Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Comparative efficacy of topical 5-aminolevulinic acid versus Hiporfin photodynamic therapy in HPV-positive cervical intraepithelial neoplasia grade II","authors":"Lina Geng , Wenyu Mo , Guanwen Gao , Zhihong Liu , Danfang Yuan , Qianyu Huang , Changzhong Li","doi":"10.1016/j.pdpdt.2025.105329","DOIUrl":"10.1016/j.pdpdt.2025.105329","url":null,"abstract":"<div><h3>Objective</h3><div>Given the global trend of delayed childbearing, the feasibility of non-surgical treatments—such as photodynamic therapy and conservative management—for CIN II has become an area of increasing research interest. Photodynamic therapy can be administered either systemically or locally; however, there remains a lack of consensus regarding its optimal clinical application. Based on rigorous patient selection, comprehensive informed consent, and a structured follow-up protocol, this study aims to evaluate and compare the therapeutic efficacy of different photodynamic therapy modalities and conservative treatment in patients with CIN II, thereby providing evidence-based guidance for individualized clinical management.</div></div><div><h3>Methods</h3><div>A retrospective analysis was carried out on 111 patients with CIN2 at Peking University Shenzhen Hospital and Zhujiang Hospital of Southern Medical University from October 2019 to December 2024. According to the inclusion and exclusion criteria, 46 patients were treated with ALA-PDT,32 with HPF-PDT, and 33 were assigned to the follow-up observation group. In the first month post-PDT treatment, two groups were followed up. All three groups were followed up during the 3rd to 5th months and the 6th to 12th months. Key evaluation metrics included the effectiveness of cervical lesion treatment and the rate of HR-HPV infection clearance.</div></div><div><h3>Results</h3><div>At the first month follow-up, three patients in the HPF-PDT group exhibited allergic reactions. At the 3rd to 5th months follow-up, three patients in the HPF-PDT group were found to have cervical canal adhesions. The efficacy rates following ALA-PDT at 3rd-5th months and 6th-12th months were 93.0% (40/43) and 100% (27/27), compared to 90.3% (28/31) and 95.7% (22/23) after HPF-PDT.HPV clearance rates following ALA-PDT at 3rd-5th and 6th-12th months were 58.7% (27/46) and 77.8% (21/27) compared to 46.9%(15/32) and 62.5% (15/24) after HPF-PDT, with no significant difference between the two groups (<em>P</em> = 0.675 at 3rd-5th months, <em>P</em> = 0.274 at 6th-12th months; <em>P</em> = 0.303 and <em>P</em> = 0.705, respectively). Both rates were significantly higher than those of the observation group (39.4% (13/33) and 62.1% (18/29), <em>P</em> < 0.0001 and <em>P</em> < 0.0001; 6.1% (2/33) and 10.3% (3/29), <em>P</em> < 0.0001 and <em>P</em> < 0.0001). Due to follow-up discontinuation for some patients from June to December, a sensitivity analysis using March–May data yielded consistent results.</div></div><div><h3>Conclusions</h3><div>While both ALA-PDT and HPF-PDT demonstrate comparable and high efficacy for CIN2, their risk-benefit profiles are distinct. HPF-PDT is associated with a clinically significant risk of cervical adhesions and potentially burdensome, prolonged systemic photosensitivity. Therefore, for patients without endocervical involvement, ALA-PDT presents a superior safety profile and ","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105329"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Using a new type of visible light-based emission fluorescence microscope to identify the benign and malignant nature of thyroid tissue during the surgical process: Analysis of diagnostic results” [Photodiagnosis and Photodynamic Therapy 57 (2026) 105324]","authors":"Yu Miao , Liu Xiaowei , Li Muyang , Gao Jian , Chen Lu","doi":"10.1016/j.pdpdt.2026.105410","DOIUrl":"10.1016/j.pdpdt.2026.105410","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105410"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced in vitro photodynamic therapy for triple-negative breast cancer by pheophorbide a-encapsulated chitosan-tripolyphosphate nanoparticles","authors":"Wen-Yao Yin ,&nbsp;Zih-You Lin ,&nbsp;Mei-Ying Wang ,&nbsp;Dhivyabharathi Balakrishnan ,&nbsp;Cheng-I Lee","doi":"10.1016/j.pdpdt.2025.105332","DOIUrl":"10.1016/j.pdpdt.2025.105332","url":null,"abstract":"<div><div>Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer. Current treatment strategies typically involve surgical resection and chemotherapy, both of which are often associated with significant adverse effects. As an alternative, photodynamic therapy (PDT) offers a minimally invasive approach to selectively target tumor cells. In this work, PDT was evaluated using pheophorbide a (Pa) as a photosensitizer. To enhance its therapeutic efficacy, Pa was encapsulated in ionically crosslinked chitosan/tripolyphosphate (TPP) nanoparticles. Furthermore, nanoparticles synthesized from chitosan subjected to various pre-treatments were compared in terms of their physicochemical properties. The optimized Pa-loaded chitosan/TPP nanoparticles (PaCNPs) exhibited enhanced singlet oxygen (¹O₂) generation upon photoactivation of Pa. Cellular uptake and intracellular distribution of Pa were extensively examined in MDA-MB-453 and MDA-MB-231 cell lines. Notably, nanoparticle encapsulation resulted in a fourfold reduction in IC₅₀ in MDA-MB-231 cells, whereas no significant change was observed in MDA-MB-453 cells. The distinct responses of these cell lines to PaCNPs-mediated PDT in are further discussed.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105332"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of magnesium-conditioned chitosan hydrogels and photobiomodulation on MC3T3-E1 preosteoblast function","authors":"Hao-Hsuan Chiu ,&nbsp;Pei-Chun Wong ,&nbsp;Ying-Chun Chen","doi":"10.1016/j.pdpdt.2025.105307","DOIUrl":"10.1016/j.pdpdt.2025.105307","url":null,"abstract":"<div><h3>Background</h3><div>Magnesium (Mg) and photobiomodulation (PBM) have independently been reported to promote osteogenesis, but their combined effects remain unclear.</div></div><div><h3>Methods</h3><div>Mg-conditioned chitosan hygrogels (0,20, and 50 mol%) were prepared, and conditioned media were applied to MC3T3-E1 preosteoblasts with or without near-infrared PBM (830 nm, 5 J/cm²). Cell viability, migration, and calcium deposition were assessed (<em>n</em> = 3 biological replicates per group).</div></div><div><h3>Results</h3><div>High Mg reduced cell migration and mineralization, whereas PBM significantly enhanced calcium deposition and partially restored viability at early time points (<em>p</em> &lt; 0.05). A notable synergistic effect was observed at 20 mol% Mg combined with PBM, particularly at specific time points, indicating a condition-dependent rather than uniformly optimal response.</div></div><div><h3>Conclusion</h3><div>The combination of Mg-conditioned hydrogels and PBM enhanced osteogenic responses in MC3T3-E1 preosteoblasts. This dual-modality strategy may inform scaffold design in bone tissue engineering.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105307"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145703591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting RNFL thinning and age subgroups in keratoconus: clarifying model choice, effect-size considerations, and quality appraisal","authors":"Hadi Vahedi","doi":"10.1016/j.pdpdt.2025.105270","DOIUrl":"10.1016/j.pdpdt.2025.105270","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105270"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Er Cr: YSGG laser, ytterbium fiber laser, and Rose Bengal-activated low-level laser therapy on roughness and shear bond strength of yttria-stabilized zirconia","authors":"Ghadeer I Basunbul","doi":"10.1016/j.pdpdt.2025.104784","DOIUrl":"10.1016/j.pdpdt.2025.104784","url":null,"abstract":"<div><h3>Aim</h3><div>Effect of Er Cr: YSGG laser (ECL), ytterbium fiber laser (YFL), Rose Bengal (RB) activated low-level laser therapy (LLLT) on the surface roughness (Ra) and shear bond strength (SBS) of yttrium-stabilized tetragonal zirconia polycrystal (Y-TZP) bonded to resin cement.</div></div><div><h3>Materials and methods</h3><div>Sixty-four 3Y-TZP discs were prepared, and subsequently, categorized into four distinct groups based on the conditioning regimen (<em>n</em> = 16): Group 1 (SB), Group 2 (ECL), Group 3 (YFL), and Group 4 (LLLT-RB). The Ra assessment was performed on five samples from each group using a profilometer. One specimen from each group was subjected to surface topography analysis under a scanning electron microscope (SEM). A self-adhesive resin cement was built on ten samples from each group and photo polymerized, followed by artificial ageing. The SBS and failure modes were assessed using a universal testing machine and a stereomicroscope, respectively. The data was evaluated using ANOVA and a post hoc test, <em>p</em> = 0.05.</div></div><div><h3>Results</h3><div>Samples surface treated with YFL attained the highest Ra scores (1334.32 ± 0.065 µm) and highest bond strength (9.34±0.29 MPa). In contrast, the 3Y-TZP discs surface treated with LLLT-RB exhibited the lowest Ra value (870.56 ± 0.076 µm) and the lowest bond values (5.76±0.34 MPa). Zirconia disc surface treated with ECL and SB groups demonstrated admixed failures. LLLT (RB), on the other hand, exhibited adhesive fractures with the highest frequency.</div></div><div><h3>Conclusion</h3><div>Ytterbium fiber laser displayed the most satisfactory performance in terms of improving surface roughness and shear bond strength of zirconia with the resin cement, and can be used as an alternative surface pretreating regime for zirconia.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 104784"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monte Carlo-based estimation of NIR-PDT efficacy with and without breast compression in early-stage breast cancer","authors":"Yugo Minegishi,&nbsp;Yasutomo Nomura","doi":"10.1016/j.pdpdt.2025.105330","DOIUrl":"10.1016/j.pdpdt.2025.105330","url":null,"abstract":"<div><h3>Introduction</h3><div>Near-infrared photodynamic therapy (NIR-PDT) for early-stage breast cancer has attracted attention and it suggests that the depth of the tumor from the skin surface significantly affects treatment efficacy, with shallower tumors responding more effectively to therapy. Therefore, compressing the breast, as is done during mammography, may improve therapeutic outcomes by reducing tumor depth. In this study, we investigated the effectiveness of breast compression in NIR-PDT for early-stage breast cancer using Monte Carlo simulations.</div></div><div><h3>Methods</h3><div>We evaluated the impact of breast compression on the effectiveness of NIR-PDT for early-stage breast cancer through Monte Carlo simulations. Sixty pairs of digital breast phantoms representing uncompressed and compressed states were generated, and spherical tumors with a 7 mm diameter were embedded under appropriate conditions in 15 of these pairs. The propagation of excitation light at an intensity of 330 mW/cm², a level considered safe for skin tissue, was then analyzed. Based on the computed excitation fluence, the corresponding amount of singlet oxygen produced was estimated to assess NIR-PDT efficacy.</div></div><div><h3>Results</h3><div>The simulations indicated that breast compression substantially reduced tumor depth, with an average decrease of 5 mm across the 15 pairs. Consequently, the number of irradiation sessions required for complete treatment was reduced by an average of 19. In 8 of the 15 phantoms, the number of treatment irradiation cycles was reduced to five or fewer, suggesting clinical feasibility.</div></div><div><h3>Conclusion</h3><div>These results demonstrate that applying appropriate breast compression can enhance the therapeutic performance of NIR-PDT for early-stage breast cancer.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105330"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction or early detection? Clarifying ectasia ML models","authors":"Henry Bair","doi":"10.1016/j.pdpdt.2026.105335","DOIUrl":"10.1016/j.pdpdt.2026.105335","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105335"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphologic and functional assessment of photoreceptors in anisometropic amblyopia using adaptive optics scanning laser ophthalmoscopy","authors":"Hang Yang ,&nbsp;Maoxia Lv ,&nbsp;Jie Peng,&nbsp;Qian Luo,&nbsp;Zhengzheng Wu,&nbsp;Tong Yan,&nbsp;Yanxi Xie,&nbsp;Jing Li,&nbsp;Yin Yang,&nbsp;Lin Zhou","doi":"10.1016/j.pdpdt.2025.105241","DOIUrl":"10.1016/j.pdpdt.2025.105241","url":null,"abstract":"<div><h3>Objective</h3><div>Using adaptive optics scanning laser ophthalmoscopy (AO-SLO) to investigate the cone photoreceptor structure in children with anisometropic amblyopia and to examine its correlation with contrast sensitivity function (CSF).</div></div><div><h3>Methods</h3><div>Fifteen patients with monocular anisometropic amblyopia (amblyopic eyes, AE; fellow eyes, FE) and 15 age-matched controls (normal eyes, NE) were enrolled (45 eyes). Data on macular cone photoreceptor density, spacing, and regularity; retinal and choroidal thickness; superficial capillary plexus vessel density (SCP-VD); choroidal vascularity index (CVI); and contrast sensitivity function (CSF) were collected. Statistical analyses were performed using one-way analysis of variance (ANOVA), Pearson correlation, and multivariate linear regression.</div></div><div><h3>Results</h3><div>Compared to the FE and NE groups, the AE group showed significantly reduced cone density (28,519.12 ± 2853.41 vs. 35,529.21 ± 2217.35 and 36,181.62 ± 3081.95 cells/mm², <em>P</em> &lt; 0.01), increased spacing (6.36 ± 1.64 vs. 4.22 ± 0.41 vs. 4.13 ± 0.50 μm, <em>P</em> &lt; 0.01), and decreased regularity (92.99 ± 1.49 % vs. 95.86 ± 1.20 % vs. 95.90 ± 1.03 %; <em>P</em> &lt; 0.01). The Area Under the Log Contrast Sensitivity Function (AULCSF) of the AE group (1.61 ± 0.08) was significantly lower than that of the FE (1.84 ± 0.04) and NE groups (1.87 ± 0.08; <em>P</em> &lt; 0.01). CSF was positively correlated with cone density (<em>R²</em> = 0.899, <em>P</em> &lt; 0.001) and regularity (<em>R²</em> = 0.530, <em>P</em> = 0.002) and negatively correlated with cone spacing (<em>R²</em> = 0.539, <em>P</em> = 0.002). Multivariate regression analysis revealed that cone density (<em>β</em> = 0.701, <em>P</em> &lt; 0.001) and cone regularity (<em>β</em> = 0.228, <em>P</em> = 0.026) had a positive predictive effect on AULCSF.</div></div><div><h3>Conclusion</h3><div>Anisometropic amblyopia shows disrupted macular cone structure, including reduced density and irregular spacing, which closely relates to impaired contrast sensitivity. AO-SLO can help assess these retinal deficits in developmental visual disorders.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105241"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OCT-based retinal biomarkers forecast central nervous system structural decline in Parkinson’s disease: A longitudinal multimodal study within the Persian Cohort","authors":"Farzane Nikparast ,&nbsp;Nooshin Akbari-Sharak ,&nbsp;Zohreh Ganji ,&nbsp;Ali Shoeibi ,&nbsp;Naser Shoeibi ,&nbsp;Hoda Zare","doi":"10.1016/j.pdpdt.2025.105310","DOIUrl":"10.1016/j.pdpdt.2025.105310","url":null,"abstract":"<div><h3>Background and Objective</h3><div>Parkinson's disease (PD) is among the most prevalent progressive neurodegenerative disorders, impacting both the central and peripheral nervous systems.This longitudinal study investigates whether structural changes in the retina, due to its developmental and structural similarities with the brain, can act as early indicators of brain alterations in patients with PD.</div></div><div><h3>Methods</h3><div>Data from 29 PD patients and 25 healthy controls were analyzed. After a mean interval of 2.7 years after retina imaging, all participants underwent a 1.5T magnetic resonance imaging (MRI) Scan. Image processing was performed using 3D Slicer and the CAT12 toolbox, while statistical analyses were conducted with R software.</div></div><div><h3>Results</h3><div>In healthy controls, a significant positive correlation was observed between gray and white matter volumes and peripapillary retinal nerve fiber layer (pRNFL) thickness (r = 0.5, p &lt; 0.05) and (r = 0.4, p &lt; 0.05). In contrast, PD patients showed a significant association between increased CSF volume and reduced pRNFL thickness and optic nerve rim volume (r = -0.50 to -0.40; p &lt; 0.05) and (r = -0.50; p &lt; 0.05), respectively. Moreover, neuromelanin signal intensity in the substantia nigra correlated positively and significantly with pRNFL thickness in nasal and superior sectors exclusively in the PD group (r = 0.40 to 0.60; p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Retinal alterations in PD are closely aligned with concurrent brain neurodegeneration and may serve as predictive biomarkers. These findings suggest that OCT, when combined with MRI, may support a non-invasive strategy for early risk stratification and longitudinal monitoring of PD.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105310"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}