Photodiagnosis and Photodynamic Therapy最新文献

{"title":"A comparison of repeated low-level red light and low-dose atropine for myopia control: A two-year retrospective study","authors":"Mingming Zhang ,&nbsp;Yinghui Shi ,&nbsp;Yuexin Wang ,&nbsp;Yangguang Li ,&nbsp;Jian Qin ,&nbsp;Xiaobing Wang ,&nbsp;Ying Jie","doi":"10.1016/j.pdpdt.2025.104754","DOIUrl":"10.1016/j.pdpdt.2025.104754","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the long-term efficacy between repeated low-level red light (RLRL) therapy and low-dose atropine (LDA) eye drops for myopia control.</div></div><div><h3>Methods</h3><div>Treatment naïve myopic children receiving RLRL or LDA therapy were retrospectively included. The spherical equivalent (SE) and axial length (AL) were evaluated at baseline and 6-, 12-, and 24-month follow-up. The myopia progression and regression were compared between groups.</div></div><div><h3>Results</h3><div>In total, 122 myopic children were enrolled. The SE progression and AL elongation were significantly less in the RLRL than in the LDA group at 6 months (<em>P</em> = 0.002, SE; <em>P</em> = 0.004, AL), 12 months (<em>P</em> &lt; 0.001) and 24 months (<em>P</em> &lt; 0.001). For patients with RLRL, the SE progression was greater during the second than the first year (<em>P</em> = 0.05). The proportion of patients with SE regression in the RLRL group was greater than that in the LDA group at 12 months (<em>P</em> = 0.003), and the AL shortening proportion was significantly greater in the RLRL group than in the LDA group at 6 months (<em>P</em> = 0.001), 12 months (<em>P</em> = 0.001), and 24 months (<em>P</em> = 0.049). Eight adverse events were reported in the RLRL group without irreversible structural damage.</div></div><div><h3>Conclusion</h3><div>The present research demonstrates that RLRL treatment is more effective than 0.01 % atropine in delaying myopia progression and observes a greater percentage of patients with SE regression and AL shortening in myopic children over two years.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104754"},"PeriodicalIF":2.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive use of photodynamic therapy in refractory cutaneous granuloma caused by Mycobacterium marinum infection: A case report","authors":"Mao Li ,&nbsp;Li Song ,&nbsp;Yalin Zhang ,&nbsp;Jiaojiao Pei ,&nbsp;Mao Lu","doi":"10.1016/j.pdpdt.2025.104753","DOIUrl":"10.1016/j.pdpdt.2025.104753","url":null,"abstract":"<div><div>Mycobacterium marinum is a major species of nontuberculous mycobacteria (NTM) responsible for skin infections, commonly affecting aquatic animals and humans. The typical histopathological pattern of cutaneous M. marinum infection is suppurative granuloma. Antibiotics are the first-line treatment; however, they often require prolonged courses, are associated with significant side effects, and carry a risk of drug resistance. Aminolevulinic acid photodynamic therapy (ALA-PDT) represents a safe and effective therapeutic option for cutaneous M. marinum infections, particularly in drug-resistant cases. This report describes a patient with cutaneous granuloma caused by M. marinum infection who showed no significant improvement after two months of oral triple-antibiotic therapy. Subsequently, while continuing oral antibiotics, the patient underwent ALA-PDT once weekly for 4 consecutive weeks. Following four treatment sessions, the nodules, plaques, and ulcers on both the wrist and forearm were completely eradicated, with no recurrence observed during the 6-month follow-up period. This case suggests that adjunctive ALA-PDT, acting locally, can potentially reduce treatment duration and minimize systemic antibiotic-related side effects and adverse reactions, offering a valuable alternative for patients with suboptimal responses to antibiotic therapy alone.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104753"},"PeriodicalIF":2.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144801333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cordycepin potentiates photodynamic therapy efficacy in esophageal cancer cells via Modulation of the PI3K/AKT/FOXO3 signaling pathway","authors":"Ming Zhang ,&nbsp;Ying Wang ,&nbsp;Zhenhua Sun ,&nbsp;Yingqian Ma ,&nbsp;Lin Zou ,&nbsp;Juan Li ,&nbsp;Pintian Lv","doi":"10.1016/j.pdpdt.2025.104725","DOIUrl":"10.1016/j.pdpdt.2025.104725","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) has been approved for the treatment of esophageal cancer (EC), but its effectiveness remains limited. Emerging evidence suggests that cordycepin can synergize with other therapeutic modalities. Therefore, we investigated whether the combination of PDT and cordycepin could enhance the therapeutic efficacy. Using colony formation assay and flow cytometry, we assessed the effects of the viability and apoptosis on EC cells. RT-qPCR and Western blot analyses were employed to examine the expression of pathway-related proteins and genes. In vitro, results demonstrated that the combination of PDT and cordycepin enhanced apoptosis to inhibit cell growth and increased the production of immune factors IL-18 and IL-1β. Furthermore, it inhibited the expression levels of p-PI3K/PI3K, p-AKT/AKT, and Bcl-2, while enhancing the expression levels of FOXO3, Caspase-3, Bax, Caspase-9, and Cyt-C. In conclusion, PDT combined with cordycepin enhances the anti-cancer effect through the PI3K/AKT/FOXO3 signaling pathway in EC cells. The experiment provides a theoretical basis for the combination of PDT and cordycepin to become a new strategy which may increase the efficacy of PDT in esophageal cancer.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104725"},"PeriodicalIF":2.6,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144791064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical fogging is an effective method of reducing overestimation of myopia","authors":"Jiajia Lin ,&nbsp;Ting Chen ,&nbsp;Zequn Lin ,&nbsp;Xinyao Xiong ,&nbsp;Yinhe Chen ,&nbsp;Yang Yu ,&nbsp;Luoming Huang","doi":"10.1016/j.pdpdt.2025.104751","DOIUrl":"10.1016/j.pdpdt.2025.104751","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate the effectiveness of optical fogging in controlling accommodation and to evaluate its efficiency in reducing myopic overestimation among young adults, with the goal of providing scientific evidence for clinical refractive measurement.</div></div><div><h3>Methods</h3><div>A total of 142 young adults aged 17 to 23 years (284 eyes) were enrolled. Refractive status and ocular biometric parameters were measured using open-field autorefractor and partial coherence interferometry under three conditions: baseline, optical fogging, and cycloplegia. Optical fogging was induced by wearing +2.00 D spherical lenses for 20 min, while cycloplegia was induced using 0.5 % compound tropicamide-phenylephrine eye drops. Eyes were categorized into overestimated and non-overestimated myopia groups based on whether the difference in spherical equivalent (SE) between cycloplegic and baseline measurements was ≥0.50 D. Changes in SE and lens thickness under the three conditions were analyzed, and the efficiency of optical fogging-induced accommodative control was calculated.</div></div><div><h3>Results</h3><div>In the overestimated myopia group (82 eyes), optical fogging reduced accommodation by an average of 0.28 ± 0.37 D compared to baseline (<em>p</em> &lt; 0.001), accounting for 36.84 % of the effect of cycloplegia (0.76 ± 0.29 D). In the total sample eyes, optical fogging reduced accommodation by 0.07 ± 0.34 D (<em>p</em> &lt; 0.001), which corresponded to 21.88 % of the cycloplegic effect (0.32 ± 0.37 D). Lens thickness showed no significant change after optical fogging (all <em>p &gt; 0.05</em>).</div></div><div><h3>Conclusions</h3><div>Optical fogging effectively suppresses unnecessary accommodative responses in young adults, significantly reducing myopic overestimation, with particularly pronounced effects in those with notable myopic overestimation. Although optical fogging is less effective than cycloplegia in relaxing accommodation, it offers advantages in terms of ease of use, non-invasiveness, and good tolerance, making it highly applicable in clinical refractive measurement.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104751"},"PeriodicalIF":2.6,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pitfalls and other issues with the MTT assay","authors":"David Kessel","doi":"10.1016/j.pdpdt.2025.104700","DOIUrl":"10.1016/j.pdpdt.2025.104700","url":null,"abstract":"<div><div>While the colorimetric assay commonly referred to as ‘MTT’ does provide an indication of effects of photodamage on mitochondrial enzyme levels, a careful analysis showed that the resulting data were not correlated with a clonogenic assay. While MTT data can be claimed to represent ‘cytotoxicity’, this is an undefined term and appears not to be necessarily correlated with the object of anti-tumor therapy: tumor eradication. Use of this assay for assessing effects of treatment on viability are therefore unreliable.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104700"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Nitrogen-doped carbon dots/curcumin nanocomposite for combined Photodynamic/photothermal dual-mode antibacterial therapy” [Photodiagnosis and Photodynamic Therapy, 39 (2022) 103033]","authors":"Fangzhou Wen ,&nbsp;Peiyuan Li ,&nbsp;Hongrong Meng ,&nbsp;Hongjun Yan ,&nbsp;Xiaodong Huang ,&nbsp;Hao Cui ,&nbsp;Wei Su","doi":"10.1016/j.pdpdt.2025.104688","DOIUrl":"10.1016/j.pdpdt.2025.104688","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104688"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Halofuginone enhances the anti-tumor effect of ALA-PDT by suppressing NRF2 signaling in cSCC” [Photodiagnosis and Photodynamic Therapy. 37 (2022) 102572]","authors":"Ting Lv ,&nbsp;Jianhua Huang ,&nbsp;Minfeng Wu ,&nbsp;Hongwei Wang ,&nbsp;Qingyu Zeng ,&nbsp;Xiuli Wang","doi":"10.1016/j.pdpdt.2025.104657","DOIUrl":"10.1016/j.pdpdt.2025.104657","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104657"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repair strength and roughness of resin matrix ceramic pretreated with rose bengal activated low level laser therapy and Er, Cr: YSGG bonded to different viscosity composites","authors":"Khulud A. Al Aali","doi":"10.1016/j.pdpdt.2025.104740","DOIUrl":"10.1016/j.pdpdt.2025.104740","url":null,"abstract":"<div><div><strong>AIM</strong>: Assessment of the effectiveness of various pre-treatment techniques, i.e., Airborne particle abrasion (APA), Er, Cr: YSGG lasers (ECL), Rose Bengal (RB) activated via Low-level laser therapy (LLLT) on the repair bond strength (RBS) of resin matrix ceramics (RMC) bonded with different viscosity composites.</div><div><strong>MATERIALS AND METHODS</strong>: RMC blocks were meticulously cut into 78 discs. All the discs were then randomly assigned to three separate groups based on the conditioning regime(<em>n</em> = 26): Group 1 (APA), Group 2 (ECL), and Group 3 (LLLT-RB). Five samples from each category were selected at random to assess Ra(<em>n</em> = 5). One prepared sample from each group underwent surface topography analysis and energy dispersive X-ray analysis (EDX) (<em>n</em> = 1). Each group was further categorized into two subgroups based on the type of composite resin used(<em>n</em> = 10). High viscosity micro-hybrid composite (A) and a low viscosity injectable composite (B) followed by artificial aging<strong><em>.</em></strong> RBS and failure mode were analyzed using a universal testing machine and stereomicroscope. The Ra and RBS data underwent comparison through a two-way ANOVA and post hoc Tukey test (p˂0.05).</div><div><strong>RESULTS</strong>: The maximum Ra was exhibited by Group 2 (ECL) (1056.65 ± 0.029 µm) discs. Conversely, Group 3 (LLLT-RB) (753.31 ± 0.045 µm) conditioned samples demonstrated the minimum Ra. The highest bond strength score was recorded by Group 2B (ECL + Injectable) (10.63±0.19 MPa). In contrast, the lowest average bond strength value was noted in Group 3A (LLLT-RB + Microhybrid) (7.99±0.77 MPa).</div><div><strong>CONCLUSION</strong>: ECL has the potential to serve as a hybrid ceramic surface conditioner, as it improves the surface roughness scores. Furthermore, low-viscosity injectable composites showed better performance than high-viscosity composites in achieving higher bond strength.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104740"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of photodynamic therapy combined with CO2 laser in the treatment of vulvar squamous intraepithelial lesions","authors":"Jingyi Mu ,&nbsp;Yunfeng Zhang ,&nbsp;Guiqin Chen ,&nbsp;Yongjie Li ,&nbsp;Yue Wang","doi":"10.1016/j.pdpdt.2025.104744","DOIUrl":"10.1016/j.pdpdt.2025.104744","url":null,"abstract":"<div><h3>Background</h3><div>Comprehensive research data on the combination of 5-aminolevulinic acid (5-ALA) photodynamic therapy (PDT) and CO₂ laser treatment in the management of vulvar squamous intraepithelial lesions (VSIL) remains limited. This study evaluates the efficacy and adverse reactions associated with the combination treatment for VSIL.</div></div><div><h3>Methods</h3><div>This study was a retrospective study. The subjects were 165 patients diagnosed with VSIL in the People’s Hospital of Zhengzhou University. According to the patients’ personal choice, they were divided into 5-ALA PDT group (<em>n</em> = 37), CO2 laser group (<em>n</em> = 78) and 5-ALA PDT combined with CO2 laser group (<em>n</em> = 50). The general condition, treatment times and adverse reactions of patients in each group were analyzed. All patients underwent HPV, TCT and colposcopy at 3 months and 6 months after treatment to evaluate the therapeutic effect, and biopsy was performed again if necessary.</div></div><div><h3>Results</h3><div>There was no statistically significant difference in the HPV negative conversion rates and lesions complete remission (CR) rates of both vulvar low-grade squamous intraepithelial lesions (VLSIL) and vulvar high-grade squamous intraepithelial lesions (VHSIL) patients among the three groups at 3 months after treatment. Regarding VLSIL, the HPV negative conversion rates for both the 5-ALA PDT group (51.7 %) and the combination group (51.9 %) were significantly higher than the CO₂ laser group (27.6 %) at six months post-treatment. Regarding VHSIL, the HPV negative conversion rates for the 5-ALA PDT group (62.5 %) and the combination group (60.9 %) were significantly higher than the CO₂ laser group (25.0 %) at 6 months post-treatment. However, recurrence rates did not differ significantly among the three groups. The combination group required fewer treatment sessions compared to the single treatment groups. The CO₂ laser group experienced the mildest adverse reactions, followed by the combined treatment group, while the 5-ALA PDT group exhibited more pronounced reactions.</div></div><div><h3>Conclusion</h3><div>The integration of 5-ALA PDT with CO₂ laser therapy not only reduces the overall treatment duration but also enhances treatment efficacy. Therefore, it is a promising option for treating VSIL.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104744"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precise diagnosis of small cell and non-small cell lung cancer based on Raman spectroscopy","authors":"Wendong Sun ,&nbsp;Liwei Liao ,&nbsp;Ruochen Zhu ,&nbsp;Yuexiang Wang ,&nbsp;Keren Chen ,&nbsp;Gang Hou ,&nbsp;Shuo Chen","doi":"10.1016/j.pdpdt.2025.104747","DOIUrl":"10.1016/j.pdpdt.2025.104747","url":null,"abstract":"<div><div>Lung cancer has been the second most prevalent cancer globally and the leading cause of cancer-related mortality. Due to the similar clinical symptoms but different treatment protocols for different subtypes of lung cancer, precise diagnosis between small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) is of paramount importance for guiding treatment and improving outcomes. In this study, we explored an innovative diagnostic approach that combines Raman spectroscopy with partial least squares analysis and linear discriminant analysis (PLS-LDA) to identify the presence of lung cancer and differentiate its specific subtype. Based on biochemical analysis results, statistically significant differences between SCLC and NSCLC groups were observed in levels of amino acids, nucleic acids, and collagen. In addition, high diagnostic accuracy rates of up to 100 % for in vitro cultured cell samples and 93.75 % for ex-vivo tissue samples were achieved to differentiate SCLC and NSCLC. The proposed method offers great potential in the precise diagnosis of lung cancer with different histologic subtypes, benefiting timely and rational treatment for lung cancer patients.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104747"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}