Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Interpreting RNFL thinning and age subgroups in keratoconus: clarifying model choice, effect-size considerations, and quality appraisal","authors":"Hadi Vahedi","doi":"10.1016/j.pdpdt.2025.105270","DOIUrl":"10.1016/j.pdpdt.2025.105270","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105270"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of magnesium-conditioned chitosan hydrogels and photobiomodulation on MC3T3-E1 preosteoblast function","authors":"Hao-Hsuan Chiu ,&nbsp;Pei-Chun Wong ,&nbsp;Ying-Chun Chen","doi":"10.1016/j.pdpdt.2025.105307","DOIUrl":"10.1016/j.pdpdt.2025.105307","url":null,"abstract":"<div><h3>Background</h3><div>Magnesium (Mg) and photobiomodulation (PBM) have independently been reported to promote osteogenesis, but their combined effects remain unclear.</div></div><div><h3>Methods</h3><div>Mg-conditioned chitosan hygrogels (0,20, and 50 mol%) were prepared, and conditioned media were applied to MC3T3-E1 preosteoblasts with or without near-infrared PBM (830 nm, 5 J/cm²). Cell viability, migration, and calcium deposition were assessed (<em>n</em> = 3 biological replicates per group).</div></div><div><h3>Results</h3><div>High Mg reduced cell migration and mineralization, whereas PBM significantly enhanced calcium deposition and partially restored viability at early time points (<em>p</em> &lt; 0.05). A notable synergistic effect was observed at 20 mol% Mg combined with PBM, particularly at specific time points, indicating a condition-dependent rather than uniformly optimal response.</div></div><div><h3>Conclusion</h3><div>The combination of Mg-conditioned hydrogels and PBM enhanced osteogenic responses in MC3T3-E1 preosteoblasts. This dual-modality strategy may inform scaffold design in bone tissue engineering.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105307"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145703591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Er Cr: YSGG laser, ytterbium fiber laser, and Rose Bengal-activated low-level laser therapy on roughness and shear bond strength of yttria-stabilized zirconia","authors":"Ghadeer I Basunbul","doi":"10.1016/j.pdpdt.2025.104784","DOIUrl":"10.1016/j.pdpdt.2025.104784","url":null,"abstract":"<div><h3>Aim</h3><div>Effect of Er Cr: YSGG laser (ECL), ytterbium fiber laser (YFL), Rose Bengal (RB) activated low-level laser therapy (LLLT) on the surface roughness (Ra) and shear bond strength (SBS) of yttrium-stabilized tetragonal zirconia polycrystal (Y-TZP) bonded to resin cement.</div></div><div><h3>Materials and methods</h3><div>Sixty-four 3Y-TZP discs were prepared, and subsequently, categorized into four distinct groups based on the conditioning regimen (<em>n</em> = 16): Group 1 (SB), Group 2 (ECL), Group 3 (YFL), and Group 4 (LLLT-RB). The Ra assessment was performed on five samples from each group using a profilometer. One specimen from each group was subjected to surface topography analysis under a scanning electron microscope (SEM). A self-adhesive resin cement was built on ten samples from each group and photo polymerized, followed by artificial ageing. The SBS and failure modes were assessed using a universal testing machine and a stereomicroscope, respectively. The data was evaluated using ANOVA and a post hoc test, <em>p</em> = 0.05.</div></div><div><h3>Results</h3><div>Samples surface treated with YFL attained the highest Ra scores (1334.32 ± 0.065 µm) and highest bond strength (9.34±0.29 MPa). In contrast, the 3Y-TZP discs surface treated with LLLT-RB exhibited the lowest Ra value (870.56 ± 0.076 µm) and the lowest bond values (5.76±0.34 MPa). Zirconia disc surface treated with ECL and SB groups demonstrated admixed failures. LLLT (RB), on the other hand, exhibited adhesive fractures with the highest frequency.</div></div><div><h3>Conclusion</h3><div>Ytterbium fiber laser displayed the most satisfactory performance in terms of improving surface roughness and shear bond strength of zirconia with the resin cement, and can be used as an alternative surface pretreating regime for zirconia.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 104784"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monte Carlo-based estimation of NIR-PDT efficacy with and without breast compression in early-stage breast cancer","authors":"Yugo Minegishi,&nbsp;Yasutomo Nomura","doi":"10.1016/j.pdpdt.2025.105330","DOIUrl":"10.1016/j.pdpdt.2025.105330","url":null,"abstract":"<div><h3>Introduction</h3><div>Near-infrared photodynamic therapy (NIR-PDT) for early-stage breast cancer has attracted attention and it suggests that the depth of the tumor from the skin surface significantly affects treatment efficacy, with shallower tumors responding more effectively to therapy. Therefore, compressing the breast, as is done during mammography, may improve therapeutic outcomes by reducing tumor depth. In this study, we investigated the effectiveness of breast compression in NIR-PDT for early-stage breast cancer using Monte Carlo simulations.</div></div><div><h3>Methods</h3><div>We evaluated the impact of breast compression on the effectiveness of NIR-PDT for early-stage breast cancer through Monte Carlo simulations. Sixty pairs of digital breast phantoms representing uncompressed and compressed states were generated, and spherical tumors with a 7 mm diameter were embedded under appropriate conditions in 15 of these pairs. The propagation of excitation light at an intensity of 330 mW/cm², a level considered safe for skin tissue, was then analyzed. Based on the computed excitation fluence, the corresponding amount of singlet oxygen produced was estimated to assess NIR-PDT efficacy.</div></div><div><h3>Results</h3><div>The simulations indicated that breast compression substantially reduced tumor depth, with an average decrease of 5 mm across the 15 pairs. Consequently, the number of irradiation sessions required for complete treatment was reduced by an average of 19. In 8 of the 15 phantoms, the number of treatment irradiation cycles was reduced to five or fewer, suggesting clinical feasibility.</div></div><div><h3>Conclusion</h3><div>These results demonstrate that applying appropriate breast compression can enhance the therapeutic performance of NIR-PDT for early-stage breast cancer.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105330"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction or early detection? Clarifying ectasia ML models","authors":"Henry Bair","doi":"10.1016/j.pdpdt.2026.105335","DOIUrl":"10.1016/j.pdpdt.2026.105335","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105335"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphologic and functional assessment of photoreceptors in anisometropic amblyopia using adaptive optics scanning laser ophthalmoscopy","authors":"Hang Yang ,&nbsp;Maoxia Lv ,&nbsp;Jie Peng,&nbsp;Qian Luo,&nbsp;Zhengzheng Wu,&nbsp;Tong Yan,&nbsp;Yanxi Xie,&nbsp;Jing Li,&nbsp;Yin Yang,&nbsp;Lin Zhou","doi":"10.1016/j.pdpdt.2025.105241","DOIUrl":"10.1016/j.pdpdt.2025.105241","url":null,"abstract":"<div><h3>Objective</h3><div>Using adaptive optics scanning laser ophthalmoscopy (AO-SLO) to investigate the cone photoreceptor structure in children with anisometropic amblyopia and to examine its correlation with contrast sensitivity function (CSF).</div></div><div><h3>Methods</h3><div>Fifteen patients with monocular anisometropic amblyopia (amblyopic eyes, AE; fellow eyes, FE) and 15 age-matched controls (normal eyes, NE) were enrolled (45 eyes). Data on macular cone photoreceptor density, spacing, and regularity; retinal and choroidal thickness; superficial capillary plexus vessel density (SCP-VD); choroidal vascularity index (CVI); and contrast sensitivity function (CSF) were collected. Statistical analyses were performed using one-way analysis of variance (ANOVA), Pearson correlation, and multivariate linear regression.</div></div><div><h3>Results</h3><div>Compared to the FE and NE groups, the AE group showed significantly reduced cone density (28,519.12 ± 2853.41 vs. 35,529.21 ± 2217.35 and 36,181.62 ± 3081.95 cells/mm², <em>P</em> &lt; 0.01), increased spacing (6.36 ± 1.64 vs. 4.22 ± 0.41 vs. 4.13 ± 0.50 μm, <em>P</em> &lt; 0.01), and decreased regularity (92.99 ± 1.49 % vs. 95.86 ± 1.20 % vs. 95.90 ± 1.03 %; <em>P</em> &lt; 0.01). The Area Under the Log Contrast Sensitivity Function (AULCSF) of the AE group (1.61 ± 0.08) was significantly lower than that of the FE (1.84 ± 0.04) and NE groups (1.87 ± 0.08; <em>P</em> &lt; 0.01). CSF was positively correlated with cone density (<em>R²</em> = 0.899, <em>P</em> &lt; 0.001) and regularity (<em>R²</em> = 0.530, <em>P</em> = 0.002) and negatively correlated with cone spacing (<em>R²</em> = 0.539, <em>P</em> = 0.002). Multivariate regression analysis revealed that cone density (<em>β</em> = 0.701, <em>P</em> &lt; 0.001) and cone regularity (<em>β</em> = 0.228, <em>P</em> = 0.026) had a positive predictive effect on AULCSF.</div></div><div><h3>Conclusion</h3><div>Anisometropic amblyopia shows disrupted macular cone structure, including reduced density and irregular spacing, which closely relates to impaired contrast sensitivity. AO-SLO can help assess these retinal deficits in developmental visual disorders.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105241"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OCT-based retinal biomarkers forecast central nervous system structural decline in Parkinson’s disease: A longitudinal multimodal study within the Persian Cohort","authors":"Farzane Nikparast ,&nbsp;Nooshin Akbari-Sharak ,&nbsp;Zohreh Ganji ,&nbsp;Ali Shoeibi ,&nbsp;Naser Shoeibi ,&nbsp;Hoda Zare","doi":"10.1016/j.pdpdt.2025.105310","DOIUrl":"10.1016/j.pdpdt.2025.105310","url":null,"abstract":"<div><h3>Background and Objective</h3><div>Parkinson's disease (PD) is among the most prevalent progressive neurodegenerative disorders, impacting both the central and peripheral nervous systems.This longitudinal study investigates whether structural changes in the retina, due to its developmental and structural similarities with the brain, can act as early indicators of brain alterations in patients with PD.</div></div><div><h3>Methods</h3><div>Data from 29 PD patients and 25 healthy controls were analyzed. After a mean interval of 2.7 years after retina imaging, all participants underwent a 1.5T magnetic resonance imaging (MRI) Scan. Image processing was performed using 3D Slicer and the CAT12 toolbox, while statistical analyses were conducted with R software.</div></div><div><h3>Results</h3><div>In healthy controls, a significant positive correlation was observed between gray and white matter volumes and peripapillary retinal nerve fiber layer (pRNFL) thickness (r = 0.5, p &lt; 0.05) and (r = 0.4, p &lt; 0.05). In contrast, PD patients showed a significant association between increased CSF volume and reduced pRNFL thickness and optic nerve rim volume (r = -0.50 to -0.40; p &lt; 0.05) and (r = -0.50; p &lt; 0.05), respectively. Moreover, neuromelanin signal intensity in the substantia nigra correlated positively and significantly with pRNFL thickness in nasal and superior sectors exclusively in the PD group (r = 0.40 to 0.60; p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Retinal alterations in PD are closely aligned with concurrent brain neurodegeneration and may serve as predictive biomarkers. These findings suggest that OCT, when combined with MRI, may support a non-invasive strategy for early risk stratification and longitudinal monitoring of PD.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105310"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SS-OCTA versus ICGA: a comparison of detection efficiency for large choroidal vein patterns in AMD patients","authors":"Nianjia Wang ,&nbsp;Xindi Liu ,&nbsp;Jiayi Wu ,&nbsp;Xintong Xiang ,&nbsp;Yujia Gao ,&nbsp;Liang Yao ,&nbsp;Xin Wang","doi":"10.1016/j.pdpdt.2025.105303","DOIUrl":"10.1016/j.pdpdt.2025.105303","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the efficacy of swept-source optical coherence tomography angiography (SS-OCTA) and indocyanine green angiography (ICGA) in visualizing and classifying large choroidal vein topography, and to evaluate the association between specific venous patterns and pachychoroid spectrum disease (PSD)-associated macular neovascularization (MNV).</div></div><div><h3>Methods</h3><div>This retrospective cross-sectional study included 222 eyes from 160 patients with neovascular age-related macular degeneration (nAMD). All participants underwent both SS-OCTA and ICGA imaging. Choroidal venous patterns were classified into four types based on ICGA venous phase images: watershed, anastomotic, upper thicker, and lower thicker. SS-OCTA images were processed and analyzed using Fiji software. Diagnostic agreement between modalities was assessed using Cohen’s Kappa. Logistic regression was used to evaluate the association between venous patterns and disease subtypes.</div></div><div><h3>Results</h3><div>SS-OCTA and ICGA showed almost perfect agreement in classifying choroidal venous patterns in discernible cases (unweighted Kappa = 0.978). Among 77 eyes where ICGA failed to provide a clear classification, SS-OCTA achieved a definitive diagnosis in 87.0 % (P &lt; 0.001), with the anastomotic type being the most common. Furthermore, the watershed pattern was significantly more prevalent in non-PCV nAMD compared to PCV (29.8 % vs. 12.1 %, p = 0.002), suggesting distinct choroidal venous backgrounds between these subtypes.</div></div><div><h3>Conclusion</h3><div>SS-OCTA provides a reliable, non-invasive alternative to ICGA for visualizing and classifying large choroidal veins, with superior performance in cases obscured by hemorrhage or leakage. The distinct distribution of venous patterns across nAMD subtypes highlights the potential role of choroidal venous architecture in disease phenotyping and pathogenesis.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105303"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on “clinical outcomes of selective laser trabeculoplasty in military pilots with open-angle glaucoma: Implications for intraocular pressure control and aeromedical certification”","authors":"Shashank Dokania,&nbsp;Parth Aphale,&nbsp;Himanshu Shekhar","doi":"10.1016/j.pdpdt.2025.105281","DOIUrl":"10.1016/j.pdpdt.2025.105281","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105281"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145484346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scleral iontophoresis for targeted lutein delivery in intermediate stage dry AMD: Is this a new frontier in age macular degeneration?","authors":"Michele Rinaldi ,&nbsp;Gilda Cennamo ,&nbsp;Gaetano Fioretto ,&nbsp;Maria Laura Passaro ,&nbsp;Fulvia De Falco ,&nbsp;Matteo Bertocchi ,&nbsp;Maddalena Marotta ,&nbsp;Flavia Chiosi ,&nbsp;Francesco Calabro ,&nbsp;Diego Strianese ,&nbsp;Ciro Costagliola","doi":"10.1016/j.pdpdt.2026.105356","DOIUrl":"10.1016/j.pdpdt.2026.105356","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the retinal morphofunctional changes in patients with stage 2 age-related macular degeneration (AMD) following scleral iontophoresis for lutein delivery, and to assess its safety.</div></div><div><h3>Methods</h3><div>In this prospective, non-randomized, single-arm pilot study, 30 stage 2 AMD patients (mean age 71.6 ± 10.88 years) received scleral iontophoresis with a liquid lutein formulation. Comprehensive ophthalmologic assessments—including best-corrected visual acuity (BCVA), macular pigment optical density (MPOD) via one-wavelength reflectometry, and microperimetry (mean sensitivity, mean defect, and fixation stability measured as BCEA)—were performed at baseline and at 6 months. Adverse events were monitored, and ocular surface health was assessed using the Ocular Surface Disease Index (OSDI).</div></div><div><h3>Results</h3><div>At 6 months, MPOD significantly increased from 0.169 ± 0.06 to 0.180 ± 0.075 density units (p = 0.0313). Mean sensitivity improved from 7.26 ± 5.13 dB to 8.18 ± 4.57 dB (p = 0.0179), and mean defect improved from –11.48 ± 4.90 dB to –10.27 ± 3.76 dB (p = 0.0207). Fixation stability, as measured by BCEA at 3 standard deviations, significantly decreased (p = 0.0107). No significant change was observed in BCVA, and OSDI scores remained stable. No adverse events were reported.</div></div><div><h3>Conclusions</h3><div>Scleral iontophoresis of lutein is a safe and promising technique to enhance local MPOD and retinal sensitivity in intermediate AMD patients. Further studies with larger cohorts are warranted to confirm these preliminary findings.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105356"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}