Photodiagnosis and Photodynamic Therapy最新文献

{"title":"SS-OCTA versus ICGA: a comparison of detection efficiency for large choroidal vein patterns in AMD patients","authors":"Nianjia Wang ,&nbsp;Xindi Liu ,&nbsp;Jiayi Wu ,&nbsp;Xintong Xiang ,&nbsp;Yujia Gao ,&nbsp;Liang Yao ,&nbsp;Xin Wang","doi":"10.1016/j.pdpdt.2025.105303","DOIUrl":"10.1016/j.pdpdt.2025.105303","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the efficacy of swept-source optical coherence tomography angiography (SS-OCTA) and indocyanine green angiography (ICGA) in visualizing and classifying large choroidal vein topography, and to evaluate the association between specific venous patterns and pachychoroid spectrum disease (PSD)-associated macular neovascularization (MNV).</div></div><div><h3>Methods</h3><div>This retrospective cross-sectional study included 222 eyes from 160 patients with neovascular age-related macular degeneration (nAMD). All participants underwent both SS-OCTA and ICGA imaging. Choroidal venous patterns were classified into four types based on ICGA venous phase images: watershed, anastomotic, upper thicker, and lower thicker. SS-OCTA images were processed and analyzed using Fiji software. Diagnostic agreement between modalities was assessed using Cohen’s Kappa. Logistic regression was used to evaluate the association between venous patterns and disease subtypes.</div></div><div><h3>Results</h3><div>SS-OCTA and ICGA showed almost perfect agreement in classifying choroidal venous patterns in discernible cases (unweighted Kappa = 0.978). Among 77 eyes where ICGA failed to provide a clear classification, SS-OCTA achieved a definitive diagnosis in 87.0 % (P &lt; 0.001), with the anastomotic type being the most common. Furthermore, the watershed pattern was significantly more prevalent in non-PCV nAMD compared to PCV (29.8 % vs. 12.1 %, p = 0.002), suggesting distinct choroidal venous backgrounds between these subtypes.</div></div><div><h3>Conclusion</h3><div>SS-OCTA provides a reliable, non-invasive alternative to ICGA for visualizing and classifying large choroidal veins, with superior performance in cases obscured by hemorrhage or leakage. The distinct distribution of venous patterns across nAMD subtypes highlights the potential role of choroidal venous architecture in disease phenotyping and pathogenesis.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105303"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on “clinical outcomes of selective laser trabeculoplasty in military pilots with open-angle glaucoma: Implications for intraocular pressure control and aeromedical certification”","authors":"Shashank Dokania,&nbsp;Parth Aphale,&nbsp;Himanshu Shekhar","doi":"10.1016/j.pdpdt.2025.105281","DOIUrl":"10.1016/j.pdpdt.2025.105281","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105281"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145484346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scleral iontophoresis for targeted lutein delivery in intermediate stage dry AMD: Is this a new frontier in age macular degeneration?","authors":"Michele Rinaldi ,&nbsp;Gilda Cennamo ,&nbsp;Gaetano Fioretto ,&nbsp;Maria Laura Passaro ,&nbsp;Fulvia De Falco ,&nbsp;Matteo Bertocchi ,&nbsp;Maddalena Marotta ,&nbsp;Flavia Chiosi ,&nbsp;Francesco Calabro ,&nbsp;Diego Strianese ,&nbsp;Ciro Costagliola","doi":"10.1016/j.pdpdt.2026.105356","DOIUrl":"10.1016/j.pdpdt.2026.105356","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the retinal morphofunctional changes in patients with stage 2 age-related macular degeneration (AMD) following scleral iontophoresis for lutein delivery, and to assess its safety.</div></div><div><h3>Methods</h3><div>In this prospective, non-randomized, single-arm pilot study, 30 stage 2 AMD patients (mean age 71.6 ± 10.88 years) received scleral iontophoresis with a liquid lutein formulation. Comprehensive ophthalmologic assessments—including best-corrected visual acuity (BCVA), macular pigment optical density (MPOD) via one-wavelength reflectometry, and microperimetry (mean sensitivity, mean defect, and fixation stability measured as BCEA)—were performed at baseline and at 6 months. Adverse events were monitored, and ocular surface health was assessed using the Ocular Surface Disease Index (OSDI).</div></div><div><h3>Results</h3><div>At 6 months, MPOD significantly increased from 0.169 ± 0.06 to 0.180 ± 0.075 density units (p = 0.0313). Mean sensitivity improved from 7.26 ± 5.13 dB to 8.18 ± 4.57 dB (p = 0.0179), and mean defect improved from –11.48 ± 4.90 dB to –10.27 ± 3.76 dB (p = 0.0207). Fixation stability, as measured by BCEA at 3 standard deviations, significantly decreased (p = 0.0107). No significant change was observed in BCVA, and OSDI scores remained stable. No adverse events were reported.</div></div><div><h3>Conclusions</h3><div>Scleral iontophoresis of lutein is a safe and promising technique to enhance local MPOD and retinal sensitivity in intermediate AMD patients. Further studies with larger cohorts are warranted to confirm these preliminary findings.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105356"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using a new type of visible light-based emission fluorescence microscope to identify the benign and malignant nature of thyroid tissue during the surgical process: Analysis of diagnostic results","authors":"Yu Miao ,&nbsp;Liu Xiaowei ,&nbsp;Li Muyang ,&nbsp;Gao Jian ,&nbsp;Chen Lu","doi":"10.1016/j.pdpdt.2025.105324","DOIUrl":"10.1016/j.pdpdt.2025.105324","url":null,"abstract":"<div><h3>Objective</h3><div><strong>:</strong> This study evaluated the accuracy and reliability of a new type of visible light-based emission fluorescence microscope [the EndoSCell cell optical scanner (EndoSCell)] in identifying the pathological features of papillary thyroid carcinoma, the spread of lymph nodes in the neck, and the parathyroid glands.</div></div><div><h3>Method</h3><div><strong>:</strong> The thyroid papillary carcinoma tissue samples, lymph node tissue samples, and parathyroid tissue samples were diagnosed using EndoSCell images and frozen sections, and the detection times were recorded. The Hematoxylin and eosin (HE) staining results were used as the gold standard.</div></div><div><h3>Result</h3><div><strong>:</strong> EndoSCell boasts extremely high imaging clarity, enabling it to clearly distinguish the spatial distribution and morphological characteristics of stained cell nuclei and cytoplasm within the observed tissue samples (healthy tissues, lesion areas). The sensitivity, specificity and accuracy of using EndoSCell images to determine the benign or malignant nature of thyroid papilloma, the presence of cervical lymph node metastasis, and the status of parathyroid tissue were (96.43%, 100%, 97.22%), (92.6%, 92.3%, 92.5%), and (91.3%, 91.7%, 91.4%), respectively. The detection times for EndoSCell and frozen sections were 180.77 ± 45.03 s and 1835 ± 538.12 s respectively.</div></div><div><h3>Conclusion</h3><div><strong>:</strong> The diagnostic efficacy of EndoSCell is comparable to that of frozen sections, and the diagnostic results of EndoSCell are highly consistent with the pathological diagnosis of frozen sections. EndoSCell is expected to enable doctors to precisely and accurately remove cancerous tissues in real time while protecting important tissues such as the parathyroid glands and the recurrent laryngeal nerve.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105324"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased choroidal stromal volume and altered choriocapillaris perfusion in neovascular AMD: An SS-OCTA association study","authors":"Xuelin Chen ,&nbsp;Xuenan Zhuang ,&nbsp;Guiqin He ,&nbsp;Miaoling Li ,&nbsp;Xiongze Zhang ,&nbsp;Jiaxin Pu ,&nbsp;Yuying Ji ,&nbsp;Yining Zhang ,&nbsp;Xinlei Hao ,&nbsp;Feng Wen","doi":"10.1016/j.pdpdt.2025.105327","DOIUrl":"10.1016/j.pdpdt.2025.105327","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to characterize quantitative choroidal metrics using swept-source optical coherence tomography angiography (SS-OCTA) across different stages associated with neovascular age-related macular degeneration (nAMD) and to identify structural and vascular associations.</div></div><div><h3>Methods</h3><div>This cross-sectional study utilized SS-OCTA to quantify 6.0 × 6.0 mm² macular choriocapillaris flow density (CCFD), choroidal volume (CV), choroidal stromal volume (CSV), and choroidal vascular volume (CVV), choroidal stromal index (CSI), choroidal vascularity index (CVI) and CSV/CVV ratio. Comparisons were conducted between each pair of three groups: control eyes from healthy participants, fellow eyes and nAMD affected eyes from the same unilateral nAMD patients (fellow eyes representing a potential preclinical stage).</div></div><div><h3>Results</h3><div>The study included 230 healthy control eyes from 116 age- and sex- matched participants, 110 unaffected fellow eyes and 104 nAMD affected eyes from 110 unilateral nAMD patients. Median CCFD was 45.33% (IQR: 4.82%) in controls, 46.50% (IQR: 2.35%) in fellow eyes and 44.41% (IQR: 6.68%) in nAMD eyes. Significant differences were found between controls and fellow eyes (Adjusted <em>P</em> = 0.003) and between fellow eyes and nAMD eyes (Adjusted <em>P</em> &lt; 0.001). Median CSV was significantly higher in both unaffected fellow eyes (5.92 mm³, IQR: 2.67 mm³; Adjusted <em>P</em> = 0.006) and nAMD affected eyes (6.12 mm³, IQR: 2.71 mm³; Adjusted <em>P</em> = 0.012) compared to controls (5.49 mm³, IQR: 2.00 mm³). Other absolute volumes also showed significant intergroup differences: CV differed between control and fellow eyes (Adjusted <em>P</em> = 0.033), while CVV differed significantly only between affected and fellow eyes (Adjusted <em>P</em> = 0.015). In contrast, normalized compositional metrics (CSI, CVI and CSV/CVV ratio) showed no significant intergroup differences (all Adjusted <em>P</em> &gt; 0.05). Multivariate regression analysis in nAMD affected eyes revealed an overall inverse correlation between CSV and CCFD, with this relationship reaching statistical significance the superior nasal, nasal, inferior temporal, inferior and inferior nasal quadrants (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This cross-sectional study demonstrated an association between increased CSV and the presence of nAMD, including in high-risk fellow eyes. The inverse correlation between CSV and CCFD in nAMD eyes suggested a potential interplay between stromal expansion and microvascular compromise. These findings highlighted increased CSV as a candidate biomarker that warranted investigation in future longitudinal studies to determine its prognostic value for nAMD development.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105327"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kaplan-Meier survival analysis of Mohs micrographic surgery with or without photodynamic therapy for locally advanced basal cell carcinoma","authors":"Sunny Chi Lik Au","doi":"10.1016/j.pdpdt.2025.105302","DOIUrl":"10.1016/j.pdpdt.2025.105302","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105302"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axial and choroidal changes as key predictors of myopia control in red-light therapy: Evidence from machine learning models","authors":"Xiaoxue Hu ,&nbsp;Zixun Wang ,&nbsp;Rui Li ,&nbsp;Boxuan Sun ,&nbsp;Dingkang Wang ,&nbsp;Hui Zong ,&nbsp;Xiaoling Zhang ,&nbsp;Ruihua Wei ,&nbsp;Hong Jie","doi":"10.1016/j.pdpdt.2026.105342","DOIUrl":"10.1016/j.pdpdt.2026.105342","url":null,"abstract":"<div><h3>Background</h3><div>Repeated low-level red-light (RLRL) therapy has emerged as a promising non-invasive intervention for myopia control. However, the predictive factors underlying its efficacy remain insufficiently explored.</div></div><div><h3>Methods</h3><div>This multicenter cohort study included 538 pediatric patients who underwent RLRL treatment with a minimum follow-up of one year. Baseline ocular parameters and dynamic changes in axial length (AL) and choroidal thickness (ChT) over three months were collected. Multiple feature selection approaches—LASSO regression, Boruta, recursive elimination, and multivariate regression—were applied. Seven machine learning algorithms were trained, and their performance was evaluated using the area under the curve (AUC), sensitivity, specificity, and F1 score. SHAP and LIME analyses were utilized for interpretability.</div></div><div><h3>Results</h3><div>Logistic regression and gradient boosting models demonstrated the highest discriminative ability. XGBoost achieved optimal performance (AUC: 0.90–0.92; accuracy: 87.7–88.2 %; F1 score: 0.72–0.86). Across one- and two-year prediction models, six stable predictors were identified: age, baseline AL, anterior chamber depth (ACD), RNFL thickness at the temporal inferior quadrant (TI), ChangeAL, and ChangeChT. SHAP analysis revealed that ChangeAL was the dominant short-term predictor, whereas ChangeChT was most influential for long-term outcomes. Older age and greater choroidal thickening were consistently associated with a protective effect against myopia progression.</div></div><div><h3>Conclusions</h3><div>We developed and validated an interpretable machine learning model that accurately predicts short- and long-term outcomes of RLRL therapy in children. ChangeAL and ChangeChT serve as key dynamic biomarkers for treatment monitoring. These findings provide a foundation for personalized clinical decision-making in myopia management.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105342"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145946649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of insulin therapy with diabetic retinopathy in type 2 diabetes: A cross-sectional analysis from the Beichen Eye Study","authors":"Jingyao Liu,&nbsp;Qianhui Yang,&nbsp;Juping Liu,&nbsp;Xiaorong Li","doi":"10.1016/j.pdpdt.2026.105345","DOIUrl":"10.1016/j.pdpdt.2026.105345","url":null,"abstract":"<div><h3>Purpose</h3><div>To describe and investigate the associations between different glucose-lowering management and diabetic retinopathy (DR).</div></div><div><h3>Methods</h3><div>Our study was a cross-sectional analysis. By comparing different glucose-lowering management methods, we aim to explore their impact on the occurrence of diabetic retinopathy (DR) and their influence on its severity. Logistic regression models were used to estimate the odds ratio (OR).</div></div><div><h3>Results</h3><div>Through the Beichen Eye Study (BCES), 844 patients were included in the cross-sectional analysis. The prevalence of DR was 19.30% among patients on oral hypoglycemic agents (OHA), 50.00% on insulin treatment, and 37.12% among those on combined use, giving an overall frequency of 24.65%. No statistically significant differences were observed among different types of oral hypoglycemic agents on the incidence and severity of DR. Logistic regression showed insulin therapy was associated with the prevalence of DR [insulin: OR= 3.57 (95% CI: 1.16 ∼ 11.05), p= 0.027; combination: OR= 2.01 (95% CI: 1.39 ∼ 2.91), p&lt; 0.001].</div></div><div><h3>Conclusion</h3><div>Compared with OHA, either increasing insulin therapy or using insulin alone can be a risk factor for DR, yet it has no impact on DR severity.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105345"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of the combination of trephination abrasion with 5-aminolevulinic acid photodynamic therapy for verruca plana: A retrospective study","authors":"Li-chao Zhang ,&nbsp;Hai-feng Huang ,&nbsp;Xian-fei Guo","doi":"10.1016/j.pdpdt.2025.105314","DOIUrl":"10.1016/j.pdpdt.2025.105314","url":null,"abstract":"<div><h3>Background</h3><div>Studies have shown that photodynamic therapy (PDT) is an effective and non-invasive technique for treating verruca plana. However, due to the limited penetration depth of photosensitizers and light sources, the efficacy of PDT for patients with verruca plana is still limited. Herein, we adopted trephination abrasion combined with 5-aminolevulinic acid (ALA) PDT for verruca plana.</div></div><div><h3>Methods</h3><div>A retrospective study of trephination abrasion combined with ALA-PDT for verruca plana was conducted. After the warts were superficially abraded by a disposable biopsy punch as trephine, ALA-PDT was performed. The effective rate was calculated with the cured and excellent response rates.</div></div><div><h3>Results</h3><div>A total of 50 patients were reported in this study. At the second week, 25 (50.0 %) patients showed complete response and 10 (20.0 %) patients showed excellent response, resulting in a total effectiveness rate of 70.0 %. At the fourth week, 47 (94.0 %) patients showed complete response and one (2.0 %) patient showed excellent response, resulting in a total effectiveness rate of 96.0 %. At the sixth week, 49 (98.0 %) patients showed complete response and one (2.0 %) patient showed excellent response, resulting in a total effectiveness rate of 100.0 %. Two (4.1 %) patients experienced recurrence at the 24th week, resulting in a total effectiveness rate of 96.0 %. At the 6-month follow-up, no hyperpigmentation was observed.</div></div><div><h3>Conclusions</h3><div>A combination of trephination abrasion with ALA-PDT was safe, economical and effective in treatment for verruca plana.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105314"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of 5-aminolevulenic acid fluorescence for diagnostic guidance in intracranial lymphoma surgery: A case series and systematic review of 170 patients","authors":"Dong-Won Shin,&nbsp;Joon-Hyuk Jeong,&nbsp;Gi-Taek Yee","doi":"10.1016/j.pdpdt.2025.105318","DOIUrl":"10.1016/j.pdpdt.2025.105318","url":null,"abstract":"<div><h3>Background</h3><div>Intracranial lymphomas are rare tumors of the central nervous system, predominantly affecting elderly patients. While 5-aminolevulinic acid (5-ALA) fluorescence is well established in glioma surgery, its diagnostic role in intracranial lymphoma remains unclear, particularly regarding the effect of corticosteroid use. This study evaluated the diagnostic performance of 5-ALA-guided biopsy and its relationship with corticosteroid exposure.</div></div><div><h3>Methods</h3><div>We conducted a retrospective case series and a systematic review. Adult patients who underwent stereotactic or open biopsy with 5-ALA guidance for radiologically suspected intracranial lymphoma at Gachon University Gil Medical Center (2022–2025) were analyzed. A comprehensive literature search (MEDLINE, EMBASE, Web of Science, Cochrane Library) through May 2025 identified studies reporting 5-ALA use in intracranial lymphoma biopsy. Diagnostic yield, fluorescence patterns, and corticosteroid effects were assessed.</div></div><div><h3>Results</h3><div>Five patients were included in the institutional series: strong fluorescence was observed in four and vague in one, with an overall positive predictive value of 80 %. Across 18 studies (170 patients), 5-ALA fluorescence was detected in 77.6 %, with 78 % pooled sensitivity and 22 % false-negative rate. Among 12 patients with documented corticosteroid use, discontinuation ≥7 days before biopsy correlated with higher fluorescence positivity, though not consistently with diagnostic success.</div></div><div><h3>Conclusions</h3><div>5-ALA fluorescence serves as a useful adjunct for intracranial lymphoma biopsy, enhancing sampling efficiency and procedural safety. However, fluorescence alone cannot ensure diagnostic adequacy, and frozen section confirmation remains necessary. Corticosteroid use does not uniformly suppress fluorescence but may influence diagnostic reliability.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105318"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}