自适应光学扫描激光检眼镜对非动脉性前缺血性视神经病变的研究。

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-06-13 DOI:10.1016/j.pdpdt.2025.104678

Wenting Gu , Zizhong Hu , Weijie Chen , Qinghuai Liu , Yonghui Gu

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引用次数: 0

摘要

目的：探讨非动脉性前缺血性视神经病变（NAION）患者视锥感受器的变化。方法：采用自适应光学扫描激光检眼镜（AO-SLO）对NAION患者和健康人进行检查。急性NAION定义为病程2个月。我们分析了以3°偏心采集的2.4° × 2.4°锥体层图像的四个象限（相对于黄斑中央凹的上、下、鼻和颞象限）。通过光学相干断层扫描（OCT）进一步检查NAION患者。结果：正常眼与患眼乳头周围视网膜神经纤维层及神经节细胞层厚度差异有统计学意义（P < 0.05）。单眼NAION患者的AO-SLO数据显示，锥细胞在上、下、鼻、颞象限的密度、规律性和弥散性均无统计学差异（P < 0.05）。健康组、急性组和慢性组的密度差异无统计学意义（P < 0.05）。结论：AO-SLO在NAION患者中显示锥体完整性。从显微角度看，NAION可能不会影响视锥细胞的光感受器。

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Adaptive-optics scanning laser ophthalmoscopy study of non-arteritic anterior ischemic optic neuropathy

Objective

To investigate the changes in cone photoreceptors in patients with non-arteritic anterior ischemic optic neuropathy (NAION).

Methods

Adaptive-optics scanning laser ophthalmoscopy (AO-SLO) was performed in patients with NAION and healthy participants. Acute NAION was defined as a disease duration of <2 months, whereas chronic NAION was defined as a duration of >2 months. We analyzed four quadrants (superior, inferior, nasal, and temporal with respect to the central fovea of the macula) of the cone layer images at 2.4° × 2.4° collected at 3° eccentricity. Patients with NAION were further examined by using optical coherence tomography (OCT).

Results

Significant differences were observed in peripapillary retinal nerve fiber layer and ganglion cell layer thicknesses between the normal and affected eyes (P < 0.05). The AO-SLO data of patients with monocular NAION showed no statistical differences in the density, regularity, and dispersion of cone cells in the superior, inferior, nasal, and temporal quadrants (P > 0.05). No significant differences were noted in the density among the healthy, acute NAION, and chronic NAION groups (P > 0.05).

Conclusion

AO-SLO showed cone integrity in patients with NAION. From a microscopic perspective, NAION might not affect cone photoreceptors.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.