Photodiagnosis and Photodynamic Therapy最新文献

{"title":"The clinical value of reflectance confocal microscopy in monitoring treatment of actinic keratosis: A systematic review","authors":"Jinrui Zhang,&nbsp;Haolong Ran,&nbsp;Yongyao Zhao,&nbsp;Xiyu Liang,&nbsp;Zhiqian Gu,&nbsp;Yanning Xue","doi":"10.1016/j.pdpdt.2025.104539","DOIUrl":"10.1016/j.pdpdt.2025.104539","url":null,"abstract":"<div><h3>Background</h3><div>Actinic keratosis (AK) is a precancerous skin lesion that can progress to squamous cell carcinoma (SCC). Early diagnosis and effective treatment are crucial, but current treatment evaluation methods lack consistency. Reflectance confocal microscopy (RCM) has emerged as a promising non-invasive tool for monitoring treatment outcomes in AK, but the absence of standardized evaluation protocols limits its clinical applicability.</div></div><div><h3>Objective</h3><div>This study aims to establish standardized RCM imaging features for evaluating treatment responses in AK, thereby enhancing the consistency and clinical utility of RCM in treatment monitoring.</div></div><div><h3>Methods</h3><div>A systematic review was conducted following the PRISMA 2020 guidelines. Studies that evaluated the treatment of AK using RCM were included. A comprehensive literature search was performed across MEDLINE, Embase, and the Cochrane Library up to October 2024. Data on study design, treatment modalities, RCM imaging features, and scoring systems were extracted. A meta-analysis was not performed due to heterogeneity in study designs and outcome measures.</div></div><div><h3>Conclusion</h3><div>This review identifies key RCM imaging features of AK, including keratinocyte atypia and architectural disarray, and highlights the lack of a standardized scoring system for evaluating treatment outcomes. The findings underscore the need for a universally accepted protocol to improve the consistency and reliability of RCM in clinical practice. Standardization of RCM evaluation will enhance its utility in both clinical monitoring and future research on AK treatment.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104539"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of foveal microstructural reconstruction after idiopathic macular hole surgery","authors":"Mengqi An ,&nbsp;Xiang Zhang ,&nbsp;Zetong Nie,&nbsp;Naxin Duan,&nbsp;Chang Liu,&nbsp;Xiaorong Li,&nbsp;Wenbo Li,&nbsp;Bojie Hu","doi":"10.1016/j.pdpdt.2025.104541","DOIUrl":"10.1016/j.pdpdt.2025.104541","url":null,"abstract":"<div><h3>Purpose</h3><div>To identify prediction models and risk factors for anatomical microstructural reconstruction after surgery for idiopathic macular holes (IMHs).</div></div><div><h3>Methods</h3><div>This retrospective study involved 74 patients (77 eyes) who underwent successful closure after IMH surgery. The conventional MH indicators, macular hole occupancy index (MHOI) and internal limiting membrane (ILM) peeling index were calculated. Binary logistic regression analysis was used to identify prognostic factors and establish predictive models.</div></div><div><h3>Results</h3><div>The early postoperative anatomy of the inner segment/outer segment (IS/OS) showed a significant correlation with the MHOI, macular hole index (MHI), and traction hole index (THI) (<em>P</em> = 0.018, <em>P</em> = 0.047, <em>P</em> = 0.002, at-1-month; <em>P</em> = 0.008, <em>P</em> = 0.014, <em>P</em> = 0.005, at-3-months). Poorer preoperative best-corrected visual acuity (BCVA) (β = 2.954, <em>P</em> = 0.002) and larger inferior ILM peeling index (IIPI) (β = 7.446, <em>P</em> = 0.006) predicted poorer IS/OS prognosis. The early postoperative continuity of external limiting membrane (ELM) was significantly associated with the MHOI(<em>P</em> = 0.005), diameter hole index (DHI) (<em>P</em> = 0.031), MHI (<em>P</em> = 0.004), and THI (<em>P</em> &lt; 0.001). Larger IIPI (β = 8.490, <em>P</em> = 0.004 at-1-month) and poorer preoperative BCVA (β = 3.665, <em>P</em> = 0.001, at-1-month; β = 4.342, <em>P</em> = 0.002, at-3-months) were independent risk factors. Outer nuclear layer (ONL) disruption was significantly predicated by poorer preoperative BCVA (β = -2.781, <em>P</em> = 0.019) and larger IIPI (β = -5.653, <em>P</em> = 0.061). IS/OS and ELM integrity correlated with early postoperative BCVA, whereas the ONL showed sustained significance over 6 months.</div></div><div><h3>Conclusion</h3><div>MHOI, MHI, and THI influenced the repair of the IS/OS, ELM, and ONL in the short-term. Preoperative BCVA and IIPI were crucial for long-term prognosis of foveal microstructure. Foveal microstructure integrity is closely related to postoperative visual function recovery.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104541"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fundus changes in healthy adults after high altitude exposure","authors":"Jiaxin Li ,&nbsp;Yunzhu Kong ,&nbsp;Peiyu Wang ,&nbsp;Chen Chen,&nbsp;Juping Liu,&nbsp;Xiaorong Li,&nbsp;Yan Shao","doi":"10.1016/j.pdpdt.2025.104542","DOIUrl":"10.1016/j.pdpdt.2025.104542","url":null,"abstract":"<div><h3>Background</h3><div>To quantify the changes of long-term high altitude (HA) exposure of fundus in healthy adults. The aim is to provide a reference for the prevention and treatment of high altitude ophthalmopathy.</div></div><div><h3>Methods</h3><div>30 eyes of 15 healthy participants exposed to high altitude were recruited in this study. Swept-source optical coherence tomography/Swept-source optical coherence tomography angiography (SS-OCT/SS-OCTA) was used to analyze fundus changes in participants before and after plateau exposure. Fundus metrics included best corrected visual acuity (BCVA), the thickness of the retina (ReT), Inner ReT, Outer ReT, nerve fiber layer thickness (RNFLT), and ganglion cell internal plexiform layer thickness (GCIPLT), vascular density (VD), the size of the perfusion area (PA), choroidal vessel volume (CVV), and choroidal vascularity index (CVI) in all quadrants of the macula. All metrics were analyzed by generalized estimating equations (GEE).</div></div><div><h3>Results</h3><div>Compared with baseline data, all participants who worked at high altitude for more than one year showed no change in visual acuity (<em>P</em> &gt; 0.05) and a decreased in ReT, Outer ReT, GCIPLT and VD in all quadrants (<em>P</em> &gt; 0.05). In addition, Inner ReT and RNFLT show an upward trend (<em>P</em> &gt; 0.05). PA was significantly increased in the overall retina, Inner retina, superficial capillary plexus (SCP), and middle capillary plexus (ICP) (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The systemic adaptive changes due to high altitude exposure may cause varying degrees of structural and functional changes in the fundus. The current findings require large-scale longitudinal studies to obtain more definitive data on this topic.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104542"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large primary macular holes treated with internal limiting membrane peeling: A literature review","authors":"Wai Yan Lam ,&nbsp;Sunny Chi Lik Au","doi":"10.1016/j.pdpdt.2025.104540","DOIUrl":"10.1016/j.pdpdt.2025.104540","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104540"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro efficacy of photodynamic therapy with toluidine blue for decontamination of resorbable membranes inoculated with Streptococcus mutans","authors":"Ardavan Etemadi ,&nbsp;Sepideh Zonoozi ,&nbsp;Maryam Shad ,&nbsp;Nasim Chiniforush","doi":"10.1016/j.pdpdt.2025.104537","DOIUrl":"10.1016/j.pdpdt.2025.104537","url":null,"abstract":"<div><h3>Objectives</h3><div>This study assessed the efficacy of antimicrobial photodynamic therapy (aPDT) with toluidine blue (TB) for decontamination of resorbable membranes inoculated with <em>Streptococcus mutans (S. mutans).</em></div></div><div><h3>Materials and Methods</h3><div>In this <em>in vitro</em> study, Mucoderm and Jason resorbable membranes were cut into 15 pieces each, and were inoculated with <em>S. mutans</em> at 10⁵ colony forming units (CFUs)/mL concentration. The membranes were subsequently assigned to 3 subgroups each (<em>n</em> = 5), for decontamination with TB (100 µg/mL) activated by 635 nm laser (60 s) as the experimental group (aPDT), 0.12 % chlorhexidine (CHX) as the positive control, and phosphate buffered saline (PBS) as the negative control. Changes in colony count after the interventions were calculated. Data were analyzed by the Kruskal-Wallis and Dunn's tests (alpha=0.05).</div></div><div><h3>Results</h3><div>In both membrane types, the difference in colony count was significant among the three subgroups (<em>P</em> = 0.002). The lowest colony count was noted in the CHX subgroup, and the highest was recorded in the PBS subgroup. aPDT caused a significant reduction in colony count compared with the negative control group (<em>P</em> = 0.002). Significant differences were found between all three groups in pairwise comparisons (<em>P</em> &lt; 0.05). The efficacy of aPDT was not significantly different for decontamination of the two membrane types (<em>P</em> = 635).</div></div><div><h3>Conclusion</h3><div>aPDT with 635 nm diode laser and TB had optimal efficacy (although inferior to CHX) for decontamination of both Jason and Mucoderm resorbable membranes inoculated with <em>S. mutans</em>.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104537"},"PeriodicalIF":3.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular mechanisms of the effects of photodynamic therapy on the brain: A review of the literature","authors":"Paweł Woźnicki ,&nbsp;Dorota Bartusik-Aebisher ,&nbsp;Agnieszka Przygórzewska ,&nbsp;David Aebisher","doi":"10.1016/j.pdpdt.2025.104536","DOIUrl":"10.1016/j.pdpdt.2025.104536","url":null,"abstract":"<div><div>Malignant gliomas are the most common primary brain tumors in adults. These tumors have a diverse molecular origin and a very poor prognosis. There is a lack of effective treatment at WHO grade IV glioma, and all glioblastomas progress or recur. Current treatments including surgical intervention, radiation therapy, and chemotherapy are insufficient and can cause damage to healthy brain tissue and neurological deficits. The preservation of healthy brain tissue during therapeutic intervention is made extremely difficult by the ability of malignant gliomas to diffusely infiltrate the surrounding brain parenchyma. Photodynamic therapy (PDT) is a treatment modality for glioma that can possibly overcome the inherent shortcommings of traditional therapies. Photodynamic therapy involves the use of a photosensitizer (PS) which, upon absorption of light by photosensitized tissue, triggers photochemical reactions generating reactive oxygen species (ROS) leading to the killing of tumor cells. Research focusing on the effective use of PDT in the treatment of glioma is already underway with promising results. Clinical studies on PDT for the treatment of gliomas have shown it to be a safe therapeutic modality with acceptable levels of side effects. However, some adverse sequelae have been observed during PDT of these tumours, such as increased photosensitivity, increased intracranial pressure or transient aphasia and worsening of pre-existing neurological deficits. Although the clinical sequelae of PDT are well described, the molecular mechanisms of PDT's effects on the healthy brain have not yet been thoroughly characterized. In our work, we attempt to summarize the molecular mechanisms of the effects of photosensitization on neural tissue, brain vasculature and the blood-brain barrier (BBB). We also point to findings presenting molecular approaches to protect the healthy brain from the adverse effects of photodynamic damage.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104536"},"PeriodicalIF":3.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant bronchoscopic photodynamic therapy to facilitate airway and parenchymal sparing lobectomies in two patients with central airway neuroendocrine tumors: A patient centered approach","authors":"Samridhi Gulati ,&nbsp;Julieta Osella ,&nbsp;Geoffrey Lam ,&nbsp;John P. Egan III","doi":"10.1016/j.pdpdt.2025.104535","DOIUrl":"10.1016/j.pdpdt.2025.104535","url":null,"abstract":"<div><h3>Background</h3><div>NCCN guidelines recommend surgical resection for well differentiated pulmonary neuroendocrine tumors (NETs), also known as carcinoid tumors, when they present in the lungs. Fortunately, most pulmonary NETs will not require extensive surgical resection beyond a lobectomy. We report two cases in which large pulmonary NETs would have required more extensive surgical resection, including a carinal pneumonectomy and a left lower lobe sleeve resection. However, after taking patient's preferences into account, neoadjuvant photodynamic therapy was able to decrease the overall tumor burden helping to facilitate airway and parenchymal sparing surgical lobectomies.</div></div><div><h3>Materials</h3><div>Interventional pulmonology (IP) and Cardiothoracic surgery (CTS) discussed options extensively with each patient and formulated a plan to perform neoadjuvant bronchoscopic followed by surgical resection if there were any remaining NET on follow up bronchoscopy. Both patients received infusions of porfimer sodium (Photofrin ®, Pinnacle Biologics) at 2mg/kg. Per standard protocol, they each underwent a series of bronchoscopies 48 h after infusion, in which endobronchial NET was illuminated with a fiberoptic catheter delivering up to 200J/cm per treatment. After the initial illumination bronchoscopy, a cryo probe was used to debulk necrotic tumor and allow for repeat illumination of residual tumor. Both patients received extensive education on avoiding phototoxicity.</div></div><div><h3>Outcomes</h3><div>Both patients underwent follow up restaging bronchoscopies revealing cleared central airways and only residual NET at the subsegmental level. As such, both underwent lobectomies, avoiding more extensive surgical resection. Both are free of disease at four years and 18 months follow up, respectively. Both patients were satisfied with their outcomes and the autonomy they were given in formulating their treatment plan.</div></div><div><h3>Conclusions</h3><div>While photodynamic therapy has been shown to be an effective stand alone, neoadjuvant, and adjuvant therapy for pulmonary NETs, surgical resection is still required in select patients. We present two cases of in which desired patient outcomes led to the use of neoadjuvant PDT to help facilitate airway and parenchymal sparing lobectomies, thus avoiding more extensive surgical resection and possible long-term morbidity.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104535"},"PeriodicalIF":3.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of photodynamic therapy in controlling persistent scalp infections after temporal lifting: A case report","authors":"Priscila Fernanda Campos de Menezes ,&nbsp;Vanderlei Salvador Bagnato","doi":"10.1016/j.pdpdt.2025.104538","DOIUrl":"10.1016/j.pdpdt.2025.104538","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) is a promising approach for treating infections caused by antibiotic-resistant microorganisms. This case report discusses the successful use of PDT in conjunction with antibiotics to treat a persistent scalp abscess in a patient. After multiple failed antibiotic treatments, PDT was introduced, resulting in significant improvement and eventual resolution of the infection. PDT was performed using a formulation of methylene blue in an oily base at 0.05%, applied intralesionally with an 18G cannula and also topically, followed by exposure to red LED light at 50 J/cm². The treatment resulted in the resolution of the infection after two sessions. This case highlights the potential of PDT as an adjunctive therapy in managing complex skin infections, reducing persistent inflammation, and combating bacterial resistance. Additionally, PDT is suggested as a preventive measure in the immediate postoperative period to avoid late complications that might require antibiotics, thereby reducing the risk of developing microbial resistance. Future studies should explore photosensitizers that do not cause skin staining, as can occur with methylene blue, particularly on the face.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104538"},"PeriodicalIF":3.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing visible retinal area in pediatric ultra-widefield fundus imaging: The effectiveness of mydriasis and eyelid lifting","authors":"Qingxia Wang ,&nbsp;Yuanyuan Xiao ,&nbsp;Xiaoyun Ma","doi":"10.1016/j.pdpdt.2025.104532","DOIUrl":"10.1016/j.pdpdt.2025.104532","url":null,"abstract":"<div><h3>Background</h3><div>The increase in visible retinal area (VRA) enhances the detection of peripheral retinal pathologies. This study aims to maximize the VRA in children using ultra-widefield (UWF) fundus imaging.</div></div><div><h3>Methods</h3><div>This cross-sectional, observational study included 53 children (106 eyes) who underwent examination in the Ophthalmology Department of Zhoupu Hospital from February to October 2023. Fundus images were captured using the ultra-widefield Optos imaging system (Daytona P200T). Parameters such as uncorrected visual acuity (UCVA), Spherical equivalent refraction (SER), axial length (AL), non-contact tonometry (NCT), and pupil diameters (both undilated and dilated) were measured. A custom image segmentation tool based on deep learning technology was used to quantify the VRA. The eyes were categorized into four groups: undilated without eyelid lifting, undilated with eyelid lifting, dilated without eyelid lifting, and dilated with eyelid lifting.</div></div><div><h3>Results</h3><div>Significant differences in VRA between the four groups (χ² = 79.686, <em>P</em> &lt; 0.001). Mydriasis increased VRA by 8.4 % (<em>P</em> = 0.001), eyelid lifting increased VRA by 18.1 % (<em>P</em> &lt; 0.001), and combining both increased VRA by 20 % (<em>P</em> &lt; 0.001). UCVA was negatively correlated with VRA in the undilated condition without eyelid lifting (<em>r</em>= -0.237, <em>P</em> = 0.014), SER was negatively correlated with VRA and AL was positively correlated with VRA under dilation without eyelid lifting (<em>r</em> = -0.310, <em>P</em> = 0.001; <em>r</em> = 0.264, <em>P</em> = 0.006).</div></div><div><h3>Conclusion</h3><div>Combining mydriasis with manual eyelid lifting significantly enhances the VRA in UWF fundus imaging, effectively mitigating the effects of artifacts caused by eyelashes and eyelids. This technique improves the detection rate of peripheral retinal pathologies.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104532"},"PeriodicalIF":3.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of photodynamic therapy combined with Anti-VEGF vs. Anti-VEGF monotherapy on choriocapillaris vessel density in polypoidal choroidal vasculopathy","authors":"Po-Chin Kuo ,&nbsp;Sheng-Min Hsu ,&nbsp;Yi-Hsun Huang ,&nbsp;Chun-Hsiang Chang ,&nbsp;Yi-Sheng Chang ,&nbsp;Jia-Horung Hung ,&nbsp;Chun-Chieh Lai ,&nbsp;Yu-Kuei Lee","doi":"10.1016/j.pdpdt.2025.104531","DOIUrl":"10.1016/j.pdpdt.2025.104531","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the choriocapillaris vessel density between intravitreal ranibizumab (Lucentis) (IVR) plus photodynamic therapy (PDT) and intravitreal aflibercept (Eylea) (IVA) monotherapy in patients experiencing polypoidal choroidal vasculopathy (PCV).</div></div><div><h3>Design</h3><div>An observational, retrospective cohort study.</div></div><div><h3>Subjects</h3><div>Adults with treatment-naïve PCV.</div></div><div><h3>Intervention</h3><div>IVR plus PDT or IVA monotherapy.</div></div><div><h3>Main outcome measures</h3><div>After propensity-score (PS) matching, study outcomes were compared at 1 month after the final treatment. The primary outcome was a choriocapillaris vessel density, recognized by optical coherence tomography angiography (OCTA). The secondary outcomes included best corrected visual acuity (BCVA), presence of retinal hemorrhage, central macular thickness (CMT) and subfoveal choroidal thickness (SFCT), assessed by optical coherence tomography (OCT).</div></div><div><h3>Results</h3><div>Initially, 23 patients receiving IVR plus PDT, and 75 patients receiving IVA monotherapy were included. After PS-matching, 19 eyes of 19 patients receiving IVR plus PDT and 38 eyes of 38 patients receiving IVA monotherapy were analyzed. A significantly lower choriocapillaris vessel density in the IVR plus PDT group than the IVA monotherapy group (41.9 % vs. 52.2 %, <em>p</em> = 0.009) was demonstrated. The similarity of the BCVA, occurrence and severity of retinal hemorrhage, CMT, and SFCT between two treatment groups was exhibited.</div></div><div><h3>Conclusions</h3><div>The choriocapillaris vessel density was significantly reduced in PCV patients treated with IVR plus PDT compared to those receiving IVA monotherapy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104531"},"PeriodicalIF":3.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}