中枢浆液性脉络膜视网膜病变OCT-A图像的分形分析。

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-05-23 DOI:10.1016/j.pdpdt.2025.104642

Arturo Carta , Angelique Donnio , Stefano Dore , Maurizio Fossarello , Roberta Farci

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引用次数: 0

摘要

目的：应用分形分析方法对中枢性浆液性绒毛膜视网膜病变（CSC）患者的OCT-A绒毛膜毛细血管层（CCL）图像进行分析。设计：病例对照研究。参与者：用OCT-A分析16例CSC患者的17只眼睛，并依次与8例健康患者的14只眼睛进行比较。方法：在Image J软件（https://imagej.nih.gov/NIH, Bethesda， MD， USA）中打开OCT-A图像。采用骨架化处理，随后进行分形分析。随后，利用FracLac插件实现了分形分析：使用多重分形工具。然后将数据导入Excel电子表格进行统计分析。对病例和对照进行独立t检验。在病例和对照组之间，以及分形值和参与者性别之间，还应用了曼-惠特尼检验；分形变量与年龄、视力分别进行Spearman检验。结果：病例的平均分形维数（FD）为1.96±0.010；对照组平均FD为1.86±0.02。学生t检验显示病例与对照组之间存在显著差异（p= 0.052）。差异有统计学意义（p0.519）。男性和女性之间无显著差异（p=0,245）。结论：分形分析是一种新的、可替代的评价CSC视网膜影像学的方法，可对该视网膜疾病进行新的评价。

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Fractal analysis for OCT-A images of central serous chorioretinopathy

Objective

to analyze OCT-A choriocapillary layer (CCL) images of patients affected by central serous chorioretinopathy (CSC) by means of fractal analysis.

Design

a case-control study.

Participants

17 eyes of 16 patients affected by CSC were analyzed with OCT-A, and, successively, compared to 14 eyes of 8 healthy patients.

Methods

OCT-A images were opened in Image J software (https://imagej.nih.gov/NIH, Bethesda, MD, USA). Skeletonization process was applied, and subsequently, a fractal analysis was performed. Thereafter, fractal analysis by means of FracLac plugin was also realized: multifractal tool was applied. Data were then imported into Excel spreadsheet for statistical analysis. An independent t-Test between cases and controls was performed. A Mann-Whitney test between cases and controls, and between fractal values and sex of the participants was also applied; Spearman test was realized between fractal variables and the age and the visual acuity, respectively.

Results

mean fractal dimension (FD) of cases was 1,96±0,010; mean FD of controls was 1,86±0,02. Student t-test showed a significant difference between cases and controls (p=0,052). A statistically significant (p<0.05) correlation between visual acuity and mean FD (rho=0.519, p=0,033) was found. No significant correlation between age and the mean FD was found (p>0.519). No significant difference between males and females was found (p=0,245).

Conclusions

fractal analysis is a new, alternative method to evaluate retinal imaging in CSC, which can make a new assessment of this retinal disease.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.