Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Risk factors and management of hypotension and nausea during 5-aminolevulinic acid-assisted transurethral resection of bladder tumors under spinal anesthesia","authors":"Kento Hirao ,&nbsp;Takeshi Sano ,&nbsp;Hisanori Taniguchi ,&nbsp;Masaaki Yanishi ,&nbsp;Koei Muguruma ,&nbsp;Hidefumi Kinoshita","doi":"10.1016/j.pdpdt.2026.105365","DOIUrl":"10.1016/j.pdpdt.2026.105365","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate intraoperative adverse events in patients undergoing photodynamic diagnosis (PDD)-assisted transurethral resection of bladder tumor (TURBT) using oral 5-aminolevulinic acid (5-ALA) (ALA-PDD-TURBT) under spinal anesthesia.</div></div><div><h3>Methods</h3><div>This single-center retrospective study included 109 patients who underwent ALA-PDD-TURBT under spinal anesthesia between January 2019 and April 2023. Hypotension was defined as a systolic blood pressure ≤ 80 mmHg. We evaluated the incidence of any adverse events and investigated the risk factors for hypotension, nausea, and vomiting.</div></div><div><h3>Results</h3><div>Hypotension was observed in 64 patients (58.7 %), while nausea and vomiting were observed in 29 patients (26.6 %). No adverse events of Clavien-Dindo grade ≥ 3 were observed. No significant association was found between hypotension and various patient-related factors, including age, sex, smoking history, comorbidities, presence of hypertension, use of antihypertensive agents, continuation of antihypertensive medication on the day of surgery, and administration of α-blockers for benign prostatic hyperplasia on examination. Regarding nausea and vomiting, the use of phenylephrine was identified as a significant risk factor (odds ratio, 10.2; 95 % confidence interval, 1.92–53.90; <em>P</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>Our findings suggest that ALA-PDD-TURBT is a safe procedure with a low risk of severe complications. Although hypotension, nausea, and vomiting were relatively common, they were generally manageable with pharmacological interventions. No strong predictive risk factors for hypotension were identified; however, the use of phenylephrine was associated with an increased risk of nausea and vomiting.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105365"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spherical equivalent and visual acuity outcomes in the randomized, double-blind, placebo-controlled trial of bendazol eye drop atomization for slowing myopia progression in children","authors":"Yan Hei Yannis Chan ,&nbsp;Sunny Chi Lik Au","doi":"10.1016/j.pdpdt.2026.105366","DOIUrl":"10.1016/j.pdpdt.2026.105366","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105366"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of ALA-PDT and intracavitary triamcinolone acetonide lavage for perifolliculitis capitis abscedens et suffodiens: A case series","authors":"Yue Quan ,&nbsp;Zhaoyang Liu ,&nbsp;Danfeng Yuan ,&nbsp;Lisha Tan ,&nbsp;Boyu Zhao ,&nbsp;Xinyue Pang ,&nbsp;Zhongqi Jiang ,&nbsp;Huiping Wang ,&nbsp;Shuping Hou","doi":"10.1016/j.pdpdt.2026.105355","DOIUrl":"10.1016/j.pdpdt.2026.105355","url":null,"abstract":"<div><h3>Significance</h3><div>Perifolliculitis capitis abscedens et suffodiens (PCAS) is a chronic, refractory, and recurrent inflammatory disorder of the scalp that severely affects patients’ quality of life and appearance. Despite various available treatments, no optimal therapeutic strategy has been established. Compared to conventional therapies, 5-aminolevulinic acid photodynamic therapy (ALA-PDT) demonstrates favorable efficacy and tolerability. Pretreatment before photodynamic therapy plays a crucial role in optimizing therapeutic outcomes. This study evaluated the efficacy of ALA-PDT combined with intracavitary triamcinolone lavage in the management of PCAS.</div></div><div><h3>Approach</h3><div>Four patients with PCAS were treated using ALA-PDT following intracavitary triamcinolone lavage pretreatment. Therapeutic efficacy was assessed by comparing symptom improvement before and after treatment.</div></div><div><h3>Results</h3><div>All four patients achieved significant clinical improvement and exhibited good treatment tolerance, with no serious adverse reactions observed. During a minimum follow-up period of 6 months, no disease recurrence was detected in any of the patients.</div></div><div><h3>Conclusions</h3><div>ALA-PDT combined with intracavitary triamcinolone lavage pretreatment appears to be a safe and effective therapeutic option for PCAS. This combined approach may offer enhanced clinical outcomes compared with monotherapy, although treatment parameters should be individualized according to each patient’s condition.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105355"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of intermittent exotropia and surgical realignment on myopia progression in myopic children","authors":"Chao Li ,&nbsp;ZhiYin Lou ,&nbsp;WeiFen Gong,&nbsp;ShiBin Lin,&nbsp;WenLi Zhang,&nbsp;Fan Yang","doi":"10.1016/j.pdpdt.2026.105374","DOIUrl":"10.1016/j.pdpdt.2026.105374","url":null,"abstract":"<div><h3>Purpose</h3><div>To determine whether untreated intermittent exotropia (IXT) accelerates pediatric myopia and whether strabismus surgery modifies this risk.</div></div><div><h3>Methods</h3><div>This retrospective study enrolled 259 children aged 6–14 years with spherical equivalent refraction (SER) ≤ −0.75 D; 90 orthotropic controls, 86 untreated IXT, and 83 post-surgery IXT (PS-IXT) with successful alignment. Exclusion criteria included prior ocular surgery, trauma, or myopia-control interventions. After standardized cycloplegia, certified optometrists measured SER and axial length (AL) at baseline, 6 and 12 months.</div></div><div><h3>Results</h3><div>Baseline SER, AL, age and gender distribution did not differ among the three cohorts (all <em>P</em> &gt; 0.05). At the 12-month endpoint, the IXT group exhibited a significantly greater myopic shift (−0.91 ± 0.36 D vs -0.50(-0.75,-0.37) D; <em>P</em> &lt; 0.001) and axial elongation (0.41 ± 0.17 mm vs 0.30(0.20,0.36) mm; <em>P</em> &lt; 0.001) relative to orthotropic controls. Similarly, when compared with the surgically aligned (PS-IXT) group, the IXT cohort displayed excess myopic progression (−0.91 ± 0.36 D vs -0.38(-0.63,-0.13) D; <em>P</em> &lt; 0.001) and axial elongation (0.41 ± 0.17 mm vs 0.25(0.13,0.37) mm; <em>P</em> &lt; 0.001). In contrast, the PS-IXT and control groups were comparable for both refractive change (-0.50(-0.75,-0.37) D vs -0.38(-0.63,-0.13) D; <em>P</em> = 0.204) and axial elongation (0.30(0.20,0.36) mm vs 0.25(0.13,0.37) mm; <em>P</em> = 0.998).</div></div><div><h3>Conclusion</h3><div>Untreated IXT constitutes an independent, modifiable driver of accelerated myopia in children; timely surgical realignment normalizes the subsequent refractive and axial trajectory and should be incorporated into comprehensive myopia-prevention strategies.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105374"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel OCT angiography parameters for analyzing microvascular changes in proliferative diabetic retinopathy after intravitreal conbercept loading injections","authors":"Zikang Xie,&nbsp;Rongtian Chen,&nbsp;Lijun Zhou,&nbsp;Chuangxin Huang,&nbsp;Chenjin Jin","doi":"10.1016/j.pdpdt.2026.105357","DOIUrl":"10.1016/j.pdpdt.2026.105357","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the effects of intravitreal Conbercept (IVC) loading injections on proliferative diabetic retinopathy (PDR) retinal microvasculature using novel optical coherence tomography angiography (OCTA) parameters.</div></div><div><h3>Methods</h3><div>This retrospective study included 25 eyes of 25 treatment-naïve PDR patients who received monthly IVC for 3 consecutive months. At baseline and after IVC loading injections, OCTA novel parameters, including vessel skeleton density (VSD), vessel diameter index (VDI), fractal dimension (FD), branch vessel tortuosity (BVT) and percentage area of nonperfusion (PAN), were measured in the superficial capillary plexus (SCP) and deep capillary plexuses (DCP). Best-corrected visual acuity (BCVA), central macular thickness (CMT), and traditional OCTA parameters such as vessel density (VD) and foveal avascular zone (FAZ) metrics were also recorded. Patients were grouped by baseline hemoglobin A1c (HbA1c) (&lt;8 % vs. ≥8 %) for subgroup analysis.</div></div><div><h3>Results</h3><div>After IVC loading injections, BCVA improved (P = 0.036), and CMT decreased (P &lt; 0.001). SCP-FD, DCP-VSD, and DCP-FD increased (P = 0.023, 0.031,0.036, respectively). Multivariate analysis revealed that baseline SCP-PAN was positively correlated with CMT reduction (β = 1.821, P = 0.016). In HbA1c &lt;8 % group, SCP-VDI, DCP-VSD, and DCP-FD increased (P = 0.022, 0.033, 0.033, respectively) after loading injections.</div></div><div><h3>Conclusions</h3><div>Novel OCTA parameters revealed that IVC loading injections can improve retinal microvasculature in PDR patients. However, using these novel parameters for follow-up and treatment assessment remains challenging under varying image processing conditions.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105357"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sonodynamic therapy inhibition of invasive glioma cells from tumor spheroids","authors":"Akhil Chandekar ,&nbsp;Sophia Renee Laurel ,&nbsp;Keya Gupta,&nbsp;Tyler Lee,&nbsp;Nicole Wakida,&nbsp;Henry Hirschberg","doi":"10.1016/j.pdpdt.2026.105384","DOIUrl":"10.1016/j.pdpdt.2026.105384","url":null,"abstract":"<div><h3>Background</h3><div>Glioblastoma multiforme (GBM) is characterized by extensive tumor cell invasion into normal brain tissue leading to tumor recurrence despite present day treatment protocols. Photodynamic therapy (PDT) has been shown to inhibit glioma cell invasion, but the poor penetration of light in brain tissue has set limitations. Sonodynamic therapy (SDT), utilizing sensitizer activation by ultrasound (US), has been proposed as an alternative to PDT. The advantage of SDT is that US has much lower tissue attenuation compared to visible light, allowing treatment to tumor margins buried deep within the brain and non-invasively through the intact skull. This study evaluates the ability of SDT to inhibit glioma cell invasiveness in a 3D Matrigel matrix glioma cell assay.</div></div><div><h3>Methods</h3><div>Glioma cell spheroids were embedded between 2 layers of Matrigel solution. After gelation, the embedded spheroids are incubated in a medium containing sonosensitizer for 18 h and then exposed to varying intensities and durations of US. Measurements of cell invasion distance were taken 4 days after the spheroids were embedded.</div></div><div><h3>Results</h3><div>SDT significantly inhibited cell invasiveness compared to untreated spheroids and spheroids treated with only US. If administered pre-implantation, SDT also inhibited subsequent cell invasion into the deposited Matrigel matrix. The effects of SDT applied repetitively at lower intensities, had a greater inhibitory effect than single shot treatment.</div></div><div><h3>Conclusion</h3><div>From this experimental study using GBM tumor spheroids, the results demonstrated that SDT significantly inhibited cell invasiveness and cell adhesion and had greater inhibitive effects when administered in repetitive form.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105384"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Dermoscopy of Pigmented Oral Lesions; A Research Study” [Photodiagnosis and photodynamic therapy 52(2025)104524]","authors":"Maryam Amirchaghmaghi ,&nbsp;Atessa Pakfetrat ,&nbsp;Bita Kiafar ,&nbsp;Toktam Zamani","doi":"10.1016/j.pdpdt.2026.105347","DOIUrl":"10.1016/j.pdpdt.2026.105347","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105347"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of topical 5-aminolevulinic acid versus Hiporfin photodynamic therapy in HPV-positive cervical intraepithelial neoplasia grade II","authors":"Lina Geng ,&nbsp;Wenyu Mo ,&nbsp;Guanwen Gao ,&nbsp;Zhihong Liu ,&nbsp;Danfang Yuan ,&nbsp;Qianyu Huang ,&nbsp;Changzhong Li","doi":"10.1016/j.pdpdt.2025.105329","DOIUrl":"10.1016/j.pdpdt.2025.105329","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;Given the global trend of delayed childbearing, the feasibility of non-surgical treatments—such as photodynamic therapy and conservative management—for CIN II has become an area of increasing research interest. Photodynamic therapy can be administered either systemically or locally; however, there remains a lack of consensus regarding its optimal clinical application. Based on rigorous patient selection, comprehensive informed consent, and a structured follow-up protocol, this study aims to evaluate and compare the therapeutic efficacy of different photodynamic therapy modalities and conservative treatment in patients with CIN II, thereby providing evidence-based guidance for individualized clinical management.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A retrospective analysis was carried out on 111 patients with CIN2 at Peking University Shenzhen Hospital and Zhujiang Hospital of Southern Medical University from October 2019 to December 2024. According to the inclusion and exclusion criteria, 46 patients were treated with ALA-PDT,32 with HPF-PDT, and 33 were assigned to the follow-up observation group. In the first month post-PDT treatment, two groups were followed up. All three groups were followed up during the 3rd to 5th months and the 6th to 12th months. Key evaluation metrics included the effectiveness of cervical lesion treatment and the rate of HR-HPV infection clearance.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;At the first month follow-up, three patients in the HPF-PDT group exhibited allergic reactions. At the 3rd to 5th months follow-up, three patients in the HPF-PDT group were found to have cervical canal adhesions. The efficacy rates following ALA-PDT at 3rd-5th months and 6th-12th months were 93.0% (40/43) and 100% (27/27), compared to 90.3% (28/31) and 95.7% (22/23) after HPF-PDT.HPV clearance rates following ALA-PDT at 3rd-5th and 6th-12th months were 58.7% (27/46) and 77.8% (21/27) compared to 46.9%(15/32) and 62.5% (15/24) after HPF-PDT, with no significant difference between the two groups (&lt;em&gt;P&lt;/em&gt; = 0.675 at 3rd-5th months, &lt;em&gt;P&lt;/em&gt; = 0.274 at 6th-12th months; &lt;em&gt;P&lt;/em&gt; = 0.303 and &lt;em&gt;P&lt;/em&gt; = 0.705, respectively). Both rates were significantly higher than those of the observation group (39.4% (13/33) and 62.1% (18/29), &lt;em&gt;P&lt;/em&gt; &lt; 0.0001 and &lt;em&gt;P&lt;/em&gt; &lt; 0.0001; 6.1% (2/33) and 10.3% (3/29), &lt;em&gt;P&lt;/em&gt; &lt; 0.0001 and &lt;em&gt;P&lt;/em&gt; &lt; 0.0001). Due to follow-up discontinuation for some patients from June to December, a sensitivity analysis using March–May data yielded consistent results.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;While both ALA-PDT and HPF-PDT demonstrate comparable and high efficacy for CIN2, their risk-benefit profiles are distinct. HPF-PDT is associated with a clinically significant risk of cervical adhesions and potentially burdensome, prolonged systemic photosensitivity. Therefore, for patients without endocervical involvement, ALA-PDT presents a superior safety profile and ","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105329"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Using a new type of visible light-based emission fluorescence microscope to identify the benign and malignant nature of thyroid tissue during the surgical process: Analysis of diagnostic results” [Photodiagnosis and Photodynamic Therapy 57 (2026) 105324]","authors":"Yu Miao ,&nbsp;Liu Xiaowei ,&nbsp;Li Muyang ,&nbsp;Gao Jian ,&nbsp;Chen Lu","doi":"10.1016/j.pdpdt.2026.105410","DOIUrl":"10.1016/j.pdpdt.2026.105410","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105410"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced in vitro photodynamic therapy for triple-negative breast cancer by pheophorbide a-encapsulated chitosan-tripolyphosphate nanoparticles","authors":"Wen-Yao Yin ,&nbsp;Zih-You Lin ,&nbsp;Mei-Ying Wang ,&nbsp;Dhivyabharathi Balakrishnan ,&nbsp;Cheng-I Lee","doi":"10.1016/j.pdpdt.2025.105332","DOIUrl":"10.1016/j.pdpdt.2025.105332","url":null,"abstract":"<div><div>Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer. Current treatment strategies typically involve surgical resection and chemotherapy, both of which are often associated with significant adverse effects. As an alternative, photodynamic therapy (PDT) offers a minimally invasive approach to selectively target tumor cells. In this work, PDT was evaluated using pheophorbide a (Pa) as a photosensitizer. To enhance its therapeutic efficacy, Pa was encapsulated in ionically crosslinked chitosan/tripolyphosphate (TPP) nanoparticles. Furthermore, nanoparticles synthesized from chitosan subjected to various pre-treatments were compared in terms of their physicochemical properties. The optimized Pa-loaded chitosan/TPP nanoparticles (PaCNPs) exhibited enhanced singlet oxygen (¹O₂) generation upon photoactivation of Pa. Cellular uptake and intracellular distribution of Pa were extensively examined in MDA-MB-453 and MDA-MB-231 cell lines. Notably, nanoparticle encapsulation resulted in a fourfold reduction in IC₅₀ in MDA-MB-231 cells, whereas no significant change was observed in MDA-MB-453 cells. The distinct responses of these cell lines to PaCNPs-mediated PDT in are further discussed.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105332"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}