Efficacy of ALA-PDT for epidermoid cyst on the face: A retrospective study

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-05-26 DOI:10.1016/j.pdpdt.2025.104641

Haiyan Zhang , Yu Yan , Yan Zhao , Zhongxia Zhou , Jiawen Gao , Ronald Sroka , Linglin Zhang , Xiuli Wang

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引用次数: 0

Abstract

Background: Epidermoid cysts are usually single, benign, keratin-filled cysts which occur mainly on the face and upper trunk of young adults. Surgical resection is the main treatment, which inevitably leaves scars and may recur. Photodynamic therapy (PDT) has been reported as a non-invasive and promising treatment for various skin diseases with cosmetic benefits.

Methods: 14 patients with single epidermoid cyst located on the face received ALA-PDT treatment. After the plum-blossom needle pretreatment, cyst was incubated with 5 % ALA cream for 30 min and then irradiated with 633 nm LED red light. If complete remission wasn’t achieved after one session of ALA-PDT treatment, more sessions would be repeated once every 1–2 weeks. Follow-ups were conducted every 2 weeks after the end of treatment.

Results: All patients achieved complete regression of cyst after 1 to 3 ALA-PDT sessions. None of the patients experienced recurrence or scarring during the follow-up period (0.5 to 28months). Mild adverse effects were observed, including transient pain, erythema, and edema.

Conclusion: In this observational study, ALA-PDT showed good efficacy and mild adverse reactions, suggesting that ALA-PDT is a promising treatment for epidermoid cysts on the face with cosmetic benefits.

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ALA-PDT治疗面部表皮样囊肿疗效的回顾性研究。

背景：表皮样囊肿通常是单一的、良性的、充满角蛋白的囊肿，主要发生在年轻人的面部和上肢。手术切除是主要的治疗方法，不可避免地会留下疤痕并可能复发。光动力疗法（PDT）已被报道为一种无创和有前途的治疗各种皮肤疾病的美容效益。方法：对14例面部单表皮样囊肿患者进行ALA-PDT治疗。梅花针预处理后，用5% ALA乳膏孵育囊肿30min，然后用633 nm LED红光照射。如果在一次ALA-PDT治疗后未达到完全缓解，则每1-2周重复一次。治疗结束后每2周随访一次。结果：所有患者经过1 ~ 3次ALA-PDT治疗后，囊肿完全消退。在随访期间（0.5 ~ 28个月），所有患者均未出现复发或瘢痕形成。观察到轻微的不良反应，包括短暂的疼痛，红斑和水肿。结论：在本观察性研究中，ALA-PDT疗效良好，不良反应轻微，提示ALA-PDT是一种治疗面部表皮样囊肿的有希望的美容方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.