Analysis of the efficacy of photodynamic therapy in treating cervical lesions and HPV infections and its influencing factors

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-08-28 DOI:10.1016/j.pdpdt.2025.104786

Xueliang Hu , Xuewang Guo , Jing Sha , Yu Dou , Hui Ma , Honglin Li , Yanying Xu

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引用次数: 0

Abstract

Objective

To evaluate the efficacy of photodynamic therapy (PDT) in patients with human papillomavirus (HPV) infection and cervical lesions, meanwhile factors influencing the efficacy of PDT were analyzed.

Methods

A retrospective analysis was performed on 110 patients with HPV infection and cervical lesions. All patients underwent HPV genotyping, ThinPrep Cytology Test (TCT), and pathological examination, the changes before and after PDT treatment for 6 months were analyzed. In evaluating the therapeutic effect, if HPV is completely eliminated or cervical lesions return to normal, it was counted in the negative conversion rate; If HPV is partially eliminated or cervical lesions are downgraded but not return to normal, it was counted in the effective rate. Meanwhile, patients were grouped according to HPV vaccination history, menopausal status, transformation zone type and previous HPV infection history, and the therapeutic effects of anti-HPV and cervical lesion were compared among different groups.

Results

After PDT, the negative conversion rate of HPV was 45.45 % with an effective rate of 64.54 %; the negative conversion rate of TCT was 63.51 % with an effective rate of 68.91 %; and the negative conversion rate of pathology was 72.22 % with an effective rate of 79.62 %. The HPV negative conversion rate (78.57 % vs. 35.36 %) and TCT negative conversion rate (83.33 % vs. 57.14 %) in the vaccinated population were significantly higher than those in the unvaccinated population (p < 0.05). The non-menopausal population showed significantly higher TCT negative conversion rate (72.00 % vs. 45.83 %) and effective rate (78.00 % vs. 45.83 %), as well as pathological negative conversion rate (85.36 % vs. 30.76 %) and effective rate (87.80 % vs. 46.15 %) compared with the menopausal population (p < 0.05). Patients with type Ⅰ and Ⅱ transformation zone (TZ) show significantly better outcomes than those with TZ3 in anti-HPV treatment and cervical lesion management (p < 0.05). Patients without a history of HPV infection had significantly higher TCT negative conversion rate (73.33 % vs. 35.89 %) and effective rate (73.33 % vs. 46.15 %) than those with a previous infection history (p < 0.05).

Conclusion

PDT shows good therapeutic effects in both HPV infection and cervical lesions. In addition, better therapeutic effects are observed in populations with a history of HPV vaccination, non-menopausal populations, populations without previous HPV infection, and those with type Ⅰ or Ⅱ cervical transformation zones.

查看原文本刊更多论文

光动力疗法治疗宫颈病变及HPV感染的疗效及影响因素分析。

目的：评价光动力疗法（PDT）治疗人乳头瘤病毒（HPV）感染及宫颈病变的疗效，并分析影响PDT疗效的因素。方法：对110例HPV感染合并宫颈病变患者进行回顾性分析。所有患者均行HPV基因分型、TCT及病理检查，分析PDT治疗前后6个月的变化。在评价治疗效果时，若HPV完全消除或宫颈病变恢复正常，则计入阴性转换率；如果HPV被部分消除或宫颈病变降级但未恢复正常，则计算在有效率中。同时，根据HPV疫苗接种史、绝经状态、转化带类型及既往HPV感染史对患者进行分组，比较各组抗HPV及宫颈病变的治疗效果。结果：PDT术后HPV阴性转化率为45.45%，有效率为64.54%；TCT负转换率为63.51%，有效率为68.91%；病理阴性转换率为72.22%，有效率为79.62%。接种人群HPV阴性转阴率（78.57% vs. 35.36%）和TCT阴性转阴率（83.33% vs. 57.14%）均显著高于未接种人群(p结论：PDT对HPV感染和宫颈病变均有良好的治疗效果。此外，在有HPV疫苗接种史的人群、未绝经人群、既往未感染HPV的人群以及Ⅰ型或Ⅱ型宫颈转化带的人群中观察到更好的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.