Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Efficacy of 5-aminolevulinic acid photodynamic therapy versus observation for cervical low-grade squamous intraepithelial lesion with type 3 transformation zone","authors":"Ruizhe Chen ,&nbsp;Junfen Xu ,&nbsp;Chun Ye ,&nbsp;Lingjia Lu ,&nbsp;Ying Li ,&nbsp;Lingfang Wang ,&nbsp;Xiaodong Cheng ,&nbsp;Yunfeng Fu","doi":"10.1016/j.pdpdt.2025.104679","DOIUrl":"10.1016/j.pdpdt.2025.104679","url":null,"abstract":"<div><h3>Background</h3><div>The treatment for patients with cervical low-grade squamous intraepithelial lesion (LSIL) and type 3 transformation zone (TZ) had limitations. The aim of this study was to compare the efficacy of new approach 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and observation in those patients.</div></div><div><h3>Methods</h3><div>This study retrospectively analyzed data from 236 patients (aged 25–45 years) with cervical LSIL and type 3 TZ. Participants were divided into ALA-PDT and observation groups, and were followed up for 1-year post-diagnosis. Outcomes were compared and factors influencing LSIL regression and human papillomavirus (HPV) clearance were analyzed.</div></div><div><h3>Results</h3><div>The LSIL regression rate was 89.8 % in the ALA-PDT group, significantly higher than 68.4 % in the observation group (<em>P</em> &lt; 0.05). The ALA-PDT group demonstrated a significantly higher HPV clearance rate of 69.5 % compared to 39.0 % in the observation group (<em>P</em> &lt; 0.05). No significant correlation was found between baseline clinical characteristics and LSIL regression or HPV clearance in either group.</div></div><div><h3>Conclusion</h3><div>ALA-PDT is effective in promoting LSIL regression and HPV clearance. ALA-PDT may be considered as a viable treatment option for women with type 3 TZ, persistent LSIL and high-risk HPV infection, The efficacy of ALA-PDT is not affected by clinical characteristics, suggesting its benefit for patients with various clinical risk factors.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104679"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting HSV-1 glycoprotein D through riboflavin-mediated photodynamic therapy: Insights from bioinformatics analysis and in vitro evaluation","authors":"Maryam Pourhajibagher ,&nbsp;Sayed Mahdi Marashi ,&nbsp;Abbas Bahador","doi":"10.1016/j.pdpdt.2025.104683","DOIUrl":"10.1016/j.pdpdt.2025.104683","url":null,"abstract":"<div><h3>Introduction</h3><div>The herpes simplex virus type 1 (HSV-1) causes painful viral lesions in the mucosal and cutaneous areas of the oral cavity as well as the head and neck. photodynamic therapy (PDT) effectively inactivates HSV-1 by targeting multiple structures and molecules without the risk of developing resistant strains. The most significant factor influencing the antiviral efficacy of PDT is the type of photosensitizer used. Therefore, finding more effective photosensitizers is essential. This study utilizes biological databases and bioinformatics tools to investigate computational simulations, molecular docking, and the <em>in vitro</em> antiviral effects of PDT using riboflavin in combination with a light-emitting diode (LED) against HSV-1.</div></div><div><h3>Materials and Methods</h3><div>The three-dimensional structures of glycoprotein D, the viral attachment protein of HSV-1, were predicted and validated using <em>in silico</em> methods. The physicochemical properties of this protein and the quality of the model were assessed. Molecular docking was performed, followed by the determination of the ADME/Tox profile, pharmacokinetic properties, and drug-likeness characteristics of riboflavin. Changes in viral load following PDT using riboflavin against HSV-1 were assessed by a virus titration assay and quantitative polymerase chain reaction (qPCR).</div></div><div><h3>Results</h3><div>It was determined that riboflavin does not violate Lipinski’s Rule of Five as a widely used guideline that predicts the likelihood of a compound being orally active in humans. Riboflavin was classified as toxicity class 6 (very low toxicity) and was found to be non-toxic to the liver, non-immunotoxic, and non-cytotoxic. Molecular docking studies using the three-dimensional model of glycoprotein D with the riboflavin ligand showed good binding affinity. Additionally, the <em>in vitro</em> results of the study showed that LED-activated riboflavin effectively inhibits HSV-1 replication during PDT, resulting in a significant reduction in viral load (P&lt;0.05).</div></div><div><h3>Conclusion</h3><div>The study’s findings indicate that riboflavin, possessing drug-like characteristics, can successfully engage with glycoprotein D, demonstrating a high binding affinity. Additionally, PDT using riboflavin has been shown to effectively suppress HSV-1 replication. Consequently, riboflavin-mediated PDT, by lowering viral load, emerges as a promising supplementary treatment for HSV-1.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104683"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive-optics scanning laser ophthalmoscopy study of non-arteritic anterior ischemic optic neuropathy","authors":"Wenting Gu ,&nbsp;Zizhong Hu ,&nbsp;Weijie Chen ,&nbsp;Qinghuai Liu ,&nbsp;Yonghui Gu","doi":"10.1016/j.pdpdt.2025.104678","DOIUrl":"10.1016/j.pdpdt.2025.104678","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the changes in cone photoreceptors in patients with non-arteritic anterior ischemic optic neuropathy (NAION).</div></div><div><h3>Methods</h3><div>Adaptive-optics scanning laser ophthalmoscopy (AO-SLO) was performed in patients with NAION and healthy participants. Acute NAION was defined as a disease duration of &lt;2 months, whereas chronic NAION was defined as a duration of &gt;2 months. We analyzed four quadrants (superior, inferior, nasal, and temporal with respect to the central fovea of the macula) of the cone layer images at 2.4° × 2.4° collected at 3° eccentricity. Patients with NAION were further examined by using optical coherence tomography (OCT).</div></div><div><h3>Results</h3><div>Significant differences were observed in peripapillary retinal nerve fiber layer and ganglion cell layer thicknesses between the normal and affected eyes (<em>P</em> &lt; 0.05). The AO-SLO data of patients with monocular NAION showed no statistical differences in the density, regularity, and dispersion of cone cells in the superior, inferior, nasal, and temporal quadrants (<em>P</em> &gt; 0.05). No significant differences were noted in the density among the healthy, acute NAION, and chronic NAION groups (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>AO-SLO showed cone integrity in patients with NAION. From a microscopic perspective, NAION might not affect cone photoreceptors.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104678"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on “Photodiagnosis with deep learning: A GAN and autoencoder-based approach for diabetic retinopathy detection” by Gencer et al., 2025","authors":"Ahmadreza Siyasari ,&nbsp;Motahareh Sabaghi Qalanou ,&nbsp;Sadegh Dehghanmehr","doi":"10.1016/j.pdpdt.2025.104666","DOIUrl":"10.1016/j.pdpdt.2025.104666","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104666"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of repeated low-level red-light therapy combined with defocus incorporated multiple segments spectacles for controlling childhood myopia","authors":"Chang-Kang Luo ,&nbsp;Chun-Yan Lai ,&nbsp;Jia-Hao Tan ,&nbsp;Wei Zhao ,&nbsp;Qing-Qing Tan","doi":"10.1016/j.pdpdt.2025.104681","DOIUrl":"10.1016/j.pdpdt.2025.104681","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the differences in the efficacy of repeated low-level red-light (RLRL) therapy combined with either single-vision spectacles (SVS) or defocus incorporated multiple segments (DIMS) spectacles in slowing myopia progression in children.</div></div><div><h3>Methods</h3><div>A total of 129 myopic children aged 6–14 years were recruited between July 2023 and February 2024. Participants had at least one eye with spherical equivalent refraction (SER) &lt;-0.50D and astigmatism ≤ 3.00D after cycloplegia. They were divided into four groups: SVS, DIMS, RLRL combined with SVS (RCS), and RLRL combined with DIMS (RCD). The RCS and RCD groups wore spectacles and received daily RLRL therapy sessions. The primary outcome was the change in axial length (AL) at 12 months.</div></div><div><h3>Results</h3><div>After 12 months, the mean changes of AL were: 0.26 mm (95 % CI, 0.17 to 0.35 mm) for SVS, 0.16 mm (95 % CI, 0.11 to 0.21 mm) for DIMS, -0.21 mm (95 % CI, -0.45 to 0.02 mm) for RCS, and -0.14 mm (95 % CI, -0.27 to -0.01 mm) for RCD. Significant differences were observed between groups (<em>F</em> = 15.18, <em>P</em> &lt; 0.001). Post-hoc tests showed that the RCS and RCD groups exhibited significantly greater shortening compared to the SVS and DIMS groups (all <em>P</em> &lt; 0.001). However, no significant difference was observed between the RCS and RCD groups (<em>P</em> &gt; 0.05). No severe adverse events or safety concerns related to RLRL therapy were observed throughout the study.</div></div><div><h3>Conclusion</h3><div>RLRL therapy is a potentially effective and practical approach for myopia control, demonstrating comparable efficacy when combined with either SVS or DIMS spectacles.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104681"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of atrophic macular hole in pathologic myopia: A multicenter study","authors":"Hai-Long He ,&nbsp;Guang-Qi An ,&nbsp;Yue Qi ,&nbsp;Xiao-Bing Yu ,&nbsp;Ming-Wei Zhao ,&nbsp;Zong-Ming Song ,&nbsp;Xue Min Jin ,&nbsp;Li-Ping Du ,&nbsp;Zi-Bing Jin","doi":"10.1016/j.pdpdt.2025.104680","DOIUrl":"10.1016/j.pdpdt.2025.104680","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aims to describe and analyze the clinical characteristics of atrophic macular hole (AMH), a severe complication in patients with pathologic myopia (PM).</div></div><div><h3>Methods</h3><div>A multicenter, retrospective analysis was conducted involving 17 patients (17 eyes) diagnosed with AMH and 52 patients (52 eyes) diagnosed with simple macular hole (SMH) in PM from January 2023 to December 2023. Clinical data and multimodal images were collected. The age, gender, spherical equivalent (SE), axial length (AL), and best-corrected visual acuity (BCVA) of patients with AMH were described and their imaging characteristics analyzed.</div></div><div><h3>Results</h3><div>Of the 17 patients diagnosed with AMH, 15 (88.24 %) were female; the mean age was 64.59±12.61 years; the SE was -17.85±4.15 D; the AL was 30.40±1.67 mm; and the BCVA was 1.30 (1.00, 1.35) logMAR. Eleven eyes (64.71 %) exhibited myopic foveoschisis, seven eyes showed choroidal neovascularization (Fuchs spot), one eye had a concomitant epiretinal membrane, and no cases of retinal detachment involving the macula were observed. Axial length and neovascularization were significant correlates of BCVA in AMH patients (<em>P</em> &lt; 0.05). Compared with SMH in PM, patients with AMH were older (<em>t</em> = 2.247, <em>P</em> = 0.028) and had worse BCVA (<em>Z</em> = 375, <em>P</em> = 0.037); no significant differences were found between the two groups in terms of gender, SE, and AL (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>We propose the term “atrophic macular hole” to describe a condition resembling a macular hole accompanied by atrophy of the RPE and choroid, caused by progressive degeneration of the outer retina or traction of the eyeball, which severely impairs central vision in patients.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104680"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term postoperative changes in nucleus drop cases during phacoemulsification surgery: a comparative analysis of the choroidal vascular index following pars plana vitrectomy","authors":"Ali Hakim Reyhan ,&nbsp;Funda Yüksekyayla ,&nbsp;İrfan Uzun ,&nbsp;Çağrı Mutaf ,&nbsp;Mübeccel Bulut ,&nbsp;Ali Şimşek ,&nbsp;Mehmet Eryavuz","doi":"10.1016/j.pdpdt.2025.104676","DOIUrl":"10.1016/j.pdpdt.2025.104676","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluated the clinical outcomes of cases of nucleus drop developing during phacoemulsification surgery. It particularly focused on analyzing the effects of pars plana vitrectomy (PPV) on postoperative visual and anatomical parameters, including choroidal thickness and the choroidal vascular index (CVI).</div></div><div><h3>Methods</h3><div>Patients who experienced nucleus drop during phacoemulsification and subsequently underwent PPV were reviewed retrospectively. Data for these cases were compared with a group of patients who underwent uncomplicated phacoemulsification and with a healthy control group. Key parameters assessed included surgical outcomes and changes in choroidal metrics, including quantitative assessments of choroidal thickness in various regions and the CVI, measured using enhanced depth imaging optical coherence tomography.</div></div><div><h3>Results</h3><div>Mean visual acuity in the PPV eyes was 0.44±0.11, significantly lower than the 0.71±0.13 in the phacoemulsification group and 0.80±0.08 in the controls (p &lt; 0.001). Nasal choroidal thickness at 1000 µm was markedly lower in the PPV eyes (282.08±53.67 µm) compared with both the phacoemulsification (341.94±54.88 µm) and control (379.19±67.65 µm; p &lt; 0.001) groups, with similar significant decreases being observed across other choroidal thickness parameters. However, no significant intergroup differences were observed in terms of CVI or stromal area/luminal area (LA/SA) ratio values (p &gt; 0.05).</div></div><div><h3>Conclusions</h3><div>The study findings demonstrated that decreases observed in choroidal thickness, total choroidal area, luminal area, and stromal area measurements indicate that this procedure affects the anatomical structure. However, the similarities in CVI and LA/SA ratio values suggest that the relative balance within the microvascular structure is maintained.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104676"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of choroidal vascular changes in juveniles with different degrees of myopia: The application of swept-source optical coherence tomography angiography","authors":"Linbo He ,&nbsp;Qing Wang ,&nbsp;Ziyang Li ,&nbsp;Libing Song ,&nbsp;Bo Liu ,&nbsp;Yuli Yang","doi":"10.1016/j.pdpdt.2025.104674","DOIUrl":"10.1016/j.pdpdt.2025.104674","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the vascular characteristic changes in the macular retina and choriocapillaris, as well as the choroidal vascularization of eyes with different degrees of myopia in juveniles using Swept-source Optical Coherence Tomography (SS-OCT), aiming to understand the pathophysiological characteristics of myopic eyes further.</div></div><div><h3>Methods</h3><div>We conducted a retrospective case-control study involving 103 patients (198 eyes) aged 6–17 years who had undergone SS-OCT examination. Based on equivalent spherical power, they were divided into four groups: emmetropia group, low myopia group, moderate myopia group, and high myopia group. The density of superficial capillary plexuses (SCP), choriocapillaris (CC), choroid vessel (CV)layers, and subfoveal choroidal thickness (SFCT) in the macular area were measured using SS-OCT. Multivariate regression analysis was employed to determine the ocular and demographic factors associated with retinal and choroidal blood flow indicators.</div></div><div><h3>Results</h3><div>In the temporal parafoveal area, the superficial capillary plexus (SCP) density was significantly lower in the moderate myopia group compared to the low myopia group (47.27 ± 2.21 vs. 48.51 ± 1.8, <em>p</em> = 0.002). Conversely, subfoveal choroidal vessel (CV) density was substantially higher in highly myopic eyes than in emmetropic eyes (56.98± 3.65 vs. 53.70 ± 4.31, <em>p</em> = 0.023). The multiple linear regression analysis showed that in the area under the fovea, thinner choroidal thickness is associated with higher choroidal vessel density. Specifically, as choroidal thickness decreases, the density of choroidal vessels increases (<em>p</em> = 0.024).</div></div><div><h3>Conclusions</h3><div>For juveniles, with the progression of myopia, the density of retinal superficial blood vessels and choroidal capillaries remains at a relatively stable level, while the choroidal vessel density under the fovea gradually increases. The main cause of changes in choroidal vessel density is the thickness of choroid under the fovea.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104674"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic chamber combined with photodynamic therapy inhibits bacterial growth on dental devices","authors":"Jeter Bochnia Ribeiro ,&nbsp;Augusto Alberto Foggiato ,&nbsp;Douglas Silva Fernandes ,&nbsp;João Victor Frazão Câmara ,&nbsp;Amanda de Oliveira Pinto Ribeiro ,&nbsp;Fabiana Mantovani Gomes França","doi":"10.1016/j.pdpdt.2025.104669","DOIUrl":"10.1016/j.pdpdt.2025.104669","url":null,"abstract":"<div><h3>Background</h3><div>Photodynamic therapy is a two-stage treatment that combines light energy with a photosensitizer, and enhances the treatment against bacterial infections. In this context, the present study evaluated a newly patented device, called an ultrasonic photodynamic inactivation device (UPID), which performs microbial inactivation using photodynamic therapy for both prosthetic braces (PBs) and prototyped surgical guides (PSGs).</div></div><div><h3>Methods</h3><div>Photodynamic inactivation was analyzed by contaminating the instruments with bacterial suspensions (3 × 10⁸ CFU/mL) of 100 µM/L methylene blue solution for 20 min, followed by irradiation (0.30 J/cm²) with red light-emitting diode (660 nm) for 20 min, on three types of microorganisms: <em>Candida albicans</em> ATCC 10,231, <em>Staphylococcus aureus</em> ATCC 25,923 and <em>Escherichia coli</em> ATCC 25,922. The PSGs included a group with irradiation for 30 min (0.45 J/cm²), and a control group with 0.2 % peracetic acid, evaluated at both 20-minute time points. Microbial inhibition was assessed by counting the number of colony-forming units (CFU), and by the data evaluated using the Shapiro-Wilk, Mann-Whitney-U, and Kruskal-Wallis tests, at a 5 % significance level.</div></div><div><h3>Results</h3><div>All experimental treatments showed significant reduction in log CFU/mL. The UPID promoted a significant microbial reduction (<em>p</em> &lt; 0.001), compared with the positive control. In addition, peracetic acid was more effective than PDT for the PSG (<em>p</em> &lt; 0.001). However, after 20 min, both treatments protected the surface material against bacterial growth.</div></div><div><h3>Conclusion</h3><div>The device proved effective for microbial inhibition of PB and PSG, thus proposing a new technique for the non-toxic disinfection of biomedical devices.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104669"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A meta-analysis of surgical margin status and prognosis after precise resection of liver cancer using fluorescence imaging-guided surgery","authors":"Fang Xie ,&nbsp;Qian Zhang ,&nbsp;Yuming Jia ,&nbsp;Kaijian Lei ,&nbsp;Hongru Yu ,&nbsp;Wei Zhang ,&nbsp;Li Li ,&nbsp;Daohong Kan","doi":"10.1016/j.pdpdt.2025.104663","DOIUrl":"10.1016/j.pdpdt.2025.104663","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study is to evaluate the value of intraoperative fluorescence imaging in assisting tumor localization and margin delineation during liver resection surgery, with the goal of improving the negative surgical margin rate and overall margin status.</div></div><div><h3>Methods</h3><div>A systematic search was conducted in the PubMed, Web of Science, Embase, and Cochrane Library databases for studies on the use of fluorescence imaging to aid in tumor localization and margin detection in liver cancer published between their inception and March 2025. After quality assessment of the included studies, a meta-analysis was performed using the STATA/SE 12.0 statistical software.</div></div><div><h3>Results</h3><div>A total of 10 studies comprising 1097 patients were included in this meta-analysis. Compared to conventional liver resection, fluorescence-guided hepatectomy significantly increased the R0 resection rate [Odds ratio (OR) = 2.51, 95 % confidence intervals (CI): 1.65, 3.81, <em>P</em> = 0.000], with similar results observed in subgroup analyses. In addition, the fluorescence-guided hepatectomy group showed significantly less intraoperative blood loss [Weighted mean differences (WMD) = -100.53, 95 % CI:171.38, -29.68, <em>P</em> = 0.005]. However, no statistically significant differences were observed between the two groups in terms of margin distance, operative time, intraoperative transfusion, hospital stay, or overall complication rate.</div></div><div><h3>Conclusion</h3><div>Fluorescence-guided hepatectomy can effectively increase the R0 resection rate and may contribute to reducing postoperative recurrence of liver cancer. However, further multicenter randomized controlled trials with larger sample sizes are needed to validate its impact on margin distance, operative time, intraoperative transfusion, hospital stay, and complication rates.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104663"},"PeriodicalIF":3.1,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}