile duct tumors and optimize the light irradiation strategy.</div></div><div><h3>Methods</h3><div>The power density distribution was analyzed by COMSOL simulation, and laser attenuation by blood and bile was quantified using an integrating sphere power meter. A fiber–balloon catheter was constructed and evaluated in two pigs that received hematoporphyrin derivative (2 mg/kg) 48 h preoperatively. Under cholangiographic guidance, the device was inserted via enterotomy, and laser irradiation was delivered at 100 mW/cm² for 1200 s. Histopathology was assessed at 3 days post-PDT.</div></div><div><h3>Results</h3><div>Blood and bile caused 32.5 % to 45.8 % laser power attenuation. In a 1-cm-diameter duct, eccentric fiber positioning produced 2- to 3-fold wall power density variations. The balloon catheter maintained stable central fiber positioning, expelled intraluminal fluids, and caused no adverse events. Histopathology revealed circumferential, uniform bile duct epithelial necrosis at 3 days post-PDT.</div></div><div><h3>Conclusions</h3><div>The cylindrical fiber balloon catheter is safe and feasible, and it can effectively improve the uniformity of light irradiation during intraductal PDT for bile duct tumors.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"59 ","pages":"Article 105519"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148007704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of macular microcirculation in prediabetic patients using OCT angiography","authors":"Yigit Cay ,&nbsp;Sedat Can Guney ,&nbsp;Cumali Degirmenci ,&nbsp;Ilgın Yıldırım Simsir ,&nbsp;Filiz Afrashi ,&nbsp;Lütfiye Füsun Saygılı","doi":"10.1016/j.pdpdt.2026.105533","DOIUrl":"10.1016/j.pdpdt.2026.105533","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate whether subtle vascular pathologies undetectable by fundus examination can be identified in the prediabetic stage using OCTA.</div></div><div><h3>Setting</h3><div>Ege University Hospital, Izmir</div></div><div><h3>Design</h3><div>Retrospective Cohort</div></div><div><h3>Methods</h3><div>Best corrected visual acuity, intraocular pressure, detailed anterior and posterior segment examinations, OCT angiography (OCTA) were performed on patients diagnosed with prediabetes in the internal medicine department. OCTA was performed using an OptoVue AngioVue XR Avanti SD-OCT (Fremont, USA). Total, foveal, para-perifoveal superficial and deep vasculature; foveal avascular zone (FAZ), outer retina and choriocapillaris were evaluated. Patients with known ocular disease, severe refractive error, best-corrected visual acuity (BCVA) &lt; 0.8 (Snellen), poor OCTA image quality (signal strength ≤ 50), history of ocular surgery or intravitreal injection and systemic diseases other than controlled hypertension or dyslipidemia excluded. Patients without prediabetes (also without any systemic diseases) were included in the study as the control group</div></div><div><h3>Results</h3><div>The mean age was 52.93 ± 11.41 years in the prediabetic group and 50.14 ± 10.71 years in controls, with no significant difference (p = 0.094). Total deep and superficial, foveal deep, perifoveal superficial vascular densities were significantly lower in the prediabetic group (p &lt; 0.05). Prediabetic patients with hypertension showed no change of vascular densities compared with those without hypertension. Those with high total cholesterol had lower choriocapillaris flow (p = 0.01). HbA1c was not correlated with any OCTA parameter</div></div><div><h3>Conclusion</h3><div>Patients with prediabetes exhibit subtle but significant reductions in retinal vascular density, particularly within the superficial capillary plexuses when compared with normoglycemic controls. Ophthalmologists and endocrinologists should consider OCTA findings as part of a broader metabolic assessment, particularly for individuals with risk factors such as obesity, dyslipidemia, or family history of diabetes.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"59 ","pages":"Article 105533"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148102378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UV spectroscopy associated with machine learning as a complementary tool for the diagnosis of Ehrlichia canis in dogs","authors":"Letícia Borges Seidenfuss Antunes ,&nbsp;Thiago França ,&nbsp;Ivanise Paula Sobota ,&nbsp;Cícero Cena ,&nbsp;Carlos Alberto do Nascimento Ramos","doi":"10.1016/j.pdpdt.2026.105530","DOIUrl":"10.1016/j.pdpdt.2026.105530","url":null,"abstract":"<div><div>Canine ehrlichiosis, caused by <em>Ehrlichia canis</em>, is a tick-borne disease with a global distribution that significantly affects the clinical and epidemiological landscape for dogs. Although laboratory diagnosis is essential, current diagnostic methods exhibit limitations in sensitivity, specificity, and cost-effectiveness. This study evaluated the efficacy of ultraviolet (UV) spectroscopy combined with machine learning techniques to differentiate serological samples that are positive and negative for <em>E. canis</em>. A total of 46 canine serum samples, classified via Enzyme-Linked Immunosorbent Assay/Dot-Enzyme-Linked Immunosorbent Assay, were analyzed. Spectra (200–300 nm) underwent dimensionality reduction through principal component analysis, and classification using supervised algorithms, specifically support vector machine. In the binary classification of <em>E. canis</em> positive and negative sera, a linear SVM model (5 PCs) achieved 89.3% accuracy via Leave-One-Out Cross-Validation (LOOCV), yielding 85.7% sensitivity and 92.9% specificity. In the independent test set, the model reached 100% accuracy, sensitivity, and specificity, demonstrating high robustness and potential for diagnostic screening. The findings indicate that UV spectroscopy, in conjunction with machine learning, may serve as an effective complementary tool for diagnosing <em>E. canis</em>.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"59 ","pages":"Article 105530"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148102437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of photodynamic therapy on accumulation of Streptococcus mutans on the surface of orthodontic composite used in fixed retainers: An in vitro study","authors":"Zeynab Moradi Cherati ,&nbsp;Hannaneh Ghadirian ,&nbsp;Sogol Saberi ,&nbsp;Shima Afrasiabi ,&nbsp;Mohammad Ali Keshvad","doi":"10.1016/j.pdpdt.2026.105509","DOIUrl":"10.1016/j.pdpdt.2026.105509","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to assess the effect of antimicrobial photodynamic therapy (PDT) on accumulation of <em>Streptococcus mutans</em> (<em>S. mutans</em>) on the surface of orthodontic composite used in fixed retainers.</div></div><div><h3>Materials and methods</h3><div>In this in vitro study, 60 Ortho Connect Flow composite discs were evaluated in two groups (<em>n</em> = 30) of fresh and aged (by thermocycling and toothbrushing). Composite discs in each group were inoculated with <em>S. mutans</em>, and evaluated in 5 subgroups (<em>n</em> = 6) of control, diode laser alone (660 nm, 200 mW, 400 mW/cm², 24 J/cm², continuous-wave mode, for 60 s), methylene blue (MB = 100 µg/mL), PDT with diode laser (with the aforementioned parameters) and MB, and 0.2 % chlorhexidine (CHX). After the treatments<em>, S. mutans</em> colonies were counted, and data were analyzed by three-way and two-way ANOVA (alpha = 0.05).</div></div><div><h3>Results</h3><div>The CHX group showed the lowest colony count. The effects of 660 nm diode laser, MB, and their interaction (PDT) on colony count were all significant (<em>P</em> &lt; 0.05). The PDT group also showed a significantly lower colony count than other groups (<em>P</em> &lt; 0.05). The difference in colony count between the fresh and aged discs was not significant (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>The results of this in vitro study showed that PDT with 660 nm diode laser (with the aforementioned parameters) and MB significantly prevented the accumulation of <em>S. mutans</em> on the surface of orthodontic composite, and may be suitable as an adjunct for biofilm control.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"59 ","pages":"Article 105509"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement of anterior segment parameters measured by Scheimpflug-based Scansys and Pentacam HR: A prospective, cross-sectional comparative study","authors":"Yanfen Liao ,&nbsp;Pengfei Li ,&nbsp;Lei Si ,&nbsp;Zhengwei Shen ,&nbsp;Suli Yang ,&nbsp;Zhongling Yuan ,&nbsp;Bin Zhang ,&nbsp;Liang Xie","doi":"10.1016/j.pdpdt.2026.105521","DOIUrl":"10.1016/j.pdpdt.2026.105521","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to systematically evaluate the repeatability, differences, and agreement between Scansys and Pentacam HR for measuring anterior segment parameters.</div></div><div><h3>Methods</h3><div>This prospective consistency evaluation study evaluated 222 patients' right eyes at our hospital from October to December 2025, analyzing anterior segment parameters with Scansys and Pentacam HR through three scans per eye. Measurement repeatability for both devices was assessed. Differences between devices were analyzed, and agreement was evaluated.</div></div><div><h3>Results</h3><div>Both Scansys and Pentacam HR demonstrated excellent measurement repeatability (ICC &gt;0.9). No significant differences were observed in corneal curvature between the two devices. Although significant differences in corneal thickness, horizontal white-to-white (HWTW), anterior chamber depth (ACD), anterior chamber angle, and corneal volume were noted, these were clinically insignificant. Meanwhile, Q value, pupil diameter (PD), and anterior chamber volume (ACV) were significantly different. Agreement analysis showed that key parameters (corneal curvature, corneal astigmatism, corneal thickness, and corneal volume) demonstrated excellent agreement between devices (ICC &gt;0.9; narrow 95% limits of agreement). However, agreement was poor for corneal asphericity, ACV, and PD (ICC &lt;0.75). HWTW and ACD showed good agreement, but their 95% limits of agreement were wide.</div></div><div><h3>Conclusion</h3><div>Scansys has good stability, and its measurements of corneal curvature and thickness align well with Pentacam HR, allowing safe interchange. However, parameters like corneal asphericity, ACV, and PD show poor consistency and should not be used interchangeably. Caution is warranted when using HWTW and ACD interchangeably in high-precision applications. Taken together, this study supports rational device selection in clinical practice.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"59 ","pages":"Article 105521"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148007758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}