Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Photobiomodulation and orthodontic root resorption: A systematic review and meta-analysis","authors":"Jing Yang,&nbsp;Qianqian Zhang,&nbsp;Dehua Zheng,&nbsp;Fengchun Hou","doi":"10.1016/j.pdpdt.2025.104659","DOIUrl":"10.1016/j.pdpdt.2025.104659","url":null,"abstract":"<div><h3>Objectives</h3><div>Orthodontically induced inflammatory root resorption (OIIRR) is a common adverse effect of orthodontic treatment, characterized by the reduction in root length and volume. Photobiomodulation (PBM), a non-invasive method, has gained attention for its potential in controlling OIIRR. This review aims to analyze and summarize randomized controlled trials (RCTs) to evaluate the impact of PBM on root resorption during orthodontic treatment in humans.</div></div><div><h3>Methods</h3><div>A systematic search was conducted using relevant keywords in the Cochrane Library, PubMed, EMBASE, Web of Science, and ScienceDirect for studies published up to January 2025. Studies were selected based on predefined inclusion and exclusion criteria. The Cochrane Risk of Bias tool (RoB 2) was used to assess the risk of bias in the included RCTs. A meta-analysis was performed using RevMan software (version 5.4), and subgroup analyses were conducted to identify sources of heterogeneity.</div></div><div><h3>Results</h3><div>Eight studies with a total of 185 participants were included in the analysis. The forest plot results demonstrated that LED interventions led to statistically significant improvements in root resorption (MD = –0.15, [95 % CI –0.19, –0.10], <em>p</em> &lt; 0.00001). While LLLT studies indicated a trend toward reduced root resorption, the results did not reach statistical significance (SMD = –1.69, [95 % CI –3.52, 0.14], <em>p</em> = 0.07). The overall change in root length was not statistically significant, except for the canine tooth, where a significant reduction in resorption was observed (MD = –0.49, 95 % CI [–0.95, –0.03], <em>p</em> = 0.04). Subgroup analysis indicated that a wavelength of 850 nm or longer, a fluence exposure greater than 10 J/cm², irradiance less than 25 mW/cm², treatment durations exceeding two minutes, and more than six treatment sessions were associated with a beneficial effect in reducing orthodontically induced inflammatory root resorption.</div></div><div><h3>Conclusion</h3><div>In conclusion, while photobiomodulation (PBM) appears to have a beneficial effect on orthodontically induced root resorption, the current body of evidence is limited, with a low number of studies and considerable heterogeneity. These findings are exploratory and require validation through high-quality trials with robust designs, standardized methods, and longer follow-ups.</div></div><div><h3>Registration</h3><div>PROSPERO registration number - CRD42023444677.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104659"},"PeriodicalIF":3.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior scleritis misdiagnosed as central serous chorioretinopathy: Case report","authors":"Lina Jiangbolati ,&nbsp;Yan Gao ,&nbsp;Qing Peng","doi":"10.1016/j.pdpdt.2025.104655","DOIUrl":"10.1016/j.pdpdt.2025.104655","url":null,"abstract":"<div><div>This case report describes a 39-year-old male presenting with serous retinal detachment (SRD) who was initially misdiagnosed with acute central serous chorioretinopathy (CSC). CSC is typically a self-limiting condition, but recurrence occurs in approximately 30–50 % of patients depending on risk factors and disease chronicity. He received antibiotics for suspected infection, but his symptoms persisted without corticosteroid use. After referral to our hospital, posterior scleritis was confirmed through inflammation signs, multimodal imaging (showing optic disc edema, extending SRD, thickened eyewall, and ciliary body detachment), and elevated systemic inflammatory biomarkers. Methylprednisolone therapy relieved symptoms within four days. Follow-up at four months showed complete SRD resolution and choroidal fold regression.</div><div>This case highlights the diagnostic challenge in patients with SRD, where demographic assumptions—such as the tendency to associate CSC with young males—may delay recognition of inflammatory etiologies like posterior scleritis. Corticosteroids, which may worsen CSC, are essential for treating posterior scleritis—highlighting the critical need for accurate differentiation to avoid therapeutic missteps and irreversible vision loss. Definitive diagnosis necessitates synthesizing ocular examination findings, systemic biomarkers, and multimodal imaging. Clinicians must prioritize integrating clinical, imaging, and laboratory data over relying on isolated SRD or demographic stereotypes to guide management in complex ophthalmic cases.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104655"},"PeriodicalIF":3.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid differentiation of patients with lung cancers from benign lung nodule based on dried serum Fourier-transform infrared spectroscopy combined with machine learning algorithms","authors":"Huanyu Li,&nbsp;Lixue Dai,&nbsp;Shaomei Guo,&nbsp;Hongluan Wang,&nbsp;Lei Lei,&nbsp;Jie Yu,&nbsp;Xiaoyun Li,&nbsp;Jun Wang","doi":"10.1016/j.pdpdt.2025.104653","DOIUrl":"10.1016/j.pdpdt.2025.104653","url":null,"abstract":"<div><div>Lung cancer (LC) is associated with poor 5-year survival rates when diagnosed at advanced stages. While low-dose computed tomography (LDCT) screening enables earlier detection, its high false-positive rate, primarily due to benign lung nodules (BLN), necessitates more accurate diagnostic tools. This study developed a rapid and precise LC discrimination method by integrating Fourier transform infrared (FTIR) spectroscopy of dried serum samples with machine learning algorithms. We analyzed dried serum from 58 LC patients, 37 BLN patients, and 36 healthy controls. Five machine learning models, linear discriminant analysis (LDA), support vector machine (SVM), random forest, multilayer perceptron (MLP), and LightGBM, were optimized using FTIR spectral data (1800–900 cm⁻¹ band). All algorithms successfully differentiated the three groups, with LDA achieving the highest accuracy (93.9 %). These results demonstrate that dried serum FTIR spectroscopy coupled with machine learning, particularly LDA, offers a promising approach for distinguishing LC from BLN, potentially augmenting LDCT screening to reduce unnecessary interventions.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104653"},"PeriodicalIF":3.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of Mohs micrographic surgery with or without photodynamic therapy for locally advanced basal cell carcinoma","authors":"Freddy Gahimbare ,&nbsp;Xurong Liu ,&nbsp;Jipang Zhan ,&nbsp;Yanyu Du,&nbsp;Renliang He,&nbsp;Lian Zhang","doi":"10.1016/j.pdpdt.2025.104633","DOIUrl":"10.1016/j.pdpdt.2025.104633","url":null,"abstract":"<div><h3>Background</h3><div>Locally advanced basal cell carcinoma (laBCC) is a more severe subtype of BCC, characterized by large, deeply invasive tumors that often occur in cosmetically or functionally sensitive areas. Mohs micrographic surgery (MMS) is the standard treatment, offering high cure rates through layer-by-layer excision with microscopic margin control. However, MMS alone may not entirely prevent recurrence in aggressive or infiltrative subtypes. Photodynamic therapy (PDT) is a non-invasive treatment modality that may enhance outcomes when used adjunctively. This study evaluated whether combining MMS with PDT offers advantages over MMS alone for laBCC.</div></div><div><h3>Method</h3><div>A retrospective cohort study was conducted with 63 patients diagnosed with laBCC, categorized by histological subtype into aggressive and non-aggressive groups. Patients were not randomized; they received either MMS alone or MMS followed by PDT based on clinical decision-making at treatment time. Clinical outcomes were analyzed, including recurrence, recurrence-free survival (RFS), and surgical margins.</div></div><div><h3>Results</h3><div>MMS group exhibited a low recurrence rate of 4.4 %, against 22.2 % for MMS+PDT group. Non-aggressive tumours such as superficial, nodular, and adenoid types, treated with MMS and PDT had a 16.7 % recurrence rate, compared to 25 % for aggressive tumours, including Infiltrating, Basosquamous, and morphea form types. This suggests that non-aggressive cases may respond better to PDT. Additionally, the mean recurrence-free survival(mRFS) time was about 54 months (95 % CI: 50- 57.3 months) for non-aggressive tumours, while aggressive tumours had a mean survival of 52.3 months (95 % CI: 51–56.2 months), indicating a potential trend favouring non-aggressive tumours.</div></div><div><h3>Conclusion</h3><div>MMS combined with PDT show favourable outcomes in non-aggressive BBC.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104633"},"PeriodicalIF":3.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of erosive pustular dermatosis of the scalp using aminolevulinic acid photodynamic therapy: A report of 2 cases","authors":"Yumeng M. Li,&nbsp;Fabrizio Galimberti","doi":"10.1016/j.pdpdt.2025.104656","DOIUrl":"10.1016/j.pdpdt.2025.104656","url":null,"abstract":"<div><div>Erosive pustular dermatosis (EPD) of the scalp is an inflammatory condition that is characterized by skin atrophy, erosions, and keratotic crusts and primarily affects elderly patients. The lesions of EPD develop over time and can lead to scarring alopecia. There are no established clinical guidelines or consensus on treatment for EPD, but some authors report success with photodynamic therapy using aminolevulinic acid as the sensitizer (ALA-PDT). This report presents 2 cases of male patients, 91 and 86 years of age, with EPD that did not resolve despite prior treatment with topical steroids or retinoids but was successfully treated using ALA-PDT. In both patients, ALA-PDT resulted in improvement of EPD of the scalp after 2 sessions, with visible progress by 6 weeks after the second ALA-PDT session. The ALA-PDT treatments were well tolerated. The cases presented here demonstrate that ALA-PDT can be a potential therapeutic option for EPD of the scalp.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104656"},"PeriodicalIF":3.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects on choroid after repeated low-level red-light therapy in preclinical and clinical myopic children: a randomized controlled trial","authors":"Hongyu Wei ,&nbsp;Sahil Thakur ,&nbsp;Qin Zhu ,&nbsp;Yanrong Zhou ,&nbsp;Xuejun Cao ,&nbsp;Shuyuan Xiao ,&nbsp;Qin Chen ,&nbsp;Min Hu ,&nbsp;Hua Zhong","doi":"10.1016/j.pdpdt.2025.104651","DOIUrl":"10.1016/j.pdpdt.2025.104651","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate how choroidal thickness (CT) and choriocapillaris flow deficit density (CCD) change within 6000 µm of the macula following repeated low-level red-light (RLRL) therapy, and to assess whether early choroidal alterations can predict long-term myopia control.</div></div><div><h3>Methods</h3><div>This is a secondary analysis of a prospective randomized controlled trial. Two hundred children with spherical equivalent refraction (SER) of -6.00D to +0.50D were randomized to receive either twice-daily RLRL therapy or no additional intervention (control). Axial length (AL), cycloplegic SER, CT, and CCD were measured at the baseline and at 1, 3, 6 and 12 months.</div></div><div><h3>Results</h3><div>Baseline characteristics were similar between groups. In the RLRL group, subfoveal choroidal thickness (SFCT) increased progressively over time, reaching its maximum at 12 months; by contrast, SFCT declined in controls. Within the 6000 µm macular zone, CT rose in the RLRL group but fell uniformly in the control group. Improvements on choriocapillaris blood flow were evident at 3 months post-RLRL, yet these changes were not sustained and did not correlate with longer-term choroidal thickening. A prediction model using only the “6-month SFCT change” demonstrated comparable accuracy for forecasting satisfactory myopia control at 12 months to more complex multivariable models.</div></div><div><h3>Conclusions</h3><div>RLRL therapy induces a marked and sustained thickening of the macular choroid within 6000 µm, while its effects on choriocapillaris perfusion are transient. Moreover, the magnitude of SFCT increase at 6 months alone provides a reliable early predictor of 12-month myopia control efficacy.</div><div><em>Trial Registration</em> This trial was registered at the Chinese Clinical Trial Registry on January 30, 2021, with trial registration number: ChiCTR2100042836. <span><span>https://www.chictr.org.cn/showprojEN.html?proj=120971</span><svg><path></path></svg></span></div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104651"},"PeriodicalIF":3.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic therapy in ocular oncology: A bibliometric analysis (1987–2024)","authors":"Ceren Türkoğlu ,&nbsp;Aslan Aykut","doi":"10.1016/j.pdpdt.2025.104654","DOIUrl":"10.1016/j.pdpdt.2025.104654","url":null,"abstract":"<div><h3>Background</h3><div>Photodynamic therapy (PDT) is a minimally invasive modality widely employed in ocular oncology, utilizing photosensitizers such as verteporfin to induce localized cytotoxic effects. While PDT is commonly applied in the management of benign intraocular tumors and selectively for malignant lesions, bibliometric analyses in this field remain scarce. This study aims to address this gap by analyzing bibliometric trends and mapping the evolution of PDT research in ocular oncology.</div></div><div><h3>Methods</h3><div>A bibliometric analysis was conducted using the Web of Science Core Collection, targeting PDT in ocular tumors. Data were screened for relevance, refined using OpenRefine, and analyzed in Microsoft Excel for publication trends. VOSviewer was used to visualize collaboration networks and keyword co-occurrence. Key indicators such as publication output, citations, authorship, institutional contributions, and journal distribution were assessed.</div></div><div><h3>Results</h3><div>A total of 177 publications (1987–2024) were identified, with original articles comprising 67.7 %. The United States led in publication count (<em>n</em> = 63), total citations (1074), and H-index (20). <em>Investigative Ophthalmology &amp; Visual Science</em> and <em>Retina</em> were the most prolific journals. A decline in publication volume was noted post-2020, coinciding with a global verteporfin shortage. Keyword analysis showed a primary focus on circumscribed choroidal hemangioma, with recent interest shifting toward metastasis and alternative therapies. The most prolific authors were Shields CL and Shields JA, while Schmidt-Erfurth U had the highest citation count.</div></div><div><h3>Conclusion</h3><div>This study presents a comprehensive bibliometric mapping of PDT in ocular oncology, highlighting research trends, influential contributors, and the impact of external factors on scholarly output.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104654"},"PeriodicalIF":3.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeatability and agreement of three biometers measuring corneal keratometry and astigmatism in eyes with cataract and high myopia","authors":"Haisheng Zhou ,&nbsp;Tong Bao ,&nbsp;Shuchan Li ,&nbsp;Yunlei Pang ,&nbsp;Qinglei Shao ,&nbsp;Lifeng Wang ,&nbsp;Lihua Yin ,&nbsp;Jinli Wang ,&nbsp;Na Hu ,&nbsp;Yuanyuan Qi ,&nbsp;Bozhou Zhang","doi":"10.1016/j.pdpdt.2025.104652","DOIUrl":"10.1016/j.pdpdt.2025.104652","url":null,"abstract":"<div><h3>Background</h3><div>Accurate ocular biometric measurements are essential for intraocular lens (IOL) power calculation and postoperative refractive assessment. Various diagnostic devices, including the IOL Master 700, OPD-SCAN III, and Pentacam Scheimpflug system, are commonly used to measure corneal curvature and astigmatism. However, discrepancies between these devices may exist, particularly in patients with high myopia. This study aimed to evaluate the agreement and interchangeability of keratometric (K1, K2) and astigmatism (AST) measurements obtained from these three devices in patients with cataracts and high myopia.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 30 eyes from 30 patients with mild-to-moderate cataracts and high myopia. Each participant underwent keratometric measurements using the IOL Master 700, OPD-SCAN III, and Pentacam Scheimpflug system. Differences between devices were assessed using one-way ANOVA with Bonferroni’s post hoc test. Pearson’s correlation coefficients were calculated to assess inter-device correlations, and Bland-Altman plots were used to evaluate agreement and interchangeability.</div></div><div><h3>Results</h3><div>Strong correlations were observed among the three devices for K1 (<em>r</em> &gt; 0.96, <em>p</em> &lt; 0.001) and K2 (<em>r</em> &gt; 0.95, <em>p</em> &lt; 0.001) measurements, while AST showed slightly lower correlations (<em>r</em> &gt; 0.77, <em>p</em> &lt; 0.001). Significant differences were noted in K1 between Pentacam and the other two devices (<em>p</em> &lt; 0.01), while K2 and AST exhibited varying degrees of disagreement. Bland-Altman analysis demonstrated narrow 95 % limits of agreement, but systematic differences were identified, particularly in AST measurements.</div></div><div><h3>Conclusion</h3><div>Despite strong correlations, significant inter-device differences suggest that keratometric and astigmatism measurements from these three devices are not fully interchangeable. Clinicians should be cautious when using different devices for preoperative assessments and IOL power calculations in patients with high myopia. Further research is needed to refine measurement algorithms and optimize clinical accuracy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104652"},"PeriodicalIF":3.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on “Photodynamic therapy with hematoporphyrin derivative for recurrent plantar cutaneous squamous cell carcinoma: A case report”","authors":"Guijun liu ,&nbsp;Tianming Ma","doi":"10.1016/j.pdpdt.2025.104650","DOIUrl":"10.1016/j.pdpdt.2025.104650","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104650"},"PeriodicalIF":3.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of ALA-PDT for epidermoid cyst on the face: A retrospective study","authors":"Haiyan Zhang ,&nbsp;Yu Yan ,&nbsp;Yan Zhao ,&nbsp;Zhongxia Zhou ,&nbsp;Jiawen Gao ,&nbsp;Ronald Sroka ,&nbsp;Linglin Zhang ,&nbsp;Xiuli Wang","doi":"10.1016/j.pdpdt.2025.104641","DOIUrl":"10.1016/j.pdpdt.2025.104641","url":null,"abstract":"<div><div>Background: Epidermoid cysts are usually single, benign, keratin-filled cysts which occur mainly on the face and upper trunk of young adults. Surgical resection is the main treatment, which inevitably leaves scars and may recur. Photodynamic therapy (PDT) has been reported as a non-invasive and promising treatment for various skin diseases with cosmetic benefits.</div><div>Methods: 14 patients with single epidermoid cyst located on the face received ALA-PDT treatment. After the plum-blossom needle pretreatment, cyst was incubated with 5 % ALA cream for 30 min and then irradiated with 633 nm LED red light. If complete remission wasn’t achieved after one session of ALA-PDT treatment, more sessions would be repeated once every 1–2 weeks. Follow-ups were conducted every 2 weeks after the end of treatment.</div><div>Results: All patients achieved complete regression of cyst after 1 to 3 ALA-PDT sessions. None of the patients experienced recurrence or scarring during the follow-up period (0.5 to 28months). Mild adverse effects were observed, including transient pain, erythema, and edema.</div><div>Conclusion: In this observational study, ALA-PDT showed good efficacy and mild adverse reactions, suggesting that ALA-PDT is a promising treatment for epidermoid cysts on the face with cosmetic benefits.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104641"},"PeriodicalIF":3.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}