Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Kaplan-Meier survival analysis of Mohs micrographic surgery with or without photodynamic therapy for locally advanced basal cell carcinoma","authors":"Sunny Chi Lik Au","doi":"10.1016/j.pdpdt.2025.105302","DOIUrl":"10.1016/j.pdpdt.2025.105302","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105302"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased choroidal stromal volume and altered choriocapillaris perfusion in neovascular AMD: An SS-OCTA association study","authors":"Xuelin Chen ,&nbsp;Xuenan Zhuang ,&nbsp;Guiqin He ,&nbsp;Miaoling Li ,&nbsp;Xiongze Zhang ,&nbsp;Jiaxin Pu ,&nbsp;Yuying Ji ,&nbsp;Yining Zhang ,&nbsp;Xinlei Hao ,&nbsp;Feng Wen","doi":"10.1016/j.pdpdt.2025.105327","DOIUrl":"10.1016/j.pdpdt.2025.105327","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to characterize quantitative choroidal metrics using swept-source optical coherence tomography angiography (SS-OCTA) across different stages associated with neovascular age-related macular degeneration (nAMD) and to identify structural and vascular associations.</div></div><div><h3>Methods</h3><div>This cross-sectional study utilized SS-OCTA to quantify 6.0 × 6.0 mm² macular choriocapillaris flow density (CCFD), choroidal volume (CV), choroidal stromal volume (CSV), and choroidal vascular volume (CVV), choroidal stromal index (CSI), choroidal vascularity index (CVI) and CSV/CVV ratio. Comparisons were conducted between each pair of three groups: control eyes from healthy participants, fellow eyes and nAMD affected eyes from the same unilateral nAMD patients (fellow eyes representing a potential preclinical stage).</div></div><div><h3>Results</h3><div>The study included 230 healthy control eyes from 116 age- and sex- matched participants, 110 unaffected fellow eyes and 104 nAMD affected eyes from 110 unilateral nAMD patients. Median CCFD was 45.33% (IQR: 4.82%) in controls, 46.50% (IQR: 2.35%) in fellow eyes and 44.41% (IQR: 6.68%) in nAMD eyes. Significant differences were found between controls and fellow eyes (Adjusted <em>P</em> = 0.003) and between fellow eyes and nAMD eyes (Adjusted <em>P</em> &lt; 0.001). Median CSV was significantly higher in both unaffected fellow eyes (5.92 mm³, IQR: 2.67 mm³; Adjusted <em>P</em> = 0.006) and nAMD affected eyes (6.12 mm³, IQR: 2.71 mm³; Adjusted <em>P</em> = 0.012) compared to controls (5.49 mm³, IQR: 2.00 mm³). Other absolute volumes also showed significant intergroup differences: CV differed between control and fellow eyes (Adjusted <em>P</em> = 0.033), while CVV differed significantly only between affected and fellow eyes (Adjusted <em>P</em> = 0.015). In contrast, normalized compositional metrics (CSI, CVI and CSV/CVV ratio) showed no significant intergroup differences (all Adjusted <em>P</em> &gt; 0.05). Multivariate regression analysis in nAMD affected eyes revealed an overall inverse correlation between CSV and CCFD, with this relationship reaching statistical significance the superior nasal, nasal, inferior temporal, inferior and inferior nasal quadrants (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This cross-sectional study demonstrated an association between increased CSV and the presence of nAMD, including in high-risk fellow eyes. The inverse correlation between CSV and CCFD in nAMD eyes suggested a potential interplay between stromal expansion and microvascular compromise. These findings highlighted increased CSV as a candidate biomarker that warranted investigation in future longitudinal studies to determine its prognostic value for nAMD development.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105327"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using a new type of visible light-based emission fluorescence microscope to identify the benign and malignant nature of thyroid tissue during the surgical process: Analysis of diagnostic results","authors":"Yu Miao ,&nbsp;Liu Xiaowei ,&nbsp;Li Muyang ,&nbsp;Gao Jian ,&nbsp;Chen Lu","doi":"10.1016/j.pdpdt.2025.105324","DOIUrl":"10.1016/j.pdpdt.2025.105324","url":null,"abstract":"<div><h3>Objective</h3><div><strong>:</strong> This study evaluated the accuracy and reliability of a new type of visible light-based emission fluorescence microscope [the EndoSCell cell optical scanner (EndoSCell)] in identifying the pathological features of papillary thyroid carcinoma, the spread of lymph nodes in the neck, and the parathyroid glands.</div></div><div><h3>Method</h3><div><strong>:</strong> The thyroid papillary carcinoma tissue samples, lymph node tissue samples, and parathyroid tissue samples were diagnosed using EndoSCell images and frozen sections, and the detection times were recorded. The Hematoxylin and eosin (HE) staining results were used as the gold standard.</div></div><div><h3>Result</h3><div><strong>:</strong> EndoSCell boasts extremely high imaging clarity, enabling it to clearly distinguish the spatial distribution and morphological characteristics of stained cell nuclei and cytoplasm within the observed tissue samples (healthy tissues, lesion areas). The sensitivity, specificity and accuracy of using EndoSCell images to determine the benign or malignant nature of thyroid papilloma, the presence of cervical lymph node metastasis, and the status of parathyroid tissue were (96.43%, 100%, 97.22%), (92.6%, 92.3%, 92.5%), and (91.3%, 91.7%, 91.4%), respectively. The detection times for EndoSCell and frozen sections were 180.77 ± 45.03 s and 1835 ± 538.12 s respectively.</div></div><div><h3>Conclusion</h3><div><strong>:</strong> The diagnostic efficacy of EndoSCell is comparable to that of frozen sections, and the diagnostic results of EndoSCell are highly consistent with the pathological diagnosis of frozen sections. EndoSCell is expected to enable doctors to precisely and accurately remove cancerous tissues in real time while protecting important tissues such as the parathyroid glands and the recurrent laryngeal nerve.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105324"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axial and choroidal changes as key predictors of myopia control in red-light therapy: Evidence from machine learning models","authors":"Xiaoxue Hu ,&nbsp;Zixun Wang ,&nbsp;Rui Li ,&nbsp;Boxuan Sun ,&nbsp;Dingkang Wang ,&nbsp;Hui Zong ,&nbsp;Xiaoling Zhang ,&nbsp;Ruihua Wei ,&nbsp;Hong Jie","doi":"10.1016/j.pdpdt.2026.105342","DOIUrl":"10.1016/j.pdpdt.2026.105342","url":null,"abstract":"<div><h3>Background</h3><div>Repeated low-level red-light (RLRL) therapy has emerged as a promising non-invasive intervention for myopia control. However, the predictive factors underlying its efficacy remain insufficiently explored.</div></div><div><h3>Methods</h3><div>This multicenter cohort study included 538 pediatric patients who underwent RLRL treatment with a minimum follow-up of one year. Baseline ocular parameters and dynamic changes in axial length (AL) and choroidal thickness (ChT) over three months were collected. Multiple feature selection approaches—LASSO regression, Boruta, recursive elimination, and multivariate regression—were applied. Seven machine learning algorithms were trained, and their performance was evaluated using the area under the curve (AUC), sensitivity, specificity, and F1 score. SHAP and LIME analyses were utilized for interpretability.</div></div><div><h3>Results</h3><div>Logistic regression and gradient boosting models demonstrated the highest discriminative ability. XGBoost achieved optimal performance (AUC: 0.90–0.92; accuracy: 87.7–88.2 %; F1 score: 0.72–0.86). Across one- and two-year prediction models, six stable predictors were identified: age, baseline AL, anterior chamber depth (ACD), RNFL thickness at the temporal inferior quadrant (TI), ChangeAL, and ChangeChT. SHAP analysis revealed that ChangeAL was the dominant short-term predictor, whereas ChangeChT was most influential for long-term outcomes. Older age and greater choroidal thickening were consistently associated with a protective effect against myopia progression.</div></div><div><h3>Conclusions</h3><div>We developed and validated an interpretable machine learning model that accurately predicts short- and long-term outcomes of RLRL therapy in children. ChangeAL and ChangeChT serve as key dynamic biomarkers for treatment monitoring. These findings provide a foundation for personalized clinical decision-making in myopia management.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105342"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145946649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of insulin therapy with diabetic retinopathy in type 2 diabetes: A cross-sectional analysis from the Beichen Eye Study","authors":"Jingyao Liu,&nbsp;Qianhui Yang,&nbsp;Juping Liu,&nbsp;Xiaorong Li","doi":"10.1016/j.pdpdt.2026.105345","DOIUrl":"10.1016/j.pdpdt.2026.105345","url":null,"abstract":"<div><h3>Purpose</h3><div>To describe and investigate the associations between different glucose-lowering management and diabetic retinopathy (DR).</div></div><div><h3>Methods</h3><div>Our study was a cross-sectional analysis. By comparing different glucose-lowering management methods, we aim to explore their impact on the occurrence of diabetic retinopathy (DR) and their influence on its severity. Logistic regression models were used to estimate the odds ratio (OR).</div></div><div><h3>Results</h3><div>Through the Beichen Eye Study (BCES), 844 patients were included in the cross-sectional analysis. The prevalence of DR was 19.30% among patients on oral hypoglycemic agents (OHA), 50.00% on insulin treatment, and 37.12% among those on combined use, giving an overall frequency of 24.65%. No statistically significant differences were observed among different types of oral hypoglycemic agents on the incidence and severity of DR. Logistic regression showed insulin therapy was associated with the prevalence of DR [insulin: OR= 3.57 (95% CI: 1.16 ∼ 11.05), p= 0.027; combination: OR= 2.01 (95% CI: 1.39 ∼ 2.91), p&lt; 0.001].</div></div><div><h3>Conclusion</h3><div>Compared with OHA, either increasing insulin therapy or using insulin alone can be a risk factor for DR, yet it has no impact on DR severity.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105345"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior segment structural changes across myopia severity and their association with myopia progression: A large-scale clinical analysis","authors":"He Du ,&nbsp;Bo Deng ,&nbsp;Yang Cao","doi":"10.1016/j.pdpdt.2026.105352","DOIUrl":"10.1016/j.pdpdt.2026.105352","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to investigate the variations in anterior segment parameters among patients with different degrees of myopia and explore their impact on myopia progression.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on ocular parameters of 4392 patients who underwent myopia correction surgery at the affiliated hospital of Southwest Medical University from January 2019 to January 2023. The patients were categorized into mild, moderate, and high myopia groups based on the severity of their myopia. Measurements of corneal thickness (CCT), intraocular pressure (IOP), axial length (AL), steep corneal curvature (Ks), flat corneal curvature (Kf), white-to-white corneal diameter (WTW), pupil diameter under bright conditions (LPD), pupil diameter under dark-adapted conditions (DPD), corneal volume (CV), anterior chamber volume (ACV), anterior chamber depth (ACD), and Kappa angle values (Kx and Ky) were performed and analyzed using SPSS 28.0 software.</div></div><div><h3>Results</h3><div>Significant differences were observed in most of the aforementioned parameters among patients with different degrees of myopia. With increasing myopia severity, CCT, IOP, AL, Ks, Kf, CV, ACV, ACD, and Ky exhibited a gradual increase (all <em>P</em> &lt; 0.05), while WTW and DPD showed a gradual decrease (all <em>P</em> &lt; 0.05). Kx and LPD did not exhibit statistically significant differences (<em>P</em> &gt; 0.05). Correlation analysis revealed significant positive correlations between IOP and the degree of myopia (OR = 1.02, <em>P</em> = 0.005), WTW and the degree of myopia (OR = 0.47, <em>P</em> &lt; 0.001), ACV and the degree of myopia (OR = 1.01, <em>P</em> &lt; 0.001), and significant negative correlations between ACD and the degree of myopia (OR = 0.83, <em>P</em> = 0.031). Ky showed a significant positive correlation with the degree of myopia (OR = 2.55, <em>P</em> &lt; 0.001). These findings provide further evidence of the association between ocular parameters and myopia progression.</div></div><div><h3>Conclusion</h3><div>Significant differences exist in anterior segment parameters among patients with varying degrees of myopia, which may be related to myopia progression. Further investigation into the relationship between these parameters and the development of myopia will contribute to a better understanding of the underlying mechanisms and provide a theoretical basis for scientific myopia prevention and control.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105352"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction model for the risk of vitreous haemorrhage after vitrectomy combined with intraocular injection for the treatment of proliferative diabetic retinopathy","authors":"Shasha Yao,&nbsp;Chunfang Gan,&nbsp;Rugang Pan","doi":"10.1016/j.pdpdt.2025.105313","DOIUrl":"10.1016/j.pdpdt.2025.105313","url":null,"abstract":"<div><h3>Objective</h3><div>The purpose of this study was to develop a lightweight multimodal deep learning model for accurately predicting the risk of postoperative vitreous cavity haemorrhage (POVCH) following vitrectomy with intraocular pharmacotherapy in patients with proliferative diabetic retinopathy (PDR).</div></div><div><h3>Methods</h3><div>This retrospective study included patients with PDR who underwent vitrectomy combined with intraocular medication for the first time. After applying the exclusion criteria, 1318 eyes from 968 patients were analysed. A lightweight multimodal deep learning model was developed by integrating ultra-widefield fluorescein angiography images, processed using an EfficientNet-V2 backbone, using clinical data from a multilayer perceptron. The model was trained and evaluated using a stratified four-fold cross-validation approach, and an independent external test set comprising 264 eyes was used to assess generalisability.</div></div><div><h3>Results</h3><div>On the external test set, the model achieved an area under the receiver operating characteristic curve (AUROC) of 0.978 (95 % CI: 0.952–0.994) and an area under the precision-recall curve of 0.957. Accuracy was 0.914, with a Brier score of 0.056. The model demonstrated excellent calibration (slope: 0.97; intercept: −0.03). Decision curve analysis indicated a net benefit increase of 0.031 at a 25 % risk threshold. Interpretability analyses revealed that the model’s focus, via Gradient-weighted Class Activation Mapping Plus, aligned with clinical areas of neovascularisation and retinal ischaemia. SHapley Additive exPlanations analysis identified the ischaemia index, leakage index and neovascularisation area as key predictors. The model outperformed the best traditional CatBoost model, with an absolute AUROC improvement of 0.09.</div></div><div><h3>Conclusion</h3><div>The lightweight multimodal deep learning model integrating ultra-widefield fluorescein angiography images and clinical data demonstrated advantages in predicting the risk of POVCH after PDR surgery, with high accuracy, good calibration, excellent clinical utility and interpretability and low resource requirements.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105313"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of the combination of trephination abrasion with 5-aminolevulinic acid photodynamic therapy for verruca plana: A retrospective study","authors":"Li-chao Zhang ,&nbsp;Hai-feng Huang ,&nbsp;Xian-fei Guo","doi":"10.1016/j.pdpdt.2025.105314","DOIUrl":"10.1016/j.pdpdt.2025.105314","url":null,"abstract":"<div><h3>Background</h3><div>Studies have shown that photodynamic therapy (PDT) is an effective and non-invasive technique for treating verruca plana. However, due to the limited penetration depth of photosensitizers and light sources, the efficacy of PDT for patients with verruca plana is still limited. Herein, we adopted trephination abrasion combined with 5-aminolevulinic acid (ALA) PDT for verruca plana.</div></div><div><h3>Methods</h3><div>A retrospective study of trephination abrasion combined with ALA-PDT for verruca plana was conducted. After the warts were superficially abraded by a disposable biopsy punch as trephine, ALA-PDT was performed. The effective rate was calculated with the cured and excellent response rates.</div></div><div><h3>Results</h3><div>A total of 50 patients were reported in this study. At the second week, 25 (50.0 %) patients showed complete response and 10 (20.0 %) patients showed excellent response, resulting in a total effectiveness rate of 70.0 %. At the fourth week, 47 (94.0 %) patients showed complete response and one (2.0 %) patient showed excellent response, resulting in a total effectiveness rate of 96.0 %. At the sixth week, 49 (98.0 %) patients showed complete response and one (2.0 %) patient showed excellent response, resulting in a total effectiveness rate of 100.0 %. Two (4.1 %) patients experienced recurrence at the 24th week, resulting in a total effectiveness rate of 96.0 %. At the 6-month follow-up, no hyperpigmentation was observed.</div></div><div><h3>Conclusions</h3><div>A combination of trephination abrasion with ALA-PDT was safe, economical and effective in treatment for verruca plana.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105314"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of 5-aminolevulenic acid fluorescence for diagnostic guidance in intracranial lymphoma surgery: A case series and systematic review of 170 patients","authors":"Dong-Won Shin,&nbsp;Joon-Hyuk Jeong,&nbsp;Gi-Taek Yee","doi":"10.1016/j.pdpdt.2025.105318","DOIUrl":"10.1016/j.pdpdt.2025.105318","url":null,"abstract":"<div><h3>Background</h3><div>Intracranial lymphomas are rare tumors of the central nervous system, predominantly affecting elderly patients. While 5-aminolevulinic acid (5-ALA) fluorescence is well established in glioma surgery, its diagnostic role in intracranial lymphoma remains unclear, particularly regarding the effect of corticosteroid use. This study evaluated the diagnostic performance of 5-ALA-guided biopsy and its relationship with corticosteroid exposure.</div></div><div><h3>Methods</h3><div>We conducted a retrospective case series and a systematic review. Adult patients who underwent stereotactic or open biopsy with 5-ALA guidance for radiologically suspected intracranial lymphoma at Gachon University Gil Medical Center (2022–2025) were analyzed. A comprehensive literature search (MEDLINE, EMBASE, Web of Science, Cochrane Library) through May 2025 identified studies reporting 5-ALA use in intracranial lymphoma biopsy. Diagnostic yield, fluorescence patterns, and corticosteroid effects were assessed.</div></div><div><h3>Results</h3><div>Five patients were included in the institutional series: strong fluorescence was observed in four and vague in one, with an overall positive predictive value of 80 %. Across 18 studies (170 patients), 5-ALA fluorescence was detected in 77.6 %, with 78 % pooled sensitivity and 22 % false-negative rate. Among 12 patients with documented corticosteroid use, discontinuation ≥7 days before biopsy correlated with higher fluorescence positivity, though not consistently with diagnostic success.</div></div><div><h3>Conclusions</h3><div>5-ALA fluorescence serves as a useful adjunct for intracranial lymphoma biopsy, enhancing sampling efficiency and procedural safety. However, fluorescence alone cannot ensure diagnostic adequacy, and frozen section confirmation remains necessary. Corticosteroid use does not uniformly suppress fluorescence but may influence diagnostic reliability.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105318"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world data of verteporfin-related ocular adverse events: A disproportionality analysis","authors":"Nesrin Caglayan Duman ,&nbsp;Aslihan Uzun","doi":"10.1016/j.pdpdt.2025.105322","DOIUrl":"10.1016/j.pdpdt.2025.105322","url":null,"abstract":"<div><h3>Aim/Background</h3><div>To investigate verteporfin-induced ocular adverse events (AEs) by analysing real-world data reported in the US Food and Drug Administration's Adverse Event Reporting System (FAERS) database.</div></div><div><h3>Methods</h3><div>The OpenVigil 2.1-MedDRA-v24 disproportionality analysis software package, including the Reporting Odds Ratio (ROR) and Proportional Reporting Ratio (PRR) algorithms, was used to detect potential ocular AEs associated with verteporfin and to determine signal intensity. AE reports related to verteporfin as the primary suspect in the FAERS database between 01 January 2004 and 31 December 2024 were included in the study. The signal strengths were classified as low, medium and strong according to the ROR and PRR values.</div></div><div><h3>Results</h3><div>The most reported preferred terms (PTs) were ‘visual acuity reduced’ (<em>n</em> = 212), ‘retinal haemorrhage’ (<em>n</em> = 100), and ‘choroidal neovascularization’ (<em>n</em> = 77). However ‘polypoidal choroidal vasculopathy’ (ROR=3538.345, PRR=3420.433), ‘subretinal fibrosis’ (ROR=3376.777, PRR=3283.005) and ‘macular scar’ (ROR=2458.542, PRR=2414.169) had the highest signal strength. The results of disproportionality analysis of PTs with 3 or more ‘eye disorder’ reports associated with verteporfin (<em>n</em> = 52), revealed 40 strong, 7 moderate, and 5 weak signal intensities.</div></div><div><h3>Conclusion</h3><div>The most common verteporfin-related ocular AEs (reduced visual acuity, retinal haemorrhage and choroidal neovascularization) were consistent with the drug label. However dozens of new potential ocular AEs with strong signal strengths that were not listed in the drug label, were identified. It should be noted that the proportional data in the study cannot provide information about other drugs used for the same indications as verteporfin. A fully-comprehension of these AEs will be highly beneficial in deciding which patients should be closely monitored for verteporfin-related ocular AEs. However, we emphasis our view that this study should be supported by prospective, clinically conducted research, as data on verteporfin's therapeutic indications and dosage are unavailable in this study.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105322"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}