Photodiagnosis and Photodynamic Therapy最新文献

{"title":"A multi-task deep learning pipeline integrating vessel segmentation and radiomics for multiclass retinal disease classification","authors":"Feng Yan ,&nbsp;Yanxia Liu ,&nbsp;Qingsong Zhao ,&nbsp;Guangguo He","doi":"10.1016/j.pdpdt.2025.105209","DOIUrl":"10.1016/j.pdpdt.2025.105209","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to develop a robust, multi-task deep learning framework that integrates vessel segmentation and radiomic analysis for the automated classification of four retinal conditions— diabetic retinopathy (DR), hypertensive retinopathy (HR), papilledema, and normal fundus—using fundus images.</div></div><div><h3>Materials and Methods</h3><div>A total of 2165 patients from eight medical centers were enrolled. Fundus images underwent standardized preprocessing including histogram equalization, normalization, resizing, and augmentation. Whole vessel and artery-vein segmentations were conducted using five deep learning models: U-Net, Attention U-Net, DeepLabV3+, HRNet, and Swin-Unet. From the segmented vascular maps, 220 radiomic features were extracted using PyRadiomics and Mahotas toolkits. The arteriovenous ratio (AVR) was also computed from artery and vein masks. ICC analysis was used to assess reproducibility across centers, with features below ICC &lt; 0.75 excluded. Feature selection was performed using Least Absolute Shrinkage and Selection Operator (LASSO), Recursive Feature Elimination (RFE), and Mutual Information (MI). The combined AVR and radiomic features were input into four classifiers— Extreme Gradient Boosting (XGBoost), Categorical Boosting (CatBoost), Random Forest (RF), and Ensemble. Models were trained and validated on stratified splits and externally tested on an independent cohort of 769 patients. Evaluation metrics included accuracy, area under curve (AUC), recall, and receiver operating characteristics (ROC) analysis.</div></div><div><h3>Results</h3><div>Swin-Unet outperformed all models with external Dice Similarity Coefficient (DSC) of 92.4 % for whole vessel and 89.8 % for artery-vein segmentation. Classification using the LASSO-Ensemble combination achieved test accuracy of 93.7 %, external test accuracy of 92.3 %, and AUC of 95.2 %. AVR estimates were consistent with clinical expectations and contributed significantly to class discrimination.</div></div><div><h3>Conclusion</h3><div>This multi-task pipeline demonstrates the potential of combining transformer-based segmentation with radiomics for accurate, interpretable retinal disease classification, showing strong generalizability for future clinical applications.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105209"},"PeriodicalIF":2.6,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of photodynamic therapy and estrogen cream for menopause women with cervical low-grade squamous intraepithelial lesion with human papillomavirus infection","authors":"Wendi Yang ,&nbsp;Guoqing Jiang ,&nbsp;Yunduo Liu ,&nbsp;Lijing Zhang ,&nbsp;Yajun Li","doi":"10.1016/j.pdpdt.2025.104791","DOIUrl":"10.1016/j.pdpdt.2025.104791","url":null,"abstract":"<div><h3>Background</h3><div>In menopausal women, decreased estrogen levels lead to genital tract mucosal atrophy and reduced mucosal immune function. Low-grade squamous intraepithelial lesions (LSIL) associated with persistent or newly acquired high-risk HPV infection may progress silently to high-grade squamous intraepithelial lesions (HSIL) and eventually cervical cancer.</div></div><div><h3>Objective</h3><div><strong>:</strong> This study aimed to evaluate the efficacy and safety of photodynamic therapy combined with estrogen in the treatment of menopausal women with LSIL and high-risk HPV infection.</div></div><div><h3>Methods</h3><div>A retrospective controlled study was conducted to compare LSIL regression and HPV clearance among three treatment groups: photodynamic therapy plus estrogen, interferon gel plus estrogen, and estrogen alone. Therapeutic outcomes were assessed using ThinPrep cytology (TCT), HPV testing, and colposcopic pathology at 3, 6, and 12 months post-treatment.</div></div><div><h3>Results</h3><div>The rates of LSIL regression and HPV clearance in the photodynamic therapy plus estrogen group were significantly higher than those in both the interferon gel plus estrogen group and the estrogen-alone group at 3, 6, and 12 months (<em>p</em> &lt; 0.05). Furthermore, the interferon gel plus estrogen group showed improved outcomes compared to estrogen alone, with statistically significant differences (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Photodynamic therapy combined with estrogen cream is an effective and safe treatment approach for menopausal women with LSIL and high-risk HPV infection.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104791"},"PeriodicalIF":2.6,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the efficacy of photodynamic therapy in treating cervical lesions and HPV infections and its influencing factors","authors":"Xueliang Hu ,&nbsp;Xuewang Guo ,&nbsp;Jing Sha ,&nbsp;Yu Dou ,&nbsp;Hui Ma ,&nbsp;Honglin Li ,&nbsp;Yanying Xu","doi":"10.1016/j.pdpdt.2025.104786","DOIUrl":"10.1016/j.pdpdt.2025.104786","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy of photodynamic therapy (PDT) in patients with human papillomavirus (HPV) infection and cervical lesions, meanwhile factors influencing the efficacy of PDT were analyzed.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed on 110 patients with HPV infection and cervical lesions. All patients underwent HPV genotyping, ThinPrep Cytology Test (TCT), and pathological examination, the changes before and after PDT treatment for 6 months were analyzed. In evaluating the therapeutic effect, if HPV is completely eliminated or cervical lesions return to normal, it was counted in the negative conversion rate; If HPV is partially eliminated or cervical lesions are downgraded but not return to normal, it was counted in the effective rate. Meanwhile, patients were grouped according to HPV vaccination history, menopausal status, transformation zone type and previous HPV infection history, and the therapeutic effects of anti-HPV and cervical lesion were compared among different groups.</div></div><div><h3>Results</h3><div>After PDT, the negative conversion rate of HPV was 45.45 % with an effective rate of 64.54 %; the negative conversion rate of TCT was 63.51 % with an effective rate of 68.91 %; and the negative conversion rate of pathology was 72.22 % with an effective rate of 79.62 %. The HPV negative conversion rate (78.57 % vs. 35.36 %) and TCT negative conversion rate (83.33 % vs. 57.14 %) in the vaccinated population were significantly higher than those in the unvaccinated population (<em>p</em> &lt; 0.05). The non-menopausal population showed significantly higher TCT negative conversion rate (72.00 % vs. 45.83 %) and effective rate (78.00 % vs. 45.83 %), as well as pathological negative conversion rate (85.36 % vs. 30.76 %) and effective rate (87.80 % vs. 46.15 %) compared with the menopausal population (<em>p</em> &lt; 0.05). Patients with type Ⅰ and Ⅱ transformation zone (TZ) show significantly better outcomes than those with TZ3 in anti-HPV treatment and cervical lesion management (<em>p</em> &lt; 0.05). Patients without a history of HPV infection had significantly higher TCT negative conversion rate (73.33 % vs. 35.89 %) and effective rate (73.33 % vs. 46.15 %) than those with a previous infection history (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>PDT shows good therapeutic effects in both HPV infection and cervical lesions. In addition, better therapeutic effects are observed in populations with a history of HPV vaccination, non-menopausal populations, populations without previous HPV infection, and those with type Ⅰ or Ⅱ cervical transformation zones.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104786"},"PeriodicalIF":2.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of corneal biomechanical parameters and corneal thickness measured by Corvis ST and AS-OCT in progressive keratoconus treated by accelerated corneal cross-linking","authors":"Luanying Wei,&nbsp;Tiantian Qi,&nbsp;Lei Luo,&nbsp;Qiang Shi,&nbsp;Shengjian Mi,&nbsp;Cheng Pei","doi":"10.1016/j.pdpdt.2025.104783","DOIUrl":"10.1016/j.pdpdt.2025.104783","url":null,"abstract":"<div><h3>Purpose</h3><div>To explore the characteristics of corneal biomechanical parameters and corneal thickness in different corneal regions in progressive keratoconus treated by accelerated “epithelium off” cross-linking (A-CXL) surgery.</div></div><div><h3>Methods</h3><div>This is a retrospective study and is self-controlled before and after surgery. A total of 39 eyes of 25 patients with progressive keratoconus were recruited and treated by A-CXL. The corneal biomechanical parameters and corneal thickness were recorded at baseline, 1-month, 3-month, and 6-month after surgery. Besides, analysis of correlations was applied to explore the association between these two features.</div></div><div><h3>Results</h3><div>Most of the biomechanical parameters, corneal thickness of different areas, as well as visual acuity, curvature and higher-order aberrations (HOAs), showed significant changes at 1 month and 3 months after surgery. Then gradually became stable and close to baseline values at 6 months postoperative. The epithelium became thicker earlier (after 1 month). The central and inferior areas of corneal stroma and the whole cornea were significantly thinnest at 3 months, other areas were thinnest at 1 month. Only several biomechanical parameters showed positive or negative correlations with corneal thickness, including the changes of them from baseline to different time after treatment.</div></div><div><h3>Conclusion</h3><div>The accelerated cross-linking not only has a significant effect, especially on the corneal central, inferotemporal, and inferonasal regions, which can prevent the progression of keratoconus. But also, can maintain the integrity of the epithelium, achieve corneal biomechanical recovery and improve visual acuity, curvature and HOAs in the short term at the same time.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104783"},"PeriodicalIF":2.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The photodynamic antimicrobial chemotherapy activities of azaBODIPY dyes and their gold nanoparticle conjugates","authors":"Temlandvo M. Magwaza,&nbsp;Nthabeleng Molupe,&nbsp;Yolande I. Openda,&nbsp;John Mack,&nbsp;Tebello Nyokong","doi":"10.1016/j.pdpdt.2025.104781","DOIUrl":"10.1016/j.pdpdt.2025.104781","url":null,"abstract":"<div><div>This synthesis and photophysicochemical properties of two 2,6-diiodinated azaBODIPY dyes with thiomethylphenyl groups at the distal positions and phenyl (<strong>1</strong>) and naphthyl (<strong>2</strong>) rings at the proximal positions are reported. The dyes were conjugated to gold nanoparticles (<strong>1</strong>-AuNPs and <strong>2</strong>-AuNPs) to enhance their aqueous solubility for biomedical applications. Iodination at the 2,6-positions resulted in an enhancement of singlet oxygen generation, with singlet oxygen quantum yield (Φ_∆) values of 0.82 and 0.55 obtained in DMSO for <strong>1</strong> and <strong>2</strong>, respectively. The photodynamic antimicrobial chemotherapy (PACT) activities of the dyes were tested with a Thorlabs M660L3 light-emitting diode (LED) against <em>Staphylococcus aureus</em> after incubation at 5 µM. Conjugation to gold nanoparticles was found to significantly enhance the PACT activities against <em>Staphylococcus aureus</em>. Log₁₀ reduction values of 8.94 were obtained for <strong>1</strong>-AuNPs after 30 min irradiation (3.0 J.cm⁻²) and <strong>2</strong>-AuNPs after 60 min (6.0 J.cm⁻²).</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104781"},"PeriodicalIF":2.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic efficacy of highly aspherical lenslets combined with low-concentration atropine: A retrospective study","authors":"Guorui Hu ,&nbsp;Zhixing Xu ,&nbsp;Zhengyang Tao ,&nbsp;Zongyue Lv ,&nbsp;Weishan Li ,&nbsp;Zefeng Kang ,&nbsp;Hongwei Deng","doi":"10.1016/j.pdpdt.2025.104779","DOIUrl":"10.1016/j.pdpdt.2025.104779","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to evaluate the efficacy of 0.01 % atropine (AT), highly aspherical lenslets (HAL), and their combination in controlling myopia progression in children and adolescents.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted involving 144 children and adolescents aged 8 to 15 years who visited Shenzhen Eye Hospital between 2022 and 2024. Patients were categorized by refractive status into SE &gt; -2.00 D (-2.00D &lt; spherical equivalent [SE] ≤ -0.25D) and SE ≤ -2.00 D (SE ≤ -2.00D in at least one eye) groups. The SE &gt; -2.00 D group was further divided into AT, HAL, and HAL+AT subgroups, while the SE ≤ -2.00 D group was divided into HAL and HAL+AT subgroups. Data collected included best-corrected visual acuity, cycloplegic SE, and axial length. The Shapiro-Wilk test was used to assess normality. Baseline differences were analyzed with parametric and non-parametric tests. Generalized estimating equations (GEE) were applied to evaluate longitudinal SE changes across groups, followed by post hoc comparisons.</div></div><div><h3>Results</h3><div>In both the SE &gt; -2.00 D and SE ≤ -2.00 D groups, the final GEE model identified statistically significant differences based on treatment group, time, baseline average spherical equivalent of both eyes (SE-mean), and age (<em>p</em> &lt; 0.05). In the SE &gt; -2.00 D group, the HAL+AT group significantly slowed myopia progression by 0.338D compared to the AT group. The HAL group also significantly slowed myopia progression by 0.235D compared to the AT group. In the SE ≤ -2.00 D group, after adjusting for potential covariates, the HAL+AT group significantly slowed myopia progression by 0.247D compared to the HAL group.</div></div><div><h3>Conclusion</h3><div>Over one year, combining HAL with 0.01 % atropine effectively controlled myopia progression in children and adolescents with varying refractive statuses.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104779"},"PeriodicalIF":2.6,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal curvature in myopia: correlation with ocular physiological parameters","authors":"Siyu Yang,&nbsp;Ruibing Sun,&nbsp;Nan Xu,&nbsp;Lijiao Lu,&nbsp;Danyang Wang,&nbsp;Mingzhe Cao","doi":"10.1016/j.pdpdt.2025.104771","DOIUrl":"10.1016/j.pdpdt.2025.104771","url":null,"abstract":"<div><h3>Purpose</h3><div>Investigate the correlation of retinal curvature (RC) with ocular physiological parameters in myopic eyes.</div></div><div><h3>Method</h3><div>Clinical data from 332 patients (447 myopic eyes) were retrospectively analyzed. Eyes were classified into low myopia (LM), moderate myopia (MM), and high myopia (HM) groups based on spherical equivalent (SE) and axial length (AL). Ultra-widefield swept­source optical coherence tomography (UWF-SS-OCT) was used to acquire 24 × 20 mm OCT scans. Bruch’s membrane segmentation and AL-based correction produced a 3D retinal model. RC maps derived top curvature values (RC-MAX, RC-MID, RC-MIN) averaged as RC-AVE. Angiography quantified retinal vessel density (RVD), subfoveal choroidal thickness (SFCT), and choroidal parameters (CVI: choroidal vessel index; CSV/a: choroidal stromal volume per unit area; CVV/a: choroidal vascular volume per unit area) in macular and optic disc areas.</div></div><div><h3>Results</h3><div>RC-AVE decreased with myopia severity: LM: 1.02 (0.89, 1.14) × 10⁻²mm⁻², MM: 0.93 (0.83, 1.12) × 10⁻²mm⁻², HM: 0.76 (0.67, 0.90) × 10⁻²mm⁻². RC exhibited a significant negative correlation with AL (β = - 3.15, <em>p</em> &lt; 0.001) and significant positive correlations with SE (β = 5.34, <em>p</em> &lt; 0.001) and SFCT (β = 56.61, <em>p</em> = 0.001). In the macular region, RC positively correlated with choroidal vascular parameters CSV/a and CVV/a (β = 30.62, <em>p</em> = 0.005; β = 18.67, <em>p</em> = 0.002). In the optic disc region, RC showed significant positive associations with CVI, CSV/a, and CVV/a (β = 3.66, <em>p</em> &lt; 0.001; β = 49.56, <em>p</em> &lt; 0.001; β = 38.04, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>RC can quantitatively characterize retinal shape and the morphological changes induced by myopia. Significantly reduced RC in high myopia, with RC exhibiting negative correlations with AL and positive correlations with SE, SFCT, and vascular parameters.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104771"},"PeriodicalIF":2.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of macular microvascular changes in gestational diabetes mellitus","authors":"Mukaddes Damla Ciftci ,&nbsp;Filiz Afrashi ,&nbsp;Cumali Degirmenci ,&nbsp;Didem Gul Saritas ,&nbsp;Fuat Akercan","doi":"10.1016/j.pdpdt.2025.104770","DOIUrl":"10.1016/j.pdpdt.2025.104770","url":null,"abstract":"<div><h3>Background</h3><div>To evaluate retinal microvascular changes in GDM patients in the prepartum and postpartum periods with optical coherence tomography angiography (OCTA).</div></div><div><h3>Methods</h3><div>Forty-nine GDM patients (Group 1) and 39 healthy pregnant women (Group 2) were included in this study. Vascular density, foveal avascular zone (FAZ) area, and flow area were measured by OCTA. Twenty-four volunteers from Group 1 and 11 volunteers from Group 2 were re-evaluated after the 6th postpartum week.</div></div><div><h3>Results</h3><div>The mean age was 32.02±4.65 (23–42) in Group 1 and 30±5.66 (18–42) in Group 2. The average gestational week was 32.08±2.92 (23–38) and 31.31±3.51 (24–37) weeks in Group 1 and 2, respectively. Deep capillary plexus vascular density (DCP-VD) was found to be significantly lower in the GDM group (58.38±5.5 % and 60.52±3.75 %; <em>p</em> = 0.01). In the postpartum period, significant increase was observed in both superficial capillary plexus vascular density (SCP-VD) and DCP-VD in only the Group 1 when compared to the prepartum period, overtime (54.53±1.93 % and 53.04±2.83 %; 60.17±4.28 % and 58.38±5.5 %; <em>p</em> &lt; 0.001 and <em>p</em> = 0.018, respectively). When the correlation between the data obtained from OCTA and HbA1c values of a total of 88 volunteers in Group 1 and Group 2 was evaluated, a negative correlation was detected between choriocapillaris flow measurements and HbA1c values in the prepartum period (<em>p</em> = 0.05, ϱ=-0.22).</div></div><div><h3>Conclusion</h3><div>DCP-VD in GDM patients was lower than healthy pregnant women. It was shown that vascular density increases in both deep and superficial capillary plexus with the establishment of postpartum normoglycemia.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104770"},"PeriodicalIF":2.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of manual, image-guided, and femtosecond laser-assisted marking techniques for toric intraocular lens alignment","authors":"Fei Yang ,&nbsp;Yang Yu ,&nbsp;Xijuan Wang ,&nbsp;Jiayin Qin ,&nbsp;Xiaochun Li ,&nbsp;Yan Zhang ,&nbsp;Lisha Huang ,&nbsp;Xue Yang ,&nbsp;Yaqian Niu ,&nbsp;Mingwu Li ,&nbsp;Guangfeng Liu","doi":"10.1016/j.pdpdt.2025.104772","DOIUrl":"10.1016/j.pdpdt.2025.104772","url":null,"abstract":"<div><h3>Background</h3><div>To compare the visual outcomes and the accuracy of three axial marking techniques for toric intraocular lenses (IOLs): manual marking, the CALLISTO eye image-guided system and femtosecond laser-assisted capsulotomy marking.</div></div><div><h3>Methods</h3><div>A total of 105 eyes of 105 patients were enrolled in this retrospective comparative study. According to different axial marking methods, patients were assigned to the manual marking group (MM group), CALLISTO Eye image-guided system group (CE group) and femtosecond laser-assisted capsulotomy marking group (CM group). Uncorrected distant visual acuity (UCDVA), best corrected distant visual acuity, residual astigmatism, toric IOL misalignment, and modulation transfer function were measured and compared preoperatively and one month and three months postoperatively.</div></div><div><h3>Results</h3><div>Postoperative UCDVA and residual astigmatism were significantly lower in the CM group than in the MM group and CE group both at one month and three months postoperatively. IOL misalignment in the CM group was significantly less than that in the other two groups, and the CE group also performed better than the MM group. The AR values in the CE group and CM group were significantly higher than those in the MM group. Further correlation analysis found that postoperative UCDVA was positively correlated with residual astigmatism and IOL misalignment and negatively correlated with AR value. Postoperative residual astigmatism was positively correlated with IOL misalignment and negatively correlated with AR value.</div></div><div><h3>Conclusion</h3><div>Femtosecond laser-assisted capsulotomy marking provided the best visual outcomes and accurate alignment for toric IOLs. The CALLISTO eye image-guided marking performed moderately but slightly better than manual marking.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104772"},"PeriodicalIF":2.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors for postoperative macular microcirculation remodeling in idiopathic full–thickness macular hole","authors":"Jingling Zou ,&nbsp;Nan Wang ,&nbsp;Feng Zhang ,&nbsp;Haiyan Lian ,&nbsp;Jun Zeng ,&nbsp;Yan Yang","doi":"10.1016/j.pdpdt.2025.104767","DOIUrl":"10.1016/j.pdpdt.2025.104767","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the features of the macular microcirculation using optical coherence tomography angiography (OCTA) in surgically closed idiopathic full–thickness macular hole (IFTMH) and the correlated independent prognostic factors for postoperative macular microcirculation remodeling.</div></div><div><h3>Methods</h3><div>Twenty–seven eyes of 27 patients after successful IFTMH surgery that were followed for 6 months and 27 eyes of 27 age– and gender–matched healthy subjects were included. Patients with IFTMH and healthy subjects were examined using OCTA. Macular vessel density (VD), foveal avascular zone (FAZ) area of superficial capillary plexus (SCP), and flow area of outer retina and choroid were analyzed. Best–corrected visual acuity (BCVA) was evaluated before and 6 months after the surgery.</div></div><div><h3>Results</h3><div>The BCVA improved in eyes with IFTMH after the surgery (<em>p</em> &lt; 0.001). Postoperative VD was significantly lower in eyes with IFHMH compared with the normal control eyes (<em>p</em> &lt; 0.001). The mean flow area of the outer retina in eyes that underwent IFTMH surgery was significantly larger than normal control eyes (<em>p</em> &lt; 0.05), while the mean flow area of choroid capillary in postoperative IFTMH was significantly lower (<em>p</em> &lt; 0.01). Foveal VD was negatively correlated with both minimal and basal diameters (r = −0.473, <em>p</em> &lt; 0.05; r = −0.504, <em>p</em> &lt; 0.01). FAZ area was significantly positively correlated with both minimal and basal diameters (r = 0.635, <em>p</em> &lt; 0.001; r = 0.606, <em>p</em> &lt; 0.01). Additionally, the age of IFTMH was negatively correlated with the postoperative whole VD (r = –0.440, <em>p</em> &lt; 0.05) and positively correlated with the FAZ area (r = 0.382, <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Macular capillary plexuses observed by OCTA in eyes after IFTMH surgery had different characteristics compared to normal control eyes. Preoperative IFTMH characteristics can serve as prognostic factors for postoperative macular microcirculation remodeling.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104767"},"PeriodicalIF":2.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}