Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Reply to letter to the editor: Photodiagnosis of diabetic eye disease–the Beichen eye study","authors":"Luxi Li, Juping Liu , Xiaorong Li","doi":"10.1016/j.pdpdt.2025.104520","DOIUrl":"10.1016/j.pdpdt.2025.104520","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104520"},"PeriodicalIF":3.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved analysis with spectral-domain optical coherence tomography angiography for evaluating vascular damage in exfoliation syndrome","authors":"Rongpei Zhang ,&nbsp;Bingying Lin ,&nbsp;Hairui Zhang ,&nbsp;Yuncheng Ma ,&nbsp;Na Xu ,&nbsp;Ling Jin ,&nbsp;Zhenyu Wang ,&nbsp;Lei Tian ,&nbsp;Munire Mohetaer ,&nbsp;Aizezi Wumaier ,&nbsp;Rongxin Chen ,&nbsp;Danping Huang","doi":"10.1016/j.pdpdt.2025.104504","DOIUrl":"10.1016/j.pdpdt.2025.104504","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess microvascular damage in exfoliation syndrome (XFS) patients with spectral-domain optical coherence tomography (OCT) and the correlations between OCT angiography (OCTA) parameters and systemic blood parameters in XFS.</div></div><div><h3>Methods</h3><div>Twenty-one XFS eyes and 23 healthy eyes were included in this cross-sectional study. The foveal avascular zone (FAZ) area, vessel density (VD), thickness of the layers of the ganglion cell complex (GCC), homocysteine (Hcy) level, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were compared between the two groups. The correlations between OCTA parameters and systemic blood parameters were analyzed. Receiver operating characteristic curve analysis was performed to evaluate the ability of the OCTA parameters to predict XFS.</div></div><div><h3>Results</h3><div>Compared with healthy controls, XFS patients had an enlarged FAZ area and a lower VD in the superficial vascular complex (SVC). The GCL thickness map and VD map of the SVC and deep vascular complex (DVC) revealed the presence of pathological damage at the outer superior (OS) and outer inferior (OI) sectors in XFS patients. In XFS patient, the FAZ area and OS VD of the SVC were strongly correlated with the Hcy levels, and the OS VD of the SVC was significantly negatively correlated with the NLR and PLR. The areas under the receiver operating characteristic curve for the SVC FAZ area and OS VD in predicting XFS were both &gt;0.67.</div></div><div><h3>Conclusions</h3><div>The pixel-level FAZ algorithm and VD map derived from OCTA can reflect microvascular damage in XFS. The fundus lesions observed in XFS are accompanied by systemic circulatory changes.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104504"},"PeriodicalIF":3.1,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cone mosaic in eyes with varied axial length using adaptive optics scanning laser ophthalmoscopy","authors":"Wen-Da Zhou ,&nbsp;Li Dong ,&nbsp;Han-Xu Shi,&nbsp;Rui-Heng Zhang,&nbsp;Yu-hang Yang,&nbsp;Han-qing Zhao,&nbsp;Yi-Tong Li,&nbsp;Chu-Yao Yu,&nbsp;He-Yan Li,&nbsp;Hao-Tian Wu,&nbsp;Lei Shao,&nbsp;Wen-Bin Wei","doi":"10.1016/j.pdpdt.2025.104517","DOIUrl":"10.1016/j.pdpdt.2025.104517","url":null,"abstract":"<div><h3>Background</h3><div>Abnormalities in cone photoreceptor topography are closely associated with the development of various ocular diseases, including axial myopia. Adaptive Optics Scanning Laser Ophthalmoscopy (AOSLO) enables high-resolution, single-cell imaging of the living human retina.</div></div><div><h3>Methods</h3><div>This study aimed to investigate the potential relationship between cone topography and axial myopia using a commercial AOSLO system. A total of 74 participants (148 eyes; 30 men, 40.5 %) with a mean age of 31.8 ± 10.4 years were included. Cone mosaics were imaged at 3° and 5° eccentricities of the fovea centralis. The relationships between cone parameters (linear cone density, cone spacing, cone dispersion, and cone regularity) and axial length were analyzed.</div></div><div><h3>Results</h3><div>Linear cone density significantly decreased with increasing axial length at both 3° and 5° eccentricities (all <em>P</em> &lt; 0.001). Cone spacing significantly increased with greater axial length and reduced cone density. After adjusting for axial length, cone spacing was significantly associated only with linear cone density at both 3° and 5° eccentricities (all <em>P</em> &lt; 0.001). Cone dispersion significantly increased with longer axial length and lower cone density. After adjusting for axial length, cone dispersion remained significantly associated with linear cone density only at the inferior 3° (<em>β</em> = -0.43, <em>P</em> = 0.014) and inferior 5° eccentricities (<em>β</em>=-0.4, <em>P</em> = 0.003). Cone regularity significantly increased with higher linear cone density at certain 3° eccentricities (nasal: <em>β</em>=0.34, <em>P</em> &lt; 0.001; temporal: <em>β</em>=0.25, <em>P</em> = 0.006; inferior: <em>β</em> = 0.2, <em>P</em> = 0.04) and significantly decreased with longer axial length at temporal 5° eccentricity (<em>β</em> = -0.57, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Linear cone density was significantly reduced in axial myopia. The uniformity of cone distribution was disrupted as a result of the reduction in cone density. Additionally, cone regularity was significantly diminished in axial myopia, potentially due to the direct effects of axial elongation at 5° eccentricity or reductions in cone density at 3° eccentricity.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104517"},"PeriodicalIF":3.1,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of low-level laser therapy in patients with maxillofacial neuropathies. A systematic review of randomized controlled trials","authors":"Leonardo Díaz ,&nbsp;Javier Basualdo ,&nbsp;Alain Chaple-Gil ,&nbsp;Alfredo Von Marttens ,&nbsp;Eduardo Fernández","doi":"10.1016/j.pdpdt.2025.104516","DOIUrl":"10.1016/j.pdpdt.2025.104516","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the effectiveness and safety of low-level laser therapy (LLLT) in managing maxillofacial neuropathies, with a focus on pain reduction, neurological recovery, and tissue regeneration.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed, Web of Science, Scopus, and EBSCO databases was conducted for English-, Spanish-, and Portuguese-language publications on LLLT for maxillofacial neuropathies up to December 2024. Randomized controlled trials (RCTs) involving patients with paresthesia, neuralgia, or facial paralysis treated with LLLT were included. Data extraction and risk-of-bias assessments were conducted by two independent reviewers, and results were synthesized qualitatively and quantitatively.</div></div><div><h3>Results</h3><div>From an initial pool of 841 studies, 18 RCTs involving 1,220 patients met the inclusion criteria. LLLT significantly reduced pain scores on the Visual Analog Scale (VAS) (mean reduction = –3.5, 95 % CI:4.2 to –2.8, P &lt; 0.001) and facilitated a 45 % faster recovery of sensory thresholds compared to controls (P &lt; 0.001). Tissue regeneration markers, including collagen deposition and epithelialization rates, improved, resulting in a 25 % reduction in healing times (P &lt; 0.05). Mild adverse events, such as transient erythema, were reported in &lt;5 % of cases. Variability in laser dosimetry and small sample sizes across studies were noted.</div></div><div><h3>Conclusion</h3><div>Low-level laser therapy is an effective and safe modality for managing maxillofacial neuropathies, demonstrating significant benefits in pain reduction, nerve recovery, and tissue healing. Standardized protocols and multicenter trials are necessary to optimize its application.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104516"},"PeriodicalIF":3.1,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancement of activity in the Cancer immune system due to the presence of microcomponents when Exposed to Photodynamic: An in Vitro Experiment","authors":"Barbara M. Kukiełczak Detweiler ,&nbsp;Amanda C. Zangirolami ,&nbsp;Gus A. Wright ,&nbsp;Da M. Kim ,&nbsp;Vanderlei S. Bagnato","doi":"10.1016/j.pdpdt.2025.104518","DOIUrl":"10.1016/j.pdpdt.2025.104518","url":null,"abstract":"<div><div>The application of photodynamic therapy (PDT) has aimed at destroying tumor cells and microbiological control in infections. Experimentation <em>in vitro</em> with individual elements of a biological system enables the study of mechanism of action and provides directions to <em>in vivo</em> applications where cancer coexists with normal cells and microorganisms, whether opportunistic or not. The action of the combined set of elements leads to a different behavior from each of the components isolated. In this study, we created a simple model to investigate the effects of PDT (1) on the coculture of macrophages (2) and melanoma cells (3) infected with <em>E. coli</em> (4) under different combinations. Comparing the 4 individual elements of the system interacting with each other to all of them interacting together, we found that macrophage phagocytosis depends on the order in which the elements are exposed to PDT. That indicates the behavior of macrophages depends on their relationship with the microenvironment. Applying the photodynamic effect to each component separately or to all of them together results in different outcomes. These <em>in vitro</em> experiments provide pathways to understand or to design new and more efficient applications of PDT.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104518"},"PeriodicalIF":3.1,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of toric intraocular lens implantation in individuals with cataracts and asymmetric corneal astigmatism","authors":"Jiezheng Xue ,&nbsp;Anpeng Pan ,&nbsp;Xu Shao ,&nbsp;Xu Xu","doi":"10.1016/j.pdpdt.2025.104515","DOIUrl":"10.1016/j.pdpdt.2025.104515","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study is to evaluate the efficacy and safety of toric intraocular lens (IOL) implantation in individuals with cataracts and asymmetric corneal astigmatism and to assess their postoperative visual quality.</div></div><div><h3>Methods</h3><div>In this prospective case series, 26 eyes of individuals with cataracts and corneal astigmatism &gt; 0.75 diopters (D) and asymmetric central astigmatism as identified through corneal topography were examined at the Eye Hospital of Wenzhou Medical University, China. All participants underwent toric IOL implantation surgery at the hospital. The primary outcome measures included uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), residual astigmatism, prediction error, and the degree of IOL rotation.</div></div><div><h3>Results</h3><div>Both postoperative UCVA and BCVA improved significantly, with UCVA increasing from 0.70 (0.40, 0.93) to 0.018 (0.05, 0.30) logMAR, and BCVA improving from 0.50 (0.38, 0.70) to 0.00 (0.0, 0.10) logMAR (P &lt; 0.001). A strong positive correlation was observed between the preoperative predicted spherical equivalent and the postoperative actual spherical equivalent (= 0.7682), with prediction errors for the spherical equivalent within ± 1.00 D in all cases. Postoperative residual astigmatism was ≤ 1.00 D in 25 eyes (96%), and the mean degree of toric IOL rotation was 2.46° ± 2.08°. Objective assessments of visual quality showed that patients with asymmetric corneal astigmatism achieved better postoperative visual quality under miotic conditions (pupil diameter: 2 mm), with a significant decrease in visual quality as pupil diameter increased.</div></div><div><h3>Conclusion</h3><div>The results of this study demonstrated that toric IOL implantation surgery is an effective and safe treatment for selected individuals with cataracts and asymmetric corneal astigmatism. Preoperative predictions for spherical equivalent and residual astigmatism in these patients proved accurate and reliable, resulting in favorable visual outcomes and enhanced visual quality post-surgery.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104515"},"PeriodicalIF":3.1,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of additional points in the 24-2C visual field test in pre-perimetric glaucoma","authors":"Gökhan Çelik ,&nbsp;Tuncay Karaçocuk ,&nbsp;Furkan Çiftci","doi":"10.1016/j.pdpdt.2025.104513","DOIUrl":"10.1016/j.pdpdt.2025.104513","url":null,"abstract":"<div><h3>Background</h3><div>Early detection and prevention of glaucoma progression are critical. However, studies of early visual field (VF) changes, particularly those using the 24-2C VF test, are limited. Evaluation of additional points in 2C may help identify glaucoma at an early stage, enabling timely intervention. Pre-perimetric glaucoma (PPG) is characterised by structural damage without noticeable VF loss in standard tests. Assessments of changes in retinal nerve fibre layer (RNFL) and macular ganglion cell complex (mGCC) thickness are valuable, but exploring how these structural changes are related to functional deficits is crucial.</div></div><div><h3>Objective</h3><div>This study focused on the average of the additional points in the 24-2C test to understand their correlation with structural measures in the PPG.</div></div><div><h3>Material and method</h3><div>This study included 59 patients with PPG and 36 healthy individuals. All the patients underwent peripapillary and macular optical coherence tomography (OCT) (Nidek RS-3000 Advance; Nidek, Japan). RNFL thickness was evaluated using peripapillary OCT, and mGCC thickness was evaluated using the macular OCT glaucoma module. The mean deviation (MD), pattern standard deviation (PSD), visual field index (VFI), and average of additional points in the 2C (AAP-2C) were evaluated using the 24-2C SITA Faster VF Humphrey Field Analyser III Model 850 (HFAIII; Zeiss Meditec, Dublin, CA, USA). The relationship between structural and functional parameters was statistically evaluated.</div></div><div><h3>Results</h3><div>The PPG group showed significantly lower RNFL and mGCC thickness values than the healthy group. The MD, PSD, and VFI did not differ significantly between the groups. For AAP-2C, the PPG group showed significantly lower sensitivity than healthy individuals. A statistically significant positive correlation between was observed between AAP-2C and mGCC thickness (<em>p</em> = 0.003, <em>r</em> = 0.385). However, the RNFL and mGCC thickness values showed no statistically significant correlations with the MD, PSD, and VFI.</div></div><div><h3>Conclusion</h3><div>Although no glaucomatous change was observed in the VF in patients with PPG, these patients showed reduced sensitivity of the additional points. The reduced sensitivity of the additional points in the 24-2C VF test may reflect early macular functional alterations that correlate with structural damage during the pre-perimetric period.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104513"},"PeriodicalIF":3.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights on antibacterial mode of action of blue-light photoactivated berberine and curcumin-antibiotic combinations against Staphylococcus aureus","authors":"Ariana S.C. Gonçalves ,&nbsp;José R. Fernandes ,&nbsp;Maria José Saavedra ,&nbsp;Nuno M. Guimarães ,&nbsp;Cristiana Pereira ,&nbsp;Manuel Simões ,&nbsp;Anabela Borges","doi":"10.1016/j.pdpdt.2025.104514","DOIUrl":"10.1016/j.pdpdt.2025.104514","url":null,"abstract":"<div><div>Antimicrobial photodynamic inactivation (aPDI), using photosensitisers in combination with antibiotics, is a promising multi-target strategy to address antibiotic resistance, particularly in wound infections. This study aimed to elucidate the antibacterial mode of action of combinations of berberine (Ber) or curcumin (Cur) with selected antibiotics (Ber-Ab or Cur-Ab) under blue light irradiation (420 nm) against <em>Staphylococcus aureus</em>, including methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) strains. Multiple physiological parameters were assessed using complementary assays (fluorometry, epifluorescence microscopy, flame emission and atomic absorption spectroscopy, zeta potential, flow cytometry, and the plate agar method) to examine the effect on ROS production, membrane integrity, DNA damage, motility and virulence factors of <em>S. aureus</em>. Results indicated that blue light photoactivated Ber-Ab and Cur-Ab combinations led to substantial ROS generation, even at low concentrations, causing oxidative stress that severely impacted bacterial membrane integrity (approximately 90 % in MRSA and 40 % in MSSA). Membrane destabilization was further confirmed by elevated intercellular potassium release (≈ 2.00 and 2.40 µg/mL in MRSA and MSSA, respectively). Furthermore, significant DNA damage was observed in both strains (≈ 50 %). aPDI treatment with blue light also reduced <em>S. aureus</em> pathogenicity by impairing motility and inhibiting key virulence factors such as proteases, lipases, and gelatinases, all of which play key roles in the infectious process. Overall, Ber-Ab combinations demonstrated the highest efficacy across all parameters tested, highlighting for the first time the multi-target therapeutic potential of this phytochemical-based aPDI strategy to combat antibiotic-resistant <em>S. aureus</em> infections and improve wound infection treatment outcomes.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104514"},"PeriodicalIF":3.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second harmonic generation-mediated Photodynamic Therapy for Staphylococcus aureus: A novel approach using Bismuth Ferrite-Protoporphyrin IX conjugates","authors":"Manu Kumar ,&nbsp;Avinash Jukanti ,&nbsp;Rivka Cahan ,&nbsp;Ariel Nause ,&nbsp;Refael Minnes","doi":"10.1016/j.pdpdt.2025.104512","DOIUrl":"10.1016/j.pdpdt.2025.104512","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) is a minimally invasive treatment modality that utilizes photosensitizing agents, light, and molecular oxygen to produce cytotoxic reactive oxygen species (ROS) to treat cancerous cells and bacterial infections. However, the effectiveness of PDT is often limited by the penetration depth of the light used to activate the photosensitizer (PS). We propose an effective method to address this challenge using Second Harmonic Generation (SHG), a nonlinear optical process in which two identical photons combine to form a new photon with double the frequency. This technique enables the utilization of longer wavelengths for enhanced tissue penetration, subsequently converting them into shorter wavelengths that align with the absorption characteristics of the photosensitizer. Thus, to achieve a highly effective production of SHG, we successfully synthesized the Harmonic Nanoparticle (HNP), Bismuth Ferrite (BFO). Subsequently, BFO was conjugated with Protoporphyrin IX (PPIX) to get BFO-PPIX conjugates for PDT treatment. These were exposed to Near Infrared (NIR) femtoseconds pulsed laser with a wavelength of 798 nm. PDT experiments using BFO-PPIX conjugates and an 8-minute irradiation by a 798 nm pulse laser reduced the survival rate of cultured Staphylococcus aureus (<em>S. aureus</em>) bacterial cells to 44.5 % ± 3.4 %. To the best of our knowledge, BFO and BFO-PPIX conjugates have not been used previously for advancing the conventional PDT treatment using SHG for deeper and precise treatment in <em>S. aureus.</em></div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104512"},"PeriodicalIF":3.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of retinal curvature with ocular biometry in patients with myopia","authors":"Guo-Ren Xu ,&nbsp;Ming Yan ,&nbsp;Zhen Huang ,&nbsp;Ya Ye ,&nbsp;Yan-Ping Song","doi":"10.1016/j.pdpdt.2025.104505","DOIUrl":"10.1016/j.pdpdt.2025.104505","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the relationship between retinal curvature (RC) and ocular biometry in patients with myopia.</div></div><div><h3>Method</h3><div>The clinical data of 74 patients with myopia (148 eyes) were retrospectively analyzed. Macular 24×20 mm optical coherence tomography (OCT) scans were acquired using an ultra-widefield swept-source optical coherence tomography (UWF SS-OCT) system. The software then identified the Bruch's membrane and integrated it with the axial length (AL) for morphological correction, yielding a fitted three-dimensional retinal model. From this model, an RC map was generated, detailing the Gaussian curvature at each point. The maximum retinal curvature (RCmax) and central macular retinal curvature (RCc) were analyzed.</div></div><div><h3>Results</h3><div>A total of 148 eyes were analyzed. The analysis revealed that RCmax was negatively correlated with AL (<em>r</em>=-0.266, <em>P</em> &lt; 0.05) and positively correlated with mean keratometry (Km) (<em>r</em> = 0.285, <em>P</em> &lt; 0.05). RCc was also positively correlated with Km (<em>r</em> = 0.167, <em>P</em> &lt; 0.05), whereas RCmax and RCc were positively correlated with each other (<em>r</em> = 0.450, <em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>In eyes with large innate eyeballs (characterized by a smaller Km), the RCmax was smaller, and acquired axial elongation (characterized by a larger AL) led to a reduction in RCmax, and vice versa. Eyes with large innate eyeballs also showed a smaller RCc, and vice versa.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104505"},"PeriodicalIF":3.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}