Photodiagnosis and Photodynamic Therapy最新文献

{"title":"A comparative analysis of lamina Cribrosa curvature index values in different stages of diabetic retinopathy","authors":"Mübeccel Bulut ,&nbsp;Ali H Reyhan","doi":"10.1016/j.pdpdt.2025.104769","DOIUrl":"10.1016/j.pdpdt.2025.104769","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare lamina cribrosa structural parameters for diabetic retinopathy and evaluate the potential use of the lamina cribrosa curvature index (LCCI) as a biomarker for progression.</div></div><div><h3>Methods</h3><div>All participants underwent comprehensive ophthalmic examinations and optical coherence tomography (OCT) imaging of the optic nerve head. The following lamina cribrosa parameters were measured from high-resolution B-scan images; LCCI, lamina cribrosa curve depth (LCCD), anterior lamina cribrosa depth (ALCD), and lamina cribrosa thickness (LCT). The LCCI was calculated as the ratio of LCCD to Bruch’s membrane opening (BMO) width, multiplied by 100, and was used to assess posterior bowing of the lamina cribrosa.</div></div><div><h3>Results</h3><div>One hundred sixty eyes of 80 participants (mean age 57.3 ± 9.9 years) were analyzed. LCCI values were significantly lower in the proliferative diabetic retinopathy (PDR) group (7.34 ± 1.85 %) compared to the diabetic patients without retinopathy (9.91 ± 3.47 %) and the control (10.13 ± 3.26 %) group. LCCD was also lower in the PDR group (122.46 ± 27.51 µm), than in the diabetic patients without retinopathy (165.8 ± 55.19 µm) and the controls (161.94 ± 46.12 µm). ALCD was lowest in the PDR group (301.7 ± 37.01 µm) and highest in the controls (365.35 ± 57.78 µm). With the exception of BMO, neither HbA1c nor duration of diabetes exhibited significant correlations with any lamina cribrosa parameters.</div></div><div><h3>Conclusion</h3><div>Despite distinct pathophysiological patterns compared to other optic neuropathies, the LCCI reveals significant progressive changes that may serve as a valuable biomarker for disease progression in diabetic retinopathy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104769"},"PeriodicalIF":2.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of manual, image-guided, and femtosecond laser-assisted marking techniques for toric intraocular lens alignment","authors":"Fei Yang ,&nbsp;Yang Yu ,&nbsp;Xijuan Wang ,&nbsp;Jiayin Qin ,&nbsp;Xiaochun Li ,&nbsp;Yan Zhang ,&nbsp;Lisha Huang ,&nbsp;Xue Yang ,&nbsp;Yaqian Niu ,&nbsp;Mingwu Li ,&nbsp;Guangfeng Liu","doi":"10.1016/j.pdpdt.2025.104772","DOIUrl":"10.1016/j.pdpdt.2025.104772","url":null,"abstract":"<div><h3>Background</h3><div>To compare the visual outcomes and the accuracy of three axial marking techniques for toric intraocular lenses (IOLs): manual marking, the CALLISTO eye image-guided system and femtosecond laser-assisted capsulotomy marking.</div></div><div><h3>Methods</h3><div>A total of 105 eyes of 105 patients were enrolled in this retrospective comparative study. According to different axial marking methods, patients were assigned to the manual marking group (MM group), CALLISTO Eye image-guided system group (CE group) and femtosecond laser-assisted capsulotomy marking group (CM group). Uncorrected distant visual acuity (UCDVA), best corrected distant visual acuity, residual astigmatism, toric IOL misalignment, and modulation transfer function were measured and compared preoperatively and one month and three months postoperatively.</div></div><div><h3>Results</h3><div>Postoperative UCDVA and residual astigmatism were significantly lower in the CM group than in the MM group and CE group both at one month and three months postoperatively. IOL misalignment in the CM group was significantly less than that in the other two groups, and the CE group also performed better than the MM group. The AR values in the CE group and CM group were significantly higher than those in the MM group. Further correlation analysis found that postoperative UCDVA was positively correlated with residual astigmatism and IOL misalignment and negatively correlated with AR value. Postoperative residual astigmatism was positively correlated with IOL misalignment and negatively correlated with AR value.</div></div><div><h3>Conclusion</h3><div>Femtosecond laser-assisted capsulotomy marking provided the best visual outcomes and accurate alignment for toric IOLs. The CALLISTO eye image-guided marking performed moderately but slightly better than manual marking.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104772"},"PeriodicalIF":2.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors for postoperative macular microcirculation remodeling in idiopathic full–thickness macular hole","authors":"Jingling Zou ,&nbsp;Nan Wang ,&nbsp;Feng Zhang ,&nbsp;Haiyan Lian ,&nbsp;Jun Zeng ,&nbsp;Yan Yang","doi":"10.1016/j.pdpdt.2025.104767","DOIUrl":"10.1016/j.pdpdt.2025.104767","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the features of the macular microcirculation using optical coherence tomography angiography (OCTA) in surgically closed idiopathic full–thickness macular hole (IFTMH) and the correlated independent prognostic factors for postoperative macular microcirculation remodeling.</div></div><div><h3>Methods</h3><div>Twenty–seven eyes of 27 patients after successful IFTMH surgery that were followed for 6 months and 27 eyes of 27 age– and gender–matched healthy subjects were included. Patients with IFTMH and healthy subjects were examined using OCTA. Macular vessel density (VD), foveal avascular zone (FAZ) area of superficial capillary plexus (SCP), and flow area of outer retina and choroid were analyzed. Best–corrected visual acuity (BCVA) was evaluated before and 6 months after the surgery.</div></div><div><h3>Results</h3><div>The BCVA improved in eyes with IFTMH after the surgery (<em>p</em> &lt; 0.001). Postoperative VD was significantly lower in eyes with IFHMH compared with the normal control eyes (<em>p</em> &lt; 0.001). The mean flow area of the outer retina in eyes that underwent IFTMH surgery was significantly larger than normal control eyes (<em>p</em> &lt; 0.05), while the mean flow area of choroid capillary in postoperative IFTMH was significantly lower (<em>p</em> &lt; 0.01). Foveal VD was negatively correlated with both minimal and basal diameters (r = −0.473, <em>p</em> &lt; 0.05; r = −0.504, <em>p</em> &lt; 0.01). FAZ area was significantly positively correlated with both minimal and basal diameters (r = 0.635, <em>p</em> &lt; 0.001; r = 0.606, <em>p</em> &lt; 0.01). Additionally, the age of IFTMH was negatively correlated with the postoperative whole VD (r = –0.440, <em>p</em> &lt; 0.05) and positively correlated with the FAZ area (r = 0.382, <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Macular capillary plexuses observed by OCTA in eyes after IFTMH surgery had different characteristics compared to normal control eyes. Preoperative IFTMH characteristics can serve as prognostic factors for postoperative macular microcirculation remodeling.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104767"},"PeriodicalIF":2.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of photodynamic therapy for cervical intraepithelial neoplasia grade 3: a retrospective study","authors":"Huihui Cai ,&nbsp;Yu Liu ,&nbsp;Yanci Che ,&nbsp;Yanhui Lou ,&nbsp;Huaqin Sun ,&nbsp;Tingting Ma ,&nbsp;Yankui Wang","doi":"10.1016/j.pdpdt.2025.104773","DOIUrl":"10.1016/j.pdpdt.2025.104773","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to evaluate the histologic response rate of high-grade squamous intraepithelial lesion (HSIL), also referred to as cervical intraepithelial neoplasia 3 (CIN 3), following treatment with 5-aminolevulinic acid photodynamic therapy (ALA-PDT).</div></div><div><h3>Method</h3><div>A retrospective analysis was conducted on 49 patients diagnosed with CIN 3 and treated with ALA-PDT between March 2022 and December 2024. Patients received either ALA-PDT alone or in combination with the Loop Electrosurgical Excision Procedure (LEEP) or CO₂ laser therapy. Clinical outcomes, including human papillomavirus (HPV) status, cytology, and histology, were assessed over a 12-month follow-up period.</div></div><div><h3>Results</h3><div>Among the 44 patients with complete follow-up, the total response rate was 85.19% (23/27) for ALA-PDT alone and 88.24% (15/17) for combination therapy, yielding an overall response rate of 86.36% (38/44). The double-negative rate (negative for both HPV and histopathology) was 100%. When stratified by age group, pathology-negative outcomes—considered effective treatment responses—were observed in 100% of patients younger than 20, 80% of those aged 21–30, 93.7% in the 31–40 age group, and 100% in patients over 40. The total effective rates across different cervical transformation zones (TZ) were 75% (18/24) for TZ1, 100% (12/12) for TZ2, and 100% (8/8) for TZ3. Negative HPV conversion rates were 82.35% (28/34) in the HPV16/18-positive group, 80% (8/10) in the non-HPV16/18 group, and 73.33% (11/15) in the multiple high-risk HPV group.</div></div><div><h3>Conclusion</h3><div>ALA-PDT demonstrates favorable efficacy and stability in patients with HSIL/CIN 3, offering clinicians an additional option for managing these cervical lesions.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104773"},"PeriodicalIF":2.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approach to optic disc swelling with macular subretinal fluid and choroidal folds: a narrative review","authors":"Kelly Wai Lam Cheung ,&nbsp;Sunny Chi Lik Au","doi":"10.1016/j.pdpdt.2025.104774","DOIUrl":"10.1016/j.pdpdt.2025.104774","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104774"},"PeriodicalIF":2.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Differential correlations of refractive error, axial length, and axial length-to-corneal curvature ratio with anterior segment biometrics in myopic refractive surgery candidates” [Photodiagnosis and Photodynamic Therapy, volume 50, December 2024, page 2]","authors":"Jian Zhang ,&nbsp;Youlin Zhu ,&nbsp;Ping Yuan ,&nbsp;Xiaojuan Dong ,&nbsp;Manyun Xie ,&nbsp;Zongrui Ma ,&nbsp;Rong Tian","doi":"10.1016/j.pdpdt.2025.104742","DOIUrl":"10.1016/j.pdpdt.2025.104742","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104742"},"PeriodicalIF":2.6,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute macular neuroretinopathy in COVID-19 patients: Short-term prospective follow-up observation","authors":"Ting Mei ,&nbsp;Xuhui Chen ,&nbsp;Qi Zhang ,&nbsp;Jin Gong","doi":"10.1016/j.pdpdt.2025.104752","DOIUrl":"10.1016/j.pdpdt.2025.104752","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aims to characterize the multimodal imaging findings and clinical features of acute macular neuroretinopathy (AMN) in a series of coronavirus disease 2019 (COVID-19) patients from China.</div></div><div><h3>Methods</h3><div>In this observational study, a total of 18 patients (30 eyes) with post-COVID-19 infection presenting as AMN were enrolled between December 2022 and May 2024 and underwent a minimum of 12 months of ophthalmic follow-up. Multimodal imaging features following severe acute respiratory syndrome coronavirus 2 infection were evaluated by infrared (IR) reflectance imaging, ultrawide-field scanning laser ophthalmoscopy, spectral-domain optical coherence tomography (SD-OCT), optical coherence tomography angiography, visual field testing, and fundus fluorescein angiography.</div></div><div><h3>Results</h3><div>Scotomas were present in all 18 patients (30 eyes) at the initial visit. IR reflectance imaging revealed localized areas of hyporeflectivity in the macular region in 5 patients (8 eyes). SD-OCT scans demonstrated hyper-reflective changes within the photoreceptor layer and disruption of its normal laminar architecture in all 18 patients (30 eyes). All cases in this series exhibited signs of classic maculopathy. Notably, these abnormalities persisted for at least 12 months in all affected eyes.</div></div><div><h3>Conclusion</h3><div>These data suggest that AMN is a significant ocular manifestation in patients with COVID-19, characterized by persistent scotomas lasting at least 12 months.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104752"},"PeriodicalIF":2.6,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Clinical and pre-clinical advances in the PDT/PTT strategy for diagnosis and treatment of Cancer” [Photodiagnosis and Photodynamic Therapy. Volume 50 (2024), 104387]","authors":"Coralía Fabiola Cuadrado ,&nbsp;Karina J. Lagos ,&nbsp;Mirian Denise Stringasci ,&nbsp;Vanderlei Salvador Bagnato ,&nbsp;María Paulina Romero","doi":"10.1016/j.pdpdt.2025.104741","DOIUrl":"10.1016/j.pdpdt.2025.104741","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104741"},"PeriodicalIF":2.6,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative analysis of microvasculature in macular and optic disc regions in keratoconus patients: A systematic review and meta-analysis","authors":"Ling Ling ,&nbsp;Wei Yan ,&nbsp;Yi Zhao ,&nbsp;Kaichao Xia ,&nbsp;Yiqiao Xing ,&nbsp;Yang Yang ,&nbsp;Wei Wan ,&nbsp;Kaibao Ji","doi":"10.1016/j.pdpdt.2025.104766","DOIUrl":"10.1016/j.pdpdt.2025.104766","url":null,"abstract":"<div><h3>Background</h3><div>Studies have utilized optical coherence tomography angiography (OCTA) to assess vessel density in the macular and optic disc regions among patients with keratoconus (KC); however, the findings have been incongruent. This study aimed to systematically investigate the retinal macular and optic disc microvascular characteristics in patients with KC compared to healthy controls using OCTA.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was performed across multiple electronic databases, including PubMed, Embase, Web of Science, and the Cochrane Library, up to April 2025. The vessel density metrics of the macular and optic disc regions were extracted and analyzed for both keratoconus patients and healthy controls. Mean differences (MDs) with 95 % confidence intervals were calculated to compare continuous variables. Statistical analyses were conducted using Review Manager Version 5.4.1 software.</div></div><div><h3>Results</h3><div>A total of six studies were included in our analysis. The results demonstrated that the macular whole enface superficial vessel density was significantly lower in the keratoconus (KC) group compared to the control group (MD = -4.45, <em>P</em> &lt; 0.00001). Additionally, there were significant differences in foveal superficial and deep vessel densities between the two groups (MD = -3.27, <em>P</em> = 0.001; MD = -3.58, <em>P</em> = 0.0003, respectively). The parafoveal superficial vessel density in the KC group was markedly reduced compared to that of the controls (MD = -6.21, <em>P</em> = 0.0004). For perifoveal vessel density, patients with KC exhibited significantly decreased vessel density in both the superficial and deep capillary plexuses compared to the control group (MD = -5.12, <em>P</em> &lt; 0.00001; MD = -9.16, <em>P</em> = 0.01, respectively). Furthermore, the radial peripapillary capillary (RPC) whole image vessel density was substantially lower in KC eyes than in the control group (MD = -0.89, <em>P</em> = 0.02).</div></div><div><h3>Conclusion</h3><div>The current meta-analysis demonstrated that the vascular density in the macular and optic nerve head regions was reduced in patients with KC, suggesting that retinal microvasculature could serve as a potential biomarker for aiding in the diagnosis of KC.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104766"},"PeriodicalIF":2.6,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Galactose-modified zinc phthalocyanines for colon cancer photodynamic therapy","authors":"Weiying Ge ,&nbsp;Yuetong Liu ,&nbsp;Haiying Ji ,&nbsp;Haoyan Chen ,&nbsp;Tianjun Liu ,&nbsp;Ge Hong ,&nbsp;Zhanjuan Zhao","doi":"10.1016/j.pdpdt.2025.104765","DOIUrl":"10.1016/j.pdpdt.2025.104765","url":null,"abstract":"<div><div>In a previous research, galactose groups were introduced into the structure of zinc phthalocyanine (ZnPc) to enhance water solubility and tumor-targeting ability for <em>in vivo</em> fluorescence imaging. Galactose-modified ZnPcs (T1-4) showed great potential as near-infrared optical probes in the diagnose of cancer. However, it had not yet been determined whether they could also serve as antitumor candidates for photodynamic therapy (PDT). In this study, the cellular uptake, photodynamic activity and anti-tumor mechanisms of T1-4 against colon cancer <em>in vitro</em> were investigated. The results showed that the cellular uptake of T1-4 in colon cancer and fibroblast cell lines was both concentration- and time-dependent, and ZnPc with one galactose group (T1) exhibited the optimal cellular uptake. Under 650 nm laser irradiation for 20 min (6 J/cm²), T1-3 (1.25-40 µM) displayed significant cytotoxicity against colon cancer cells. T1 mainly localized in lysosomes of CT-26, and T1-PDT destroyed the membrane structure of cells. The anti-tumor mechanism of T1-PDT in CT-26 cells was mainly related to the induction of autophagy, which was accompanied by upregulation of the autophagy biomarkers beclin-1 and LC3-II, and meanwhile downregulation of the autophagy-related protein P62. These findings reinforced the potential of galactose-modified ZnPcs (T1-4) as photosensitive agents for colon cancer PDT and their anti-tumor mechanism was related to the activation of autophagy in colon cancer cells.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104765"},"PeriodicalIF":2.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}