Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Choroidal structural alterations in patients with type 2 diabetes mellitus without clinical diabetic retinopathy using ultra-widefield swept-source OCTA: A cross-sectional study","authors":"Cong Chen ,&nbsp;Wen-Jing Zhang ,&nbsp;Qin Ding ,&nbsp;Shu-Min Shen ,&nbsp;Ya Ye ,&nbsp;Zhen Huang ,&nbsp;Ming Yan ,&nbsp;Yan-Ping Song","doi":"10.1016/j.pdpdt.2026.105349","DOIUrl":"10.1016/j.pdpdt.2026.105349","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to quantitatively examine choroidal structural alterations in patients with type 2 diabetes mellitus (T2DM) of varying disease duration who did not present with clinical diabetic retinopathy (DR), using ultra-widefield swept-source optical coherence tomography angiography (UWF-SS-OCTA).</div></div><div><h3>Methods</h3><div>This cross-sectional study included 200 patients with T2DM without DR (200 eyes) and 78 healthy individuals (78 eyes). Based on diabetes duration, patients were categorized into three groups: &lt;5 years (DM1, <em>n</em> = 80), 5 to 10 years (DM2, <em>n</em> = 60), and &gt;10 years (DM3, <em>n</em> = 60). UWF-SS-OCTA was used to quantify choroidal thickness (CT), choroidal vascular volume (CVV), and choroidal vascularity index (CVI) in the peripapillary region, the macula-centered UWF central area (1–12 mm), and the peripheral area (12–21 mm). One-way analysis of variance with post hoc testing assessed intergroup differences. Multivariable linear regression was performed to evaluate the associations between diabetes duration and choroidal parameters.</div></div><div><h3>Results</h3><div>Relative to healthy controls, patients in the DM3 group exhibited significant reductions in CT and CVV in all evaluated regions, along with decreases in CVI in most regions (all <em>p</em> &lt; 0.05). When diabetic subgroups were compared, the DM3 group demonstrated significantly lower CT and CVV across all regions compared with the DM1 and DM2 groups (all <em>p</em> &lt; 0.05). Central CVI showed a progressive decline with longer diabetes duration, while peripheral CVI differed significantly only between the DM3 and DM1 groups. Except for peripheral CVI, CT, CVV, and central CVI across all assessed regions were independently and negatively associated with diabetes duration (all <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Patients with T2DM without DR demonstrated early choroidal thinning and vascular deterioration, which progressively worsened with longer diabetes duration. UWF-SS-OCTA revealed that the choroidal alterations in T2DM without DR were widespread but most pronounced in the peripheral regions, highlighting the importance of wide-field imaging for comprehensive assessment.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105349"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic analysis reveals the molecular mechanisms of methylene blue-mediated photodynamic therapy against Microsporum canis","authors":"Gaoyuan Peng ,&nbsp;Weilun Xu ,&nbsp;Shulei Qin ,&nbsp;Junmeng Zhou ,&nbsp;Kaisu Pan ,&nbsp;Lan Huang ,&nbsp;Dongyan Zheng ,&nbsp;Xinyu Zhang","doi":"10.1016/j.pdpdt.2026.105364","DOIUrl":"10.1016/j.pdpdt.2026.105364","url":null,"abstract":"<div><h3>Background</h3><div>Microsporum canis is a predominant cause of dermatophytosis, presenting a significant therapeutic challenge due to the limitations of conventional antifungal agents and the emergence of drug resistance. Methylene Blue-mediated Photodynamic Therapy (MB-PDT) represents a promising alternative; however, the comprehensive transcriptomic response and specific molecular pathways disrupted by this modality in M. canis remain largely elusive.</div></div><div><h3>Methods</h3><div>This study employed RNA-sequencing (RNA-Seq) to elucidate the global transcriptomic response of M. canis to a sub-inhibitory concentration of MB-PDT. Differentially expressed genes (DEGs) were identified, and their biological functions were characterized via Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Furthermore, the expression profiles of key marker genes were validated using qRT-PCR.</div></div><div><h3>Results</h3><div>A total of 619 DEGs were identified, comprising 341 upregulated and 278 downregulated genes. Functional enrichment analysis highlighted the \"ribosome\" and \"steroid biosynthesis\" pathways as the most significantly impacted. The transcriptomic profile suggests that MB-PDT induces multi-target oxidative damage, specifically compromising cell membrane integrity, mitochondrial function, and ribosomal activity. Notably, the expression patterns of key marker genes indicate that M. canis activates an intrinsic programmed cell death (PCD) pathway in response to this irreparable oxidative stress.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that MB-PDT exerts its antifungal effect against <em>M. canis</em> through a multi-target mechanism that overwhelms cellular repair systems, ultimately triggering the initiation of PCD. This mode of action may mitigate the risk of resistance development, underscoring MB-PDT as a potent therapeutic alternative for the management of dermatophytosis.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105364"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Agent-Specific Differences in Sustained Intraoperative Hypotension during oral 5-Aminolevulinic Acid-Guided Transurethral Resection of Bladder Tumor: A Retrospective Observational Study” [Photodiagnosis and Photodynamic Therapy 57C (2026) 105319]","authors":"Yoshifumi Katsumata ,&nbsp;Shinkuro Yamamoto ,&nbsp;Hideki Iwata ,&nbsp;Hajime Kuroiwa ,&nbsp;Hideo Fukuhara ,&nbsp;Satoshi Fukata ,&nbsp;Keiji Inoue ,&nbsp;Takashi Kawano","doi":"10.1016/j.pdpdt.2026.105358","DOIUrl":"10.1016/j.pdpdt.2026.105358","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105358"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146128036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Retinal microvascular changes in patients recovered from COVID-19 compared to healthy controls: a meta-analysis” [Photodiagnosis and Photodynamic Therapy 42C (2023)103556]","authors":"Dimitrios Kazantzis,&nbsp;Genovefa Machairoudia,&nbsp;George Theodossiadis,&nbsp;Panagiotis Theodossiadis,&nbsp;Irini Chatziralli","doi":"10.1016/j.pdpdt.2026.105377","DOIUrl":"10.1016/j.pdpdt.2026.105377","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105377"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effect of photodynamic therapy with multimodal therapy achieves anus preservation in MSS ultra-low rectal cancer—A case report and literature review","authors":"Jing Liu ,&nbsp;Lingzhi Liao ,&nbsp;Jiahui Ma ,&nbsp;Jingwei Ma ,&nbsp;Yali Li ,&nbsp;Yile Qi ,&nbsp;Baohong Gu ,&nbsp;Jike Hu ,&nbsp;Ewetse Paul Maswikiti ,&nbsp;Hao Chen","doi":"10.1016/j.pdpdt.2025.105299","DOIUrl":"10.1016/j.pdpdt.2025.105299","url":null,"abstract":"<div><div>The preservation of the anus in ultra-low rectal cancer (ULRC) surgery presents considerable clinical challenges. While combined neoadjuvant therapy is considered a pivotal treatment strategy, its effectiveness is constrained by factors such as anatomical location, postoperative complications, systemic toxic reactions, and tumor drug resistance. Photodynamic therapy (PDT), as a localized treatment modality, operates through multiple mechanisms, including the targeted eradication of tumor cells, disruption of the tumor vascular system, reversal of drug resistance, and activation of antitumor immune responses. This article presents a case study of a patient with stage IIIb (cT4N1Mx), microsatellite stable (MSS) ULRC, who successfully achieved tumor downstaging and underwent anus-preserving surgery following a comprehensive treatment regimen. This regimen included PDT, systemic therapy, da Vinci robot-assisted anus-preserving surgery, and anastomotic stent implantation. The patient has achieved a progression-free survival (PFS) exceeding 14 months. At present, the patient exhibits satisfactory defecation function, and no complications, such as anastomotic fistula, have been observed.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105299"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hexylaminolevulinic acid in precision medicine: A review of advances in drug delivery and combination therapeutics","authors":"Lijiang Gu ,&nbsp;Pan Zhang ,&nbsp;Yibo Mei ,&nbsp;Zhongyu Wang ,&nbsp;Dalin He","doi":"10.1016/j.pdpdt.2026.105371","DOIUrl":"10.1016/j.pdpdt.2026.105371","url":null,"abstract":"<div><div>Hexylaminoacetylpropionic acid (HAL), a third-generation photosensitizer prodrug, exhibits targeted accumulation within tumor tissues and microbial biofilms. This review outlines advances in HAL-based drug delivery systems and their expanding use in various diseases, including oncology, antimicrobial therapy, and dermatologic diseases. Clinically, HAL has proven instrumental in enhancing diagnostic accuracy for bladder cancer by facilitating more complete surgical resections, while also demonstrating therapeutic efficacy against actinic keratosis and cervical intraepithelial neoplasia. These clinical advantages are complemented by novel nanocarrier systems that optimize drug delivery that improve patient tolerability. Recent findings point to an underappreciated the interplay between HAL-induced metabolic changes in tumours and anti-tumour immune responses, in which HAL-induced metabolic changes in tumours and anti-tumour immune responses, in which HAL-induced induces cell apoptosis through mitochondrial membrane permeabilization and the nuclear translocation of AIF, and enhances the efficacy of immune checkpoint blockade of key regulatory proteins reshape the tumour microenvironment and enhance immunogenicity. Thus, HAL is a candidate for combination with immune checkpoint inhibitors. However, challenges such as shallow light penetration (&lt;2 mm) and the need for long-term safety validation limit its broader clinical utility. We propose three convergent strategies to address these limitations: (i) reactive oxygen species-responsive nanocarriers for targeted delivery in hypoxic environments, (ii) biomarker-guided combinatorial regimens, and (iii) data-driven treatment personalisation using patient-specific biomarkers. Together, these advances establish a translational framework for HAL as a platform in next-generation metabolism-targeted photomedicine.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105371"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Milk-derived exosomes (MDE) for photosensitizer delivery in photodynamic therapy: A review","authors":"Kave Moloudi ,&nbsp;Nkune Williams Nkune ,&nbsp;Heidi Abrahamse ,&nbsp;Blassan P. George","doi":"10.1016/j.pdpdt.2026.105370","DOIUrl":"10.1016/j.pdpdt.2026.105370","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) is a novel light-based modality that relies on photoactivatable photosensitizers (PSs) to generate cytotoxic reactive oxygen species (ROS), but its clinical prospects are impeded by issues related to poor tumour specificity, penetration and off-target phototoxicity. Milk-derived exosomes (MDE), naturally occurring extracellular vesicles (30–150 nm in diameter) with excellent biocompatibility and low immunogenicity, have recently emerged as promising vehicles in drug delivery. MDE enhance intercellular communication by transporting proteins, lipids, and nucleic acids between cells. They have gained significant attention in recent years for their potential use in drug delivery, particularly for hydrophobic PSs, gene and protein delivery. MDE are of particular interest due to their abundance, ease of isolation, and biocompatibility. Herein we reviewed recent developments in MDE-mediated PDT, with a focus on three key areas: isolation and loading techniques, stimuli-responsive release and targeting such as pH-sensitive linkers or surface-anchored ligands (<em>e.g.</em>, folic acid), therapeutic applications and <em>in vivo</em> efficacy. Several lines of evidence showed that MDE loaded with PSs significantly enhance tumour uptake and cause severe regression <em>in vivo</em> tumour models of glioblastoma and oral cancer, following systemic or oral administration. Overall findings from this review suggest that clinical translation depends on addressing key challenges related to scalable purification, reproducible drug loading and thorough safety profile screening. Therefore, it is essential for researchers to actively standardize manufacturing processes, conduct thorough <em>in vivo</em> validation, and investigate combination therapies with modalities for enhanced therapeutic efficacy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105370"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of the cycloplegic vision screener V100 and desktop autorefractometer compared to retinoscopy in children: A comparative study with literature findings","authors":"Mahmut Dogan ,&nbsp;Zekeriya Cetinkaya","doi":"10.1016/j.pdpdt.2026.105338","DOIUrl":"10.1016/j.pdpdt.2026.105338","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the cycloplegic accuracy of the Vision Screener V100 (VS) and a desktop autorefractometer (TAR) in comparison with cycloplegic retinoscopy (CR) in children, and to compare the findings with current literature.</div></div><div><h3>Methods</h3><div>This prospective observational study included 50 pediatric patients (100 eyes) with a mean age of 9.8 ± 1.7 years. Cycloplegic measurements were obtained using the VS, TAR, and CR. Agreement between methods was analyzed using intraclass correlation coefficients (ICC) and Bland–Altman plots. Differences in spherical and cylindrical values were specifically assessed.</div></div><div><h3>Results</h3><div>TAR showed excellent agreement with CR, with ICC values above 0.95 for both spherical and cylindrical measurements. In contrast, the VS demonstrated moderate correlation for spherical values (ICC ≈ 0.82) and lower correlation for cylindrical values (ICC ≈ 0.60). Bland–Altman plots revealed that TAR had narrower limits of agreement with CR, particularly for astigmatism, whereas VS showed wider variability. These findings are consistent with previous reports indicating that non-cycloplegic photoscreening devices such as the VS tend to underestimate hyperopia and show reduced reliability in astigmatism assessment.</div></div><div><h3>Conclusion</h3><div>TAR demonstrates excellent concordance with CR under cycloplegia, whereas the VS shows notably lower accuracy, especially in detecting astigmatism. Our results highlight the importance of cycloplegic evaluation for accurately assessing refractive errors in children.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105338"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic therapy for glans penis verrucous xanthoma: A novel, scar-free approach","authors":"XH Lu ,&nbsp;GL Ke ,&nbsp;WY Zhang ,&nbsp;T Hani ,&nbsp;VC Cleopatra ,&nbsp;J Wang ,&nbsp;Tao Yuan ,&nbsp;XL Chang ,&nbsp;CF He","doi":"10.1016/j.pdpdt.2026.105367","DOIUrl":"10.1016/j.pdpdt.2026.105367","url":null,"abstract":"<div><div>Verrucous xanthoma is an uncommon skin condition, most frequently occur in the oral cavity and other sites [<span><span>1</span></span>], and its occurrence on the glans penis is especially rare. Conventional treatment methods such as surgical excision or laser therapy often carry a risk of scarring, which may reduce glans sensitivity and negatively impact sexual function. This case report describes a successful outcome using 5-ALA PDT as a non-invasive treatment.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105367"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world outcomes of photoimmunotherapy for oral sites in head and neck cancer: A multicentre subgroup analysis","authors":"On Hasegawa ,&nbsp;Isaku Okamoto ,&nbsp;Yukiomi Kushihashi ,&nbsp;Tatsuo Masubuchi ,&nbsp;Kunihiko Tokashiki ,&nbsp;Kiyoaki Tsukahara","doi":"10.1016/j.pdpdt.2026.105360","DOIUrl":"10.1016/j.pdpdt.2026.105360","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate clinical outcomes and supportive-care needs in photoimmunotherapy (PIT) restricted to oral sites in a multicentre real-world cohort.</div></div><div><h3>Methods</h3><div>We retrospectively analysed 40 consecutive patients with unresectable, locally recurrent head and neck cancer undergoing PIT between 1 January 2021 and 31 August 2024. The oral-site subgroup comprised 12 patients receiving ≥1 illumination to the oral cavity (tongue, gingiva, buccal mucosa, floor of mouth, hard palate, or flap). The primary endpoint was objective response rate (ORR). Secondary endpoints included time-to-treatment failure (TTF), overall survival (OS), progression-free survival (PFS), and adverse events (AEs). Kaplan–Meier analyses assessed time-to-event outcomes.</div></div><div><h3>Results</h3><div>Best overall responses comprised complete response, partial response, stable disease, and progressive disease in six, four, one, and one patients, respectively, yielding an ORR of 83.3 % (95 % confidence interval [CI], 51.6–97.9) and a disease control rate of 91.7 % (95 % CI, 61.5–99.8). The median TTF, OS, and PFS were 6.0 months (95 % CI, 1.4–18.3), 22.0 months (95 % CI, 6.0–unreached), and 6.0 months (95 % CI, 1.4–10.4), respectively. AEs included pain (100 %; grade≥3, 25 %), mucositis (92 %; grade≥3, 17 %), facial oedema (75 %), laryngeal oedema (67 %; grade≥3, 8 %), dysphagia (50 %), bleeding (50 %), and fistula (33 %). Commonly required supportive interventions included anticipatory analgesia, airway protection (e.g., preventive tracheostomy), and temporary enteral nutrition.</div></div><div><h3>Conclusions</h3><div>Oral-site PIT demonstrated high antitumour activity with frequent but manageable local toxicities, necessitating proactive, multidisciplinary supportive care. This first dedicated multicentre analysis focused on oral illumination corroborates site-specific PIT evaluation and its integration within multimodal treatment strategies.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105360"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}