5-氨基乙酰丙酸光动力治疗宫颈3型转化区低级别鳞状上皮内病变疗效对比观察。

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-06-13 DOI:10.1016/j.pdpdt.2025.104679

Ruizhe Chen , Junfen Xu , Chun Ye , Lingjia Lu , Ying Li , Lingfang Wang , Xiaodong Cheng , Yunfeng Fu

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引用次数: 0

摘要

背景：宫颈低级别鳞状上皮内病变（LSIL）和3型转化区（TZ）患者的治疗存在局限性。本研究的目的是比较新方法5-氨基乙酰丙酸光动力疗法（ALA-PDT）和观察在这些患者中的疗效。方法：本研究回顾性分析了236例（25-45岁）宫颈LSIL和3型TZ患者的资料。患者分为ALA-PDT组和观察组，诊断后随访1年。比较结果，分析影响LSIL消退和人乳头瘤病毒（HPV）清除率的因素。结果：ALA-PDT组LSIL消退率为89.8%，显著高于观察组68.4% (p)。结论：ALA-PDT能有效促进LSIL消退和HPV清除率。对于3型TZ、持续性LSIL和高危HPV感染的女性，ALA-PDT可能被认为是一种可行的治疗选择，ALA-PDT的疗效不受临床特征的影响，提示其对具有多种临床危险因素的患者有益。

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Efficacy of 5-aminolevulinic acid photodynamic therapy versus observation for cervical low-grade squamous intraepithelial lesion with type 3 transformation zone

Background

The treatment for patients with cervical low-grade squamous intraepithelial lesion (LSIL) and type 3 transformation zone (TZ) had limitations. The aim of this study was to compare the efficacy of new approach 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and observation in those patients.

Methods

This study retrospectively analyzed data from 236 patients (aged 25–45 years) with cervical LSIL and type 3 TZ. Participants were divided into ALA-PDT and observation groups, and were followed up for 1-year post-diagnosis. Outcomes were compared and factors influencing LSIL regression and human papillomavirus (HPV) clearance were analyzed.

Results

The LSIL regression rate was 89.8 % in the ALA-PDT group, significantly higher than 68.4 % in the observation group (P < 0.05). The ALA-PDT group demonstrated a significantly higher HPV clearance rate of 69.5 % compared to 39.0 % in the observation group (P < 0.05). No significant correlation was found between baseline clinical characteristics and LSIL regression or HPV clearance in either group.

Conclusion

ALA-PDT is effective in promoting LSIL regression and HPV clearance. ALA-PDT may be considered as a viable treatment option for women with type 3 TZ, persistent LSIL and high-risk HPV infection, The efficacy of ALA-PDT is not affected by clinical characteristics, suggesting its benefit for patients with various clinical risk factors.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.