Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Facial verrucous epidermal nevus with pruritus: Successfully treated with photodynamic therapy","authors":"Qiying Zhang ,&nbsp;Kaili Chen ,&nbsp;Xuefeng Fu ,&nbsp;Meiyan Wang ,&nbsp;Qi Tu ,&nbsp;Yanfei Zhang","doi":"10.1016/j.pdpdt.2025.104785","DOIUrl":"10.1016/j.pdpdt.2025.104785","url":null,"abstract":"<div><div>Verrucous epidermal nevus (VEN) is uncommon and is typically present at birth. The disorder is essentially cosmetic and is found more often in females which features were brown and skin-colored verrucous papules or plaques distributed linearly along Blaschko’s lines. VEN on the face often adversely affect the patient’s self-esteem. While complete excision of the lesion is curative, it may leave disfiguring scars. The treatment of VEN on the face is challenging.</div><div>We report a case of 28-year-old woman who presented with a wart-like lesion on the left side of her face which was accompanied by pruritus. Dermoscopy and histopathological examination were performed and the patient was diagnosed with VEN. She was treated with the carbon dioxide(CO2) laser and aminolevulinate photodynamic therapy (ALA-PDT). The carbon dioxide laser was applied to remove the hypertrophic lesion and enable the transdermal absorption of aminolevulinic acid. The first step was the topical application of a cream with 20 % ALA to the lesion, after which the area was sealed for three hours to block light before PDT treatment. Subsequent PDT treatment enhanced healing and reduced potential scarring. After 4 sessions of ALA-PDT, only slight elevation of the skin at the tumor site was observed, and the lesion could be concealed with makeup, thereby achieving a superior cosmetic effect. The patient experienced a significant reduction in psychological stress with marked alleviation of the pruritis. Therefore, we consider that ALA-PDT combined with CO2 laser is both safe and effective for treating facial verrucous epidermal nevus.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104785"},"PeriodicalIF":2.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining scar quality: A synergistic approach with micro-needling and photodynamic therapy using methylene blue as a photosensitizer: a randomized clinical trial","authors":"Mahshid Sabetghadam ,&nbsp;Behzad Imani ,&nbsp;Amir Derakhshan Far ,&nbsp;Fatemeh Shahbazi ,&nbsp;Zahra Farahani Nik","doi":"10.1016/j.pdpdt.2025.104787","DOIUrl":"10.1016/j.pdpdt.2025.104787","url":null,"abstract":"<div><h3>Background</h3><div>Hypertrophic and keloid scars are challenging to treat and can cause both aesthetic and functional problems. Traditional treatments such as laser therapy and corticosteroids have limited effectiveness and high recurrence rates. However, the emergence of photodynamic therapy (PDT) combined with micro-needling, especially when using methylene blue as a photosensitizer (PS) at different concentrations, offers a promising approach for scar treatment.</div></div><div><h3>Objective</h3><div>This study evaluates the effectiveness of combining PDT, micro-needling, and methylene blue at 1% and 0.1% concentrations to improve the quality of hypertrophic and keloid scars.</div></div><div><h3>Methods</h3><div>Novel Study Design: a randomized, double-blind clinical trial was conducted on 37 patients with 94 hypertrophic and keloid scars. Patients were divided into four groups based on scar type and methylene blue concentration. Each group underwent five treatment sessions, and scars were assessed using the Japan Scar Scale (JSS) and the Patient and Observer Scar Assessment Scale (POSAS).</div></div><div><h3>Results</h3><div>Significant Improvements: after five treatment sessions, we observed substantial improvements in various scar parameters. The Evaluation part of Japan Scar Scale (JSS) scores decreased from an average of 14.69 ± 2.81 at baseline to 4.69 ± 0.92 after six months, indicating a significant reduction in scar severity. The patient-observer scar assessment scale results show a notable improvement in Flexibility and thickness, with a 71% reduction in stiffness and a 69% reduction in pain. Overall, patient satisfaction increased by 60%, and visible improvements in pigmentation and vascularity were reported. The use of 1% methylene blue led to better outcomes than 0.1%, possibly due to enhanced light penetration and reactive oxygen species (ROS) generation. Importantly, no severe side effects were observed, and patient compliance remained high throughout the study.</div></div><div><h3>Conclusion</h3><div>Combining PDT and micro-needling using 1% methylene blue improves scar quality and prevents it from worsening, particularly for keloid scars. Further studies are recommended to confirm these findings and explore long-term effects.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104787"},"PeriodicalIF":2.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the efficacy of photodynamic therapy in treating cervical lesions and HPV infections and its influencing factors","authors":"Xueliang Hu ,&nbsp;Xuewang Guo ,&nbsp;Jing Sha ,&nbsp;Yu Dou ,&nbsp;Hui Ma ,&nbsp;Honglin Li ,&nbsp;Yanying Xu","doi":"10.1016/j.pdpdt.2025.104786","DOIUrl":"10.1016/j.pdpdt.2025.104786","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy of photodynamic therapy (PDT) in patients with human papillomavirus (HPV) infection and cervical lesions, meanwhile factors influencing the efficacy of PDT were analyzed.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed on 110 patients with HPV infection and cervical lesions. All patients underwent HPV genotyping, ThinPrep Cytology Test (TCT), and pathological examination, the changes before and after PDT treatment for 6 months were analyzed. In evaluating the therapeutic effect, if HPV is completely eliminated or cervical lesions return to normal, it was counted in the negative conversion rate; If HPV is partially eliminated or cervical lesions are downgraded but not return to normal, it was counted in the effective rate. Meanwhile, patients were grouped according to HPV vaccination history, menopausal status, transformation zone type and previous HPV infection history, and the therapeutic effects of anti-HPV and cervical lesion were compared among different groups.</div></div><div><h3>Results</h3><div>After PDT, the negative conversion rate of HPV was 45.45 % with an effective rate of 64.54 %; the negative conversion rate of TCT was 63.51 % with an effective rate of 68.91 %; and the negative conversion rate of pathology was 72.22 % with an effective rate of 79.62 %. The HPV negative conversion rate (78.57 % vs. 35.36 %) and TCT negative conversion rate (83.33 % vs. 57.14 %) in the vaccinated population were significantly higher than those in the unvaccinated population (<em>p</em> &lt; 0.05). The non-menopausal population showed significantly higher TCT negative conversion rate (72.00 % vs. 45.83 %) and effective rate (78.00 % vs. 45.83 %), as well as pathological negative conversion rate (85.36 % vs. 30.76 %) and effective rate (87.80 % vs. 46.15 %) compared with the menopausal population (<em>p</em> &lt; 0.05). Patients with type Ⅰ and Ⅱ transformation zone (TZ) show significantly better outcomes than those with TZ3 in anti-HPV treatment and cervical lesion management (<em>p</em> &lt; 0.05). Patients without a history of HPV infection had significantly higher TCT negative conversion rate (73.33 % vs. 35.89 %) and effective rate (73.33 % vs. 46.15 %) than those with a previous infection history (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>PDT shows good therapeutic effects in both HPV infection and cervical lesions. In addition, better therapeutic effects are observed in populations with a history of HPV vaccination, non-menopausal populations, populations without previous HPV infection, and those with type Ⅰ or Ⅱ cervical transformation zones.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104786"},"PeriodicalIF":2.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of corneal biomechanical parameters and corneal thickness measured by Corvis ST and AS-OCT in progressive keratoconus treated by accelerated corneal cross-linking","authors":"Luanying Wei,&nbsp;Tiantian Qi,&nbsp;Lei Luo,&nbsp;Qiang Shi,&nbsp;Shengjian Mi,&nbsp;Cheng Pei","doi":"10.1016/j.pdpdt.2025.104783","DOIUrl":"10.1016/j.pdpdt.2025.104783","url":null,"abstract":"<div><h3>Purpose</h3><div>To explore the characteristics of corneal biomechanical parameters and corneal thickness in different corneal regions in progressive keratoconus treated by accelerated “epithelium off” cross-linking (A-CXL) surgery.</div></div><div><h3>Methods</h3><div>This is a retrospective study and is self-controlled before and after surgery. A total of 39 eyes of 25 patients with progressive keratoconus were recruited and treated by A-CXL. The corneal biomechanical parameters and corneal thickness were recorded at baseline, 1-month, 3-month, and 6-month after surgery. Besides, analysis of correlations was applied to explore the association between these two features.</div></div><div><h3>Results</h3><div>Most of the biomechanical parameters, corneal thickness of different areas, as well as visual acuity, curvature and higher-order aberrations (HOAs), showed significant changes at 1 month and 3 months after surgery. Then gradually became stable and close to baseline values at 6 months postoperative. The epithelium became thicker earlier (after 1 month). The central and inferior areas of corneal stroma and the whole cornea were significantly thinnest at 3 months, other areas were thinnest at 1 month. Only several biomechanical parameters showed positive or negative correlations with corneal thickness, including the changes of them from baseline to different time after treatment.</div></div><div><h3>Conclusion</h3><div>The accelerated cross-linking not only has a significant effect, especially on the corneal central, inferotemporal, and inferonasal regions, which can prevent the progression of keratoconus. But also, can maintain the integrity of the epithelium, achieve corneal biomechanical recovery and improve visual acuity, curvature and HOAs in the short term at the same time.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104783"},"PeriodicalIF":2.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The photodynamic antimicrobial chemotherapy activities of azaBODIPY dyes and their gold nanoparticle conjugates","authors":"Temlandvo M. Magwaza,&nbsp;Nthabeleng Molupe,&nbsp;Yolande I. Openda,&nbsp;John Mack,&nbsp;Tebello Nyokong","doi":"10.1016/j.pdpdt.2025.104781","DOIUrl":"10.1016/j.pdpdt.2025.104781","url":null,"abstract":"<div><div>This synthesis and photophysicochemical properties of two 2,6-diiodinated azaBODIPY dyes with thiomethylphenyl groups at the distal positions and phenyl (<strong>1</strong>) and naphthyl (<strong>2</strong>) rings at the proximal positions are reported. The dyes were conjugated to gold nanoparticles (<strong>1</strong>-AuNPs and <strong>2</strong>-AuNPs) to enhance their aqueous solubility for biomedical applications. Iodination at the 2,6-positions resulted in an enhancement of singlet oxygen generation, with singlet oxygen quantum yield (Φ_∆) values of 0.82 and 0.55 obtained in DMSO for <strong>1</strong> and <strong>2</strong>, respectively. The photodynamic antimicrobial chemotherapy (PACT) activities of the dyes were tested with a Thorlabs M660L3 light-emitting diode (LED) against <em>Staphylococcus aureus</em> after incubation at 5 µM. Conjugation to gold nanoparticles was found to significantly enhance the PACT activities against <em>Staphylococcus aureus</em>. Log₁₀ reduction values of 8.94 were obtained for <strong>1</strong>-AuNPs after 30 min irradiation (3.0 J.cm⁻²) and <strong>2</strong>-AuNPs after 60 min (6.0 J.cm⁻²).</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104781"},"PeriodicalIF":2.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic efficacy of highly aspherical lenslets combined with low-concentration atropine: A retrospective study","authors":"Guorui Hu ,&nbsp;Zhixing Xu ,&nbsp;Zhengyang Tao ,&nbsp;Zongyue Lv ,&nbsp;Weishan Li ,&nbsp;Zefeng Kang ,&nbsp;Hongwei Deng","doi":"10.1016/j.pdpdt.2025.104779","DOIUrl":"10.1016/j.pdpdt.2025.104779","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to evaluate the efficacy of 0.01 % atropine (AT), highly aspherical lenslets (HAL), and their combination in controlling myopia progression in children and adolescents.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted involving 144 children and adolescents aged 8 to 15 years who visited Shenzhen Eye Hospital between 2022 and 2024. Patients were categorized by refractive status into SE &gt; -2.00 D (-2.00D &lt; spherical equivalent [SE] ≤ -0.25D) and SE ≤ -2.00 D (SE ≤ -2.00D in at least one eye) groups. The SE &gt; -2.00 D group was further divided into AT, HAL, and HAL+AT subgroups, while the SE ≤ -2.00 D group was divided into HAL and HAL+AT subgroups. Data collected included best-corrected visual acuity, cycloplegic SE, and axial length. The Shapiro-Wilk test was used to assess normality. Baseline differences were analyzed with parametric and non-parametric tests. Generalized estimating equations (GEE) were applied to evaluate longitudinal SE changes across groups, followed by post hoc comparisons.</div></div><div><h3>Results</h3><div>In both the SE &gt; -2.00 D and SE ≤ -2.00 D groups, the final GEE model identified statistically significant differences based on treatment group, time, baseline average spherical equivalent of both eyes (SE-mean), and age (<em>p</em> &lt; 0.05). In the SE &gt; -2.00 D group, the HAL+AT group significantly slowed myopia progression by 0.338D compared to the AT group. The HAL group also significantly slowed myopia progression by 0.235D compared to the AT group. In the SE ≤ -2.00 D group, after adjusting for potential covariates, the HAL+AT group significantly slowed myopia progression by 0.247D compared to the HAL group.</div></div><div><h3>Conclusion</h3><div>Over one year, combining HAL with 0.01 % atropine effectively controlled myopia progression in children and adolescents with varying refractive statuses.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104779"},"PeriodicalIF":2.6,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined surgical excision with open wound healing and photodynamic therapy for periocular basal cell carcinoma: A case report","authors":"Teng Song ,&nbsp;Baixin Li ,&nbsp;Shuang Zhao ,&nbsp;Wei Wang","doi":"10.1016/j.pdpdt.2025.104778","DOIUrl":"10.1016/j.pdpdt.2025.104778","url":null,"abstract":"<div><div>This study evaluated a combined approach of surgical excision with open wound healing and photodynamic therapy (PDT) for periocular basal cell carcinoma (BCC) in a 72-year-old male patient, whose lesion involved a high-risk anatomical location due to direct proximity to ocular structures. The patient presented with a 7-year history of progressive periocular BCC involving the medial canthus and nasal root. Given the lesion’s proximity to ocular structures, a staged protocol was implemented with three preoperative PDT sessions administered weekly to reduce tumor burden. Gross tumor resection with 1–2 mm margins was then performed, leaving the wound to heal by secondary intention. Immediate postoperative PDT was followed by a second PDT cycle of three weekly sessions. Preoperative PDT achieved significant tumor regression. Surgical excision proceeded with minimal tissue loss. Subsequent histopathology of the specimen revealed positive peripheral margins, retrospectively validating the necessity of the PDT for treating residual disease. No recurrence was observed over a 5-year follow-up, and the healed scar was flat, pliable, and caused no functional or significant cosmetic concern to the patient. The combined approach preserved anatomical integrity and function while avoiding extensive reconstructive surgery risks. It offers a viable alternative to radical excision, balancing oncologic outcomes with functional and cosmetic preservation. Further studies are warranted to optimize protocols for similar anatomically challenging cases.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104778"},"PeriodicalIF":2.6,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of subjective efficacy of 5-aminolevulinic acid photodynamic therapy in the treatment of refractory vulvar lichen sclerosus","authors":"Guiqin Chen ,&nbsp;Yicheng Li ,&nbsp;Jingyi Mu ,&nbsp;Zhenzhen Lu ,&nbsp;Lei Cao ,&nbsp;Xin Cheng ,&nbsp;Yue Wang","doi":"10.1016/j.pdpdt.2025.104768","DOIUrl":"10.1016/j.pdpdt.2025.104768","url":null,"abstract":"<div><h3>Objective</h3><div>This study evaluated the therapeutic effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in refractory Vulvar lichen sclerosus (VLS) patients. <strong><em>Methods</em></strong><em>:</em> This prospective study enrolled a total of 60 patients with refractory VLS. These patients received 6 sessions of ALA-PDT treatment. Follow-ups were conducted at 3, 6 and 12 months after treatment to evaluate the improvement of patients' subjective symptom and objective clinical signs. In addition, the Dermatology Life Quality Index (DLQI) was used to assess the quality of life (QoL) of patients after treatment.</div></div><div><h3>Results</h3><div>Significant reductions were observed in both itching and burning pain scores post-treatment (p &lt; 0.05). Objective clinical signs also demonstrated marked improvement (p &lt; 0.01). At 12 months after treatment, 53 of 60 patients (88.33%) achieved clinically significant response (defined as ≥50% reduction in symptom scores). The DLQI score decreased from 20 points before treatment to 4, 2, and 3, indicating enhanced QoL. Most adverse reactions were mild and resolved with supportive care.</div></div><div><h3>Conclusion</h3><div>ALA-PDT represents a promising therapeutic alternative for refractory VLS, offering sustained symptom relief and objective clinical improvement with a favorable safety profile.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104768"},"PeriodicalIF":2.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal curvature in myopia: correlation with ocular physiological parameters","authors":"Siyu Yang,&nbsp;Ruibing Sun,&nbsp;Nan Xu,&nbsp;Lijiao Lu,&nbsp;Danyang Wang,&nbsp;Mingzhe Cao","doi":"10.1016/j.pdpdt.2025.104771","DOIUrl":"10.1016/j.pdpdt.2025.104771","url":null,"abstract":"<div><h3>Purpose</h3><div>Investigate the correlation of retinal curvature (RC) with ocular physiological parameters in myopic eyes.</div></div><div><h3>Method</h3><div>Clinical data from 332 patients (447 myopic eyes) were retrospectively analyzed. Eyes were classified into low myopia (LM), moderate myopia (MM), and high myopia (HM) groups based on spherical equivalent (SE) and axial length (AL). Ultra-widefield swept­source optical coherence tomography (UWF-SS-OCT) was used to acquire 24 × 20 mm OCT scans. Bruch’s membrane segmentation and AL-based correction produced a 3D retinal model. RC maps derived top curvature values (RC-MAX, RC-MID, RC-MIN) averaged as RC-AVE. Angiography quantified retinal vessel density (RVD), subfoveal choroidal thickness (SFCT), and choroidal parameters (CVI: choroidal vessel index; CSV/a: choroidal stromal volume per unit area; CVV/a: choroidal vascular volume per unit area) in macular and optic disc areas.</div></div><div><h3>Results</h3><div>RC-AVE decreased with myopia severity: LM: 1.02 (0.89, 1.14) × 10⁻²mm⁻², MM: 0.93 (0.83, 1.12) × 10⁻²mm⁻², HM: 0.76 (0.67, 0.90) × 10⁻²mm⁻². RC exhibited a significant negative correlation with AL (β = - 3.15, <em>p</em> &lt; 0.001) and significant positive correlations with SE (β = 5.34, <em>p</em> &lt; 0.001) and SFCT (β = 56.61, <em>p</em> = 0.001). In the macular region, RC positively correlated with choroidal vascular parameters CSV/a and CVV/a (β = 30.62, <em>p</em> = 0.005; β = 18.67, <em>p</em> = 0.002). In the optic disc region, RC showed significant positive associations with CVI, CSV/a, and CVV/a (β = 3.66, <em>p</em> &lt; 0.001; β = 49.56, <em>p</em> &lt; 0.001; β = 38.04, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>RC can quantitatively characterize retinal shape and the morphological changes induced by myopia. Significantly reduced RC in high myopia, with RC exhibiting negative correlations with AL and positive correlations with SE, SFCT, and vascular parameters.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104771"},"PeriodicalIF":2.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of macular microvascular changes in gestational diabetes mellitus","authors":"Mukaddes Damla Ciftci ,&nbsp;Filiz Afrashi ,&nbsp;Cumali Degirmenci ,&nbsp;Didem Gul Saritas ,&nbsp;Fuat Akercan","doi":"10.1016/j.pdpdt.2025.104770","DOIUrl":"10.1016/j.pdpdt.2025.104770","url":null,"abstract":"<div><h3>Background</h3><div>To evaluate retinal microvascular changes in GDM patients in the prepartum and postpartum periods with optical coherence tomography angiography (OCTA).</div></div><div><h3>Methods</h3><div>Forty-nine GDM patients (Group 1) and 39 healthy pregnant women (Group 2) were included in this study. Vascular density, foveal avascular zone (FAZ) area, and flow area were measured by OCTA. Twenty-four volunteers from Group 1 and 11 volunteers from Group 2 were re-evaluated after the 6th postpartum week.</div></div><div><h3>Results</h3><div>The mean age was 32.02±4.65 (23–42) in Group 1 and 30±5.66 (18–42) in Group 2. The average gestational week was 32.08±2.92 (23–38) and 31.31±3.51 (24–37) weeks in Group 1 and 2, respectively. Deep capillary plexus vascular density (DCP-VD) was found to be significantly lower in the GDM group (58.38±5.5 % and 60.52±3.75 %; <em>p</em> = 0.01). In the postpartum period, significant increase was observed in both superficial capillary plexus vascular density (SCP-VD) and DCP-VD in only the Group 1 when compared to the prepartum period, overtime (54.53±1.93 % and 53.04±2.83 %; 60.17±4.28 % and 58.38±5.5 %; <em>p</em> &lt; 0.001 and <em>p</em> = 0.018, respectively). When the correlation between the data obtained from OCTA and HbA1c values of a total of 88 volunteers in Group 1 and Group 2 was evaluated, a negative correlation was detected between choriocapillaris flow measurements and HbA1c values in the prepartum period (<em>p</em> = 0.05, ϱ=-0.22).</div></div><div><h3>Conclusion</h3><div>DCP-VD in GDM patients was lower than healthy pregnant women. It was shown that vascular density increases in both deep and superficial capillary plexus with the establishment of postpartum normoglycemia.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104770"},"PeriodicalIF":2.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}